RFX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)8.67518715
2fusion of sperm to egg plasma membrane (GO:0007342)8.43388590
3sperm motility (GO:0030317)8.30753225
4axonemal dynein complex assembly (GO:0070286)7.58666416
5cilium or flagellum-dependent cell motility (GO:0001539)7.57232247
6sperm-egg recognition (GO:0035036)7.53396820
7acrosome reaction (GO:0007340)7.28334585
8motile cilium assembly (GO:0044458)7.16601494
9binding of sperm to zona pellucida (GO:0007339)7.11231593
10regulation of cilium movement (GO:0003352)7.09916691
11piRNA metabolic process (GO:0034587)6.94308193
12epithelial cilium movement (GO:0003351)6.88312538
13multicellular organism reproduction (GO:0032504)6.77122262
14spermatid development (GO:0007286)6.73040872
15cell-cell recognition (GO:0009988)6.68885752
16cell wall macromolecule metabolic process (GO:0044036)6.45926259
17cell wall macromolecule catabolic process (GO:0016998)6.45926259
18intraciliary transport (GO:0042073)6.34493245
19plasma membrane fusion (GO:0045026)6.29794304
20acrosome assembly (GO:0001675)6.23456344
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.18689026
22synaptonemal complex organization (GO:0070193)5.94762268
23cilium organization (GO:0044782)5.92577520
24cilium movement (GO:0003341)5.86221549
25synaptonemal complex assembly (GO:0007130)5.79295094
26cilium assembly (GO:0042384)5.75924913
27male meiosis (GO:0007140)5.74563721
28left/right axis specification (GO:0070986)5.60581681
29reproduction (GO:0000003)5.58818672
30microtubule depolymerization (GO:0007019)5.26796890
31microtubule bundle formation (GO:0001578)5.06009566
32protein localization to cilium (GO:0061512)4.91965746
33single fertilization (GO:0007338)4.67168667
34cilium morphogenesis (GO:0060271)4.66824234
35spermatogenesis (GO:0007283)4.66576259
36male gamete generation (GO:0048232)4.65322306
37negative regulation of inclusion body assembly (GO:0090084)4.63290124
38fertilization (GO:0009566)4.49534061
39male meiosis I (GO:0007141)4.49421808
40cellular component assembly involved in morphogenesis (GO:0010927)4.44394988
41response to xenobiotic stimulus (GO:0009410)4.38457024
42chromosome condensation (GO:0030261)4.34748607
43gamete generation (GO:0007276)4.32261958
44centriole assembly (GO:0098534)4.28182039
45meiotic nuclear division (GO:0007126)4.24729783
46DNA methylation involved in gamete generation (GO:0043046)4.21871755
47chromosome organization involved in meiosis (GO:0070192)4.18356420
48regulation of germinal center formation (GO:0002634)4.18181366
49DNA packaging (GO:0006323)4.12481650
50regulation of inclusion body assembly (GO:0090083)4.11963131
51regulation of microtubule-based movement (GO:0060632)4.11693083
52meiotic cell cycle (GO:0051321)4.09154619
53germ cell development (GO:0007281)4.09074643
54primary alcohol catabolic process (GO:0034310)3.99725368
55cell projection assembly (GO:0030031)3.93522193
56meiosis I (GO:0007127)3.92503675
57cellular process involved in reproduction in multicellular organism (GO:0022412)3.86583727
58organic cation transport (GO:0015695)3.81657357
59negative regulation of immunoglobulin mediated immune response (GO:0002890)3.80761743
60negative regulation of B cell mediated immunity (GO:0002713)3.80761743
61microtubule severing (GO:0051013)3.79802642
62interferon-gamma secretion (GO:0072643)3.79628233
63sperm capacitation (GO:0048240)3.78324658
64protein localization to chromosome, centromeric region (GO:0071459)3.77460376
65ventricular system development (GO:0021591)3.77420747
66DNA replication-dependent nucleosome assembly (GO:0006335)3.76985111
67DNA replication-dependent nucleosome organization (GO:0034723)3.76985111
68nonmotile primary cilium assembly (GO:0035058)3.74428817
69nuclear pore complex assembly (GO:0051292)3.70612987
70gene silencing by RNA (GO:0031047)3.68364442
71tolerance induction (GO:0002507)3.67272147
72centriole replication (GO:0007099)3.66030823
73positive regulation of oligodendrocyte differentiation (GO:0048714)3.64684204
74regulation of spindle checkpoint (GO:0090231)3.59730021
75mitotic sister chromatid cohesion (GO:0007064)3.58847553
76monoubiquitinated protein deubiquitination (GO:0035520)3.56672749
77one-carbon compound transport (GO:0019755)3.56159257
78regulation of histone H3-K9 methylation (GO:0051570)3.51013253
79photoreceptor cell maintenance (GO:0045494)3.48099161
80microtubule-based movement (GO:0007018)3.40334881
81smoothened signaling pathway (GO:0007224)3.38997377
82multicellular organismal reproductive process (GO:0048609)3.37666051
83seminiferous tubule development (GO:0072520)3.37385853
84mitotic sister chromatid segregation (GO:0000070)3.37237448
85nuclear pore organization (GO:0006999)3.36730155
86RNA localization (GO:0006403)3.35750953
87heterochromatin organization (GO:0070828)3.28945826
88lung epithelium development (GO:0060428)3.27320571
89meiotic cell cycle process (GO:1903046)3.26861669
90phagocytosis, recognition (GO:0006910)3.24151228
91chaperone-mediated protein complex assembly (GO:0051131)3.22648636
92microtubule polymerization or depolymerization (GO:0031109)3.18621081
93ethanol metabolic process (GO:0006067)3.16868887
94pyrimidine-containing compound transmembrane transport (GO:0072531)3.15970869
95histone H4-K12 acetylation (GO:0043983)3.13087613
96negative regulation of T cell differentiation in thymus (GO:0033085)3.12262721
97protein polyglutamylation (GO:0018095)3.11610999
98diterpenoid biosynthetic process (GO:0016102)3.11424238
99vitamin transmembrane transport (GO:0035461)3.08113108
100neural tube formation (GO:0001841)3.07548809
101determination of left/right symmetry (GO:0007368)3.06361383
102spinal cord motor neuron differentiation (GO:0021522)3.05485819
103left/right pattern formation (GO:0060972)3.03820822
104glycerol ether metabolic process (GO:0006662)3.03520810
105sister chromatid segregation (GO:0000819)3.03456369
106intra-S DNA damage checkpoint (GO:0031573)3.01766404
107histone H4-K8 acetylation (GO:0043982)2.98982598
108histone H4-K5 acetylation (GO:0043981)2.98982598
109nucleus organization (GO:0006997)2.98848423
110gene silencing (GO:0016458)2.98323876
111cell recognition (GO:0008037)2.97806383
112regulation of interleukin-6 biosynthetic process (GO:0045408)2.97544085
113genitalia morphogenesis (GO:0035112)2.96960721
114single strand break repair (GO:0000012)2.94458164
115DNA deamination (GO:0045006)2.94313745
116hydrogen peroxide biosynthetic process (GO:0050665)2.93767738
