RFX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)5.78005450
2innervation (GO:0060384)5.66005981
3auditory behavior (GO:0031223)5.40004424
4negative regulation of astrocyte differentiation (GO:0048712)5.11562548
5response to auditory stimulus (GO:0010996)4.73384285
6limb bud formation (GO:0060174)4.68974525
7cellular response to cholesterol (GO:0071397)4.62131562
8lung epithelium development (GO:0060428)4.52157064
9alanine transport (GO:0032328)4.49085810
10C4-dicarboxylate transport (GO:0015740)4.48472082
11L-amino acid import (GO:0043092)4.45994953
12lens fiber cell development (GO:0070307)4.39777519
13amino acid import (GO:0043090)4.39424250
14negative regulation of sodium ion transport (GO:0010766)4.34683004
15pyrimidine nucleobase catabolic process (GO:0006208)4.27551894
16cilium or flagellum-dependent cell motility (GO:0001539)4.25240717
17negative regulation of oligodendrocyte differentiation (GO:0048715)4.12626402
18startle response (GO:0001964)4.10360816
19central nervous system myelination (GO:0022010)4.08612706
20axon ensheathment in central nervous system (GO:0032291)4.08612706
21chondroitin sulfate catabolic process (GO:0030207)4.07560304
22regulation of timing of cell differentiation (GO:0048505)4.03688309
23regulation of astrocyte differentiation (GO:0048710)4.02725155
24mechanosensory behavior (GO:0007638)3.93031952
25lateral sprouting from an epithelium (GO:0060601)3.89060895
26negative regulation of cytosolic calcium ion concentration (GO:0051481)3.83804058
27* negative regulation of smoothened signaling pathway (GO:0045879)3.83005830
28glial cell proliferation (GO:0014009)3.81141574
29positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.79922741
30photoreceptor cell differentiation (GO:0046530)3.79801684
31eye photoreceptor cell differentiation (GO:0001754)3.79801684
32gamma-aminobutyric acid transport (GO:0015812)3.75541907
33cellular potassium ion homeostasis (GO:0030007)3.74148266
34regulation of development, heterochronic (GO:0040034)3.71785426
35negative regulation of glial cell differentiation (GO:0045686)3.71298756
36neuron cell-cell adhesion (GO:0007158)3.71113118
37oligodendrocyte differentiation (GO:0048709)3.66283755
38cellular response to sterol (GO:0036315)3.65815625
39tongue development (GO:0043586)3.63634194
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.61399850
41G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.57058232
42ovulation cycle (GO:0042698)3.55780732
43dermatan sulfate biosynthetic process (GO:0030208)3.54567692
44otic vesicle formation (GO:0030916)3.49930880
45cell proliferation in forebrain (GO:0021846)3.49767415
46sodium ion export (GO:0071436)3.49719661
47neurotransmitter-gated ion channel clustering (GO:0072578)3.47044851
48dermatan sulfate metabolic process (GO:0030205)3.43914131
49regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.43676339
50locomotory exploration behavior (GO:0035641)3.43139620
51cilium movement (GO:0003341)3.40933105
52astrocyte differentiation (GO:0048708)3.39473896
53neuron fate determination (GO:0048664)3.38128983
54neuronal stem cell maintenance (GO:0097150)3.36389417
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.36245302
56appendage development (GO:0048736)3.36103067
57limb development (GO:0060173)3.36103067
58neuroblast proliferation (GO:0007405)3.35889734
59epithelial cilium movement (GO:0003351)3.35490314
60L-serine transport (GO:0015825)3.34197643
61retinal ganglion cell axon guidance (GO:0031290)3.33430453
62nucleobase catabolic process (GO:0046113)3.33263629
63atrial cardiac muscle cell action potential (GO:0086014)3.29968411
64cell communication by electrical coupling (GO:0010644)3.29936721
65intraciliary transport (GO:0042073)3.29451803
66low-density lipoprotein particle remodeling (GO:0034374)3.29392887
67layer formation in cerebral cortex (GO:0021819)3.28580932
68transmission of nerve impulse (GO:0019226)3.23396481
69neurotransmitter uptake (GO:0001504)3.21839810
70nonmotile primary cilium assembly (GO:0035058)3.18652416
71establishment of planar polarity (GO:0001736)3.18426969
72establishment of tissue polarity (GO:0007164)3.18426969
73somite development (GO:0061053)3.18157418
74alpha-linolenic acid metabolic process (GO:0036109)3.17679167
75positive regulation of astrocyte differentiation (GO:0048711)3.17328823
76regulation of oligodendrocyte differentiation (GO:0048713)3.15991032
77neuron recognition (GO:0008038)3.15403074
78Sertoli cell development (GO:0060009)3.14734374
79forebrain neuron differentiation (GO:0021879)3.12987563
80thalamus development (GO:0021794)3.12349040
81ventricular system development (GO:0021591)3.11161166
82central nervous system projection neuron axonogenesis (GO:0021952)3.09853302
83regulation of somitogenesis (GO:0014807)3.09143190
84negative regulation of axon guidance (GO:1902668)3.06549349
85regulation of phospholipid biosynthetic process (GO:0071071)3.03650732
86radial glial cell differentiation (GO:0060019)3.03471817
87spinal cord development (GO:0021510)3.02415617
88axonal fasciculation (GO:0007413)3.01451835
89* midbrain development (GO:0030901)3.01196640
90cranial nerve development (GO:0021545)3.00243553
91cerebellar granule cell differentiation (GO:0021707)2.99796145
92cochlea morphogenesis (GO:0090103)2.98047517
93acrosome reaction (GO:0007340)2.96905584
94smoothened signaling pathway (GO:0007224)2.96626966
95regulation of respiratory system process (GO:0044065)2.95603545
96lung-associated mesenchyme development (GO:0060484)2.93869390
97positive regulation of oligodendrocyte differentiation (GO:0048714)2.93722515
98cilium morphogenesis (GO:0060271)2.93367338
99* cilium assembly (GO:0042384)2.91769555
100* cilium organization (GO:0044782)2.90042245
101cell morphogenesis involved in neuron differentiation (GO:0048667)2.89799264
102establishment of nucleus localization (GO:0040023)2.89236031
103dendritic spine morphogenesis (GO:0060997)2.88891175
104postsynaptic membrane organization (GO:0001941)2.87560189
105detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87014321
106negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.85775605
107positive regulation of synapse assembly (GO:0051965)2.84885509
108linoleic acid metabolic process (GO:0043651)2.84482443
109negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.81530520
110hindbrain development (GO:0030902)2.80681542
111regulation of glial cell differentiation (GO:0045685)2.79868756
112membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.78681469
113cerebral cortex radially oriented cell migration (GO:0021799)2.78490714
114regulation of inositol phosphate biosynthetic process (GO:0010919)2.78423665
115neuronal action potential propagation (GO:0019227)2.76658251
116negative regulation of transcription regulatory region DNA binding (GO:2000678)2.76350929
117cellular sodium ion homeostasis (GO:0006883)2.74911187
118ionotropic glutamate receptor signaling pathway (GO:0035235)2.74775735
119microtubule depolymerization (GO:0007019)2.72417556
120positive regulation of neuroblast proliferation (GO:0002052)2.71268684
121axonemal dynein complex assembly (GO:0070286)2.70988218
122vocalization behavior (GO:0071625)2.70855433
123midgut development (GO:0007494)2.70303117
124serine transport (GO:0032329)2.69050279
125negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.68295493
126regulation of cilium movement (GO:0003352)2.67481457
127calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.67449111
128sperm motility (GO:0030317)2.66970096
129regulation of synaptic transmission, glutamatergic (GO:0051966)2.66859358
130regulation of axon guidance (GO:1902667)2.65317089
131glomerular filtration (GO:0003094)2.65208722
132olfactory bulb development (GO:0021772)2.64845793
133adenine nucleotide transport (GO:0051503)2.64713907
134regulation of gliogenesis (GO:0014013)2.64489244
135presynaptic membrane assembly (GO:0097105)2.63932651
136protein localization to synapse (GO:0035418)2.63132731
137regulation of sister chromatid cohesion (GO:0007063)2.61417101
138inner ear receptor stereocilium organization (GO:0060122)2.60524466
139behavioral response to nicotine (GO:0035095)2.59926102
140cochlea development (GO:0090102)2.59658695
141spinal cord association neuron differentiation (GO:0021527)2.59449209
142negative regulation of axon extension (GO:0030517)2.58722354
143regulation of mesenchymal cell apoptotic process (GO:2001053)2.57724731
144axon extension involved in axon guidance (GO:0048846)2.55301755
145neuron projection extension involved in neuron projection guidance (GO:1902284)2.55301755
146central nervous system neuron axonogenesis (GO:0021955)2.52837618
147glial cell differentiation (GO:0010001)2.47586750
148negative regulation of neurotransmitter transport (GO:0051589)2.46429080
149cell differentiation in spinal cord (GO:0021515)2.46130056
150regulation of neurotransmitter uptake (GO:0051580)2.44331894
151resolution of meiotic recombination intermediates (GO:0000712)2.41936300

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.44340299
2EED_16625203_ChIP-ChIP_MESCs_Mouse2.91703794
3GBX2_23144817_ChIP-Seq_PC3_Human2.82762727
4SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.80605093
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65398897
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.63462396
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60876040
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56910293
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.50995782
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49277308
11* CBX2_27304074_Chip-Seq_ESCs_Mouse2.46206010
12AR_21572438_ChIP-Seq_LNCaP_Human2.44064342
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42925787
14* RNF2_27304074_Chip-Seq_ESCs_Mouse2.40378140
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38318790
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.36714586
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35904734
18RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.32061620
19* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30172339
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30172339
21IGF1R_20145208_ChIP-Seq_DFB_Human2.25848536
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23312343
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.18995014
24* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18780442
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08224871
26POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06413797
27* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01384377
28* REST_21632747_ChIP-Seq_MESCs_Mouse1.95079450
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93433829
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.90263544
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.90091280
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.89641344
33* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88911008
34VDR_22108803_ChIP-Seq_LS180_Human1.80306442
35EWS_26573619_Chip-Seq_HEK293_Human1.76363581
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72132008
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71714837
38DROSHA_22980978_ChIP-Seq_HELA_Human1.69749954
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.66226465
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59272527
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57810725
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57538459
43* RING1B_27294783_Chip-Seq_ESCs_Mouse1.52844971
44P300_19829295_ChIP-Seq_ESCs_Human1.52776207
45ZNF274_21170338_ChIP-Seq_K562_Hela1.47480730
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47252522
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44929433
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44881163
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42373524
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40428428
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37636245
52* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35916996
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.34720204
54ER_23166858_ChIP-Seq_MCF-7_Human1.34639112
55* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34080817
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33024234
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33024234
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.30597084
59* SMAD4_21799915_ChIP-Seq_A2780_Human1.30338583
60* REST_18959480_ChIP-ChIP_MESCs_Mouse1.28884526
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27217266
62BCAT_22108803_ChIP-Seq_LS180_Human1.25228194
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24249922
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22931854
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22401639
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22282116
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22010284
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21716602
69* TP53_20018659_ChIP-ChIP_R1E_Mouse1.21672530
70* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20864169
71* ERG_21242973_ChIP-ChIP_JURKAT_Human1.20051378
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.19916643
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18586767
74FUS_26573619_Chip-Seq_HEK293_Human1.16991181
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16551628
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16139748
77TCF4_23295773_ChIP-Seq_U87_Human1.15240191
78* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14761703
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.13758532
80AR_25329375_ChIP-Seq_VCAP_Human1.13678644
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12466816
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.12023735
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11577001
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11310766
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.11216914
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09843414
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.09660616
88AR_19668381_ChIP-Seq_PC3_Human1.09066254
89* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08337628
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08333825
91SOX9_26525672_Chip-Seq_HEART_Mouse1.08217289
92TAF15_26573619_Chip-Seq_HEK293_Human1.07694859
93WDR5_24793694_ChIP-Seq_LNCAP_Human1.07177023
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07068235
95OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05922653
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05530822
97TCF4_22108803_ChIP-Seq_LS180_Human1.05442409
98STAT3_23295773_ChIP-Seq_U87_Human1.04938117
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04547996
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04408371
101* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04084159
102WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03223286
