RFX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)6.60742121
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.33108411
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.00963320
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.00963320
5positive regulation of gamma-delta T cell activation (GO:0046645)5.70416967
6NIK/NF-kappaB signaling (GO:0038061)4.80979535
7regulation of gamma-delta T cell differentiation (GO:0045586)4.73925664
8regulation of interleukin-12 biosynthetic process (GO:0045075)4.61220874
9positive regulation of B cell differentiation (GO:0045579)4.52753843
10B cell receptor signaling pathway (GO:0050853)4.51065971
11regulation of gamma-delta T cell activation (GO:0046643)4.22371174
12CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.03147014
13nuclear pore complex assembly (GO:0051292)3.97807644
14response to interleukin-15 (GO:0070672)3.95353774
15regulation of B cell differentiation (GO:0045577)3.91585792
16regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.87633021
17antigen processing and presentation via MHC class Ib (GO:0002475)3.85100909
18JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.78170709
19positive regulation of natural killer cell differentiation (GO:0032825)3.66012512
20regulation of B cell receptor signaling pathway (GO:0050855)3.62469480
21positive thymic T cell selection (GO:0045059)3.59638309
22negative thymic T cell selection (GO:0045060)3.51421450
23T cell lineage commitment (GO:0002360)3.50605056
24positive regulation of histone deacetylation (GO:0031065)3.49286185
25negative regulation of erythrocyte differentiation (GO:0045647)3.43263505
26hepatocyte apoptotic process (GO:0097284)3.43129145
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.39177220
28negative regulation of cell killing (GO:0031342)3.39177220
29natural killer cell differentiation (GO:0001779)3.38220003
30megakaryocyte development (GO:0035855)3.35274234
31negative T cell selection (GO:0043383)3.34463215
32B cell mediated immunity (GO:0019724)3.33583879
33growth hormone receptor signaling pathway (GO:0060396)3.31374739
34germinal center formation (GO:0002467)3.25509056
35response to peptidoglycan (GO:0032494)3.25140050
36nuclear pore organization (GO:0006999)3.23294492
37cellular response to interleukin-15 (GO:0071350)3.21780489
38positive regulation by symbiont of host defense response (GO:0052509)3.19850984
39modulation by symbiont of host defense response (GO:0052031)3.19850984
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.19850984
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.19850984
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.19850984
43modulation by symbiont of host immune response (GO:0052553)3.19850984
44thymic T cell selection (GO:0045061)3.12119615
45response to type I interferon (GO:0034340)3.11686424
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08025589
47interferon-gamma-mediated signaling pathway (GO:0060333)3.06155592
48mature B cell differentiation (GO:0002335)3.04689372
49positive regulation of interferon-alpha production (GO:0032727)3.04093589
50type I interferon signaling pathway (GO:0060337)3.04010226
51cellular response to type I interferon (GO:0071357)3.04010226
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.03433706
53T cell selection (GO:0045058)3.01719842
54pore complex assembly (GO:0046931)3.01543044
55T cell proliferation (GO:0042098)3.00610791
56DNA unwinding involved in DNA replication (GO:0006268)2.98643004
57myeloid dendritic cell differentiation (GO:0043011)2.98104110
583-UTR-mediated mRNA stabilization (GO:0070935)2.97242598
59regulation of chromatin binding (GO:0035561)2.96149464
60lymph node development (GO:0048535)2.94607109
61Peyers patch development (GO:0048541)2.94382533
62mucosal-associated lymphoid tissue development (GO:0048537)2.94382533
63T cell migration (GO:0072678)2.93871842
64detection of bacterium (GO:0016045)2.92891028
65regulation of interferon-alpha production (GO:0032647)2.89512872
66regulation of antigen processing and presentation (GO:0002577)2.89236693
67regulation of histone H3-K27 methylation (GO:0061085)2.89166928
68embryonic hemopoiesis (GO:0035162)2.88997213
69immunoglobulin mediated immune response (GO:0016064)2.87372579
70cellular response to growth hormone stimulus (GO:0071378)2.87330088
71response to muramyl dipeptide (GO:0032495)2.85853197
72myeloid dendritic cell activation (GO:0001773)2.85549788
73B cell proliferation (GO:0042100)2.85461607
74T cell homeostasis (GO:0043029)2.82166696
75detection of other organism (GO:0098543)2.80329664
76regulation of interferon-beta biosynthetic process (GO:0045357)2.80106275
77defense response to protozoan (GO:0042832)2.79118609
78lymphocyte homeostasis (GO:0002260)2.76393771
79regulation of T-helper 1 cell differentiation (GO:0045625)2.75996124
80histone H3-K36 demethylation (GO:0070544)2.72740010
81regulation of alpha-beta T cell proliferation (GO:0046640)2.72126911
82positive regulation of Rap GTPase activity (GO:0032854)2.71298812
83B cell homeostasis (GO:0001782)2.70062459
84response to protozoan (GO:0001562)2.67384591
85positive regulation of Cdc42 GTPase activity (GO:0043089)2.66711938
86spliceosomal tri-snRNP complex assembly (GO:0000244)2.65564762
87DNA topological change (GO:0006265)2.65227163
88chaperone mediated protein folding requiring cofactor (GO:0051085)2.65058175
89activated T cell proliferation (GO:0050798)2.64199827
90regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.62377696
91dosage compensation (GO:0007549)2.62310802
92regulation of interleukin-2 biosynthetic process (GO:0045076)2.62118003
93regulation of regulatory T cell differentiation (GO:0045589)2.62020531
94regulation of dendritic cell antigen processing and presentation (GO:0002604)2.61200128
95positive regulation of interleukin-12 production (GO:0032735)2.61084520
96positive T cell selection (GO:0043368)2.60459078
97dendritic cell chemotaxis (GO:0002407)2.60162613
98regulation of B cell proliferation (GO:0030888)2.60152663
99formation of translation preinitiation complex (GO:0001731)2.59274645
100mitotic chromosome condensation (GO:0007076)2.59141531
101positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.59061481
102pinocytosis (GO:0006907)2.58857306
103DNA duplex unwinding (GO:0032508)2.58573467
104snRNA metabolic process (GO:0016073)2.58394091
105antigen receptor-mediated signaling pathway (GO:0050851)2.58141452
106positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.57965840
107cytoplasmic mRNA processing body assembly (GO:0033962)2.57691995
108cellular response to interleukin-4 (GO:0071353)2.56831338
109regulation of translational fidelity (GO:0006450)2.56649468
110negative regulation of B cell proliferation (GO:0030889)2.56598672
111dendritic cell differentiation (GO:0097028)2.56568184
112regulation of natural killer cell differentiation (GO:0032823)2.56352062
113cellular hyperosmotic response (GO:0071474)2.55572713
114JAK-STAT cascade (GO:0007259)2.54032931
115histone H3-K4 trimethylation (GO:0080182)2.53899694
116lymphocyte proliferation (GO:0046651)2.53497028
117mononuclear cell proliferation (GO:0032943)2.53157870
118cellular response to interferon-beta (GO:0035458)2.52724291
119regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.51031652
120regulation of natural killer cell mediated immunity (GO:0002715)2.51031652
121regulation of erythrocyte differentiation (GO:0045646)2.49351215
122ribosomal small subunit biogenesis (GO:0042274)2.49239715
123regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.49172649
124positive regulation of antigen processing and presentation (GO:0002579)2.48552151
125definitive hemopoiesis (GO:0060216)2.48304408
126negative regulation of histone methylation (GO:0031061)2.48186954
127DNA geometric change (GO:0032392)2.48075450
128positive regulation of natural killer cell mediated immunity (GO:0002717)2.47964955
129positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.47964955
130positive regulation of alpha-beta T cell proliferation (GO:0046641)2.47914911
131positive regulation of interleukin-2 production (GO:0032743)2.47829328
132cellular response to interferon-gamma (GO:0071346)2.47506203
133positive regulation of interferon-beta production (GO:0032728)2.46778208
134T cell costimulation (GO:0031295)2.46776082
135regulation of necroptotic process (GO:0060544)2.45463344
136positive regulation of B cell activation (GO:0050871)2.43741399
137leukocyte homeostasis (GO:0001776)2.43131075
138lymphocyte costimulation (GO:0031294)2.42524713
139snRNA processing (GO:0016180)2.42168967
140regulation of type I interferon-mediated signaling pathway (GO:0060338)2.40356459
141positive regulation of natural killer cell activation (GO:0032816)2.39567216
142positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.39349200
143leukocyte proliferation (GO:0070661)2.38605052
144response to interferon-beta (GO:0035456)2.35926601
145positive regulation of alpha-beta T cell differentiation (GO:0046638)2.35203210
146RNA stabilization (GO:0043489)2.30723451
147mRNA stabilization (GO:0048255)2.30723451

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.28790713
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.27525510
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.59273048
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.58756026
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.95358181
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.40769117
7SCL_19346495_ChIP-Seq_HPC-7_Human3.30707665
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14635433
9MYC_22102868_ChIP-Seq_BL_Human3.13083318
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02119887
11RUNX_20019798_ChIP-Seq_JUKART_Human3.01551225
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99087411
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.94311144
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.82512519
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.78237153
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.78095663
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65356455
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.61660358
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57402688
