RGPD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located in a cluster of Ran-binding protein related genes on chromosome 2 which arose through duplication in primates. The encoded protein contains an N-terminal TPR (tetratricopeptide repeat) domain, two Ran-binding domains, and a C-terminal GRIP domain (golgin-97, RanBP2alpha, Imh1p and p230/golgin-245) domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.04703236
2protein polyglutamylation (GO:0018095)8.26909793
3* protein targeting to Golgi (GO:0000042)8.17895589
4fusion of sperm to egg plasma membrane (GO:0007342)8.15098962
5* establishment of protein localization to Golgi (GO:0072600)7.99960981
6* retrograde transport, vesicle recycling within Golgi (GO:0000301)7.48795690
7rRNA methylation (GO:0031167)7.38538520
8single strand break repair (GO:0000012)7.37698337
9spermatid development (GO:0007286)6.83596994
10microtubule depolymerization (GO:0007019)6.82225133
11response to pheromone (GO:0019236)6.78465104
12centriole replication (GO:0007099)6.68665921
13microtubule polymerization or depolymerization (GO:0031109)6.35293682
14rRNA modification (GO:0000154)6.28598806
15DNA packaging (GO:0006323)6.28407375
16chromosome condensation (GO:0030261)6.27710156
17sperm capacitation (GO:0048240)6.23784265
18plasma membrane fusion (GO:0045026)6.23250966
19multicellular organism reproduction (GO:0032504)6.13803535
20sperm-egg recognition (GO:0035036)6.09092760
21* protein localization to Golgi apparatus (GO:0034067)6.01205036
22seminiferous tubule development (GO:0072520)5.92655847
23phosphatidylethanolamine biosynthetic process (GO:0006646)5.85862227
24spermatogenesis (GO:0007283)5.84616652
25spermatid nucleus differentiation (GO:0007289)5.84375722
26male gamete generation (GO:0048232)5.83182686
27regulation of centriole replication (GO:0046599)5.78883116
28cilium or flagellum-dependent cell motility (GO:0001539)5.74098099
29microtubule severing (GO:0051013)5.72609457
30regulation of cilium movement (GO:0003352)5.70624667
31centriole assembly (GO:0098534)5.58301970
32axonemal dynein complex assembly (GO:0070286)5.51914414
33epithelial cilium movement (GO:0003351)5.44108046
34phosphatidylethanolamine metabolic process (GO:0046337)5.40363953
35gamete generation (GO:0007276)5.39622545
36calcium ion-dependent exocytosis (GO:0017156)5.28921924
37reproduction (GO:0000003)5.22916652
38binding of sperm to zona pellucida (GO:0007339)5.19351758
39RNA destabilization (GO:0050779)5.07257885
40cell-cell recognition (GO:0009988)5.00869222
41single fertilization (GO:0007338)4.88072575
42cilium movement (GO:0003341)4.66062066
43piRNA metabolic process (GO:0034587)4.55245804
44regulation of meiosis I (GO:0060631)4.54761542
45cellular ketone body metabolic process (GO:0046950)4.53929745
46fertilization (GO:0009566)4.41932742
47motile cilium assembly (GO:0044458)4.32913411
48multicellular organismal reproductive process (GO:0048609)4.28103521
49cell wall macromolecule catabolic process (GO:0016998)4.21742478
50germ cell development (GO:0007281)4.17554946
51glomerular visceral epithelial cell development (GO:0072015)4.15945886
52axoneme assembly (GO:0035082)4.05961797
53ketone body metabolic process (GO:1902224)3.98983358
54cell wall macromolecule metabolic process (GO:0044036)3.98421192
55microtubule nucleation (GO:0007020)3.85940839
56multicellular organismal movement (GO:0050879)3.80608550
57musculoskeletal movement (GO:0050881)3.80608550
58glomerular epithelial cell development (GO:0072310)3.80259195
59regulation of transcription involved in cell fate commitment (GO:0060850)3.78241577
60negative regulation of inclusion body assembly (GO:0090084)3.77245491
61cellular process involved in reproduction in multicellular organism (GO:0022412)3.76970940
62male meiosis (GO:0007140)3.72256022
63regulation of microtubule-based movement (GO:0060632)3.70571308
64male meiosis I (GO:0007141)3.68928605
65regulation of Rab GTPase activity (GO:0032313)3.63263246
66positive regulation of Rab GTPase activity (GO:0032851)3.63263246
67DNA methylation involved in gamete generation (GO:0043046)3.57679450
68sexual reproduction (GO:0019953)3.57052913
69* intra-Golgi vesicle-mediated transport (GO:0006891)3.43008103
70nucleus organization (GO:0006997)3.41695049
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.39551243
72organic cation transport (GO:0015695)3.34067865
73histone mRNA catabolic process (GO:0071044)3.30758234
74glycerol ether metabolic process (GO:0006662)3.25401197
75acrosome assembly (GO:0001675)3.17582184
76synapsis (GO:0007129)3.16174869
77nuclear pore complex assembly (GO:0051292)3.09171145
78cilium organization (GO:0044782)3.03735613
79coenzyme catabolic process (GO:0009109)3.02219902
80ether metabolic process (GO:0018904)3.01911559
81cilium assembly (GO:0042384)3.01083515
82peptidyl-glutamic acid modification (GO:0018200)2.91256132
83ventricular system development (GO:0021591)2.89858859
84membrane protein intracellular domain proteolysis (GO:0031293)2.87472508
85regulation of hexokinase activity (GO:1903299)2.87264053
86regulation of glucokinase activity (GO:0033131)2.87264053
87detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.82856725
88spinal cord motor neuron differentiation (GO:0021522)2.79409640
89left/right axis specification (GO:0070986)2.72841626
90vesicle transport along microtubule (GO:0047496)2.71235197
91meiosis I (GO:0007127)2.70106578
92multicellular organismal development (GO:0007275)2.69155424
93mitochondrial fission (GO:0000266)2.65210376
94regulation of centrosome duplication (GO:0010824)2.59547666
95polyamine biosynthetic process (GO:0006596)2.56754105
96positive regulation of meiosis (GO:0045836)2.55822778
97alanine transport (GO:0032328)2.54818143
98Golgi to endosome transport (GO:0006895)2.54022105
99positive regulation of guanylate cyclase activity (GO:0031284)2.53686247
100sperm motility (GO:0030317)10.6267394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.59106615
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.42765608
3FUS_26573619_Chip-Seq_HEK293_Human2.88662950
4ZNF274_21170338_ChIP-Seq_K562_Hela2.62295483
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.53039646
6CBP_20019798_ChIP-Seq_JUKART_Human2.46937575
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.46937575
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.46337446
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30904169
10GBX2_23144817_ChIP-Seq_PC3_Human2.30753279
11VDR_22108803_ChIP-Seq_LS180_Human2.21675158
12P300_19829295_ChIP-Seq_ESCs_Human2.15412740
13TAF15_26573619_Chip-Seq_HEK293_Human2.11408912
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11163450
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.11163450
16ER_23166858_ChIP-Seq_MCF-7_Human2.10241772
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09251505
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02083184
19UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.00871126
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96893845
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86565352
22* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.79067293
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.72389506
24* SMAD3_21741376_ChIP-Seq_EPCs_Human1.72079645
25SMAD4_21799915_ChIP-Seq_A2780_Human1.71839977
26EZH2_22144423_ChIP-Seq_EOC_Human1.69259984
27* AR_25329375_ChIP-Seq_VCAP_Human1.68949142
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67523434
29STAT3_23295773_ChIP-Seq_U87_Human1.62805484
30SOX2_19829295_ChIP-Seq_ESCs_Human1.62615872
31NANOG_19829295_ChIP-Seq_ESCs_Human1.62615872
32* SMAD4_21741376_ChIP-Seq_EPCs_Human1.61075559
33IGF1R_20145208_ChIP-Seq_DFB_Human1.59794561
34AUTS2_25519132_ChIP-Seq_293T-REX_Human1.58274822
35TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52365695
36FOXA1_21572438_ChIP-Seq_LNCaP_Human1.51750450
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.49582872
38KLF5_20875108_ChIP-Seq_MESCs_Mouse1.47946188
39MYC_19829295_ChIP-Seq_ESCs_Human1.47776932
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47711058
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43251318
42* RBPJ_21746931_ChIP-Seq_IB4_Human1.43004094
43CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.42888712
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42745005
45HNFA_21074721_ChIP-Seq_CACO-2_Human1.42285285
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.40548583
47* ETV1_20927104_ChIP-Seq_GIST48_Human1.40027792
48NFYB_21822215_ChIP-Seq_K562_Human1.40017423
49RUNX2_22187159_ChIP-Seq_PCA_Human1.39738437
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39080864
51PHF8_20622853_ChIP-Seq_HELA_Human1.38779362
52* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.38230246
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36164266
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.36164266
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.35534596
56TBL1_22424771_ChIP-Seq_293T_Human1.35491382
57NANOG_20526341_ChIP-Seq_ESCs_Human1.35015184
58ERA_21632823_ChIP-Seq_H3396_Human1.32284393
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30846002
60TCF4_23295773_ChIP-Seq_U87_Human1.29898224
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28857361
62EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.28760957
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28076334
64WDR5_24793694_ChIP-Seq_LNCAP_Human1.27555473
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27179138
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27004382
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26953774
68RAC3_21632823_ChIP-Seq_H3396_Human1.26942215
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.26549786
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26060810
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.25749376
72TP53_18474530_ChIP-ChIP_U2OS_Human1.23911893
73* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.23319052
74ERG_20517297_ChIP-Seq_VCAP_Human1.22676901
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.21469159
76NFYA_21822215_ChIP-Seq_K562_Human1.21243508
77CDX2_22108803_ChIP-Seq_LS180_Human1.20799913
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20780312
79TP53_22573176_ChIP-Seq_HFKS_Human1.20465938
80TCF4_22108803_ChIP-Seq_LS180_Human1.19337458
81GATA6_21074721_ChIP-Seq_CACO-2_Human1.19071567
82* TAF2_19829295_ChIP-Seq_ESCs_Human1.16877965
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16006565
84GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.15686511
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.14699854
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14517977
87TDRD3_21172665_ChIP-Seq_MCF-7_Human1.13883934
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13094109
89SMAD3_21741376_ChIP-Seq_ESCs_Human1.11182408
90SALL4_22934838_ChIP-ChIP_CD34+_Human1.10836148
91NCOR_22424771_ChIP-Seq_293T_Human1.09372401
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.08538838
93OCT4_20526341_ChIP-Seq_ESCs_Human1.08417203
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.08270014
95TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.07833943
96EWS_26573619_Chip-Seq_HEK293_Human1.06471747
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06379499
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06349442
99CEBPB_22108803_ChIP-Seq_LS180_Human1.04979281
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04617824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.49044777
2MP0005377_hearing/vestibular/ear_phenot4.18296112
3MP0003878_abnormal_ear_physiology4.18296112
4MP0005670_abnormal_white_adipose4.09836433
5MP0003698_abnormal_male_reproductive3.67364809
6MP0008877_abnormal_DNA_methylation3.49013210
7MP0001929_abnormal_gametogenesis3.46215883
8MP0006292_abnormal_olfactory_placode2.49226825
9MP0003718_maternal_effect2.30622244
10MP0005379_endocrine/exocrine_gland_phen2.28622053
11MP0003646_muscle_fatigue2.16678373
12MP0001486_abnormal_startle_reflex2.12759847
13MP0001485_abnormal_pinna_reflex2.00110196
14MP0005645_abnormal_hypothalamus_physiol1.95768402
15MP0002161_abnormal_fertility/fecundity1.93802123
16MP0005551_abnormal_eye_electrophysiolog1.91218690
17MP0002210_abnormal_sex_determination1.87556753
18MP0003011_delayed_dark_adaptation1.62593102
19MP0004742_abnormal_vestibular_system1.61590391
20MP0005253_abnormal_eye_physiology1.59976664
21MP0008789_abnormal_olfactory_epithelium1.53424462
22MP0001145_abnormal_male_reproductive1.52960516
23MP0000653_abnormal_sex_gland1.49190179
24MP0003787_abnormal_imprinting1.43237264
25MP0002638_abnormal_pupillary_reflex1.39156419
26MP0005310_abnormal_salivary_gland1.39130761
27MP0001348_abnormal_lacrimal_gland1.36191743
28MP0002102_abnormal_ear_morphology1.35733886
29MP0003879_abnormal_hair_cell1.32763570
30MP0002735_abnormal_chemical_nociception1.24459781
31MP0002837_dystrophic_cardiac_calcinosis1.23840480
32MP0005394_taste/olfaction_phenotype1.21036132
33MP0005499_abnormal_olfactory_system1.21036132
34MP0002138_abnormal_hepatobiliary_system1.19403946
35MP0001984_abnormal_olfaction1.18138404
36MP0001968_abnormal_touch/_nociception1.16479445
37MP0001963_abnormal_hearing_physiology1.15701462
38MP0000516_abnormal_urinary_system1.15063398
39MP0005367_renal/urinary_system_phenotyp1.15063398
40MP0001986_abnormal_taste_sensitivity1.12069379
41MP0005084_abnormal_gallbladder_morpholo1.10137848
42MP0006072_abnormal_retinal_apoptosis1.06823879
43MP0009046_muscle_twitch1.05979479
44MP0002282_abnormal_trachea_morphology1.04030261
45MP0002938_white_spotting1.03882979
46MP0009697_abnormal_copulation0.99226253
47MP0001765_abnormal_ion_homeostasis0.98321924
48MP0002557_abnormal_social/conspecific_i0.98237779
49MP0002229_neurodegeneration0.97712285
50MP0005423_abnormal_somatic_nervous0.93994067
51MP0005636_abnormal_mineral_homeostasis0.92698560
52MP0009745_abnormal_behavioral_response0.92155965
53MP0002272_abnormal_nervous_system0.90032203
54MP0003195_calcinosis0.87154830
55MP0001905_abnormal_dopamine_level0.86715212
56MP0002234_abnormal_pharynx_morphology0.86172536
57MP0005395_other_phenotype0.85862068
58MP0002254_reproductive_system_inflammat0.83797902
59MP0008995_early_reproductive_senescence0.83007245
60MP0003880_abnormal_central_pattern0.82675250
61MP0000230_abnormal_systemic_arterial0.82266813
62MP0002876_abnormal_thyroid_physiology0.81841611
63MP0006276_abnormal_autonomic_nervous0.81711459
64MP0001666_abnormal_nutrient_absorption0.81488513
65MP0002067_abnormal_sensory_capabilities0.81421626
66MP0008872_abnormal_physiological_respon0.81246215
67MP0002572_abnormal_emotion/affect_behav0.80569833
68MP0000026_abnormal_inner_ear0.79715279
69MP0001501_abnormal_sleep_pattern0.79389404
70MP0001944_abnormal_pancreas_morphology0.78988810
71MP0002693_abnormal_pancreas_physiology0.78859835
72MP0010329_abnormal_lipoprotein_level0.77745813
73MP0009115_abnormal_fat_cell0.75640109
74MP0005391_vision/eye_phenotype0.73164120
75MP0005167_abnormal_blood-brain_barrier0.72270826
76MP0002127_abnormal_cardiovascular_syste0.71466278
77MP0010386_abnormal_urinary_bladder0.70699484
78MP0002160_abnormal_reproductive_system0.69719582
79MP0008058_abnormal_DNA_repair0.68191203
80MP0009764_decreased_sensitivity_to0.68097094
81MP0001873_stomach_inflammation0.66642808
82MP0000678_abnormal_parathyroid_gland0.63692236
83MP0004085_abnormal_heartbeat0.62917448
84MP0005332_abnormal_amino_acid0.62236150
85MP0003137_abnormal_impulse_conducting0.62235339
86MP0005389_reproductive_system_phenotype0.61594751
87MP0002163_abnormal_gland_morphology0.59337698
88MP0001970_abnormal_pain_threshold0.59285458
89MP0008057_abnormal_DNA_replication0.59281060
90MP0002733_abnormal_thermal_nociception0.58841936
91MP0001756_abnormal_urination0.57427000
92MP0002132_abnormal_respiratory_system0.57060829
93MP0002928_abnormal_bile_duct0.55901233
94MP0000955_abnormal_spinal_cord0.55373891
95MP0001529_abnormal_vocalization0.54116920
96MP0000631_abnormal_neuroendocrine_gland0.51228142
97MP0005257_abnormal_intraocular_pressure0.51142782
98MP0005666_abnormal_adipose_tissue0.48691479
99MP0001119_abnormal_female_reproductive0.48126103
100MP0002734_abnormal_mechanical_nocicepti0.47970584

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)6.32754996
2Tubulointerstitial nephritis (HP:0001970)6.01876707
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.60922349
4Absent/shortened dynein arms (HP:0200106)5.60922349
5Severe visual impairment (HP:0001141)4.76753984
6Abnormal ciliary motility (HP:0012262)4.46649506
7Abnormal respiratory motile cilium physiology (HP:0012261)4.21216357
8Attenuation of retinal blood vessels (HP:0007843)4.17891825
9Abnormal respiratory epithelium morphology (HP:0012253)4.10289664
10Abnormal respiratory motile cilium morphology (HP:0005938)4.10289664
11Abnormality of macular pigmentation (HP:0008002)3.95110360
12Hyperkalemia (HP:0002153)3.84425391
13Nephronophthisis (HP:0000090)3.84012449
14Bony spicule pigmentary retinopathy (HP:0007737)3.70037768
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.62015164
16Male infertility (HP:0003251)3.43842734
17Abnormality of the renal medulla (HP:0100957)3.33239418
18Hypoalphalipoproteinemia (HP:0003233)3.27652999
19Asymmetric septal hypertrophy (HP:0001670)3.25220979
20Abnormality of dental color (HP:0011073)3.24068245
21Progressive cerebellar ataxia (HP:0002073)3.22858482
22Menstrual irregularities (HP:0000858)3.18346662
23Cone-rod dystrophy (HP:0000548)3.16727466
24Insulin-resistant diabetes mellitus (HP:0000831)3.13971864
25Pancreatic cysts (HP:0001737)3.09868337
26Amelogenesis imperfecta (HP:0000705)3.05805740
27Hypoplasia of the thymus (HP:0000778)3.05243911
28Infertility (HP:0000789)3.01620343
29Hypoalbuminemia (HP:0003073)2.95465242
30Abnormal albumin level (HP:0012116)2.95465242
31Tubulointerstitial abnormality (HP:0001969)2.93184467
32Stage 5 chronic kidney disease (HP:0003774)2.82812708
33Resting tremor (HP:0002322)2.82468478
34Abnormal rod and cone electroretinograms (HP:0008323)2.79265639
35Pancreatic fibrosis (HP:0100732)2.79098523
36Intestinal atresia (HP:0011100)2.72599330
37Nasal polyposis (HP:0100582)2.72349729
38Abnormality of the renal cortex (HP:0011035)2.69987921
39Impulsivity (HP:0100710)2.68526219
40Rhinitis (HP:0012384)2.66693827
41Optic nerve hypoplasia (HP:0000609)2.59667143
42True hermaphroditism (HP:0010459)2.59203043
43Portal hypertension (HP:0001409)2.58375404
44Aplasia/Hypoplasia of the fovea (HP:0008060)2.56621815
45Hypoplasia of the fovea (HP:0007750)2.56621815
46Truncal obesity (HP:0001956)2.51764674
47Generalized aminoaciduria (HP:0002909)2.49855571
48Aplasia/Hypoplasia of the earlobes (HP:0009906)2.46364320
49Molar tooth sign on MRI (HP:0002419)2.44869697
50Abnormality of midbrain morphology (HP:0002418)2.44869697
51Polydipsia (HP:0001959)2.39707319
52Abnormal drinking behavior (HP:0030082)2.39707319
53Progressive sensorineural hearing impairment (HP:0000408)2.37809793
54Potter facies (HP:0002009)2.36320722
55Facial shape deformation (HP:0011334)2.36320722
56Tubular atrophy (HP:0000092)2.36250180
57Abnormality of the hepatic vasculature (HP:0006707)2.34309200
58Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.32338661
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32053013
60Congenital sensorineural hearing impairment (HP:0008527)2.31587968
61Abnormal spermatogenesis (HP:0008669)2.22280672
62Abnormality of the fovea (HP:0000493)2.16858174
63Pendular nystagmus (HP:0012043)2.14817170
64Abnormal urine output (HP:0012590)2.14681384
65Hypoglycemic seizures (HP:0002173)2.14541371
66Chronic bronchitis (HP:0004469)2.12568017
67Cystic liver disease (HP:0006706)2.10387177
68Abnormality of urine glucose concentration (HP:0011016)2.09872607
69Glycosuria (HP:0003076)2.09872607
70Congenital hepatic fibrosis (HP:0002612)2.07428452
71Abnormality of the nasal mucosa (HP:0000433)2.05024921
72Abnormality of the aortic arch (HP:0012303)2.04745142
73Renal Fanconi syndrome (HP:0001994)2.00699449
74Hypoproteinemia (HP:0003075)2.00500653
75Abnormality of potassium homeostasis (HP:0011042)1.99345794
76Hypoplastic ischia (HP:0003175)1.96521975
77Polyuria (HP:0000103)1.96410714
78Bronchiectasis (HP:0002110)1.95360831
79Decreased central vision (HP:0007663)1.95027420
80Pancreatic islet-cell hyperplasia (HP:0004510)1.91987217
81Hyperuricemia (HP:0002149)1.91959286
82Increased purine levels (HP:0004368)1.91959286
83Genetic anticipation (HP:0003743)1.90852234
84Abnormality of renal excretion (HP:0011036)1.89897272
85Azoospermia (HP:0000027)1.89313024
86Gastrointestinal atresia (HP:0002589)1.87189157
87Hypolipoproteinemia (HP:0010981)1.86353086
88Occipital encephalocele (HP:0002085)1.84809378
89Bell-shaped thorax (HP:0001591)1.84298727
90Intellectual disability, moderate (HP:0002342)1.80065917
91Enlarged epiphyses (HP:0010580)1.78513367
92Growth hormone deficiency (HP:0000824)1.76101618
93Medial flaring of the eyebrow (HP:0010747)1.74672095
94Postural instability (HP:0002172)1.73853470
95Congenital malformation of the right heart (HP:0011723)1.72268886
96Double outlet right ventricle (HP:0001719)1.72268886
97Abnormality of the costochondral junction (HP:0000919)1.70947792
98Abnormality of the ischium (HP:0003174)1.70572226
99Photophobia (HP:0000613)1.70091685
100Abolished electroretinogram (ERG) (HP:0000550)1.69844157

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.80870714
2INSRR5.61321964
3FRK3.65421904
4PNCK3.65289628
5BRD43.62341722
6MAP4K23.40919112
7PLK23.36159206
8PIK3CG2.52290518
9STK38L2.11642017
10PTK2B2.06705381
11TESK11.90678904
12CAMK1G1.73993666
13BMPR1B1.58601609
14STK381.45786966
15TYRO31.42119142
16WNK41.40348034
17ACVR1B1.36747712
18TRIM281.35947056
19WNK11.35894421
20NEK61.29632349
21PINK11.26119899
22DDR21.17308151
