RFX7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RFX7 is a member of the regulatory factor X (RFX) family of transcription factors (see RFX1, MIM 600006) (Aftab et al., 2008 [PubMed 18673564]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.57974352
2pore complex assembly (GO:0046931)4.82260042
3regulation of RNA export from nucleus (GO:0046831)4.56695452
4cytoplasmic mRNA processing body assembly (GO:0033962)4.42119062
5monoubiquitinated protein deubiquitination (GO:0035520)4.35358729
6pre-miRNA processing (GO:0031054)4.27705388
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.04772071
8regulation of NFAT protein import into nucleus (GO:0051532)3.99554078
9negative regulation of DNA repair (GO:0045738)3.97417154
10mitotic sister chromatid cohesion (GO:0007064)3.85050418
11lymphoid progenitor cell differentiation (GO:0002320)3.80424645
12definitive hemopoiesis (GO:0060216)3.76139774
13ribosomal small subunit assembly (GO:0000028)3.72991895
14regulation of nucleobase-containing compound transport (GO:0032239)3.62149190
15telomere maintenance via semi-conservative replication (GO:0032201)3.60409271
16histone H3-K36 demethylation (GO:0070544)3.42496560
17positive regulation of granulocyte differentiation (GO:0030854)3.41291477
18phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.40469877
19viral transcription (GO:0019083)3.36848774
20regulation of DNA endoreduplication (GO:0032875)3.32547736
21histone H3-K4 trimethylation (GO:0080182)3.31428203
22positive regulation by host of viral transcription (GO:0043923)3.29770055
23histone H3-K9 methylation (GO:0051567)3.28567335
24histone H4-K16 acetylation (GO:0043984)3.28222196
25telomere maintenance via recombination (GO:0000722)3.28160478
26histone H3-K9 modification (GO:0061647)3.26319204
27positive regulation of gamma-delta T cell activation (GO:0046645)3.25733956
28translational termination (GO:0006415)3.24070299
29histone lysine methylation (GO:0034968)3.22881570
30regulation of histone H3-K27 methylation (GO:0061085)3.20191606
31stress granule assembly (GO:0034063)3.16871877
32glucocorticoid receptor signaling pathway (GO:0042921)3.16295443
33mitotic recombination (GO:0006312)3.13456801
34histone H3-K9 demethylation (GO:0033169)3.12610477
35microtubule anchoring (GO:0034453)3.06222677
36DNA strand elongation involved in DNA replication (GO:0006271)3.04521676
37negative regulation of RNA splicing (GO:0033119)3.02403780
38histone lysine demethylation (GO:0070076)3.00707079
39DNA replication initiation (GO:0006270)2.98977136
40DNA strand elongation (GO:0022616)2.97452994
41DNA duplex unwinding (GO:0032508)2.96086713
42dosage compensation (GO:0007549)2.96059296
43interferon-gamma production (GO:0032609)2.95596410
44regulation of histone H3-K4 methylation (GO:0051569)2.94996241
45sister chromatid segregation (GO:0000819)2.94883830
46intra-S DNA damage checkpoint (GO:0031573)2.91730276
47T cell homeostasis (GO:0043029)2.91676540
48negative regulation of fibroblast apoptotic process (GO:2000270)2.90553622
49DNA geometric change (GO:0032392)2.90148318
50histone H3-K4 methylation (GO:0051568)2.89658906
51negative regulation of translation, ncRNA-mediated (GO:0040033)2.86579645
52regulation of translation, ncRNA-mediated (GO:0045974)2.86579645
53negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86579645
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.86420484
55histone methylation (GO:0016571)2.85738693
56positive regulation of dendritic spine morphogenesis (GO:0061003)2.83209540
57telomere maintenance via telomere lengthening (GO:0010833)2.82567332
58kinetochore organization (GO:0051383)2.81200471
59histone deubiquitination (GO:0016578)2.80725222
60ribosomal small subunit biogenesis (GO:0042274)2.80557571
61histone demethylation (GO:0016577)2.80353006
62regulation of nuclear cell cycle DNA replication (GO:0033262)2.79451166
63regulation of granulocyte differentiation (GO:0030852)2.79197244
64DNA deamination (GO:0045006)2.76610540
65positive regulation of developmental pigmentation (GO:0048087)2.76401279
66nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.75570482
67histone H4 acetylation (GO:0043967)2.74657764
68regulation of centriole replication (GO:0046599)2.74639345
69SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.74286678
70negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73487175
71NLS-bearing protein import into nucleus (GO:0006607)2.72791617
72peptidyl-lysine methylation (GO:0018022)2.72230538
73regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.70518896
74positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.70518896
75N-terminal protein amino acid acetylation (GO:0006474)2.69960104
76nucleus organization (GO:0006997)2.68952604
77regulation of chromatin silencing (GO:0031935)2.68219062
78RNA stabilization (GO:0043489)2.67926250
79mRNA stabilization (GO:0048255)2.67926250
80positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.67925584
81regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.67925584
82negative regulation of DNA-dependent DNA replication (GO:2000104)2.66588844
83embryonic hemopoiesis (GO:0035162)2.66495736
84cotranslational protein targeting to membrane (GO:0006613)2.64681042
85embryonic camera-type eye morphogenesis (GO:0048596)2.64420982
86V(D)J recombination (GO:0033151)2.64265457
87protein targeting to ER (GO:0045047)2.62449549
88positive regulation of B cell differentiation (GO:0045579)2.62230104
89corticosteroid receptor signaling pathway (GO:0031958)2.61565037
90DNA unwinding involved in DNA replication (GO:0006268)2.60999484
91DNA topological change (GO:0006265)2.60151970
92positive regulation of gene expression, epigenetic (GO:0045815)2.59499461
93translesion synthesis (GO:0019985)2.59046789
94positive regulation of histone methylation (GO:0031062)2.57415773
95histone H4-K8 acetylation (GO:0043982)2.56573387
96histone H4-K5 acetylation (GO:0043981)2.56573387
97translational elongation (GO:0006414)2.56570382
98regulation of B cell differentiation (GO:0045577)2.56429125