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48896434
21* TCF7_22412390_ChIP-Seq_EML_Mouse2.46720623
22VDR_21846776_ChIP-Seq_THP-1_Human2.40935259
23GATA1_22025678_ChIP-Seq_K562_Human2.36317183
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32493686
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.27862636
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.27796002
27* MAF_26560356_Chip-Seq_TH1_Human2.20790215
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19797048
29* MYB_26560356_Chip-Seq_TH2_Human2.17127891
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.12886336
31* MYB_26560356_Chip-Seq_TH1_Human2.12599169
32* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12005263
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.08015973
34SMAD_19615063_ChIP-ChIP_OVARY_Human2.05973108
35VDR_24763502_ChIP-Seq_THP-1_Human2.02348253
36* UTX_26944678_Chip-Seq_JUKART_Human1.86070789
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86052615
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.85420369
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84789693
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83079201
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82301035
42SPI1_23127762_ChIP-Seq_K562_Human1.78752284
43* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76568850
44KDM2B_26808549_Chip-Seq_DND41_Human1.75455383
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70816847
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69843255
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66670584
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65477770
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65009496
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64737899
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62255771
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60769341
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58384698
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54132089
55XRN2_22483619_ChIP-Seq_HELA_Human1.53854971
56* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52518892
57GATA3_27048872_Chip-Seq_THYMUS_Human1.52272422
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.51136456
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49332350
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48782402
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44867223
62KDM5A_27292631_Chip-Seq_BREAST_Human1.43303559
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41544544
64* RUNX1_22412390_ChIP-Seq_EML_Mouse1.41186093
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41074734
66* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40183923
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.37986452
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36938684
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36290404
70SPI1_23547873_ChIP-Seq_NB4_Human1.35986831
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35151433
72TFEB_21752829_ChIP-Seq_HELA_Human1.33630020
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31972834
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30387539
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28868182
76FOXP3_21729870_ChIP-Seq_TREG_Human1.28526101
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.27919977
78PU_27001747_Chip-Seq_BMDM_Mouse1.27060071
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26509471
80* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25082023
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.24095729
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23303252
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22116327
84JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16601107
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15638731
86VDR_24787735_ChIP-Seq_THP-1_Human1.14762511
87MAF_26560356_Chip-Seq_TH2_Human1.14388767
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14269283
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.13178681
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.12869537
91* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12678143
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11320008
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11047230
94GATA3_26560356_Chip-Seq_TH2_Human1.10889724
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09830664
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07190760
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07174395
98DCP1A_22483619_ChIP-Seq_HELA_Human1.04830189
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03399937
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01442187
101VDR_23849224_ChIP-Seq_CD4+_Human1.01211055
102GABP_19822575_ChIP-Seq_HepG2_Human1.00967970
103* ELK3_25401928_ChIP-Seq_HUVEC_Human1.00759129
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00579069
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00239613
106ZNF263_19887448_ChIP-Seq_K562_Human0.99963719
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98476005
108TTF2_22483619_ChIP-Seq_HELA_Human0.97892781
109RACK7_27058665_Chip-Seq_MCF-7_Human0.97139948
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.96995791
111STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96979274
112ETS1_20019798_ChIP-Seq_JURKAT_Human0.96832431
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95786216
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95717548
115GATA1_19941826_ChIP-Seq_K562_Human0.95415283
116NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95247492
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94840204
118THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93319683
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92627371
120GATA2_19941826_ChIP-Seq_K562_Human0.91333598
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91154674
122FOXM1_23109430_ChIP-Seq_U2OS_Human0.90580788
123* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89736920
124* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87487986
125* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85898917
126MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85088165
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83486485
128NCOR1_26117541_ChIP-Seq_K562_Human0.83116881
129* CIITA_25753668_ChIP-Seq_RAJI_Human0.83002033
130PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82519626
131SMRT_27268052_Chip-Seq_Bcells_Human0.81887388
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81885662
133CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77838068
134PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77258872
135GATA3_26560356_Chip-Seq_TH1_Human0.76169489
136* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74931964
137TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74645011
138* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.72512210
139FOXA2_19822575_ChIP-Seq_HepG2_Human0.70943744
140RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.70166599
141GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69596474
142LXR_22292898_ChIP-Seq_THP-1_Human0.67297257
143TP53_16413492_ChIP-PET_HCT116_Human0.67290773
144SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.65989526
145CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.62982213
146RUNX1_27514584_Chip-Seq_MCF-7_Human0.62581145

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.28814132
2MP0000685_abnormal_immune_system3.72460069
3* MP0001800_abnormal_humoral_immune3.42361393
4MP0001790_abnormal_immune_system3.34815357
5MP0005387_immune_system_phenotype3.34815357
6MP0002254_reproductive_system_inflammat3.27482559
7MP0004510_myositis3.21548338
8MP0005671_abnormal_response_to2.90749732
9MP0008057_abnormal_DNA_replication2.84622428
10* MP0002452_abnormal_antigen_presenting2.72536482
11MP0001873_stomach_inflammation2.65282036
12MP0005000_abnormal_immune_tolerance2.65046333
13MP0003300_gastrointestinal_ulcer2.58109171
14MP0002396_abnormal_hematopoietic_system2.50219155
15MP0000569_abnormal_digit_pigmentation2.49667027
16* MP0002723_abnormal_immune_serum2.49343573
17MP0003303_peritoneal_inflammation2.48200407
18MP0003436_decreased_susceptibility_to2.39143075
19MP0010094_abnormal_chromosome_stability2.38326936
20* MP0002420_abnormal_adaptive_immunity2.33748136
21MP0003763_abnormal_thymus_physiology2.32359120
22MP0002398_abnormal_bone_marrow2.32004859
23* MP0001819_abnormal_immune_cell2.31594193
24MP0002166_altered_tumor_susceptibility2.30107985
25MP0003111_abnormal_nucleus_morphology2.24398113
26MP0004808_abnormal_hematopoietic_stem2.20143773
27* MP0000716_abnormal_immune_system2.11947598
28MP0005025_abnormal_response_to2.10191064
29MP0002138_abnormal_hepatobiliary_system1.98075191
30MP0003077_abnormal_cell_cycle1.96428415
31MP0010155_abnormal_intestine_physiology1.94830933
32MP0009785_altered_susceptibility_to1.93608032
33MP0005310_abnormal_salivary_gland1.92981012
34MP0002877_abnormal_melanocyte_morpholog1.92292551
35MP0005464_abnormal_platelet_physiology1.91879993
36* MP0002419_abnormal_innate_immunity1.90682270
37MP0003183_abnormal_peptide_metabolism1.88949735
38MP0002148_abnormal_hypersensitivity_rea1.82505593
39MP0002006_tumorigenesis1.81473072
40MP0000689_abnormal_spleen_morphology1.76900543
41MP0002722_abnormal_immune_system1.74837102
42MP0002405_respiratory_system_inflammati1.73191317
43MP0009278_abnormal_bone_marrow1.71231616
44MP0004947_skin_inflammation1.70981187
45* MP0000703_abnormal_thymus_morphology1.69455219
46MP0005451_abnormal_body_composition1.69224073
47MP0003693_abnormal_embryo_hatching1.68556257
48* MP0002429_abnormal_blood_cell1.68549897
49MP0003045_fibrosis1.61870573
50MP0008260_abnormal_autophagy1.55766921
51MP0001845_abnormal_inflammatory_respons1.55122628
52MP0003172_abnormal_lysosome_physiology1.54738150
53MP0005075_abnormal_melanosome_morpholog1.53672114
54MP0001348_abnormal_lacrimal_gland1.52984818
55MP0005397_hematopoietic_system_phenotyp1.49321634
56MP0001545_abnormal_hematopoietic_system1.49321634
57MP0005174_abnormal_tail_pigmentation1.43603096
58MP0010352_gastrointestinal_tract_polyps1.35878459
59MP0006082_CNS_inflammation1.34909999
60MP0010234_abnormal_vibrissa_follicle1.34761753
61MP0003787_abnormal_imprinting1.30933392
62MP0000313_abnormal_cell_death1.26306949
63MP0000350_abnormal_cell_proliferation1.25591354
64MP0003866_abnormal_defecation1.24827149
65MP0008961_abnormal_basal_metabolism1.24244479
66MP0004381_abnormal_hair_follicle1.23765330
67MP0000465_gastrointestinal_hemorrhage1.21922005
68MP0005076_abnormal_cell_differentiation1.19165827
69MP0001853_heart_inflammation1.16731526
70MP0009333_abnormal_splenocyte_physiolog1.15254570
71MP0004957_abnormal_blastocyst_morpholog1.14566985
72MP0002693_abnormal_pancreas_physiology1.14547346
73MP0004264_abnormal_extraembryonic_tissu1.08982363
74MP0003724_increased_susceptibility_to1.08379351
75MP0008007_abnormal_cellular_replicative1.07636760
76MP0001730_embryonic_growth_arrest1.07411578
77MP0001533_abnormal_skeleton_physiology1.02295047
78MP0008469_abnormal_protein_level1.00679238
79MP0005621_abnormal_cell_physiology0.99670399
80MP0002928_abnormal_bile_duct0.98401027
81MP0003191_abnormal_cellular_cholesterol0.96488570
82MP0003091_abnormal_cell_migration0.96081481
83MP0004185_abnormal_adipocyte_glucose0.91346514
84MP0001661_extended_life_span0.90103004
85MP0002009_preneoplasia0.89777583
86MP0001851_eye_inflammation0.88028483
87MP0003453_abnormal_keratinocyte_physiol0.84591358
88MP0003566_abnormal_cell_adhesion0.82709167
89MP0001849_ear_inflammation0.80263803
90MP0000490_abnormal_crypts_of0.79511487
91MP0003984_embryonic_growth_retardation0.79408515
92MP0005380_embryogenesis_phenotype0.79248448
93MP0001672_abnormal_embryogenesis/_devel0.79248448
94MP0008058_abnormal_DNA_repair0.78869656
95MP0002088_abnormal_embryonic_growth/wei0.78795766
96MP0003868_abnormal_feces_composition0.78518860
97MP0002080_prenatal_lethality0.78444957
98MP0001944_abnormal_pancreas_morphology0.77605831
99MP0002933_joint_inflammation0.77437221
100MP0009764_decreased_sensitivity_to0.76136122
101MP0003221_abnormal_cardiomyocyte_apopto0.75930382
102MP0003786_premature_aging0.75755637
103MP0005384_cellular_phenotype0.75407968
104MP0001879_abnormal_lymphatic_vessel0.73863151
105MP0002095_abnormal_skin_pigmentation0.72453373
106MP0003656_abnormal_erythrocyte_physiolo0.71302973
107MP0009763_increased_sensitivity_to0.70146599
108MP0001346_abnormal_lacrimal_gland0.69813594
109MP0008932_abnormal_embryonic_tissue0.69739978
110MP0006035_abnormal_mitochondrial_morpho0.69536621
111MP0003943_abnormal_hepatobiliary_system0.69513861
112MP0010307_abnormal_tumor_latency0.69468347
113MP0003448_altered_tumor_morphology0.69363868
114MP0001697_abnormal_embryo_size0.68708125
115MP0002019_abnormal_tumor_incidence0.67332393
116MP0000371_diluted_coat_color0.65818028
117MP0009765_abnormal_xenobiotic_induced0.65794970
118MP0009115_abnormal_fat_cell0.63389614
119MP0001663_abnormal_digestive_system0.62623044
120MP0000609_abnormal_liver_physiology0.62294652
121MP0000733_abnormal_muscle_development0.62031374
122MP0005334_abnormal_fat_pad0.61634217
123MP0002168_other_aberrant_phenotype0.60624826
124MP0008874_decreased_physiological_sensi0.60506178
125MP0003705_abnormal_hypodermis_morpholog0.59329562
126MP0002909_abnormal_adrenal_gland0.57939379
127MP0002136_abnormal_kidney_physiology0.57698502
128MP0000767_abnormal_smooth_muscle0.55395735
129MP0005058_abnormal_lysosome_morphology0.55121409
130MP0004130_abnormal_muscle_cell0.54841454
131MP0000858_altered_metastatic_potential0.54512254
132MP0005220_abnormal_exocrine_pancreas0.53021819
133MP0001270_distended_abdomen0.52617747

Predicted human phenotypes

RankGene SetZ-score
1* Agammaglobulinemia (HP:0004432)5.44363568
2Cellulitis (HP:0100658)4.72721961
3Chronic otitis media (HP:0000389)4.50006495
4Recurrent bronchitis (HP:0002837)4.49267664
5Gastrointestinal stroma tumor (HP:0100723)4.26127263
6* Recurrent viral infections (HP:0004429)4.17031361
7* Recurrent fungal infections (HP:0002841)4.13416012
8* Colitis (HP:0002583)3.82659350
9Abnormality of the fingertips (HP:0001211)3.66663883
10* Chronic mucocutaneous candidiasis (HP:0002728)3.66608367
11* Recurrent cutaneous fungal infections (HP:0011370)3.66608367
12Eczematoid dermatitis (HP:0000976)3.64981508
13* Inflammation of the large intestine (HP:0002037)3.56316352
14* Abnormal delayed hypersensitivity skin test (HP:0002963)3.48742421
15* Gastrointestinal inflammation (HP:0004386)3.39437394
16Nasal polyposis (HP:0100582)3.34265622
17Recurrent bacterial skin infections (HP:0005406)3.29306606
18Verrucae (HP:0200043)3.22508803
19Papilloma (HP:0012740)3.22508803
20Emphysema (HP:0002097)3.21732234
21* Meningitis (HP:0001287)3.21409168
22Recurrent abscess formation (HP:0002722)3.17470681
23Vasculitis (HP:0002633)3.15904553
24Lymphopenia (HP:0001888)3.12715870
25IgM deficiency (HP:0002850)3.11247879
26* Panhypogammaglobulinemia (HP:0003139)3.05934267
27Chronic sinusitis (HP:0011109)3.04617752
28Mediastinal lymphadenopathy (HP:0100721)3.00589915
29Interstitial pulmonary disease (HP:0006530)3.00020462
30Abnormality of cells of the lymphoid lineage (HP:0012140)2.97034485
31Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.92312078
32Recurrent sinusitis (HP:0011108)2.91835178
33* Recurrent skin infections (HP:0001581)2.88679896
34Abnormality of the nasal mucosa (HP:0000433)2.88032187
35Bronchitis (HP:0012387)2.79246424
36Periodontitis (HP:0000704)2.76557512
37Thrombocytosis (HP:0001894)2.76091284
38Osteomyelitis (HP:0002754)2.72178592
39Autoimmune thrombocytopenia (HP:0001973)2.68772147
40Granulocytopenia (HP:0001913)2.61777547
41Vertebral arch anomaly (HP:0008438)2.59484423
42Microvesicular hepatic steatosis (HP:0001414)2.58111038
43Prolonged bleeding time (HP:0003010)2.55954405
44Chronic diarrhea (HP:0002028)2.55252407
45Gingival bleeding (HP:0000225)2.52638293
46Thoracic kyphosis (HP:0002942)2.51073079
47* Abnormality of T cell physiology (HP:0011840)2.47012648
48Cutaneous melanoma (HP:0012056)2.43324673
49Hematochezia (HP:0002573)2.42925943
50Basal cell carcinoma (HP:0002671)2.40471552
51* Encephalitis (HP:0002383)2.37583020
52Restrictive lung disease (HP:0002091)2.37532675
53* Abnormality of T cells (HP:0002843)2.36055651
54Pulmonary infiltrates (HP:0002113)2.36017246
55Increased IgE level (HP:0003212)2.35577231
56Recurrent gram-negative bacterial infections (HP:0005420)2.33896166
57Lip pit (HP:0100267)2.33362989
58IgA deficiency (HP:0002720)2.33049417
59Abnormality of the thoracic spine (HP:0100711)2.30583821
60Increased IgM level (HP:0003496)2.29865695
61Combined immunodeficiency (HP:0005387)2.29349460
62Persistence of primary teeth (HP:0006335)2.28693739
63Absent frontal sinuses (HP:0002688)2.28359048
64Ragged-red muscle fibers (HP:0003200)2.27169968
65T lymphocytopenia (HP:0005403)2.27121769
66Mitral stenosis (HP:0001718)2.26523366
67Squamous cell carcinoma (HP:0002860)2.26515392
68Upper motor neuron abnormality (HP:0002127)2.26398986
69Severe combined immunodeficiency (HP:0004430)2.25427675
70Abnormality of T cell number (HP:0011839)2.23997373
71Myositis (HP:0100614)2.22235827
72B lymphocytopenia (HP:0010976)2.20189826
73Abnormality of B cell number (HP:0010975)2.20189826
74Abnormality of the prostate (HP:0008775)2.20106420
75Epistaxis (HP:0000421)2.18520032
76Aplasia/Hypoplasia of the thymus (HP:0010515)2.18493820
77Progressive external ophthalmoplegia (HP:0000590)2.17401524
78Asymmetry of the thorax (HP:0001555)2.16975944
79Acute myeloid leukemia (HP:0004808)2.14605969
80Urticaria (HP:0001025)2.11035658
81Spinal cord lesions (HP:0100561)2.10917418
82Syringomyelia (HP:0003396)2.10917418
83* Viral hepatitis (HP:0006562)2.10109197
84Leukopenia (HP:0001882)2.09293361
85Fatigue (HP:0012378)2.08123733
86Hypertensive crisis (HP:0100735)2.06462999
87Chest pain (HP:0100749)2.03832056
88Skin rash (HP:0000988)2.03804926
89Abnormality of the peritoneum (HP:0002585)2.02934193
90Spontaneous hematomas (HP:0007420)2.02177958
91IgG deficiency (HP:0004315)2.01814544
92Abnormal platelet function (HP:0011869)2.00462895
93Impaired platelet aggregation (HP:0003540)2.00462895
94Metaphyseal cupping (HP:0003021)1.98670081
95Hepatosplenomegaly (HP:0001433)1.98240716
96Micronodular cirrhosis (HP:0001413)1.97762779
97Recurrent pneumonia (HP:0006532)1.97447899
98Elevated erythrocyte sedimentation rate (HP:0003565)1.97431760
99Arterial thrombosis (HP:0004420)1.97376498
100Hyperacusis (HP:0010780)1.95822967
101Sepsis (HP:0100806)1.93834234
102Abnormality of macrophages (HP:0004311)1.93393047
103Lower limb hyperreflexia (HP:0002395)1.93051131
104Thyroiditis (HP:0100646)1.91645069
105Gingivitis (HP:0000230)1.91194195
106Macroorchidism (HP:0000053)1.90147954
107Eosinophilia (HP:0001880)1.89627891
10811 pairs of ribs (HP:0000878)1.89016438
109Autoimmune hemolytic anemia (HP:0001890)1.88654854
110Deep palmar crease (HP:0006191)1.85980395
111Pustule (HP:0200039)1.84639971
112* Recurrent lower respiratory tract infections (HP:0002783)1.83052405
113Chronic obstructive pulmonary disease (HP:0006510)1.83038067
114Obstructive lung disease (HP:0006536)1.83038067
115Gastrointestinal infarctions (HP:0005244)1.81423646
116Abnormality of male internal genitalia (HP:0000022)1.80930156
117Plagiocephaly (HP:0001357)1.80324680
118Recurrent otitis media (HP:0000403)1.80264171
119* Hepatitis (HP:0012115)1.80178658
120Spastic diplegia (HP:0001264)1.79653015
121Abnormality of eosinophils (HP:0001879)1.79065092
122Progressive muscle weakness (HP:0003323)1.78579890
123Prominent nose (HP:0000448)1.78396851
124Hypergammaglobulinemia (HP:0010702)1.78150478
125Subacute progressive viral hepatitis (HP:0006572)1.77926503
126Hypoplasia of the thymus (HP:0000778)1.76591839
127Skin ulcer (HP:0200042)1.76346933
128Acute hepatic failure (HP:0006554)1.76199964
129Menorrhagia (HP:0000132)1.75508745
130Myocardial infarction (HP:0001658)1.72932883
131Abnormality of the gastric mucosa (HP:0004295)1.72722731
132Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71943227
133Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71943227
134Abnormality of polysaccharide metabolism (HP:0011012)1.71943227
135Spondylolisthesis (HP:0003302)1.71616943
136Urinary glycosaminoglycan excretion (HP:0003541)1.70884570
137Mucopolysacchariduria (HP:0008155)1.70884570
138Arthralgia (HP:0002829)1.67028725
139Aortic aneurysm (HP:0004942)1.66951219
140Lymphoma (HP:0002665)1.66671734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.69480851
2MAP4K13.59849328
3MAP3K133.55121408
4SMG13.30116243
5MAP3K142.79795290
6JAK32.71258588
7EEF2K2.49213171
8ERN12.40363876
9TYK22.35932013
10KIT2.33885021
11CAMK1D2.29913365
12MAP3K102.22485663
13RIPK42.20542021
14IKBKE2.03383807
15JAK12.00935951
16CAMK1G2.00448400
17TAOK31.92840438
18SIK21.85657742
19TBK11.82870610
20BTK1.82002391
21CDK81.75425353
22FGFR41.75053838
23FLT31.71743419
24NME21.65604752
25SYK1.63781260
26PTK61.62242440
27IKBKB1.60939415
28EPHA31.60856378
29IRAK41.56033880
30CHUK1.51648904
31ZAP701.47294369
32EPHB11.43017731
33LRRK21.40214430
34NLK1.38826021
35MAP2K31.37217587
36CSF1R1.32537067
37FGFR31.31768949
38SRPK11.31396017
39CDK121.30005823
40MAP3K71.27488564
41SIK11.26570633
42TRIB31.25143308
43TAOK21.22295844
44TEC1.17661080
45MAPK151.15793598
46HIPK21.15185304
47ICK1.14969679
48EIF2AK31.14730186
49STK101.14353546
50ITK1.11038447
51MAP3K91.10667485
52GRK61.10409080
53CDK71.09110019
54TGFBR21.08766610
55HCK1.08448614
56FES1.08328198
57MAPK111.08214681
58IRAK31.07995152
59CSK1.07887856
60LCK1.01444184
61TAOK10.99286028
62RPS6KA40.98543352
63PKN20.97019369
64JAK20.94511230
65PIM10.87867007
66RET0.87578647
67PRKD20.85271557
68ATR0.83878256
69MAP3K80.83181401
70TESK20.82572624
71TGFBR10.78017898
72CDC70.76172349
73PDGFRB0.76132783
74CDK90.76101888
75IRAK10.75509462
76BLK0.72975868
77LYN0.71662732
78ALK0.71216427
79BMPR20.69181297
80CAMKK20.68775627
81FGR0.68229807
82MATK0.67329692
83PIK3CG0.66350161
84PRKCH0.63772943
85PDK10.63484645
86SCYL20.63206456
87MARK30.61949933
88MAP3K10.61337790
89NEK90.60944425
90TNK20.56742837
91RPS6KC10.56347361
92RPS6KL10.56347361
93MARK20.56019923
94PRKCQ0.55907234
95LATS10.55508533
96CDC42BPA0.55480951
97CDK40.52655159
98CDK60.52000240
99STK30.50835399
100PRKAA20.50470394
101CHEK10.49724128
102BRD40.46935231
103DYRK1B0.46477919
104TXK0.46007135
105TTK0.45259081
106TAF10.44060337
107PASK0.43628510
108EIF2AK10.42188656
109IRAK20.41878015
110MAPKAPK20.41310608
111BCKDK0.39567679
112CAMKK10.38344877
113DMPK0.37764471
114MELK0.37464088
115RPS6KA60.37442099
116STK110.37207468
117STK40.37095122
118DYRK30.36945804
119RPS6KB20.36922791
120AURKB0.36870241
121MAPK120.36525755
122GRK10.34641637
123MST1R0.34413158
124ABL10.34365550
125RPS6KA50.34080121
126MTOR0.33417667
127PIM20.32254842
128EGFR0.32011371
129SIK30.31588883
130WNK10.31447146
131CLK10.30011316
132KSR20.29830231

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046623.24604477
2Autoimmune thyroid disease_Homo sapiens_hsa053203.07257496
3Graft-versus-host disease_Homo sapiens_hsa053322.91258439
4* Primary immunodeficiency_Homo sapiens_hsa053402.91192062
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.30438235
6Osteoclast differentiation_Homo sapiens_hsa043802.09492206
7Leishmaniasis_Homo sapiens_hsa051402.01054430
8DNA replication_Homo sapiens_hsa030301.99772977
9Measles_Homo sapiens_hsa051621.83040091
10Chronic myeloid leukemia_Homo sapiens_hsa052201.70177578
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69962588
12T cell receptor signaling pathway_Homo sapiens_hsa046601.69497065
13Acute myeloid leukemia_Homo sapiens_hsa052211.68537918
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66485502
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64307008
16Chemokine signaling pathway_Homo sapiens_hsa040621.62216771
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.61765043
18Hematopoietic cell lineage_Homo sapiens_hsa046401.60833057
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53253009
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.52767998
21Pancreatic cancer_Homo sapiens_hsa052121.50655257
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49880333
23Toxoplasmosis_Homo sapiens_hsa051451.49041684
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48758194
25Prolactin signaling pathway_Homo sapiens_hsa049171.48539020
26Other glycan degradation_Homo sapiens_hsa005111.48160916
27* Antigen processing and presentation_Homo sapiens_hsa046121.45041707
28Systemic lupus erythematosus_Homo sapiens_hsa053221.43380543
29TNF signaling pathway_Homo sapiens_hsa046681.37277464
30Base excision repair_Homo sapiens_hsa034101.36063875
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34804214
32Spliceosome_Homo sapiens_hsa030401.34250602
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33615436
34Herpes simplex infection_Homo sapiens_hsa051681.32128906
35Dorso-ventral axis formation_Homo sapiens_hsa043201.31999906
36Hepatitis B_Homo sapiens_hsa051611.29170859
37Influenza A_Homo sapiens_hsa051641.28255650
38Platelet activation_Homo sapiens_hsa046111.27832237
39Non-small cell lung cancer_Homo sapiens_hsa052231.26467140
40Type II diabetes mellitus_Homo sapiens_hsa049301.21237056
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16995394
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.15230029
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12707044
44Apoptosis_Homo sapiens_hsa042101.09901425
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06789949
46Insulin resistance_Homo sapiens_hsa049311.01736948
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00667486
48Mismatch repair_Homo sapiens_hsa034301.00113353
49Pentose phosphate pathway_Homo sapiens_hsa000300.99857707
50Non-homologous end-joining_Homo sapiens_hsa034500.99445313
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98305846
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95035436
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.94982077
54Allograft rejection_Homo sapiens_hsa053300.94413108
55African trypanosomiasis_Homo sapiens_hsa051430.93139598
56* Tuberculosis_Homo sapiens_hsa051520.91930121
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.89968835
58VEGF signaling pathway_Homo sapiens_hsa043700.89271165
59Glioma_Homo sapiens_hsa052140.89016118
60Cell cycle_Homo sapiens_hsa041100.87173756
61Small cell lung cancer_Homo sapiens_hsa052220.86800400
62mTOR signaling pathway_Homo sapiens_hsa041500.86166097
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85066937
64Thyroid cancer_Homo sapiens_hsa052160.84874138
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.84831982
66Legionellosis_Homo sapiens_hsa051340.83513999
67FoxO signaling pathway_Homo sapiens_hsa040680.83402716
68Inositol phosphate metabolism_Homo sapiens_hsa005620.81179889
69Biosynthesis of amino acids_Homo sapiens_hsa012300.80752419
70Hepatitis C_Homo sapiens_hsa051600.80646305
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79861706
72MicroRNAs in cancer_Homo sapiens_hsa052060.78914496
73Nucleotide excision repair_Homo sapiens_hsa034200.78645910
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.77202436
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76630479
76RNA transport_Homo sapiens_hsa030130.76547092
77MAPK signaling pathway_Homo sapiens_hsa040100.76476575
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76327207
79HTLV-I infection_Homo sapiens_hsa051660.76097458
80Bladder cancer_Homo sapiens_hsa052190.76011671
81Long-term potentiation_Homo sapiens_hsa047200.75558660
82Estrogen signaling pathway_Homo sapiens_hsa049150.72217336
83Viral carcinogenesis_Homo sapiens_hsa052030.72031516
84Pertussis_Homo sapiens_hsa051330.70886783
85ABC transporters_Homo sapiens_hsa020100.70840222
86Staphylococcus aureus infection_Homo sapiens_hsa051500.70257762
87Colorectal cancer_Homo sapiens_hsa052100.70026724
88Lysine degradation_Homo sapiens_hsa003100.69654118
89Shigellosis_Homo sapiens_hsa051310.67600535
90Endometrial cancer_Homo sapiens_hsa052130.66858525
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66703762
92Rheumatoid arthritis_Homo sapiens_hsa053230.66467167
93mRNA surveillance pathway_Homo sapiens_hsa030150.66226616
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.66186074
95Malaria_Homo sapiens_hsa051440.65800633
96Type I diabetes mellitus_Homo sapiens_hsa049400.64578330
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62497236
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62157880
99GnRH signaling pathway_Homo sapiens_hsa049120.61026138
100ErbB signaling pathway_Homo sapiens_hsa040120.60442496
101Amoebiasis_Homo sapiens_hsa051460.60038540
102Viral myocarditis_Homo sapiens_hsa054160.58818883
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57659348
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57335037
105Ribosome_Homo sapiens_hsa030100.56942616
106Proteoglycans in cancer_Homo sapiens_hsa052050.56765332
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56377696
108Prostate cancer_Homo sapiens_hsa052150.55698189
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54869453
110Asthma_Homo sapiens_hsa053100.54629436
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54363495
112Notch signaling pathway_Homo sapiens_hsa043300.53952139
113Choline metabolism in cancer_Homo sapiens_hsa052310.53628069
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53402965
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51927184
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51778228
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50397326
118Renal cell carcinoma_Homo sapiens_hsa052110.49396375
119Cholinergic synapse_Homo sapiens_hsa047250.48983959
120Epstein-Barr virus infection_Homo sapiens_hsa051690.48465967
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48033715
122Galactose metabolism_Homo sapiens_hsa000520.47824605
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.46732361
124Insulin signaling pathway_Homo sapiens_hsa049100.46067834
125Oxytocin signaling pathway_Homo sapiens_hsa049210.45493210
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43813673
127Phagosome_Homo sapiens_hsa041450.43399301
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.41842722
129Carbon metabolism_Homo sapiens_hsa012000.41729751
130One carbon pool by folate_Homo sapiens_hsa006700.41456815
131p53 signaling pathway_Homo sapiens_hsa041150.41326556
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.40138834
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37887859
134Fructose and mannose metabolism_Homo sapiens_hsa000510.37285347
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36372729
136HIF-1 signaling pathway_Homo sapiens_hsa040660.35923243

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