RGL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.43617441
2negative regulation of cell killing (GO:0031342)5.82275911
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.82275911
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.78370227
5leukocyte aggregation (GO:0070486)5.33337414
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.20925975
7antigen processing and presentation of endogenous antigen (GO:0019883)5.20779098
8neutrophil activation involved in immune response (GO:0002283)5.07996281
9regulation of B cell receptor signaling pathway (GO:0050855)5.01256378
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.80592076
11regulation of gamma-delta T cell differentiation (GO:0045586)4.80554440
12regulation of gamma-delta T cell activation (GO:0046643)4.79400210
13detection of other organism (GO:0098543)4.74125741
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.67068291
15detection of bacterium (GO:0016045)4.66007629
16modulation by symbiont of host defense response (GO:0052031)4.53498791
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.53498791
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.53498791
19positive regulation by organism of defense response of other organism involved in symbiotic interact4.53498791
20modulation by symbiont of host immune response (GO:0052553)4.53498791
21positive regulation by symbiont of host defense response (GO:0052509)4.53498791
22negative T cell selection (GO:0043383)4.51606297
23negative thymic T cell selection (GO:0045060)4.36613454
24positive regulation of B cell differentiation (GO:0045579)4.36475482
25positive thymic T cell selection (GO:0045059)4.35262682
26cellular extravasation (GO:0045123)4.27571407
27neutrophil activation (GO:0042119)4.16320300
28response to peptidoglycan (GO:0032494)4.10453049
29immunoglobulin mediated immune response (GO:0016064)4.07340131
30response to interleukin-15 (GO:0070672)4.03097796
31positive T cell selection (GO:0043368)3.99968977
32negative regulation of lymphocyte mediated immunity (GO:0002707)3.95947220
33leukocyte migration involved in inflammatory response (GO:0002523)3.95086844
34regulation of B cell differentiation (GO:0045577)3.93439567
35respiratory burst (GO:0045730)3.82877452
36detection of external biotic stimulus (GO:0098581)3.80084306
37B cell receptor signaling pathway (GO:0050853)3.78479038
38cellular response to interleukin-15 (GO:0071350)3.72222463
39regulation of mast cell degranulation (GO:0043304)3.72145060
40granulocyte activation (GO:0036230)3.69647909
41mast cell activation (GO:0045576)3.69507920
42macrophage activation involved in immune response (GO:0002281)3.64148074
43leukocyte degranulation (GO:0043299)3.64022697
44negative regulation of leukocyte mediated immunity (GO:0002704)3.63664491
45negative regulation of interleukin-12 production (GO:0032695)3.63573958
46myeloid cell activation involved in immune response (GO:0002275)3.63487676
47positive regulation of granulocyte differentiation (GO:0030854)3.62590331
48T cell selection (GO:0045058)3.61305973
49production of molecular mediator involved in inflammatory response (GO:0002532)3.61178149
50response to host immune response (GO:0052572)3.60213811
51response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.60213811
52negative regulation of T cell mediated immunity (GO:0002710)3.56089807
53thymic T cell selection (GO:0045061)3.52145735
54negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.48039165
55T cell migration (GO:0072678)3.44670669
56regulation of mast cell activation involved in immune response (GO:0033006)3.43826290
57Arp2/3 complex-mediated actin nucleation (GO:0034314)3.40050415
58regulation of interferon-beta biosynthetic process (GO:0045357)3.36796160
59detection of biotic stimulus (GO:0009595)3.36641294
60response to muramyl dipeptide (GO:0032495)3.35774634
61microglial cell activation (GO:0001774)3.35584575
62antigen processing and presentation via MHC class Ib (GO:0002475)3.34701205
63regulation of regulatory T cell differentiation (GO:0045589)3.32385527
64regulation of myeloid leukocyte mediated immunity (GO:0002886)3.30932538
65B cell mediated immunity (GO:0019724)3.30880060
66regulation of alpha-beta T cell proliferation (GO:0046640)3.29567668
67activated T cell proliferation (GO:0050798)3.29202801
68regulation of T cell tolerance induction (GO:0002664)3.26093274
69regulation of tolerance induction (GO:0002643)3.24628601
70regulation of T cell mediated cytotoxicity (GO:0001914)3.24041021
71response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23706961
72response to host (GO:0075136)3.23706961
73response to host defenses (GO:0052200)3.23706961
74positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23001720
75negative regulation of erythrocyte differentiation (GO:0045647)3.22864435
76negative regulation of phagocytosis (GO:0050765)3.21953976
77cellular response to type I interferon (GO:0071357)3.19010468
78type I interferon signaling pathway (GO:0060337)3.19010468
79regulation of mast cell activation (GO:0033003)3.17798533
80neutrophil mediated immunity (GO:0002446)3.16443344
81response to type I interferon (GO:0034340)3.16373502
82negative regulation of innate immune response (GO:0045824)3.10713371
83detection of molecule of bacterial origin (GO:0032490)3.10444079
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.10182385
85positive regulation of T cell mediated cytotoxicity (GO:0001916)3.08893523
86positive regulation of tolerance induction (GO:0002645)3.08680421
87regulation of leukocyte degranulation (GO:0043300)3.08229425
88tolerance induction (GO:0002507)3.06126943
89negative regulation of T-helper cell differentiation (GO:0045623)3.03462989
90negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.03462989
91antigen receptor-mediated signaling pathway (GO:0050851)3.02574836
92negative regulation of interleukin-6 production (GO:0032715)3.01779179
93regulation of natural killer cell mediated immunity (GO:0002715)2.99357928
94regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.99357928
95defense response to protozoan (GO:0042832)2.98349471
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91754574
97positive regulation of mast cell activation (GO:0033005)2.91652148
98NIK/NF-kappaB signaling (GO:0038061)2.91131583
99macrophage activation (GO:0042116)2.90141693
100mast cell activation involved in immune response (GO:0002279)2.89409108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.89204387
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.68199900
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.48903448
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.72210488
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.72124214
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.51756747
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.21105094
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.07747480
9RUNX_20019798_ChIP-Seq_JUKART_Human3.01860074
10SCL_19346495_ChIP-Seq_HPC-7_Human2.99753786
11MYB_26560356_Chip-Seq_TH2_Human2.93485311
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.86918954
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.83561533
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.82976908
15SPI1_23547873_ChIP-Seq_NB4_Human2.78166553
16VDR_21846776_ChIP-Seq_THP-1_Human2.77297984
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.68285486
18VDR_24763502_ChIP-Seq_THP-1_Human2.66030249
19MAF_26560356_Chip-Seq_TH1_Human2.60920588
20* UTX_26944678_Chip-Seq_JUKART_Human2.57592541
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49869422
22MYC_22102868_ChIP-Seq_BL_Human2.45056665
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.44363883
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40639608
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.39942969
26MYB_26560356_Chip-Seq_TH1_Human2.39414934
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35700159
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.35628251
29SPI1_23127762_ChIP-Seq_K562_Human2.34872091
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.31823185
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.22058398
32GATA3_27048872_Chip-Seq_THYMUS_Human2.05713324
33MAF_26560356_Chip-Seq_TH2_Human2.05666101
34BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01165073