99histone acetylation (GO:0016573)2.56282470
100nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.56269350
101interkinetic nuclear migration (GO:0022027)2.56212841
102positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.54883967
103negative regulation of neurotransmitter secretion (GO:0046929)2.54129508
104peptidyl-lysine trimethylation (GO:0018023)2.53934967
105maturation of SSU-rRNA (GO:0030490)2.53928049
106neuronal stem cell maintenance (GO:0097150)2.53702022
107mast cell activation (GO:0045576)2.53118981
108positive regulation of mRNA catabolic process (GO:0061014)2.53009605
109negative regulation of erythrocyte differentiation (GO:0045647)2.52974471
110regulation of DNA damage checkpoint (GO:2000001)2.52973766
111regulation of histone H3-K9 methylation (GO:0051570)2.52479923
112establishment of protein localization to endoplasmic reticulum (GO:0072599)2.52354749
113protein localization to microtubule (GO:0035372)2.52059691
114mitotic chromosome condensation (GO:0007076)2.51496276
115sister chromatid cohesion (GO:0007062)2.51107370
116kinetochore assembly (GO:0051382)2.50845386
117nuclear pore complex assembly (GO:0051292)2.50800360
118nucleotide-excision repair, DNA gap filling (GO:0006297)2.50756557
119negative regulation of granulocyte differentiation (GO:0030853)2.50421527
120membrane disassembly (GO:0030397)2.50242913
121nuclear envelope disassembly (GO:0051081)2.50242913
122B cell receptor signaling pathway (GO:0050853)2.49450570
123negative regulation of mRNA processing (GO:0050686)2.49409815
124modulation by host of viral transcription (GO:0043921)2.49134353
125modulation by host of symbiont transcription (GO:0052472)2.49134353
126positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.49043024
127regulation of mRNA stability (GO:0043488)2.48578175
128mitotic nuclear envelope disassembly (GO:0007077)2.46935341
129regulation of sister chromatid cohesion (GO:0007063)2.46761864
130telomere maintenance (GO:0000723)2.46223908
131telomere organization (GO:0032200)2.46223450
132regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45982300
133protein demethylation (GO:0006482)2.45376934
134protein dealkylation (GO:0008214)2.45376934
135DNA synthesis involved in DNA repair (GO:0000731)2.44814118
136mRNA transport (GO:0051028)2.44736791
137DNA conformation change (GO:0071103)2.44145688
138protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.43630016
139T cell lineage commitment (GO:0002360)2.43607244
140regulation of histone methylation (GO:0031060)2.43407570
141regulation of T cell receptor signaling pathway (GO:0050856)2.42880726
142protein localization to endoplasmic reticulum (GO:0070972)2.42833809
143nuclear-transcribed mRNA catabolic process (GO:0000956)2.42787888
144internal peptidyl-lysine acetylation (GO:0018393)2.42469524
145antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.41995768
146antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.41995768
147positive regulation of RNA splicing (GO:0033120)2.41433236
148regulation of B cell receptor signaling pathway (GO:0050855)2.41338621
149heterochromatin organization (GO:0070828)2.41016899
150DNA ligation (GO:0006266)2.40677212
151positive regulation of histone H3-K4 methylation (GO:0051571)2.40525636
152lymphocyte homeostasis (GO:0002260)2.38831813
153negative regulation of histone methylation (GO:0031061)2.38807795
154cellular protein complex disassembly (GO:0043624)2.38805902
155meiotic chromosome segregation (GO:0045132)2.38794219
156alternative mRNA splicing, via spliceosome (GO:0000380)2.38102956
157mRNA catabolic process (GO:0006402)2.37748435
158viral life cycle (GO:0019058)2.36930978
159positive regulation of DNA-dependent DNA replication (GO:2000105)2.36599771
160T cell differentiation (GO:0030217)2.36567614
161negative regulation of myotube differentiation (GO:0010832)2.36223065
162antigen processing and presentation via MHC class Ib (GO:0002475)2.35959136
163regulation of stem cell maintenance (GO:2000036)2.35834568
164B cell differentiation (GO:0030183)2.34702171
165DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.34437814
166CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.34240773
167myeloid dendritic cell activation (GO:0001773)2.33606813
168histone mRNA catabolic process (GO:0071044)2.33344008
169lymph node development (GO:0048535)2.33313531
170protein complex disassembly (GO:0043241)2.31188646
171B cell homeostasis (GO:0001782)2.31041266
172generation of neurons (GO:0048699)2.30771263
173mRNA splice site selection (GO:0006376)2.30654046
174translational initiation (GO:0006413)2.30635944
175megakaryocyte development (GO:0035855)2.29390956
176RNA catabolic process (GO:0006401)2.29205894
177protein-DNA complex disassembly (GO:0032986)2.28356784
178nucleosome disassembly (GO:0006337)2.28356784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.48184283
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.96767266
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61624625
4SCL_19346495_ChIP-Seq_HPC-7_Human3.52356108
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46636178
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.15022767
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.14980561
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.08979641
9* MYC_22102868_ChIP-Seq_BL_Human2.76823719
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74864451
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.72223877
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.69487459
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.65298454
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.60437611
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.57738010
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53787888
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.53304538
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45173781
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.40430667
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.24990398
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23066596
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21738193
23WT1_19549856_ChIP-ChIP_CCG9911_Human2.19329251
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18106472
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16571254
26CIITA_25753668_ChIP-Seq_RAJI_Human2.09983615
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.02251503
28MYC_18555785_ChIP-Seq_MESCs_Mouse2.01394371
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00686431
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.00492680
31VDR_21846776_ChIP-Seq_THP-1_Human1.99476533
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.99135083
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98296006
34TAF15_26573619_Chip-Seq_HEK293_Human1.97250200
35* MYB_26560356_Chip-Seq_TH2_Human1.96584517
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.94827885
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90684898
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90009409
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89286725
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89215436
41SPI1_23547873_ChIP-Seq_NB4_Human1.85611180
42AR_21572438_ChIP-Seq_LNCaP_Human1.85133603
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81463451
44RUNX_20019798_ChIP-Seq_JUKART_Human1.80759628
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.80727809
46* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78991894
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78244167
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.77196293
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75989040
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.75664974
51* MYB_26560356_Chip-Seq_TH1_Human1.71271599
52* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70210232
53SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.67788141
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66357601
55VDR_24763502_ChIP-Seq_THP-1_Human1.62851173
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59798892
57* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.58207916
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56792622
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55782853
60FOXP3_21729870_ChIP-Seq_TREG_Human1.55614926
61VDR_23849224_ChIP-Seq_CD4+_Human1.55355339
62* MAF_26560356_Chip-Seq_TH1_Human1.51294115
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.47562000
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.47483712
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47212163
66FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.46963464
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46198650
68EZH2_22144423_ChIP-Seq_EOC_Human1.45938059
69ELK1_19687146_ChIP-ChIP_HELA_Human1.43511695
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42276972
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42148314
72* TCF7_22412390_ChIP-Seq_EML_Mouse1.41021374
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40641445
74* UTX_26944678_Chip-Seq_JUKART_Human1.40105955
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38034531
76SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.37651138
77GBX2_23144817_ChIP-Seq_PC3_Human1.37324010
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.36279439
79IGF1R_20145208_ChIP-Seq_DFB_Human1.34532876
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.32385815
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30454643
82* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27948031
83* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27792847
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27695765
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27427887
86STAT3_23295773_ChIP-Seq_U87_Human1.26764090
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26628978
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26463559
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25812826
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25541301
91SOX9_26525672_Chip-Seq_HEART_Mouse1.25515432
92ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25339784
93MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23544466
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23301379
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.23076835
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21924092
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21627688
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20981381
99EWS_26573619_Chip-Seq_HEK293_Human1.19444279
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19082410
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18778936
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17309252
103LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16557129
104FLI1_27457419_Chip-Seq_LIVER_Mouse1.14683403
105MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12877291
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12855858
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12596014
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08754739
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08754739
110SPI1_23127762_ChIP-Seq_K562_Human1.08293269
111GATA1_22025678_ChIP-Seq_K562_Human1.08047602
112PU_27001747_Chip-Seq_BMDM_Mouse1.07508266
113* SMAD4_21799915_ChIP-Seq_A2780_Human1.07339439
114IRF8_27001747_Chip-Seq_BMDM_Mouse1.06697054
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.06646438
116TTF2_22483619_ChIP-Seq_HELA_Human1.06516544
117KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06012692
118KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06012692
119KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06012692
120* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05655067
121STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05482596
122RNF2_27304074_Chip-Seq_NSC_Mouse1.05145752
123MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04400997
124P300_19829295_ChIP-Seq_ESCs_Human1.04355443
125AR_21909140_ChIP-Seq_LNCAP_Human1.03013405
126TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01953976
127* ISL1_27105846_Chip-Seq_CPCs_Mouse1.01573928
128TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01188341
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00210327
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98352012
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.98172275
132POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97969812
133GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97640203
134MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97634541
135EST1_17652178_ChIP-ChIP_JURKAT_Human0.97568212
136IRF1_19129219_ChIP-ChIP_H3396_Human0.96661232
137* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96147551
138BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96120171
139ER_23166858_ChIP-Seq_MCF-7_Human0.96107879
140KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94768975
141FLI1_21867929_ChIP-Seq_TH2_Mouse0.94693322
142* TCF4_23295773_ChIP-Seq_U87_Human0.94331388
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94016069
144TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93335629
145RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92985480
146PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92288165
147FUS_26573619_Chip-Seq_HEK293_Human0.92004499
148PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91899012
149GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91580828
150POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90986305
151XRN2_22483619_ChIP-Seq_HELA_Human0.90693900
152EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89539528
153TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89518934
154E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88835787
155TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87374068
156EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87035895
157IRF8_21731497_ChIP-ChIP_J774_Mouse0.86571828
158NFE2_27457419_Chip-Seq_LIVER_Mouse0.85445615
159MYC_18940864_ChIP-ChIP_HL60_Human0.85256473
160HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.82670745
161SMAD_19615063_ChIP-ChIP_OVARY_Human0.82647318
162PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81775221
163ETS1_22383799_ChIP-Seq_G1ME_Mouse0.80839397
164E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80572892
165MYCN_18555785_ChIP-Seq_MESCs_Mouse0.78913776
166* MAF_26560356_Chip-Seq_TH2_Human0.77741919

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.67496885
2MP0005174_abnormal_tail_pigmentation3.35993994
3MP0006292_abnormal_olfactory_placode3.02352094
4MP0003890_abnormal_embryonic-extraembry3.00209233
5MP0005409_darkened_coat_color2.92542424
6MP0008057_abnormal_DNA_replication2.73958346
7MP0003763_abnormal_thymus_physiology2.62139912
8MP0001188_hyperpigmentation2.58101020
9MP0000015_abnormal_ear_pigmentation2.54121084
10MP0004808_abnormal_hematopoietic_stem2.53792957
11MP0010094_abnormal_chromosome_stability2.51244546
12MP0001835_abnormal_antigen_presentation2.42438212
13MP0002095_abnormal_skin_pigmentation2.36586677
14MP0005671_abnormal_response_to2.35032836
15MP0005075_abnormal_melanosome_morpholog2.34928932
16MP0008058_abnormal_DNA_repair2.10667274
17MP0009379_abnormal_foot_pigmentation2.08999768
18MP0003122_maternal_imprinting2.08344592
19MP0000490_abnormal_crypts_of2.06384574
20MP0002398_abnormal_bone_marrow2.04758752
21MP0001800_abnormal_humoral_immune2.02700868
22MP0003693_abnormal_embryo_hatching1.97047173
23MP0002166_altered_tumor_susceptibility1.95671767
24MP0000685_abnormal_immune_system1.90301896
25MP0005076_abnormal_cell_differentiation1.87114168
26MP0000569_abnormal_digit_pigmentation1.81155878
27MP0001545_abnormal_hematopoietic_system1.76630603
28MP0005397_hematopoietic_system_phenotyp1.76630603
29MP0000703_abnormal_thymus_morphology1.74606249
30MP0003077_abnormal_cell_cycle1.74575291
31MP0003984_embryonic_growth_retardation1.74516303
32MP0004197_abnormal_fetal_growth/weight/1.73170944
33MP0001986_abnormal_taste_sensitivity1.72637966
34MP0002420_abnormal_adaptive_immunity1.71534995
35MP0002006_tumorigenesis1.68920307
36MP0003111_abnormal_nucleus_morphology1.68640917
37MP0002088_abnormal_embryonic_growth/wei1.67979346
38MP0004381_abnormal_hair_follicle1.67547013
39MP0001819_abnormal_immune_cell1.67389357
40MP0008007_abnormal_cellular_replicative1.67095240
41MP0002452_abnormal_antigen_presenting1.65486054
42MP0005380_embryogenesis_phenotype1.64636827
43MP0001672_abnormal_embryogenesis/_devel1.64636827
44MP0009697_abnormal_copulation1.64591115
45MP0002723_abnormal_immune_serum1.62793570
46MP0000716_abnormal_immune_system1.62219047
47MP0002009_preneoplasia1.56957019
48MP0002722_abnormal_immune_system1.56768640
49MP0001730_embryonic_growth_arrest1.54749682
50MP0009703_decreased_birth_body1.54024929
51MP0002084_abnormal_developmental_patter1.53703132
52MP0000689_abnormal_spleen_morphology1.53275269
53MP0000465_gastrointestinal_hemorrhage1.51631838
54MP0005000_abnormal_immune_tolerance1.47892788
55MP0005387_immune_system_phenotype1.45532034
56MP0001790_abnormal_immune_system1.45532034
57MP0003941_abnormal_skin_development1.40440500
58MP0002938_white_spotting1.40246368
59MP0001286_abnormal_eye_development1.39604252
60MP0009333_abnormal_splenocyte_physiolog1.39521744
61MP0002429_abnormal_blood_cell1.39016215
62MP0005025_abnormal_response_to1.38727089
63MP0001697_abnormal_embryo_size1.38526733
64MP0003136_yellow_coat_color1.37851377
65MP0009785_altered_susceptibility_to1.37553850
66MP0002086_abnormal_extraembryonic_tissu1.35214497
67MP0009672_abnormal_birth_weight1.35066467
68MP0000778_abnormal_nervous_system1.34577663
69MP0001873_stomach_inflammation1.33136034
70MP0002085_abnormal_embryonic_tissue1.30148655
71MP0004134_abnormal_chest_morphology1.27429917
72MP0003866_abnormal_defecation1.24525386
73MP0003935_abnormal_craniofacial_develop1.22858223
74MP0000428_abnormal_craniofacial_morphol1.22502429
75MP0002405_respiratory_system_inflammati1.19982915
76MP0003436_decreased_susceptibility_to1.18890375
77MP0003385_abnormal_body_wall1.18649731
78MP0003861_abnormal_nervous_system1.17501571
79MP0010155_abnormal_intestine_physiology1.16995866
80MP0001915_intracranial_hemorrhage1.16414516
81MP0003937_abnormal_limbs/digits/tail_de1.14948444
82MP0004957_abnormal_blastocyst_morpholog1.14466010
83MP0002697_abnormal_eye_size1.14177573
84MP0002075_abnormal_coat/hair_pigmentati1.11861089
85MP0003787_abnormal_imprinting1.11294488
86MP0002080_prenatal_lethality1.09511733
87MP0002148_abnormal_hypersensitivity_rea1.07722478
88MP0002019_abnormal_tumor_incidence1.07314581
89MP0003121_genomic_imprinting1.05631598
90MP0008961_abnormal_basal_metabolism1.04852865
91MP0002081_perinatal_lethality1.03754589
92MP0003724_increased_susceptibility_to1.03557549
93MP0002177_abnormal_outer_ear1.03427151
94MP0000372_irregular_coat_pigmentation1.02917730
95MP0000432_abnormal_head_morphology1.02741915
96MP0002419_abnormal_innate_immunity1.01386276
97MP0009278_abnormal_bone_marrow1.01226796
98MP0003303_peritoneal_inflammation1.00723067
99MP0003115_abnormal_respiratory_system0.98686747
100MP0003221_abnormal_cardiomyocyte_apopto0.98550724
101MP0008877_abnormal_DNA_methylation0.97286981
102MP0001853_heart_inflammation0.96382860
103MP0005464_abnormal_platelet_physiology0.93821932
104MP0003755_abnormal_palate_morphology0.93442771
105MP0002233_abnormal_nose_morphology0.92907006
106MP0003656_abnormal_erythrocyte_physiolo0.92258042
107MP0002114_abnormal_axial_skeleton0.90426038
108MP0002925_abnormal_cardiovascular_devel0.90294612
109MP0005645_abnormal_hypothalamus_physiol0.89892395
110MP0001293_anophthalmia0.89718803
111MP0000566_synostosis0.88544048
112MP0000733_abnormal_muscle_development0.88501965
113MP0001177_atelectasis0.88472218
114MP0002822_catalepsy0.88470276
115MP0001186_pigmentation_phenotype0.88251896
116MP0005621_abnormal_cell_physiology0.87227305
117MP0001299_abnormal_eye_distance/0.86866358
118MP0000350_abnormal_cell_proliferation0.86323096
119MP0000313_abnormal_cell_death0.86074407
120MP0000371_diluted_coat_color0.84805376
121MP0010630_abnormal_cardiac_muscle0.83981660
122MP0000383_abnormal_hair_follicle0.83007548
123MP0003786_premature_aging0.82962713
124MP0002092_abnormal_eye_morphology0.82636946
125MP0004185_abnormal_adipocyte_glucose0.79941325
126MP0003943_abnormal_hepatobiliary_system0.79292332
127MP0002116_abnormal_craniofacial_bone0.79076769
128MP0003567_abnormal_fetal_cardiomyocyte0.78845869
129MP0003123_paternal_imprinting0.78689903
130MP0001340_abnormal_eyelid_morphology0.77104375
131MP0002152_abnormal_brain_morphology0.76203648
132MP0002751_abnormal_autonomic_nervous0.75479334
133MP0000631_abnormal_neuroendocrine_gland0.74765153
134MP0000762_abnormal_tongue_morphology0.74454874
135MP0000955_abnormal_spinal_cord0.73947630
136MP0010678_abnormal_skin_adnexa0.73888524
137MP0009250_abnormal_appendicular_skeleto0.73122118
138MP0000049_abnormal_middle_ear0.72899542
139MP0010770_preweaning_lethality0.72578154
140MP0002082_postnatal_lethality0.72578154
141MP0005384_cellular_phenotype0.72314912
142MP0008789_abnormal_olfactory_epithelium0.71961794
143MP0000534_abnormal_ureter_morphology0.71803102
144MP0000579_abnormal_nail_morphology0.71006582
145MP0010769_abnormal_survival0.70894880
146MP0003183_abnormal_peptide_metabolism0.66322702
147MP0000681_abnormal_thyroid_gland0.65517988
148MP0003300_gastrointestinal_ulcer0.65215078
149MP0010307_abnormal_tumor_latency0.64727744
150MP0008995_early_reproductive_senescence0.64609125
151MP0000858_altered_metastatic_potential0.64359816
152MP0001845_abnormal_inflammatory_respons0.63070918
153MP0003938_abnormal_ear_development0.61637069
154MP0000613_abnormal_salivary_gland0.61502452
155MP0002163_abnormal_gland_morphology0.61145329
156MP0002210_abnormal_sex_determination0.60580138
157MP0003828_pulmonary_edema0.58952609
158MP0002102_abnormal_ear_morphology0.58785040
159MP0008932_abnormal_embryonic_tissue0.57802517
160MP0010352_gastrointestinal_tract_polyps0.57787081
161MP0002928_abnormal_bile_duct0.56379089
162MP0005394_taste/olfaction_phenotype0.55388935

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)3.65310113
2Type I transferrin isoform profile (HP:0003642)3.62221403
3Abnormality of the fingertips (HP:0001211)3.57808719
4Chromsome breakage (HP:0040012)3.47160309
5Reduced antithrombin III activity (HP:0001976)3.31894408
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.25575320
7Aplastic anemia (HP:0001915)3.21317125
8IgM deficiency (HP:0002850)3.20046887
9Volvulus (HP:0002580)3.14534388
10Acute lymphatic leukemia (HP:0006721)3.12045407
11Panhypogammaglobulinemia (HP:0003139)3.07789949
12Reticulocytopenia (HP:0001896)3.07422191
13Abnormality of the columella (HP:0009929)3.04756605
14Hepatoblastoma (HP:0002884)2.90628965
15Agammaglobulinemia (HP:0004432)2.89356856
16Abnormal hair whorl (HP:0010721)2.88914012
17Acute myeloid leukemia (HP:0004808)2.79015742
18Thrombocytosis (HP:0001894)2.78173538
19Meningitis (HP:0001287)2.74531906
20Heterotopia (HP:0002282)2.74290933
21Abnormal number of erythroid precursors (HP:0012131)2.67640260
22Recurrent viral infections (HP:0004429)2.65318897
23Thyroid carcinoma (HP:0002890)2.62687519
24Myositis (HP:0100614)2.61268557
25Abnormality of cells of the erythroid lineage (HP:0012130)2.60939184
26Abnormality of B cell number (HP:0010975)2.60170221
27B lymphocytopenia (HP:0010976)2.60170221
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.59927296
29Thyroiditis (HP:0100646)2.57635430
30Abnormality of chromosome stability (HP:0003220)2.53858519
31Recurrent cutaneous fungal infections (HP:0011370)2.52630359
32Chronic mucocutaneous candidiasis (HP:0002728)2.52630359
33Elevated erythrocyte sedimentation rate (HP:0003565)2.49576171
34Recurrent fungal infections (HP:0002841)2.49175866
35Deep philtrum (HP:0002002)2.47109998
36Myelodysplasia (HP:0002863)2.45993888