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02801199
104* SOX2_21211035_ChIP-Seq_LN229_Gbm1.02677155
105* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00476208
106* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99358849
107* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99183037
108PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98866916
109RNF2_27304074_Chip-Seq_NSC_Mouse0.98088576
110CBP_20019798_ChIP-Seq_JUKART_Human0.95515169
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95515169
112* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95151854
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94479893
114AHR_22903824_ChIP-Seq_MCF-7_Human0.94216076
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94025324
116RUNX2_22187159_ChIP-Seq_PCA_Human0.93688576
117TAL1_26923725_Chip-Seq_HPCs_Mouse0.92931227
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92584500
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91681729
120* SMAD3_21741376_ChIP-Seq_ESCs_Human0.91648233
121TP53_18474530_ChIP-ChIP_U2OS_Human0.89279986
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88894593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.58860130
2MP0004858_abnormal_nervous_system3.26958769
3MP0000566_synostosis3.21038666
4MP0002653_abnormal_ependyma_morphology2.98250168
5MP0005423_abnormal_somatic_nervous2.76659339
6MP0000778_abnormal_nervous_system2.73666284
7MP0004859_abnormal_synaptic_plasticity2.51287817
8MP0004885_abnormal_endolymph2.47992783
9MP0005646_abnormal_pituitary_gland2.44998915
10MP0005410_abnormal_fertilization2.33665693
11MP0002736_abnormal_nociception_after2.32517306
12MP0001486_abnormal_startle_reflex2.24599073
13MP0002249_abnormal_larynx_morphology2.14772676
14MP0001502_abnormal_circadian_rhythm2.09224207
15MP0003635_abnormal_synaptic_transmissio1.98489441
16MP0003634_abnormal_glial_cell1.98102069
17MP0003690_abnormal_glial_cell1.89056179
18MP0001984_abnormal_olfaction1.88333841
19MP0001968_abnormal_touch/_nociception1.87257609
20MP0009384_cardiac_valve_regurgitation1.82294150
21MP0003880_abnormal_central_pattern1.77793295
22MP0002063_abnormal_learning/memory/cond1.75448650
23MP0002572_abnormal_emotion/affect_behav1.70518798
24MP0006072_abnormal_retinal_apoptosis1.70424960
25MP0002064_seizures1.67846987
26MP0002282_abnormal_trachea_morphology1.67166721
27MP0002254_reproductive_system_inflammat1.66721206
28MP0005248_abnormal_Harderian_gland1.66135346
29MP0003283_abnormal_digestive_organ1.63017339
30MP0000049_abnormal_middle_ear1.58804471
31MP0005377_hearing/vestibular/ear_phenot1.57856269
32MP0003878_abnormal_ear_physiology1.57856269
33MP0001485_abnormal_pinna_reflex1.57314400
34MP0002557_abnormal_social/conspecific_i1.56536558
35MP0003942_abnormal_urinary_system1.56113560
36MP0000026_abnormal_inner_ear1.54406204
37MP0009745_abnormal_behavioral_response1.51408473
38MP0002067_abnormal_sensory_capabilities1.50526625
39MP0010030_abnormal_orbit_morphology1.49170381
40MP0008789_abnormal_olfactory_epithelium1.49087490
41MP0005394_taste/olfaction_phenotype1.48264314
42MP0005499_abnormal_olfactory_system1.48264314
43MP0003329_amyloid_beta_deposits1.48259215
44MP0000955_abnormal_spinal_cord1.45721215
45MP0006276_abnormal_autonomic_nervous1.44376668
46MP0004742_abnormal_vestibular_system1.42456898
47MP0001529_abnormal_vocalization1.40220373
48MP0009046_muscle_twitch1.38974442
49MP0002735_abnormal_chemical_nociception1.38917035
50* MP0002152_abnormal_brain_morphology1.36892557
51MP0004270_analgesia1.35719197
52MP0003115_abnormal_respiratory_system1.35431804
53MP0002751_abnormal_autonomic_nervous1.30740136
54MP0000537_abnormal_urethra_morphology1.28728177
55MP0002638_abnormal_pupillary_reflex1.27702057
56MP0002822_catalepsy1.25592519
57MP0000579_abnormal_nail_morphology1.21942622
58MP0005187_abnormal_penis_morphology1.19972449
59MP0003698_abnormal_male_reproductive1.18598974
60MP0000383_abnormal_hair_follicle1.18593135
61* MP0003861_abnormal_nervous_system1.18437976
62MP0000428_abnormal_craniofacial_morphol1.18418503
63MP0006292_abnormal_olfactory_placode1.18385185
64MP0001293_anophthalmia1.18194732
65MP0002938_white_spotting1.16975495
66MP0002882_abnormal_neuron_morphology1.15955074
67MP0004142_abnormal_muscle_tone1.15107219
68MP0004133_heterotaxia1.15041945
69MP0001177_atelectasis1.12945146
70MP0000467_abnormal_esophagus_morphology1.12896953
71MP0009250_abnormal_appendicular_skeleto1.11516384
72MP0002102_abnormal_ear_morphology1.10970418
73MP0009379_abnormal_foot_pigmentation1.10824112
74MP0009780_abnormal_chondrocyte_physiolo1.10606767
75MP0001440_abnormal_grooming_behavior1.10139680
76MP0005195_abnormal_posterior_eye1.09339282
77MP0000647_abnormal_sebaceous_gland1.08483588
78MP0005171_absent_coat_pigmentation1.08377635
79* MP0000631_abnormal_neuroendocrine_gland1.07144747
80MP0002116_abnormal_craniofacial_bone1.06624094
81MP0008961_abnormal_basal_metabolism1.06255979
82MP0003938_abnormal_ear_development1.06223094
83MP0002095_abnormal_skin_pigmentation1.06083773
84MP0002184_abnormal_innervation1.05642566
85MP0005551_abnormal_eye_electrophysiolog1.04522912
86MP0002733_abnormal_thermal_nociception1.02675304
87MP0003632_abnormal_nervous_system1.02483939
88MP0009053_abnormal_anal_canal1.01955929
89MP0003937_abnormal_limbs/digits/tail_de1.00596457
90MP0001299_abnormal_eye_distance/1.00562816
91MP0003119_abnormal_digestive_system1.00486067
92MP0001286_abnormal_eye_development1.00266380
93MP0005253_abnormal_eye_physiology1.00156191
94MP0001501_abnormal_sleep_pattern0.99852289
95MP0001970_abnormal_pain_threshold0.99424819
96MP0003122_maternal_imprinting0.98578494
97MP0002272_abnormal_nervous_system0.97364422
98MP0002697_abnormal_eye_size0.95057517
99MP0003121_genomic_imprinting0.94512181
100MP0005167_abnormal_blood-brain_barrier0.93018225
101MP0003755_abnormal_palate_morphology0.92867633
102MP0001346_abnormal_lacrimal_gland0.92752363
103MP0002089_abnormal_postnatal_growth/wei0.92704695
104MP0001905_abnormal_dopamine_level0.91673835
105MP0003137_abnormal_impulse_conducting0.90695339
106MP0000534_abnormal_ureter_morphology0.90451203
107MP0002752_abnormal_somatic_nervous0.89906472
108MP0002066_abnormal_motor_capabilities/c0.89647649
109MP0001963_abnormal_hearing_physiology0.89411255
110MP0003011_delayed_dark_adaptation0.89379598
111MP0002233_abnormal_nose_morphology0.88394705
112MP0005391_vision/eye_phenotype0.86542969
113MP0005623_abnormal_meninges_morphology0.84851194
114MP0003315_abnormal_perineum_morphology0.84688733
115MP0005174_abnormal_tail_pigmentation0.84475209
116MP0005379_endocrine/exocrine_gland_phen0.82974343
117MP0003183_abnormal_peptide_metabolism0.79940240
118MP0008569_lethality_at_weaning0.79236385
119MP0003890_abnormal_embryonic-extraembry0.78224696
120MP0002734_abnormal_mechanical_nocicepti0.77529034
121MP0002092_abnormal_eye_morphology0.77035734
122MP0002234_abnormal_pharynx_morphology0.76988410
123MP0004924_abnormal_behavior0.76520887
124MP0005386_behavior/neurological_phenoty0.76520887
125MP0000569_abnormal_digit_pigmentation0.76312466

Predicted human phenotypes

RankGene SetZ-score
1Megalencephaly (HP:0001355)5.04578997
2Oligodactyly (hands) (HP:0001180)4.78257224
3Aplasia involving bones of the extremities (HP:0009825)4.50626764
4Aplasia involving bones of the upper limbs (HP:0009823)4.50626764
5Aplasia of the phalanges of the hand (HP:0009802)4.50626764
6Oligodactyly (HP:0012165)3.82808734
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.78381337
8Absent/shortened dynein arms (HP:0200106)3.78381337
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.62941404
10Focal motor seizures (HP:0011153)3.55288034
11Synostosis involving the elbow (HP:0003938)3.54526748
12Humeroradial synostosis (HP:0003041)3.54526748
13Maternal diabetes (HP:0009800)3.48137444
14Split foot (HP:0001839)3.32289883
15Pancreatic cysts (HP:0001737)3.29870928
16Hemiparesis (HP:0001269)3.21910619
17Abnormal respiratory motile cilium physiology (HP:0012261)3.16649416
18Adactyly (HP:0009776)3.03470408
19Abnormal ciliary motility (HP:0012262)2.97643041
20Septo-optic dysplasia (HP:0100842)2.97568724
21Abnormal respiratory epithelium morphology (HP:0012253)2.94995843
22Abnormal respiratory motile cilium morphology (HP:0005938)2.94995843
23Abnormality of midbrain morphology (HP:0002418)2.93494370
24Molar tooth sign on MRI (HP:0002419)2.93494370
25Pseudobulbar signs (HP:0002200)2.89824716
26Type II lissencephaly (HP:0007260)2.83538862
27Fibular aplasia (HP:0002990)2.82969826
28Esophageal atresia (HP:0002032)2.81389487
29Retinal dysplasia (HP:0007973)2.77089652
30Neurofibrillary tangles (HP:0002185)2.72805299
31Abnormality of the axillary hair (HP:0100134)2.68080899
32Abnormality of secondary sexual hair (HP:0009888)2.68080899
33Aplasia/Hypoplasia of the fibula (HP:0006492)2.67909593
34Gastrointestinal atresia (HP:0002589)2.63366177
35Abnormality of the renal medulla (HP:0100957)2.61507933
36Medial flaring of the eyebrow (HP:0010747)2.60040251
37True hermaphroditism (HP:0010459)2.59868951
38Hemiplegia (HP:0002301)2.58093294
39Diplopia (HP:0000651)2.57725492
40Abnormality of binocular vision (HP:0011514)2.57725492
41Abnormality of the diencephalon (HP:0010662)2.55811582
42Abnormality of the labia minora (HP:0012880)2.55414562
43Atonic seizures (HP:0010819)2.50635476
44Anophthalmia (HP:0000528)2.48712259
45Cerebellar dysplasia (HP:0007033)2.48172223
46Intestinal atresia (HP:0011100)2.47279719
47Clumsiness (HP:0002312)2.45170130
48Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.41753680
49Cystic liver disease (HP:0006706)2.37354214
50Chronic hepatic failure (HP:0100626)2.35868533
51Genital tract atresia (HP:0001827)2.34870524
52Bile duct proliferation (HP:0001408)2.34484028
53Abnormal biliary tract physiology (HP:0012439)2.34484028
54Hypoplastic pelvis (HP:0008839)2.31224040
55Focal seizures (HP:0007359)2.28751451
56Vaginal atresia (HP:0000148)2.26179607
57Bifid tongue (HP:0010297)2.25107113
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.22357715
59Increased nuchal translucency (HP:0010880)2.20724557
60Skull defect (HP:0001362)2.15997869
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15847663
62Short 4th metacarpal (HP:0010044)2.15847663
63Coronal craniosynostosis (HP:0004440)2.15331340
64Mixed hearing impairment (HP:0000410)2.12688443
65Rhinitis (HP:0012384)2.12614204
66Morphological abnormality of the middle ear (HP:0008609)2.12321597
67Renal hypoplasia (HP:0000089)2.08554250
68Cutaneous finger syndactyly (HP:0010554)2.07856829
69Preaxial foot polydactyly (HP:0001841)2.06145711
70Nephrogenic diabetes insipidus (HP:0009806)2.05592821
71Hypoplastic left heart (HP:0004383)2.05592329
72Abnormality of the 4th metacarpal (HP:0010012)2.04786523
73Fibular hypoplasia (HP:0003038)2.04758723
74Morphological abnormality of the inner ear (HP:0011390)2.04566540
75Increased corneal curvature (HP:0100692)2.03513393
76Keratoconus (HP:0000563)2.03513393
77Prenatal maternal abnormality (HP:0002686)2.02791169
78Narrow nasal bridge (HP:0000446)2.02746807
79Progressive cerebellar ataxia (HP:0002073)2.02471023
80Male pseudohermaphroditism (HP:0000037)2.02031157
81Absent hair (HP:0002298)2.00250260
82Rib fusion (HP:0000902)2.00057306
83Abnormality of the middle phalanges of the toes (HP:0010183)1.98033227
84Polyphagia (HP:0002591)1.97668632
85Aplasia involving forearm bones (HP:0009822)1.96505234
86Absent forearm bone (HP:0003953)1.96505234
87Occipital encephalocele (HP:0002085)1.95221507
88Neonatal short-limb short stature (HP:0008921)1.92844579
89Short middle phalanx of the 5th finger (HP:0004220)1.92232638
90Absent septum pellucidum (HP:0001331)1.91744282
91Cerebral inclusion bodies (HP:0100314)1.91659574
92Hypoplastic nipples (HP:0002557)1.91458904
93Sclerocornea (HP:0000647)1.91305705
94Concave nail (HP:0001598)1.90551433
95Back pain (HP:0003418)1.90434851
96Congenital hepatic fibrosis (HP:0002612)1.89354572
97Alacrima (HP:0000522)1.88531180
98Pendular nystagmus (HP:0012043)1.88436533
99Bilateral microphthalmos (HP:0007633)1.87898750
100Aplasia/Hypoplasia of the sternum (HP:0006714)1.87829091
101Aplasia/Hypoplasia of the tibia (HP:0005772)1.87719391
102Vitreoretinal degeneration (HP:0000655)1.87423211
103Synostosis of carpal bones (HP:0005048)1.87399688
104Anencephaly (HP:0002323)1.87340682
105Specific learning disability (HP:0001328)1.87065669
106Renal dysplasia (HP:0000110)1.86199628
107Aqueductal stenosis (HP:0002410)1.86031577
108Optic nerve hypoplasia (HP:0000609)1.85983090
109Absent speech (HP:0001344)1.85969885
110Hemivertebrae (HP:0002937)1.85816920
111Sex reversal (HP:0012245)1.85661021
112Abnormal sex determination (HP:0012244)1.85661021
113Bronchomalacia (HP:0002780)1.85547497
114Abnormality of the dental pulp (HP:0006479)1.84598459
115Febrile seizures (HP:0002373)1.83531727
116Pancreatic fibrosis (HP:0100732)1.82804763
117Bifid scrotum (HP:0000048)1.81990721
118Nephronophthisis (HP:0000090)1.81960404
119Hepatoblastoma (HP:0002884)1.81490405
120Abnormality of nail color (HP:0100643)1.77989501
121Poor coordination (HP:0002370)1.77987935
122Synostosis involving bones of the feet (HP:0009140)1.77613227
123Synostosis involving bones of the lower limbs (HP:0009138)1.77613227
124Preaxial hand polydactyly (HP:0001177)1.77093023
125Tarsal synostosis (HP:0008368)1.76660609
126Myelomeningocele (HP:0002475)1.76260248
127Broad alveolar ridges (HP:0000187)1.76115186
128Broad foot (HP:0001769)1.75815790
129Postaxial foot polydactyly (HP:0001830)1.75795684
130Abnormality of chromosome segregation (HP:0002916)1.75705544
131Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.75685287
132Abnormality of the septum pellucidum (HP:0007375)1.74251222
133Decreased lacrimation (HP:0000633)1.73356570
134Short tibia (HP:0005736)1.72555985
135Holoprosencephaly (HP:0001360)1.72515976
136Epileptic encephalopathy (HP:0200134)1.72087405
137Dialeptic seizures (HP:0011146)1.71238829
138Facial hemangioma (HP:0000329)1.70906805
139Midline defect of the nose (HP:0004122)1.70504950
140Narrow forehead (HP:0000341)1.70386726
141Volvulus (HP:0002580)1.69970013
142Postaxial hand polydactyly (HP:0001162)1.69446073
143Drooling (HP:0002307)1.69427596
144Cutaneous syndactyly (HP:0012725)1.68837775
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.68738185
146Gait imbalance (HP:0002141)1.67552982
147Overriding aorta (HP:0002623)1.67447758
148Hypoplastic toenails (HP:0001800)1.66553361
149Dental crowding (HP:0000678)1.65839990
150Congenital primary aphakia (HP:0007707)1.65163986
151Supernumerary spleens (HP:0009799)1.64460696
152Large earlobe (HP:0009748)1.64249595
153Absent toe (HP:0010760)1.62955008
154Partial duplication of thumb phalanx (HP:0009944)1.62821071
155Hyperventilation (HP:0002883)1.62133614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK25.48271708
2CASK3.96477911
3KSR13.15813655
4TNIK3.15484692
5SIK12.95401233
6EPHA42.65975397
7PHKG22.59263002
8PHKG12.59263002
9LMTK22.56770487
10MAPK152.40766043
11PRKD32.39580761
12WNK32.25699863
13SIK32.24108264
14NTRK12.17232591
15TRIB32.15171285
16WEE12.09682463
17PDK32.06243867
18PDK42.06243867
19MARK12.03824290
20ADRBK21.82767974
21DYRK21.80667691
22EPHB21.74565537
23ERBB21.68534611
24NEK11.65813808
25MUSK1.64452523
26FRK1.59435031
27TYRO31.57579092
28MAPK131.48054408
29BMPR1B1.47864298
30PLK21.46496620
31ICK1.46478034
32STK391.41130937
33MINK11.31093464
34GRK11.23571360
35MAP4K21.21182372
36ERBB41.15443648
37PAK61.15348298
38IRAK11.14424242
39MKNK11.12694115
40MAP3K41.09735724
41SGK21.09332309
42NTRK31.08385478
43IRAK21.04145547
44NEK61.04110367
45STK38L1.03192397
46BCR1.02566247
47BRSK11.00409249
48FGFR21.00012657
49SGK2230.98751982
50SGK4940.98751982
51PBK0.98726825
52CAMK1G0.98574281
53ZAK0.97943004
54UHMK10.97305253
55PLK40.96544283
56VRK10.96432942
57PAK30.91894629
58PDGFRA0.91202365
59PDK20.89444322
60STK380.87561579
61MARK30.87114256
62TGFBR10.82841182
63WNK40.81811753
64INSRR0.81525367
65ERBB30.78024833
66PRKCG0.76197861
67CDK180.75509735
68STK160.75462151
69CDK50.75063001
70PNCK0.75021740
71PLK30.74683068
72CDC42BPA0.73901406
73DYRK30.73296758
74CSNK1A1L0.72858224
75DYRK1B0.71023515
76SGK30.70906598
77AKT20.69797640
78MAP2K70.68049489
79EPHB10.66980870
80TSSK60.66894347
81NUAK10.66851201
82ROCK10.65735789
83ADRBK10.65650603
84CSNK1G20.65313509
85FGR0.63135382
86CDK150.62863502
87ROCK20.62217341
88MKNK20.59548750
89NEK90.59391060
90CAMK1D0.57577307
91DYRK1A0.57526068
92CDK30.57286709
93RPS6KA50.56924537
94BRSK20.56474226
95PTK60.54743390
96PRKAA10.53184327
97CDK80.52445302
98LATS10.52429795
99CDK11A0.50613390
100CSNK1G30.50389994
101BUB10.49999870
102NEK20.49907687
103CDK140.49828825
104CAMK2B0.49451139
105CAMK2A0.48399004
106PKN10.48283270
107FGFR10.47546931
108YES10.46302144
109TESK10.46175752
110SRPK10.44606128
111PRKG10.43094259
112CAMK2G0.43068216
113TLK10.42489298
114PAK40.42086259
115BRD40.41788179
116FER0.41181135
117PASK0.40855988
118SRC0.40221221
119OXSR10.39833385
120CAMKK10.39813490
121BCKDK0.39048931
122IGF1R0.37554040
123MELK0.36145760
124CSNK1A10.36105902
125PRKACG0.35589759
126PLK10.34781306
127BMX0.34227672
128PRKAA20.33990128
129ATM0.33684642
130PINK10.33333485
131CSNK1G10.32879308
132CAMK2D0.32716189
133MOS0.32588958
134RPS6KA30.32428990
135PRKCZ0.31868986
136CSNK1D0.31781573
137PRKCE0.31758526
138CCNB10.31707225
139EPHA30.31488783
140STK110.31449021
141MAP2K40.30716114
142MAPK120.30317685
143TTK0.28971104

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009106.59466638
2Fatty acid biosynthesis_Homo sapiens_hsa000613.81257068
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.41793333
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.13395727
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.12973232
6Basal cell carcinoma_Homo sapiens_hsa052172.54003799
7Fatty acid metabolism_Homo sapiens_hsa012122.51609041
8Nicotine addiction_Homo sapiens_hsa050332.10370791
9Hedgehog signaling pathway_Homo sapiens_hsa043401.94497063
10Steroid biosynthesis_Homo sapiens_hsa001001.85834625
11Fatty acid degradation_Homo sapiens_hsa000711.81014659
12Phototransduction_Homo sapiens_hsa047441.68881648
13Propanoate metabolism_Homo sapiens_hsa006401.66796381
14Dorso-ventral axis formation_Homo sapiens_hsa043201.63759913
15Fanconi anemia pathway_Homo sapiens_hsa034601.59781385
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.55256895
17Glutamatergic synapse_Homo sapiens_hsa047241.52120288
18PPAR signaling pathway_Homo sapiens_hsa033201.50070222
19GABAergic synapse_Homo sapiens_hsa047271.49185237
20Protein export_Homo sapiens_hsa030601.48150655
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46630078
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36656912
23Melanogenesis_Homo sapiens_hsa049161.34690647
24Axon guidance_Homo sapiens_hsa043601.34314748
25Circadian entrainment_Homo sapiens_hsa047131.30353238
26Arginine biosynthesis_Homo sapiens_hsa002201.28133775
27Insulin secretion_Homo sapiens_hsa049111.27392712
28Bile secretion_Homo sapiens_hsa049761.26131791
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22638355
30Butanoate metabolism_Homo sapiens_hsa006501.14021629
31Basal transcription factors_Homo sapiens_hsa030221.12976521
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12069524
33Oxidative phosphorylation_Homo sapiens_hsa001901.11980573
34Fatty acid elongation_Homo sapiens_hsa000621.09834095
35Parkinsons disease_Homo sapiens_hsa050121.08791639
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06617851
37Hippo signaling pathway_Homo sapiens_hsa043901.05972141
38Salivary secretion_Homo sapiens_hsa049701.05802155
39Vitamin B6 metabolism_Homo sapiens_hsa007501.04502561
40Gastric acid secretion_Homo sapiens_hsa049711.04458499
41beta-Alanine metabolism_Homo sapiens_hsa004101.02959511
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02787081
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02278493
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02261707
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02037587
46Morphine addiction_Homo sapiens_hsa050321.01243393
47Cardiac muscle contraction_Homo sapiens_hsa042600.99782912
48Wnt signaling pathway_Homo sapiens_hsa043100.98889514
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98887942
50Notch signaling pathway_Homo sapiens_hsa043300.97129220
51Huntingtons disease_Homo sapiens_hsa050160.93085749
52Olfactory transduction_Homo sapiens_hsa047400.93042423
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91353741
54Gap junction_Homo sapiens_hsa045400.91038065
55Homologous recombination_Homo sapiens_hsa034400.90455411
56Renin secretion_Homo sapiens_hsa049240.90202233
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89873584
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86125779
59Biosynthesis of amino acids_Homo sapiens_hsa012300.82779319
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81264040
61Calcium signaling pathway_Homo sapiens_hsa040200.81257299
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81104802
63Long-term potentiation_Homo sapiens_hsa047200.80419897
64Histidine metabolism_Homo sapiens_hsa003400.79354221
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78058851
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.77764236
67Glioma_Homo sapiens_hsa052140.75496470
68Cocaine addiction_Homo sapiens_hsa050300.75033375
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72301617
70Alcoholism_Homo sapiens_hsa050340.72296795
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71658823
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71561308
73Linoleic acid metabolism_Homo sapiens_hsa005910.71245577
74cAMP signaling pathway_Homo sapiens_hsa040240.70396389
75Circadian rhythm_Homo sapiens_hsa047100.70318342
76Amphetamine addiction_Homo sapiens_hsa050310.69487364
77Mineral absorption_Homo sapiens_hsa049780.69248519
78Peroxisome_Homo sapiens_hsa041460.69204846
79Pyruvate metabolism_Homo sapiens_hsa006200.68093397
80Lysine degradation_Homo sapiens_hsa003100.67574876
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66059519
82Glucagon signaling pathway_Homo sapiens_hsa049220.64692352
83Alzheimers disease_Homo sapiens_hsa050100.64508892
84Carbon metabolism_Homo sapiens_hsa012000.63987613
85Oocyte meiosis_Homo sapiens_hsa041140.63400088
86TGF-beta signaling pathway_Homo sapiens_hsa043500.63160915
87Arginine and proline metabolism_Homo sapiens_hsa003300.62070480
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61568958
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.61528234
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61107204
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60168592
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58301545
93Sulfur metabolism_Homo sapiens_hsa009200.56790092
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.55403606
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55267480
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54794449
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53307936
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.51152867
99Taste transduction_Homo sapiens_hsa047420.50861109
100ErbB signaling pathway_Homo sapiens_hsa040120.50467103
101Estrogen signaling pathway_Homo sapiens_hsa049150.50183219
102MicroRNAs in cancer_Homo sapiens_hsa052060.49262867
103Ether lipid metabolism_Homo sapiens_hsa005650.46538257
104Long-term depression_Homo sapiens_hsa047300.45641800
105Oxytocin signaling pathway_Homo sapiens_hsa049210.45428467
106Glycerolipid metabolism_Homo sapiens_hsa005610.45357125
107Endometrial cancer_Homo sapiens_hsa052130.44140994
108Thyroid hormone synthesis_Homo sapiens_hsa049180.44121926
109Dopaminergic synapse_Homo sapiens_hsa047280.43903435
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42947826
111RNA degradation_Homo sapiens_hsa030180.42434763
112RNA polymerase_Homo sapiens_hsa030200.41838036
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.41155013
114Spliceosome_Homo sapiens_hsa030400.40706931
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40705691
116ABC transporters_Homo sapiens_hsa020100.39003738
117Pancreatic secretion_Homo sapiens_hsa049720.38624326
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38562060
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.38235062
120Serotonergic synapse_Homo sapiens_hsa047260.37920418
121Caffeine metabolism_Homo sapiens_hsa002320.37735235
122Cholinergic synapse_Homo sapiens_hsa047250.35748163
123Choline metabolism in cancer_Homo sapiens_hsa052310.34802079
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34551273
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33497788
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.32348687
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32178794
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31141573
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30966822
130Tryptophan metabolism_Homo sapiens_hsa003800.30846699
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30708038

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