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.00940162
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94815925
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.86108192
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80285210
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79246485
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77929411
41TCF7_22412390_ChIP-Seq_EML_Mouse1.76325682
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.76232356
43GATA3_26560356_Chip-Seq_TH2_Human1.69729512
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67819172
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56421792
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.53462627
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52403713
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.51909776
49* KDM2B_26808549_Chip-Seq_DND41_Human1.50975204
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50686581
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49488556
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48573564
53VDR_24787735_ChIP-Seq_THP-1_Human1.48059022
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47149292
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44078404
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41145627
57GATA1_19941826_ChIP-Seq_K562_Human1.38263755
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36267724
59BCL6_27268052_Chip-Seq_Bcells_Human1.35076348
60GATA1_22025678_ChIP-Seq_K562_Human1.34233747
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33986542
62CIITA_25753668_ChIP-Seq_RAJI_Human1.33566318
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31594273
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31578058
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29499739
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28294339
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27788828
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27559315
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24036140
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22772972
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22343822
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22238344
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21653757
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20980477
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20337647
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17990064
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14839342
78RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14794825
79BCOR_27268052_Chip-Seq_Bcells_Human1.12606415
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12295368
81PU_27001747_Chip-Seq_BMDM_Mouse1.11827784
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09053608
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.06352499
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.04495012
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04313608
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04158253
87SPI1_20517297_ChIP-Seq_HL60_Human1.02959715
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.02421025
89RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01387964
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.00736085
91GATA2_19941826_ChIP-Seq_K562_Human0.98360140
92LXR_22292898_ChIP-Seq_THP-1_Human0.96997951
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96871934
94* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95820633
95IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93238274
96GATA2_21666600_ChIP-Seq_HMVEC_Human0.92250848
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89893894
98P300_27268052_Chip-Seq_Bcells_Human0.89458074
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88499356
100NCOR1_26117541_ChIP-Seq_K562_Human0.85689254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.39690299
2MP0003436_decreased_susceptibility_to3.99061560
3MP0001835_abnormal_antigen_presentation3.96552924
4MP0005671_abnormal_response_to3.55120897
5MP0003763_abnormal_thymus_physiology3.25846054
6MP0005000_abnormal_immune_tolerance3.09157589
7MP0001800_abnormal_humoral_immune3.08278337
8MP0002419_abnormal_innate_immunity3.03417472
9MP0005025_abnormal_response_to3.00724801
10MP0003303_peritoneal_inflammation2.96607657
11MP0009785_altered_susceptibility_to2.91836763
12MP0000685_abnormal_immune_system2.87796007
13MP0002420_abnormal_adaptive_immunity2.77612759
14MP0002723_abnormal_immune_serum2.75474397
15MP0001819_abnormal_immune_cell2.73777021
16MP0001790_abnormal_immune_system2.67152112
17MP0005387_immune_system_phenotype2.67152112
18MP0002452_abnormal_antigen_presenting2.61431754
19MP0005464_abnormal_platelet_physiology2.47359723
20MP0002148_abnormal_hypersensitivity_rea2.32719465
21MP0002398_abnormal_bone_marrow2.31304743
22MP0009278_abnormal_bone_marrow2.22124406
23MP0002405_respiratory_system_inflammati2.18307460
24MP0000716_abnormal_immune_system2.17009812
25MP0002396_abnormal_hematopoietic_system2.04312673
26MP0006082_CNS_inflammation2.01380805
27MP0000465_gastrointestinal_hemorrhage1.98661624
28MP0001533_abnormal_skeleton_physiology1.96433417
29MP0002722_abnormal_immune_system1.90285313
30MP0003866_abnormal_defecation1.89921386
31MP0000689_abnormal_spleen_morphology1.88858292
32MP0009333_abnormal_splenocyte_physiolog1.88601747
33MP0002166_altered_tumor_susceptibility1.87611244
34MP0010155_abnormal_intestine_physiology1.84583156
35MP0000703_abnormal_thymus_morphology1.82831245
36MP0001845_abnormal_inflammatory_respons1.79257852
37MP0003172_abnormal_lysosome_physiology1.75522649
38MP0003191_abnormal_cellular_cholesterol1.75341444
39MP0002429_abnormal_blood_cell1.74999510
40MP0004947_skin_inflammation1.74786968
41MP0003300_gastrointestinal_ulcer1.71602664
42MP0005397_hematopoietic_system_phenotyp1.66631965
43MP0001545_abnormal_hematopoietic_system1.66631965
44MP0002132_abnormal_respiratory_system1.62913098
45MP0008260_abnormal_autophagy1.51650034
46MP0003828_pulmonary_edema1.44981569
47MP0005075_abnormal_melanosome_morpholog1.44701701
48MP0009764_decreased_sensitivity_to1.43768689
49MP0004381_abnormal_hair_follicle1.41878364
50MP0008469_abnormal_protein_level1.39274806
51MP0001851_eye_inflammation1.34123053
52MP0002009_preneoplasia1.31441925
53MP0002006_tumorigenesis1.26729295
54MP0000858_altered_metastatic_potential1.19323533
55MP0002933_joint_inflammation1.13983740
56MP0005310_abnormal_salivary_gland1.10722643
57MP0004808_abnormal_hematopoietic_stem1.10600679
58MP0003656_abnormal_erythrocyte_physiolo1.10565785
59MP0001873_stomach_inflammation1.10152005
60MP0002277_abnormal_respiratory_mucosa1.09151833
61MP0003183_abnormal_peptide_metabolism1.05424314
62MP0004883_abnormal_blood_vessel0.98278344
63MP0003075_altered_response_to0.96777204
64MP0002998_abnormal_bone_remodeling0.96660424
65MP0001853_heart_inflammation0.94901234
66MP0009763_increased_sensitivity_to0.92114622
67MP0001986_abnormal_taste_sensitivity0.88497199
68MP0005058_abnormal_lysosome_morphology0.88360625
69MP0008004_abnormal_stomach_pH0.85149072
70MP0002019_abnormal_tumor_incidence0.85133436
71MP0003045_fibrosis0.82379197
72MP0002138_abnormal_hepatobiliary_system0.81373724
73MP0005390_skeleton_phenotype0.80824335
74MP0003806_abnormal_nucleotide_metabolis0.80793967
75MP0000015_abnormal_ear_pigmentation0.79556310
76MP0001663_abnormal_digestive_system0.79178290
77MP0005166_decreased_susceptibility_to0.78821011
78MP0005164_abnormal_response_to0.77663875
79MP0003448_altered_tumor_morphology0.75959220
80MP0009765_abnormal_xenobiotic_induced0.74284417
81MP0000490_abnormal_crypts_of0.73429287
82MP0005451_abnormal_body_composition0.70986401
83MP0004130_abnormal_muscle_cell0.66766388
84MP0003795_abnormal_bone_structure0.62036955
85MP0008057_abnormal_DNA_replication0.60304642
86MP0003690_abnormal_glial_cell0.59088305
87MP0004510_myositis0.58075342
88MP0000249_abnormal_blood_vessel0.55367376
89MP0008874_decreased_physiological_sensi0.54056177
90MP0005174_abnormal_tail_pigmentation0.53063608
91MP0002693_abnormal_pancreas_physiology0.50135994
92MP0005376_homeostasis/metabolism_phenot0.48966592
93MP0008873_increased_physiological_sensi0.47130755
94MP0000604_amyloidosis0.46003314
95MP0000343_altered_response_to0.45053328
96MP0005535_abnormal_body_temperature0.44327384