37Severe visual impairment (HP:0001141)2.45202140
38Abnormal protein glycosylation (HP:0012346)2.41193131
39Abnormal glycosylation (HP:0012345)2.41193131
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.41193131
41Abnormal protein N-linked glycosylation (HP:0012347)2.41193131
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.40531004
43Clubbing of toes (HP:0100760)2.39158281
44Broad face (HP:0000283)2.35256639
45Narrow palate (HP:0000189)2.34298936
46Abnormality of the preputium (HP:0100587)2.33559863
47Lymphoma (HP:0002665)2.32285939
48Abnormality of DNA repair (HP:0003254)2.31517477
49Genetic anticipation (HP:0003743)2.30375321
50Prolonged bleeding time (HP:0003010)2.26082711
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23793610
52Long eyelashes (HP:0000527)2.20402894
53Broad palm (HP:0001169)2.19732483
54Pallor (HP:0000980)2.18539636
55Chronic obstructive pulmonary disease (HP:0006510)2.17933640
56Obstructive lung disease (HP:0006536)2.17933640
57Urethral obstruction (HP:0000796)2.17651059
58Meckel diverticulum (HP:0002245)2.16621565
59Recurrent bronchitis (HP:0002837)2.15471446
60Transitional cell carcinoma of the bladder (HP:0006740)2.15139691
61Ectopic kidney (HP:0000086)2.14525387
62Abnormality of the ileum (HP:0001549)2.14040900
63Lip pit (HP:0100267)2.13715170
64Aplasia/Hypoplasia of the sternum (HP:0006714)2.12839706
65Rhabdomyosarcoma (HP:0002859)2.12730440
66Supernumerary ribs (HP:0005815)2.12587168
67Trigonocephaly (HP:0000243)2.11493576
68Medulloblastoma (HP:0002885)2.11318251
69IgG deficiency (HP:0004315)2.11050867
70Embryonal neoplasm (HP:0002898)2.08068423
71Bladder neoplasm (HP:0009725)2.07876073
72Bladder carcinoma (HP:0002862)2.07876073
73Abnormality of the prostate (HP:0008775)2.07575425
74Abnormality of T cells (HP:0002843)2.07574554
75Abnormality of the carotid arteries (HP:0005344)2.07546736
76Cortical dysplasia (HP:0002539)2.07214161
77Chronic otitis media (HP:0000389)2.06756379
78Overlapping toe (HP:0001845)2.06421569
79Hip dysplasia (HP:0001385)2.05289340
80Lymphopenia (HP:0001888)2.03842719
81Abnormality of incisor morphology (HP:0011063)2.03528791
82Severe combined immunodeficiency (HP:0004430)2.02672321
83T lymphocytopenia (HP:0005403)2.01151564
84Cellulitis (HP:0100658)1.99940216
85Abnormal number of incisors (HP:0011064)1.99751732
86Prominent nose (HP:0000448)1.99590484
87Abnormality of T cell physiology (HP:0011840)1.99471303
88Uterine leiomyosarcoma (HP:0002891)1.99135331
89Leiomyosarcoma (HP:0100243)1.99135331
90Mediastinal lymphadenopathy (HP:0100721)1.98736846
91Vertebral arch anomaly (HP:0008438)1.98665945
92Termporal pattern (HP:0011008)1.97847472
93Insidious onset (HP:0003587)1.97847472
94Amaurosis fugax (HP:0100576)1.97728205
95Cystic hygroma (HP:0000476)1.97417464
96Abnormality of the left ventricular outflow tract (HP:0011103)1.97288797
97Subaortic stenosis (HP:0001682)1.97288797
98Optic nerve coloboma (HP:0000588)1.97267753
99Asymmetry of the thorax (HP:0001555)1.96064782
100Large earlobe (HP:0009748)1.95624336
101Inflammation of the large intestine (HP:0002037)1.94561197
102Neoplasm of striated muscle (HP:0009728)1.94519258
103Abnormality of cells of the lymphoid lineage (HP:0012140)1.94020278
104Diastasis recti (HP:0001540)1.93749784
105Tubulointerstitial nephritis (HP:0001970)1.93055153
106Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.92944209
107Gastrointestinal carcinoma (HP:0002672)1.92901922
108Malignant gastrointestinal tract tumors (HP:0006749)1.92901922
109Thick eyebrow (HP:0000574)1.92217925
110Gastrointestinal inflammation (HP:0004386)1.91059589
111Supernumerary bones of the axial skeleton (HP:0009144)1.90622209
112Long clavicles (HP:0000890)1.90391980
113Obsessive-compulsive behavior (HP:0000722)1.89605881
114Anal stenosis (HP:0002025)1.88176700
115Abnormality of the nasal septum (HP:0000419)1.87177811
116Abnormality of the distal phalanx of the thumb (HP:0009617)1.85955871
117High anterior hairline (HP:0009890)1.85278907
118Hypoplastic labia majora (HP:0000059)1.85219380
119Nephroblastoma (Wilms tumor) (HP:0002667)1.85208142
120Neonatal hypoglycemia (HP:0001998)1.83478685
121Abnormality of T cell number (HP:0011839)1.82574270
122Sandal gap (HP:0001852)1.82231867
123Depressed nasal tip (HP:0000437)1.82210552
124Colon cancer (HP:0003003)1.81937530
125Generalized hypotonia (HP:0001290)1.81558917
126Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81354260
127Short 4th metacarpal (HP:0010044)1.81354260
128Missing ribs (HP:0000921)1.81313522
129Tapered finger (HP:0001182)1.81151752
130Abnormality of the labia minora (HP:0012880)1.80574781
131Low anterior hairline (HP:0000294)1.79016078
132Macroorchidism (HP:0000053)1.78086317
133Midline defect of the nose (HP:0004122)1.77459733
134Poikiloderma (HP:0001029)1.76521050
135Bone marrow hypocellularity (HP:0005528)1.76131960
136Increased nuchal translucency (HP:0010880)1.76130931
137Abnormality of chromosome segregation (HP:0002916)1.76082075
138Hypoplastic iliac wings (HP:0002866)1.75700398
139Encephalitis (HP:0002383)1.74860136
140Curly hair (HP:0002212)1.73325899
141Truncal obesity (HP:0001956)1.71396703
142Broad alveolar ridges (HP:0000187)1.70950730
143Leukopenia (HP:0001882)1.69604504
144Abnormality of the labia majora (HP:0012881)1.68897539
145Retrobulbar optic neuritis (HP:0100654)1.68232189
146Optic neuritis (HP:0100653)1.68232189
147Facial hemangioma (HP:0000329)1.67278285
148Basal cell carcinoma (HP:0002671)1.66901774
149Aqueductal stenosis (HP:0002410)1.66839997
150Recurrent abscess formation (HP:0002722)1.66541877
151Embryonal renal neoplasm (HP:0011794)1.66167399
152Petechiae (HP:0000967)1.65900331
153Chest pain (HP:0100749)1.65889274
154Vasculitis (HP:0002633)1.65486555
155Cutis marmorata (HP:0000965)1.64813017
156Small intestinal stenosis (HP:0012848)1.64577825
157Duodenal stenosis (HP:0100867)1.64577825
158Abnormality of the parietal bone (HP:0002696)1.63741348
159Relative macrocephaly (HP:0004482)1.63505303
160Nonprogressive disorder (HP:0003680)1.63443963
