RFX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.08829859
2* endocrine pancreas development (GO:0031018)7.04880331
3peptide hormone processing (GO:0016486)6.86193844
4COPII vesicle coating (GO:0048208)6.83657026
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.77551311
6signal peptide processing (GO:0006465)6.48932839
7protein maturation by protein folding (GO:0022417)6.25417385
8protein retention in ER lumen (GO:0006621)6.07794882
9cellular ketone body metabolic process (GO:0046950)5.72013290
10regulation of type B pancreatic cell apoptotic process (GO:2000674)5.66827290
11positive regulation of insulin secretion (GO:0032024)5.66218134
12sequestering of metal ion (GO:0051238)5.56664067
13glandular epithelial cell development (GO:0002068)5.52339987
14type B pancreatic cell development (GO:0003323)5.43050311
15regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.26751087
16activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.20881313
17* glandular epithelial cell differentiation (GO:0002067)5.13053163
18vesicle coating (GO:0006901)5.05591843
19ketone body metabolic process (GO:1902224)5.04552501
20positive regulation of nuclease activity (GO:0032075)4.95772169
21insulin secretion (GO:0030073)4.93396453
22ER overload response (GO:0006983)4.85452215
23* regulation of insulin secretion (GO:0050796)4.64310850
24negative regulation of execution phase of apoptosis (GO:1900118)4.63160552
25positive regulation of peptide hormone secretion (GO:0090277)4.59122230
26regulation of nuclease activity (GO:0032069)4.53329017
27exocrine pancreas development (GO:0031017)4.48250073
28positive regulation of peptide secretion (GO:0002793)4.42534827
29intra-Golgi vesicle-mediated transport (GO:0006891)4.39169542
30endoplasmic reticulum unfolded protein response (GO:0030968)4.31661566
31columnar/cuboidal epithelial cell development (GO:0002066)4.29876912
32detection of calcium ion (GO:0005513)4.29779095
33cellular response to unfolded protein (GO:0034620)4.24580550
34* regulation of peptide hormone secretion (GO:0090276)4.24553955
35L-alpha-amino acid transmembrane transport (GO:1902475)4.23661698
36inositol phosphate catabolic process (GO:0071545)4.18541678
37cellular response to topologically incorrect protein (GO:0035967)4.17904511
38* regulation of peptide secretion (GO:0002791)4.16255599
39negative regulation of glycoprotein biosynthetic process (GO:0010561)4.13836189
40epithelial cell fate commitment (GO:0072148)4.07133304
41ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.07010836
42ER-nucleus signaling pathway (GO:0006984)4.02861525
43phosphorylated carbohydrate dephosphorylation (GO:0046838)4.02714383
44inositol phosphate dephosphorylation (GO:0046855)4.02714383
45glycerophospholipid catabolic process (GO:0046475)3.98222721
46astrocyte differentiation (GO:0048708)3.96626970
47respiratory chain complex IV assembly (GO:0008535)3.95795372
48regulation of glucocorticoid secretion (GO:2000849)3.84920379
49ER to Golgi vesicle-mediated transport (GO:0006888)3.79512417
50peptide hormone secretion (GO:0030072)3.78517492
51cellular response to vitamin D (GO:0071305)3.76947645
52peptide secretion (GO:0002790)3.70103525
53water-soluble vitamin biosynthetic process (GO:0042364)3.69604612
54* regulation of hormone secretion (GO:0046883)3.69265809
55protein N-linked glycosylation via asparagine (GO:0018279)3.66431614
56cytochrome complex assembly (GO:0017004)3.65805835
57regulation of glucokinase activity (GO:0033131)3.65424753
58regulation of hexokinase activity (GO:1903299)3.65424753
59peptidyl-asparagine modification (GO:0018196)3.65103956
60positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.63446209
61toxin metabolic process (GO:0009404)3.62506162
62positive regulation of hormone secretion (GO:0046887)3.60571893
63nitric oxide mediated signal transduction (GO:0007263)3.57077119
64positive regulation of gluconeogenesis (GO:0045722)3.56265714
65response to hepatocyte growth factor (GO:0035728)3.55226883
66cellular response to hepatocyte growth factor stimulus (GO:0035729)3.55226883
67response to endoplasmic reticulum stress (GO:0034976)3.52077004
68macroautophagy (GO:0016236)3.49440247
69negative regulation of insulin secretion (GO:0046676)3.49309333
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.48799218
71L-phenylalanine catabolic process (GO:0006559)3.48799218
72cellular zinc ion homeostasis (GO:0006882)3.44831866
73interleukin-1-mediated signaling pathway (GO:0070498)3.43882795
74inner ear receptor cell development (GO:0060119)3.40696058
75positive regulation of histone H3-K4 methylation (GO:0051571)3.40177105
76* regulation of peptide transport (GO:0090087)3.38019707
77protein N-linked glycosylation (GO:0006487)3.36406584
78protein localization to Golgi apparatus (GO:0034067)3.32927983
79response to unfolded protein (GO:0006986)3.32561183
80positive regulation of glycolytic process (GO:0045821)3.31527949
81erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.27366991
82L-phenylalanine metabolic process (GO:0006558)3.27366991
83response to topologically incorrect protein (GO:0035966)3.27047980
84nitric oxide biosynthetic process (GO:0006809)3.26270583
85reverse cholesterol transport (GO:0043691)3.25107145
86polyol catabolic process (GO:0046174)3.22869717
87negative regulation of catecholamine secretion (GO:0033604)3.22357402
88auditory receptor cell differentiation (GO:0042491)3.21944483
89GDP-mannose metabolic process (GO:0019673)3.20971744
90negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19000439
91regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.18575382
92magnesium ion transport (GO:0015693)3.18064432
93regulation of protein glycosylation (GO:0060049)3.16178956
94retinol metabolic process (GO:0042572)3.15663763
95response to hexose (GO:0009746)3.15370814
96negative regulation of JUN kinase activity (GO:0043508)3.13926840
97regulation of extracellular matrix disassembly (GO:0010715)3.13603456
98negative regulation of glycoprotein metabolic process (GO:1903019)3.12551160
99response to glucose (GO:0009749)3.10428683
100positive regulation of vesicle fusion (GO:0031340)3.07905905
101sphingomyelin metabolic process (GO:0006684)3.06806685
102negative regulation of norepinephrine secretion (GO:0010700)3.06676661
103regulation of corticosteroid hormone secretion (GO:2000846)3.06675894
104cellular response to glucagon stimulus (GO:0071377)3.05703012
105growth hormone secretion (GO:0030252)3.05684383
106negative regulation of bone resorption (GO:0045779)3.05342980
107Golgi organization (GO:0007030)3.04677513
108Golgi vesicle transport (GO:0048193)3.04213957
109hormone secretion (GO:0046879)3.04103550
110negative regulation of peptide hormone secretion (GO:0090278)3.03504010
111signal transduction involved in regulation of gene expression (GO:0023019)3.03186787
112high-density lipoprotein particle remodeling (GO:0034375)3.02787392
113positive regulation of calcium ion import (GO:0090280)3.02522669
114nucleoside diphosphate catabolic process (GO:0009134)3.01988504
115peptide transport (GO:0015833)3.00211639
116phenylpropanoid metabolic process (GO:0009698)2.98964864
117response to monosaccharide (GO:0034284)2.98844097
118protein autoprocessing (GO:0016540)2.97907970
1193-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.97831520
120purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.97831520
121negative regulation of hormone biosynthetic process (GO:0032353)2.96537571
122pteridine-containing compound biosynthetic process (GO:0042559)2.93880664
123hormone transport (GO:0009914)2.93603711
124pancreas development (GO:0031016)2.93539968
125negative regulation of peptide secretion (GO:0002792)2.91929688
126zinc ion homeostasis (GO:0055069)2.91877940
127kidney morphogenesis (GO:0060993)2.91005106
128lactate metabolic process (GO:0006089)2.90536370
129phospholipid catabolic process (GO:0009395)2.89441146
130protein targeting to Golgi (GO:0000042)2.89208463
131peptide metabolic process (GO:0006518)2.87637156
132negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.84639176
133nephron tubule morphogenesis (GO:0072078)2.77954012
134nephron epithelium morphogenesis (GO:0072088)2.77954012
135positive regulation of meiosis (GO:0045836)2.75292301
136keratinocyte development (GO:0003334)2.74500033
137zinc ion transport (GO:0006829)2.73852409
138regulation of execution phase of apoptosis (GO:1900117)2.72932006
139nodal signaling pathway (GO:0038092)2.72008961
140regulation of neurotransmitter uptake (GO:0051580)2.69576240
141intestinal cholesterol absorption (GO:0030299)2.68270791
142peptidyl-cysteine modification (GO:0018198)2.68098306
143protein complex biogenesis (GO:0070271)2.67377190
144regulation of cholesterol esterification (GO:0010872)2.65622784
145regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.65491016
146C-terminal protein lipidation (GO:0006501)2.64062839
147inositol phosphate-mediated signaling (GO:0048016)2.63242616
148renal tubule morphogenesis (GO:0061333)2.62486323
149somite rostral/caudal axis specification (GO:0032525)2.61051579
150xenobiotic catabolic process (GO:0042178)2.55520369
151positive regulation of macroautophagy (GO:0016239)2.55160026
152platelet dense granule organization (GO:0060155)2.55106550
153positive regulation of meiotic cell cycle (GO:0051446)2.55014810
154preassembly of GPI anchor in ER membrane (GO:0016254)2.54152509
155adaptation of signaling pathway (GO:0023058)2.53074184
156Golgi to endosome transport (GO:0006895)2.53069666
157negative regulation of hormone metabolic process (GO:0032351)2.52465427
158toxin transport (GO:1901998)2.52050307
159C-terminal protein amino acid modification (GO:0018410)2.51931896
160S-adenosylmethionine metabolic process (GO:0046500)2.51191451
161negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.48298881
162regulation of acyl-CoA biosynthetic process (GO:0050812)2.47694587
163cholesterol efflux (GO:0033344)2.46987704
164dendritic spine morphogenesis (GO:0060997)2.44053687
165COPI coating of Golgi vesicle (GO:0048205)10.9897985
166Golgi transport vesicle coating (GO:0048200)10.9897985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PDX1_19855005_ChIP-ChIP_MIN6_Mouse4.55411302
2GATA1_22025678_ChIP-Seq_K562_Human4.15400822
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.81204199
4GBX2_23144817_ChIP-Seq_PC3_Human2.80958682
5PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.41056193
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37876018
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.13488648
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06123620
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.01110126
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.6755289
11FUS_26573619_Chip-Seq_HEK293_Human1.96589524
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96108924
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94914009
14HTT_18923047_ChIP-ChIP_STHdh_Human1.93021160
15SOX2_27498859_Chip-Seq_STOMACH_Mouse1.91989717
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.90697243
17* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.80910618
18FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.78561688
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77521521
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76252582
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75258664
22CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.71817928
23TFEB_21752829_ChIP-Seq_HELA_Human1.71378443
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70816458
25REST_19997604_ChIP-ChIP_NEURONS_Mouse1.69353432
26P300_19829295_ChIP-Seq_ESCs_Human1.69116150
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68882702
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65765765
29NR3C1_23031785_ChIP-Seq_PC12_Mouse1.64510929
30SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.59167834
31* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.58651872
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.54612481
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.50255411
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50225483
35ER_23166858_ChIP-Seq_MCF-7_Human1.49541268
36FOXA1_25552417_ChIP-Seq_VCAP_Human1.48961644
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48942417
38* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48568361
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.48228693
40FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.45190762
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.44450697
42EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44071818
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42917383
44REST_21632747_ChIP-Seq_MESCs_Mouse1.42731065
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42551498
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39526714
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39326577
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.39209422
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.36815083
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36377709
51* AR_25329375_ChIP-Seq_VCAP_Human1.35486328
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35086071
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.33633250
54CDX2_22108803_ChIP-Seq_LS180_Human1.32844374
55P53_22387025_ChIP-Seq_ESCs_Mouse1.32831676
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32823149
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32487340
58STAT3_18555785_Chip-Seq_ESCs_Mouse1.31657545
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31527068
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31204901
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.31073825
62TAF15_26573619_Chip-Seq_HEK293_Human1.31073083
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29639325
64NANOG_19829295_ChIP-Seq_ESCs_Human1.29367262
65SOX2_19829295_ChIP-Seq_ESCs_Human1.29367262
66SOX2_18555785_Chip-Seq_ESCs_Mouse1.29323551
67* EZH2_27294783_Chip-Seq_NPCs_Mouse1.29059476
68TCF4_23295773_ChIP-Seq_U87_Human1.27637589
69IGF1R_20145208_ChIP-Seq_DFB_Human1.27269775
70* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26735173
71* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.26209778
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.25921773
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24539752
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23814461
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.23684324
76* TCF4_22108803_ChIP-Seq_LS180_Human1.22617047
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22555158
78LXR_22158963_ChIP-Seq_LIVER_Mouse1.21363537
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21311738
80ERG_20517297_ChIP-Seq_VCAP_Human1.21022527
81EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19119072
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18648540
83CBP_20019798_ChIP-Seq_JUKART_Human1.18648540
84STAT3_23295773_ChIP-Seq_U87_Human1.17608896
85EWS_26573619_Chip-Seq_HEK293_Human1.17569393
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16708964
87NMYC_18555785_Chip-Seq_ESCs_Mouse1.16636247
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15434174
89GATA1_19941826_ChIP-Seq_K562_Human1.15321107
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15320906
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14978562
92VDR_22108803_ChIP-Seq_LS180_Human1.13885031
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.13562129
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13552772
95P300_18555785_Chip-Seq_ESCs_Mouse1.13316161
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13236586
97CTCF_18555785_Chip-Seq_ESCs_Mouse1.11658863
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11583306
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10501101
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09968093
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09745314
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08993661
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.08282058
104FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08245092
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07495273
106IRF8_22096565_ChIP-ChIP_GC-B_Human1.06824810
107CLOCK_20551151_ChIP-Seq_293T_Human1.06089884
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05804083
109* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05738480
110OCT4_18555785_Chip-Seq_ESCs_Mouse1.05371227
111POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04296852
112RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03858905
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03546512
114TAL1_26923725_Chip-Seq_HPCs_Mouse1.03281589
115SMAD4_21741376_ChIP-Seq_EPCs_Human1.02727661
116ZFX_18555785_Chip-Seq_ESCs_Mouse1.02332478
117* CRX_20693478_ChIP-Seq_RETINA_Mouse1.01789230
118* RUNX2_22187159_ChIP-Seq_PCA_Human1.01429703
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01071952
120SOX2_20726797_ChIP-Seq_SW620_Human1.01046485
121NCOR_22424771_ChIP-Seq_293T_Human0.99573508
122FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99552998
123TP53_22573176_ChIP-Seq_HFKS_Human0.99307383
124CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99025203
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98882119
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98868452
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97953801
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97789052
129SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97715577
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.97672925
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97077071
132RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96700282
133RXR_22158963_ChIP-Seq_LIVER_Mouse0.95956676
134GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92761846
135FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92602532
136PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92519082
137ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89850068
138CIITA_25753668_ChIP-Seq_RAJI_Human0.89722010
139LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89416978
140BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88650434
141YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87713348
142RARB_27405468_Chip-Seq_BRAIN_Mouse0.87599910
143CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87530462
144CHD1_26751641_Chip-Seq_LNCaP_Human0.86368429
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86284361
146NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85106967
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84966035
148EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82432198
149HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.82036901
150ZNF274_21170338_ChIP-Seq_K562_Hela0.80164257
151BCAT_22108803_ChIP-Seq_LS180_Human0.78577370
152* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78353445
153* FOXA1_25329375_ChIP-Seq_VCAP_Human0.78353445
154GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78119177
155* FLI1_21867929_ChIP-Seq_TH2_Mouse0.78070318
156HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77437658
157GATA3_27048872_Chip-Seq_THYMUS_Human0.77390820
158FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77167687
159NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.76409912
160PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.75430363
161CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75401832
162SMAD4_21799915_ChIP-Seq_A2780_Human0.75228170
163SOX2_21211035_ChIP-Seq_LN229_Gbm0.75205241
164* FOXA2_19822575_ChIP-Seq_HepG2_Human0.74770023
165* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.74766434
166* AR_20517297_ChIP-Seq_VCAP_Human0.73978454
167DROSHA_22980978_ChIP-Seq_HELA_Human0.73799985
168GF1B_26923725_Chip-Seq_HPCs_Mouse0.73780819
169ETV2_25802403_ChIP-Seq_MESCs_Mouse0.73725764
170MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.73577600
171SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73081786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.42969446
2MP0000013_abnormal_adipose_tissue4.68372855
3MP0003195_calcinosis4.38502826
4MP0004043_abnormal_pH_regulation4.34027196
5MP0009780_abnormal_chondrocyte_physiolo4.26623622
6MP0002693_abnormal_pancreas_physiology4.11525248
7MP0003283_abnormal_digestive_organ3.82508476
8MP0002909_abnormal_adrenal_gland3.80729277
9MP0003183_abnormal_peptide_metabolism3.80249976
10MP0010386_abnormal_urinary_bladder3.78477611
11* MP0001944_abnormal_pancreas_morphology3.73769735
12MP0005379_endocrine/exocrine_gland_phen3.59254510
13MP0000678_abnormal_parathyroid_gland3.26655206
14MP0008877_abnormal_DNA_methylation2.93362549
15MP0002837_dystrophic_cardiac_calcinosis2.88025459
16MP0005220_abnormal_exocrine_pancreas2.79222277
17MP0005645_abnormal_hypothalamus_physiol2.52441675
18MP0002254_reproductive_system_inflammat2.50761790
19MP0000003_abnormal_adipose_tissue2.48387163
20MP0006072_abnormal_retinal_apoptosis2.39675830
21MP0002078_abnormal_glucose_homeostasis2.35964375
22MP0010329_abnormal_lipoprotein_level2.31571394
23MP0004264_abnormal_extraembryonic_tissu2.28477139
24MP0002638_abnormal_pupillary_reflex2.26460938
25MP0004019_abnormal_vitamin_homeostasis2.06362844
26MP0005646_abnormal_pituitary_gland1.99966658
27MP0005257_abnormal_intraocular_pressure1.98239708
28MP0009046_muscle_twitch1.87738120
29MP0003122_maternal_imprinting1.79676653
30MP0005332_abnormal_amino_acid1.70270187
31MP0001986_abnormal_taste_sensitivity1.69288789
32MP0001765_abnormal_ion_homeostasis1.58898433
33MP0003011_delayed_dark_adaptation1.57350287
34MP0000613_abnormal_salivary_gland1.52771410
35MP0005551_abnormal_eye_electrophysiolog1.50309712
36MP0002928_abnormal_bile_duct1.48487440
37MP0002234_abnormal_pharynx_morphology1.41448004
38MP0003953_abnormal_hormone_level1.41430490
39MP0002896_abnormal_bone_mineralization1.40858775
40MP0000516_abnormal_urinary_system1.39556399
41MP0005367_renal/urinary_system_phenotyp1.39556399
42MP0002163_abnormal_gland_morphology1.39442076
43MP0009840_abnormal_foam_cell1.38962722
44MP0005365_abnormal_bile_salt1.36260700
45MP0000462_abnormal_digestive_system1.36115985
46MP0004270_analgesia1.33755572
47MP0003172_abnormal_lysosome_physiology1.32524249
48MP0003868_abnormal_feces_composition1.31371527
49MP0008961_abnormal_basal_metabolism1.31051691
50MP0009643_abnormal_urine_homeostasis1.30221864
51MP0006292_abnormal_olfactory_placode1.29752881
52MP0008995_early_reproductive_senescence1.27400448
53MP0002138_abnormal_hepatobiliary_system1.26702217
54MP0006054_spinal_hemorrhage1.24406482
55MP0001756_abnormal_urination1.22314497
56MP0005058_abnormal_lysosome_morphology1.21842305
57MP0006036_abnormal_mitochondrial_physio1.19185725
58MP0010678_abnormal_skin_adnexa1.18896859
59MP0001984_abnormal_olfaction1.18169679
60MP0000631_abnormal_neuroendocrine_gland1.17356576
61MP0003300_gastrointestinal_ulcer1.16872565
62MP0004133_heterotaxia1.15431731
63MP0001501_abnormal_sleep_pattern1.13937314
64MP0005375_adipose_tissue_phenotype1.11955922
65MP0002090_abnormal_vision1.11605512
66MP0003959_abnormal_lean_body1.11227187
67MP0005636_abnormal_mineral_homeostasis1.10665523
68MP0005535_abnormal_body_temperature1.07212002
69MP0003252_abnormal_bile_duct1.06332832
70MP0005174_abnormal_tail_pigmentation1.05331548
71MP0002876_abnormal_thyroid_physiology1.02954523
72MP0009745_abnormal_behavioral_response1.01134797
73MP0003119_abnormal_digestive_system0.98690671
74MP0003890_abnormal_embryonic-extraembry0.98450411
75MP0005075_abnormal_melanosome_morpholog0.97227849
76MP0005084_abnormal_gallbladder_morpholo0.94687121
77MP0005310_abnormal_salivary_gland0.94246781
78MP0003787_abnormal_imprinting0.93295346
79MP0003786_premature_aging0.92857110
80MP0002938_white_spotting0.89039485
81MP0000538_abnormal_urinary_bladder0.88573165
82MP0000569_abnormal_digit_pigmentation0.88571897
83MP0002295_abnormal_pulmonary_circulatio0.88461409
84MP0002557_abnormal_social/conspecific_i0.87728772
85MP0004215_abnormal_myocardial_fiber0.84091504
86MP0005253_abnormal_eye_physiology0.83897687
87MP0005408_hypopigmentation0.83609715
88MP0005448_abnormal_energy_balance0.82353713
89MP0002064_seizures0.81897655
90MP0000427_abnormal_hair_cycle0.80283916
91MP0000383_abnormal_hair_follicle0.79891714
92MP0009672_abnormal_birth_weight0.79183407
93MP0000639_abnormal_adrenal_gland0.78324677
94MP0002272_abnormal_nervous_system0.76969824
95MP0000647_abnormal_sebaceous_gland0.76370426
96MP0001502_abnormal_circadian_rhythm0.75356758
97MP0004145_abnormal_muscle_electrophysio0.74900697
98MP0002751_abnormal_autonomic_nervous0.74495851
99MP0000681_abnormal_thyroid_gland0.74401318
100MP0002177_abnormal_outer_ear0.74294898
101MP0003866_abnormal_defecation0.74187695
102MP0008872_abnormal_physiological_respon0.73884200
103MP0001764_abnormal_homeostasis0.73455312
104MP0004142_abnormal_muscle_tone0.73300399
105MP0002139_abnormal_hepatobiliary_system0.73090412
106MP0000230_abnormal_systemic_arterial0.70759275
107MP0006035_abnormal_mitochondrial_morpho0.70750414
108MP0001905_abnormal_dopamine_level0.70422008
109MP0004085_abnormal_heartbeat0.69393636
110MP0005386_behavior/neurological_phenoty0.68560186
111MP0004924_abnormal_behavior0.68560186
112MP0000372_irregular_coat_pigmentation0.67591738
113MP0002102_abnormal_ear_morphology0.67100399
114MP0000015_abnormal_ear_pigmentation0.66847357
115MP0003186_abnormal_redox_activity0.66599190
116MP0003879_abnormal_hair_cell0.66427679
117MP0001666_abnormal_nutrient_absorption0.66030174
118MP0002168_other_aberrant_phenotype0.65612965
119MP0009703_decreased_birth_body0.64945767
120MP0001299_abnormal_eye_distance/0.60483836
121MP0005187_abnormal_penis_morphology0.60179714
122MP0002118_abnormal_lipid_homeostasis0.59405939
123MP0002733_abnormal_thermal_nociception0.57680106
124MP0001186_pigmentation_phenotype0.56989710
125MP0005452_abnormal_adipose_tissue0.56667363
126MP0010234_abnormal_vibrissa_follicle0.55909100
127MP0005334_abnormal_fat_pad0.53689875
128MP0009642_abnormal_blood_homeostasis0.52659168
129MP0004185_abnormal_adipocyte_glucose0.52228970
130MP0002734_abnormal_mechanical_nocicepti0.50219026
131MP0001661_extended_life_span0.47686086
132MP0003795_abnormal_bone_structure0.45340097
133MP0002229_neurodegeneration0.44940500
134* MP0002069_abnormal_eating/drinking_beha0.44818601
135MP0002970_abnormal_white_adipose0.44083732
136MP0000955_abnormal_spinal_cord0.42538199
137MP0004885_abnormal_endolymph0.42467845
138MP0003633_abnormal_nervous_system0.42214936
139MP0003123_paternal_imprinting0.41568303
140MP0000609_abnormal_liver_physiology0.40081249
141MP0000163_abnormal_cartilage_morphology0.39954883
142MP0003045_fibrosis0.39214134
143MP0001731_abnormal_postnatal_growth0.37405615
144MP0003121_genomic_imprinting0.37354699

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)8.62300698
2Hypoglycemic seizures (HP:0002173)7.75619506
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.91198843
4Hypoglycemic coma (HP:0001325)6.90027222
5Symptomatic seizures (HP:0011145)6.84419721
6Pancreatic islet-cell hyperplasia (HP:0004510)4.88489257
7Abnormality of endocrine pancreas physiology (HP:0012093)4.85978941
8Abnormality of the pancreatic islet cells (HP:0006476)4.85978941
9Insulin-resistant diabetes mellitus (HP:0000831)4.75380383
10Abnormality of calcium-phosphate metabolism (HP:0100530)4.68195890
11* Hyperglycemia (HP:0003074)4.44306878
12Large for gestational age (HP:0001520)4.39725135
13Ketoacidosis (HP:0001993)4.37982135
14Late onset (HP:0003584)4.24831436
15Decreased circulating renin level (HP:0003351)4.22142350
16Generalized aminoaciduria (HP:0002909)3.72931872
17Abnormal pancreas size (HP:0012094)3.71776422
18Abnormality of vitamin B metabolism (HP:0004340)3.70760200
19Urinary glycosaminoglycan excretion (HP:0003541)3.69831990
20Mucopolysacchariduria (HP:0008155)3.69831990
21Dysostosis multiplex (HP:0000943)3.56586970
22Double outlet right ventricle (HP:0001719)3.55515189
23Congenital malformation of the right heart (HP:0011723)3.55515189
24Hypokalemia (HP:0002900)3.52499907
25Osteomalacia (HP:0002749)3.44784523
26Abnormality of mucopolysaccharide metabolism (HP:0011020)3.40053944
27Abnormality of polysaccharide metabolism (HP:0011012)3.40053944
28Abnormality of glycosaminoglycan metabolism (HP:0004371)3.40053944
29Prominent metopic ridge (HP:0005487)3.24080400
30Hypoplasia of the fovea (HP:0007750)3.23003775
31Aplasia/Hypoplasia of the fovea (HP:0008060)3.23003775
32Abnormality of aromatic amino acid family metabolism (HP:0004338)3.17803936
33Abnormality of vitamin metabolism (HP:0100508)3.17343874
34Agitation (HP:0000713)3.14590560
35Hyperparathyroidism (HP:0000843)3.10950142
36Retinal atrophy (HP:0001105)3.05045373
37Abnormality of the intrinsic pathway (HP:0010989)2.98730257
38Renal cortical cysts (HP:0000803)2.98377940
39Increased CSF protein (HP:0002922)2.94871802
40Proximal tubulopathy (HP:0000114)2.92813061
41Insulin resistance (HP:0000855)2.92191398
42Dysautonomia (HP:0002459)2.87675913
43Abnormality of renin-angiotensin system (HP:0000847)2.87609086
44Methylmalonic acidemia (HP:0002912)2.87125231
45Conjugated hyperbilirubinemia (HP:0002908)2.84926380
46Abnormality of the fovea (HP:0000493)2.82313038
47Abnormality of the metopic suture (HP:0005556)2.78708479
48Abnormality of potassium homeostasis (HP:0011042)2.76883713
49Abnormality of the renal cortex (HP:0011035)2.74142090
50Medial flaring of the eyebrow (HP:0010747)2.70239500
51Progressive macrocephaly (HP:0004481)2.67094161
52Hypobetalipoproteinemia (HP:0003563)2.60936640
53Hyperactive renin-angiotensin system (HP:0000841)2.59580542
54Hyperkalemia (HP:0002153)2.55189374
55Hemiparesis (HP:0001269)2.50729258
56Enlarged penis (HP:0000040)2.50554120
57Acute necrotizing encephalopathy (HP:0006965)2.49552624
58Ketosis (HP:0001946)2.49484074
59Progressive neurologic deterioration (HP:0002344)2.48871269
60Hypothermia (HP:0002045)2.45783236
61Hepatic necrosis (HP:0002605)2.44708699
62EEG with generalized epileptiform discharges (HP:0011198)2.43873810
63Hypomagnesemia (HP:0002917)2.42396244
64Limb hypertonia (HP:0002509)2.41112621
65Hypoalbuminemia (HP:0003073)2.40792285
66Abnormal albumin level (HP:0012116)2.40792285
67Hypsarrhythmia (HP:0002521)2.40374130
68Abnormal protein glycosylation (HP:0012346)2.33373913
69Abnormal glycosylation (HP:0012345)2.33373913
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33373913
71Abnormal protein N-linked glycosylation (HP:0012347)2.33373913
72Epileptiform EEG discharges (HP:0011182)2.32069190
73Tongue fasciculations (HP:0001308)2.31782154
74Chronic bronchitis (HP:0004469)2.31560642
75Vascular calcification (HP:0004934)2.31370395
76Unilateral renal agenesis (HP:0000122)2.30239367
77Methylmalonic aciduria (HP:0012120)2.29644072
78Abnormal rod and cone electroretinograms (HP:0008323)2.29250030
79Muscular hypotonia of the trunk (HP:0008936)2.27151090
80Hyperphosphatemia (HP:0002905)2.25867817
81Postural tremor (HP:0002174)2.22833863
82Abdominal distention (HP:0003270)2.22442324
83Abnormal sex determination (HP:0012244)2.21729723
84Sex reversal (HP:0012245)2.21729723
85Acute encephalopathy (HP:0006846)2.21259396
86Mitochondrial inheritance (HP:0001427)2.19273879
87Congenital glaucoma (HP:0001087)2.19225265
88Hypotension (HP:0002615)2.18580751
89Type I transferrin isoform profile (HP:0003642)2.18409426
90Testicular neoplasm (HP:0010788)2.18368258
91Congenital stationary night blindness (HP:0007642)2.18069067
92Menstrual irregularities (HP:0000858)2.17586353
93Hypokinesia (HP:0002375)2.17069253
94Pancreatic fibrosis (HP:0100732)2.15559401
95Pheochromocytoma (HP:0002666)2.14578500
96Molar tooth sign on MRI (HP:0002419)2.11813729
97Abnormality of midbrain morphology (HP:0002418)2.11813729
98Pancreatic cysts (HP:0001737)2.10364215
99Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09103013
100Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09103013
101Increased CSF lactate (HP:0002490)2.08555504
102Hypophosphatemia (HP:0002148)2.08074581
103Polydipsia (HP:0001959)2.07995182
104Abnormal drinking behavior (HP:0030082)2.07995182
105Thoracolumbar scoliosis (HP:0002944)2.07225240
106Visual hallucinations (HP:0002367)2.06909453
107Exocrine pancreatic insufficiency (HP:0001738)2.06578985
108Increased circulating renin level (HP:0000848)2.06323506
109Hypercortisolism (HP:0001578)2.02808520
110Albinism (HP:0001022)2.02804347
111Aplasia/Hypoplasia of the macula (HP:0008059)2.01892278
112Poor suck (HP:0002033)1.99113942
113Gout (HP:0001997)1.98856347
114Congenital sensorineural hearing impairment (HP:0008527)1.98666900
115Progressive inability to walk (HP:0002505)1.98480165
116Hyperphosphaturia (HP:0003109)1.97975159
117Restlessness (HP:0000711)1.97454515
118Vacuolated lymphocytes (HP:0001922)1.97242147
119Abnormal mitochondria in muscle tissue (HP:0008316)1.97091445
120Abnormality of glycolipid metabolism (HP:0010969)1.96823565
121Abnormality of liposaccharide metabolism (HP:0010968)1.96823565
122Abnormality of glycosphingolipid metabolism (HP:0004343)1.96823565
123Abnormality of chloride homeostasis (HP:0011422)1.96802015
124Polyphagia (HP:0002591)1.94988015
125Macroorchidism (HP:0000053)1.93666474
126Aplasia/Hypoplasia affecting the retina (HP:0008061)1.93608608
127Villous atrophy (HP:0011473)1.93311789
128Abnormality of small intestinal villus morphology (HP:0011472)1.93311789
129Abnormality of renal resorption (HP:0011038)1.92834249
130Cardiovascular calcification (HP:0011915)1.92683235
1313-Methylglutaconic aciduria (HP:0003535)1.92070235
132Abnormality of the vitamin B12 metabolism (HP:0004341)1.92037170
133Nephronophthisis (HP:0000090)1.91404998
134Attenuation of retinal blood vessels (HP:0007843)1.91375823
135Generalized hyperpigmentation (HP:0007440)1.89648661
136Muscle fibrillation (HP:0010546)1.88124588
137Congenital primary aphakia (HP:0007707)1.88049894
138Steatorrhea (HP:0002570)1.88045830
139Anxiety (HP:0000739)1.87726406
140Hepatocellular necrosis (HP:0001404)1.87509468
141Hypokalemic alkalosis (HP:0001949)1.87486742
142Neuroendocrine neoplasm (HP:0100634)1.84879009
143Adrenal overactivity (HP:0002717)1.84015947
144Aplasia/hypoplasia of the uterus (HP:0008684)1.83087144
145Gait imbalance (HP:0002141)1.82272614
146Disproportionate short-trunk short stature (HP:0003521)1.81448501
147Gaze-evoked nystagmus (HP:0000640)1.81436155
148Renal Fanconi syndrome (HP:0001994)1.79463290
149True hermaphroditism (HP:0010459)1.79335552
150Hypolipoproteinemia (HP:0010981)1.79281596
151Protuberant abdomen (HP:0001538)1.78963473
152Nephrogenic diabetes insipidus (HP:0009806)1.78523991
153Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78338309
154Cortical visual impairment (HP:0100704)1.76183109
155Enlarged kidneys (HP:0000105)1.75048744
156Skin nodule (HP:0200036)1.74577136
157Bifid tongue (HP:0010297)1.71685563
158Asymmetric septal hypertrophy (HP:0001670)1.71506307
159Orthostatic hypotension (HP:0001278)1.70201157
160Hepatoblastoma (HP:0002884)1.70184805
161Papilledema (HP:0001085)1.67708574
162Abnormality of urine glucose concentration (HP:0011016)1.67090011
163Glycosuria (HP:0003076)1.67090011
164Irregular vertebral endplates (HP:0003301)1.66394162
165Hyperaldosteronism (HP:0000859)1.65223374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.92443886
2MAPK155.98867346
3PASK4.78828394
4TAOK33.43098262
5WNK33.37032616
6HIPK23.16580857
7MAP4K23.04151375
8GRK12.98878578
9MST42.94651557
10FGFR22.93297608
11PHKG12.92625776
12PHKG22.92625776
13FRK2.83820537
14ACVR1B2.68858708
15PRKD32.66520313
16WNK42.52179525
17MAP3K22.43977295
18DAPK22.17879769
19IRAK32.08777965
20ERN11.97982515
21SCYL21.87325859
22PIK3CG1.86349322
23MAP3K121.82184550
24ADRBK21.81253952
25MAP2K61.80535847
26STK31.77210198
27UHMK11.75803635
28FGFR31.66585233
29FLT31.61886206
30CDC42BPA1.57461417
31NTRK31.56335004
32CASK1.53681067
33AKT31.49822501
34MAP3K11.47514077
35IRAK11.43569963
36CSNK1G11.42454657
37CAMKK21.22833021
38PDK21.21297621
39PTK61.20603275
40MAP3K41.20117142
41TRIM281.18303710
42NTRK11.17638780
43TRPM71.15052940
44STK241.14352332
45PTK21.14298054
46EPHA31.12469270
47OXSR11.09772521
48STK391.08924027
49DYRK1B1.08354259
50PTK2B1.07084826
51PLK21.05477163
52EIF2AK31.05416430
53PAK31.04164041
54MKNK21.01956640
55TNK20.97803900
56TNIK0.97158925
57CSNK1G30.96457875
58BRSK20.95639368
59NUAK10.95172416
60CSNK1G20.92889999
61IRAK40.91161326
62IRAK20.87405004
63BCKDK0.87146474
64TRIB30.87041095
65PDGFRA0.85544730
66WNK10.84258616
67FER0.82845978
68PNCK0.80332462
69YES10.79635270
70EPHA20.73642969
71PRKCH0.72840294
72ITK0.72546947
73PRKD20.67906118
74STK40.65138083
75BRD40.65056448
76PRKCE0.63190761
77STK380.61649660
78BRAF0.61027011
79MAP3K90.59188128
80PRKAA20.57278880
81STK160.56963993
82CAMK2D0.56510132
83BMPR20.56210340
84MET0.56131904
85MAP2K20.56071935
86RPS6KA20.54895974
87STK110.54678643
88PRKCI0.54248989
89CSNK1A1L0.53425630
90LMTK20.52883339
91JAK20.50959863
92MARK20.49841825
93MYLK0.49100446
94CSNK1D0.48329005
95STK38L0.47752767
96PRKACB0.47281643
97NLK0.46369571
98SGK30.46184463
99PLK30.45697838
100MAPK130.45175071
101BRSK10.43607443
102ERBB30.43481084
103PRKG20.42687542
104PRKAA10.42596197
105CAMK2A0.42548577
106PRKG10.42345382
107KSR20.42042571
108BMPR1B0.41981546
109NME10.41582761
110RET0.41538299
111CSNK1A10.41279237
112PDK10.40651777
113SIK10.38634771
114SGK2230.38042273
115SGK4940.38042273
116PRKCZ0.37603795
117MTOR0.36335016
118AKT20.36094161
119FGFR40.35648569
120DAPK10.35302000
121GSK3A0.35268452
122CSNK1E0.34078936
123RPS6KB10.30962678
124SGK10.30872139
125OBSCN0.30662929
126ADRBK10.30574602
127BCR0.30297835
128PRKACG0.29831580
129SGK20.29210901
130PRKDC0.28598514
131CHUK0.28279760
132LATS10.28030106
133NEK60.27815930
134ATM0.27558715
135TESK10.26464142
136IGF1R0.26376751
137JAK10.25942463
138TEC0.25909810
139CAMK2B0.25222411
140ROCK10.24931109
141PRKD10.24513440
142PDPK10.24265691
143ZAK0.23710658
144MAPK140.23650931
145PRKACA0.22407439
146BTK0.22083575
147CDK50.19706054
148DYRK1A0.19616446
149MAP2K10.18999154
150MARK30.17533567
151ZAP700.16613135
152PRKCA0.16549675
153PRKCG0.16270184
154RIPK10.15732085
155RPS6KA30.14844891
156MAPK30.14734725
157PINK10.13459772
158PRKCB0.13447489

Predicted pathways (KEGG)

RankGene SetZ-score
1* Maturity onset diabetes of the young_Homo sapiens_hsa049509.39462084
2Protein export_Homo sapiens_hsa030606.06468529
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.37280710
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.35482568
5Sulfur metabolism_Homo sapiens_hsa009203.22934293
6Insulin secretion_Homo sapiens_hsa049113.22722663
7Type II diabetes mellitus_Homo sapiens_hsa049302.32563516
8Type I diabetes mellitus_Homo sapiens_hsa049402.30972135
9Vibrio cholerae infection_Homo sapiens_hsa051102.09152902
10Oxidative phosphorylation_Homo sapiens_hsa001902.06611679
11Vitamin B6 metabolism_Homo sapiens_hsa007501.94731888
12Carbohydrate digestion and absorption_Homo sapiens_hsa049731.83357229
13Selenocompound metabolism_Homo sapiens_hsa004501.76330119
14N-Glycan biosynthesis_Homo sapiens_hsa005101.74228015
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.65672676
16Propanoate metabolism_Homo sapiens_hsa006401.65626371
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62723852
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60260527
19Cocaine addiction_Homo sapiens_hsa050301.54434046
20Lysosome_Homo sapiens_hsa041421.52814550
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.52521446
22Caffeine metabolism_Homo sapiens_hsa002321.47530538
23Other glycan degradation_Homo sapiens_hsa005111.41772781
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39613624
25Circadian rhythm_Homo sapiens_hsa047101.35916841
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34580447
27Folate biosynthesis_Homo sapiens_hsa007901.32787343
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32169197
29Glutathione metabolism_Homo sapiens_hsa004801.24667747
30Fatty acid metabolism_Homo sapiens_hsa012121.21522501
31Phototransduction_Homo sapiens_hsa047441.20850398
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18393874
33Arginine biosynthesis_Homo sapiens_hsa002201.16217938
34beta-Alanine metabolism_Homo sapiens_hsa004101.15666193
35Amphetamine addiction_Homo sapiens_hsa050311.15653267
36Taste transduction_Homo sapiens_hsa047421.11769038
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10813543
38Nitrogen metabolism_Homo sapiens_hsa009101.09658485
39Parkinsons disease_Homo sapiens_hsa050121.09620020
40Glucagon signaling pathway_Homo sapiens_hsa049221.09526435
41ABC transporters_Homo sapiens_hsa020101.08592294
42Regulation of autophagy_Homo sapiens_hsa041401.00694431
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00326370
44Pancreatic secretion_Homo sapiens_hsa049720.97918601
45Thyroid hormone synthesis_Homo sapiens_hsa049180.95414348
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93383816
47Insulin resistance_Homo sapiens_hsa049310.93082863
48Tryptophan metabolism_Homo sapiens_hsa003800.92728213
49Prion diseases_Homo sapiens_hsa050200.91015496
50Alzheimers disease_Homo sapiens_hsa050100.90753361
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87757106
52Mineral absorption_Homo sapiens_hsa049780.87738383
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86012791
54Retinol metabolism_Homo sapiens_hsa008300.85510678
55Chemical carcinogenesis_Homo sapiens_hsa052040.85504678
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85467557
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84056158
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82784019
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82543662
60Butanoate metabolism_Homo sapiens_hsa006500.81194946
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79450890
62Prolactin signaling pathway_Homo sapiens_hsa049170.77193192
63Galactose metabolism_Homo sapiens_hsa000520.75847923
64Linoleic acid metabolism_Homo sapiens_hsa005910.75115548
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74154528
66Sphingolipid metabolism_Homo sapiens_hsa006000.73627049
67Steroid biosynthesis_Homo sapiens_hsa001000.73104792
68Dopaminergic synapse_Homo sapiens_hsa047280.73076114
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.72732070
70Vitamin digestion and absorption_Homo sapiens_hsa049770.70529472
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69806244
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68944901
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68147395
74Collecting duct acid secretion_Homo sapiens_hsa049660.67491489
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67203456
76Serotonergic synapse_Homo sapiens_hsa047260.65286390
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64393858
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63380385
79Circadian entrainment_Homo sapiens_hsa047130.63050211
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60950723
81Cholinergic synapse_Homo sapiens_hsa047250.60689079
82Cardiac muscle contraction_Homo sapiens_hsa042600.59867432
83Synaptic vesicle cycle_Homo sapiens_hsa047210.59327502
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59231681
85Long-term potentiation_Homo sapiens_hsa047200.58958765
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58404783
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57605808
88Huntingtons disease_Homo sapiens_hsa050160.56196830
89GABAergic synapse_Homo sapiens_hsa047270.55449417
90Phenylalanine metabolism_Homo sapiens_hsa003600.55410473
91Insulin signaling pathway_Homo sapiens_hsa049100.54590247
92Starch and sucrose metabolism_Homo sapiens_hsa005000.53688294
93Estrogen signaling pathway_Homo sapiens_hsa049150.52162577
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49632466
95Alcoholism_Homo sapiens_hsa050340.47371338
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.46631427
97Fat digestion and absorption_Homo sapiens_hsa049750.46182473
98Complement and coagulation cascades_Homo sapiens_hsa046100.43067623
99Basal transcription factors_Homo sapiens_hsa030220.42963843
100Glutamatergic synapse_Homo sapiens_hsa047240.42895352
101Lysine degradation_Homo sapiens_hsa003100.42879457
102Arginine and proline metabolism_Homo sapiens_hsa003300.42719678
103Salivary secretion_Homo sapiens_hsa049700.42104662
104Long-term depression_Homo sapiens_hsa047300.41681451
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41201899
106Antigen processing and presentation_Homo sapiens_hsa046120.40290224
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39378509
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38997239
109Histidine metabolism_Homo sapiens_hsa003400.37396411
110PPAR signaling pathway_Homo sapiens_hsa033200.37220586
111Purine metabolism_Homo sapiens_hsa002300.36951137
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36691755
113Renin secretion_Homo sapiens_hsa049240.36184651
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35904805
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35095279
116mTOR signaling pathway_Homo sapiens_hsa041500.34558445
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34554399
118Tyrosine metabolism_Homo sapiens_hsa003500.34262107
119AMPK signaling pathway_Homo sapiens_hsa041520.33306025
120Morphine addiction_Homo sapiens_hsa050320.31775961
121Thyroid cancer_Homo sapiens_hsa052160.30571249
122Protein digestion and absorption_Homo sapiens_hsa049740.29271092
123Fructose and mannose metabolism_Homo sapiens_hsa000510.28790005
124Inositol phosphate metabolism_Homo sapiens_hsa005620.27843560
125Legionellosis_Homo sapiens_hsa051340.26271078
126Dorso-ventral axis formation_Homo sapiens_hsa043200.24285315
127Phagosome_Homo sapiens_hsa041450.24279796
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22695256
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21874844
130cAMP signaling pathway_Homo sapiens_hsa040240.20751197
131Prostate cancer_Homo sapiens_hsa052150.20607024
132Fatty acid degradation_Homo sapiens_hsa000710.17782560
133Ether lipid metabolism_Homo sapiens_hsa005650.16340649
134Fatty acid elongation_Homo sapiens_hsa000620.15309193
135Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.13990945
136FoxO signaling pathway_Homo sapiens_hsa040680.12621919
137Bladder cancer_Homo sapiens_hsa052190.12476416
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10141363
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.09588235
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.08863683
141Arachidonic acid metabolism_Homo sapiens_hsa005900.07454181
142Peroxisome_Homo sapiens_hsa041460.07314069
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.06080022
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.05622647
145Ovarian steroidogenesis_Homo sapiens_hsa049130.05604092
146Metabolic pathways_Homo sapiens_hsa011000.05466853

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