117determination of bilateral symmetry (GO:0009855)2.93469157
118protein complex localization (GO:0031503)2.91320260
119mitotic nuclear envelope disassembly (GO:0007077)2.91048837
120negative regulation of humoral immune response (GO:0002921)2.90910027
121regulation of meiosis I (GO:0060631)2.90398113
122DNA damage response, signal transduction resulting in transcription (GO:0042772)2.90384109
123protein-DNA complex disassembly (GO:0032986)2.89822688
124nucleosome disassembly (GO:0006337)2.89822688
125limb development (GO:0060173)2.89565301
126appendage development (GO:0048736)2.89565301
127regulation of response to osmotic stress (GO:0047484)2.87068668
128specification of symmetry (GO:0009799)2.83271906
129histone exchange (GO:0043486)2.83063709
130DNA double-strand break processing (GO:0000729)2.82772330
131pore complex assembly (GO:0046931)2.82414767
132replication fork processing (GO:0031297)2.80598065
133L-fucose catabolic process (GO:0042355)2.78969343
134fucose catabolic process (GO:0019317)2.78969343
135L-fucose metabolic process (GO:0042354)2.78969343
136DNA conformation change (GO:0071103)2.78447463
137maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.76981026
138chromosome organization (GO:0051276)2.76029772
139ether metabolic process (GO:0018904)2.75097529
140lateral ventricle development (GO:0021670)2.74861027
141regulation of centriole replication (GO:0046599)2.74393645
142multicellular organismal development (GO:0007275)2.74159589
143chromatin assembly (GO:0031497)2.73987076
144response to pheromone (GO:0019236)2.72246953
145membrane disassembly (GO:0030397)2.72180240
146nuclear envelope disassembly (GO:0051081)2.72180240
147reactive oxygen species biosynthetic process (GO:1903409)2.71825809
148poly(A)+ mRNA export from nucleus (GO:0016973)2.71477506
149retinoic acid metabolic process (GO:0042573)2.71342485
150dopamine transport (GO:0015872)2.66042557
151retinal cone cell development (GO:0046549)2.65946352
152positive regulation of tolerance induction (GO:0002645)2.64609730
153regulation of collateral sprouting (GO:0048670)2.64046769
154nucleoside diphosphate phosphorylation (GO:0006165)2.63029797
155neutrophil activation involved in immune response (GO:0002283)2.62554971
156cytoplasmic microtubule organization (GO:0031122)2.53549683
157detection of light stimulus involved in sensory perception (GO:0050962)2.50886879
158detection of light stimulus involved in visual perception (GO:0050908)2.50886879
159organelle assembly (GO:0070925)2.50178780
160terpenoid biosynthetic process (GO:0016114)2.42888084
161retinal rod cell development (GO:0046548)2.41798066
162glutathione derivative biosynthetic process (GO:1901687)2.38395707
163glutathione derivative metabolic process (GO:1901685)2.38395707
164aldehyde catabolic process (GO:0046185)2.38258718
165regulation of interleukin-5 production (GO:0032674)2.38054313
166neuron fate determination (GO:0048664)2.34982340
167rRNA catabolic process (GO:0016075)2.34028958
168exogenous drug catabolic process (GO:0042738)2.33647375
169superoxide anion generation (GO:0042554)2.33401059
170olfactory bulb development (GO:0021772)2.32198257
171reciprocal DNA recombination (GO:0035825)2.31438492
172reciprocal meiotic recombination (GO:0007131)2.31438492
173regulation of oligodendrocyte differentiation (GO:0048713)2.30409700
174cornea development in camera-type eye (GO:0061303)2.28550590
175phosphatidylethanolamine biosynthetic process (GO:0006646)2.24912320
176regulation of acrosome reaction (GO:0060046)2.22838859
177thyroid hormone metabolic process (GO:0042403)2.22131928
178sialylation (GO:0097503)2.22094617
179cell differentiation in spinal cord (GO:0021515)2.21338604
180regulation of tolerance induction (GO:0002643)2.21052551
181phosphatidylethanolamine metabolic process (GO:0046337)2.20637615
182phenol-containing compound catabolic process (GO:0019336)2.20381640
183negative regulation of adaptive immune response (GO:0002820)2.18641302
184positive regulation of digestive system process (GO:0060456)2.18156028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.97097030
2E2F7_22180533_ChIP-Seq_HELA_Human5.23564629
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.02351989
4VDR_22108803_ChIP-Seq_LS180_Human3.28595480
5ZNF274_21170338_ChIP-Seq_K562_Hela3.04260073
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.75506743
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65831249
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45224430
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33667989
10* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.28737054
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26200395
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.21260165
13* DROSHA_22980978_ChIP-Seq_HELA_Human2.01390024
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99993237
15BCAT_22108803_ChIP-Seq_LS180_Human1.99270744
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.95979883
17STAT3_1855785_ChIP-Seq_MESCs_Mouse1.95738494
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94007814
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.87593914
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84931930
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84222258
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84222258
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84222258
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82609377
25GATA1_26923725_Chip-Seq_HPCs_Mouse1.80800157
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80739335
27GBX2_23144817_ChIP-Seq_PC3_Human1.80354150
28* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79808225
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79722801
30NR3C1_21868756_ChIP-Seq_MCF10A_Human1.76946333
31IGF1R_20145208_ChIP-Seq_DFB_Human1.74952086
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.74195747
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73651144
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72979058
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72423595
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67728918
37EWS_26573619_Chip-Seq_HEK293_Human1.66665276
38ER_23166858_ChIP-Seq_MCF-7_Human1.62774970
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61437530
40TAF15_26573619_Chip-Seq_HEK293_Human1.58576006
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.58044480
42SMAD4_21799915_ChIP-Seq_A2780_Human1.57793920
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55598562