161Neoplasm of the adrenal cortex (HP:0100641)1.63152357
162Attenuation of retinal blood vessels (HP:0007843)1.62923960
163Thyroid-stimulating hormone excess (HP:0002925)1.62355697
164Neoplasm of the oral cavity (HP:0100649)1.62063037
165Hypoplasia of the thymus (HP:0000778)1.61447963
166Broad thumb (HP:0011304)1.61320316
167Cafe-au-lait spot (HP:0000957)1.61273340
168Drooling (HP:0002307)1.60289957
1692-3 toe syndactyly (HP:0004691)1.60179204
170Tented upper lip vermilion (HP:0010804)1.58977639
171Impulsivity (HP:0100710)1.58963335
172Deeply set eye (HP:0000490)1.58307046
173Broad ribs (HP:0000885)1.58200633
174Capillary hemangiomas (HP:0005306)1.56541643
175Intestinal fistula (HP:0100819)1.54746955
176Decreased lacrimation (HP:0000633)1.54609358
177Broad phalanges of the hand (HP:0009768)1.54213211

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.65171949
2MKNK23.08903238
3MAP4K12.72797762
4NLK2.49444629
5TEC2.47807968
6MKNK12.35679338
7TXK2.31500725
8EIF2AK32.14490633
9MUSK2.12499113
10CDK122.05117754
11SGK22.05002554
12KIT2.04260456
13CDC71.95759521
14AKT31.94936133
15LATS11.94888659
16BTK1.89939237
17TAF11.87989551
18PASK1.84073221
19IRAK41.75120942
20FGFR21.69277399
21BRD41.59894082
22PNCK1.57440899
23SRPK11.57228867
24STK161.54356958
25SGK31.47338591
26WEE11.46478349
27FLT31.45067508
28WNK11.43477144
29CSF1R1.40615995
30EEF2K1.39583954
31NME21.35896415
32YES11.34441752
33VRK11.33625258
34SGK4941.32985435
35SGK2231.32985435
36EIF2AK21.32709209
37CLK11.30972223
38ATR1.28433879
39FES1.26658495
40TLK11.24523436
41JAK31.24127270
42DYRK31.22151062
43CAMKK21.18927189
44CDK71.17680927
45FGFR11.14056713
46PRPF4B1.13858690
47FGFR41.13770802
48TYRO31.13556622
49SIK21.12860245
50HIPK21.12426373
51SIK31.10411307
52ACVR1B1.09898908
53ICK1.08917770
54NEK21.07994725
55IRAK31.07592160
56SYK1.07529550
57CDK191.06598593
58PDGFRA1.06476418
59RPS6KA41.05287761
60CDK41.04800427
61CDK31.01849163
62BCR1.01689989
63PIM10.98752177
64CAMK10.98543463
65MAP3K40.98195447
66BRSK20.97865738
67PLK40.97572779
68MELK0.96933711
69NEK90.96440621
70MAP3K70.95786766
71PRKD20.93497109
72CDK90.93084817
73MARK20.92950164
74SCYL20.92848652
75CASK0.90391027
76TSSK60.89566981
77ZAK0.88813382
78MAPK130.88211962
79NTRK20.86998276
80LYN0.85974950
81RPS6KB20.85826745
82ZAP700.84543125
83TAOK30.83624609
84LCK0.82753945
85ITK0.82285943
86IKBKB0.81839331
87CDK80.81159171
88MTOR0.80570138
89CAMK1D0.79539579
90PIM20.77479857
91BLK0.77234203
92EIF2AK10.77218907
93CDK60.77008574
94TTK0.76422829
95HCK0.76121694
96STK30.75751549
97MAP3K100.75612459
98MARK10.74986756
99STK100.73439660
100CHEK20.72681961
101MAPK100.70834235
102IKBKE0.69882875
103CAMK40.69116147
104TGFBR10.67886185
105ATM0.64567549
106CHUK0.62945233
107IRAK10.62415912
108NEK10.61307338
109MATK0.59008023
110STK40.58824133
111CDK10.58189500
112NUAK10.58175883
113TGFBR20.57973250
114RET0.57714285
115SGK10.57180723
116PKN20.57056746
117PRKCH0.56925141
118AURKB0.56805182
119CHEK10.56733988
120UHMK10.55432131
121TNK20.54246276
122FGFR30.52803056
123DYRK1A0.52623083
124PDGFRB0.52522726
125CAMK1G0.52011067
126MAP3K60.51481446
127GSK3B0.51451455
128TYK20.50137398
129GRK60.49333906
130EPHA30.49068604
131CCNB10.48935003
132STK240.48274404
133MAP3K20.47728737
134DYRK1B0.46748349
135CSNK1G10.46401832
136CSK0.45729355
137MAP2K70.45617306
138MAPK40.45085145
139MAPK140.44744711
140RPS6KB10.44323734
141CSNK1A1L0.44180887
142STK38L0.42722080
143ADRBK20.42583958
144RPS6KA50.42538158
145PRKDC0.40930427
146PLK30.40518524
147CDK20.39506458
148CSNK1E0.39032345
149AKT10.38396916
150CAMKK10.37631118

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.30595168
2Primary immunodeficiency_Homo sapiens_hsa053402.73229875
3Mismatch repair_Homo sapiens_hsa034302.47341585
4Homologous recombination_Homo sapiens_hsa034402.45161224
5Ribosome_Homo sapiens_hsa030102.32568897
6Fanconi anemia pathway_Homo sapiens_hsa034602.31815090
7Non-homologous end-joining_Homo sapiens_hsa034502.21384919
8Base excision repair_Homo sapiens_hsa034102.08845015
9Spliceosome_Homo sapiens_hsa030401.87523330
10Transcriptional misregulation in cancer_Homo sapiens_hsa052021.66017908
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.64886304
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64751651
13Cell cycle_Homo sapiens_hsa041101.63501874
14Herpes simplex infection_Homo sapiens_hsa051681.58112232
15Nucleotide excision repair_Homo sapiens_hsa034201.57812428
16Adherens junction_Homo sapiens_hsa045201.57506639
17Measles_Homo sapiens_hsa051621.52276664
18B cell receptor signaling pathway_Homo sapiens_hsa046621.51644008
19Hematopoietic cell lineage_Homo sapiens_hsa046401.51496742
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.49545147
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45663687
22ErbB signaling pathway_Homo sapiens_hsa040121.45314412
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44367094
24RNA degradation_Homo sapiens_hsa030181.44266500
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42219776
26Glioma_Homo sapiens_hsa052141.39302266
27Dorso-ventral axis formation_Homo sapiens_hsa043201.39276205
28Renal cell carcinoma_Homo sapiens_hsa052111.38897068
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34896048
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33721320
31p53 signaling pathway_Homo sapiens_hsa041151.29887389
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28747140
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.25749466
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24135748
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23974851
36Basal transcription factors_Homo sapiens_hsa030221.23893045
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23487233
38mTOR signaling pathway_Homo sapiens_hsa041501.22365213
39Acute myeloid leukemia_Homo sapiens_hsa052211.21278255
40Leishmaniasis_Homo sapiens_hsa051401.20467807
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18913450
42T cell receptor signaling pathway_Homo sapiens_hsa046601.18215105
