RGPD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* protein targeting to Golgi (GO:0000042)6.89059907
2* establishment of protein localization to Golgi (GO:0072600)6.79157578
3* retrograde transport, vesicle recycling within Golgi (GO:0000301)6.27508930
4* protein localization to Golgi apparatus (GO:0034067)5.28484303
5acrosome reaction (GO:0007340)4.97676793
6neural tube formation (GO:0001841)4.47912358
7piRNA metabolic process (GO:0034587)4.41484716
8histone H3-K9 demethylation (GO:0033169)4.21175309
9regulation of interleukin-12 biosynthetic process (GO:0045075)4.12903081
10histone mRNA catabolic process (GO:0071044)3.89696979
11DNA methylation involved in gamete generation (GO:0043046)3.87454584
12male meiosis I (GO:0007141)3.79128172
13response to pheromone (GO:0019236)3.73291960
14synapsis (GO:0007129)3.68723346
15male meiosis (GO:0007140)3.67653652
16* intra-Golgi vesicle-mediated transport (GO:0006891)3.62900116
17RNA destabilization (GO:0050779)3.58860077
18cilium or flagellum-dependent cell motility (GO:0001539)3.51350575
19positive regulation of granulocyte differentiation (GO:0030854)3.50346832
20sperm motility (GO:0030317)3.49732330
21single strand break repair (GO:0000012)3.44100876
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.39183606
23negative regulation of translation, ncRNA-mediated (GO:0040033)3.39183606
24regulation of translation, ncRNA-mediated (GO:0045974)3.39183606
25epithelial cilium movement (GO:0003351)3.35691149
26regulation of meiosis I (GO:0060631)3.26823700
27histamine secretion (GO:0001821)3.20078852
28centriole replication (GO:0007099)3.17920882
29histone H3-K9 methylation (GO:0051567)3.10944421
30monoubiquitinated protein deubiquitination (GO:0035520)3.07758576
31histone lysine demethylation (GO:0070076)3.05274511
32histone demethylation (GO:0016577)3.03922575
33neutrophil mediated immunity (GO:0002446)3.02714742
34negative regulation of NF-kappaB import into nucleus (GO:0042347)3.02263793
35pyrimidine nucleobase catabolic process (GO:0006208)3.01759093
36histone H3-K36 demethylation (GO:0070544)3.01709255
37myeloid leukocyte mediated immunity (GO:0002444)2.99579816
38positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.96893863
39mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.96893863
40positive regulation of gamma-delta T cell activation (GO:0046645)2.92996163
41regulation of B cell receptor signaling pathway (GO:0050855)2.90527972
42protein K63-linked deubiquitination (GO:0070536)2.88325451
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81916741
44negative regulation of B cell mediated immunity (GO:0002713)2.80331579
45negative regulation of immunoglobulin mediated immune response (GO:0002890)2.80331579
46peptidyl-lysine trimethylation (GO:0018023)2.80087503
47microtubule nucleation (GO:0007020)2.79324369
48negative regulation of B cell proliferation (GO:0030889)2.78940249
49regulation of sarcomere organization (GO:0060297)2.78496279
50regulation of gamma-delta T cell differentiation (GO:0045586)2.78293032
51protein demethylation (GO:0006482)2.77643958
52protein dealkylation (GO:0008214)2.77643958
53positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.74898755
54regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.74898755
55spermatid nucleus differentiation (GO:0007289)2.74616441
56histone H3-K9 modification (GO:0061647)2.72086034
57resolution of meiotic recombination intermediates (GO:0000712)2.71914120
58histone H3-K4 trimethylation (GO:0080182)2.71587118
59genitalia morphogenesis (GO:0035112)2.70667131
60protein deubiquitination (GO:0016579)2.67823300
61spermatid development (GO:0007286)2.67126470
62negative regulation of DNA recombination (GO:0045910)2.64402072
63protein polyglutamylation (GO:0018095)2.63489374
64multicellular organism reproduction (GO:0032504)2.62906729
65positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.62761744
66positive regulation of interleukin-2 production (GO:0032743)2.61770819
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.61650918
68Golgi to endosome transport (GO:0006895)2.61601928
69positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.59861575
70regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.59861575
71gene silencing by RNA (GO:0031047)2.58268934
72regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.58181941
73meiosis I (GO:0007127)2.57194409
74activated T cell proliferation (GO:0050798)2.56642523
75cilium movement (GO:0003341)2.56456676
76regulation of regulatory T cell differentiation (GO:0045589)2.54101535
77cellular response to interleukin-15 (GO:0071350)2.53175488
78protein modification by small protein removal (GO:0070646)2.53082250
79positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.52461964
80regulation of chemokine-mediated signaling pathway (GO:0070099)2.52283505
81CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.52032225
82T-helper cell differentiation (GO:0042093)2.52032225
83regulation of collateral sprouting (GO:0048670)2.51303088
84pyrimidine dimer repair (GO:0006290)2.50619895
85negative regulation of B cell activation (GO:0050869)2.49356717
86DNA double-strand break processing (GO:0000729)2.48907256
87positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.48353088
88response to interleukin-15 (GO:0070672)2.47684507
89positive regulation of T cell cytokine production (GO:0002726)2.47259708
90meiotic nuclear division (GO:0007126)2.47002944
91regulation of gamma-delta T cell activation (GO:0046643)2.45857158
92regulation of fibroblast apoptotic process (GO:2000269)2.43268341
93fucose catabolic process (GO:0019317)2.43054017
94L-fucose metabolic process (GO:0042354)2.43054017
95L-fucose catabolic process (GO:0042355)2.43054017
96regulation of cilium movement (GO:0003352)2.42929244
97negative regulation of inclusion body assembly (GO:0090084)2.42410979
98phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.42144390
99DNA integration (GO:0015074)2.41611192
100protein localization to cilium (GO:0061512)2.41193473

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human3.51164830
2ZNF274_21170338_ChIP-Seq_K562_Hela3.34396054
3POU3F2_20337985_ChIP-ChIP_501MEL_Human3.09394172
4TAF15_26573619_Chip-Seq_HEK293_Human2.93357541
5GBX2_23144817_ChIP-Seq_PC3_Human2.69698899
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.68934428
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.48890810
8FUS_26573619_Chip-Seq_HEK293_Human2.27602581
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.26252690
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.25919845
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22039639
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15572735
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14048168
14ER_23166858_ChIP-Seq_MCF-7_Human2.13025259
15VDR_22108803_ChIP-Seq_LS180_Human2.08652078
16P300_19829295_ChIP-Seq_ESCs_Human2.06851912
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91295858
18EWS_26573619_Chip-Seq_HEK293_Human1.84381481
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.81404552
20RUNX_20019798_ChIP-Seq_JUKART_Human1.81165187
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77436872
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.76394211
23POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.70702088
24TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70702088
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69665747
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66917710
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66007404
28CBP_20019798_ChIP-Seq_JUKART_Human1.66007404
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65493576
30STAT3_23295773_ChIP-Seq_U87_Human1.65433090
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59603355
32SMAD4_21799915_ChIP-Seq_A2780_Human1.56870205
33IRF1_19129219_ChIP-ChIP_H3396_Human1.56013821
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.52090918
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44439352
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43316893
37RUNX2_22187159_ChIP-Seq_PCA_Human1.42935086
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42899631
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.42486134
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42184470
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41333521
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41310174
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40814695
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40189058
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.40064001
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38979803
47PRDM14_20953172_ChIP-Seq_ESCs_Human1.38257596
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34803707
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34247652
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31814593
51AR_25329375_ChIP-Seq_VCAP_Human1.31057625
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.30941784
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29651640
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.28999577
55BCAT_22108803_ChIP-Seq_LS180_Human1.28425510
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27081265
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26257609
58TCF4_23295773_ChIP-Seq_U87_Human1.24807112
59MYB_26560356_Chip-Seq_TH2_Human1.24258898
60SALL4_22934838_ChIP-ChIP_CD34+_Human1.22711956
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.21748241
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21170359
63RNF2_27304074_Chip-Seq_NSC_Mouse1.20642143
64RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20538932
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19743398
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19419092
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19396959
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.18012799
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15747524
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14799014
71GATA3_27048872_Chip-Seq_THYMUS_Human1.14349126
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.14112361
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.13963641
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.13136658
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12756567
76TP53_22573176_ChIP-Seq_HFKS_Human1.12219568
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11202925
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11094062
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.10034654
80TCF4_22108803_ChIP-Seq_LS180_Human1.08648178
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08276847
82GATA3_26560356_Chip-Seq_TH2_Human1.08092751
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05489078
84TBL1_22424771_ChIP-Seq_293T_Human1.04099184
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.03438529
86ETV1_20927104_ChIP-Seq_GIST48_Human1.03250518
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03243899
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02626078
89SOX2_19829295_ChIP-Seq_ESCs_Human1.00007771
90NANOG_19829295_ChIP-Seq_ESCs_Human1.00007771
91EZH2_22144423_ChIP-Seq_EOC_Human0.99896549
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99878573
93P53_22387025_ChIP-Seq_ESCs_Mouse0.99363696
94TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.97602071
95CMYC_18555785_Chip-Seq_ESCs_Mouse0.96708485
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95439641
97VDR_24787735_ChIP-Seq_THP-1_Human0.95293450
98P300_18555785_Chip-Seq_ESCs_Mouse0.95247665
99NFYB_21822215_ChIP-Seq_K562_Human0.95138111
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94466797

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.81413611
2MP0002102_abnormal_ear_morphology3.68990863
3MP0002009_preneoplasia3.18570608
4MP0003195_calcinosis2.87229104
5MP0008057_abnormal_DNA_replication2.80476465
6MP0003724_increased_susceptibility_to2.80118880
7MP0000569_abnormal_digit_pigmentation2.77861009
8MP0003787_abnormal_imprinting2.71994654
9MP0003880_abnormal_central_pattern2.49464685
10MP0009697_abnormal_copulation2.38311502
11MP0005410_abnormal_fertilization2.25475964
12MP0003122_maternal_imprinting2.15110665
13MP0006276_abnormal_autonomic_nervous2.11705376
14MP0001929_abnormal_gametogenesis1.92874983
15MP0003698_abnormal_male_reproductive1.83705574
16MP0006054_spinal_hemorrhage1.82749101
17MP0004484_altered_response_of1.80716482
18MP0008995_early_reproductive_senescence1.76736170
19MP0009278_abnormal_bone_marrow1.70008247
20MP0006292_abnormal_olfactory_placode1.65407561
21MP0003221_abnormal_cardiomyocyte_apopto1.60376978
22MP0003763_abnormal_thymus_physiology1.59119496
23MP0003121_genomic_imprinting1.57765095
24MP0005248_abnormal_Harderian_gland1.56926747
25MP0002653_abnormal_ependyma_morphology1.50711380
26MP0005499_abnormal_olfactory_system1.47149871
27MP0005394_taste/olfaction_phenotype1.47149871
28MP0005377_hearing/vestibular/ear_phenot1.39925975
29MP0003878_abnormal_ear_physiology1.39925975
30MP0001486_abnormal_startle_reflex1.39554098
31MP0002210_abnormal_sex_determination1.39429651
32MP0005671_abnormal_response_to1.37439465
33MP0008789_abnormal_olfactory_epithelium1.34536059
34MP0005397_hematopoietic_system_phenotyp1.34525209
35MP0001545_abnormal_hematopoietic_system1.34525209
36MP0005167_abnormal_blood-brain_barrier1.32639416
37MP0002127_abnormal_cardiovascular_syste1.31368494
38MP0002928_abnormal_bile_duct1.27147525
39MP0002138_abnormal_hepatobiliary_system1.27107680
40MP0005423_abnormal_somatic_nervous1.25424454
41MP0005253_abnormal_eye_physiology1.24209095
42MP0001800_abnormal_humoral_immune1.23669567
43MP0002254_reproductive_system_inflammat1.21873749
44MP0000653_abnormal_sex_gland1.19525684
45MP0002132_abnormal_respiratory_system1.16091989
46MP0009764_decreased_sensitivity_to1.15613403
47MP0001145_abnormal_male_reproductive1.13925088
48MP0001984_abnormal_olfaction1.11047322
49MP0001529_abnormal_vocalization1.09347481
50MP0004742_abnormal_vestibular_system1.07686571
51MP0003646_muscle_fatigue1.06588005
52MP0002723_abnormal_immune_serum1.05550352
53MP0002638_abnormal_pupillary_reflex1.01915854
54MP0002166_altered_tumor_susceptibility1.01694930
55MP0003567_abnormal_fetal_cardiomyocyte0.98236637
56MP0002420_abnormal_adaptive_immunity0.97408333
57MP0000631_abnormal_neuroendocrine_gland0.96456019
58MP0001819_abnormal_immune_cell0.95705105
59MP0003890_abnormal_embryonic-extraembry0.94798042
60MP0005171_absent_coat_pigmentation0.93381763
61MP0000778_abnormal_nervous_system0.91375178
62MP0000703_abnormal_thymus_morphology0.90865467
63MP0000465_gastrointestinal_hemorrhage0.89758088
64MP0004215_abnormal_myocardial_fiber0.89276625
65MP0000689_abnormal_spleen_morphology0.88934429
66MP0002398_abnormal_bone_marrow0.88360014
67MP0000372_irregular_coat_pigmentation0.87602144
68MP0003303_peritoneal_inflammation0.86122750
69MP0005000_abnormal_immune_tolerance0.85894260
70MP0002751_abnormal_autonomic_nervous0.85512638
71MP0001188_hyperpigmentation0.83599242
72MP0005645_abnormal_hypothalamus_physiol0.83359311
73MP0002452_abnormal_antigen_presenting0.83146643
74MP0002722_abnormal_immune_system0.82402774
75MP0003252_abnormal_bile_duct0.79739773
76MP0002006_tumorigenesis0.79524003
77MP0000716_abnormal_immune_system0.77374949
78MP0008004_abnormal_stomach_pH0.76813288
79MP0002161_abnormal_fertility/fecundity0.76586765
80MP0005075_abnormal_melanosome_morpholog0.76480328
81MP0002405_respiratory_system_inflammati0.76070398
82MP0001119_abnormal_female_reproductive0.75530083
83MP0005310_abnormal_salivary_gland0.75318013
84MP0006072_abnormal_retinal_apoptosis0.74147163
85MP0000427_abnormal_hair_cycle0.73751270
86MP0002822_catalepsy0.73562244
87MP0001293_anophthalmia0.73074054
88MP0002419_abnormal_innate_immunity0.73040538
89MP0009785_altered_susceptibility_to0.72755598
90MP0001501_abnormal_sleep_pattern0.66922308
91MP0005551_abnormal_eye_electrophysiolog0.66594448
92MP0000383_abnormal_hair_follicle0.66495389
93MP0001502_abnormal_circadian_rhythm0.65761462
94MP0001835_abnormal_antigen_presentation0.65448844
95MP0001919_abnormal_reproductive_system0.64715875
96MP0003828_pulmonary_edema0.64476557
97MP0005187_abnormal_penis_morphology0.64362610
98MP0004133_heterotaxia0.64273418
99MP0004883_abnormal_blood_vessel0.63864376
100MP0003436_decreased_susceptibility_to0.62261553

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)4.01749841
2Stomatitis (HP:0010280)3.43677431
3Pancreatic cysts (HP:0001737)3.43277928
4Medial flaring of the eyebrow (HP:0010747)3.26555011