97MP0000609_abnormal_liver_physiology0.43810109
98MP0005319_abnormal_enzyme/_coenzyme0.42675131
99MP0005083_abnormal_biliary_tract0.42520791
100MP0004185_abnormal_adipocyte_glucose0.41656963

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.11093058
2Recurrent abscess formation (HP:0002722)5.53658904
3Myositis (HP:0100614)5.38974774
4Stomatitis (HP:0010280)5.32908491
5Elevated erythrocyte sedimentation rate (HP:0003565)5.31298811
6Recurrent bacterial skin infections (HP:0005406)5.31270680
7Abnormality of macrophages (HP:0004311)4.78175534
8Orchitis (HP:0100796)4.71585762
9Optic neuritis (HP:0100653)4.56790423
10Retrobulbar optic neuritis (HP:0100654)4.56790423
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.53713953
12Recurrent fungal infections (HP:0002841)4.49418382
13Meningitis (HP:0001287)4.20718672
14Obstructive lung disease (HP:0006536)4.07625378
15Chronic obstructive pulmonary disease (HP:0006510)4.07625378
16Recurrent gram-negative bacterial infections (HP:0005420)4.02045562
17Encephalitis (HP:0002383)3.99630390
18Gastrointestinal infarctions (HP:0005244)3.97134024
19Mediastinal lymphadenopathy (HP:0100721)3.94150115
20T lymphocytopenia (HP:0005403)3.93223229
21Panhypogammaglobulinemia (HP:0003139)3.84444346
22Recurrent skin infections (HP:0001581)3.77307690
23Prolonged bleeding time (HP:0003010)3.77085543
24Abnormality of T cell number (HP:0011839)3.77000933
25Recurrent cutaneous fungal infections (HP:0011370)3.71353131
26Chronic mucocutaneous candidiasis (HP:0002728)3.71353131
27Increased IgE level (HP:0003212)3.65818210
28Keratoconjunctivitis sicca (HP:0001097)3.63965996
29Abnormality of T cells (HP:0002843)3.48300175
30Hypochromic microcytic anemia (HP:0004840)3.45266146
31Vasculitis (HP:0002633)3.40488602
32Keratoconjunctivitis (HP:0001096)3.39628481
33Cellulitis (HP:0100658)3.34470522
34Granulocytopenia (HP:0001913)3.28889050
35Spontaneous hematomas (HP:0007420)3.28325554
36Recurrent viral infections (HP:0004429)3.27102186
37Chest pain (HP:0100749)3.25936315
38Leukocytosis (HP:0001974)3.25556180
39Agammaglobulinemia (HP:0004432)3.22842517
40Urticaria (HP:0001025)3.22224446
41Inflammation of the large intestine (HP:0002037)3.18698227
42Epistaxis (HP:0000421)3.16188723
43Autoimmune hemolytic anemia (HP:0001890)3.11620171
44Hypochromic anemia (HP:0001931)3.10200757
45Gastrointestinal inflammation (HP:0004386)3.09910345
46Pustule (HP:0200039)3.08507583
47Episodic fever (HP:0001954)3.06158358
48Gingival bleeding (HP:0000225)3.03281429
49Severe combined immunodeficiency (HP:0004430)2.99777829
50Gingivitis (HP:0000230)2.98564612
51Increased IgM level (HP:0003496)2.94448140
52Pulmonary infiltrates (HP:0002113)2.90607551
53Abnormality of T cell physiology (HP:0011840)2.89421584
54Petechiae (HP:0000967)2.85247867
55Hemoptysis (HP:0002105)2.77720162
56Eosinophilia (HP:0001880)2.76341424
57Arterial thrombosis (HP:0004420)2.74758913
58Abnormality of the heme biosynthetic pathway (HP:0010472)2.70663006
59Anorexia (HP:0002039)2.70081606
60Abnormality of eosinophils (HP:0001879)2.65722293
61Colitis (HP:0002583)2.65513048
62Lymphopenia (HP:0001888)2.65393790
63Autoimmune thrombocytopenia (HP:0001973)2.57696505
64Hypergammaglobulinemia (HP:0010702)2.51709706
65Pulmonary embolism (HP:0002204)2.51085584
66Microcytic anemia (HP:0001935)2.50258636
67IgM deficiency (HP:0002850)2.49696499
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.48423530
69Sepsis (HP:0100806)2.47074672
70Osteomyelitis (HP:0002754)2.44343505
71Abnormality of the prostate (HP:0008775)2.40308298
72Abnormality of the pleura (HP:0002103)2.37700244
73IgG deficiency (HP:0004315)2.34254371
74Combined immunodeficiency (HP:0005387)2.30655900
75Abnormality of B cell number (HP:0010975)2.29674628
76Gangrene (HP:0100758)2.24464695
77Hepatosplenomegaly (HP:0001433)2.16386885
78Chronic otitis media (HP:0000389)2.14125256
79Papilloma (HP:0012740)2.13419796
80Verrucae (HP:0200043)2.13419796
81Abnormality of iron homeostasis (HP:0011031)2.13188531
82Joint swelling (HP:0001386)2.11604883
83Recurrent bronchitis (HP:0002837)2.11595185
84Stomach cancer (HP:0012126)2.11287150
85Peritonitis (HP:0002586)2.09931699
86Purpura (HP:0000979)2.09134302
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.08995048
88Increased serum ferritin (HP:0003281)2.08298859
89Skin rash (HP:0000988)2.06632048
90Skin ulcer (HP:0200042)2.04104086
91Increased cerebral lipofuscin (HP:0011813)2.00837743
92Acute hepatic failure (HP:0006554)2.00563218
93Slow saccadic eye movements (HP:0000514)2.00238085
94Chronic diarrhea (HP:0002028)1.99807707
95Vertigo (HP:0002321)1.98887447
96B lymphocytopenia (HP:0010976)1.97271375
97Glomerulopathy (HP:0100820)1.96787295
98Viral hepatitis (HP:0006562)1.96396191
99Prostate neoplasm (HP:0100787)1.95330189
100Increased neuronal autofluorescent lipopigment (HP:0002074)1.93564077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.42936584
2RIPK43.94666913
3FES2.97850847
4GRK62.81177881
5TXK2.78210585
6MAP2K32.70980441
7IRAK42.59607555
8TAOK32.57979435
9ZAP702.49672177
10TESK22.44025463
11TYK22.43527249
12BLK2.39745912
13BTK2.36997387
14TNK22.27286844
15CSK2.15572111
16SYK2.15568976
17MAP3K112.02147445
18IKBKE1.98051048
19ERN11.95604931
20MAP3K141.90480901
21KIT1.85381795
22HCK1.84096418
23PRPF4B1.83280506
24ITK1.79475727
25TEC1.78959716
26KDR1.78758036
27JAK31.78041808
28CSF1R1.60956131
29TBK11.54053244
30LYN1.50395441
31LCK1.48065051
32EPHB11.38101810
33JAK11.37880709
34TAOK11.29183900
35FGR1.25205155
36IKBKB1.16301345
37JAK21.15563032
38MAP3K31.11798263
39MARK31.11072957
40MAP3K131.04664619
41IRAK10.99822698
42PIK3CG0.96846650
43MAP3K10.90348611
44PRKCQ0.87545848
45MAP3K60.87527057
46TAOK20.87459899
47SIK30.85204538
48BMPR20.83264143
49MATK0.81328326
50PDK10.73795937
51BCKDK0.73228344
52MAP3K50.72603152
53PIM10.71687334
54SIK20.70072061
55CDK190.68018959
56MARK20.67702319
57MAP3K70.62971449
58MAP2K60.62384605
59FYN0.62357839
60STK100.62251486
61PRKD20.61339425
62SCYL20.59762832
63HIPK20.56031268
64IRAK20.56025770
65MAPK120.53174050
66EPHA30.52249743
67LRRK20.50816045
68MAP2K20.49338368
69NLK0.48277167
70YES10.46256151
71PTK60.45740202
72RET0.44492029
73MAPKAPK20.44171981
74PDPK10.43541344
75CAMKK10.43156989
76MAPK70.43122233
77RPS6KL10.43016137
78RPS6KC10.43016137
79MAPK110.42512092
80SMG10.40820665
81DAPK20.40604256
82PTK2B0.40581865
83CAMKK20.39431451
84FGFR30.39110607
85RPS6KA60.38925461
86DYRK1B0.38916403
87TRIB30.38301187
88CDK120.36607898
89CDK40.35655361
90MAP2K40.33094940
91KSR20.32569528
92FGFR40.31420865
93STK110.31329149
94ABL10.29230937
95MAPK30.28646612
96CLK10.26610967
97RAF10.25339711
98BMX0.25283861
99GRK70.25213151
100CDK60.24900203

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.70578337
2Leishmaniasis_Homo sapiens_hsa051402.95830541
3Osteoclast differentiation_Homo sapiens_hsa043802.75681997
4Graft-versus-host disease_Homo sapiens_hsa053322.69716896
5Allograft rejection_Homo sapiens_hsa053302.63218970
6Staphylococcus aureus infection_Homo sapiens_hsa051502.53393610
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.52807412
8Autoimmune thyroid disease_Homo sapiens_hsa053202.49389237
9B cell receptor signaling pathway_Homo sapiens_hsa046622.33169060
10Hematopoietic cell lineage_Homo sapiens_hsa046402.27300268
11T cell receptor signaling pathway_Homo sapiens_hsa046602.18970302
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.06557661
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03233560
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.03197549
15Measles_Homo sapiens_hsa051621.99514914
16Antigen processing and presentation_Homo sapiens_hsa046121.98035262
17Type I diabetes mellitus_Homo sapiens_hsa049401.97287593
18Malaria_Homo sapiens_hsa051441.95166723
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.94259385
20Tuberculosis_Homo sapiens_hsa051521.88052717
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83919334
22Asthma_Homo sapiens_hsa053101.75150702
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.71864458
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.69761492
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.68882946
26Acute myeloid leukemia_Homo sapiens_hsa052211.62743707
27Herpes simplex infection_Homo sapiens_hsa051681.60338949
28Viral myocarditis_Homo sapiens_hsa054161.53079500
29Legionellosis_Homo sapiens_hsa051341.45380778
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.44952539
31Chemokine signaling pathway_Homo sapiens_hsa040621.44266315
32Influenza A_Homo sapiens_hsa051641.43858714
33Platelet activation_Homo sapiens_hsa046111.42927872
34Toxoplasmosis_Homo sapiens_hsa051451.41255587
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39778754
36TNF signaling pathway_Homo sapiens_hsa046681.27790102
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21784785
38Shigellosis_Homo sapiens_hsa051311.20939681
39Non-small cell lung cancer_Homo sapiens_hsa052231.20701967
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18475282
41African trypanosomiasis_Homo sapiens_hsa051431.13611865
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12733565
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.09916811
44Other glycan degradation_Homo sapiens_hsa005111.08623301
45Hepatitis B_Homo sapiens_hsa051611.08492601
46Pertussis_Homo sapiens_hsa051331.01714755
47Phagosome_Homo sapiens_hsa041450.99356354
48Rheumatoid arthritis_Homo sapiens_hsa053230.99291710
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92510436
50Apoptosis_Homo sapiens_hsa042100.88811298
51Hepatitis C_Homo sapiens_hsa051600.88101842
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87251457
53Salmonella infection_Homo sapiens_hsa051320.86864627
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86518650
55Pancreatic cancer_Homo sapiens_hsa052120.82338668
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78976554
57Epstein-Barr virus infection_Homo sapiens_hsa051690.77078415
58Viral carcinogenesis_Homo sapiens_hsa052030.76519601
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71389320
60Chronic myeloid leukemia_Homo sapiens_hsa052200.70595070
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69686111
62VEGF signaling pathway_Homo sapiens_hsa043700.69401231
63Regulation of autophagy_Homo sapiens_hsa041400.68523707
64HTLV-I infection_Homo sapiens_hsa051660.64351633
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62352988
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.60887853
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60257160
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59993913
69Systemic lupus erythematosus_Homo sapiens_hsa053220.59805018
70Endocytosis_Homo sapiens_hsa041440.59669382
71Prolactin signaling pathway_Homo sapiens_hsa049170.58822967
72FoxO signaling pathway_Homo sapiens_hsa040680.55856705
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55723525
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55306351
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.53724096
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.51364668
77Lysosome_Homo sapiens_hsa041420.50928298
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.49897442
79Choline metabolism in cancer_Homo sapiens_hsa052310.44997147
80Insulin resistance_Homo sapiens_hsa049310.44323764
81Inositol phosphate metabolism_Homo sapiens_hsa005620.43479771
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41600842
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.41307331
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41094332
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40858817
86MAPK signaling pathway_Homo sapiens_hsa040100.39203519
87Amoebiasis_Homo sapiens_hsa051460.36469699
88Notch signaling pathway_Homo sapiens_hsa043300.32636653
89Renal cell carcinoma_Homo sapiens_hsa052110.30838843
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27911571
91Type II diabetes mellitus_Homo sapiens_hsa049300.26997700
92GnRH signaling pathway_Homo sapiens_hsa049120.26882716
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.26856818
94Colorectal cancer_Homo sapiens_hsa052100.26153206
95HIF-1 signaling pathway_Homo sapiens_hsa040660.25652609
96Endometrial cancer_Homo sapiens_hsa052130.25294388
97Dorso-ventral axis formation_Homo sapiens_hsa043200.24870996
98mTOR signaling pathway_Homo sapiens_hsa041500.24788127
99Arachidonic acid metabolism_Homo sapiens_hsa005900.24616501
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23789836

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