RGPD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)6.75189338
2* protein targeting to Golgi (GO:0000042)6.61522639
3* establishment of protein localization to Golgi (GO:0072600)6.56337738
4sperm motility (GO:0030317)6.41852048
5* retrograde transport, vesicle recycling within Golgi (GO:0000301)5.85049077
6fusion of sperm to egg plasma membrane (GO:0007342)5.38046497
7* protein localization to Golgi apparatus (GO:0034067)5.26675482
8multicellular organism reproduction (GO:0032504)5.22489012
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.22141689
10arginine catabolic process (GO:0006527)4.91454332
11axonemal dynein complex assembly (GO:0070286)4.64270465
12microtubule depolymerization (GO:0007019)4.59358812
13response to pheromone (GO:0019236)4.52893313
14epithelial cilium movement (GO:0003351)4.52827424
15cellular ketone body metabolic process (GO:0046950)4.44974071
16spermatid development (GO:0007286)4.36474670
17regulation of cilium movement (GO:0003352)4.32300170
18arginine metabolic process (GO:0006525)4.30120501
19protein polyglutamylation (GO:0018095)4.22161826
20phosphatidylethanolamine biosynthetic process (GO:0006646)4.18906843
21single strand break repair (GO:0000012)4.18406807
22reproduction (GO:0000003)4.15036759
23phosphatidylethanolamine metabolic process (GO:0046337)4.10471988
24sperm capacitation (GO:0048240)4.10093706
25plasma membrane fusion (GO:0045026)4.06782398
26negative regulation of neurotransmitter transport (GO:0051589)4.05114267
27cilium or flagellum-dependent cell motility (GO:0001539)4.05109663
28microtubule polymerization or depolymerization (GO:0031109)4.01220397
29negative regulation of calcium ion transport into cytosol (GO:0010523)4.01204648
30sperm-egg recognition (GO:0035036)3.99412581
31centriole replication (GO:0007099)3.98288806
32calcium ion-dependent exocytosis (GO:0017156)3.94437434
33ketone body metabolic process (GO:1902224)3.92427979
34cilium movement (GO:0003341)3.88240269
35negative regulation of amino acid transport (GO:0051956)3.80682234
36male meiosis I (GO:0007141)3.71987456
37RNA destabilization (GO:0050779)3.71816986
38serotonin receptor signaling pathway (GO:0007210)3.64257066
39positive regulation of guanylate cyclase activity (GO:0031284)3.61572089
40spermatogenesis (GO:0007283)3.56017563
41male gamete generation (GO:0048232)3.55844472
42piRNA metabolic process (GO:0034587)3.53651618
43regulation of neurotransmitter uptake (GO:0051580)3.52463738
44indole-containing compound catabolic process (GO:0042436)3.51642823
45indolalkylamine catabolic process (GO:0046218)3.51642823
46tryptophan catabolic process (GO:0006569)3.51642823
47seminiferous tubule development (GO:0072520)3.51354455
48single fertilization (GO:0007338)3.46342904
49pyrimidine ribonucleoside catabolic process (GO:0046133)3.37843523
50gamete generation (GO:0007276)3.35447106
51male meiosis (GO:0007140)3.35109978
52regulation of glutamate secretion (GO:0014048)3.34869635
53regulation of guanylate cyclase activity (GO:0031282)3.34671290
54cell-cell recognition (GO:0009988)3.26629759
55centriole assembly (GO:0098534)3.23775003
56indolalkylamine metabolic process (GO:0006586)3.20591012
57photoreceptor cell maintenance (GO:0045494)3.18121169
58nephron tubule morphogenesis (GO:0072078)3.17613970
59nephron epithelium morphogenesis (GO:0072088)3.17613970
60diaphragm development (GO:0060539)3.15245351
61regulation of acrosome reaction (GO:0060046)3.14210284
62positive regulation of catecholamine secretion (GO:0033605)3.11304502
63neural tube formation (GO:0001841)3.04335379
64positive regulation of Rab GTPase activity (GO:0032851)3.04017105
65regulation of Rab GTPase activity (GO:0032313)3.04017105
66exogenous drug catabolic process (GO:0042738)3.01948508
67positive regulation of amino acid transport (GO:0051957)3.01827521
68skeletal muscle organ development (GO:0060538)3.01132125
69meiosis I (GO:0007127)2.97718440
70spermatid nucleus differentiation (GO:0007289)2.96134506
71germ cell development (GO:0007281)2.95970425
72protein K11-linked deubiquitination (GO:0035871)2.93214890
