RFX8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.94836220
2motile cilium assembly (GO:0044458)9.53156636
3epithelial cilium movement (GO:0003351)9.37360659
4spermatid development (GO:0007286)9.08265267
5male meiosis (GO:0007140)8.91310465
6reproduction (GO:0000003)8.79320778
7synaptonemal complex organization (GO:0070193)8.22987906
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.96997194
9cilium movement (GO:0003341)7.92759221
10synaptonemal complex assembly (GO:0007130)7.88618022
11regulation of cilium movement (GO:0003352)7.44900020
12single fertilization (GO:0007338)7.14163873
13DNA methylation involved in gamete generation (GO:0043046)6.99816320
14fertilization (GO:0009566)6.22253490
15male meiosis I (GO:0007141)6.10283660
16spermatogenesis (GO:0007283)6.09951141
17sperm capacitation (GO:0048240)6.08258654
18male gamete generation (GO:0048232)6.07819154
19negative regulation of inclusion body assembly (GO:0090084)5.78855292
20seminiferous tubule development (GO:0072520)5.64383200
21gamete generation (GO:0007276)5.59732938
22chromosome organization involved in meiosis (GO:0070192)5.59109783
23microtubule depolymerization (GO:0007019)5.56134507
24meiotic nuclear division (GO:0007126)5.47793139
25germ cell development (GO:0007281)5.25001829
26ventricular system development (GO:0021591)5.24044457
27organic cation transport (GO:0015695)5.23542967
28cellular process involved in reproduction in multicellular organism (GO:0022412)5.21184211
29mesenchymal-epithelial cell signaling (GO:0060638)5.02743984
30meiosis I (GO:0007127)4.90288607
31cell recognition (GO:0008037)4.74431532
32regulation of inclusion body assembly (GO:0090083)4.68443192
33calcium ion-dependent exocytosis (GO:0017156)4.67816131
34negative regulation of erythrocyte differentiation (GO:0045647)4.47452352
35meiotic cell cycle (GO:0051321)4.46215632
36response to peptidoglycan (GO:0032494)4.44532911
37mannose metabolic process (GO:0006013)4.41397100
38multicellular organismal reproductive process (GO:0048609)4.36939751
39negative regulation of smooth muscle cell migration (GO:0014912)4.29927841
40endodermal cell differentiation (GO:0035987)4.29276412
41protein localization to cilium (GO:0061512)4.26959642
42regulation of microtubule-based movement (GO:0060632)4.26817044
43pinocytosis (GO:0006907)4.26587989
44cellular extravasation (GO:0045123)4.24693293
45microtubule severing (GO:0051013)4.21928793
46left/right pattern formation (GO:0060972)4.06409192
47genitalia morphogenesis (GO:0035112)3.90926510
48definitive hemopoiesis (GO:0060216)3.90379578
49gene silencing by RNA (GO:0031047)3.87094464
50glycerol ether metabolic process (GO:0006662)3.84291940
51response to muramyl dipeptide (GO:0032495)3.84116188
52intraciliary transport (GO:0042073)3.72670050
53chaperone-mediated protein complex assembly (GO:0051131)3.69736954
54chromosome condensation (GO:0030261)3.69375440
55mature B cell differentiation involved in immune response (GO:0002313)3.67318305
56negative regulation of granulocyte differentiation (GO:0030853)3.66971197
57negative regulation of interleukin-8 production (GO:0032717)3.65129894
58protein polyglutamylation (GO:0018095)3.64502937
59multicellular organismal development (GO:0007275)3.60926857
60cellular response to exogenous dsRNA (GO:0071360)3.60737049
61DNA packaging (GO:0006323)3.58941337
62monoubiquitinated protein deubiquitination (GO:0035520)3.55160622
63ether metabolic process (GO:0018904)3.54729784
64mitotic sister chromatid cohesion (GO:0007064)3.54647343
65neutrophil mediated immunity (GO:0002446)3.52442641
66spermatid nucleus differentiation (GO:0007289)3.51374174
67meiotic cell cycle process (GO:1903046)3.45221018
68lactate metabolic process (GO:0006089)3.44918947
69substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.43251861
70substrate-independent telencephalic tangential migration (GO:0021826)3.43251861
71regulation of monocyte differentiation (GO:0045655)3.42386876
72regulation of centriole replication (GO:0046599)3.40637141
73vascular endothelial growth factor signaling pathway (GO:0038084)3.40361080
74regulation of spindle checkpoint (GO:0090231)3.39951729
75regulation of macrophage cytokine production (GO:0010935)3.38589870
76substrate-dependent cell migration (GO:0006929)3.37371023
77negative regulation of organelle assembly (GO:1902116)3.36929720
78axoneme assembly (GO:0035082)3.35932981
79UV protection (GO:0009650)3.34966094
80positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.34578339
81synapsis (GO:0007129)3.32923544
82glial cell migration (GO:0008347)3.32236740
83positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.31762159
84regulation of chemokine biosynthetic process (GO:0045073)3.29437803
85regulation of meiosis I (GO:0060631)3.27352298
86amino-acid betaine transport (GO:0015838)3.23561853
87carnitine transport (GO:0015879)3.23561853
88carnitine transmembrane transport (GO:1902603)3.21497239
89alditol metabolic process (GO:0019400)3.21057594
90sequestering of extracellular ligand from receptor (GO:0035581)3.19305588
91polyol catabolic process (GO:0046174)3.14109894
92regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.13908686
93protein heterotrimerization (GO:0070208)3.09448800
94positive regulation of steroid hormone secretion (GO:2000833)3.06839327
95positive regulation of B cell differentiation (GO:0045579)3.06316444
96negative regulation of homotypic cell-cell adhesion (GO:0034111)3.05997845
97regulation of response to osmotic stress (GO:0047484)3.05125775
98phospholipid translocation (GO:0045332)3.03834545
99lipid translocation (GO:0034204)3.03834545
100microtubule-based movement (GO:0007018)3.02161246
101sequestering of actin monomers (GO:0042989)3.02144714
102hypotonic response (GO:0006971)3.01881578
103protein localization to endosome (GO:0036010)2.99816117
104positive regulation of odontogenesis (GO:0042482)2.97239718
105hyaluronan catabolic process (GO:0030214)2.93658605
106regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.92554707
107negative regulation of nitric oxide biosynthetic process (GO:0045019)2.92406085
108cilium organization (GO:0044782)2.92171558
109microtubule polymerization or depolymerization (GO:0031109)2.91185015
110protein K11-linked deubiquitination (GO:0035871)2.90631238
111positive regulation of chemokine biosynthetic process (GO:0045080)2.87733511
112centriole assembly (GO:0098534)2.87404088
113adhesion of symbiont to host cell (GO:0044650)2.86540070
114virion attachment to host cell (GO:0019062)2.86540070
115macrophage differentiation (GO:0030225)2.86300695
116gene silencing (GO:0016458)2.86140741
117skin morphogenesis (GO:0043589)2.85774381
118glycerol metabolic process (GO:0006071)2.85713535
119uterus development (GO:0060065)2.85493170
120cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.85396374
121positive regulation of DNA biosynthetic process (GO:2000573)2.84721509
122vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.84573611
123barbed-end actin filament capping (GO:0051016)2.83033628
124chondrocyte proliferation (GO:0035988)2.82859512
125cortical actin cytoskeleton organization (GO:0030866)2.82696133
126type B pancreatic cell proliferation (GO:0044342)2.82612023
127protein refolding (GO:0042026)2.82255653
128hemoglobin metabolic process (GO:0020027)2.82237874
129negative regulation of B cell apoptotic process (GO:0002903)2.82209748
130phosphatidylglycerol biosynthetic process (GO:0006655)2.82098132
131negative regulation of biomineral tissue development (GO:0070168)2.81433653
132regulation of platelet aggregation (GO:0090330)2.80620264
133potassium ion export (GO:0071435)2.80193199
134sister chromatid cohesion (GO:0007062)2.79999222
135positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.79220543
136negative regulation of fatty acid transport (GO:2000192)2.78337995
137regulation of growth of symbiont in host (GO:0044126)2.78310777
138negative regulation of growth of symbiont in host (GO:0044130)2.78310777
139negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.78310777
140modulation of growth of symbiont involved in interaction with host (GO:0044144)2.78310777
141cilium assembly (GO:0042384)2.78288430
142regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.78133738
143chondroitin sulfate biosynthetic process (GO:0030206)2.76990809
144cellular component assembly involved in morphogenesis (GO:0010927)2.76466236
145regulation of vitamin D biosynthetic process (GO:0060556)2.76046553
146cilium morphogenesis (GO:0060271)2.75240596
147nucleoside diphosphate phosphorylation (GO:0006165)2.74478959
148negative regulation of bone mineralization (GO:0030502)2.74221168
149positive regulation of granulocyte differentiation (GO:0030854)2.73785299
150positive regulation of astrocyte differentiation (GO:0048711)2.73161837
151cellular response to zinc ion (GO:0071294)2.72599110
152negative regulation of DNA repair (GO:0045738)2.72530258
153centriole replication (GO:0007099)2.70494882
154negative regulation of bone remodeling (GO:0046851)2.70370704
155blood vessel maturation (GO:0001955)2.70206490
156regulation of gonadotropin secretion (GO:0032276)2.68620667
157myeloid leukocyte mediated immunity (GO:0002444)2.66630697
158negative regulation of blood vessel endothelial cell migration (GO:0043537)2.66374857
159negative regulation of type 2 immune response (GO:0002829)2.66356060
160mature B cell differentiation (GO:0002335)2.66069742
161positive regulation of macrophage cytokine production (GO:0060907)2.65452380
162DNA alkylation (GO:0006305)2.64910654
163DNA methylation (GO:0006306)2.64910654
164cortical cytoskeleton organization (GO:0030865)2.64427140
165regulation of protein polyubiquitination (GO:1902914)2.63614597
166histone exchange (GO:0043486)2.63040493
167glycolytic process (GO:0006096)2.62541847
168peptidyl-glutamic acid modification (GO:0018200)2.61134536
169neuronal ion channel clustering (GO:0045161)2.60769314
170nuclear pore complex assembly (GO:0051292)2.59920704
171maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.59571348
172stress fiber assembly (GO:0043149)2.59018834
173negative regulation of neurotransmitter secretion (GO:0046929)2.55041881
174collagen catabolic process (GO:0030574)2.52427560
175regulation of integrin activation (GO:0033623)2.52327473
176protein retention in ER lumen (GO:0006621)2.51820427
177regulation of B cell differentiation (GO:0045577)2.48109639
178collagen metabolic process (GO:0032963)2.46643535
179phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.45446163
180negative regulation of monooxygenase activity (GO:0032769)2.45379312
181regulation of B cell apoptotic process (GO:0002902)2.44387220
182negative regulation of nitric-oxide synthase activity (GO:0051001)2.43262100
183negative regulation of interleukin-6 production (GO:0032715)2.42516179
184cellular response to vitamin D (GO:0071305)2.40743604
185mRNA transcription (GO:0009299)2.40729568
186fusion of sperm to egg plasma membrane (GO:0007342)13.4264724
187cilium or flagellum-dependent cell motility (GO:0001539)13.0155511
188sperm motility (GO:0030317)11.8233477
189sperm-egg recognition (GO:0035036)11.1404475
190acrosome assembly (GO:0001675)11.1087013
191piRNA metabolic process (GO:0034587)10.8904664
192cell wall macromolecule catabolic process (GO:0016998)10.7462988
193cell wall macromolecule metabolic process (GO:0044036)10.7462988
194multicellular organism reproduction (GO:0032504)10.7433574
195acrosome reaction (GO:0007340)10.3230183
196binding of sperm to zona pellucida (GO:0007339)10.2843213
197plasma membrane fusion (GO:0045026)10.2528771
198axonemal dynein complex assembly (GO:0070286)10.1779013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.36137859
2VDR_21846776_ChIP-Seq_THP-1_Human4.62055789
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.43080040
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.34851158
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.26297022
6VDR_24763502_ChIP-Seq_THP-1_Human4.12224317
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.31776477
8MYB_21317192_ChIP-Seq_ERMYB_Mouse2.89459411
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.89081186
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.87520916
11SCL_19346495_ChIP-Seq_HPC-7_Human2.86354930
12* ELK3_25401928_ChIP-Seq_HUVEC_Human2.79766290
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.65139187
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.63919035
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.53467560
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52315811
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.51246066
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.49036583
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.47545321
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44129958
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37884114
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.31595344
23VDR_24787735_ChIP-Seq_THP-1_Human2.31036587
24CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.30912921
25KDM2B_26808549_Chip-Seq_SUP-B15_Human2.27121133
26* FLI1_27457419_Chip-Seq_LIVER_Mouse2.14280313
27KDM2B_26808549_Chip-Seq_DND41_Human2.13734305
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.11982593
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03827849
30* BRD4_25478319_ChIP-Seq_HGPS_Human2.03443657
31* ZNF274_21170338_ChIP-Seq_K562_Hela2.03087529
32* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.02206126
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.7709903
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.99093611
35* IRF8_27001747_Chip-Seq_BMDM_Mouse1.97486157
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.95177482
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94961671
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94565347
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.90796557
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.90565976
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87931319
42VDR_22108803_ChIP-Seq_LS180_Human1.86590950
43UTX_26944678_Chip-Seq_JUKART_Human1.85383753
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.83444652
45* SPI1_23547873_ChIP-Seq_NB4_Human1.81228744
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80054663
47* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78113646
48ELK4_26923725_Chip-Seq_MESODERM_Mouse1.75262916
49* LXR_22292898_ChIP-Seq_THP-1_Human1.74938414
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.70961253
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70071804
52* STAT1_17558387_ChIP-Seq_HELA_Human1.66441005
53* KDM2B_26808549_Chip-Seq_JURKAT_Human1.64875482
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.64467425
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64314571
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.63928569
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.63307536
58TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.62501166
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62494387
60JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61492753
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58179985
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56867726
63KAP1_22055183_ChIP-Seq_ESCs_Mouse1.56373314
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56168066
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55417206
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54690812
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54547904
68FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53062081
69TAL1_26923725_Chip-Seq_HPCs_Mouse1.50877841
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.49587656
71SMC1_22415368_ChIP-Seq_MEFs_Mouse1.47235646
72WDR5_24793694_ChIP-Seq_LNCAP_Human1.46668510
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46323226
74SPI1_23127762_ChIP-Seq_K562_Human1.46302349
75GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.45251862
76GATA3_21867929_ChIP-Seq_CD8_Mouse1.44074731
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.43561044
78MAF_26560356_Chip-Seq_TH1_Human1.41258429
79SOX2_22085726_ChIP-Seq_NPCs_Mouse1.40693607
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40293469
81MYC_22102868_ChIP-Seq_BL_Human1.39097613
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.37587104
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.37580470
84UBF1/2_26484160_Chip-Seq_HMECs_Human1.37062549
85KDM2B_26808549_Chip-Seq_REH_Human1.36843091
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.36210633
87KDM2B_26808549_Chip-Seq_K562_Human1.35000985
88JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34950174
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34667522
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31836242
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31377502
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30937163
93* MYB_26560356_Chip-Seq_TH2_Human1.30518263
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30168945
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27927367
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27221461
97* NFE2_27457419_Chip-Seq_LIVER_Mouse1.26640273
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25615327
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25122863
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24792108
101CBP_20019798_ChIP-Seq_JUKART_Human1.24376058
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24376058
103FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22957363
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22655752
105RUNX_20019798_ChIP-Seq_JUKART_Human1.21835077
106FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.21176469
107SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20661338
108SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19933018
109LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19196064
110ELF1_20517297_ChIP-Seq_JURKAT_Human1.19120062
111LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.18371672
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.18255626
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17842621
114IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16747650
115P53_21459846_ChIP-Seq_SAOS-2_Human1.16256539
116GATA3_21867929_ChIP-Seq_TH1_Mouse1.15742367
117GF1_26923725_Chip-Seq_HPCs_Mouse1.14708337
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13693923
119CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13470115
120MYB_26560356_Chip-Seq_TH1_Human1.13324872
121* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13182127
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11967474
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09598953
124TP63_17297297_ChIP-ChIP_HaCaT_Human1.09444267
125* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09409350
126* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08624706
127* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08547500
128* REST_21632747_ChIP-Seq_MESCs_Mouse1.08372146
129FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08364501
130ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07898129
131SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07449323
132* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06662056
133RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06318132
134GATA1_19941827_ChIP-Seq_MEL_Mouse1.05953457
135* CRX_20693478_ChIP-Seq_RETINA_Mouse1.05600913
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05450149
137RNF2_27304074_Chip-Seq_NSC_Mouse1.05412140
138EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05117265
139TP53_22127205_ChIP-Seq_IMR90_Human1.04774257
140EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04494599
141PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04105591
142RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04092410
143CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03899260
144GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03484061
145NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03007662
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01833764
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00726315
148NCOR1_26117541_ChIP-Seq_K562_Human1.00360848
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99501344
150ERG_20517297_ChIP-Seq_VCAP_Human0.99025485
151MAF_26560356_Chip-Seq_TH2_Human0.98938460
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98724233
153SPI1_26923725_Chip-Seq_HPCs_Mouse0.98719676
154CJUN_26792858_Chip-Seq_BT549_Human0.98289681
155* OCT4_18555785_Chip-Seq_ESCs_Mouse0.97596884
156* NANOG_18555785_Chip-Seq_ESCs_Mouse0.97554811
157* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97032976
158TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96150425
159POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96150425
160* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95853526
161* EZH2_27294783_Chip-Seq_NPCs_Mouse0.94855007
162ESET_19884257_ChIP-Seq_ESCs_Mouse0.94466457
163* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93727090
164TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93020034
165YY1_22570637_ChIP-Seq_MALME-3M_Human0.92776063
166EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92645948
167CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92280898
168SOX2_21211035_ChIP-Seq_LN229_Human0.91928229
169* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91236706
170WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90358025
171GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89827371
172SOX9_26525672_Chip-Seq_HEART_Mouse0.89337790
173E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89081946
174SA1_22415368_ChIP-Seq_MEFs_Mouse0.88663633
175FLI1_21867929_ChIP-Seq_CD8_Mouse0.88610261
176RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88510209
177* P53_22387025_ChIP-Seq_ESCs_Mouse0.88463410
178BCAT_22108803_ChIP-Seq_LS180_Human0.87972089
179NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86875154
180* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86832870
181MYC_27129775_Chip-Seq_CORNEA_Mouse0.86544435
182* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86330027
183* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86120435
184RARA_24833708_ChIP-Seq_LIVER_Mouse0.85999504
185* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.84681582
186* KLF4_18555785_Chip-Seq_ESCs_Mouse0.84375283
187* P300_18555785_Chip-Seq_ESCs_Mouse0.83997238
188* STAT3_18555785_Chip-Seq_ESCs_Mouse0.83804230
189KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83428267
190PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83276377
191ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82591902
192* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82457371
193* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.82414169
194NFYB_21822215_ChIP-Seq_K562_Human0.82208365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.98765070
2MP0003698_abnormal_male_reproductive5.83748887
3MP0008438_abnormal_cutaneous_collagen5.51298450
4MP0001929_abnormal_gametogenesis5.50594266
5MP0003279_aneurysm3.86425085
6MP0002210_abnormal_sex_determination3.79600330
7MP0009278_abnormal_bone_marrow3.24131506
8MP0001145_abnormal_male_reproductive3.20414799
9MP0002161_abnormal_fertility/fecundity3.16661482
10MP0003172_abnormal_lysosome_physiology3.09070671
11MP0001542_abnormal_bone_strength2.85472029
12MP0000653_abnormal_sex_gland2.81022022
13MP0006054_spinal_hemorrhage2.74083219
14MP0002653_abnormal_ependyma_morphology2.61091834
15MP0005058_abnormal_lysosome_morphology2.59814398
16MP0003705_abnormal_hypodermis_morpholog2.36429853
17MP0005503_abnormal_tendon_morphology2.34180594
18MP0009384_cardiac_valve_regurgitation2.33372270
19MP0003436_decreased_susceptibility_to2.31746346
20MP0008057_abnormal_DNA_replication2.25788677
21MP0001958_emphysema2.25444171
22MP0002396_abnormal_hematopoietic_system2.20266870
23MP0008004_abnormal_stomach_pH2.15761641
24MP0002160_abnormal_reproductive_system2.03833632
25MP0005410_abnormal_fertilization14.7776763
26MP0005275_abnormal_skin_tensile1.98245248
27MP0001853_heart_inflammation1.95600066
28MP0002998_abnormal_bone_remodeling1.94343631
29MP0005464_abnormal_platelet_physiology1.94223034
30MP0002419_abnormal_innate_immunity1.92538049
31MP0002282_abnormal_trachea_morphology1.78990483
32MP0005508_abnormal_skeleton_morphology1.78239756
33MP0003091_abnormal_cell_migration1.75861296
34MP0003646_muscle_fatigue1.75716184
35MP0009840_abnormal_foam_cell1.75326323
36MP0010368_abnormal_lymphatic_system1.69842851
37MP0003828_pulmonary_edema1.69499124
38MP0008058_abnormal_DNA_repair1.62307126
39MP0005390_skeleton_phenotype1.60454044
40MP0009764_decreased_sensitivity_to1.55491530
41MP0010094_abnormal_chromosome_stability1.54064914
42MP0001533_abnormal_skeleton_physiology1.51136064
43MP0005670_abnormal_white_adipose1.50573522
44MP0000767_abnormal_smooth_muscle1.50276613
45MP0002933_joint_inflammation1.47508622
46MP0005623_abnormal_meninges_morphology1.44141541
47MP0006082_CNS_inflammation1.43156147
48MP0001835_abnormal_antigen_presentation1.42696762
49MP0005023_abnormal_wound_healing1.41222241
50MP0005164_abnormal_response_to1.35969174
51MP0003011_delayed_dark_adaptation1.33139988
52MP0002060_abnormal_skin_morphology1.32967548
53MP0004272_abnormal_basement_membrane1.26174445
54MP0008995_early_reproductive_senescence1.26071855
55MP0005647_abnormal_sex_gland1.25451386
56MP0003303_peritoneal_inflammation1.25420745
57MP0009250_abnormal_appendicular_skeleto1.25408335
58MP0005025_abnormal_response_to1.23360955
59MP0005423_abnormal_somatic_nervous1.23227629
60MP0005595_abnormal_vascular_smooth1.21294190
61MP0002896_abnormal_bone_mineralization1.20978330
62MP0002148_abnormal_hypersensitivity_rea1.20641884
63MP0001879_abnormal_lymphatic_vessel1.13683364
64MP0005409_darkened_coat_color1.11290530
65MP0005257_abnormal_intraocular_pressure1.09922520
66MP0003795_abnormal_bone_structure1.09552986
67MP0003656_abnormal_erythrocyte_physiolo1.09045775
68MP0008007_abnormal_cellular_replicative1.05651153
69MP0000681_abnormal_thyroid_gland1.03901400
70MP0005000_abnormal_immune_tolerance1.03609342
71MP0005389_reproductive_system_phenotype1.03432915
72MP0000343_altered_response_to1.03266184
73MP0009765_abnormal_xenobiotic_induced1.02196506
74MP0002113_abnormal_skeleton_development1.00340083
75MP0000604_amyloidosis0.99520247
76MP0003786_premature_aging0.97739464
77MP0006036_abnormal_mitochondrial_physio0.96212954
78MP0004233_abnormal_muscle_weight0.95009898
79MP0004883_abnormal_blood_vessel0.93297103
80MP0002420_abnormal_adaptive_immunity0.93184401
81MP0001819_abnormal_immune_cell0.91536949
82MP0003191_abnormal_cellular_cholesterol0.91518894
83MP0004808_abnormal_hematopoietic_stem0.90965120
84MP0003566_abnormal_cell_adhesion0.90524101
85MP0003115_abnormal_respiratory_system0.89388964
86MP0003111_abnormal_nucleus_morphology0.89354783
87MP0003448_altered_tumor_morphology0.89257530
88MP0003300_gastrointestinal_ulcer0.88534272
89MP0004947_skin_inflammation0.87803890
90MP0005165_increased_susceptibility_to0.84781506
91MP0001765_abnormal_ion_homeostasis0.84546288
92MP0002452_abnormal_antigen_presenting0.83158754
93MP0009046_muscle_twitch0.83150242
94MP0001915_intracranial_hemorrhage0.82798234
95MP0003045_fibrosis0.82197592
96MP0002822_catalepsy0.81978874
97MP0002295_abnormal_pulmonary_circulatio0.80382343
98MP0002398_abnormal_bone_marrow0.79733463
99MP0004858_abnormal_nervous_system0.78879179
100MP0001984_abnormal_olfaction0.78273890
101MP0002877_abnormal_melanocyte_morpholog0.77948107
102MP0004185_abnormal_adipocyte_glucose0.77614582
103MP0000733_abnormal_muscle_development0.76448562
104MP0004510_myositis0.76159867
105MP0000858_altered_metastatic_potential0.75698857
106MP0000249_abnormal_blood_vessel0.74285805
107MP0002115_abnormal_skeleton_extremities0.74269227
108MP0000569_abnormal_digit_pigmentation0.73763704
109MP0005451_abnormal_body_composition0.73713440
110MP0002932_abnormal_joint_morphology0.73696154
111MP0002009_preneoplasia0.72772853
112MP0000759_abnormal_skeletal_muscle0.72435191
113MP0003075_altered_response_to0.71822824
114MP0003693_abnormal_embryo_hatching0.71421853
115MP0009785_altered_susceptibility_to0.71143930
116MP0000358_abnormal_cell_content/0.70625546
117MP0002723_abnormal_immune_serum0.70356541
118MP0003787_abnormal_imprinting0.68051506
119MP0000716_abnormal_immune_system0.66702162
120MP0002102_abnormal_ear_morphology0.65894292
121MP0001243_abnormal_dermal_layer0.65785446
122MP0002429_abnormal_blood_cell0.65620406
123MP0000163_abnormal_cartilage_morphology0.65368964
124MP0008469_abnormal_protein_level0.65169677
125MP0002234_abnormal_pharynx_morphology0.64072460
126MP0000749_muscle_degeneration0.61498526
127MP0003077_abnormal_cell_cycle0.60581178
128MP0001545_abnormal_hematopoietic_system0.60481181
129MP0005397_hematopoietic_system_phenotyp0.60481181
130MP0003315_abnormal_perineum_morphology0.59885433
131MP0003699_abnormal_female_reproductive0.58994536
132MP0004036_abnormal_muscle_relaxation0.58352270
133MP0006035_abnormal_mitochondrial_morpho0.57992174
134MP0005174_abnormal_tail_pigmentation0.57801234
135MP0001119_abnormal_female_reproductive0.57746062
136MP0001293_anophthalmia0.57407059
137MP0002269_muscular_atrophy0.51239282
138MP0001324_abnormal_eye_pigmentation0.48475727
139MP0006138_congestive_heart_failure0.47905011
140MP0001730_embryonic_growth_arrest0.46659493
141MP0000313_abnormal_cell_death0.39564080
142MP0010307_abnormal_tumor_latency0.39354965
143MP0005253_abnormal_eye_physiology0.39177129
144MP0001764_abnormal_homeostasis0.38508764
145MP0005551_abnormal_eye_electrophysiolog0.38484046
146MP0000751_myopathy0.38399941
147MP0004019_abnormal_vitamin_homeostasis0.38158554
148MP0005377_hearing/vestibular/ear_phenot0.37488240
149MP0003878_abnormal_ear_physiology0.37488240
150MP0005636_abnormal_mineral_homeostasis0.37091403
151MP0005391_vision/eye_phenotype0.32967117
152MP0000015_abnormal_ear_pigmentation0.30936059
153MP0004134_abnormal_chest_morphology0.30555673
154MP0002928_abnormal_bile_duct0.28623268
155MP0001986_abnormal_taste_sensitivity0.28216265
156MP0003950_abnormal_plasma_membrane0.28033128
157MP0001697_abnormal_embryo_size0.27681985
158MP0002132_abnormal_respiratory_system0.27471802
159MP0003122_maternal_imprinting0.26266820
160MP0005075_abnormal_melanosome_morpholog0.25863695
161MP0003942_abnormal_urinary_system0.25516632
162MP0010630_abnormal_cardiac_muscle0.25510251
163MP0004087_abnormal_muscle_fiber0.25445409
164MP0002084_abnormal_developmental_patter0.25362879
165MP0002736_abnormal_nociception_after0.25065702
166MP0002133_abnormal_respiratory_system0.24097459
167MP0005388_respiratory_system_phenotype0.24097459
168MP0004957_abnormal_blastocyst_morpholog0.23269536
169MP0005380_embryogenesis_phenotype0.23107763
170MP0001672_abnormal_embryogenesis/_devel0.23107763
171MP0004084_abnormal_cardiac_muscle0.22581150
172MP0002405_respiratory_system_inflammati0.22461518
173MP0002080_prenatal_lethality0.21752470
174MP0002139_abnormal_hepatobiliary_system0.21662388
175MP0009697_abnormal_copulation0.21655097
176MP0003861_abnormal_nervous_system0.21252075
177MP0009115_abnormal_fat_cell0.20792824
178MP0000537_abnormal_urethra_morphology0.20514656
179MP0001727_abnormal_embryo_implantation0.19484645
180MP0002092_abnormal_eye_morphology0.19410747
181MP0004145_abnormal_muscle_electrophysio0.19005408
182MP0008961_abnormal_basal_metabolism0.18924765
183MP0008932_abnormal_embryonic_tissue0.18908051
184MP0002106_abnormal_muscle_physiology0.18907103
185MP0003984_embryonic_growth_retardation0.18731303
186MP0000534_abnormal_ureter_morphology0.18721497
187MP0002088_abnormal_embryonic_growth/wei0.18568706
188MP0003879_abnormal_hair_cell0.18540042

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.22688267
2Abnormal respiratory epithelium morphology (HP:0012253)8.89404381
3Abnormal respiratory motile cilium morphology (HP:0005938)8.89404381
4Rhinitis (HP:0012384)8.14678651
5Chronic bronchitis (HP:0004469)7.36496971
6Abnormal ciliary motility (HP:0012262)7.30518876
7Infertility (HP:0000789)6.46436496
8Nasal polyposis (HP:0100582)6.24460066
9Abnormality of the nasal mucosa (HP:0000433)5.26209335
10Bronchiectasis (HP:0002110)4.58213570
11Bronchitis (HP:0012387)4.52409008
12Nephronophthisis (HP:0000090)4.51864434
13Premature rupture of membranes (HP:0001788)4.36888781
14Spondylolisthesis (HP:0003302)4.30518257
15Protrusio acetabuli (HP:0003179)4.17924282
16Ankle contracture (HP:0006466)3.92950954
17Follicular hyperkeratosis (HP:0007502)3.86674430
18Autoimmune thrombocytopenia (HP:0001973)3.64467868
19Gonadotropin excess (HP:0000837)3.63724251
20Metaphyseal dysplasia (HP:0100255)3.57927712
21Thrombocytosis (HP:0001894)3.48055291
22Recurrent sinusitis (HP:0011108)3.46849481
23Slender build (HP:0001533)3.36810721
24Abnormality of the renal medulla (HP:0100957)3.35801857
25Syringomyelia (HP:0003396)3.29676953
26Spinal cord lesions (HP:0100561)3.29676953
27Abnormality of the lower motor neuron (HP:0002366)3.29441730
28Type 1 muscle fiber predominance (HP:0003803)3.28500417
29Male infertility (HP:0003251)3.27616264
30Genu recurvatum (HP:0002816)3.19728707
31Acute lymphatic leukemia (HP:0006721)3.18841638
32Recurrent otitis media (HP:0000403)3.18633107
33Increased variability in muscle fiber diameter (HP:0003557)3.18481367
34Abnormal spermatogenesis (HP:0008669)3.13231628
35Hand muscle atrophy (HP:0009130)3.12565700
36Achilles tendon contracture (HP:0001771)3.08982061
37Elevated erythrocyte sedimentation rate (HP:0003565)2.94022444
38Overgrowth (HP:0001548)2.93434484
39Joint stiffness (HP:0001387)2.93289338
40Abnormality of skeletal muscle fiber size (HP:0012084)2.92414575
41Hypoventilation (HP:0002791)2.89652862
42Upper limb amyotrophy (HP:0009129)2.87795902
43Distal upper limb amyotrophy (HP:0007149)2.87795902
44Cervical subluxation (HP:0003308)2.86981179
45Spinal rigidity (HP:0003306)2.82839251
46Dysostosis multiplex (HP:0000943)2.82790011
47Thoracolumbar scoliosis (HP:0002944)2.82248712
48Acute myeloid leukemia (HP:0004808)2.78811217
49Epiphyseal dysplasia (HP:0002656)2.71447066
50Medial flaring of the eyebrow (HP:0010747)2.70563524
51Tubular atrophy (HP:0000092)2.68313536
52Tubulointerstitial nephritis (HP:0001970)2.67758399
53Amyotrophic lateral sclerosis (HP:0007354)2.65632184
54Aortic aneurysm (HP:0004942)2.63388787
55Recurrent bronchitis (HP:0002837)2.63017033
56Abnormality of midbrain morphology (HP:0002418)2.60878100
57Molar tooth sign on MRI (HP:0002419)2.60878100
58Abnormality of the Achilles tendon (HP:0005109)2.58389550
59Vertebral compression fractures (HP:0002953)2.57895548
60Autoimmune hemolytic anemia (HP:0001890)2.56746480
61Myocardial infarction (HP:0001658)2.55267270
62Thoracic kyphosis (HP:0002942)2.53854754
63Granulocytopenia (HP:0001913)2.52545220
64Tubulointerstitial abnormality (HP:0001969)2.51357271
65Flared iliac wings (HP:0002869)2.51025050
66Amyloidosis (HP:0011034)2.50178735
67Abnormality of glycolipid metabolism (HP:0010969)2.49857888
68Abnormality of liposaccharide metabolism (HP:0010968)2.49857888
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.49857888
70Amaurosis fugax (HP:0100576)2.43933040
71Impulsivity (HP:0100710)2.41285861
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.40013344
73Fibular hypoplasia (HP:0003038)2.36245636
74Blue sclerae (HP:0000592)2.35448900
75Thin bony cortex (HP:0002753)2.34472741
76Azoospermia (HP:0000027)2.32900048
77Elbow flexion contracture (HP:0002987)2.30246622
78Aortic regurgitation (HP:0001659)2.28428627
79Wormian bones (HP:0002645)2.26874758
80Abnormality of the thoracic spine (HP:0100711)2.25480780
81Delayed closure of the anterior fontanelle (HP:0001476)2.23823567
82Abnormality of the odontoid process (HP:0003310)2.23010619
83Impaired proprioception (HP:0010831)2.21892255
84Mesomelia (HP:0003027)2.21189294
85Mildly elevated creatine phosphokinase (HP:0008180)2.19534360
86Postaxial foot polydactyly (HP:0001830)2.18347674
87Aortic dissection (HP:0002647)2.17849749
88Tubulointerstitial fibrosis (HP:0005576)2.17433293
89Abnormality of polysaccharide metabolism (HP:0011012)2.14801078
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14801078
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14801078
92Short middle phalanx of the 5th finger (HP:0004220)2.13169376
93Soft skin (HP:0000977)2.12447816
94Abnormal drinking behavior (HP:0030082)2.07846871
95Polydipsia (HP:0001959)2.07846871
96Abnormality of B cell number (HP:0010975)2.07540327
97Hypoplasia of the capital femoral epiphysis (HP:0003090)2.06687899
98Cerebral aneurysm (HP:0004944)2.06621291
99Recurrent abscess formation (HP:0002722)2.06547651
100Dilatation of the ascending aorta (HP:0005111)2.04586420
101Abnormality of the acetabulum (HP:0003170)2.01772596
102Increased connective tissue (HP:0009025)2.00652727
103Abnormal platelet function (HP:0011869)2.00185270
104Impaired platelet aggregation (HP:0003540)2.00185270
105Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2295154
106Dynein arm defect of respiratory motile cilia (HP:0012255)12.6949782
107Absent/shortened dynein arms (HP:0200106)12.6949782
108Prostate neoplasm (HP:0100787)1.99523642
109Eosinophilia (HP:0001880)1.98681259
110Mitral regurgitation (HP:0001653)1.98068228
111Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.97874871
112Mucopolysacchariduria (HP:0008155)1.96540587
113Urinary glycosaminoglycan excretion (HP:0003541)1.96540587
114Obstructive sleep apnea (HP:0002870)1.96479151
115Upper motor neuron abnormality (HP:0002127)1.96187485
116Nuclear cataract (HP:0100018)1.95664535
117Ovoid vertebral bodies (HP:0003300)1.95387483
118Generalized amyotrophy (HP:0003700)1.94273114
119Broad metatarsal (HP:0001783)1.92878261
120Torticollis (HP:0000473)1.90520150
121Stage 5 chronic kidney disease (HP:0003774)1.89754690
122Supernumerary spleens (HP:0009799)1.89288197
123Bladder diverticulum (HP:0000015)1.89236935
124Narrow palate (HP:0000189)1.89169429
125Broad ribs (HP:0000885)1.88964664
126Fatigue (HP:0012378)1.88074092
127Abnormality of the renal cortex (HP:0011035)1.87773018
128Hypergammaglobulinemia (HP:0010702)1.87448727
129Cupped ribs (HP:0000887)1.87108604
130Peritonitis (HP:0002586)1.86955995
131Short ribs (HP:0000773)1.85619804
132Recurrent cutaneous fungal infections (HP:0011370)1.85247688
133Chronic mucocutaneous candidiasis (HP:0002728)1.85247688
134Congenital hepatic fibrosis (HP:0002612)1.84585369
135Microglossia (HP:0000171)1.83410322
136Short nail (HP:0001799)1.83408022
137Joint laxity (HP:0001388)1.82923838
138Neonatal hypoglycemia (HP:0001998)1.82893250
139Atrophic scars (HP:0001075)1.82596645
140Supranuclear gaze palsy (HP:0000605)1.81914520
141Hypoplasia of the odontoid process (HP:0003311)1.81874996
142Facial cleft (HP:0002006)1.81205736
143Cardiovascular calcification (HP:0011915)1.80249810
144Absent frontal sinuses (HP:0002688)1.78456078
14511 pairs of ribs (HP:0000878)1.76935414
146Renal dysplasia (HP:0000110)1.72551402
147Oculomotor apraxia (HP:0000657)1.66642640
148Abnormal gallbladder physiology (HP:0012438)1.65727066
149Cholecystitis (HP:0001082)1.65727066
150Congenital primary aphakia (HP:0007707)1.64295899
151Postaxial hand polydactyly (HP:0001162)1.62184672
152Abnormality of renal excretion (HP:0011036)1.61448142
153Abnormality of dentin (HP:0010299)1.60891988
154Gait imbalance (HP:0002141)1.60327009
155Absent epiphyses (HP:0010577)1.59946612
156Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59946612
157Degeneration of anterior horn cells (HP:0002398)1.58877056
158Abnormality of the anterior horn cell (HP:0006802)1.58877056
159Abnormality of permanent molar morphology (HP:0011071)1.55928941
160Abnormality of the dental root (HP:0006486)1.55928941
161Taurodontia (HP:0000679)1.55928941
162Chronic sinusitis (HP:0011109)1.55590247
163Bell-shaped thorax (HP:0001591)1.48757146
164J-shaped sella turcica (HP:0002680)1.47982227
165Short thorax (HP:0010306)1.46619562
166Spastic tetraparesis (HP:0001285)1.46150484
167Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.45658687
168Abnormality of molar morphology (HP:0011070)1.43708166
169Abnormality of molar (HP:0011077)1.43708166
170Breast carcinoma (HP:0003002)1.39713313
171Nephrogenic diabetes insipidus (HP:0009806)1.39666909
172Abnormality of the dental pulp (HP:0006479)1.39001432
173Dyschromatopsia (HP:0007641)1.38882460
174Aplasia/Hypoplasia of the tongue (HP:0010295)1.37316345
175Aplasia/Hypoplasia of the lens (HP:0008063)1.36220648
176Cerebellar dysplasia (HP:0007033)1.35193240
177Aplasia/Hypoplasia of the fibula (HP:0006492)1.33088473
178Heterotopia (HP:0002282)1.32237171
179Abnormality of ocular smooth pursuit (HP:0000617)1.30985718
180Choroideremia (HP:0001139)1.30772279
181Abnormal urine output (HP:0012590)1.30173508
182Median cleft lip (HP:0000161)1.30067806
183Broad distal phalanx of finger (HP:0009836)1.28450379
184Cystic liver disease (HP:0006706)1.27649110
185Poor coordination (HP:0002370)1.26684439
186Pancreatic fibrosis (HP:0100732)1.26527783
187Nephropathy (HP:0000112)1.25434508
188Decreased central vision (HP:0007663)1.25030838
189Bile duct proliferation (HP:0001408)1.23028027
190Abnormal biliary tract physiology (HP:0012439)1.23028027
191Polyuria (HP:0000103)1.22933487
192Gaze-evoked nystagmus (HP:0000640)1.20938655
193Short femoral neck (HP:0100864)1.19503369
194Pachygyria (HP:0001302)1.17662210
195Easy fatigability (HP:0003388)1.17594146
196Nephroblastoma (Wilms tumor) (HP:0002667)1.16843081

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.70151528
2PDK38.70151528
3PDK25.51735609
4TESK15.31637901
5PRKD34.05574728
6FLT33.91592784
7KIT3.64820330
8ICK3.32090617
9MOS3.22205815
10NME22.83528624
11IRAK32.56231099
12PTK2B2.39625474
13MAP3K62.30840558
14NEK22.26789252
15WNK42.08724384
16TGFBR22.05123454
17STK392.02482665
18ABL21.94343958
19PRPF4B1.82430454
20PNCK1.82144082
21FES1.81754639
22CAMK1D1.77116475
23TEC1.76122623
24TRPM71.73277587
25DDR21.71868653
26RIPK41.64413948
27MAP2K31.62258398
28STK381.60372040
29NEK91.53739757
30MAP3K131.49115416
31CCNB11.36714726
32RPS6KA21.36432679
33TBK11.33227807
34BTK1.31411256
35PDGFRA1.28360465
36PRKD21.27907106
37CDK61.24576032
38MAP3K141.22947639
39DYRK1B1.22671036
40PAK61.17383231
41PASK1.13251941
42DYRK31.10055793
43CDC71.10053687
44HIPK21.07901150
45TYK21.07011183
46MUSK1.05685461
47ERN11.05125434
48GRK71.03643022
49TAOK31.03382876
50SCYL21.02605856
51PKN21.02562160
52PDGFRB1.00428076
53GRK61.00388772
54GSK3A0.99922623
55PLK40.97870915
56STK30.97037599
57PTK20.96960136
58MAPK40.91001899
59PDK10.90645880
60MYLK0.87661147
61LIMK10.86734986
62RPS6KL10.86508121
63RPS6KC10.86508121
64MAPK150.85652797
65TTN0.85380019
66JAK30.85194170
67TNK20.84897934
68ARAF0.83349191
69IRAK10.82452439
70PIK3CG0.79183269
71BLK0.79030793
72WNK10.75707692
73TTK0.72095293
74RPS6KA60.70823799
75CHEK20.69484813
76STK38L0.66119233
77BRAF0.65307480
78SYK0.65052285
79PINK10.64421229
80ATR0.63639902
81TYRO30.60677496
82WEE10.59591927
83LCK0.58493947
84IKBKB0.57652830
85PIM20.57573330
86MAPK70.56889737
87HCK0.55905966
88CHEK10.54963631
89ABL10.54526718
90BRD40.51248931
91TAOK20.47871385
92IKBKE0.46845295
93MAP3K110.46750150
94MAPK120.46714553
95CDK120.46713266
96MAPK30.45691900
97BMPR1B0.45065715
98GRK50.44737764
99ATM0.44318049
100TIE10.43964170
101PRKD10.43768115
102PRKCD0.43604425
103KDR0.42346331
104MAP2K60.39946099
105ADRBK10.39250301
106BCKDK0.39033082
107LYN0.38664245
108CDC42BPA0.38573063
109BMPR20.37369495
110PLK10.37217672
111MKNK20.35395567
112JAK10.34142774
113CSK0.32640750
114TESK20.32085432
115PAK10.30649451
116PAK20.28772936
117NTRK20.27211211
118PDPK10.27204854
119ZAK0.25651431
120LMTK20.25488767
121STK160.24807337
122EEF2K0.24264148
123MARK20.23539430
124CSF1R0.23525743
125IRAK20.23110480
126PRKAA10.20852179
127PAK40.20630069
128TGFBR10.20347218
129CAMKK10.19812663
130CSNK2A10.18492871
131PRKG10.18400247
132MAP3K100.17673735
133MTOR0.17443845
134AKT30.16782195
135PRKCG0.16325736
136TNIK0.15607903
137PRKG20.15476294
138MARK30.15362513
139RPS6KB10.14626149
140NEK60.14164299
141BRSK20.13895290
142CDK40.11081098
143PRKACB0.10215658
144CDK20.10192169
145MAP2K70.09561546
146CDK10.08280719
147CSNK1D0.07736631
148CSNK2A20.07483055
149LATS20.07342741
150OBSCN0.06932936
151ZAP700.05763018
152AURKB0.05081868
153CAMK1G0.04485736
154GSK3B0.04171767
155PRKACG0.04163871
156MAP3K40.03580032
157PRKCQ0.02569681
158RPS6KA10.02566451
159PRKDC0.02542103
160AURKA0.02506912
161MAPK80.02182884
162PIM10.01936502
163CDK70.01916774
164MAPKAPK50.01414256
165CDK150.01385752
166BUB10.01206533
167CDK30.01204484
168BRSK10.01120139
169CDK11A0.00903421
170YES10.00466992
171EGFR-0.0050483
172CDK18-0.0044262
173TRIB3-0.0018375
174PRKCB-0.0001142

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.33582314
2Pyruvate metabolism_Homo sapiens_hsa006204.20465669
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.03597912
4Other glycan degradation_Homo sapiens_hsa005113.74638009
5Basal transcription factors_Homo sapiens_hsa030223.37519874
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.37023382
7Propanoate metabolism_Homo sapiens_hsa006403.20684443
8Glucagon signaling pathway_Homo sapiens_hsa049222.81352544
9Fatty acid biosynthesis_Homo sapiens_hsa000612.78263972
10Fanconi anemia pathway_Homo sapiens_hsa034602.64435139
11Selenocompound metabolism_Homo sapiens_hsa004502.49515188
12Pentose phosphate pathway_Homo sapiens_hsa000302.38279721
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.37556680
14Huntingtons disease_Homo sapiens_hsa050162.35845406
15Linoleic acid metabolism_Homo sapiens_hsa005912.34102475
16Oocyte meiosis_Homo sapiens_hsa041142.32414863
17Cardiac muscle contraction_Homo sapiens_hsa042602.06446405
18Malaria_Homo sapiens_hsa051442.04667996
19Acute myeloid leukemia_Homo sapiens_hsa052211.94913501
20ECM-receptor interaction_Homo sapiens_hsa045121.83042951
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.78982877
22RNA transport_Homo sapiens_hsa030131.78833151
23Dorso-ventral axis formation_Homo sapiens_hsa043201.74013265
24Glycerolipid metabolism_Homo sapiens_hsa005611.71885323
25mRNA surveillance pathway_Homo sapiens_hsa030151.71118381
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.70791156
27Osteoclast differentiation_Homo sapiens_hsa043801.70594485
28Focal adhesion_Homo sapiens_hsa045101.69657648
29Amoebiasis_Homo sapiens_hsa051461.66867511
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64835294
31Amphetamine addiction_Homo sapiens_hsa050311.59752240
32Lysosome_Homo sapiens_hsa041421.58213695
33TNF signaling pathway_Homo sapiens_hsa046681.54447641
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51509051
35Leishmaniasis_Homo sapiens_hsa051401.51227778
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.49849086
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.45551290
38Shigellosis_Homo sapiens_hsa051311.43253365
39Chronic myeloid leukemia_Homo sapiens_hsa052201.41166594
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39026390
41Bladder cancer_Homo sapiens_hsa052191.36737609
42Carbon metabolism_Homo sapiens_hsa012001.36463208
43Pertussis_Homo sapiens_hsa051331.35795080
44PPAR signaling pathway_Homo sapiens_hsa033201.32799136
45Salmonella infection_Homo sapiens_hsa051321.30611746
46Renin-angiotensin system_Homo sapiens_hsa046141.29668312
47Purine metabolism_Homo sapiens_hsa002301.28669678
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28110078
49Hepatitis B_Homo sapiens_hsa051611.27489312
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27195549
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.26735279
52Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26431195
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26036242
54Pancreatic cancer_Homo sapiens_hsa052121.25934758
55Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23559098
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22296742
57Fructose and mannose metabolism_Homo sapiens_hsa000511.22182693
58Platelet activation_Homo sapiens_hsa046111.20829883
59Rheumatoid arthritis_Homo sapiens_hsa053231.19974088
60Renin secretion_Homo sapiens_hsa049241.16243496
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15379285
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15297661
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15021104
64GnRH signaling pathway_Homo sapiens_hsa049121.14944319
65Neurotrophin signaling pathway_Homo sapiens_hsa047221.14912620
66Glutathione metabolism_Homo sapiens_hsa004801.14094876
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13022516
68Phospholipase D signaling pathway_Homo sapiens_hsa040721.12540468
69Hematopoietic cell lineage_Homo sapiens_hsa046401.11755711
70African trypanosomiasis_Homo sapiens_hsa051431.11644325
71Homologous recombination_Homo sapiens_hsa034401.09764235
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06379087
73Tuberculosis_Homo sapiens_hsa051521.05280852
74Melanoma_Homo sapiens_hsa052181.05112340
75DNA replication_Homo sapiens_hsa030301.05018954
76Proteoglycans in cancer_Homo sapiens_hsa052051.04886481
77Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04520244
78Notch signaling pathway_Homo sapiens_hsa043301.00314104
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99273386
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.98807858
81Ether lipid metabolism_Homo sapiens_hsa005650.97830698
82MicroRNAs in cancer_Homo sapiens_hsa052060.97739419
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97250665
84Non-homologous end-joining_Homo sapiens_hsa034500.96079300
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.94966238
86RNA degradation_Homo sapiens_hsa030180.94478375
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94461100
88MAPK signaling pathway_Homo sapiens_hsa040100.94446586
89Dilated cardiomyopathy_Homo sapiens_hsa054140.92330248
90Phagosome_Homo sapiens_hsa041450.91572320
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90775370
92Biosynthesis of amino acids_Homo sapiens_hsa012300.90084729
93Antigen processing and presentation_Homo sapiens_hsa046120.89891710
94Pyrimidine metabolism_Homo sapiens_hsa002400.89012751
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87831381
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86897609
97Non-small cell lung cancer_Homo sapiens_hsa052230.86427845
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84638442
99Influenza A_Homo sapiens_hsa051640.84193107
100Base excision repair_Homo sapiens_hsa034100.81168976
101Arachidonic acid metabolism_Homo sapiens_hsa005900.80299160
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.79465124
103Renal cell carcinoma_Homo sapiens_hsa052110.78642253
104Choline metabolism in cancer_Homo sapiens_hsa052310.77844371
105Chemokine signaling pathway_Homo sapiens_hsa040620.77550637
106Fat digestion and absorption_Homo sapiens_hsa049750.77546152
107N-Glycan biosynthesis_Homo sapiens_hsa005100.76543429
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75986310
109Proteasome_Homo sapiens_hsa030500.75457903
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74628813
111Apoptosis_Homo sapiens_hsa042100.74158213
112Parkinsons disease_Homo sapiens_hsa050120.73871660
113Cell cycle_Homo sapiens_hsa041100.73311440
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73178518
115Long-term potentiation_Homo sapiens_hsa047200.72291362
116Pathways in cancer_Homo sapiens_hsa052000.72267794
117Protein digestion and absorption_Homo sapiens_hsa049740.72246926
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70309930
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69225910
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68433159
121Asthma_Homo sapiens_hsa053100.68113471
122Chemical carcinogenesis_Homo sapiens_hsa052040.67946575
123Ras signaling pathway_Homo sapiens_hsa040140.67606548
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67424266
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.66190264
126Fatty acid metabolism_Homo sapiens_hsa012120.65810915
127Toxoplasmosis_Homo sapiens_hsa051450.65772933
128Colorectal cancer_Homo sapiens_hsa052100.65476136
129Fatty acid degradation_Homo sapiens_hsa000710.65046655
130Hedgehog signaling pathway_Homo sapiens_hsa043400.64382593
131Long-term depression_Homo sapiens_hsa047300.64300152
132Glioma_Homo sapiens_hsa052140.63596414
133Calcium signaling pathway_Homo sapiens_hsa040200.63212889
134Spliceosome_Homo sapiens_hsa030400.63079528
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62258196
136Rap1 signaling pathway_Homo sapiens_hsa040150.62225888
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62085807
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61908631
139Systemic lupus erythematosus_Homo sapiens_hsa053220.61802383
140Prolactin signaling pathway_Homo sapiens_hsa049170.60773906
141Alzheimers disease_Homo sapiens_hsa050100.59268079
142Oxidative phosphorylation_Homo sapiens_hsa001900.59012158
143mTOR signaling pathway_Homo sapiens_hsa041500.58405460
144ErbB signaling pathway_Homo sapiens_hsa040120.57785474
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.56390685
146Mineral absorption_Homo sapiens_hsa049780.53983134
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52356485
148NF-kappa B signaling pathway_Homo sapiens_hsa040640.51738491
149Oxytocin signaling pathway_Homo sapiens_hsa049210.50052624
150T cell receptor signaling pathway_Homo sapiens_hsa046600.49918442
151Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49842284
152ABC transporters_Homo sapiens_hsa020100.49011941
153Gap junction_Homo sapiens_hsa045400.48441916
154Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48123819
155Mismatch repair_Homo sapiens_hsa034300.47748260
156Cocaine addiction_Homo sapiens_hsa050300.47584036
157Herpes simplex infection_Homo sapiens_hsa051680.47507081
158Estrogen signaling pathway_Homo sapiens_hsa049150.46844636
159Nucleotide excision repair_Homo sapiens_hsa034200.46730750
160Sphingolipid metabolism_Homo sapiens_hsa006000.45688475
161Measles_Homo sapiens_hsa051620.45208952
162Collecting duct acid secretion_Homo sapiens_hsa049660.44826252
163Metabolic pathways_Homo sapiens_hsa011000.44809735
164Wnt signaling pathway_Homo sapiens_hsa043100.40831813
165B cell receptor signaling pathway_Homo sapiens_hsa046620.39256586
166Circadian entrainment_Homo sapiens_hsa047130.39083152
167Legionellosis_Homo sapiens_hsa051340.38858118
168Vascular smooth muscle contraction_Homo sapiens_hsa042700.38623705
169AMPK signaling pathway_Homo sapiens_hsa041520.36625309
170Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34205896
171VEGF signaling pathway_Homo sapiens_hsa043700.32575317
172Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31647229
173Insulin secretion_Homo sapiens_hsa049110.30132344
174Viral carcinogenesis_Homo sapiens_hsa052030.29222041
175Epstein-Barr virus infection_Homo sapiens_hsa051690.27745941
176Adipocytokine signaling pathway_Homo sapiens_hsa049200.27644768
177Thyroid hormone synthesis_Homo sapiens_hsa049180.26521592
178Basal cell carcinoma_Homo sapiens_hsa052170.25119543
179Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24886826
180Endocytosis_Homo sapiens_hsa041440.24863084
181Alcoholism_Homo sapiens_hsa050340.24457295
182HTLV-I infection_Homo sapiens_hsa051660.21141735
183Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19729723
184Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15792537
185cAMP signaling pathway_Homo sapiens_hsa040240.15782363
186Inositol phosphate metabolism_Homo sapiens_hsa005620.15702386

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