23TXK1.16789003
24MAPK131.14933573
25WNK31.13120942
26ADRBK21.10279496
27PDK11.09039675
28TIE11.05765665
29PRKD30.94664093
30GRK10.94168208
31ZAK0.86136548
32MST1R0.85467920
33MAPK150.83642259
34OXSR10.83140847
35AKT30.79039131
36PDPK10.78805972
37MAP3K40.77734816
38CDK30.76877688
39BRSK20.73956190
40MST40.71219723
41CSNK1G20.70938437
42CSNK1G10.69765437
43PRKCG0.69340860
44NTRK30.66214898
45STK390.64168062
46EIF2AK30.61624680
47CSNK1G30.61401772
48MARK10.60475252
49NUAK10.58249259
50FGFR20.54259886
51MAP2K70.54052760
52CDK190.54038185
53VRK10.53268103
54PRKG10.53015783
55PRKCE0.51604959
56TAOK30.51002878
57ERBB30.49056285
58TNIK0.48653098
59CDK70.47823934
60MKNK20.45414586
61TLK10.45125384
62CSNK1A1L0.44751129
63MAP3K20.43479557
64CAMK10.41389009
65DAPK20.40406875
66MUSK0.40091720
67CSNK1A10.36326871
68TAF10.35719556
69FER0.35126422
70ITK0.34802920
71BMPR20.34487971
72DYRK30.32532162
73TEC0.31162409
74PRKCB0.30104407
75MAP2K60.29983449
76PLK30.29568922
77MAPK10.28656722
78CSNK1D0.28539033
79GSK3B0.28004649
80SGK10.27780783
81PRKACA0.27311905
82* CDK10.27129667
83CAMK2A0.25608888
84WEE10.25141063
85MAP3K120.25131275
86PRKG20.24612465
87ROCK10.24506567
88ATM0.22472794
89MINK10.21854941
90DYRK20.21776993
91CDK20.21574099
92NME10.21470230
93PRKAA20.21186168
94SRPK10.21013795
95PLK10.20917381
96PRKCQ0.20061430
97MET0.19748052
98PHKG10.19545533
99PHKG20.19545533
100PRKACB0.19510857

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.49928655
2Fatty acid biosynthesis_Homo sapiens_hsa000614.57231044
3Olfactory transduction_Homo sapiens_hsa047403.37313795
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.13405024
5Butanoate metabolism_Homo sapiens_hsa006502.96987501
6Phototransduction_Homo sapiens_hsa047442.35006394
7Type I diabetes mellitus_Homo sapiens_hsa049402.32797644
8* RNA transport_Homo sapiens_hsa030132.05680510
9Autoimmune thyroid disease_Homo sapiens_hsa053201.91543511
10Asthma_Homo sapiens_hsa053101.85861619
11Taste transduction_Homo sapiens_hsa047421.73953367
12Allograft rejection_Homo sapiens_hsa053301.69525967
13Graft-versus-host disease_Homo sapiens_hsa053321.65496199
14Fanconi anemia pathway_Homo sapiens_hsa034601.59660290
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.56277805
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54126519
17Dorso-ventral axis formation_Homo sapiens_hsa043201.49907264
18Basal transcription factors_Homo sapiens_hsa030221.49530238
19Fatty acid degradation_Homo sapiens_hsa000711.43470964
20Nicotine addiction_Homo sapiens_hsa050331.37443677
21Nitrogen metabolism_Homo sapiens_hsa009101.36955780
22Antigen processing and presentation_Homo sapiens_hsa046121.34647180
23Propanoate metabolism_Homo sapiens_hsa006401.29216324
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.28611076
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25079892
26Linoleic acid metabolism_Homo sapiens_hsa005911.25044726
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18900780
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17780278
29ABC transporters_Homo sapiens_hsa020101.17540308
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16769620
31Huntingtons disease_Homo sapiens_hsa050161.15520203
32Fatty acid metabolism_Homo sapiens_hsa012121.13190419
33Regulation of autophagy_Homo sapiens_hsa041401.10879941
34Oocyte meiosis_Homo sapiens_hsa041141.09569812
35Oxidative phosphorylation_Homo sapiens_hsa001901.04434583
36Cardiac muscle contraction_Homo sapiens_hsa042601.02392551
37Selenocompound metabolism_Homo sapiens_hsa004501.02352898
38Serotonergic synapse_Homo sapiens_hsa047261.00584552
39Tryptophan metabolism_Homo sapiens_hsa003801.00429291
40Vitamin B6 metabolism_Homo sapiens_hsa007500.97873513
41Type II diabetes mellitus_Homo sapiens_hsa049300.96720540
42Retinol metabolism_Homo sapiens_hsa008300.93858276
43Fat digestion and absorption_Homo sapiens_hsa049750.93738689
44Morphine addiction_Homo sapiens_hsa050320.93661271
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93293250
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.90966245
47Salivary secretion_Homo sapiens_hsa049700.86471368
48Circadian entrainment_Homo sapiens_hsa047130.86360505
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82706831
50Arginine and proline metabolism_Homo sapiens_hsa003300.81067819
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80384375
52Insulin secretion_Homo sapiens_hsa049110.79324152
53Protein export_Homo sapiens_hsa030600.79097650
54Glycerolipid metabolism_Homo sapiens_hsa005610.76405382
55Chemical carcinogenesis_Homo sapiens_hsa052040.76078369
56Glutamatergic synapse_Homo sapiens_hsa047240.74940168
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74494853
58Calcium signaling pathway_Homo sapiens_hsa040200.73891996
59RNA degradation_Homo sapiens_hsa030180.72108475
60Circadian rhythm_Homo sapiens_hsa047100.70891310
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.69256383
62GABAergic synapse_Homo sapiens_hsa047270.67971008
63Homologous recombination_Homo sapiens_hsa034400.63731510
64Arginine biosynthesis_Homo sapiens_hsa002200.62201433
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61925834
66Purine metabolism_Homo sapiens_hsa002300.58343344
67Parkinsons disease_Homo sapiens_hsa050120.57571576
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57269270
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56648924
70Peroxisome_Homo sapiens_hsa041460.54967433
71Metabolic pathways_Homo sapiens_hsa011000.53486129
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51919240
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51717899
74Renin secretion_Homo sapiens_hsa049240.51651928
75Renin-angiotensin system_Homo sapiens_hsa046140.51237494
76Phenylalanine metabolism_Homo sapiens_hsa003600.50683982
77Caffeine metabolism_Homo sapiens_hsa002320.50345364
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50147881
79Viral myocarditis_Homo sapiens_hsa054160.49292899
80Rheumatoid arthritis_Homo sapiens_hsa053230.48666928
81Amphetamine addiction_Homo sapiens_hsa050310.45992247
82cAMP signaling pathway_Homo sapiens_hsa040240.45825431
83Inositol phosphate metabolism_Homo sapiens_hsa005620.41795857
84beta-Alanine metabolism_Homo sapiens_hsa004100.41780269
85Alzheimers disease_Homo sapiens_hsa050100.41130174
86Ether lipid metabolism_Homo sapiens_hsa005650.40786613
87Synaptic vesicle cycle_Homo sapiens_hsa047210.40645542
88mRNA surveillance pathway_Homo sapiens_hsa030150.40184894
89RNA polymerase_Homo sapiens_hsa030200.40159841
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39849308
91Non-homologous end-joining_Homo sapiens_hsa034500.37486134
92Hedgehog signaling pathway_Homo sapiens_hsa043400.37171298
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36418467
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35248581
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34646732
96Pancreatic secretion_Homo sapiens_hsa049720.34421881
97Protein digestion and absorption_Homo sapiens_hsa049740.34371631
98PPAR signaling pathway_Homo sapiens_hsa033200.33946097
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32091774
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31991089

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