73somite rostral/caudal axis specification (GO:0032525)2.89694250
74organic cation transport (GO:0015695)2.89243758
75detection of light stimulus involved in sensory perception (GO:0050962)2.87924301
76detection of light stimulus involved in visual perception (GO:0050908)2.87924301
77tryptophan metabolic process (GO:0006568)2.85528477
78protein localization to cilium (GO:0061512)2.84066853
79regulation of dopamine secretion (GO:0014059)2.83617425
80positive regulation of action potential (GO:0045760)2.83197695
81DNA packaging (GO:0006323)2.82559340
82cytidine metabolic process (GO:0046087)2.79464881
83cytidine catabolic process (GO:0006216)2.79464881
84cytidine deamination (GO:0009972)2.79464881
85cellular biogenic amine catabolic process (GO:0042402)2.79227257
86amine catabolic process (GO:0009310)2.79227257
87binding of sperm to zona pellucida (GO:0007339)2.78882234
88regulation of transcription involved in cell fate commitment (GO:0060850)2.78270763
89fertilization (GO:0009566)2.76442026
90* intra-Golgi vesicle-mediated transport (GO:0006891)2.75350994
91peptidyl-threonine dephosphorylation (GO:0035970)2.74080674
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73214831
93DNA methylation involved in gamete generation (GO:0043046)2.68245509
94negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.65729783
95membrane depolarization during action potential (GO:0086010)2.65110299
96spinal cord motor neuron differentiation (GO:0021522)2.64742441
97positive regulation of meiosis (GO:0045836)2.64674167
98regulation of meiosis I (GO:0060631)2.64596600
99multicellular organismal reproductive process (GO:0048609)2.63912380
100negative regulation of multicellular organism growth (GO:0040015)2.61867730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.94136203
2ZNF274_21170338_ChIP-Seq_K562_Hela2.80262993
3VDR_22108803_ChIP-Seq_LS180_Human2.74995955
4CTBP2_25329375_ChIP-Seq_LNCAP_Human2.61348244
5TAF15_26573619_Chip-Seq_HEK293_Human2.45698710
6GBX2_23144817_ChIP-Seq_PC3_Human2.40465189
7FUS_26573619_Chip-Seq_HEK293_Human2.24317855
8IGF1R_20145208_ChIP-Seq_DFB_Human2.13346987
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11009791
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05108992
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.00413266
12CBP_20019798_ChIP-Seq_JUKART_Human2.00413266
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98712673
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96418659
15UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.91695666
16P300_19829295_ChIP-Seq_ESCs_Human1.89107985
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87180555
18ER_23166858_ChIP-Seq_MCF-7_Human1.86615589
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84316528
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82933162
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75012892
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71590777
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.71096034
24SMAD3_21741376_ChIP-Seq_EPCs_Human1.69035991
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68822538
26AR_25329375_ChIP-Seq_VCAP_Human1.68454190
27SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.66581057
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63652090
29POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63527297
30TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63527297
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63094119
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58107348
33DROSHA_22980978_ChIP-Seq_HELA_Human1.57538648
34* SMAD4_21741376_ChIP-Seq_EPCs_Human1.57039504
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54475848
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53996987
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.53455379
38AR_21572438_ChIP-Seq_LNCaP_Human1.51987690
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51505615
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49391410
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.49171575
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.47319209
43VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.45744428
44TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.40370215
45STAT3_23295773_ChIP-Seq_U87_Human1.36636463
46RUNX2_22187159_ChIP-Seq_PCA_Human1.33722855
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.33633428
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33004747
49PRDM14_20953172_ChIP-Seq_ESCs_Human1.32321651
50* SMAD3_21741376_ChIP-Seq_ESCs_Human1.31025684
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30497222
52SOX2_19829295_ChIP-Seq_ESCs_Human1.28876875
53NANOG_19829295_ChIP-Seq_ESCs_Human1.28876875
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28828523
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.28395776
56REST_21632747_ChIP-Seq_MESCs_Mouse1.28238136
57BCAT_22108803_ChIP-Seq_LS180_Human1.26863445
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26541200
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.25652831
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23668777
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.23668777
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.22883446
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22206439
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22196573
65EWS_26573619_Chip-Seq_HEK293_Human1.21079262
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20606557
67TP53_22573176_ChIP-Seq_HFKS_Human1.20275733
68RNF2_27304074_Chip-Seq_NSC_Mouse1.20184219
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19462352
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18968435
71* ETV1_20927104_ChIP-Seq_GIST48_Human1.18960654
72TCF4_23295773_ChIP-Seq_U87_Human1.18949764
73JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18412723
74TCF4_22108803_ChIP-Seq_LS180_Human1.18096697
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17994189
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.16993571
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16167511
78TBL1_22424771_ChIP-Seq_293T_Human1.16072907
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.14540263
80NANOG_20526341_ChIP-Seq_ESCs_Human1.14427516
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13413754
82NCOR_22424771_ChIP-Seq_293T_Human1.13161459
83ERA_21632823_ChIP-Seq_H3396_Human1.12769855
84CDX2_22108803_ChIP-Seq_LS180_Human1.11801643
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.10805088
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10623300
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10503976
88TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.10351745
89OCT1_27270436_Chip-Seq_PROSTATE_Human1.10180150
90RBPJ_21746931_ChIP-Seq_IB4_Human1.10039158
91TAF2_19829295_ChIP-Seq_ESCs_Human1.09323841
92MYC_19829295_ChIP-Seq_ESCs_Human1.08680473
93KDM2B_26808549_Chip-Seq_REH_Human1.06579046
94CBX2_22325352_ChIP-Seq_293T-Rex_Human1.06570756
95NFYA_21822215_ChIP-Seq_K562_Human1.06001830
96NFYB_21822215_ChIP-Seq_K562_Human1.05792879
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05645415
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.05559550
99ERG_20517297_ChIP-Seq_VCAP_Human1.05319401
100TP53_18474530_ChIP-ChIP_U2OS_Human1.05278559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.95264721
2MP0002234_abnormal_pharynx_morphology3.56730744
3MP0003646_muscle_fatigue3.30413546
4MP0000566_synostosis3.10443321
5MP0003183_abnormal_peptide_metabolism2.98470553
6MP0003878_abnormal_ear_physiology2.81196610
7MP0005377_hearing/vestibular/ear_phenot2.81196610
8MP0003011_delayed_dark_adaptation2.75681912
9MP0005379_endocrine/exocrine_gland_phen2.70195571
10MP0005167_abnormal_blood-brain_barrier2.63100153
11MP0005645_abnormal_hypothalamus_physiol2.45415920
12MP0002163_abnormal_gland_morphology2.25519386
13MP0003698_abnormal_male_reproductive2.20412014
14MP0004043_abnormal_pH_regulation2.15859633
15MP0003283_abnormal_digestive_organ2.06216587
16MP0008877_abnormal_DNA_methylation2.05413318
17MP0004742_abnormal_vestibular_system2.03646039
18MP0001968_abnormal_touch/_nociception2.00385493
19MP0002928_abnormal_bile_duct1.97651401
20MP0009745_abnormal_behavioral_response1.91181362
21MP0001929_abnormal_gametogenesis1.82733394
22MP0000569_abnormal_digit_pigmentation1.75205244
23MP0005551_abnormal_eye_electrophysiolog1.73940399
24MP0002735_abnormal_chemical_nociception1.71891611
25MP0008872_abnormal_physiological_respon1.67874674
26MP0003718_maternal_effect1.62167347
27MP0002736_abnormal_nociception_after1.59421387
28MP0001919_abnormal_reproductive_system1.54687811
29MP0002837_dystrophic_cardiac_calcinosis1.48829651
30MP0003879_abnormal_hair_cell1.47946700
31MP0005389_reproductive_system_phenotype1.45943536
32MP0000631_abnormal_neuroendocrine_gland1.43980765
33MP0002102_abnormal_ear_morphology1.42005532
34MP0003880_abnormal_central_pattern1.41504070
35MP0002272_abnormal_nervous_system1.39698503
36MP0001485_abnormal_pinna_reflex1.39484134
37MP0002876_abnormal_thyroid_physiology1.37878605
38MP0001501_abnormal_sleep_pattern1.37630689
39MP0001486_abnormal_startle_reflex1.37248409
40MP0001905_abnormal_dopamine_level1.32360904
41MP0003252_abnormal_bile_duct1.30392594
42MP0005670_abnormal_white_adipose1.29313428
43MP0001970_abnormal_pain_threshold1.25521752
44MP0001440_abnormal_grooming_behavior1.24102698
45MP0002064_seizures1.23466033
46MP0008875_abnormal_xenobiotic_pharmacok1.22662067
47MP0003045_fibrosis1.21310610
48MP0002572_abnormal_emotion/affect_behav1.20366159
49MP0000026_abnormal_inner_ear1.19888001
50MP0001529_abnormal_vocalization1.16815145
51MP0002210_abnormal_sex_determination1.16194743
52MP0002161_abnormal_fertility/fecundity1.15921477
53MP0005253_abnormal_eye_physiology1.14365731
54MP0001984_abnormal_olfaction1.13087501
55MP0002067_abnormal_sensory_capabilities1.12385384
56MP0001765_abnormal_ion_homeostasis1.10043151
57MP0008961_abnormal_basal_metabolism1.09241456
58MP0002160_abnormal_reproductive_system1.08839803
59MP0005386_behavior/neurological_phenoty1.07137127
60MP0004924_abnormal_behavior1.07137127
61MP0001963_abnormal_hearing_physiology1.06949211
62MP0001664_abnormal_digestion1.06111857
63MP0000653_abnormal_sex_gland1.06075449
64MP0005423_abnormal_somatic_nervous1.05556940
65MP0002277_abnormal_respiratory_mucosa1.03527411
66MP0005084_abnormal_gallbladder_morpholo1.03033031
67MP0002557_abnormal_social/conspecific_i1.00255107
68MP0004142_abnormal_muscle_tone0.99466514
69MP0006276_abnormal_autonomic_nervous0.96596954
70MP0002127_abnormal_cardiovascular_syste0.95009724
71MP0009046_muscle_twitch0.93636071
72MP0001145_abnormal_male_reproductive0.93549106
73MP0002733_abnormal_thermal_nociception0.92044077
74MP0010386_abnormal_urinary_bladder0.91201455
75MP0002063_abnormal_learning/memory/cond0.90135629
76MP0001986_abnormal_taste_sensitivity0.89811766
77MP0003787_abnormal_imprinting0.87101562
78MP0000230_abnormal_systemic_arterial0.85676371
79MP0003635_abnormal_synaptic_transmissio0.85465479
80MP0000955_abnormal_spinal_cord0.84961291
81MP0001879_abnormal_lymphatic_vessel0.84147199
82MP0002138_abnormal_hepatobiliary_system0.80256903
83MP0000049_abnormal_middle_ear0.78180307
84MP0009780_abnormal_chondrocyte_physiolo0.77481995
85MP0002229_neurodegeneration0.76538206
86MP0009053_abnormal_anal_canal0.76016722
87MP0006292_abnormal_olfactory_placode0.74845512
88MP0003959_abnormal_lean_body0.74820304
89MP0004084_abnormal_cardiac_muscle0.74285388
90MP0000470_abnormal_stomach_morphology0.74229082
91MP0002734_abnormal_mechanical_nocicepti0.73927857
92MP0004885_abnormal_endolymph0.73609475
93MP0000372_irregular_coat_pigmentation0.71870105
94MP0005636_abnormal_mineral_homeostasis0.71844833
95MP0004484_altered_response_of0.71027448
96MP0001756_abnormal_urination0.69837292
97MP0002752_abnormal_somatic_nervous0.68514862
98MP0006082_CNS_inflammation0.68369271
99MP0003195_calcinosis0.68219493
100MP0002184_abnormal_innervation0.67730099

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.62602725
2Absent/shortened dynein arms (HP:0200106)4.71571652
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.71571652
4Abnormal respiratory epithelium morphology (HP:0012253)4.13513336
5Abnormal respiratory motile cilium morphology (HP:0005938)4.13513336
6Progressive cerebellar ataxia (HP:0002073)4.03277852
7Tubular atrophy (HP:0000092)3.92364660
8Attenuation of retinal blood vessels (HP:0007843)3.78199706
9Pancreatic cysts (HP:0001737)3.78157425
10Abnormal rod and cone electroretinograms (HP:0008323)3.61679376
11Abnormal respiratory motile cilium physiology (HP:0012261)3.60978682
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.53205533
13Abnormal ciliary motility (HP:0012262)3.44335847
14Bony spicule pigmentary retinopathy (HP:0007737)3.38449434
15Hypoproteinemia (HP:0003075)3.36183314
16Nephronophthisis (HP:0000090)3.27188451
17Abnormality of the renal cortex (HP:0011035)3.25651977
18Hypoplasia of the thymus (HP:0000778)3.14050763
19Genetic anticipation (HP:0003743)3.13937356
20Potter facies (HP:0002009)3.11398352
21Facial shape deformation (HP:0011334)3.11398352
22Abnormality of the renal medulla (HP:0100957)3.09618690
23Generalized aminoaciduria (HP:0002909)3.03877126
24Polydipsia (HP:0001959)2.98163628
25Abnormal drinking behavior (HP:0030082)2.98163628
26Type II lissencephaly (HP:0007260)2.97919133
27Chronic hepatic failure (HP:0100626)2.97185061
28Abnormality of macular pigmentation (HP:0008002)2.87426887
29Pancreatic fibrosis (HP:0100732)2.84682950
30Autoimmune thrombocytopenia (HP:0001973)2.83787309
31Tubulointerstitial abnormality (HP:0001969)2.81122248
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.79532822
33Focal motor seizures (HP:0011153)2.79164906
34Congenital sensorineural hearing impairment (HP:0008527)2.76887737
35Tubulointerstitial fibrosis (HP:0005576)2.75773140
36Pendular nystagmus (HP:0012043)2.72861451
37Tubulointerstitial nephritis (HP:0001970)2.58080718
38Ureteral stenosis (HP:0000071)2.48632174
39Keratoconus (HP:0000563)2.46465869
40Increased corneal curvature (HP:0100692)2.46465869
41Ureteral obstruction (HP:0006000)2.44121391
42Dialeptic seizures (HP:0011146)2.43730139
43Congenital stationary night blindness (HP:0007642)2.42268940
44Rhinitis (HP:0012384)2.38753166
45Absence seizures (HP:0002121)2.37446160
46Atonic seizures (HP:0010819)2.37317993
47Thyroiditis (HP:0100646)2.37285495
48Polyuria (HP:0000103)2.28827691
49Cerebellar dysplasia (HP:0007033)2.22235694
50Infertility (HP:0000789)2.20357263
51Abnormal urine output (HP:0012590)2.20227783
52True hermaphroditism (HP:0010459)2.18416653
53Decreased central vision (HP:0007663)2.16342946
54Cystic liver disease (HP:0006706)2.15718284
55Concave nail (HP:0001598)2.15386274
56Chronic bronchitis (HP:0004469)2.14683986
57Focal seizures (HP:0007359)2.07645367
58Bronchiectasis (HP:0002110)2.03257762
59Abnormality of renal excretion (HP:0011036)2.00099953
60Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.99533985
61Lip pit (HP:0100267)1.95695694
62Popliteal pterygium (HP:0009756)1.94121311
63Male infertility (HP:0003251)1.92654277
64B lymphocytopenia (HP:0010976)1.92395161
65Renal Fanconi syndrome (HP:0001994)1.92005885
66Bile duct proliferation (HP:0001408)1.91983332
67Abnormal biliary tract physiology (HP:0012439)1.91983332
68Postural instability (HP:0002172)1.90425243
69Severe combined immunodeficiency (HP:0004430)1.89506696
70Anal stenosis (HP:0002025)1.89320881
71Bilateral microphthalmos (HP:0007633)1.88680031
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85070925
73Abnormality of B cell number (HP:0010975)1.84889192
74Hypoplastic ischia (HP:0003175)1.84515211
75Ectopic kidney (HP:0000086)1.83475244
76Hyperkalemia (HP:0002153)1.82920441
77Supernumerary spleens (HP:0009799)1.81926997
78Glycosuria (HP:0003076)1.80368884
79Abnormality of urine glucose concentration (HP:0011016)1.80368884
80Abnormality of dental color (HP:0011073)1.78701104
81Febrile seizures (HP:0002373)1.78571577
82Medial flaring of the eyebrow (HP:0010747)1.77963558
83Amelogenesis imperfecta (HP:0000705)1.77963332
84Optic nerve hypoplasia (HP:0000609)1.77139279
85Thoracolumbar scoliosis (HP:0002944)1.76142445
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75890239
87Retinal dysplasia (HP:0007973)1.75292655
88Carpal bone hypoplasia (HP:0001498)1.73689767
893-Methylglutaconic aciduria (HP:0003535)1.71370207
90Panhypogammaglobulinemia (HP:0003139)1.71287403
91Lissencephaly (HP:0001339)1.70936364
92Absent thumb (HP:0009777)1.70499197
93Congenital hepatic fibrosis (HP:0002612)1.70201281
94Hypoplasia of the fovea (HP:0007750)1.70127570
95Aplasia/Hypoplasia of the fovea (HP:0008060)1.70127570
96Broad ribs (HP:0000885)1.70049232
97Action tremor (HP:0002345)1.69535271
98Stage 5 chronic kidney disease (HP:0003774)1.67853456
99Short 5th finger (HP:0009237)1.67659856
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67386433

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.20627837
2MAP4K23.81595285
3PLK43.35015073
4PINK13.26490607
5FRK3.22245701
6INSRR2.99286586
7TXK2.65026158
8STK242.64518030
9BMPR1B2.59801042
10BCKDK2.55448960
11STK392.40228151
12ZAK2.21352495
13PNCK2.17362388
14MAPK152.16612982
15MAP3K21.99929723
16PLK21.92900466
17TNIK1.89123631
18MAPK131.66317186
19ADRBK21.64577325
20WNK31.55065995
21WNK11.53895188
22MAP3K41.46976393
23CDK191.42063112
24GRK11.36660605
25ACVR1B1.29892916
26CAMKK21.20222877
27CCNB11.19677236
28PIK3CA1.17183412
29MAP2K71.15788282
30CAMK41.15494893
31CAMK11.12588892
32MARK11.07827061
33OXSR11.07476908
34PIK3CG1.04228361
35MAP3K61.03688750
36NTRK20.98707027
37DDR20.98220910
38STK38L0.95963728
39MAPKAPK30.95787604
40MAP3K30.93782647
41CASK0.92220380
42MAP2K40.91646248
43PRKCG0.91019791
44DYRK30.90266149
45CAMK1G0.81301080
46MINK10.80172226
47PRKCQ0.79427195
48RPS6KA60.78598425
49LATS10.77072588
50PASK0.76748955
51ADRBK10.76656491
52DAPK20.72893130
53STK380.72825973
54NTRK30.68902574
55JAK30.64784139
56NUAK10.64369830
57PTK2B0.64167689
58RPS6KC10.61555154
59RPS6KL10.61555154
60MST40.60424380
61SGK10.60205595
62SGK2230.60199349
63SGK4940.60199349
64TGFBR10.59043471
65GRK70.58931764
66NLK0.58269937
67BRD40.56606346
68PRKG10.55773988
69MAP2K60.55248478
70FGFR20.54290580
71DYRK20.51771897
72VRK10.48791402
73LMTK20.47151892
74GRK50.47150893
75TYRO30.46011621
76CHEK20.45206356
77MAPKAPK50.43338335
78MST1R0.42690792
79PRKCE0.40136520
80IRAK20.40136479
81TRPM70.40114447
82PRKACA0.39630722
83RPS6KA20.34743245
84CAMK2A0.34327013
85SGK20.33892184
86PDK10.33785887
87SYK0.33138615
88UHMK10.33014823
89EIF2AK30.32943647
90PRKCH0.32691484
91KIT0.30197670
92DYRK1A0.29613165
93RPS6KA40.29324151
94MAP3K50.28940153
95PRKCA0.28069356
96CHUK0.27337241
97ITK0.27284982
98PRKAA20.26783415
99OBSCN0.26386283
100PHKG20.26211735

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.26481042
2Phototransduction_Homo sapiens_hsa047442.95052295
3Taste transduction_Homo sapiens_hsa047422.49420494
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.45623689
5Olfactory transduction_Homo sapiens_hsa047402.40941317
6Butanoate metabolism_Homo sapiens_hsa006502.26012785
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.06413624
8Nicotine addiction_Homo sapiens_hsa050332.01511419
9Oxidative phosphorylation_Homo sapiens_hsa001901.99386531
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.89740819
11Fatty acid biosynthesis_Homo sapiens_hsa000611.82276763
12Circadian entrainment_Homo sapiens_hsa047131.81455502
13Linoleic acid metabolism_Homo sapiens_hsa005911.80464236
14Morphine addiction_Homo sapiens_hsa050321.78614893
15Cardiac muscle contraction_Homo sapiens_hsa042601.77454258
16Serotonergic synapse_Homo sapiens_hsa047261.73080943
17Salivary secretion_Homo sapiens_hsa049701.72748954
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67388436
19Glutamatergic synapse_Homo sapiens_hsa047241.61635344
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.58458236
21GABAergic synapse_Homo sapiens_hsa047271.55704882
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50397789
23Autoimmune thyroid disease_Homo sapiens_hsa053201.46784938
24Parkinsons disease_Homo sapiens_hsa050121.42338965
25Nitrogen metabolism_Homo sapiens_hsa009101.41907329
26Graft-versus-host disease_Homo sapiens_hsa053321.41157624
27Arginine biosynthesis_Homo sapiens_hsa002201.40792200
28Type I diabetes mellitus_Homo sapiens_hsa049401.35491707
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32967175
30Alzheimers disease_Homo sapiens_hsa050101.32272195
31Caffeine metabolism_Homo sapiens_hsa002321.25958977
32ABC transporters_Homo sapiens_hsa020101.21790583
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21303686
34Allograft rejection_Homo sapiens_hsa053301.19610186
35Tryptophan metabolism_Homo sapiens_hsa003801.19347078
36Calcium signaling pathway_Homo sapiens_hsa040201.19183244
37Huntingtons disease_Homo sapiens_hsa050161.16012055
38Dorso-ventral axis formation_Homo sapiens_hsa043201.14706962
39Renin secretion_Homo sapiens_hsa049241.12728440
40Dopaminergic synapse_Homo sapiens_hsa047281.11434717
41Ether lipid metabolism_Homo sapiens_hsa005651.09819202
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06390213
43Retinol metabolism_Homo sapiens_hsa008300.99908191
44Insulin secretion_Homo sapiens_hsa049110.98710216
45Cholinergic synapse_Homo sapiens_hsa047250.98125356
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96441690
47Collecting duct acid secretion_Homo sapiens_hsa049660.95265285
48Primary immunodeficiency_Homo sapiens_hsa053400.94509567
49Propanoate metabolism_Homo sapiens_hsa006400.93867299
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.88680882
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.87391570
52Regulation of autophagy_Homo sapiens_hsa041400.86737518
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85763060
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.84303309
55Amphetamine addiction_Homo sapiens_hsa050310.82705715
56Oxytocin signaling pathway_Homo sapiens_hsa049210.77881149
57cAMP signaling pathway_Homo sapiens_hsa040240.76703981
58Selenocompound metabolism_Homo sapiens_hsa004500.76359283
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76214082
60Chemical carcinogenesis_Homo sapiens_hsa052040.75136513
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72730668
62Antigen processing and presentation_Homo sapiens_hsa046120.71315922
63Basal transcription factors_Homo sapiens_hsa030220.70832079
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70017796
65Synaptic vesicle cycle_Homo sapiens_hsa047210.68387677
66Long-term depression_Homo sapiens_hsa047300.66300259
67Gastric acid secretion_Homo sapiens_hsa049710.65717934
68Fanconi anemia pathway_Homo sapiens_hsa034600.65436189
69Hedgehog signaling pathway_Homo sapiens_hsa043400.65198865
70Type II diabetes mellitus_Homo sapiens_hsa049300.64843511
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.63254660
72Rheumatoid arthritis_Homo sapiens_hsa053230.62851289
73Arachidonic acid metabolism_Homo sapiens_hsa005900.60679575
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60543292
75Asthma_Homo sapiens_hsa053100.60231192
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.59779153
77Peroxisome_Homo sapiens_hsa041460.53825340
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52693735
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51194696
80Fat digestion and absorption_Homo sapiens_hsa049750.51126800
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50268488
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48979352
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.47672263
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46975085
85Oocyte meiosis_Homo sapiens_hsa041140.45532148
86Glycerolipid metabolism_Homo sapiens_hsa005610.45307003
87Ovarian steroidogenesis_Homo sapiens_hsa049130.44516580
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44472343
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42724629
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41025867
91N-Glycan biosynthesis_Homo sapiens_hsa005100.39969224
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39751759
93Bile secretion_Homo sapiens_hsa049760.38541301
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37241757
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36955867
96Hematopoietic cell lineage_Homo sapiens_hsa046400.34524463
97Metabolic pathways_Homo sapiens_hsa011000.34115486
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33760425
99Cocaine addiction_Homo sapiens_hsa050300.33684708
100Protein digestion and absorption_Homo sapiens_hsa049740.32089820

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