RGCC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)4.79681980
2brown fat cell differentiation (GO:0050873)4.54079515
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.48878528
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.48878528
5negative regulation of phagocytosis (GO:0050765)4.40036241
6regulation of sequestering of triglyceride (GO:0010889)4.12585058
7white fat cell differentiation (GO:0050872)4.11414081
8low-density lipoprotein particle clearance (GO:0034383)3.88851653
9modulation of growth of symbiont involved in interaction with host (GO:0044144)3.87770774
10regulation of growth of symbiont in host (GO:0044126)3.87770774
11negative regulation of growth of symbiont in host (GO:0044130)3.87770774
12negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.87770774
13cellular response to thyroid hormone stimulus (GO:0097067)3.82991596
14negative regulation of interleukin-12 production (GO:0032695)3.82341425
15ribosomal small subunit assembly (GO:0000028)3.75223778
16response to peptidoglycan (GO:0032494)3.73237103
17antigen processing and presentation of endogenous antigen (GO:0019883)3.67676255
18cellular response to zinc ion (GO:0071294)3.64623386
19tolerance induction (GO:0002507)3.62895567
20vascular endothelial growth factor signaling pathway (GO:0038084)3.54329999
21phagocytosis, recognition (GO:0006910)3.50436944
22negative regulation of erythrocyte differentiation (GO:0045647)3.50196866
23positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.48509878
24lipid storage (GO:0019915)3.48049169
25negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.37898665
26chemical homeostasis within a tissue (GO:0048875)3.33032988
27response to muramyl dipeptide (GO:0032495)3.31047769
28negative regulation of lipid storage (GO:0010888)3.29730622
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.26889939
30cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.26714227
31negative regulation of nitric oxide biosynthetic process (GO:0045019)3.25224358
32negative regulation of cell killing (GO:0031342)3.25171210
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.25171210
34neutrophil mediated immunity (GO:0002446)3.24928536
35myeloid dendritic cell differentiation (GO:0043011)3.24550834
36glycosphingolipid catabolic process (GO:0046479)3.23123565
37regulation of cholesterol storage (GO:0010885)3.20471535
38oligosaccharide catabolic process (GO:0009313)3.20060652
39granulocyte activation (GO:0036230)3.14716712
40positive regulation of chemokine biosynthetic process (GO:0045080)3.14379617
41negative regulation of stress fiber assembly (GO:0051497)3.11527812
42regulation of chemokine biosynthetic process (GO:0045073)3.10490156
43negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.10101230
44lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08604146
45lymph vessel development (GO:0001945)3.08071370
46blood vessel maturation (GO:0001955)3.06608320
47regulation of mononuclear cell migration (GO:0071675)3.04567846
48disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.03916015
49killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.03916015
50viral transcription (GO:0019083)3.03114038
51regulation of B cell receptor signaling pathway (GO:0050855)3.02186157
52myeloid dendritic cell activation (GO:0001773)2.98559278
53positive thymic T cell selection (GO:0045059)2.96925279
54regulation of vitamin D biosynthetic process (GO:0060556)2.96133169
55valine metabolic process (GO:0006573)2.95457458
56angiogenesis involved in wound healing (GO:0060055)2.95411226
57regulation of T cell tolerance induction (GO:0002664)2.94663482
58endothelium development (GO:0003158)2.93828749
59positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92997859
60regulation of interleukin-2 biosynthetic process (GO:0045076)2.88493016
61positive regulation of mast cell activation (GO:0033005)2.86808434
62glycolipid catabolic process (GO:0019377)2.86757956
63SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.86298374
64negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.85329175
65regulation of vasculogenesis (GO:2001212)2.84837203
66heme biosynthetic process (GO:0006783)2.84218803
67regulation of mast cell degranulation (GO:0043304)2.83564980
68regulation of tolerance induction (GO:0002643)2.83392691
69translational termination (GO:0006415)2.82483451
70germinal center formation (GO:0002467)2.81956032
71immunoglobulin mediated immune response (GO:0016064)2.80389181
72regulation of monocyte differentiation (GO:0045655)2.79682045
73macrophage activation (GO:0042116)2.78571800
74cotranslational protein targeting to membrane (GO:0006613)2.78188063
75protein targeting to ER (GO:0045047)2.77645701
76signal peptide processing (GO:0006465)2.76796554
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.76523853
78regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.76235411
79myeloid leukocyte mediated immunity (GO:0002444)2.75817608
80endothelial cell morphogenesis (GO:0001886)2.75721314
81neutrophil activation (GO:0042119)2.74379345
82regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73962543
83response to thyroid hormone (GO:0097066)2.72859200
84T cell migration (GO:0072678)2.72147798
85protoporphyrinogen IX biosynthetic process (GO:0006782)2.71830136
86regulation of endothelial cell differentiation (GO:0045601)2.71102459
87macrophage activation involved in immune response (GO:0002281)2.70854348
88amino sugar catabolic process (GO:0046348)2.70852593
89morphogenesis of an endothelium (GO:0003159)2.70413429
90endothelial tube morphogenesis (GO:0061154)2.70413429
