

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 5.43968406 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.91732390 |
| 3 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.87676538 |
| 4 | locomotory exploration behavior (GO:0035641) | 4.56410847 |
| 5 | postsynaptic membrane organization (GO:0001941) | 4.40363891 |
| 6 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.31859436 |
| 7 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.21102788 |
| 8 | COPI coating of Golgi vesicle (GO:0048205) | 4.07550945 |
| 9 | Golgi transport vesicle coating (GO:0048200) | 4.07550945 |
| 10 | activation of protein kinase A activity (GO:0034199) | 3.94626431 |
| 11 | synaptic vesicle exocytosis (GO:0016079) | 3.86688458 |
| 12 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.84824897 |
| 13 | layer formation in cerebral cortex (GO:0021819) | 3.83428441 |
| 14 | regulation of synaptic vesicle transport (GO:1902803) | 3.81262834 |
| 15 | cerebellar Purkinje cell layer development (GO:0021680) | 3.71480534 |
| 16 | presynaptic membrane organization (GO:0097090) | 3.65354797 |
| 17 | presynaptic membrane assembly (GO:0097105) | 3.59392047 |
| 18 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.54151645 |
| 19 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.53966478 |
| 20 | neurotransmitter secretion (GO:0007269) | 3.49628930 |
| 21 | L-amino acid import (GO:0043092) | 3.48318521 |
| 22 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.48187329 |
| 23 | nucleobase catabolic process (GO:0046113) | 3.45970043 |
| 24 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.44863088 |
| 25 | response to pheromone (GO:0019236) | 3.42023347 |
| 26 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.41659210 |
| 27 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.34151057 |
| 28 | insulin secretion (GO:0030073) | 3.33678580 |
| 29 | regulation of synapse structural plasticity (GO:0051823) | 3.32620110 |
| 30 | cell migration in hindbrain (GO:0021535) | 3.30809800 |
| 31 | dendritic spine morphogenesis (GO:0060997) | 3.27947163 |
| 32 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.26735940 |
| 33 | regulation of ARF protein signal transduction (GO:0032012) | 3.26123984 |
| 34 | exploration behavior (GO:0035640) | 3.20499597 |
| 35 | glutamate secretion (GO:0014047) | 3.19872981 |
| 36 | establishment of mitochondrion localization (GO:0051654) | 3.16672878 |
| 37 | vocalization behavior (GO:0071625) | 3.15668785 |
| 38 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.15267830 |
| 39 | axonal fasciculation (GO:0007413) | 3.14755076 |
| 40 | cerebellar granule cell differentiation (GO:0021707) | 3.10806237 |
| 41 | proline transport (GO:0015824) | 3.08761208 |
| 42 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 3.06132435 |
| 43 | amino acid import (GO:0043090) | 3.05601626 |
| 44 | glutamate receptor signaling pathway (GO:0007215) | 3.03237049 |
| 45 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.03144263 |
| 46 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.01917426 |
| 47 | dendrite morphogenesis (GO:0048813) | 3.00132988 |
| 48 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 2.99820491 |
| 49 | neuronal ion channel clustering (GO:0045161) | 2.99110590 |
| 50 | neuron-neuron synaptic transmission (GO:0007270) | 2.98439013 |
| 51 | positive regulation of neurotransmitter transport (GO:0051590) | 2.98024562 |
| 52 | positive regulation of synapse maturation (GO:0090129) | 2.97880940 |
| 53 | neuromuscular process controlling posture (GO:0050884) | 2.96707997 |
| 54 | glycine transport (GO:0015816) | 2.96587723 |
| 55 | neuron recognition (GO:0008038) | 2.96123449 |
| 56 | nerve growth factor signaling pathway (GO:0038180) | 2.95678174 |
| 57 | vesicle transport along microtubule (GO:0047496) | 2.95342516 |
| 58 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.93448158 |
| 59 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.93312122 |
| 60 | cell communication by electrical coupling (GO:0010644) | 2.92599083 |
| 61 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.91206823 |
| 62 | axon ensheathment in central nervous system (GO:0032291) | 2.90695100 |
| 63 | central nervous system myelination (GO:0022010) | 2.90695100 |
| 64 | potassium ion homeostasis (GO:0055075) | 2.90550056 |
| 65 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.90521840 |
| 66 | neuron cell-cell adhesion (GO:0007158) | 2.90409217 |
| 67 | transmission of nerve impulse (GO:0019226) | 2.89598298 |
| 68 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.88788981 |
| 69 | positive regulation of dendritic spine development (GO:0060999) | 2.88718458 |
| 70 | auditory behavior (GO:0031223) | 2.87797383 |
| 71 | neuromuscular process controlling balance (GO:0050885) | 2.86690128 |
| 72 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.85607443 |
| 73 | cellular response to glucagon stimulus (GO:0071377) | 2.85458452 |
| 74 | suckling behavior (GO:0001967) | 2.84646300 |
| 75 | regulation of neurotransmitter transport (GO:0051588) | 2.84191886 |
| 76 | gamma-aminobutyric acid transport (GO:0015812) | 2.80961097 |
| 77 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.80202723 |
| 78 | adenosine receptor signaling pathway (GO:0001973) | 2.79767110 |
| 79 | sodium ion export (GO:0071436) | 2.78190326 |
| 80 | axon extension (GO:0048675) | 2.77500282 |
| 81 | dendritic spine organization (GO:0097061) | 2.77428441 |
| 82 | protein localization to synapse (GO:0035418) | 2.76950898 |
| 83 | regulation of postsynaptic membrane potential (GO:0060078) | 2.74764919 |
| 84 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.73831909 |
| 85 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.73805003 |
| 86 | mating behavior (GO:0007617) | 2.73114551 |
| 87 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 2.72287981 |
| 88 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 2.68861653 |
| 89 | neurotransmitter transport (GO:0006836) | 2.68773395 |
| 90 | response to auditory stimulus (GO:0010996) | 2.68508165 |
| 91 | cerebellum development (GO:0021549) | 2.68377545 |
| 92 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 2.65364821 |
| 93 | signal release (GO:0023061) | 2.64581949 |
| 94 | regulation of respiratory system process (GO:0044065) | 2.64091829 |
| 95 | type B pancreatic cell development (GO:0003323) | 2.63742845 |
| 96 | chemosensory behavior (GO:0007635) | 2.63441479 |
| 97 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.62897765 |
| 98 | mitochondrion transport along microtubule (GO:0047497) | 2.61264684 |
| 99 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.61264684 |
| 100 | regulation of vesicle fusion (GO:0031338) | 2.60869190 |
| 101 | regulation of exocytosis (GO:0017157) | 2.59556816 |
| 102 | regulation of beta-amyloid formation (GO:1902003) | 2.59381900 |
| 103 | neuromuscular process (GO:0050905) | 2.58805256 |
| 104 | positive regulation of exocytosis (GO:0045921) | 2.58002708 |
| 105 | regulation of synaptic plasticity (GO:0048167) | 2.57711614 |
| 106 | positive regulation of membrane potential (GO:0045838) | 2.57012577 |
| 107 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.56285057 |
| 108 | vesicle coating (GO:0006901) | 2.55276772 |
| 109 | establishment of nucleus localization (GO:0040023) | 2.54823363 |
| 110 | peptide hormone secretion (GO:0030072) | 2.54250405 |
| 111 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.53837145 |
| 112 | adult walking behavior (GO:0007628) | 2.53798389 |
| 113 | synapse assembly (GO:0007416) | 2.53696311 |
| 114 | synaptic vesicle endocytosis (GO:0048488) | 2.53443911 |
| 115 | axon cargo transport (GO:0008088) | 2.53421927 |
| 116 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.53081162 |
| 117 | prepulse inhibition (GO:0060134) | 2.53052684 |
| 118 | regulation of insulin secretion (GO:0050796) | 2.52893650 |
| 119 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.52694681 |
| 120 | long-term memory (GO:0007616) | 2.52422185 |
| 121 | membrane depolarization (GO:0051899) | 2.50914521 |
| 122 | membrane depolarization during action potential (GO:0086010) | 2.49816191 |
| 123 | cellular potassium ion homeostasis (GO:0030007) | 2.49726646 |
| 124 | endocrine pancreas development (GO:0031018) | 2.49654789 |
| 125 | negative regulation of axonogenesis (GO:0050771) | 2.49231789 |
| 126 | embryonic retina morphogenesis in camera-type eye (GO:0060059) | 2.48886373 |
| 127 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235 | 2.48628435 |
| 128 | clathrin coat assembly (GO:0048268) | 2.48564165 |
| 129 | positive regulation of insulin secretion (GO:0032024) | 2.48304393 |
| 130 | organelle transport along microtubule (GO:0072384) | 2.47547990 |
| 131 | positive regulation of synapse assembly (GO:0051965) | 2.47514515 |
| 132 | neuronal action potential propagation (GO:0019227) | 2.46702239 |
| 133 | peptide secretion (GO:0002790) | 2.46665252 |
| 134 | potassium ion import (GO:0010107) | 2.46414273 |
| 135 | innervation (GO:0060384) | 2.43556314 |
| 136 | synaptic transmission, glutamatergic (GO:0035249) | 2.41836164 |
| 137 | stress granule assembly (GO:0034063) | 2.41003569 |
| 138 | regulation of neurotransmitter levels (GO:0001505) | 2.40564825 |
| 139 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 2.40419651 |
| 140 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.39393633 |
| 141 | activation of signaling protein activity involved in unfolded protein response (GO:0006987) | 2.38855723 |
| 142 | regulation of neurotransmitter secretion (GO:0046928) | 2.38647986 |
| 143 | dopamine receptor signaling pathway (GO:0007212) | 2.38236993 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.14284003 |
| 2 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.58307301 |
| 3 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.53041035 |
| 4 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.51827196 |
| 5 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.47086607 |
| 6 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.32146219 |
| 7 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.30089574 |
| 8 | * SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.29780563 |
| 9 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.29174362 |
| 10 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.20227323 |
| 11 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.18073278 |
| 12 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.17528656 |
| 13 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.16964368 |
| 14 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.16964368 |
| 15 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.16550571 |
| 16 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.16420794 |
| 17 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.10693871 |
| 18 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.09414753 |
| 19 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.08714134 |
| 20 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.06778965 |
| 21 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.04983726 |
| 22 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.04554748 |
| 23 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.03579958 |
| 24 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.00726762 |
| 25 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.97566899 |
| 26 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.94696783 |
| 27 | KDM2B_26808549_Chip-Seq_K562_Human | 1.72338983 |
| 28 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.71975707 |
| 29 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.70531261 |
| 30 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.68780532 |
| 31 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.66892043 |
| 32 | * EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.65860155 |
| 33 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.62508890 |
| 34 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.59114980 |
| 35 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.58721697 |
| 36 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.51496739 |
| 37 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.50236511 |
| 38 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.46096058 |
| 39 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.46060345 |
| 40 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.45414701 |
| 41 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.40624008 |
| 42 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.37922077 |
| 43 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.36053764 |
| 44 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.35588275 |
| 45 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.32961473 |
| 46 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.32933152 |
| 47 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.32473621 |
| 48 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.31124441 |
| 49 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.28243103 |
| 50 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.27948770 |
| 51 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.27936953 |
| 52 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.24374176 |
| 53 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.23842344 |
| 54 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.21568036 |
| 55 | AR_19668381_ChIP-Seq_PC3_Human | 1.21556792 |
| 56 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.20717841 |
| 57 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.20552784 |
| 58 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.19431338 |
| 59 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.18070399 |
| 60 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.17994318 |
| 61 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.16574520 |
| 62 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.15616799 |
| 63 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.12563826 |
| 64 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.11395820 |
| 65 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.10714305 |
| 66 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.10383295 |
| 67 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.09159539 |
| 68 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.07120856 |
| 69 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.07022512 |
| 70 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.05248681 |
| 71 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.05248681 |
| 72 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.04894105 |
| 73 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.04070456 |
| 74 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.03780330 |
| 75 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.03464143 |
| 76 | STAT3_23295773_ChIP-Seq_U87_Human | 1.01967155 |
| 77 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.00710023 |
| 78 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.00681019 |
| 79 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.99267558 |
| 80 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.98996520 |
| 81 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.98871386 |
| 82 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.98052970 |
| 83 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96124377 |
| 84 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.95031674 |
| 85 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.94963737 |
| 86 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.94931020 |
| 87 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.94833784 |
| 88 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.92649931 |
| 89 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.92520117 |
| 90 | SPI1_23127762_ChIP-Seq_K562_Human | 0.91639740 |
| 91 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.90566871 |
| 92 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.90184200 |
| 93 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.89529039 |
| 94 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.89505417 |
| 95 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.88865325 |
| 96 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.88684874 |
| 97 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.88638337 |
| 98 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.88201228 |
| 99 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.88187646 |
| 100 | TP53_16413492_ChIP-PET_HCT116_Human | 0.88079174 |
| 101 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.87497137 |
| 102 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.86544789 |
| 103 | RXR_22108803_ChIP-Seq_LS180_Human | 0.86368167 |
| 104 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.86191155 |
| 105 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.86001029 |
| 106 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.85777170 |
| 107 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.85275782 |
| 108 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.84852780 |
| 109 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.81346237 |
| 110 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.81315598 |
| 111 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.81293960 |
| 112 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.81056112 |
| 113 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 0.80229364 |
| 114 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.80058974 |
| 115 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.79838311 |
| 116 | AR_25329375_ChIP-Seq_VCAP_Human | 0.79775528 |
| 117 | TCF4_23295773_ChIP-Seq_U87_Human | 0.79766863 |
| 118 | * TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.79110504 |
| 119 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.78389076 |
| 120 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.78363262 |
| 121 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.78301723 |
| 122 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.78220804 |
| 123 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.77698234 |
| 124 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.77018698 |
| 125 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.76131688 |
| 126 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.71919963 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 4.85209999 |
| 2 | MP0002909_abnormal_adrenal_gland | 3.50876998 |
| 3 | MP0003283_abnormal_digestive_organ | 3.40461936 |
| 4 | MP0009780_abnormal_chondrocyte_physiolo | 3.16870168 |
| 5 | MP0003635_abnormal_synaptic_transmissio | 3.06201127 |
| 6 | MP0003122_maternal_imprinting | 3.02175258 |
| 7 | MP0004270_analgesia | 2.89242859 |
| 8 | MP0005645_abnormal_hypothalamus_physiol | 2.72004955 |
| 9 | MP0005423_abnormal_somatic_nervous | 2.51390522 |
| 10 | MP0000569_abnormal_digit_pigmentation | 2.47542324 |
| 11 | MP0002063_abnormal_learning/memory/cond | 2.43038385 |
| 12 | MP0008961_abnormal_basal_metabolism | 2.42945470 |
| 13 | MP0003880_abnormal_central_pattern | 2.41737972 |
| 14 | MP0002877_abnormal_melanocyte_morpholog | 2.40552827 |
| 15 | MP0000013_abnormal_adipose_tissue | 2.27084131 |
| 16 | MP0010386_abnormal_urinary_bladder | 2.24133655 |
| 17 | MP0009745_abnormal_behavioral_response | 2.23442581 |
| 18 | MP0003787_abnormal_imprinting | 2.17767049 |
| 19 | MP0002064_seizures | 2.16406845 |
| 20 | MP0005646_abnormal_pituitary_gland | 2.11165374 |
| 21 | MP0002822_catalepsy | 2.03211936 |
| 22 | MP0002693_abnormal_pancreas_physiology | 2.02993001 |
| 23 | MP0002572_abnormal_emotion/affect_behav | 1.93384702 |
| 24 | MP0003879_abnormal_hair_cell | 1.92865362 |
| 25 | MP0001944_abnormal_pancreas_morphology | 1.84211461 |
| 26 | MP0003172_abnormal_lysosome_physiology | 1.84058706 |
| 27 | MP0002734_abnormal_mechanical_nocicepti | 1.78188423 |
| 28 | MP0004858_abnormal_nervous_system | 1.77198780 |
| 29 | MP0009046_muscle_twitch | 1.75114192 |
| 30 | MP0001486_abnormal_startle_reflex | 1.73335007 |
| 31 | MP0002733_abnormal_thermal_nociception | 1.72348120 |
| 32 | MP0004811_abnormal_neuron_physiology | 1.71143087 |
| 33 | MP0004043_abnormal_pH_regulation | 1.70531213 |
| 34 | MP0003183_abnormal_peptide_metabolism | 1.70341501 |
| 35 | MP0002272_abnormal_nervous_system | 1.65589745 |
| 36 | MP0000604_amyloidosis | 1.61313249 |
| 37 | MP0001501_abnormal_sleep_pattern | 1.59651056 |
| 38 | MP0001968_abnormal_touch/_nociception | 1.56066147 |
| 39 | MP0000778_abnormal_nervous_system | 1.52318638 |
| 40 | MP0000955_abnormal_spinal_cord | 1.51738542 |
| 41 | MP0002557_abnormal_social/conspecific_i | 1.49167164 |
| 42 | MP0001502_abnormal_circadian_rhythm | 1.48349904 |
| 43 | MP0005379_endocrine/exocrine_gland_phen | 1.47096192 |
| 44 | MP0000920_abnormal_myelination | 1.46945491 |
| 45 | MP0001970_abnormal_pain_threshold | 1.46175627 |
| 46 | MP0008569_lethality_at_weaning | 1.42217628 |
| 47 | MP0002184_abnormal_innervation | 1.40261154 |
| 48 | MP0004885_abnormal_endolymph | 1.32915139 |
| 49 | MP0003300_gastrointestinal_ulcer | 1.29132434 |
| 50 | MP0002638_abnormal_pupillary_reflex | 1.28881137 |
| 51 | MP0003121_genomic_imprinting | 1.28668369 |
| 52 | MP0000003_abnormal_adipose_tissue | 1.28367154 |
| 53 | MP0006276_abnormal_autonomic_nervous | 1.28277305 |
| 54 | MP0002067_abnormal_sensory_capabilities | 1.27222483 |
| 55 | MP0001984_abnormal_olfaction | 1.22622632 |
| 56 | MP0000631_abnormal_neuroendocrine_gland | 1.21781481 |
| 57 | MP0002078_abnormal_glucose_homeostasis | 1.19831424 |
| 58 | MP0004142_abnormal_muscle_tone | 1.17847644 |
| 59 | MP0002882_abnormal_neuron_morphology | 1.15978357 |
| 60 | MP0003329_amyloid_beta_deposits | 1.14646993 |
| 61 | MP0000678_abnormal_parathyroid_gland | 1.14058352 |
| 62 | MP0001963_abnormal_hearing_physiology | 1.13700645 |
| 63 | MP0003633_abnormal_nervous_system | 1.12783408 |
| 64 | MP0004924_abnormal_behavior | 1.10716219 |
| 65 | MP0005386_behavior/neurological_phenoty | 1.10716219 |
| 66 | MP0003632_abnormal_nervous_system | 1.10386298 |
| 67 | MP0003123_paternal_imprinting | 1.09125031 |
| 68 | MP0003303_peritoneal_inflammation | 1.06978573 |
| 69 | MP0002234_abnormal_pharynx_morphology | 1.05892242 |
| 70 | MP0002066_abnormal_motor_capabilities/c | 1.05875742 |
| 71 | MP0004742_abnormal_vestibular_system | 1.05796146 |
| 72 | MP0000026_abnormal_inner_ear | 1.04305919 |
| 73 | MP0001348_abnormal_lacrimal_gland | 1.04148099 |
| 74 | MP0001177_atelectasis | 1.04101610 |
| 75 | MP0004510_myositis | 1.03867537 |
| 76 | MP0002069_abnormal_eating/drinking_beha | 1.02931810 |
| 77 | MP0000534_abnormal_ureter_morphology | 1.01291543 |
| 78 | MP0000566_synostosis | 0.99389360 |
| 79 | MP0006072_abnormal_retinal_apoptosis | 0.98002488 |
| 80 | MP0005535_abnormal_body_temperature | 0.95495066 |
| 81 | MP0001440_abnormal_grooming_behavior | 0.95106598 |
| 82 | MP0001299_abnormal_eye_distance/ | 0.94112460 |
| 83 | MP0004133_heterotaxia | 0.93003621 |
| 84 | MP0005187_abnormal_penis_morphology | 0.92905041 |
| 85 | MP0003634_abnormal_glial_cell | 0.91360061 |
| 86 | MP0002653_abnormal_ependyma_morphology | 0.90355280 |
| 87 | MP0001905_abnormal_dopamine_level | 0.89114259 |
| 88 | MP0005167_abnormal_blood-brain_barrier | 0.88907518 |
| 89 | MP0002152_abnormal_brain_morphology | 0.88061737 |
| 90 | MP0002735_abnormal_chemical_nociception | 0.87756799 |
| 91 | MP0005076_abnormal_cell_differentiation | 0.86971798 |
| 92 | MP0005058_abnormal_lysosome_morphology | 0.84284294 |
| 93 | MP0003953_abnormal_hormone_level | 0.83739867 |
| 94 | MP0002752_abnormal_somatic_nervous | 0.82867714 |
| 95 | MP0002896_abnormal_bone_mineralization | 0.82033462 |
| 96 | MP0003075_altered_response_to | 0.81630985 |
| 97 | MP0002229_neurodegeneration | 0.81129741 |
| 98 | MP0003959_abnormal_lean_body | 0.80875993 |
| 99 | MP0005409_darkened_coat_color | 0.80547320 |
| 100 | MP0001986_abnormal_taste_sensitivity | 0.79725569 |
| 101 | MP0003942_abnormal_urinary_system | 0.79008819 |
| 102 | MP0005310_abnormal_salivary_gland | 0.76978146 |
| 103 | MP0002928_abnormal_bile_duct | 0.74900769 |
| 104 | MP0003690_abnormal_glial_cell | 0.74794564 |
| 105 | MP0005448_abnormal_energy_balance | 0.72352411 |
| 106 | MP0003631_nervous_system_phenotype | 0.72068751 |
| 107 | MP0003861_abnormal_nervous_system | 0.71281802 |
| 108 | MP0004145_abnormal_muscle_electrophysio | 0.71200956 |
| 109 | MP0001765_abnormal_ion_homeostasis | 0.70841802 |
| 110 | MP0002163_abnormal_gland_morphology | 0.70233530 |
| 111 | MP0002249_abnormal_larynx_morphology | 0.70119385 |
| 112 | MP0004130_abnormal_muscle_cell | 0.69968149 |
| 113 | MP0002837_dystrophic_cardiac_calcinosis | 0.69295973 |
| 114 | MP0000343_altered_response_to | 0.69099727 |
| 115 | MP0002736_abnormal_nociception_after | 0.68419827 |
| 116 | MP0001485_abnormal_pinna_reflex | 0.68358586 |
| 117 | MP0005499_abnormal_olfactory_system | 0.67892158 |
| 118 | MP0005394_taste/olfaction_phenotype | 0.67892158 |
| 119 | MP0003938_abnormal_ear_development | 0.66969173 |
| 120 | MP0003045_fibrosis | 0.66617748 |
| 121 | MP0001958_emphysema | 0.66172469 |
| 122 | MP0002089_abnormal_postnatal_growth/wei | 0.65796983 |
| 123 | MP0000681_abnormal_thyroid_gland | 0.65282287 |
| 124 | MP0005551_abnormal_eye_electrophysiolog | 0.65259334 |
| 125 | MP0001529_abnormal_vocalization | 0.64809458 |
| 126 | MP0005257_abnormal_intraocular_pressure | 0.63655814 |
| 127 | MP0003279_aneurysm | 0.61420632 |
| 128 | MP0003137_abnormal_impulse_conducting | 0.56063678 |
| 129 | MP0002090_abnormal_vision | 0.55525876 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 5.23625454 |
| 2 | Visual hallucinations (HP:0002367) | 4.24140724 |
| 3 | Papilledema (HP:0001085) | 3.89221997 |
| 4 | Abnormality of binocular vision (HP:0011514) | 3.69570062 |
| 5 | Diplopia (HP:0000651) | 3.69570062 |
| 6 | Supranuclear gaze palsy (HP:0000605) | 3.67720183 |
| 7 | Agitation (HP:0000713) | 3.53165016 |
| 8 | Focal motor seizures (HP:0011153) | 3.37216853 |
| 9 | Myokymia (HP:0002411) | 3.31579182 |
| 10 | Hyperinsulinemic hypoglycemia (HP:0000825) | 3.31277336 |
| 11 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 3.27820975 |
| 12 | Focal seizures (HP:0007359) | 3.27095849 |
| 13 | Hypoglycemic seizures (HP:0002173) | 3.19765145 |
| 14 | Obstructive sleep apnea (HP:0002870) | 3.06362384 |
| 15 | Macroorchidism (HP:0000053) | 3.02055259 |
| 16 | Ankle clonus (HP:0011448) | 2.99561543 |
| 17 | Abnormality of glycolipid metabolism (HP:0010969) | 2.95092227 |
| 18 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.95092227 |
| 19 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.95092227 |
| 20 | Symptomatic seizures (HP:0011145) | 2.90590443 |
| 21 | Hyperacusis (HP:0010780) | 2.90153680 |
| 22 | Failure to thrive in infancy (HP:0001531) | 2.83187328 |
| 23 | Sleep apnea (HP:0010535) | 2.82790057 |
| 24 | Depression (HP:0000716) | 2.75407639 |
| 25 | Insomnia (HP:0100785) | 2.73596412 |
| 26 | Hypercortisolism (HP:0001578) | 2.67191851 |
| 27 | Neoplasm of the heart (HP:0100544) | 2.60965073 |
| 28 | Hypsarrhythmia (HP:0002521) | 2.44434571 |
| 29 | EEG with generalized epileptiform discharges (HP:0011198) | 2.43484963 |
| 30 | Action tremor (HP:0002345) | 2.41031538 |
| 31 | Decreased circulating renin level (HP:0003351) | 2.40406174 |
| 32 | Abnormal eating behavior (HP:0100738) | 2.39142577 |
| 33 | Menstrual irregularities (HP:0000858) | 2.38250310 |
| 34 | Epileptiform EEG discharges (HP:0011182) | 2.34848189 |
| 35 | Nuclear cataract (HP:0100018) | 2.32290263 |
| 36 | Abnormality of endocrine pancreas physiology (HP:0012093) | 2.31140336 |
| 37 | Abnormality of the pancreatic islet cells (HP:0006476) | 2.31140336 |
| 38 | Annular pancreas (HP:0001734) | 2.28615983 |
| 39 | Genetic anticipation (HP:0003743) | 2.28409223 |
| 40 | Elfin facies (HP:0004428) | 2.25687661 |
| 41 | Truncal ataxia (HP:0002078) | 2.25444956 |
| 42 | Anxiety (HP:0000739) | 2.21779112 |
| 43 | Buphthalmos (HP:0000557) | 2.21499292 |
| 44 | Hyperparathyroidism (HP:0000843) | 2.19887483 |
| 45 | Pheochromocytoma (HP:0002666) | 2.19837547 |
| 46 | Disinhibition (HP:0000734) | 2.18808288 |
| 47 | Epileptic encephalopathy (HP:0200134) | 2.16888247 |
| 48 | Abnormality of the corticospinal tract (HP:0002492) | 2.16111058 |
| 49 | Turricephaly (HP:0000262) | 2.14818491 |
| 50 | Postural instability (HP:0002172) | 2.12932374 |
| 51 | Apathy (HP:0000741) | 2.12368081 |
| 52 | Absence seizures (HP:0002121) | 2.10251599 |
| 53 | Dysostosis multiplex (HP:0000943) | 2.08310435 |
| 54 | Progressive cerebellar ataxia (HP:0002073) | 2.07883344 |
| 55 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.07410115 |
| 56 | Mucopolysacchariduria (HP:0008155) | 2.07410115 |
| 57 | Intention tremor (HP:0002080) | 2.06740637 |
| 58 | Abnormality of the lower motor neuron (HP:0002366) | 2.06086821 |
| 59 | Generalized tonic-clonic seizures (HP:0002069) | 2.05933507 |
| 60 | Atonic seizures (HP:0010819) | 2.04177345 |
| 61 | Renal duplication (HP:0000075) | 2.03708914 |
| 62 | Insulin-resistant diabetes mellitus (HP:0000831) | 2.02641678 |
| 63 | Poor eye contact (HP:0000817) | 2.02595929 |
| 64 | Large for gestational age (HP:0001520) | 2.02293860 |
| 65 | Abnormal pancreas size (HP:0012094) | 2.02141615 |
| 66 | Focal dystonia (HP:0004373) | 2.01999408 |
| 67 | Increased circulating renin level (HP:0000848) | 2.01475976 |
| 68 | Hyperglycemia (HP:0003074) | 2.01026028 |
| 69 | Amblyopia (HP:0000646) | 1.98556277 |
| 70 | Hypokalemia (HP:0002900) | 1.98277980 |
| 71 | Shawl scrotum (HP:0000049) | 1.97179602 |
| 72 | Hemiparesis (HP:0001269) | 1.97066866 |
| 73 | Dialeptic seizures (HP:0011146) | 1.97039735 |
| 74 | Abnormality of the aortic arch (HP:0012303) | 1.96836454 |
| 75 | Absent speech (HP:0001344) | 1.96637569 |
| 76 | Abnormality of the diencephalon (HP:0010662) | 1.96030318 |
| 77 | Abnormality of polysaccharide metabolism (HP:0011012) | 1.95904419 |
| 78 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 1.95904419 |
| 79 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 1.95904419 |
| 80 | Lower limb asymmetry (HP:0100559) | 1.95858882 |
| 81 | Megalencephaly (HP:0001355) | 1.95343233 |
| 82 | Hypoplasia of the corpus callosum (HP:0002079) | 1.94577436 |
| 83 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.94198693 |
| 84 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.94191940 |
| 85 | Hyperventilation (HP:0002883) | 1.93968943 |
| 86 | Pointed chin (HP:0000307) | 1.92946779 |
| 87 | Tetraplegia (HP:0002445) | 1.92553841 |
| 88 | Retinal atrophy (HP:0001105) | 1.92215196 |
| 89 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 1.92075354 |
| 90 | Ventricular fibrillation (HP:0001663) | 1.91726755 |
| 91 | Mutism (HP:0002300) | 1.91628700 |
| 92 | Polyphagia (HP:0002591) | 1.91625252 |
| 93 | Neurofibrillary tangles (HP:0002185) | 1.91082139 |
| 94 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.89277526 |
| 95 | Gait imbalance (HP:0002141) | 1.89036495 |
| 96 | Diminished motivation (HP:0000745) | 1.88764260 |
| 97 | Impaired social interactions (HP:0000735) | 1.88476037 |
| 98 | Abnormal social behavior (HP:0012433) | 1.88476037 |
| 99 | Spinal canal stenosis (HP:0003416) | 1.87946353 |
| 100 | Drooling (HP:0002307) | 1.87838985 |
| 101 | Excessive salivation (HP:0003781) | 1.87838985 |
| 102 | Adrenal overactivity (HP:0002717) | 1.87795819 |
| 103 | Torticollis (HP:0000473) | 1.87752140 |
| 104 | Rapidly progressive (HP:0003678) | 1.87158433 |
| 105 | Craniofacial dystonia (HP:0012179) | 1.86806795 |
| 106 | Hypoventilation (HP:0002791) | 1.85838938 |
| 107 | Aplasia of the phalanges of the hand (HP:0009802) | 1.85529969 |
| 108 | Aplasia involving bones of the extremities (HP:0009825) | 1.85529969 |
| 109 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.85529969 |
| 110 | Open mouth (HP:0000194) | 1.84414868 |
| 111 | Lower limb muscle weakness (HP:0007340) | 1.84110829 |
| 112 | Stereotypic behavior (HP:0000733) | 1.83532347 |
| 113 | Impaired smooth pursuit (HP:0007772) | 1.82894177 |
| 114 | Spastic tetraparesis (HP:0001285) | 1.81724410 |
| 115 | Dementia (HP:0000726) | 1.81454614 |
| 116 | Neuronal loss in central nervous system (HP:0002529) | 1.81058739 |
| 117 | Inappropriate behavior (HP:0000719) | 1.80951127 |
| 118 | Cerebral aneurysm (HP:0004944) | 1.80764571 |
| 119 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.80349121 |
| 120 | Hemiplegia (HP:0002301) | 1.80347130 |
| 121 | Increased cerebral lipofuscin (HP:0011813) | 1.80107534 |
| 122 | Papillary thyroid carcinoma (HP:0002895) | 1.79626685 |
| 123 | Cerebral inclusion bodies (HP:0100314) | 1.79567975 |
| 124 | Limb dystonia (HP:0002451) | 1.78939501 |
| 125 | Overriding aorta (HP:0002623) | 1.78243542 |
| 126 | Postural tremor (HP:0002174) | 1.78168834 |
| 127 | Congenital glaucoma (HP:0001087) | 1.77657964 |
| 128 | Febrile seizures (HP:0002373) | 1.77060803 |
| 129 | Loss of speech (HP:0002371) | 1.76669763 |
| 130 | Abnormality of renin-angiotensin system (HP:0000847) | 1.76002997 |
| 131 | Spastic gait (HP:0002064) | 1.75681586 |
| 132 | Amyotrophic lateral sclerosis (HP:0007354) | 1.75053838 |
| 133 | Hyperphosphatemia (HP:0002905) | 1.74131133 |
| 134 | Status epilepticus (HP:0002133) | 1.73963187 |
| 135 | Restlessness (HP:0000711) | 1.71973368 |
| 136 | Neuroendocrine neoplasm (HP:0100634) | 1.71508565 |
| 137 | Dysmetria (HP:0001310) | 1.71387397 |
| 138 | Urinary urgency (HP:0000012) | 1.71063033 |
| 139 | Clonus (HP:0002169) | 1.69880805 |
| 140 | Abnormality of the metopic suture (HP:0005556) | 1.69623218 |
| 141 | Double outlet right ventricle (HP:0001719) | 1.69314715 |
| 142 | Congenital malformation of the right heart (HP:0011723) | 1.69314715 |
| 143 | Vertebral arch anomaly (HP:0008438) | 1.68453428 |
| 144 | Anomalous pulmonary venous return (HP:0010772) | 1.67767345 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 3.84650431 |
| 2 | MARK1 | 3.17076458 |
| 3 | MAP3K9 | 3.08109147 |
| 4 | PRKD3 | 2.86434262 |
| 5 | INSRR | 2.79861122 |
| 6 | PASK | 2.28807239 |
| 7 | CAMKK1 | 2.24899585 |
| 8 | UHMK1 | 2.13612735 |
| 9 | MAP3K4 | 2.10201547 |
| 10 | SIK2 | 2.08019153 |
| 11 | NTRK1 | 2.04741177 |
| 12 | CASK | 2.02914289 |
| 13 | MAP3K2 | 1.84906857 |
| 14 | PAK6 | 1.81278720 |
| 15 | NTRK2 | 1.81246713 |
| 16 | RIPK4 | 1.79081802 |
| 17 | HIPK2 | 1.78680044 |
| 18 | MINK1 | 1.78357290 |
| 19 | TRIB3 | 1.75913682 |
| 20 | SCYL2 | 1.72808432 |
| 21 | EPHA4 | 1.71016834 |
| 22 | KSR2 | 1.53886588 |
| 23 | FGFR2 | 1.53581133 |
| 24 | PRKCH | 1.52149211 |
| 25 | WNK3 | 1.51177786 |
| 26 | PRPF4B | 1.49184951 |
| 27 | DAPK2 | 1.49073218 |
| 28 | TAOK3 | 1.42687374 |
| 29 | LATS2 | 1.41038195 |
| 30 | MAP2K7 | 1.31185577 |
| 31 | CDK5 | 1.30322731 |
| 32 | KSR1 | 1.29720778 |
| 33 | CAMK1G | 1.29548582 |
| 34 | CDC42BPA | 1.29539786 |
| 35 | PDGFRA | 1.29323821 |
| 36 | RET | 1.28759775 |
| 37 | ALK | 1.27992998 |
| 38 | CAMKK2 | 1.27322401 |
| 39 | MAP3K1 | 1.19186451 |
| 40 | FES | 1.15519984 |
| 41 | MAP3K11 | 1.15455372 |
| 42 | PLK2 | 1.12339628 |
| 43 | PAK3 | 1.10246200 |
| 44 | PTK6 | 1.08666592 |
| 45 | MAP3K10 | 1.08645381 |
| 46 | RIPK1 | 1.05012626 |
| 47 | SGK3 | 1.04009656 |
| 48 | PKN2 | 1.01628014 |
| 49 | MOS | 1.01378676 |
| 50 | MAP2K4 | 1.00343558 |
| 51 | MARK2 | 1.00219826 |
| 52 | SGK2 | 0.98644405 |
| 53 | SGK223 | 0.97984676 |
| 54 | SGK494 | 0.97984676 |
| 55 | RPS6KA2 | 0.96742115 |
| 56 | IRAK2 | 0.95241121 |
| 57 | SIK3 | 0.94154314 |
| 58 | ERBB3 | 0.93316309 |
| 59 | TAOK2 | 0.92392854 |
| 60 | PINK1 | 0.92293739 |
| 61 | CDK15 | 0.91440683 |
| 62 | GRK7 | 0.90054147 |
| 63 | DYRK2 | 0.88562469 |
| 64 | TAOK1 | 0.88210612 |
| 65 | MAPK13 | 0.88129223 |
| 66 | MAP3K13 | 0.85856746 |
| 67 | CAMK1D | 0.82974880 |
| 68 | PNCK | 0.82121940 |
| 69 | STK11 | 0.80604968 |
| 70 | CDK11A | 0.80318677 |
| 71 | ERN1 | 0.76483335 |
| 72 | DYRK1B | 0.76431565 |
| 73 | WNK1 | 0.75462797 |
| 74 | TNIK | 0.74473373 |
| 75 | CAMK2B | 0.71758472 |
| 76 | STK38 | 0.71069195 |
| 77 | TYRO3 | 0.69072704 |
| 78 | ROCK2 | 0.67408909 |
| 79 | CAMK2A | 0.67008956 |
| 80 | MAPK15 | 0.65239211 |
| 81 | SGK1 | 0.64965168 |
| 82 | FGFR3 | 0.63481047 |
| 83 | PKN1 | 0.62206079 |
| 84 | CAMK4 | 0.61613768 |
| 85 | JAK2 | 0.60950654 |
| 86 | MAP3K12 | 0.59819988 |
| 87 | PRKCG | 0.58152956 |
| 88 | JAK1 | 0.57950492 |
| 89 | PTK2 | 0.57783908 |
| 90 | PRKD2 | 0.56761726 |
| 91 | ICK | 0.55598321 |
| 92 | EPHB1 | 0.54969449 |
| 93 | ERBB2 | 0.54200405 |
| 94 | WNK4 | 0.54065376 |
| 95 | DMPK | 0.52607920 |
| 96 | SIK1 | 0.52192323 |
| 97 | FYN | 0.51447079 |
| 98 | TNK2 | 0.51290287 |
| 99 | PRKCZ | 0.49944499 |
| 100 | BMX | 0.49524479 |
| 101 | IRAK1 | 0.49275752 |
| 102 | MAPK10 | 0.49167218 |
| 103 | EPHA3 | 0.48935814 |
| 104 | EPHB2 | 0.48863418 |
| 105 | PRKD1 | 0.48744937 |
| 106 | PRKAA1 | 0.48632217 |
| 107 | PHKG1 | 0.48501259 |
| 108 | PHKG2 | 0.48501259 |
| 109 | RPS6KA3 | 0.48293042 |
| 110 | GRK5 | 0.48001940 |
| 111 | PDPK1 | 0.47923632 |
| 112 | CAMK1 | 0.46306084 |
| 113 | CAMK2G | 0.44458369 |
| 114 | DYRK1A | 0.43816380 |
| 115 | DAPK1 | 0.43556598 |
| 116 | BRSK1 | 0.42572036 |
| 117 | CSNK1G2 | 0.42447714 |
| 118 | FRK | 0.42431723 |
| 119 | CDK19 | 0.42420522 |
| 120 | PRKCE | 0.42293890 |
| 121 | DDR2 | 0.42273776 |
| 122 | CDK14 | 0.42130449 |
| 123 | ARAF | 0.42070645 |
| 124 | CDK18 | 0.42059204 |
| 125 | MAPK12 | 0.41343425 |
| 126 | CDK12 | 0.40805644 |
| 127 | FGR | 0.40669692 |
| 128 | MAPK7 | 0.39642367 |
| 129 | ROCK1 | 0.37904168 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.94258452 |
| 2 | Insulin secretion_Homo sapiens_hsa04911 | 2.51346743 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.33803754 |
| 4 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 2.31610585 |
| 5 | GABAergic synapse_Homo sapiens_hsa04727 | 2.17546547 |
| 6 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.04870662 |
| 7 | Circadian entrainment_Homo sapiens_hsa04713 | 2.04811721 |
| 8 | Olfactory transduction_Homo sapiens_hsa04740 | 1.95983211 |
| 9 | Cocaine addiction_Homo sapiens_hsa05030 | 1.93096586 |
| 10 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.91048940 |
| 11 | Morphine addiction_Homo sapiens_hsa05032 | 1.89613500 |
| 12 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.82195077 |
| 13 | Long-term potentiation_Homo sapiens_hsa04720 | 1.76383263 |
| 14 | Nicotine addiction_Homo sapiens_hsa05033 | 1.75215747 |
| 15 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.73438453 |
| 16 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.71421470 |
| 17 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.66110917 |
| 18 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.65217415 |
| 19 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.65044416 |
| 20 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.60063762 |
| 21 | Taste transduction_Homo sapiens_hsa04742 | 1.41863172 |
| 22 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.40039201 |
| 23 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.38126661 |
| 24 | Renin secretion_Homo sapiens_hsa04924 | 1.30893491 |
| 25 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.28672686 |
| 26 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.28588301 |
| 27 | Salivary secretion_Homo sapiens_hsa04970 | 1.25611484 |
| 28 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.17547203 |
| 29 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.16421144 |
| 30 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.14494277 |
| 31 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.14387592 |
| 32 | Gap junction_Homo sapiens_hsa04540 | 1.13580069 |
| 33 | Glioma_Homo sapiens_hsa05214 | 1.11417605 |
| 34 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.08296939 |
| 35 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.08089423 |
| 36 | Other glycan degradation_Homo sapiens_hsa00511 | 1.07866564 |
| 37 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.07459194 |
| 38 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.07195180 |
| 39 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.06747933 |
| 40 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.05480266 |
| 41 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.04861871 |
| 42 | Long-term depression_Homo sapiens_hsa04730 | 0.99627903 |
| 43 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.98339452 |
| 44 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.97929855 |
| 45 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.97355604 |
| 46 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.94092584 |
| 47 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.92796450 |
| 48 | Endometrial cancer_Homo sapiens_hsa05213 | 0.91777058 |
| 49 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.89959226 |
| 50 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.89412573 |
| 51 | Melanogenesis_Homo sapiens_hsa04916 | 0.88424235 |
| 52 | Axon guidance_Homo sapiens_hsa04360 | 0.88339029 |
| 53 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.87917633 |
| 54 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.86220377 |
| 55 | Lysosome_Homo sapiens_hsa04142 | 0.83962058 |
| 56 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.83757074 |
| 57 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.82879401 |
| 58 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.81991751 |
| 59 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.81294223 |
| 60 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.80002601 |
| 61 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.79776954 |
| 62 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.78657474 |
| 63 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.77148404 |
| 64 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.77020117 |
| 65 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.77007768 |
| 66 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.75509132 |
| 67 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.74565254 |
| 68 | Insulin resistance_Homo sapiens_hsa04931 | 0.73199992 |
| 69 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.73003797 |
| 70 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.72949241 |
| 71 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.72567090 |
| 72 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.72285527 |
| 73 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.71631323 |
| 74 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.71451549 |
| 75 | Bile secretion_Homo sapiens_hsa04976 | 0.71131289 |
| 76 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.69314141 |
| 77 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.69141560 |
| 78 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.68187360 |
| 79 | Endocytosis_Homo sapiens_hsa04144 | 0.66632378 |
| 80 | Circadian rhythm_Homo sapiens_hsa04710 | 0.65992990 |
| 81 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.64157486 |
| 82 | Prion diseases_Homo sapiens_hsa05020 | 0.63975171 |
| 83 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.62820075 |
| 84 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.61925175 |
| 85 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.61867990 |
| 86 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.61176240 |
| 87 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.60025077 |
| 88 | Phagosome_Homo sapiens_hsa04145 | 0.59976071 |
| 89 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.59608995 |
| 90 | Alcoholism_Homo sapiens_hsa05034 | 0.59325397 |
| 91 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.58652989 |
| 92 | Amoebiasis_Homo sapiens_hsa05146 | 0.56477683 |
| 93 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.55932910 |
| 94 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.55240757 |
| 95 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.54733622 |
| 96 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.54572835 |
| 97 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.54097031 |
| 98 | Colorectal cancer_Homo sapiens_hsa05210 | 0.54026617 |
| 99 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.53618597 |
| 100 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.53531896 |
| 101 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.53441945 |
| 102 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.52707636 |
| 103 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.52516839 |
| 104 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.51803997 |
| 105 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.51668313 |
| 106 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.50831020 |
| 107 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.49827287 |
| 108 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.48843754 |
| 109 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.48210644 |
| 110 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.47259686 |
| 111 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.47161791 |
| 112 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.46857846 |
| 113 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.46713145 |
| 114 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.46562733 |
| 115 | Tuberculosis_Homo sapiens_hsa05152 | 0.46027987 |
| 116 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.45619233 |
| 117 | Platelet activation_Homo sapiens_hsa04611 | 0.45561146 |
| 118 | Phototransduction_Homo sapiens_hsa04744 | 0.45030998 |
| 119 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.44263220 |
| 120 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.44158864 |
| 121 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.44034531 |
| 122 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.43244927 |