43Choline metabolism in cancer_Homo sapiens_hsa052311.16556821
44Long-term potentiation_Homo sapiens_hsa047201.16020352
45Pyrimidine metabolism_Homo sapiens_hsa002401.13482401
46RNA transport_Homo sapiens_hsa030131.12801190
47Antigen processing and presentation_Homo sapiens_hsa046121.12480154
48mRNA surveillance pathway_Homo sapiens_hsa030151.11866034
49Thyroid cancer_Homo sapiens_hsa052161.11279237
50N-Glycan biosynthesis_Homo sapiens_hsa005101.10407177
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07287380
52RNA polymerase_Homo sapiens_hsa030201.06843230
53Allograft rejection_Homo sapiens_hsa053301.06014822
54Oocyte meiosis_Homo sapiens_hsa041141.04883652
55TGF-beta signaling pathway_Homo sapiens_hsa043501.03405671
56Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02610798
57Hepatitis B_Homo sapiens_hsa051611.00683290
58One carbon pool by folate_Homo sapiens_hsa006700.98431635
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98212649
60Estrogen signaling pathway_Homo sapiens_hsa049150.96848037
61Asthma_Homo sapiens_hsa053100.96284307
62Colorectal cancer_Homo sapiens_hsa052100.95931946
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.94367915
64Osteoclast differentiation_Homo sapiens_hsa043800.93414292
65HTLV-I infection_Homo sapiens_hsa051660.91257525
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89619916
67MicroRNAs in cancer_Homo sapiens_hsa052060.89322174
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88970190
69Hippo signaling pathway_Homo sapiens_hsa043900.86543920
70Long-term depression_Homo sapiens_hsa047300.84966069
71Epstein-Barr virus infection_Homo sapiens_hsa051690.84441324
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83958387
73Melanoma_Homo sapiens_hsa052180.83495350
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82099919
75Axon guidance_Homo sapiens_hsa043600.81984216
76Small cell lung cancer_Homo sapiens_hsa052220.81937027
77Viral carcinogenesis_Homo sapiens_hsa052030.81843611
78Notch signaling pathway_Homo sapiens_hsa043300.81376494
79Chronic myeloid leukemia_Homo sapiens_hsa052200.80987475
80Steroid biosynthesis_Homo sapiens_hsa001000.80987297
81Influenza A_Homo sapiens_hsa051640.77406007
82MAPK signaling pathway_Homo sapiens_hsa040100.76113275
83Systemic lupus erythematosus_Homo sapiens_hsa053220.75091506
84AMPK signaling pathway_Homo sapiens_hsa041520.73844149
85Hedgehog signaling pathway_Homo sapiens_hsa043400.73814583
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.72745312
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71127316
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71017336
89Wnt signaling pathway_Homo sapiens_hsa043100.70911378
90Gap junction_Homo sapiens_hsa045400.69426521
91Glucagon signaling pathway_Homo sapiens_hsa049220.68693942
92Insulin signaling pathway_Homo sapiens_hsa049100.68614481
93Melanogenesis_Homo sapiens_hsa049160.67928902
94Protein export_Homo sapiens_hsa030600.67474609
95Basal cell carcinoma_Homo sapiens_hsa052170.67319486
96Purine metabolism_Homo sapiens_hsa002300.66974709
97Platelet activation_Homo sapiens_hsa046110.65790502
98Graft-versus-host disease_Homo sapiens_hsa053320.64724112
99Autoimmune thyroid disease_Homo sapiens_hsa053200.64335892
100Toxoplasmosis_Homo sapiens_hsa051450.64056719
101Viral myocarditis_Homo sapiens_hsa054160.63920457
102Taste transduction_Homo sapiens_hsa047420.62417049
103Chemokine signaling pathway_Homo sapiens_hsa040620.62258774
104Proteoglycans in cancer_Homo sapiens_hsa052050.61854075
105Pancreatic cancer_Homo sapiens_hsa052120.61637633
106Prostate cancer_Homo sapiens_hsa052150.61563457
107Pathways in cancer_Homo sapiens_hsa052000.61311964
108Non-small cell lung cancer_Homo sapiens_hsa052230.61241648
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.60187631
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59839372
111Lysine degradation_Homo sapiens_hsa003100.57983241
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57909437
113TNF signaling pathway_Homo sapiens_hsa046680.57031602
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56368881
115Apoptosis_Homo sapiens_hsa042100.55962832
116VEGF signaling pathway_Homo sapiens_hsa043700.55335429
117Circadian rhythm_Homo sapiens_hsa047100.55169259
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54213914
119Insulin resistance_Homo sapiens_hsa049310.53142671
120Endometrial cancer_Homo sapiens_hsa052130.51789738
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.51463723
122Shigellosis_Homo sapiens_hsa051310.51274944
123Other glycan degradation_Homo sapiens_hsa005110.50768042
124Oxytocin signaling pathway_Homo sapiens_hsa049210.49285706
125Type II diabetes mellitus_Homo sapiens_hsa049300.48943073
126Cholinergic synapse_Homo sapiens_hsa047250.48514736
127Alcoholism_Homo sapiens_hsa050340.48454616
128Phototransduction_Homo sapiens_hsa047440.48344061
129Tuberculosis_Homo sapiens_hsa051520.47321867
130Focal adhesion_Homo sapiens_hsa045100.47297046
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47144473
132Ras signaling pathway_Homo sapiens_hsa040140.45944010
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45233440
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45149222
135Hepatitis C_Homo sapiens_hsa051600.44984978
136Nicotine addiction_Homo sapiens_hsa050330.44576351
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43959733
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.43220028
139Malaria_Homo sapiens_hsa051440.42363361
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40582586
141Type I diabetes mellitus_Homo sapiens_hsa049400.40183267
142Inositol phosphate metabolism_Homo sapiens_hsa005620.39889697
143FoxO signaling pathway_Homo sapiens_hsa040680.38054150
144Prolactin signaling pathway_Homo sapiens_hsa049170.37393256
145Pertussis_Homo sapiens_hsa051330.36777524
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35706036
147Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32544309

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »