RFX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Multiple transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.45215465
2* cilium movement (GO:0003341)7.69936824
3* epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.59096914
4* cilium or flagellum-dependent cell motility (GO:0001539)7.53141665
5* epithelial cilium movement (GO:0003351)7.42289751
6intraciliary transport (GO:0042073)5.53927243
7motile cilium assembly (GO:0044458)5.33644647
8axoneme assembly (GO:0035082)5.29391007
9pyrimidine nucleobase catabolic process (GO:0006208)5.00012871
10regulation of cilium movement (GO:0003352)4.74843451
11neuron cell-cell adhesion (GO:0007158)4.67577448
12* cilium organization (GO:0044782)4.64131432
13* cilium assembly (GO:0042384)4.59599378
14axonal fasciculation (GO:0007413)4.59040970
15nonmotile primary cilium assembly (GO:0035058)4.37156097
16presynaptic membrane assembly (GO:0097105)4.34100731
17protein localization to cilium (GO:0061512)4.26250935
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.25511935
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.24334106
20central nervous system projection neuron axonogenesis (GO:0021952)4.23115960
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.16334627
22ventricular system development (GO:0021591)4.15456186
23cilium morphogenesis (GO:0060271)4.12701674
24regulation of short-term neuronal synaptic plasticity (GO:0048172)4.11836943
25locomotory exploration behavior (GO:0035641)4.07844296
26protein localization to synapse (GO:0035418)4.05740626
27neuron recognition (GO:0008038)4.05412591
28neurotransmitter-gated ion channel clustering (GO:0072578)4.04035075
29neuronal stem cell maintenance (GO:0097150)4.02374590
30dendritic spine morphogenesis (GO:0060997)3.99248069
31glutamate receptor signaling pathway (GO:0007215)3.93364258
32presynaptic membrane organization (GO:0097090)3.91411920
33nucleobase catabolic process (GO:0046113)3.89845689
34synaptic transmission, glutamatergic (GO:0035249)3.87752198
35regulation of glutamate receptor signaling pathway (GO:1900449)3.87637307
36vocalization behavior (GO:0071625)3.86768969
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80507466
38left/right axis specification (GO:0070986)3.76142301
39left/right pattern formation (GO:0060972)3.74954872
40microtubule bundle formation (GO:0001578)3.73277306
41postsynaptic membrane organization (GO:0001941)3.71788509
42neuron fate determination (GO:0048664)3.67876814
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.65197096
44* cellular component assembly involved in morphogenesis (GO:0010927)3.62667764
45dendrite morphogenesis (GO:0048813)3.61542286
46neural tube formation (GO:0001841)3.57826771
47innervation (GO:0060384)3.52938769
48calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.51387273
49limb development (GO:0060173)3.51121962
50appendage development (GO:0048736)3.51121962
51smoothened signaling pathway (GO:0007224)3.49279572
52glutamate secretion (GO:0014047)3.48974458
53exploration behavior (GO:0035640)3.47077610
54synaptic vesicle exocytosis (GO:0016079)3.46609996
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.41559165
56central nervous system neuron axonogenesis (GO:0021955)3.41354415
57forebrain neuron differentiation (GO:0021879)3.40359227
58synaptic vesicle maturation (GO:0016188)3.39507690
59retinal rod cell development (GO:0046548)3.35286817
60regulation of neuronal synaptic plasticity (GO:0048168)3.35045742
61neuronal action potential propagation (GO:0019227)3.34661376
62neuron-neuron synaptic transmission (GO:0007270)3.34030799
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32260586
64olfactory bulb development (GO:0021772)3.32225603
65limb bud formation (GO:0060174)3.31213058
66startle response (GO:0001964)3.29047364
67mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.27830473
68positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.27830473
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.25539373
70regulation of synaptic vesicle exocytosis (GO:2000300)3.23458843
71cerebral cortex radially oriented cell migration (GO:0021799)3.22059908
72* microtubule-based movement (GO:0007018)3.17319231
73regulation of long-term neuronal synaptic plasticity (GO:0048169)3.16844840
74protein polyglutamylation (GO:0018095)3.13960590
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.12590949
76long-term memory (GO:0007616)3.09108764
77regulation of excitatory postsynaptic membrane potential (GO:0060079)3.08758742
78auditory behavior (GO:0031223)3.08400174
79synaptic vesicle docking involved in exocytosis (GO:0016081)3.05647150
80behavioral response to nicotine (GO:0035095)3.05313070
81establishment of nucleus localization (GO:0040023)3.03054499
82lateral sprouting from an epithelium (GO:0060601)3.02724127
83L-amino acid import (GO:0043092)2.99781478
84regulation of microtubule-based movement (GO:0060632)2.99226266
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.98070389
86layer formation in cerebral cortex (GO:0021819)2.97960395
87somite development (GO:0061053)2.97611001
88regulation of axon guidance (GO:1902667)2.97020117
89negative regulation of oligodendrocyte differentiation (GO:0048715)2.96340392
90regulation of collateral sprouting (GO:0048670)2.95849078
91neuronal ion channel clustering (GO:0045161)2.95589943
92regulation of postsynaptic membrane potential (GO:0060078)2.94760277
93behavioral defense response (GO:0002209)2.93260441
94behavioral fear response (GO:0001662)2.93260441
95* cell projection assembly (GO:0030031)2.91913506
96positive regulation of synapse maturation (GO:0090129)2.91526413
97regulation of synaptic transmission, glutamatergic (GO:0051966)2.90674626
98establishment of mitochondrion localization (GO:0051654)2.90062410
99regulation of dendritic spine morphogenesis (GO:0061001)2.90030311
100transmission of nerve impulse (GO:0019226)2.89552777
101synapse assembly (GO:0007416)2.88632436
102long-term synaptic potentiation (GO:0060291)2.86965853
103regulation of synaptic vesicle transport (GO:1902803)2.86819917
104determination of left/right symmetry (GO:0007368)2.85724251
105mechanosensory behavior (GO:0007638)2.85654358
106dendritic spine organization (GO:0097061)2.85574693
107negative regulation of axon guidance (GO:1902668)2.85530449
108regulation of synaptic plasticity (GO:0048167)2.85421568
109positive regulation of membrane potential (GO:0045838)2.84329655
110cerebellar granule cell differentiation (GO:0021707)2.83517092
111regulation of axon extension involved in axon guidance (GO:0048841)2.81204267
112response to auditory stimulus (GO:0010996)2.80612253
113dendrite development (GO:0016358)2.80277564
114regulation of respiratory system process (GO:0044065)2.78045696
115cochlea development (GO:0090102)2.77616833
116regulation of development, heterochronic (GO:0040034)2.76530218
117determination of bilateral symmetry (GO:0009855)2.76407009
118cell migration in hindbrain (GO:0021535)2.76273036
119synaptic vesicle endocytosis (GO:0048488)2.74277887
120regulation of synapse structural plasticity (GO:0051823)2.73965731
121retinal ganglion cell axon guidance (GO:0031290)2.73954835
122retinal cone cell development (GO:0046549)2.73788151
123positive regulation of dendritic spine development (GO:0060999)2.72818368
124axon ensheathment in central nervous system (GO:0032291)2.72265126
125central nervous system myelination (GO:0022010)2.72265126
126photoreceptor cell maintenance (GO:0045494)2.70903745
127positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.70902898
128negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.70708310
129spinal cord development (GO:0021510)2.68517392
130microtubule depolymerization (GO:0007019)2.68271691
131inner ear receptor cell development (GO:0060119)2.68128703
132specification of symmetry (GO:0009799)2.68127965
133regulation of synapse maturation (GO:0090128)2.67640163
134membrane depolarization during action potential (GO:0086010)2.67080166
135neuron projection extension involved in neuron projection guidance (GO:1902284)2.65145746
136axon extension involved in axon guidance (GO:0048846)2.65145746
137fear response (GO:0042596)2.64191285
138negative regulation of axon extension (GO:0030517)2.63293719
139axonogenesis (GO:0007409)2.63253620
140regulation of timing of cell differentiation (GO:0048505)2.62736034
141cerebellar Purkinje cell differentiation (GO:0021702)2.62277569
142centriole replication (GO:0007099)2.61733303
143cell differentiation in spinal cord (GO:0021515)2.59961115
144regulation of oligodendrocyte differentiation (GO:0048713)2.59225197
145learning (GO:0007612)2.58964221
146hindbrain development (GO:0030902)2.58020675
147axon extension (GO:0048675)2.57850881
148positive regulation of synapse assembly (GO:0051965)2.57473586
149negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57284342
150spinal cord association neuron differentiation (GO:0021527)2.56818894
151negative regulation of axon extension involved in axon guidance (GO:0048843)2.56617439
152neuron migration (GO:0001764)2.55823732
153membrane depolarization (GO:0051899)2.55601489
154gamma-aminobutyric acid signaling pathway (GO:0007214)2.55272308
155negative regulation of axonogenesis (GO:0050771)2.55258510
156regulation of synapse assembly (GO:0051963)2.54882482
157response to histamine (GO:0034776)2.54848951
158positive regulation of mitochondrial fission (GO:0090141)2.54736399
159positive regulation of synaptic transmission, GABAergic (GO:0032230)2.54496071
160negative regulation of neurotransmitter transport (GO:0051589)2.53572600
161synapse organization (GO:0050808)2.52019437
162regulation of dendritic spine development (GO:0060998)2.51131919
163spinal cord motor neuron differentiation (GO:0021522)2.47828259
164C4-dicarboxylate transport (GO:0015740)2.47287072
165microtubule-based transport (GO:0010970)2.45553957
166establishment of planar polarity (GO:0001736)2.44663364
167establishment of tissue polarity (GO:0007164)2.44663364
168dorsal/ventral pattern formation (GO:0009953)2.44575417
169positive regulation of oligodendrocyte differentiation (GO:0048714)2.42872712
170cytoskeleton-dependent intracellular transport (GO:0030705)2.41285237
171homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.41273423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.75325667
2GBX2_23144817_ChIP-Seq_PC3_Human4.15808588
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68199305
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65551181
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58205505
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.49859593
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.34624563
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34351265
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30676765
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30458311
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30458311
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26643565
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23581837
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20962377
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17487614
16VDR_22108803_ChIP-Seq_LS180_Human2.17053698
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.11224025
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11152722
19* REST_21632747_ChIP-Seq_MESCs_Mouse2.08367668
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.07451565
21DROSHA_22980978_ChIP-Seq_HELA_Human2.06256120
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05597371
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00441965
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98337389
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96093316
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.95613103
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.95411046
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91428272
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.87960876
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.87063313
31P300_19829295_ChIP-Seq_ESCs_Human1.85169517
32* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84527044
33* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83256551
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83057499
35IGF1R_20145208_ChIP-Seq_DFB_Human1.82924654
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82904927
37TAF15_26573619_Chip-Seq_HEK293_Human1.79933629
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.79585214
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78503852
40FUS_26573619_Chip-Seq_HEK293_Human1.74199367
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73447270
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72210254
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.70365384
44AR_21572438_ChIP-Seq_LNCaP_Human1.68532942
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.67354551
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.56375142
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54946727
48* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54683775
49STAT3_23295773_ChIP-Seq_U87_Human1.51987490
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51977949
51RNF2_27304074_Chip-Seq_NSC_Mouse1.50830076
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.49621524
53* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44771589
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43041755
55CBP_20019798_ChIP-Seq_JUKART_Human1.43021428
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43021428
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42053959
58* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41546813
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.40861823
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40456730
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39025556
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36655212
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36655212
64EWS_26573619_Chip-Seq_HEK293_Human1.33807887
65AR_25329375_ChIP-Seq_VCAP_Human1.33102844
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.31162171
67TCF4_23295773_ChIP-Seq_U87_Human1.31132411
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.30601977
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30305114
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29697056
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29312403
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.28775399
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28411705
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28061070
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26895148
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25268436
77BCAT_22108803_ChIP-Seq_LS180_Human1.25020759
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24626831
79* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22571711
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21525543
81* TAL1_26923725_Chip-Seq_HPCs_Mouse1.20268412
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.20074345
83* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20032522
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19879160
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.19493334
86ZNF274_21170338_ChIP-Seq_K562_Hela1.19484028
87TCF4_22108803_ChIP-Seq_LS180_Human1.19244217
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.18983230
89AR_19668381_ChIP-Seq_PC3_Human1.18698499
90* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18684895
91* RUNX2_22187159_ChIP-Seq_PCA_Human1.17969392
92AHR_22903824_ChIP-Seq_MCF-7_Human1.16963126
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16959623
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.16399902
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15654375
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14633167
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.14461178
98P53_22387025_ChIP-Seq_ESCs_Mouse1.13836719
99* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13525780
100ER_23166858_ChIP-Seq_MCF-7_Human1.11543755
101SOX9_26525672_Chip-Seq_HEART_Mouse1.10855090
102* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09456824
103* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09129458
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07454761
105TP53_18474530_ChIP-ChIP_U2OS_Human1.07067134
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07058461
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.06749688
108P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06575446
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.05102547
110IRF1_19129219_ChIP-ChIP_H3396_Human1.04308262
111* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04184299
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02954544
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02492946
114GATA1_26923725_Chip-Seq_HPCs_Mouse1.00813721
115LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00778000
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00447527
117BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00374482
118* TP53_16413492_ChIP-PET_HCT116_Human0.99066773
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98042825
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97219117
121SOX2_18555785_Chip-Seq_ESCs_Mouse0.95891019

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.04552801
2MP0003880_abnormal_central_pattern4.31284926
3MP0002653_abnormal_ependyma_morphology3.29569883
4MP0003635_abnormal_synaptic_transmissio3.15883791
5MP0003136_yellow_coat_color3.00900284
6MP0004270_analgesia2.93248791
7MP0000778_abnormal_nervous_system2.75914302
8MP0002063_abnormal_learning/memory/cond2.65785189
9MP0005423_abnormal_somatic_nervous2.58150685
10MP0009745_abnormal_behavioral_response2.49683765
11MP0001486_abnormal_startle_reflex2.38301936
12MP0002572_abnormal_emotion/affect_behav2.32405283
13MP0003787_abnormal_imprinting2.29350363
14MP0002064_seizures2.24163504
15MP0005646_abnormal_pituitary_gland2.18279433
16MP0006292_abnormal_olfactory_placode2.17114927
17MP0005248_abnormal_Harderian_gland2.13607064
18MP0009780_abnormal_chondrocyte_physiolo2.08157286
19MP0001984_abnormal_olfaction1.96945970
20MP0001188_hyperpigmentation1.92128572
21* MP0004133_heterotaxia1.91328973
22MP0000631_abnormal_neuroendocrine_gland1.87846129
23MP0004885_abnormal_endolymph1.86430762
24MP0002184_abnormal_innervation1.82603205
25MP0002734_abnormal_mechanical_nocicepti1.82240248
26MP0002272_abnormal_nervous_system1.81618601
27MP0001968_abnormal_touch/_nociception1.79650158
28MP0002557_abnormal_social/conspecific_i1.78619550
29MP0005171_absent_coat_pigmentation1.72933885
30MP0002735_abnormal_chemical_nociception1.70708927
31MP0001502_abnormal_circadian_rhythm1.69873005
32MP0000569_abnormal_digit_pigmentation1.66777901
33MP0002067_abnormal_sensory_capabilities1.65700700
34MP0000566_synostosis1.58813438
35MP0009046_muscle_twitch1.55272002
36MP0002882_abnormal_neuron_morphology1.54813613
37MP0005645_abnormal_hypothalamus_physiol1.49943654
38MP0000955_abnormal_spinal_cord1.49892161
39MP0001293_anophthalmia1.48514757
40MP0000383_abnormal_hair_follicle1.47919263
41MP0008569_lethality_at_weaning1.45422294
42MP0005551_abnormal_eye_electrophysiolog1.45173018
43MP0003122_maternal_imprinting1.44581916
44MP0001440_abnormal_grooming_behavior1.43164422
45MP0004811_abnormal_neuron_physiology1.41955609
46MP0005499_abnormal_olfactory_system1.41476576
47MP0005394_taste/olfaction_phenotype1.41476576
48MP0005386_behavior/neurological_phenoty1.41057091
49MP0004924_abnormal_behavior1.41057091
50MP0002928_abnormal_bile_duct1.40371479
51MP0002822_catalepsy1.37917989
52MP0003283_abnormal_digestive_organ1.37893771
53MP0002638_abnormal_pupillary_reflex1.36457685
54MP0008789_abnormal_olfactory_epithelium1.35722312
55MP0003890_abnormal_embryonic-extraembry1.35430352
56MP0002152_abnormal_brain_morphology1.35364868
57MP0001485_abnormal_pinna_reflex1.34015211
58MP0003121_genomic_imprinting1.30756837
59MP0005187_abnormal_penis_morphology1.29844573
60MP0002751_abnormal_autonomic_nervous1.29395480
61MP0006276_abnormal_autonomic_nervous1.27641413
62MP0004742_abnormal_vestibular_system1.24756244
63MP0001529_abnormal_vocalization1.23875302
64MP0002876_abnormal_thyroid_physiology1.23829864
65MP0001299_abnormal_eye_distance/1.22793179
66MP0006072_abnormal_retinal_apoptosis1.22655714
67MP0002733_abnormal_thermal_nociception1.20657714
68MP0002736_abnormal_nociception_after1.18681302
69MP0001970_abnormal_pain_threshold1.16092890
70MP0003861_abnormal_nervous_system1.15643158
71MP0005195_abnormal_posterior_eye1.14085189
72MP0000026_abnormal_inner_ear1.14018996
73MP0001501_abnormal_sleep_pattern1.13314414
74MP0002066_abnormal_motor_capabilities/c1.12945363
75MP0002752_abnormal_somatic_nervous1.12553218
76MP0005391_vision/eye_phenotype1.11315280
77MP0001905_abnormal_dopamine_level1.10604165
78MP0003938_abnormal_ear_development1.10072670
79MP0002234_abnormal_pharynx_morphology1.10063920
80MP0003119_abnormal_digestive_system1.08582345
81MP0001963_abnormal_hearing_physiology1.07047062
82MP0004043_abnormal_pH_regulation1.06389240
83MP0002282_abnormal_trachea_morphology1.04760996
84MP0003183_abnormal_peptide_metabolism1.02746481
85MP0001286_abnormal_eye_development1.02525726
86MP0003634_abnormal_glial_cell1.00004727
87MP0003633_abnormal_nervous_system0.98514816
88MP0010030_abnormal_orbit_morphology0.98404537
89MP0000647_abnormal_sebaceous_gland0.97657137
90MP0005253_abnormal_eye_physiology0.97347882
91MP0005409_darkened_coat_color0.97183583
92MP0003878_abnormal_ear_physiology0.96772391
93MP0005377_hearing/vestibular/ear_phenot0.96772391
94MP0001346_abnormal_lacrimal_gland0.91129231
95MP0004142_abnormal_muscle_tone0.90859846
96MP0010678_abnormal_skin_adnexa0.88605830
97MP0002102_abnormal_ear_morphology0.87996917
98MP0003631_nervous_system_phenotype0.86250257
99MP0000049_abnormal_middle_ear0.85825599
100MP0002229_neurodegeneration0.83355140
101MP0004858_abnormal_nervous_system0.83035376
102MP0003315_abnormal_perineum_morphology0.82760952
103MP0003879_abnormal_hair_cell0.82725224
104MP0003137_abnormal_impulse_conducting0.81363745
105MP0001177_atelectasis0.81310302
106MP0000534_abnormal_ureter_morphology0.81255573
107MP0003942_abnormal_urinary_system0.80779271
108MP0001324_abnormal_eye_pigmentation0.79731708
109MP0003755_abnormal_palate_morphology0.78565398
110MP0003690_abnormal_glial_cell0.78540562
111MP0002277_abnormal_respiratory_mucosa0.77803955
112MP0002233_abnormal_nose_morphology0.76548997
113MP0002909_abnormal_adrenal_gland0.75497758
114MP0000681_abnormal_thyroid_gland0.75283424
115MP0002069_abnormal_eating/drinking_beha0.74884701
116MP0003698_abnormal_male_reproductive0.74745604
117MP0002697_abnormal_eye_size0.73232545
118MP0008995_early_reproductive_senescence0.73028793
119MP0002116_abnormal_craniofacial_bone0.72851604
120MP0008877_abnormal_DNA_methylation0.72639143
121MP0002095_abnormal_skin_pigmentation0.71069478
122MP0002938_white_spotting0.69889797
123MP0003937_abnormal_limbs/digits/tail_de0.68896455

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.38805024
2Rhinitis (HP:0012384)5.23648097
3Focal motor seizures (HP:0011153)4.57943088
4Pancreatic cysts (HP:0001737)3.90709381
5Epileptic encephalopathy (HP:0200134)3.70080223
6Bronchiectasis (HP:0002110)3.62680734
7Chronic bronchitis (HP:0004469)3.41714257
8Abnormality of the renal medulla (HP:0100957)3.35531972
9Focal seizures (HP:0007359)3.34647684
10Cystic liver disease (HP:0006706)3.16082777
11Occipital encephalocele (HP:0002085)3.14335962
12Postaxial foot polydactyly (HP:0001830)3.11633653
13Hyperventilation (HP:0002883)3.06043672
14Progressive cerebellar ataxia (HP:0002073)3.02501618
15Myokymia (HP:0002411)2.96968033
16Febrile seizures (HP:0002373)2.91791738
17Broad-based gait (HP:0002136)2.88651348
18Drooling (HP:0002307)2.82205353
19Excessive salivation (HP:0003781)2.82205353
20Aplasia/Hypoplasia of the tongue (HP:0010295)2.75003696
21Tubulointerstitial nephritis (HP:0001970)2.72994320
22Protruding tongue (HP:0010808)2.65744765
23Volvulus (HP:0002580)2.63685229
24Anencephaly (HP:0002323)2.60618588
25Truncal ataxia (HP:0002078)2.59782849
26Gait imbalance (HP:0002141)2.52153259
27Megalencephaly (HP:0001355)2.48907606
28Chronic hepatic failure (HP:0100626)2.43032724
29Congenital hepatic fibrosis (HP:0002612)2.40868584
30Tubular atrophy (HP:0000092)2.37566893
31Sclerocornea (HP:0000647)2.35242368
32Preaxial hand polydactyly (HP:0001177)2.31295647
33Nasal polyposis (HP:0100582)2.29776824
34Intestinal atresia (HP:0011100)2.26211039
35Cutaneous finger syndactyly (HP:0010554)2.24139267
36Widely spaced teeth (HP:0000687)2.23499353
37Blue irides (HP:0000635)2.23190932
38Dialeptic seizures (HP:0011146)2.22398177
39Chronic sinusitis (HP:0011109)2.22365085
40Polyphagia (HP:0002591)2.22194465
41Congenital primary aphakia (HP:0007707)2.19995303
42Epileptiform EEG discharges (HP:0011182)2.18659145
43Supernumerary spleens (HP:0009799)2.18200941
44Gaze-evoked nystagmus (HP:0000640)2.17342626
45Thickened helices (HP:0000391)2.16394156
46Absent speech (HP:0001344)2.16298173
47Abnormality of the renal cortex (HP:0011035)2.15260129
48Atonic seizures (HP:0010819)2.15121553
49Aplasia involving bones of the extremities (HP:0009825)2.13650297
50Aplasia involving bones of the upper limbs (HP:0009823)2.13650297
51Aplasia of the phalanges of the hand (HP:0009802)2.13650297
52Medial flaring of the eyebrow (HP:0010747)2.13503635
53Broad foot (HP:0001769)2.11167465
54Absence seizures (HP:0002121)2.11022248
55Obsessive-compulsive behavior (HP:0000722)2.08632760
56Action tremor (HP:0002345)2.08441042
57Aqueductal stenosis (HP:0002410)2.08370557
58Abnormal biliary tract physiology (HP:0012439)2.07987123
59Bile duct proliferation (HP:0001408)2.07987123
60Anophthalmia (HP:0000528)2.07234205
61Cutaneous syndactyly (HP:0012725)2.05463962
62Absent/shortened dynein arms (HP:0200106)2.03067032
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.03067032
64Nephrogenic diabetes insipidus (HP:0009806)2.02415757
65Genetic anticipation (HP:0003743)2.02303934
66Tented upper lip vermilion (HP:0010804)2.02168414
67Abnormality of salivation (HP:0100755)2.02066298
68Infertility (HP:0000789)2.00581459
69Molar tooth sign on MRI (HP:0002419)2.00250543
70Abnormality of midbrain morphology (HP:0002418)2.00250543
71Genital tract atresia (HP:0001827)1.99929087
72Male pseudohermaphroditism (HP:0000037)1.99273520
73Inappropriate behavior (HP:0000719)1.98157849
74EEG with generalized epileptiform discharges (HP:0011198)1.97394940
75True hermaphroditism (HP:0010459)1.97086744
76Colon cancer (HP:0003003)1.95901005
77Stereotypic behavior (HP:0000733)1.95597505
78Tubulointerstitial abnormality (HP:0001969)1.94777914
79Septo-optic dysplasia (HP:0100842)1.94762211
80Abnormal ciliary motility (HP:0012262)1.94575836
81Vaginal atresia (HP:0000148)1.94100967
82Fair hair (HP:0002286)1.91013763
83Aplasia/Hypoplasia of the tibia (HP:0005772)1.90379835
84Generalized hypopigmentation of hair (HP:0011358)1.89967881
85Ankyloglossia (HP:0010296)1.88241154
86Agitation (HP:0000713)1.87975059
87Anteriorly placed anus (HP:0001545)1.87660922
88Pancreatic fibrosis (HP:0100732)1.87498560
89Hepatoblastoma (HP:0002884)1.87423835
90Abnormality of the labia minora (HP:0012880)1.86488865
91Hypsarrhythmia (HP:0002521)1.85963824
92Recurrent sinusitis (HP:0011108)1.85580466
93Impaired vibration sensation in the lower limbs (HP:0002166)1.85249623
94Hemiparesis (HP:0001269)1.85097582
95Decreased circulating renin level (HP:0003351)1.84448752
96Exotropia (HP:0000577)1.83886871
97Oculomotor apraxia (HP:0000657)1.83441256
98Scanning speech (HP:0002168)1.81750960
99Generalized tonic-clonic seizures (HP:0002069)1.81387377
100Nephronophthisis (HP:0000090)1.80703700
101Amblyopia (HP:0000646)1.80456536
102Dysdiadochokinesis (HP:0002075)1.78757260
103Specific learning disability (HP:0001328)1.78589558
104Gastrointestinal atresia (HP:0002589)1.78372034
105Decreased lacrimation (HP:0000633)1.78258375
106Dysmetria (HP:0001310)1.78187111
107Gastroesophageal reflux (HP:0002020)1.77011300
108Prominent nasal bridge (HP:0000426)1.76288598
109Abnormal respiratory motile cilium physiology (HP:0012261)1.75992804
110Short tibia (HP:0005736)1.75573409
111Papilledema (HP:0001085)1.75541715
112Macroorchidism (HP:0000053)1.73632232
113Alacrima (HP:0000522)1.73444165
114Absent septum pellucidum (HP:0001331)1.73282669
115Decreased testicular size (HP:0008734)1.73141500
116Ankle clonus (HP:0011448)1.72010760
117Abnormal hair whorl (HP:0010721)1.71484924
118Papillary thyroid carcinoma (HP:0002895)1.71204748
119Impaired smooth pursuit (HP:0007772)1.71172189
120Abnormality of the corticospinal tract (HP:0002492)1.70271937
121Aplasia/Hypoplasia of the lens (HP:0008063)1.69648785
122Renal hypoplasia (HP:0000089)1.68771235
123Polydipsia (HP:0001959)1.68352070
124Abnormal drinking behavior (HP:0030082)1.68352070
125Chorioretinal coloboma (HP:0000567)1.67639763
126Median cleft lip (HP:0000161)1.67590845
127Deeply set eye (HP:0000490)1.66748522
128Short foot (HP:0001773)1.66672976
129Visual hallucinations (HP:0002367)1.66376674
130Micropenis (HP:0000054)1.65480934
131Furrowed tongue (HP:0000221)1.65182546
132Autism (HP:0000717)1.65131293
133Oligodactyly (HP:0012165)1.65012072
134Aganglionic megacolon (HP:0002251)1.64285217
135Neurofibrillary tangles (HP:0002185)1.64173809
136Abnormality of incisor morphology (HP:0011063)1.63035000
137Intellectual disability, moderate (HP:0002342)1.62642190
138Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.62589599
139Degeneration of the lateral corticospinal tracts (HP:0002314)1.62589599
140Abnormal respiratory motile cilium morphology (HP:0005938)1.61939957
141Abnormal respiratory epithelium morphology (HP:0012253)1.61939957
142Optic nerve hypoplasia (HP:0000609)1.61761737
143Poor coordination (HP:0002370)1.61414276
144Retinal dysplasia (HP:0007973)1.61349852
145Oligodactyly (hands) (HP:0001180)1.61277787
146Postaxial hand polydactyly (HP:0001162)1.60520492
147Cupped ear (HP:0000378)1.60461201
148Poor eye contact (HP:0000817)1.60254978
149Narrow forehead (HP:0000341)1.60231932
150Lissencephaly (HP:0001339)1.59383336
151Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.58423336
152Abnormality of the nasal mucosa (HP:0000433)1.58310370
153Multicystic kidney dysplasia (HP:0000003)1.58267406
154Bronchitis (HP:0012387)1.56118131
155Rib fusion (HP:0000902)1.54129565
156Highly arched eyebrow (HP:0002553)1.53686848
157Holoprosencephaly (HP:0001360)1.53647810
158Dandy-Walker malformation (HP:0001305)1.50671750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.15253304
2TNIK3.82216707
3MAPK153.73974825
4MARK13.67965008
5EPHA43.64943910
6MAP4K23.46737609
7SIK33.07690580
8KSR12.87671438
9NTRK22.67170729
10CASK2.57552747
11PRPF4B2.36756380
12BCR2.26758875
13MAPK132.23709799
14MAP3K42.05129011
15MINK12.01867888
16MAP2K71.99368651
17FRK1.94246226
18EPHA31.72083895
19TRIM281.69294951
20UHMK11.60252195
21MAP3K91.60231824
22PINK11.57382212
23SGK21.50494676
24SGK2231.48522000
25SGK4941.48522000
26FGFR21.41923367
27ERBB31.34868818
28DYRK31.30348878
29PAK61.27184491
30WNK31.24553889
31NTRK11.22854731
32CDK51.19424161
33PLK21.17761864
34CSNK1G11.16195446
35CAMK2B1.13073451
36PRKD31.06277924
37DYRK1B1.05802490
38MAP3K21.05109866
39EPHB21.04292755
40DAPK11.04230234
41DAPK21.04117152
42MKNK11.01635526
43ADRBK21.00976679
44DYRK1A1.00899152
45INSRR1.00769787
46MAP2K40.97653832
47SGK30.96150655
48CSNK1G20.94003893
49YES10.93693078
50BRD40.93175897
51MARK20.91236126
52CAMK2A0.90983154
53NEK60.90556883
54PHKG10.89097942
55PHKG20.89097942
56PRKCG0.88904487
57SGK10.87865744
58STK38L0.86128169
59CAMKK20.85365457
60CAMK1G0.85242590
61KSR20.82537188
62CDK180.80251519
63CDK30.78995407
64WNK40.78936988
65PNCK0.78163471
66PTK2B0.77536813
67DYRK20.75813413
68SIK20.73436133
69OXSR10.72819488
70GRK10.72398378
71NUAK10.71154023
72BCKDK0.71135914
73MUSK0.69706201
74CDC42BPA0.68968674
75PAK30.67819469
76RPS6KA40.67254403
77CCNB10.65451075
78CSNK1A1L0.64678914
79CDK150.63449266
80PKN10.63137921
81CDK140.62465848
82AKT30.61841930
83WEE10.61716011
84IRAK10.59759905
85IRAK20.58604663
86PRKCE0.56400913
87VRK10.55706340
88CDK11A0.53756565
89MAP3K60.52745381
90STK380.51973000
91STK390.51928054
92CAMK2D0.51452035
93FES0.50420949
94WNK10.50115977
95PLK40.49633952
96CAMKK10.49525545
97PRKCH0.47609927
98BMPR20.47075695
99CAMK10.46689381
100DMPK0.45639632
101TYRO30.45601469
102ICK0.45310364
103STK110.44811251
104NLK0.44471265
105ERBB20.43503392
106MAPK100.43320634
107HIPK20.42435375
108PRKG10.41507938
109GRK50.41225693
110RPS6KA30.41216529
111PRKACA0.40830710
112BMPR1B0.40642871
113GSK3B0.40192363
114STK240.39694880
115PIK3CA0.38184208
116MKNK20.37393790
117MAP3K130.37160532
118CDK190.37069255
119CSNK1G30.36786491
120MELK0.36781793
121PRKCZ0.36619178
122FGFR10.35426095
123CSNK1A10.34316418
124FYN0.33900293
125MAPK90.33432240
126PRKACB0.32939851
127CSNK1D0.32618727
128PRKAA10.32504421
129CAMK40.32392980
130MAP3K70.32375523
131SRPK10.31763133
132CSNK1E0.31319997
133FER0.31269223
134BRSK20.31074406
135PLK30.30820671
136ACVR1B0.27360048

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.56056692
2Circadian entrainment_Homo sapiens_hsa047132.90521869
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.88483423
4Glutamatergic synapse_Homo sapiens_hsa047242.67743319
5Olfactory transduction_Homo sapiens_hsa047402.55584211
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52046366
7Morphine addiction_Homo sapiens_hsa050322.42224733
8GABAergic synapse_Homo sapiens_hsa047272.38655127
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.37808746
10Long-term potentiation_Homo sapiens_hsa047202.37735206
11Amphetamine addiction_Homo sapiens_hsa050312.25442431
12Dopaminergic synapse_Homo sapiens_hsa047282.05640881
13Insulin secretion_Homo sapiens_hsa049111.99657725
14Axon guidance_Homo sapiens_hsa043601.92397392
15Steroid biosynthesis_Homo sapiens_hsa001001.90538378
16Serotonergic synapse_Homo sapiens_hsa047261.86914746
17Phototransduction_Homo sapiens_hsa047441.85619573
18Cocaine addiction_Homo sapiens_hsa050301.80634483
19Cholinergic synapse_Homo sapiens_hsa047251.80246549
20Synaptic vesicle cycle_Homo sapiens_hsa047211.77817389
21Protein export_Homo sapiens_hsa030601.76202472
22Taste transduction_Homo sapiens_hsa047421.76093207
23Butanoate metabolism_Homo sapiens_hsa006501.62959290
24Salivary secretion_Homo sapiens_hsa049701.61298737
25Long-term depression_Homo sapiens_hsa047301.55256334
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48582156
27Type II diabetes mellitus_Homo sapiens_hsa049301.46687280
28GnRH signaling pathway_Homo sapiens_hsa049121.45585193
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45551823
30Nitrogen metabolism_Homo sapiens_hsa009101.45278360
31Propanoate metabolism_Homo sapiens_hsa006401.41874523
32Calcium signaling pathway_Homo sapiens_hsa040201.37415412
33Oxytocin signaling pathway_Homo sapiens_hsa049211.36894053
34Renin secretion_Homo sapiens_hsa049241.35308288
35ErbB signaling pathway_Homo sapiens_hsa040121.33161131
36Huntingtons disease_Homo sapiens_hsa050161.32824640
37cAMP signaling pathway_Homo sapiens_hsa040241.32101625
38Dorso-ventral axis formation_Homo sapiens_hsa043201.31582619
39Gastric acid secretion_Homo sapiens_hsa049711.28597383
40Melanogenesis_Homo sapiens_hsa049161.23713099
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.22661581
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20860809
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20820417
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20397284
45Circadian rhythm_Homo sapiens_hsa047101.20151558
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18502227
47Basal transcription factors_Homo sapiens_hsa030221.17676526
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17502141
49Chemical carcinogenesis_Homo sapiens_hsa052041.15896767
50beta-Alanine metabolism_Homo sapiens_hsa004101.13527051
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12130274
52Peroxisome_Homo sapiens_hsa041461.12123008
53Wnt signaling pathway_Homo sapiens_hsa043101.08302183
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07536419
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.05973642
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05608377
57Linoleic acid metabolism_Homo sapiens_hsa005911.03366413
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03079946
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02495412