44P300_19829295_ChIP-Seq_ESCs_Human1.55309169
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54154859
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.52474433
47AHR_22903824_ChIP-Seq_MCF-7_Human1.51475520
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50314682
49* STAT3_23295773_ChIP-Seq_U87_Human1.50255733
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49656041
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48739898
52* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48629117
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47974883
54TCF4_22108803_ChIP-Seq_LS180_Human1.45394104
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45135684
56FUS_26573619_Chip-Seq_HEK293_Human1.44262125
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44152165
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43244585
59CBP_20019798_ChIP-Seq_JUKART_Human1.42126999
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42126999
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40710021
62EZH2_22144423_ChIP-Seq_EOC_Human1.40615284
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39933618
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39933618
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.39561966
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38491975
67* TCF4_23295773_ChIP-Seq_U87_Human1.36852627
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35465287
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.35465287
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.34924175
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34840389
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.34710827
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34032143
74SMRT_27268052_Chip-Seq_Bcells_Human1.33091481
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.32676908
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32675520
77AR_20517297_ChIP-Seq_VCAP_Human1.31983497
78* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30603361
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29108930
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27973878
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27534026
82AR_25329375_ChIP-Seq_VCAP_Human1.27449956
83TP53_22573176_ChIP-Seq_HFKS_Human1.27057875
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26890570
85RUNX2_22187159_ChIP-Seq_PCA_Human1.25115076
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.24114019
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.23904119
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22390408
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.21956652
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.21024535
91NANOG_19829295_ChIP-Seq_ESCs_Human1.20592906
92SOX2_19829295_ChIP-Seq_ESCs_Human1.20592906
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18525101
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18265528
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17898382
96RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17151407
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16993943
98TET1_21451524_ChIP-Seq_MESCs_Mouse1.16974668
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16400210
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15715197
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15516280
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15126674
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14715474
104SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14442690
105FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14367609
106MYC_19829295_ChIP-Seq_ESCs_Human1.13442624
107PHF8_20622854_ChIP-Seq_HELA_Human1.13290954
108YY1_21170310_ChIP-Seq_MESCs_Mouse1.13248176
109POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12431854
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11829877
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11389859
112RARA_24833708_ChIP-Seq_LIVER_Mouse1.11265612
113* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10787661
114ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10212142
115SOX2_22085726_ChIP-Seq_NPCs_Mouse1.10163632
116IRF1_19129219_ChIP-ChIP_H3396_Human1.10037300
117MYC_22102868_ChIP-Seq_BL_Human1.10032379
118SMAD4_21741376_ChIP-Seq_EPCs_Human1.09969395
119SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09607914
120TP53_16413492_ChIP-PET_HCT116_Human1.09212656
121NCOR_22424771_ChIP-Seq_293T_Human1.09086703
122VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08903261
123CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08669844
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08639764
125ERA_21632823_ChIP-Seq_H3396_Human1.08432726
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08285849
127ETV1_20927104_ChIP-Seq_GIST48_Human1.07649920
128AR_21909140_ChIP-Seq_LNCAP_Human1.07171646
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06453372
130KAP1_27257070_Chip-Seq_ESCs_Mouse1.06232668
131TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05232568
132TCF7_22412390_ChIP-Seq_EML_Mouse1.05047312
133P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04793677
134TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.02473783
135PRDM14_20953172_ChIP-Seq_ESCs_Human1.02371537
136CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01849242
137KDM5A_27292631_Chip-Seq_BREAST_Human1.01605564
138* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.01568989
139TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01250952
140PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01231147
141PHF8_20622853_ChIP-Seq_HELA_Human1.00926252
142* GATA3_21867929_ChIP-Seq_CD8_Mouse1.00891483
143STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00693772
144JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00039121
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99799956
146SPI1_26923725_Chip-Seq_HPCs_Mouse0.99715513
147XRN2_22483619_ChIP-Seq_HELA_Human0.99428037
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98948046
149P68_20966046_ChIP-Seq_HELA_Human0.98580709
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98558057
151* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98546994
152PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98022738
153TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97786688
154* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97769444
155NFYA_21822215_ChIP-Seq_K562_Human0.97616961
156BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97485156
157GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97275714
158HOXB7_26014856_ChIP-Seq_BT474_Human0.97094352
159ZNF263_19887448_ChIP-Seq_K562_Human0.96392534
160MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96279119
161BCOR_27268052_Chip-Seq_Bcells_Human0.95905711
162ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95708113
163POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95637699
164TBL1_22424771_ChIP-Seq_293T_Human0.95307562
165PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.95270398
166SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95252995
167AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95212516
168REST_21632747_ChIP-Seq_MESCs_Mouse0.94556422
169CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94364235
170TP63_19390658_ChIP-ChIP_HaCaT_Human0.94355912
171GATA3_26560356_Chip-Seq_TH2_Human0.93957032
172NFE2_27457419_Chip-Seq_LIVER_Mouse0.93695553
173SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93244289
174STAT1_20625510_ChIP-Seq_HELA_Human0.92645239
175SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.92517963
176NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91945829
177ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91483409
178NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90776669
179* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90503889
180HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90013593
181WDR5_24793694_ChIP-Seq_LNCAP_Human0.89547937
182E2F1_20622854_ChIP-Seq_HELA_Human0.89179588
183CTCF_20526341_ChIP-Seq_ESCs_Human0.87981915
184POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87774471
185RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86975542
186BCL6_27268052_Chip-Seq_Bcells_Human0.85525258
187PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85246726
188* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85132201
189PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84579692
190RARB_24833708_ChIP-Seq_LIVER_Mouse0.83979589
191ETS1_20019798_ChIP-Seq_JURKAT_Human0.83552183
192GABP_19822575_ChIP-Seq_HepG2_Human0.83093715
193ETS1_21867929_ChIP-Seq_TH2_Mouse0.82632728
194ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82310365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.92360160
2MP0001929_abnormal_gametogenesis4.11322218
3MP0008875_abnormal_xenobiotic_pharmacok4.09278976
4MP0003698_abnormal_male_reproductive4.08311617
5MP0002653_abnormal_ependyma_morphology3.71142945
6MP0008877_abnormal_DNA_methylation3.69199843
7MP0008057_abnormal_DNA_replication3.16551574
8MP0010094_abnormal_chromosome_stability3.12019173
9MP0003646_muscle_fatigue3.04476698
10MP0003111_abnormal_nucleus_morphology2.97941155
11MP0002210_abnormal_sex_determination2.94584590
12MP0002277_abnormal_respiratory_mucosa2.82158948
13MP0008789_abnormal_olfactory_epithelium2.80244508
14MP0001984_abnormal_olfaction2.65080513
15MP0001145_abnormal_male_reproductive2.60477145
16MP0003693_abnormal_embryo_hatching2.55601544
17MP0004957_abnormal_blastocyst_morpholog2.48299948
18MP0002161_abnormal_fertility/fecundity2.40798563
19MP0003195_calcinosis2.35678783
20MP0003077_abnormal_cell_cycle2.34991352
21MP0004043_abnormal_pH_regulation2.29687034
22MP0000653_abnormal_sex_gland2.24141249
23MP0000383_abnormal_hair_follicle2.20043274
24MP0005670_abnormal_white_adipose2.12347539
25MP0008058_abnormal_DNA_repair2.10028832
26MP0005646_abnormal_pituitary_gland1.98668483
27MP0009278_abnormal_bone_marrow1.97470101
28MP0002928_abnormal_bile_duct1.96619471
29MP0005248_abnormal_Harderian_gland1.80224352
30MP0005551_abnormal_eye_electrophysiolog1.79951223
31MP0009780_abnormal_chondrocyte_physiolo1.78529382
32MP0005394_taste/olfaction_phenotype1.76128708
33MP0005499_abnormal_olfactory_system1.76128708
34MP0010678_abnormal_skin_adnexa1.75934356
35MP0003724_increased_susceptibility_to1.73798381
36MP0001835_abnormal_antigen_presentation1.69956183
37MP0005397_hematopoietic_system_phenotyp1.68271747
38MP0001545_abnormal_hematopoietic_system1.68271747
39MP0005377_hearing/vestibular/ear_phenot1.67520341
40MP0003878_abnormal_ear_physiology1.67520341
41MP0004233_abnormal_muscle_weight1.62483219
42MP0002102_abnormal_ear_morphology1.60741483
43MP0003786_premature_aging1.56565591
44MP0001485_abnormal_pinna_reflex1.55836140
45MP0008995_early_reproductive_senescence1.52908304
46MP0002638_abnormal_pupillary_reflex1.52229101
47MP0001730_embryonic_growth_arrest1.43077253
48MP0003136_yellow_coat_color1.40783057
49MP0002168_other_aberrant_phenotype1.39677242
50MP0002084_abnormal_developmental_patter1.38208175
51MP0001293_anophthalmia1.38054747
52MP0008007_abnormal_cellular_replicative1.34837245
53MP0001968_abnormal_touch/_nociception1.32461613
54MP0002160_abnormal_reproductive_system1.30516630
55MP0002735_abnormal_chemical_nociception1.30072555
56MP0001986_abnormal_taste_sensitivity1.29974026
57MP0003806_abnormal_nucleotide_metabolis1.29051833
58MP0000350_abnormal_cell_proliferation1.28206601
59MP0001486_abnormal_startle_reflex1.27183475
60MP0000465_gastrointestinal_hemorrhage1.26260552
61MP0001672_abnormal_embryogenesis/_devel1.24738937
62MP0005380_embryogenesis_phenotype1.24738937
63MP0010352_gastrointestinal_tract_polyps1.23986403
64MP0006292_abnormal_olfactory_placode1.23815869
65MP0005084_abnormal_gallbladder_morpholo1.22967811
66MP0002085_abnormal_embryonic_tissue1.22841531
67MP0004133_heterotaxia1.21761884
68MP0000631_abnormal_neuroendocrine_gland1.21718926
69MP0006276_abnormal_autonomic_nervous1.20828155
70MP0001529_abnormal_vocalization1.20183538
71MP0008932_abnormal_embryonic_tissue1.17710537
72MP0005076_abnormal_cell_differentiation1.16676194
73MP0003787_abnormal_imprinting1.16524714
74MP0000566_synostosis1.15323545
75MP0000569_abnormal_digit_pigmentation1.13531319
76MP0001697_abnormal_embryo_size1.13421430
77MP0000026_abnormal_inner_ear1.12366168
78MP0005174_abnormal_tail_pigmentation1.10196533
79MP0002086_abnormal_extraembryonic_tissu1.09745403
80MP0003283_abnormal_digestive_organ1.08727022
81MP0003656_abnormal_erythrocyte_physiolo1.06404087
82MP0004885_abnormal_endolymph1.06343583
83MP0003880_abnormal_central_pattern1.04679827
84MP0008872_abnormal_physiological_respon1.03728850
85MP0000313_abnormal_cell_death1.03485701
86MP0002080_prenatal_lethality1.02759581
87MP0004264_abnormal_extraembryonic_tissu1.02481003
88MP0001970_abnormal_pain_threshold1.01511094
89MP0010307_abnormal_tumor_latency1.01358458
90MP0005645_abnormal_hypothalamus_physiol1.00449075
91MP0003984_embryonic_growth_retardation1.00240940
92MP0001501_abnormal_sleep_pattern0.98899742
93MP0001765_abnormal_ion_homeostasis0.98225746
94MP0005083_abnormal_biliary_tract0.98161164
95MP0001849_ear_inflammation0.97993596
96MP0009764_decreased_sensitivity_to0.97916341
97MP0004197_abnormal_fetal_growth/weight/0.97865204
98MP0002088_abnormal_embryonic_growth/wei0.97381061
99MP0005195_abnormal_posterior_eye0.93983338
100MP0002736_abnormal_nociception_after0.92137236
101MP0002909_abnormal_adrenal_gland0.91975665
102MP0002282_abnormal_trachea_morphology0.90772811
103MP0002557_abnormal_social/conspecific_i0.90723041
104MP0003890_abnormal_embryonic-extraembry0.89883429
105MP0001324_abnormal_eye_pigmentation0.89046371
106MP0006054_spinal_hemorrhage0.87251456
107MP0005389_reproductive_system_phenotype0.86290255
108MP0002269_muscular_atrophy0.86233712
109MP0005501_abnormal_skin_physiology0.86174874
110MP0009046_muscle_twitch0.85966397
111MP0002877_abnormal_melanocyte_morpholog0.85812269
112MP0005220_abnormal_exocrine_pancreas0.85784442
113MP0005395_other_phenotype0.85663472
114MP0009745_abnormal_behavioral_response0.85567529
115MP0000490_abnormal_crypts_of0.85446798
116MP0005167_abnormal_blood-brain_barrier0.85164494
117MP0002233_abnormal_nose_morphology0.84035800
118MP0003252_abnormal_bile_duct0.83663193
119MP0003705_abnormal_hypodermis_morpholog0.83637020
120MP0000358_abnormal_cell_content/0.82896785
121MP0003119_abnormal_digestive_system0.81726692
122MP0002019_abnormal_tumor_incidence0.81699527
123MP0003115_abnormal_respiratory_system0.81478313
124MP0001502_abnormal_circadian_rhythm0.81227510
125MP0004019_abnormal_vitamin_homeostasis0.80763966
126MP0005310_abnormal_salivary_gland0.80049392
127MP0003699_abnormal_female_reproductive0.78563626
128MP0002138_abnormal_hepatobiliary_system0.78157388
129MP0002796_impaired_skin_barrier0.77904577
130MP0004142_abnormal_muscle_tone0.77854613
131MP0003718_maternal_effect0.77308714
132MP0002405_respiratory_system_inflammati0.77307000
133MP0001963_abnormal_hearing_physiology0.76151181
134MP0004808_abnormal_hematopoietic_stem0.75763353
135MP0005387_immune_system_phenotype0.74840045
136MP0001790_abnormal_immune_system0.74840045
137MP0005666_abnormal_adipose_tissue0.74152758
138MP0002572_abnormal_emotion/affect_behav0.74007860
139MP0008004_abnormal_stomach_pH0.72308565
140MP0003938_abnormal_ear_development0.71763728
141MP0005266_abnormal_metabolism0.71423744
142MP0005636_abnormal_mineral_homeostasis0.70539394
143MP0002876_abnormal_thyroid_physiology0.70405139
144MP0001944_abnormal_pancreas_morphology0.70189365
145MP0001119_abnormal_female_reproductive0.70026954
146MP0005075_abnormal_melanosome_morpholog0.69311082
147MP0002396_abnormal_hematopoietic_system0.68122048
148MP0002092_abnormal_eye_morphology0.66600435
149MP0010030_abnormal_orbit_morphology0.65663367
150MP0002132_abnormal_respiratory_system0.64460491
151MP0003183_abnormal_peptide_metabolism0.64104217
152MP0000427_abnormal_hair_cycle0.63868879
153MP0002419_abnormal_innate_immunity0.62995456
154MP0002970_abnormal_white_adipose0.62972528
155MP0008961_abnormal_basal_metabolism0.62730945
156MP0002693_abnormal_pancreas_physiology0.61150440
157MP0005391_vision/eye_phenotype0.60911570
158MP0005623_abnormal_meninges_morphology0.59498684
159MP0008770_decreased_survivor_rate0.57209489
160MP0002697_abnormal_eye_size0.56922898
161MP0006072_abnormal_retinal_apoptosis0.56385186
162MP0005647_abnormal_sex_gland0.54409011
163MP0002234_abnormal_pharynx_morphology0.52530252
164MP0000467_abnormal_esophagus_morphology0.51782168
165MP0000432_abnormal_head_morphology0.48817012
166MP0002009_preneoplasia0.47854916
167MP0003011_delayed_dark_adaptation0.47031611
168MP0009703_decreased_birth_body0.45089120
169MP0003861_abnormal_nervous_system0.44612451
170MP0001915_intracranial_hemorrhage0.42945875
171MP0005384_cellular_phenotype0.42213524
172MP0003936_abnormal_reproductive_system0.42101864
173MP0003186_abnormal_redox_activity0.41360802
174MP0005253_abnormal_eye_physiology0.40360910
175MP0009115_abnormal_fat_cell0.39781113
176MP0000470_abnormal_stomach_morphology0.39432123

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.37421956
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.37421956
3Abnormal respiratory epithelium morphology (HP:0012253)7.14063803
4Abnormal respiratory motile cilium morphology (HP:0005938)7.14063803
5Abnormal respiratory motile cilium physiology (HP:0012261)6.98960018
6Rhinitis (HP:0012384)5.97249250
7Chronic bronchitis (HP:0004469)5.93617556
8Infertility (HP:0000789)5.64616211
9Nasal polyposis (HP:0100582)5.60099148
10Abnormal ciliary motility (HP:0012262)5.12206512
11Abnormality of the nasal mucosa (HP:0000433)4.64379566
12True hermaphroditism (HP:0010459)4.58084535
13Chronic sinusitis (HP:0011109)4.56245981
14Pancreatic fibrosis (HP:0100732)4.55607511
15Male infertility (HP:0003251)4.41237723
16Pancreatic cysts (HP:0001737)4.16224831
17Chronic otitis media (HP:0000389)4.09018814
18Impulsivity (HP:0100710)3.94675419
19Bronchiectasis (HP:0002110)3.72625036
20Bronchitis (HP:0012387)3.67950962
21Nephronophthisis (HP:0000090)3.58239810
22Cystic liver disease (HP:0006706)3.51729162
23Occipital encephalocele (HP:0002085)3.45478640
24Medial flaring of the eyebrow (HP:0010747)3.22296908
25Chronic hepatic failure (HP:0100626)3.07561452
26Abnormal spermatogenesis (HP:0008669)3.03933688
27Congenital primary aphakia (HP:0007707)2.76546227
28Gait imbalance (HP:0002141)2.73306221
29Recurrent otitis media (HP:0000403)2.72406062
30Anencephaly (HP:0002323)2.59560722
31Abnormality of the renal medulla (HP:0100957)2.59078990
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.58755702
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.55662034
34Abnormality of the lower motor neuron (HP:0002366)2.53838573
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.53051949
36Selective tooth agenesis (HP:0001592)2.51311693
37Nephrogenic diabetes insipidus (HP:0009806)2.49098168
38Heterotopia (HP:0002282)2.48364815
39Decreased central vision (HP:0007663)2.46621020
40Supernumerary spleens (HP:0009799)2.46122757
41Abnormality of the ileum (HP:0001549)2.40638001
42Neoplasm of the oral cavity (HP:0100649)2.37929310
43Abnormal rod and cone electroretinograms (HP:0008323)2.37610565
44Short humerus (HP:0005792)2.31676487
45Atelectasis (HP:0100750)2.30043987
46Abnormality of midbrain morphology (HP:0002418)2.28292607
47Molar tooth sign on MRI (HP:0002419)2.28292607