5Stomach cancer (HP:0012126)3.16898711
6T lymphocytopenia (HP:0005403)3.07183908
7Chronic hepatic failure (HP:0100626)3.04401799
8Pancreatic fibrosis (HP:0100732)2.99130165
9Abnormality of T cell number (HP:0011839)2.90806039
10Hypochromic microcytic anemia (HP:0004840)2.86228981
11Thyroiditis (HP:0100646)2.82207962
12Congenital primary aphakia (HP:0007707)2.76310021
13Nephronophthisis (HP:0000090)2.76279892
14Hypothermia (HP:0002045)2.76225888
15True hermaphroditism (HP:0010459)2.73961246
16Gait imbalance (HP:0002141)2.70975793
17Abnormality of the renal medulla (HP:0100957)2.68395963
18Attenuation of retinal blood vessels (HP:0007843)2.64783550
19Severe combined immunodeficiency (HP:0004430)2.62807674
20Amyotrophic lateral sclerosis (HP:0007354)2.61198746
21Nephrogenic diabetes insipidus (HP:0009806)2.56364038
22Truncal obesity (HP:0001956)2.45576814
23Poor coordination (HP:0002370)2.37360496
24Genital tract atresia (HP:0001827)2.35385266
25Abnormality of eosinophils (HP:0001879)2.31186286
26Vaginal atresia (HP:0000148)2.29009692
27Leukocytosis (HP:0001974)2.27243591
28Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.26900151
29Papillary thyroid carcinoma (HP:0002895)2.24935484
30Gonadotropin excess (HP:0000837)2.23548374
31Progressive cerebellar ataxia (HP:0002073)2.23221912
32Absent/shortened dynein arms (HP:0200106)2.21536048
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.21536048
34Abnormal hair whorl (HP:0010721)2.19805636
35Abnormality of the renal cortex (HP:0011035)2.19777559
36Atonic seizures (HP:0010819)2.19342430
37Absent speech (HP:0001344)2.19262465
38Genetic anticipation (HP:0003743)2.18967526
39Drooling (HP:0002307)2.17296782
40Neoplasm of the tracheobronchial system (HP:0100552)2.12932444
41Abnormal respiratory epithelium morphology (HP:0012253)2.11551792
42Abnormal respiratory motile cilium morphology (HP:0005938)2.11551792
43Anencephaly (HP:0002323)2.11535863
44Excessive salivation (HP:0003781)2.10884206
45Panhypogammaglobulinemia (HP:0003139)2.09664546
46Spontaneous hematomas (HP:0007420)2.03426323
47Tubulointerstitial abnormality (HP:0001969)2.02093415
48Oligodactyly (hands) (HP:0001180)2.00886684
49Abnormality of T cells (HP:0002843)2.00454157
50Gaze-evoked nystagmus (HP:0000640)1.99097098
51Bony spicule pigmentary retinopathy (HP:0007737)1.99002041
52Rimmed vacuoles (HP:0003805)1.98226183
53Eosinophilia (HP:0001880)1.97661251
54Volvulus (HP:0002580)1.94862652
55Combined immunodeficiency (HP:0005387)1.92793637
56Alveolar cell carcinoma (HP:0006519)1.92107628
57Stenosis of the external auditory canal (HP:0000402)1.91909324
58Cystic liver disease (HP:0006706)1.91590097
59Abnormal ciliary motility (HP:0012262)1.91551819
60Vitreoretinal degeneration (HP:0000655)1.90066336
61Specific learning disability (HP:0001328)1.89201131
62Supernumerary spleens (HP:0009799)1.89159619
63Febrile seizures (HP:0002373)1.87244167
64Abnormal rod and cone electroretinograms (HP:0008323)1.87231406
65Hypoplasia of the thymus (HP:0000778)1.87112190
66Abnormal delayed hypersensitivity skin test (HP:0002963)1.86779519
67Intestinal atresia (HP:0011100)1.86611273
68Abnormal respiratory motile cilium physiology (HP:0012261)1.85274373
69Broad foot (HP:0001769)1.81974201
70Abnormality of B cell number (HP:0010975)1.81351953
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.80907399
72Congenital hepatic fibrosis (HP:0002612)1.78331506
73Retrobulbar optic neuritis (HP:0100654)1.76544839
74Optic neuritis (HP:0100653)1.76544839
75Chronic diarrhea (HP:0002028)1.76408171
76Postaxial foot polydactyly (HP:0001830)1.76380973
77Menstrual irregularities (HP:0000858)1.75268572
78Thyroid carcinoma (HP:0002890)1.75141033
79Decreased testicular size (HP:0008734)1.74107706
80Bladder carcinoma (HP:0002862)1.71471743
81Bladder neoplasm (HP:0009725)1.71471743
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70789697
83Rhabdomyosarcoma (HP:0002859)1.69030847
84Biliary tract neoplasm (HP:0100574)1.68269760
85Occipital encephalocele (HP:0002085)1.67471125
86Hypoplastic iliac wings (HP:0002866)1.66633892
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66594362
88Degeneration of the lateral corticospinal tracts (HP:0002314)1.66594362
89Hematochezia (HP:0002573)1.65226014
90Colon cancer (HP:0003003)1.64630736
91Abdominal situs inversus (HP:0003363)1.64623051
92Abnormality of abdominal situs (HP:0011620)1.64623051
93Severe visual impairment (HP:0001141)1.63578724
94Abnormality of the lower motor neuron (HP:0002366)1.63453360
95Postaxial hand polydactyly (HP:0001162)1.62450532
96Asplenia (HP:0001746)1.61506086
97Aplasia/Hypoplasia of the spleen (HP:0010451)1.61468988
98Abnormality of the prostate (HP:0008775)1.61454928
99Dyskinesia (HP:0100660)1.57578987
100Decreased central vision (HP:0007663)1.57433991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K43.64933762
2TXK3.33920056
3BRD43.32470280
4WNK32.67757579
5MAP2K72.38944682
6TAOK32.35449151
7BCR2.21229443
8ERBB32.19652183
9FRK2.10756750
10EPHA32.03270499
11MAP4K21.97713283
12TRIM281.90669177
13ACVR1B1.88587735
14BMPR1B1.86387291
15TNIK1.84920611
16CDK191.70686803
17IRAK11.70584651
18MKNK21.67213270
19PLK41.59051532
20NLK1.49407836
21IRAK41.43518509
22MKNK11.42473669
23PLK21.39886851
24DYRK31.38724787
25PKN21.28867352
26BLK1.20015236
27SRPK11.17975464
28NUAK11.16370269
29TEC1.10213098
30RPS6KA41.09409479
31MAP2K41.08934561
32ITK1.08885374
33SGK21.07730457
34AKT31.02488456
35CASK1.00050258
36STK38L0.99210329
37CAMK1G0.97837713
38GRK70.94135319
39SIK30.92425604
40DYRK1B0.92342840
41JAK20.91506666
42PINK10.90313710
43IKBKE0.89788720
44TNK20.89589399
45FLT30.87029246
46BTK0.86188068
47PAK30.86056422
48MAP3K60.85261291
49RET0.81207755
50SYK0.75746923
51MAPK130.75224768
52CAMK40.74654455
53SGK4940.73989663
54SGK2230.73989663
55CSK0.73681335
56OBSCN0.73356749
57CAMK1D0.72983045
58FES0.72882732
59MAP3K50.72723754
60BMPR20.71359329
61KSR10.70500932
62LATS10.69986728
63MAP4K10.69715866
64CSNK1G20.69539661
65ZAK0.69163529
66FGR0.66377355
67HCK0.66071385
68LCK0.64862959
69MARK10.64292289
70YES10.63843178
71WNK10.62389336
72DYRK1A0.60862176
73PRKCQ0.59597388
74DYRK20.58808910
75ADRBK20.58718555
76OXSR10.58694140
77INSRR0.58437355
78MAP3K70.58384634
79CHUK0.57378855
80FER0.57232861
81MAP3K20.56135875
82EGFR0.55917086
83CSNK1G30.55658078
84CSNK1G10.55402238
85CSNK1A1L0.54748813
86STK380.53618224
87MARK30.53421224
88EIF2AK30.53381485
89LYN0.53201687
90PIK3CG0.51670369
91PNCK0.51654036
92PTK2B0.48245237
93IRAK20.47760460
94GRK10.47103276
95GRK60.46335270
96CDK60.46082777
97JAK30.46069166
98NTRK20.43740948
99STK30.43587141
100IKBKB0.43541423

Predicted pathways (KEGG)

RankGene SetZ-score
1NOD-like receptor signaling pathway_Homo sapiens_hsa046212.48849079
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34822287
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.28095409
4Primary immunodeficiency_Homo sapiens_hsa053402.18987900
5T cell receptor signaling pathway_Homo sapiens_hsa046602.07513281
6Dorso-ventral axis formation_Homo sapiens_hsa043201.87611054
7RNA degradation_Homo sapiens_hsa030181.81600614
8Regulation of autophagy_Homo sapiens_hsa041401.76551007
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73909932
10Legionellosis_Homo sapiens_hsa051341.72307172
11Circadian rhythm_Homo sapiens_hsa047101.70477523
12Olfactory transduction_Homo sapiens_hsa047401.64563513
13Butanoate metabolism_Homo sapiens_hsa006501.61102123
14Nicotine addiction_Homo sapiens_hsa050331.59992280
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58513925
16Basal transcription factors_Homo sapiens_hsa030221.57009813
17Taste transduction_Homo sapiens_hsa047421.56064853
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48922443
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45706082
20Type II diabetes mellitus_Homo sapiens_hsa049301.45322853
21Measles_Homo sapiens_hsa051621.40014237
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.38828232
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35035714
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.32919577
25mRNA surveillance pathway_Homo sapiens_hsa030151.31988046
26Osteoclast differentiation_Homo sapiens_hsa043801.31271136
27Phototransduction_Homo sapiens_hsa047441.27149966
28* RNA transport_Homo sapiens_hsa030131.25202772
29Linoleic acid metabolism_Homo sapiens_hsa005911.24320692
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22071827
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.18667931
32Fanconi anemia pathway_Homo sapiens_hsa034601.17571029
33Colorectal cancer_Homo sapiens_hsa052101.14908979
34Serotonergic synapse_Homo sapiens_hsa047261.14661854
35Fatty acid biosynthesis_Homo sapiens_hsa000611.12711301
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12414311
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10130521
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09439529
39Morphine addiction_Homo sapiens_hsa050321.06450923
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06428099
41Prolactin signaling pathway_Homo sapiens_hsa049171.06075860
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05987508
43TNF signaling pathway_Homo sapiens_hsa046681.05964923
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01890607
45FoxO signaling pathway_Homo sapiens_hsa040681.00198011
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96553567
47Propanoate metabolism_Homo sapiens_hsa006400.96239218
48Inositol phosphate metabolism_Homo sapiens_hsa005620.94973024
49GABAergic synapse_Homo sapiens_hsa047270.94109678
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92649264
51Oocyte meiosis_Homo sapiens_hsa041140.90749939
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89743236
53Chemokine signaling pathway_Homo sapiens_hsa040620.85463826
54Hepatitis B_Homo sapiens_hsa051610.85062963
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84075078
56Ether lipid metabolism_Homo sapiens_hsa005650.83022428
57Hematopoietic cell lineage_Homo sapiens_hsa046400.80538012
58Acute myeloid leukemia_Homo sapiens_hsa052210.78953281
59HIF-1 signaling pathway_Homo sapiens_hsa040660.75905341
60Long-term depression_Homo sapiens_hsa047300.74280225
61Glutamatergic synapse_Homo sapiens_hsa047240.73995855
62MAPK signaling pathway_Homo sapiens_hsa040100.73204799
63ABC transporters_Homo sapiens_hsa020100.72111699
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71476341
65Choline metabolism in cancer_Homo sapiens_hsa052310.70760193
66Malaria_Homo sapiens_hsa051440.70600802
67B cell receptor signaling pathway_Homo sapiens_hsa046620.68214232
68Cholinergic synapse_Homo sapiens_hsa047250.67621614
69Dopaminergic synapse_Homo sapiens_hsa047280.67528944
70Circadian entrainment_Homo sapiens_hsa047130.67239172
71Tuberculosis_Homo sapiens_hsa051520.66548714
72Herpes simplex infection_Homo sapiens_hsa051680.65246346
73Leishmaniasis_Homo sapiens_hsa051400.64149590
74Ras signaling pathway_Homo sapiens_hsa040140.61566201
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58954971
76cAMP signaling pathway_Homo sapiens_hsa040240.58898457
77Cocaine addiction_Homo sapiens_hsa050300.58429023
78Viral carcinogenesis_Homo sapiens_hsa052030.56942380
79Endometrial cancer_Homo sapiens_hsa052130.56865050
80mTOR signaling pathway_Homo sapiens_hsa041500.56754170
81Nitrogen metabolism_Homo sapiens_hsa009100.56191089
82Influenza A_Homo sapiens_hsa051640.56087203
83Protein export_Homo sapiens_hsa030600.55165325
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54391936
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54333256
86Axon guidance_Homo sapiens_hsa043600.52201783
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52143137
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51758173
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.50990643
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50926567
91Non-small cell lung cancer_Homo sapiens_hsa052230.50825286
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.49929445
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48639198
94Steroid biosynthesis_Homo sapiens_hsa001000.47055667
95Prostate cancer_Homo sapiens_hsa052150.45917154
96Shigellosis_Homo sapiens_hsa051310.42944772
97Spliceosome_Homo sapiens_hsa030400.41562094
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.40853750
99Salmonella infection_Homo sapiens_hsa051320.40801782
100Amphetamine addiction_Homo sapiens_hsa050310.38753098

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