60Regulation of autophagy_Homo sapiens_hsa041401.02371293
61Glioma_Homo sapiens_hsa052141.00733045
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00043776
63Estrogen signaling pathway_Homo sapiens_hsa049150.98837489
64Basal cell carcinoma_Homo sapiens_hsa052170.98557922
65Gap junction_Homo sapiens_hsa045400.97965497
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95806721
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95648761
68Cardiac muscle contraction_Homo sapiens_hsa042600.94089865
69Oocyte meiosis_Homo sapiens_hsa041140.93033777
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92511095
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91725151
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91578749
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90769471
74ABC transporters_Homo sapiens_hsa020100.89675118
75Histidine metabolism_Homo sapiens_hsa003400.89511220
76Notch signaling pathway_Homo sapiens_hsa043300.88347186
77Choline metabolism in cancer_Homo sapiens_hsa052310.87044210
78Ras signaling pathway_Homo sapiens_hsa040140.85782476
79Alcoholism_Homo sapiens_hsa050340.85037156
80Hedgehog signaling pathway_Homo sapiens_hsa043400.82122872
81Ovarian steroidogenesis_Homo sapiens_hsa049130.81615147
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.81543884
83Endometrial cancer_Homo sapiens_hsa052130.81199708
84MAPK signaling pathway_Homo sapiens_hsa040100.80815623
85Fanconi anemia pathway_Homo sapiens_hsa034600.80669344
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.78051108
87Colorectal cancer_Homo sapiens_hsa052100.76413462
88RNA degradation_Homo sapiens_hsa030180.75010960
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74691124
90Thyroid hormone synthesis_Homo sapiens_hsa049180.74305898
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71201380
92Caffeine metabolism_Homo sapiens_hsa002320.71121424
93Pancreatic secretion_Homo sapiens_hsa049720.69730257
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69359238
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68798108
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.67993101
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67934213
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66218894
99Retinol metabolism_Homo sapiens_hsa008300.64802512
100Oxidative phosphorylation_Homo sapiens_hsa001900.64802284
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63958886
102TGF-beta signaling pathway_Homo sapiens_hsa043500.62964678
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.62613384
104Hippo signaling pathway_Homo sapiens_hsa043900.62364140
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60748779
106Ether lipid metabolism_Homo sapiens_hsa005650.60709854
107Renal cell carcinoma_Homo sapiens_hsa052110.59310579
108Rap1 signaling pathway_Homo sapiens_hsa040150.58514211
109Dilated cardiomyopathy_Homo sapiens_hsa054140.58074911
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57324922
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57276805
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56756392
113Parkinsons disease_Homo sapiens_hsa050120.55494572
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53105696
115Fatty acid metabolism_Homo sapiens_hsa012120.52865545
116Inositol phosphate metabolism_Homo sapiens_hsa005620.52748953
117Glucagon signaling pathway_Homo sapiens_hsa049220.52256412
118Collecting duct acid secretion_Homo sapiens_hsa049660.51490114
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50589076
120Autoimmune thyroid disease_Homo sapiens_hsa053200.50325131
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48971405
122Phenylalanine metabolism_Homo sapiens_hsa003600.48892362
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48460686
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.48170685
125Vibrio cholerae infection_Homo sapiens_hsa051100.47608078
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47266313
127VEGF signaling pathway_Homo sapiens_hsa043700.47254166
128Non-homologous end-joining_Homo sapiens_hsa034500.46930096
129Tryptophan metabolism_Homo sapiens_hsa003800.46883472
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46813116
131Prolactin signaling pathway_Homo sapiens_hsa049170.44744041
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44489684
133Glycerolipid metabolism_Homo sapiens_hsa005610.44161149
134Chemokine signaling pathway_Homo sapiens_hsa040620.43155820
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42705371
136FoxO signaling pathway_Homo sapiens_hsa040680.40855776
137Adherens junction_Homo sapiens_hsa045200.40009802
138mTOR signaling pathway_Homo sapiens_hsa041500.39943934
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39388706
140Non-small cell lung cancer_Homo sapiens_hsa052230.38481331
141Prostate cancer_Homo sapiens_hsa052150.38109901
142Insulin signaling pathway_Homo sapiens_hsa049100.36015897
143MicroRNAs in cancer_Homo sapiens_hsa052060.34109395
144Type I diabetes mellitus_Homo sapiens_hsa049400.33300413
145Tight junction_Homo sapiens_hsa045300.31674221
146Fatty acid biosynthesis_Homo sapiens_hsa000610.31532495

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