48Male pseudohermaphroditism (HP:0000037)2.26537933
49Tubular atrophy (HP:0000092)2.26291108
50Postaxial hand polydactyly (HP:0001162)2.24164413
51Sclerocornea (HP:0000647)2.22695722
52Aplasia/hypoplasia of the humerus (HP:0006507)2.22213084
53Meckel diverticulum (HP:0002245)2.21799396
54Decreased circulating renin level (HP:0003351)2.21788859
55Ectopic kidney (HP:0000086)2.17994044
56Recurrent bronchitis (HP:0002837)2.17506566
57Absent thumb (HP:0009777)2.16040721
58Hyperactive renin-angiotensin system (HP:0000841)2.15344704
59Degeneration of anterior horn cells (HP:0002398)2.12515118
60Abnormality of the anterior horn cell (HP:0006802)2.12515118
61Abnormality of the preputium (HP:0100587)2.07095717
62Cleft eyelid (HP:0000625)2.05262981
63Recurrent sinusitis (HP:0011108)2.03982222
64Abnormality of the renal cortex (HP:0011035)2.02429641
65Rib fusion (HP:0000902)2.01477149
66Duodenal stenosis (HP:0100867)2.00232088
67Small intestinal stenosis (HP:0012848)2.00232088
68Oculomotor apraxia (HP:0000657)2.00168984
69Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.4304644
70Furrowed tongue (HP:0000221)1.97988932
71Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97856963
72Genital tract atresia (HP:0001827)1.97003838
73Sloping forehead (HP:0000340)1.96430616
74Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95762595
75Azoospermia (HP:0000027)1.94662408
76Vaginal atresia (HP:0000148)1.93314065
77Abnormality of chromosome stability (HP:0003220)1.92186964
78Gonadotropin excess (HP:0000837)1.91873421
79Poor coordination (HP:0002370)1.90570526
80Preaxial hand polydactyly (HP:0001177)1.89734918
81Postaxial foot polydactyly (HP:0001830)1.89663901
82Clubbing of toes (HP:0100760)1.89404415
83Abnormal drinking behavior (HP:0030082)1.88665569
84Polydipsia (HP:0001959)1.88665569
85Nephropathy (HP:0000112)1.86893832
86Pili torti (HP:0003777)1.84608699
87Squamous cell carcinoma (HP:0002860)1.81095642
88Ependymoma (HP:0002888)1.80010477
89Abolished electroretinogram (ERG) (HP:0000550)1.79591385
90Bony spicule pigmentary retinopathy (HP:0007737)1.79329085
91Chromsome breakage (HP:0040012)1.77988340
92Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77580206
93Facial cleft (HP:0002006)1.75434139
94Congenital stationary night blindness (HP:0007642)1.74966500
95Myelodysplasia (HP:0002863)1.74426030
96Abnormal number of erythroid precursors (HP:0012131)1.74158450
97Retinitis pigmentosa (HP:0000510)1.71932913
98Congenital hepatic fibrosis (HP:0002612)1.71847109
99Median cleft lip (HP:0000161)1.71277329
100Choroideremia (HP:0001139)1.70737802
101Constricted visual fields (HP:0001133)1.69975250
102Abnormality of the heme biosynthetic pathway (HP:0010472)1.69525256
103Abnormality of cells of the erythroid lineage (HP:0012130)1.68519246
104Spastic tetraparesis (HP:0001285)1.67625316
105Short ribs (HP:0000773)1.67002437
106Neoplasm of the tracheobronchial system (HP:0100552)1.65635470
107Tubulointerstitial nephritis (HP:0001970)1.64078331
108Abnormality of the duodenum (HP:0002246)1.61676358
109Aplasia/Hypoplasia of the spleen (HP:0010451)1.61526976
110Nephroblastoma (Wilms tumor) (HP:0002667)1.61152447
111Abnormality of the carotid arteries (HP:0005344)1.60396289
112Premature ovarian failure (HP:0008209)1.58384472
113Alveolar cell carcinoma (HP:0006519)1.56690935
114Deformed sella turcica (HP:0002681)1.53768247
115Asplenia (HP:0001746)1.53161848
116Breast hypoplasia (HP:0003187)1.51412254
117Birth length less than 3rd percentile (HP:0003561)1.51183802
118Amyotrophic lateral sclerosis (HP:0007354)1.51154663
119Narrow forehead (HP:0000341)1.51060875
120Carpal bone hypoplasia (HP:0001498)1.50696351
121Oral leukoplakia (HP:0002745)1.50630273
122Easy fatigability (HP:0003388)1.50287528
123Abnormality of abdominal situs (HP:0011620)1.50017883
124Abdominal situs inversus (HP:0003363)1.50017883
125Absent speech (HP:0001344)1.49827570
126Prominent nasal bridge (HP:0000426)1.48882296
127Onycholysis (HP:0001806)1.48607140
128Aplasia/Hypoplasia of the lens (HP:0008063)1.48356373
129Truncal obesity (HP:0001956)1.48280722
130Stage 5 chronic kidney disease (HP:0003774)1.48233915
131Hypoplasia of the radius (HP:0002984)1.47976836
132Bone marrow hypocellularity (HP:0005528)1.46557661
133Abnormality of macular pigmentation (HP:0008002)1.46455585
134Attenuation of retinal blood vessels (HP:0007843)1.45920503
135Aganglionic megacolon (HP:0002251)1.44037589
136Hypotelorism (HP:0000601)1.43761843
137Reticulocytosis (HP:0001923)1.43458672
138Medulloblastoma (HP:0002885)1.43369103
139Hyperkalemia (HP:0002153)1.42553886
140Hypothermia (HP:0002045)1.41992118
141Absent radius (HP:0003974)1.41961526
142Bile duct proliferation (HP:0001408)1.41625670
143Abnormal biliary tract physiology (HP:0012439)1.41625670
144Facial hemangioma (HP:0000329)1.41546883
145Embryonal renal neoplasm (HP:0011794)1.40626280
146Abnormality of renin-angiotensin system (HP:0000847)1.39320505
147Impaired proprioception (HP:0010831)1.39256674
148Stomatitis (HP:0010280)1.38512673
149Broad foot (HP:0001769)1.38198750
150Renal salt wasting (HP:0000127)1.37862100
151Bell-shaped thorax (HP:0001591)1.37451436
152Elevated erythrocyte sedimentation rate (HP:0003565)1.37124793
153Disproportionate short-trunk short stature (HP:0003521)1.36578700
154Multicystic kidney dysplasia (HP:0000003)1.36200755
155Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.36155763
156Absent epiphyses (HP:0010577)1.36155763
157Tubulointerstitial abnormality (HP:0001969)1.36039725
158EMG: neuropathic changes (HP:0003445)1.35683532
159Cone-rod dystrophy (HP:0000548)1.35105118
160Hyperaldosteronism (HP:0000859)1.34908483
161Polyuria (HP:0000103)1.30648821
162Highly arched eyebrow (HP:0002553)1.30049401
163Hypokalemic alkalosis (HP:0001949)1.28620787
164Holoprosencephaly (HP:0001360)1.28228440
165Dyschromatopsia (HP:0007641)1.25323691
166Widely spaced teeth (HP:0000687)1.22090617
167Specific learning disability (HP:0001328)1.21805391
168Macular degeneration (HP:0000608)1.21550671

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.34247630
2PDK45.34247630
3ICK5.04935210
4PRKD34.98807082
5TESK14.56132626
6FRK3.63659432
7PDK23.36458303
8MAP3K93.09606328
9MST43.09020549
10NEK22.80341341
11CDK122.56454551
12TAOK32.36232719
13MAP4K22.22838791
14TTK2.16360368
15MAPK152.13068057
16WEE12.00697877
17CDC71.99486342
18DYRK31.98001159
19MAP3K131.96817473
20WNK31.91544313
21INSRR1.88530393
22MARK11.82898993
23MUSK1.74697873
24ADRBK21.65659895
25EEF2K1.64380667
26DYRK1B1.63059420
27CASK1.61105894
28LATS11.58986103
29CHEK21.51195126
30MAPK131.47297677
31BMPR1B1.46624186
32PASK1.46564910
33PLK11.36107083
34PNCK1.33381565
35STK381.32614299
36OXSR11.31441655
37IRAK11.29427815
38EPHA31.26449249
39TSSK61.24891801
40TNK21.24154964
41STK31.23394951
42EPHA21.18862001
43CDK71.16115783
44ACVR1B1.15667227
45ATR1.13637300
46BMPR21.13388425
47BUB11.13141312
48TYRO31.12922157
49STK101.07116849
50FER1.05847657
51PTK2B1.04835843
52MAP3K71.04559459
53PLK21.03723881
54PAK31.01090467
55MTOR0.98889388
56ADRBK10.98402546
57CHEK10.97165364
58BCR0.96650551
59KIT0.95055063
60MAP3K40.93335433
61TRIB30.93293823
62WNK40.89689991
63MAP3K100.88714038
64BRSK20.88375251
65AURKB0.84728808
66PINK10.83088157
67PIM10.82833030
68ERBB20.82573144
69ERBB30.82490902
70ATM0.79842765
71CSK0.79674864
72MAP3K60.79177717
73TIE10.78490062
74TESK20.77343848
75PRKCE0.74434968
76RIPK40.73657453
77MAP3K80.73443535
78CDK40.72094759
79EPHB10.71700098
80NTRK30.71205529
81PIK3CG0.70785218
82NME10.68719388
83MAP3K110.68191113
84MATK0.67775049
85RPS6KA40.67620836
86TNIK0.67561728
87PRKCI0.67519087
88MAPKAPK30.66915857
89BRSK10.66202250
90KSR10.65784859
91TXK0.65457433
92IKBKB0.65044097
93AURKA0.64160290
94RPS6KB20.64062744
95NUAK10.63309834
96IRAK40.62764210
97PRKCQ0.62508157
98CDK20.59840360
99DAPK20.59743506
100FES0.58932697
101BTK0.58247724
102TEC0.58062883
103BMX0.57681983
104PKN10.56243328
105PRKAA20.55837387
106LYN0.55705515
107MAP2K10.55469792
108PRKAA10.55332921
109CSNK1G10.52236474
110PLK40.51901996
111HIPK20.50729868
112CHUK0.50268903
113MAP2K70.49578189
114PAK40.48740397
115LRRK20.48251208
116NEK10.48242990
117EPHA40.48184855
118TLK10.47771032
119BLK0.47492049
120RPS6KL10.46688358
121RPS6KC10.46688358
122VRK10.46204508
123CDK60.46122936
124RPS6KA10.45729890
125PAK10.45665517
126RPS6KA60.45494160
127SGK20.44979260
128AKT30.44144231
129CCNB10.44102420
130STK40.43715253
131CSF1R0.43624779
132RAF10.43548911
133ABL10.42814921
134DYRK20.42661666
135HCK0.42516733
136CDK10.42151292
137TGFBR10.42034356
138STK38L0.41034069
139NLK0.40908686
140CSNK1G20.40740604
141MAP3K20.40645938
142PRKD20.40117915
143ZAK0.40017412
144MARK30.39810581
145PDK10.39485459
146MAP2K60.38891036
147CSNK1G30.37769038
148PLK30.37134628
149TAOK10.37064964
150CSNK2A10.36191935
151CSNK1A1L0.35869244
152PRKACA0.35309685
153MAPK110.35227029
154BCKDK0.34692601
155MAP3K140.32876285
156YES10.32580121
157MKNK20.32044850
158RPS6KA20.30531359
159ARAF0.29658196
160EIF2AK10.29642979
161RPS6KA50.29575496
162MAP2K40.29331282
163GRK10.27979913
164STK390.27927301
165KSR20.27691958
166MAP2K20.27104069
167PRKCZ0.26892908
168CSNK2A20.26453951
169GSK3B0.25162073
170WNK10.25102380
171RPS6KB10.24863972
172MAPK10.24245687
173CSNK1D0.23542565
174GRK60.23332146
175AKT20.20868748
176MAPK140.20684759
177PAK20.19474711
178SRPK10.18923192

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.35207397
2Vitamin B6 metabolism_Homo sapiens_hsa007503.48935577
3Mismatch repair_Homo sapiens_hsa034303.23652577
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.10853578
5RNA transport_Homo sapiens_hsa030132.99280678
6Fanconi anemia pathway_Homo sapiens_hsa034602.97723519
7Chemical carcinogenesis_Homo sapiens_hsa052042.96731335
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.78730453
9Fatty acid biosynthesis_Homo sapiens_hsa000612.75667840
10Base excision repair_Homo sapiens_hsa034102.70745962
11Cell cycle_Homo sapiens_hsa041102.62862194
12Histidine metabolism_Homo sapiens_hsa003402.46825626
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45085913
14Basal transcription factors_Homo sapiens_hsa030222.39862314
15mRNA surveillance pathway_Homo sapiens_hsa030152.34180992
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.30596036
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30120945
18Homologous recombination_Homo sapiens_hsa034402.22231834
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.15316482
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.12807261
21beta-Alanine metabolism_Homo sapiens_hsa004102.12590650
22Spliceosome_Homo sapiens_hsa030402.06941233
23Nucleotide excision repair_Homo sapiens_hsa034202.03337749
24Selenocompound metabolism_Homo sapiens_hsa004502.02180616
25Linoleic acid metabolism_Homo sapiens_hsa005911.83989814
26Phenylalanine metabolism_Homo sapiens_hsa003601.81065479
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78608175
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77970130
29Fructose and mannose metabolism_Homo sapiens_hsa000511.74161387
30Oocyte meiosis_Homo sapiens_hsa041141.73865076
31Phototransduction_Homo sapiens_hsa047441.71904800
32Tyrosine metabolism_Homo sapiens_hsa003501.71198816
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.69111094
34RNA degradation_Homo sapiens_hsa030181.61935842
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59990145
36Dorso-ventral axis formation_Homo sapiens_hsa043201.57810691
37Nitrogen metabolism_Homo sapiens_hsa009101.56072428
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50131090
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48128947
40Pyrimidine metabolism_Homo sapiens_hsa002401.44047337
41Caffeine metabolism_Homo sapiens_hsa002321.41222353
42Glucagon signaling pathway_Homo sapiens_hsa049221.39674993
43Systemic lupus erythematosus_Homo sapiens_hsa053221.39537062
44Butanoate metabolism_Homo sapiens_hsa006501.39422196
45Olfactory transduction_Homo sapiens_hsa047401.35025428
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32754954
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.32447607
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31845964
49Retinol metabolism_Homo sapiens_hsa008301.31075128
50Pentose phosphate pathway_Homo sapiens_hsa000301.31035644
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30616375
52Peroxisome_Homo sapiens_hsa041461.30489937
53Purine metabolism_Homo sapiens_hsa002301.30322710
54p53 signaling pathway_Homo sapiens_hsa041151.29644824
55Hedgehog signaling pathway_Homo sapiens_hsa043401.26451422
56Glycerophospholipid metabolism_Homo sapiens_hsa005641.21608386
57Sphingolipid metabolism_Homo sapiens_hsa006001.19865446
58Antigen processing and presentation_Homo sapiens_hsa046121.19741104
59Tryptophan metabolism_Homo sapiens_hsa003801.17707230
60Collecting duct acid secretion_Homo sapiens_hsa049661.15515281
61Taste transduction_Homo sapiens_hsa047421.15348049
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13011320
63Salivary secretion_Homo sapiens_hsa049701.10755322
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10264290
65Nicotine addiction_Homo sapiens_hsa050331.09530931
66Asthma_Homo sapiens_hsa053101.08854528
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08728937
68Pyruvate metabolism_Homo sapiens_hsa006201.07419273
69Fatty acid degradation_Homo sapiens_hsa000711.07325512
70Circadian rhythm_Homo sapiens_hsa047101.01818351
71Cysteine and methionine metabolism_Homo sapiens_hsa002701.01135044
72Basal cell carcinoma_Homo sapiens_hsa052171.00141945
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99378586
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99174293
75Type I diabetes mellitus_Homo sapiens_hsa049400.97172682
76Glycerolipid metabolism_Homo sapiens_hsa005610.97016626
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.96628639
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.95086727
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94590528
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91975337
81Viral carcinogenesis_Homo sapiens_hsa052030.91141694
82One carbon pool by folate_Homo sapiens_hsa006700.91136504
83Biosynthesis of amino acids_Homo sapiens_hsa012300.90503271
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89473308
85RNA polymerase_Homo sapiens_hsa030200.88833266
86Non-homologous end-joining_Homo sapiens_hsa034500.88249967
87Serotonergic synapse_Homo sapiens_hsa047260.88061269
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86739395
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86705947
90mTOR signaling pathway_Homo sapiens_hsa041500.86194667
91Arachidonic acid metabolism_Homo sapiens_hsa005900.81496402
92Ribosome_Homo sapiens_hsa030100.80798091
93ABC transporters_Homo sapiens_hsa020100.78370844
94Allograft rejection_Homo sapiens_hsa053300.77493245
95Hematopoietic cell lineage_Homo sapiens_hsa046400.75177553
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74944129
97AMPK signaling pathway_Homo sapiens_hsa041520.74704656
98Staphylococcus aureus infection_Homo sapiens_hsa051500.74239211
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73963435
100Herpes simplex infection_Homo sapiens_hsa051680.72114615
101Ovarian steroidogenesis_Homo sapiens_hsa049130.71787324
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71586822
103Notch signaling pathway_Homo sapiens_hsa043300.71327830
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.71081868
105HTLV-I infection_Homo sapiens_hsa051660.69850350
106Hippo signaling pathway_Homo sapiens_hsa043900.68054310
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67435401
108Alcoholism_Homo sapiens_hsa050340.67061963
109Glutathione metabolism_Homo sapiens_hsa004800.66924042
110Autoimmune thyroid disease_Homo sapiens_hsa053200.66514405
111Protein export_Homo sapiens_hsa030600.66266633
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64249812
113Graft-versus-host disease_Homo sapiens_hsa053320.62220913
114Sulfur relay system_Homo sapiens_hsa041220.62073170
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61719955
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60107090
117Epstein-Barr virus infection_Homo sapiens_hsa051690.59796390
118Oxidative phosphorylation_Homo sapiens_hsa001900.58066997
119Insulin secretion_Homo sapiens_hsa049110.57723292
120Carbon metabolism_Homo sapiens_hsa012000.57520842
121Cocaine addiction_Homo sapiens_hsa050300.56548186
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56389301
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55289427
124Ether lipid metabolism_Homo sapiens_hsa005650.53532525
125Regulation of autophagy_Homo sapiens_hsa041400.53350436
126Rheumatoid arthritis_Homo sapiens_hsa053230.53088573
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52901080
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52848352
129Galactose metabolism_Homo sapiens_hsa000520.52734137
130Legionellosis_Homo sapiens_hsa051340.52510251
131Huntingtons disease_Homo sapiens_hsa050160.51183708
132Calcium signaling pathway_Homo sapiens_hsa040200.50613468
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50156985
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50123776
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49660216
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.47659246
137Estrogen signaling pathway_Homo sapiens_hsa049150.46565682
138Propanoate metabolism_Homo sapiens_hsa006400.46094407
139Circadian entrainment_Homo sapiens_hsa047130.45541056
140Long-term depression_Homo sapiens_hsa047300.45445764
141Inositol phosphate metabolism_Homo sapiens_hsa005620.45108577
142Wnt signaling pathway_Homo sapiens_hsa043100.44823096
143Acute myeloid leukemia_Homo sapiens_hsa052210.43493117
144Fat digestion and absorption_Homo sapiens_hsa049750.42954427
145Proteasome_Homo sapiens_hsa030500.42766816
146Primary bile acid biosynthesis_Homo sapiens_hsa001200.42371886
147Folate biosynthesis_Homo sapiens_hsa007900.42048567
148cAMP signaling pathway_Homo sapiens_hsa040240.41855132
149PPAR signaling pathway_Homo sapiens_hsa033200.41684321
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.41629264
151Osteoclast differentiation_Homo sapiens_hsa043800.41387981
152Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41131849
153African trypanosomiasis_Homo sapiens_hsa051430.40646299
154Mineral absorption_Homo sapiens_hsa049780.40352636
155Malaria_Homo sapiens_hsa051440.37052375
156Primary immunodeficiency_Homo sapiens_hsa053400.35960382
157Lysosome_Homo sapiens_hsa041420.35556981
158Insulin resistance_Homo sapiens_hsa049310.34682724
159Adipocytokine signaling pathway_Homo sapiens_hsa049200.34123912
160Lysine degradation_Homo sapiens_hsa003100.33807837
161Morphine addiction_Homo sapiens_hsa050320.32409695
162Leishmaniasis_Homo sapiens_hsa051400.32350797
163Fatty acid metabolism_Homo sapiens_hsa012120.31608333
164Maturity onset diabetes of the young_Homo sapiens_hsa049500.31566566
165MicroRNAs in cancer_Homo sapiens_hsa052060.31437333
166Prostate cancer_Homo sapiens_hsa052150.30791673
167Small cell lung cancer_Homo sapiens_hsa052220.28045745
168Drug metabolism - other enzymes_Homo sapiens_hsa009830.23532521
169TGF-beta signaling pathway_Homo sapiens_hsa043500.23478580
170Bladder cancer_Homo sapiens_hsa052190.21169734
171Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21135811
172Metabolic pathways_Homo sapiens_hsa011000.20838853
173Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19401914

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