91hydrogen peroxide catabolic process (GO:0042744)2.69897841
92regulation of leukocyte degranulation (GO:0043300)2.69337801
93macrophage chemotaxis (GO:0048246)2.68059748
94transcytosis (GO:0045056)2.65292668
95regulation of chronic inflammatory response (GO:0002676)2.64888981
96myeloid cell activation involved in immune response (GO:0002275)2.63710517
97regulation of macrophage chemotaxis (GO:0010758)2.63581856
98positive regulation of mast cell degranulation (GO:0043306)2.61948627
99positive regulation of mast cell activation involved in immune response (GO:0033008)2.61948627
100chondroitin sulfate biosynthetic process (GO:0030206)2.61865733
101positive regulation of B cell differentiation (GO:0045579)2.61736751
102establishment of protein localization to endoplasmic reticulum (GO:0072599)2.59645122
103protein localization to endoplasmic reticulum (GO:0070972)2.59540618
104regulation of integrin-mediated signaling pathway (GO:2001044)2.58940666
105ovulation from ovarian follicle (GO:0001542)2.58652767
106regulation of T-helper 2 cell differentiation (GO:0045628)2.58595152
107regulation of lymphocyte chemotaxis (GO:1901623)2.58127762
108microglial cell activation (GO:0001774)2.58037848
109regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.57887337
110myeloid leukocyte activation (GO:0002274)2.57799391
111positive regulation of gamma-delta T cell activation (GO:0046645)2.57695314
112monocyte chemotaxis (GO:0002548)2.57554481
113definitive hemopoiesis (GO:0060216)2.57028890
114ribosomal small subunit biogenesis (GO:0042274)2.56376796
115protoporphyrinogen IX metabolic process (GO:0046501)2.56317787
116regulation of mast cell activation involved in immune response (GO:0033006)2.55961919
117positive regulation of tolerance induction (GO:0002645)2.55742462
118NIK/NF-kappaB signaling (GO:0038061)2.55372055
119response to fungus (GO:0009620)2.55306426
120interferon-gamma-mediated signaling pathway (GO:0060333)2.54953769
121defense response to fungus (GO:0050832)2.54536190
122cellular response to interferon-beta (GO:0035458)2.54474068
123pentose-phosphate shunt (GO:0006098)2.54230040
124regulation of gamma-delta T cell differentiation (GO:0045586)2.54178741
125cellular extravasation (GO:0045123)2.54102039
126regulation of mast cell activation (GO:0033003)2.53913746
127peptide catabolic process (GO:0043171)2.53829742
128positive T cell selection (GO:0043368)2.53429428
129negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.53175051
130positive regulation of p38MAPK cascade (GO:1900745)2.53146329
131regulation of myeloid leukocyte mediated immunity (GO:0002886)2.51841600
132positive regulation of Rap GTPase activity (GO:0032854)2.51835324
133ceramide catabolic process (GO:0046514)2.50852125
134negative regulation of cytokine production involved in immune response (GO:0002719)2.50110021
135dendritic cell differentiation (GO:0097028)2.49922721
136negative regulation of interleukin-6 production (GO:0032715)2.49199977
137NADPH regeneration (GO:0006740)2.45338596
138endothelial cell differentiation (GO:0045446)2.44455570
139response to laminar fluid shear stress (GO:0034616)2.44352876
140negative regulation of granulocyte differentiation (GO:0030853)2.43998115
141leukocyte mediated cytotoxicity (GO:0001909)2.43638521
142lymphocyte chemotaxis (GO:0048247)2.43141669
143positive regulation of glomerulus development (GO:0090193)2.42965374
144secretory granule organization (GO:0033363)2.42937504
145cGMP-mediated signaling (GO:0019934)2.42852504
146response to protozoan (GO:0001562)2.42182830
147positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.40693075
148positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.40638266
149defense response to protozoan (GO:0042832)2.40174487
150regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.40063410
151regulation of response to interferon-gamma (GO:0060330)2.39938455
152neutrophil activation involved in immune response (GO:0002283)2.39526966
153positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.38974977
154dermatan sulfate metabolic process (GO:0030205)2.37892492
155mannose metabolic process (GO:0006013)2.37872593
156regulation of gamma-delta T cell activation (GO:0046643)2.37811747
157cellular response to arsenic-containing substance (GO:0071243)2.37465527
158negative thymic T cell selection (GO:0045060)2.37198086
159positive regulation of leukocyte degranulation (GO:0043302)2.37111677
160positive regulation of macrophage differentiation (GO:0045651)2.36905939
161T cell selection (GO:0045058)2.36630305
162positive regulation of smooth muscle cell proliferation (GO:0048661)2.36506724
163leukocyte aggregation (GO:0070486)2.36315143
164positive regulation of astrocyte differentiation (GO:0048711)2.35778251
165regulation of lymphocyte migration (GO:2000401)2.35683756
166neutrophil chemotaxis (GO:0030593)2.35644152
167positive regulation of monocyte chemotaxis (GO:0090026)2.35352631
168positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.35246625
169negative regulation of interleukin-8 production (GO:0032717)2.35193101
170endothelial cell chemotaxis (GO:0035767)2.34567117
171translational elongation (GO:0006414)2.33206693
172negative regulation of protein autophosphorylation (GO:0031953)2.33158982
173positive regulation of lipid storage (GO:0010884)2.33124738
174keratan sulfate catabolic process (GO:0042340)2.32321796
175gas transport (GO:0015669)2.32269397
176lipid particle organization (GO:0034389)2.32101825
177establishment of endothelial barrier (GO:0061028)2.31376098
178trabecula morphogenesis (GO:0061383)2.30129162
179regulation of lipid storage (GO:0010883)2.29265072
180serine transport (GO:0032329)2.29238081
181mast cell activation (GO:0045576)2.29217413
182positive regulation of cholesterol efflux (GO:0010875)2.28875981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.43788801
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.50951863
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.90201641
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.79950482
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.63961810
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.59654424
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.43422318
8GATA1_22025678_ChIP-Seq_K562_Human3.28822134
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.90023924
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.88891023
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.84271192
12E2F7_22180533_ChIP-Seq_HELA_Human2.77730707
13SCL_19346495_ChIP-Seq_HPC-7_Human2.61507391
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.60647306
15CLOCK_20551151_ChIP-Seq_293T_Human2.57663443
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.55818463
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.37973969
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.37375882
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16699950
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13996768
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11129572
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08820476
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02917612
24RUNX_20019798_ChIP-Seq_JUKART_Human2.01838729
25VDR_24763502_ChIP-Seq_THP-1_Human1.92893133
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.90486081
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88061691
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86286873
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.85542036
30MAF_26560356_Chip-Seq_TH1_Human1.82340675
31VDR_21846776_ChIP-Seq_THP-1_Human1.82290895
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.80831190
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74393071
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73868385
35MYB_26560356_Chip-Seq_TH2_Human1.71573689
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70287166
37TCF7_22412390_ChIP-Seq_EML_Mouse1.70215258
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69430144
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69264995
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.67992495
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67930777
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67136536
43KDM2B_26808549_Chip-Seq_DND41_Human1.64404950
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.63234518
45GATA1_19941826_ChIP-Seq_K562_Human1.62211920
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60864780
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59331338
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56702371
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.54324631
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54134867
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.52200905
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52178057
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51361204
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47726902
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.47664869
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42831804
57AR_21572438_ChIP-Seq_LNCaP_Human1.42813032
58ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.41602765
59LXR_22292898_ChIP-Seq_THP-1_Human1.39556677
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39456468
61IRF8_27001747_Chip-Seq_BMDM_Mouse1.38696937
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38489859
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37750309
64VDR_24787735_ChIP-Seq_THP-1_Human1.36742595
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35123409
66MYB_26560356_Chip-Seq_TH1_Human1.34315345
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34053407
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29829119
69PU_27001747_Chip-Seq_BMDM_Mouse1.28643952
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23235021
71GATA3_27048872_Chip-Seq_THYMUS_Human1.21899345
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21276050
73GATA2_19941826_ChIP-Seq_K562_Human1.21198398
74SPI1_23547873_ChIP-Seq_NB4_Human1.21063749
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21022618
76UTX_26944678_Chip-Seq_JUKART_Human1.18181370
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17971712
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17960575
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.17844946
80P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17658362
81CJUN_26792858_Chip-Seq_BT549_Human1.17000668
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.16264368
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16124213
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15789492
85PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15658807
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15626532
87KDM2B_26808549_Chip-Seq_K562_Human1.14097986
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14095320
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13709771
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13032658
91MAF_26560356_Chip-Seq_TH2_Human1.12974422
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10120861
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.09904465
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08566734
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08566734
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07844626
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07550851
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07326720
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06257536
100MYC_22102868_ChIP-Seq_BL_Human1.05812995
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05183223
102SPI1_23127762_ChIP-Seq_K562_Human1.03359765
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02050049
104SOX2_20726797_ChIP-Seq_SW620_Human0.98289117
105TBX20_22080862_ChIP-Seq_HEART_Mouse0.98257389
106TBX20_22328084_ChIP-Seq_HEART_Mouse0.98257389
107PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97119174
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97061565
109JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95977061
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95423995
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92739118
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92657632
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.91948107
114CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91091495
115ZNF263_19887448_ChIP-Seq_K562_Human0.91079989
116GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90810323
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90318054
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90072147
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89995086
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89167767
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88902437
122GATA3_26560356_Chip-Seq_TH2_Human0.86718745
123CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83423092
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82811792
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81493281
126IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80832069
127PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80454899
128GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77644326
129NCOR1_26117541_ChIP-Seq_K562_Human0.76417467
130KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.75630728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.83709937
2MP0005670_abnormal_white_adipose3.55511227
3MP0005058_abnormal_lysosome_morphology3.11913468
4MP0001853_heart_inflammation3.02337922
5MP0009840_abnormal_foam_cell2.86467392
6MP0001879_abnormal_lymphatic_vessel2.76328998
7MP0006082_CNS_inflammation2.73386618
8MP0003172_abnormal_lysosome_physiology2.69502072
9MP0000604_amyloidosis2.48062530
10MP0004147_increased_porphyrin_level2.36315063
11MP0000343_altered_response_to2.18443424
12MP0004782_abnormal_surfactant_physiolog2.12702943
13MP0003436_decreased_susceptibility_to2.12402593
14MP0003828_pulmonary_edema2.11965249
15MP0005666_abnormal_adipose_tissue2.08606213
16MP0004185_abnormal_adipocyte_glucose2.01841267
17MP0001958_emphysema1.97347062
18MP0000685_abnormal_immune_system1.96384416
19MP0002166_altered_tumor_susceptibility1.94230372
20MP0009785_altered_susceptibility_to1.93648146
21MP0001533_abnormal_skeleton_physiology1.92606389
22MP0003303_peritoneal_inflammation1.92168367
23MP0005164_abnormal_response_to1.85680939
24MP0004510_myositis1.84749099
25MP0004130_abnormal_muscle_cell1.84215182
26MP0009333_abnormal_splenocyte_physiolog1.83076918
27MP0004947_skin_inflammation1.82729191
28MP0001835_abnormal_antigen_presentation1.77099589
29MP0006054_spinal_hemorrhage1.74788499
30MP0003329_amyloid_beta_deposits1.71321305
31MP0001545_abnormal_hematopoietic_system1.67427344
32MP0005397_hematopoietic_system_phenotyp1.67427344
33MP0002419_abnormal_innate_immunity1.67285574
34MP0002933_joint_inflammation1.65957108
35MP0003763_abnormal_thymus_physiology1.63070385
36MP0003191_abnormal_cellular_cholesterol1.62849953
37MP0003186_abnormal_redox_activity1.60916265
38MP0002148_abnormal_hypersensitivity_rea1.60524488
39MP0002405_respiratory_system_inflammati1.59352193
40MP0000920_abnormal_myelination1.55091365
41MP0005167_abnormal_blood-brain_barrier1.52660383
42MP0005000_abnormal_immune_tolerance1.52081386
43MP0004272_abnormal_basement_membrane1.50768939
44MP0002006_tumorigenesis1.49258535
45MP0005025_abnormal_response_to1.45773969
46MP0003646_muscle_fatigue1.43943899
47MP0003656_abnormal_erythrocyte_physiolo1.43725410
48MP0001790_abnormal_immune_system1.38661457
49MP0005387_immune_system_phenotype1.38661457
50MP0005451_abnormal_body_composition1.38300941
51MP0005671_abnormal_response_to1.36855446
52MP0005375_adipose_tissue_phenotype1.36251033
53MP0003279_aneurysm1.34909591
54MP0005166_decreased_susceptibility_to1.32517557
55MP0000465_gastrointestinal_hemorrhage1.31998668
56MP0010368_abnormal_lymphatic_system1.31933913
57MP0005310_abnormal_salivary_gland1.31391398
58MP0005165_increased_susceptibility_to1.29910878
59MP0002420_abnormal_adaptive_immunity1.29802566
60MP0009384_cardiac_valve_regurgitation1.28999796
61MP0001819_abnormal_immune_cell1.28539186
62MP0008438_abnormal_cutaneous_collagen1.27636159
63MP0002254_reproductive_system_inflammat1.26745172
64MP0009379_abnormal_foot_pigmentation1.26346266
65MP0004883_abnormal_blood_vessel1.26287625
66MP0003448_altered_tumor_morphology1.25764081
67MP0000858_altered_metastatic_potential1.25588361
68MP0002139_abnormal_hepatobiliary_system1.24939880
69MP0009278_abnormal_bone_marrow1.24752180
70MP0002452_abnormal_antigen_presenting1.24431380
71MP0002971_abnormal_brown_adipose1.23524549
72MP0009115_abnormal_fat_cell1.22121706
73MP0002723_abnormal_immune_serum1.19706908
74MP0000383_abnormal_hair_follicle1.19645265
75MP0008469_abnormal_protein_level1.19387270
76MP0001851_eye_inflammation1.18740286
77MP0000249_abnormal_blood_vessel1.17820666
78MP0000013_abnormal_adipose_tissue1.16780900
79MP0008004_abnormal_stomach_pH1.15362953
80MP0005390_skeleton_phenotype1.13847943
81MP0006138_congestive_heart_failure1.13265183
82MP0010155_abnormal_intestine_physiology1.10271958
83MP0002998_abnormal_bone_remodeling1.10218530
84MP0001800_abnormal_humoral_immune1.10159899
85MP0003453_abnormal_keratinocyte_physiol1.09585825
86MP0001881_abnormal_mammary_gland1.08843574
87MP0002396_abnormal_hematopoietic_system1.07250837
88MP0003950_abnormal_plasma_membrane1.06948888
89MP0001542_abnormal_bone_strength1.06557376
90MP0001501_abnormal_sleep_pattern1.04798262
91MP0003075_altered_response_to1.04453320
92MP0009764_decreased_sensitivity_to1.01823424
93MP0008995_early_reproductive_senescence0.99525005
94MP0005595_abnormal_vascular_smooth0.99403282
95MP0001845_abnormal_inflammatory_respons0.98998121
96MP0002398_abnormal_bone_marrow0.98187468
97MP0003091_abnormal_cell_migration0.97495953
98MP0003011_delayed_dark_adaptation0.97318627
99MP0002132_abnormal_respiratory_system0.94378471
100MP0000716_abnormal_immune_system0.91980214
101MP0002133_abnormal_respiratory_system0.90948080
102MP0005388_respiratory_system_phenotype0.90948080
103MP0002722_abnormal_immune_system0.90254735
104MP0005464_abnormal_platelet_physiology0.90052570
105MP0005385_cardiovascular_system_phenoty0.89564465
106MP0001544_abnormal_cardiovascular_syste0.89564465
107MP0001663_abnormal_digestive_system0.88033441
108MP0003566_abnormal_cell_adhesion0.87310923
109MP0004484_altered_response_of0.87141318
110MP0008260_abnormal_autophagy0.87011526
111MP0000767_abnormal_smooth_muscle0.86596367
112MP0002009_preneoplasia0.86492588
113MP0008874_decreased_physiological_sensi0.86320089
114MP0003941_abnormal_skin_development0.86115621
115MP0000750_abnormal_muscle_regeneration0.85876299
116MP0002877_abnormal_melanocyte_morpholog0.85750637
117MP0001873_stomach_inflammation0.83494125
118MP0002429_abnormal_blood_cell0.83110900
119MP0003866_abnormal_defecation0.82341605
120MP0002796_impaired_skin_barrier0.81566302
121MP0003300_gastrointestinal_ulcer0.81427190
122MP0002138_abnormal_hepatobiliary_system0.81039108
123MP0009763_increased_sensitivity_to0.80689823
124MP0003690_abnormal_glial_cell0.80561741
125MP0003795_abnormal_bone_structure0.80360165
126MP0000689_abnormal_spleen_morphology0.80206077
127MP0000703_abnormal_thymus_morphology0.75428657
128MP0003633_abnormal_nervous_system0.75297529
129MP0005647_abnormal_sex_gland0.75267217
130MP0004808_abnormal_hematopoietic_stem0.72902448
131MP0002332_abnormal_exercise_endurance0.71432333
132MP0005535_abnormal_body_temperature0.70071502
133MP0003634_abnormal_glial_cell0.66883400
134MP0005076_abnormal_cell_differentiation0.62192444
135MP0003045_fibrosis0.61999754

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.16813183
2Abnormality of liposaccharide metabolism (HP:0010968)6.16813183
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.16813183
4Epiphyseal dysplasia (HP:0002656)4.89633897
5Increased cerebral lipofuscin (HP:0011813)4.61464433
6Abnormality of macrophages (HP:0004311)4.36215245
7Irregular epiphyses (HP:0010582)4.22222291
8Dysostosis multiplex (HP:0000943)3.98793984
9Vacuolated lymphocytes (HP:0001922)3.95726607
10Increased neuronal autofluorescent lipopigment (HP:0002074)3.93944243
11Neurofibrillary tangles (HP:0002185)3.65237041
12Cupped ribs (HP:0000887)3.56700518
13Systemic lupus erythematosus (HP:0002725)3.51861638
14Elevated erythrocyte sedimentation rate (HP:0003565)3.49999307
15Loss of speech (HP:0002371)3.49639671
16Reduced subcutaneous adipose tissue (HP:0003758)3.39419313
17Autoimmune thrombocytopenia (HP:0001973)3.31005176
18Mutism (HP:0002300)3.23185169
19Disinhibition (HP:0000734)3.08859129
20Interstitial pulmonary disease (HP:0006530)3.08650530
21Onycholysis (HP:0001806)3.03853818
22Acanthosis nigricans (HP:0000956)3.02651188
23Eczematoid dermatitis (HP:0000976)3.02544195
24Abnormality of glycosaminoglycan metabolism (HP:0004371)2.99605278
25Abnormality of mucopolysaccharide metabolism (HP:0011020)2.99605278
26Abnormality of polysaccharide metabolism (HP:0011012)2.99605278
27Thrombocytosis (HP:0001894)2.97643771
28Recurrent gram-negative bacterial infections (HP:0005420)2.93317369
29Myocardial infarction (HP:0001658)2.93160455
30Abnormality of binocular vision (HP:0011514)2.91454825
31Diplopia (HP:0000651)2.91454825
32Eosinophilia (HP:0001880)2.89695357
33Hypertriglyceridemia (HP:0002155)2.85863707
34Mucopolysacchariduria (HP:0008155)2.81887879
35Urinary glycosaminoglycan excretion (HP:0003541)2.81887879
36Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.74674141
37Abnormal number of erythroid precursors (HP:0012131)2.67721495
38Small epiphyses (HP:0010585)2.66507633
39Myositis (HP:0100614)2.66256653
40Abnormality of cells of the erythroid lineage (HP:0012130)2.65355154
41Cerebral inclusion bodies (HP:0100314)2.65324264
42Abnormal tarsal ossification (HP:0008369)2.65117437
43Flat capital femoral epiphysis (HP:0003370)2.62475893
44Abnormality of the nasal mucosa (HP:0000433)2.58635230
45Amyloidosis (HP:0011034)2.56369431
46Axonal loss (HP:0003447)2.55645096
47Apathy (HP:0000741)2.54690826
48Abnormality of the axillary hair (HP:0100134)2.54232668
49Abnormality of secondary sexual hair (HP:0009888)2.54232668
50Diminished motivation (HP:0000745)2.54028898
51Vitreoretinal degeneration (HP:0000655)2.53427426
52Neuronal loss in central nervous system (HP:0002529)2.50112902
53Supranuclear gaze palsy (HP:0000605)2.46303383
54Recurrent abscess formation (HP:0002722)2.46225601
55Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.45239929
56Granulocytopenia (HP:0001913)2.44716653
57Absent epiphyses (HP:0010577)2.41420982
58Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.41420982
59Polycythemia (HP:0001901)2.40991291
60Vasculitis (HP:0002633)2.40967617
61Mesangial abnormality (HP:0001966)2.40933867
62Abnormality of the vasculature of the conjunctiva (HP:0008054)2.40539918
63Stomatitis (HP:0010280)2.40437922
64Abnormality of eosinophils (HP:0001879)2.38641582
65Increased CSF protein (HP:0002922)2.37605924
66Meningitis (HP:0001287)2.36075464
67Retrobulbar optic neuritis (HP:0100654)2.36051843
68Optic neuritis (HP:0100653)2.36051843
69Restrictive lung disease (HP:0002091)2.35212412
70Abnormality of the periventricular white matter (HP:0002518)2.33801584
71Oligomenorrhea (HP:0000876)2.31919231
72Cervical subluxation (HP:0003308)2.28276110
73Recurrent viral infections (HP:0004429)2.28065735
74B lymphocytopenia (HP:0010976)2.26141824
75Abnormality of B cell number (HP:0010975)2.26141824
76Chronic otitis media (HP:0000389)2.25866505
77Metaphyseal dysplasia (HP:0100255)2.25708296
78Abnormality of the prostate (HP:0008775)2.25179804
79T lymphocytopenia (HP:0005403)2.24101886
80Abnormality of T cell number (HP:0011839)2.23671356
81Cellulitis (HP:0100658)2.23638289
82Recurrent skin infections (HP:0001581)2.23039842
83Abnormality of the vertebral endplates (HP:0005106)2.22742676
84Reticulocytopenia (HP:0001896)2.22251117
85Multiple enchondromatosis (HP:0005701)2.21729142
86Nuclear cataract (HP:0100018)2.20082181
87Increased serum ferritin (HP:0003281)2.19959722
88Autoimmune hemolytic anemia (HP:0001890)2.19543627
89Nausea (HP:0002018)2.19392156
90Segmental peripheral demyelination/remyelination (HP:0003481)2.18702362
91Irregular vertebral endplates (HP:0003301)2.18650983
92Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.18521537
93Abnormality of femoral epiphyses (HP:0006499)2.18521537
94Peripheral hypomyelination (HP:0007182)2.17403520
95Global brain atrophy (HP:0002283)2.17319001
96Asymmetric septal hypertrophy (HP:0001670)2.16867751
97Thyroid-stimulating hormone excess (HP:0002925)2.15461433
98Flat acetabular roof (HP:0003180)2.13786853
99Slow saccadic eye movements (HP:0000514)2.13779836
100Combined immunodeficiency (HP:0005387)2.13730910
101Gingivitis (HP:0000230)2.13591547
102Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.13403044
103Increased muscle lipid content (HP:0009058)2.12302177
104Prolonged bleeding time (HP:0003010)2.11042981
105Epistaxis (HP:0000421)2.10842483
106Adactyly (HP:0009776)2.09569431
107Metaphyseal cupping (HP:0003021)2.09550199
108Pulmonary infiltrates (HP:0002113)2.07809027
109Esophageal neoplasm (HP:0100751)2.07251654
110Neoplasm of head and neck (HP:0012288)2.07251654
111Ovoid vertebral bodies (HP:0003300)2.05625449
112Glossoptosis (HP:0000162)2.04889515
113Abnormal foot bone ossification (HP:0010675)2.04060229
114Abnormality of the femoral head (HP:0003368)2.02652415
115Polyneuropathy (HP:0001271)2.02440278
116Hypoplastic ischia (HP:0003175)2.01884105
117Recurrent bronchitis (HP:0002837)2.00026597
118Bone cyst (HP:0012062)1.99348954
119Pulmonary embolism (HP:0002204)1.96871249
120Tetraparesis (HP:0002273)1.95975610
121Respiratory distress (HP:0002098)1.94677447
122Genu varum (HP:0002970)1.94458122
123Abnormality of the epiphysis of the femoral head (HP:0010574)1.93981270
124Petechiae (HP:0000967)1.93773741
125Abnormality of the lumbar spine (HP:0100712)1.91979162
126Leukocytosis (HP:0001974)1.91832587
127Basal ganglia calcification (HP:0002135)1.91250987
128Obstructive lung disease (HP:0006536)1.91037171
129Chronic obstructive pulmonary disease (HP:0006510)1.91037171
130Recurrent bacterial skin infections (HP:0005406)1.90947494
131Progressive neurologic deterioration (HP:0002344)1.90610788
132Congenital, generalized hypertrichosis (HP:0004540)1.89132816
133Nasal polyposis (HP:0100582)1.89035930
134Recurrent fungal infections (HP:0002841)1.88869628
135Hematochezia (HP:0002573)1.88514649
136Chest pain (HP:0100749)1.88174267
137Pulmonary fibrosis (HP:0002206)1.88118202
138Abnormality of iron homeostasis (HP:0011031)1.87072579
139Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.86708479
140Paralysis (HP:0003470)1.86547692
141Increased IgE level (HP:0003212)1.86479707
142Pustule (HP:0200039)1.86423974
143Keratoconjunctivitis sicca (HP:0001097)1.86318682
144Spontaneous hematomas (HP:0007420)1.85509706
145Orchitis (HP:0100796)1.85425197
146Severe combined immunodeficiency (HP:0004430)1.83893155
147Dementia (HP:0000726)1.83870906
148Acrocyanosis (HP:0001063)1.83649336
149Metaphyseal irregularity (HP:0003025)1.82875144
150Urticaria (HP:0001025)1.80991666
151Conjunctival telangiectasia (HP:0000524)1.80969316
152Skin ulcer (HP:0200042)1.80342181
153Stillbirth (HP:0003826)1.79639476
154Abnormal cartilage morphology (HP:0002763)1.78586553
155Polygenic inheritance (HP:0010982)1.78409836
156Vertigo (HP:0002321)1.78121335
157Mediastinal lymphadenopathy (HP:0100721)1.77445351
158Hemoptysis (HP:0002105)1.77138332
159Hepatosplenomegaly (HP:0001433)1.77091204
160Glomerulonephritis (HP:0000099)1.76294788
161Pulmonary artery stenosis (HP:0004415)1.74346185
162Abnormality of T cells (HP:0002843)1.73714924
163Osteoarthritis (HP:0002758)1.72792304
164Lumbar hyperlordosis (HP:0002938)1.72348255
165Joint stiffness (HP:0001387)1.71553298
166Short femoral neck (HP:0100864)1.70758158
167Purpura (HP:0000979)1.70203995
168Abnormality of the heme biosynthetic pathway (HP:0010472)1.69514120
169Hypergammaglobulinemia (HP:0010702)1.68987372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.27625218
2KDR3.15319316
3MAP3K33.09500853
4PRPF4B3.05869204
5RIPK42.95555049
6TGFBR22.56138389
7MST42.51517807
8MAP4K12.34312636
9ERN12.27513925
10TEC2.23349674
11MAP3K132.15717627
12NME22.10528213
13PIM22.06269053
14TXK2.06070542
15PDK22.02474036
16STK102.00240971
17CAMK1D1.86457161
18MAP2K31.85401674
19IRAK31.75906417
20LMTK21.73468841
21TRIB31.72492543
22STK241.72154106
23ZAP701.65309285
24TAOK31.62595234
25TRPM71.60719242
26TBK11.59111429
27IKBKE1.56507051
28BMPR21.55700262
29MAP3K141.54421807
30IRAK41.53730081
31MST1R1.52293432
32LRRK21.51036265
33MOS1.32997628
34VRK11.32652298
35MAPK121.29400216
36MAPKAPK31.27097286
37MYLK1.26623677
38MAP3K111.24873776
39JAK31.22807253
40DAPK21.20079449
41MAP3K11.19487101
42TAOK11.18309218
43MAPK151.17334773
44ILK1.16136905
45PHKG21.15633011
46PHKG11.15633011
47MATK1.11815658
48SIK11.11792027
49NLK1.10170617
50FGR1.10129828
51PIM11.09783250
52PRKG21.09156319
53BLK1.09145657
54EIF2AK31.09053708
55ITK1.07252450
56EIF2AK21.06972907
57DDR21.04625401
58RIPK10.98150678
59TNK20.97447258
60CAMKK10.95728256
61MAPK40.95232140
62ARAF0.94996280
63BTK0.91554226
64TAOK20.89955973
65TYRO30.89667044
66MARK30.89167827
67IRAK20.88908650
68IKBKB0.87738212
69CDC42BPA0.86141891
70BCKDK0.85902427
71TYK20.84369047
72PBK0.83807748
73PDK40.83148790
74PDK30.83148790
75TGFBR10.81964484
76FGFR30.81561939
77MARK20.80722416
78CSK0.80092149
79TESK10.79791771
80GRK10.79412055
81ERBB30.78161904
82TESK20.76398235
83SYK0.76302231
84HIPK20.76005585
85CAMK1G0.73080365
86PDK10.72877118
87LCK0.72778986
88CSF1R0.71778268
89NME10.71187155
90PDPK10.69623994
91MAPK70.69475849
92GRK60.68391679
93ABL20.66937517
94CDK90.65381579
95SIK30.65261627
96SGK30.63906028
97KIT0.62921001
98JAK10.62917503
99CHUK0.62805143
100CAMKK20.62703129
101IGF1R0.61721328
102RPS6KL10.61692497
103RPS6KC10.61692497
104EPHB10.60764151
105SGK20.60628507
106MAP2K20.58016530
107KSR20.56640425
108CLK10.52357284
109ADRBK20.52087388
110GSK3A0.51813585
111PRKAA20.51528610
112GRK70.51408047
113JAK20.51335650
114MUSK0.51247450
115RPS6KA60.51077538
116TTN0.50953546
117HCK0.50698441
118MAP3K50.49201011
119GRK50.48599669
120BMX0.47239100
121PDGFRB0.46829132
122EPHA30.46055610
123RPS6KA40.45760076
124MAP2K60.45710376
125CAMK40.45546722
126NEK90.45541789
127CASK0.44712499
128RPS6KA20.42577801
129CDK60.41634897
130TSSK60.41323193
131FES0.41076730
132ABL10.40977840
133FYN0.40752507
134PRKCQ0.40554117
135LYN0.40371201
136PIK3CA0.40256082
137PIK3CG0.40040386
138SGK2230.39889464
139SGK4940.39889464
140MAP3K120.39177692
141IRAK10.36390491
142MAP3K80.34621897
143MAPK30.30615025

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.96017163
2Fatty acid biosynthesis_Homo sapiens_hsa000612.72915679
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.51365171
4Malaria_Homo sapiens_hsa051442.43212129
5Staphylococcus aureus infection_Homo sapiens_hsa051502.21789085
6PPAR signaling pathway_Homo sapiens_hsa033202.19020521
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.15641623
8Primary immunodeficiency_Homo sapiens_hsa053402.06189618
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98878304
10Hematopoietic cell lineage_Homo sapiens_hsa046401.94966938
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83759222
12ECM-receptor interaction_Homo sapiens_hsa045121.83128989
13Leishmaniasis_Homo sapiens_hsa051401.82182822
14Autoimmune thyroid disease_Homo sapiens_hsa053201.78145224
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.77920369
16Type I diabetes mellitus_Homo sapiens_hsa049401.70812457
17Osteoclast differentiation_Homo sapiens_hsa043801.67664390
18Propanoate metabolism_Homo sapiens_hsa006401.65419127
19Pentose phosphate pathway_Homo sapiens_hsa000301.64947997
20Other glycan degradation_Homo sapiens_hsa005111.60736076
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.56808927
22Fatty acid metabolism_Homo sapiens_hsa012121.56278398
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.56016166
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.52081101
25Protein export_Homo sapiens_hsa030601.48750298
26Fatty acid degradation_Homo sapiens_hsa000711.45880894
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.45743672
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40763418
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39392635
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38447277
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36275804
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33991879
33Measles_Homo sapiens_hsa051621.30606229
34Sphingolipid metabolism_Homo sapiens_hsa006001.27560758
35Antigen processing and presentation_Homo sapiens_hsa046121.25186438
36Toxoplasmosis_Homo sapiens_hsa051451.22525336
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.21723205
38Chemokine signaling pathway_Homo sapiens_hsa040621.21347686
39Asthma_Homo sapiens_hsa053101.20304960
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17701295
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17059417
42Prion diseases_Homo sapiens_hsa050201.15401892
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15203051
44DNA replication_Homo sapiens_hsa030301.14177039
45Legionellosis_Homo sapiens_hsa051341.11321841
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09037331
47Collecting duct acid secretion_Homo sapiens_hsa049661.08612758
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00710314
49T cell receptor signaling pathway_Homo sapiens_hsa046600.98083748
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95746904
51Rheumatoid arthritis_Homo sapiens_hsa053230.95458292
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95420051
53HTLV-I infection_Homo sapiens_hsa051660.95095340
54Oxidative phosphorylation_Homo sapiens_hsa001900.94990115
55VEGF signaling pathway_Homo sapiens_hsa043700.93150632
56Small cell lung cancer_Homo sapiens_hsa052220.92885669
57Viral myocarditis_Homo sapiens_hsa054160.91765554
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91386401
59Apoptosis_Homo sapiens_hsa042100.90372133
60Lysosome_Homo sapiens_hsa041420.89804459
61Graft-versus-host disease_Homo sapiens_hsa053320.89428822
62TNF signaling pathway_Homo sapiens_hsa046680.89247859
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89043008
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87946335
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86813259
66Allograft rejection_Homo sapiens_hsa053300.85842097
67Focal adhesion_Homo sapiens_hsa045100.84857460
68Caffeine metabolism_Homo sapiens_hsa002320.83842856
69Thyroid cancer_Homo sapiens_hsa052160.83785136
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.83784427
71Protein digestion and absorption_Homo sapiens_hsa049740.82396762
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79641964
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.78759232
74Influenza A_Homo sapiens_hsa051640.78403367
75Parkinsons disease_Homo sapiens_hsa050120.78120064
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77874646
77Shigellosis_Homo sapiens_hsa051310.77504690
78HIF-1 signaling pathway_Homo sapiens_hsa040660.76617770
79Herpes simplex infection_Homo sapiens_hsa051680.76554664
80Hepatitis C_Homo sapiens_hsa051600.75363858
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.75241494
82Pertussis_Homo sapiens_hsa051330.74942328
83Renin-angiotensin system_Homo sapiens_hsa046140.74783184
84Renal cell carcinoma_Homo sapiens_hsa052110.74210999
85Arachidonic acid metabolism_Homo sapiens_hsa005900.72614473
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.69894615
87Glycerolipid metabolism_Homo sapiens_hsa005610.68509994
88Platelet activation_Homo sapiens_hsa046110.67842062
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67438036
90Carbon metabolism_Homo sapiens_hsa012000.67169796
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66708535
92Tuberculosis_Homo sapiens_hsa051520.66528737
93Phagosome_Homo sapiens_hsa041450.65455761
94Fatty acid elongation_Homo sapiens_hsa000620.64897900
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64422625
96Endocytosis_Homo sapiens_hsa041440.64148441
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64121529
98GnRH signaling pathway_Homo sapiens_hsa049120.63102938
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62939547
100MAPK signaling pathway_Homo sapiens_hsa040100.62536909
101Sulfur metabolism_Homo sapiens_hsa009200.62130825
102Insulin resistance_Homo sapiens_hsa049310.61905134
103Prolactin signaling pathway_Homo sapiens_hsa049170.60406699
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59490744
105Acute myeloid leukemia_Homo sapiens_hsa052210.58316829
106Sulfur relay system_Homo sapiens_hsa041220.57258533
107Chronic myeloid leukemia_Homo sapiens_hsa052200.56166949
108Base excision repair_Homo sapiens_hsa034100.55688760
109Systemic lupus erythematosus_Homo sapiens_hsa053220.55214973
110Synaptic vesicle cycle_Homo sapiens_hsa047210.53434288
111Pancreatic cancer_Homo sapiens_hsa052120.53324814
112Notch signaling pathway_Homo sapiens_hsa043300.52376813
113Glutathione metabolism_Homo sapiens_hsa004800.52134326
114Hepatitis B_Homo sapiens_hsa051610.51596457
115Circadian rhythm_Homo sapiens_hsa047100.50780639
116Amoebiasis_Homo sapiens_hsa051460.49789848
117Bladder cancer_Homo sapiens_hsa052190.49227321
118Non-small cell lung cancer_Homo sapiens_hsa052230.49002159
119Long-term potentiation_Homo sapiens_hsa047200.47733535
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47559854
121Salmonella infection_Homo sapiens_hsa051320.47296365
122Dorso-ventral axis formation_Homo sapiens_hsa043200.46355109
123Complement and coagulation cascades_Homo sapiens_hsa046100.46059834
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45809211
125Renin secretion_Homo sapiens_hsa049240.45663010
126African trypanosomiasis_Homo sapiens_hsa051430.45643668
127Type II diabetes mellitus_Homo sapiens_hsa049300.45605097
128B cell receptor signaling pathway_Homo sapiens_hsa046620.44751070
129Galactose metabolism_Homo sapiens_hsa000520.44584470
130Estrogen signaling pathway_Homo sapiens_hsa049150.43018099
131Huntingtons disease_Homo sapiens_hsa050160.42730721
132Proteasome_Homo sapiens_hsa030500.42336952
133N-Glycan biosynthesis_Homo sapiens_hsa005100.42311279
134Alzheimers disease_Homo sapiens_hsa050100.42093098
135Choline metabolism in cancer_Homo sapiens_hsa052310.41705958
136FoxO signaling pathway_Homo sapiens_hsa040680.41469087
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40998834
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40716022
139Mineral absorption_Homo sapiens_hsa049780.40371947
140Epstein-Barr virus infection_Homo sapiens_hsa051690.40053763
141Thyroid hormone synthesis_Homo sapiens_hsa049180.39619820
142Proteoglycans in cancer_Homo sapiens_hsa052050.39303955
143Rap1 signaling pathway_Homo sapiens_hsa040150.36880853
144Vibrio cholerae infection_Homo sapiens_hsa051100.36823292

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »