RGPD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* establishment of protein localization to Golgi (GO:0072600)8.42551426
2* protein targeting to Golgi (GO:0000042)8.31321273
3* retrograde transport, vesicle recycling within Golgi (GO:0000301)7.78916226
4sperm motility (GO:0030317)6.45905782
5acrosome reaction (GO:0007340)6.44764184
6* protein localization to Golgi apparatus (GO:0034067)5.98768667
7protein polyglutamylation (GO:0018095)4.99577685
8fusion of sperm to egg plasma membrane (GO:0007342)4.90663543
9microtubule depolymerization (GO:0007019)4.84420034
10single strand break repair (GO:0000012)4.83349411
11centriole replication (GO:0007099)4.76221117
12response to pheromone (GO:0019236)4.76161000
13regulation of centriole replication (GO:0046599)4.72540044
14multicellular organism reproduction (GO:0032504)4.21457978
15spermatid development (GO:0007286)4.09510600
16microtubule polymerization or depolymerization (GO:0031109)4.07392764
17* intra-Golgi vesicle-mediated transport (GO:0006891)4.04084083
18DNA packaging (GO:0006323)3.94389481
19nuclear pore complex assembly (GO:0051292)3.90385540
20Golgi to endosome transport (GO:0006895)3.86229175
21plasma membrane fusion (GO:0045026)3.78452982
22microtubule nucleation (GO:0007020)3.77653909
23phosphatidylethanolamine biosynthetic process (GO:0006646)3.73062865
24chromosome condensation (GO:0030261)3.72938999
25sperm-egg recognition (GO:0035036)3.72372397
26cilium or flagellum-dependent cell motility (GO:0001539)3.68843746
27spermatid nucleus differentiation (GO:0007289)3.64719760
28regulation of glucokinase activity (GO:0033131)3.64240197
29regulation of hexokinase activity (GO:1903299)3.64240197
30protein K11-linked deubiquitination (GO:0035871)3.62202116
31cellular ketone body metabolic process (GO:0046950)3.56865766
32histone mRNA catabolic process (GO:0071044)3.56047570
33phosphatidylethanolamine metabolic process (GO:0046337)3.54123051
34centriole assembly (GO:0098534)3.52055466
35sperm capacitation (GO:0048240)3.51310424
36spermatogenesis (GO:0007283)3.50255516
37male gamete generation (GO:0048232)3.49855429
38regulation of Rab GTPase activity (GO:0032313)3.45779147
39positive regulation of Rab GTPase activity (GO:0032851)3.45779147
40calcium ion-dependent exocytosis (GO:0017156)3.42650826
41reproduction (GO:0000003)3.40998392
42epithelial cilium movement (GO:0003351)3.36599684
43early endosome to late endosome transport (GO:0045022)3.31278318
44glomerular visceral epithelial cell development (GO:0072015)3.30836875
45histone H3-K9 demethylation (GO:0033169)3.29652282
46receptor recycling (GO:0001881)3.28707533
47photoreceptor cell maintenance (GO:0045494)3.28230581
48gamete generation (GO:0007276)3.28163410
49seminiferous tubule development (GO:0072520)3.27532581
50musculoskeletal movement (GO:0050881)3.24010217
51multicellular organismal movement (GO:0050879)3.24010217
52righting reflex (GO:0060013)3.22398620
53nuclear pore organization (GO:0006999)3.16028990
54phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.15716232
55protein K48-linked deubiquitination (GO:0071108)3.15346064
56cell-cell recognition (GO:0009988)3.12192733
57ketone body metabolic process (GO:1902224)3.11628679
58rRNA methylation (GO:0031167)3.08333628
59binding of sperm to zona pellucida (GO:0007339)3.08050438
60pore complex assembly (GO:0046931)3.06748584
61monoubiquitinated protein deubiquitination (GO:0035520)3.02310111
62regulation of cilium movement (GO:0003352)3.01472234
63protein-chromophore linkage (GO:0018298)3.00156063
64regulation of transcription involved in cell fate commitment (GO:0060850)2.99775703
65negative regulation of inclusion body assembly (GO:0090084)2.92887484
66axonemal dynein complex assembly (GO:0070286)2.90496518
67cilium movement (GO:0003341)2.90197496
68cellular response to ethanol (GO:0071361)2.89363388
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88962749
70glomerular epithelial cell development (GO:0072310)2.87511185
71nucleus organization (GO:0006997)2.87387106
72regulation of centrosome duplication (GO:0010824)2.85570234
73regulation of meiosis I (GO:0060631)2.84860562
74peptidyl-threonine dephosphorylation (GO:0035970)2.83610846
75artery development (GO:0060840)2.83574966
76genitalia morphogenesis (GO:0035112)2.82432558
77single fertilization (GO:0007338)2.79602904
78vesicle transport along microtubule (GO:0047496)2.78450390
79negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.77329989
80negative regulation of translation, ncRNA-mediated (GO:0040033)2.77329989
81regulation of translation, ncRNA-mediated (GO:0045974)2.77329989
82positive regulation of glycolytic process (GO:0045821)2.75158452
83cell wall macromolecule catabolic process (GO:0016998)2.74633842
84axoneme assembly (GO:0035082)2.69608340
85RNA destabilization (GO:0050779)2.65664981
86embryonic retina morphogenesis in camera-type eye (GO:0060059)2.61417124
87germ cell development (GO:0007281)2.59283998
88negative regulation of Rho protein signal transduction (GO:0035024)2.58860778
89multicellular organismal reproductive process (GO:0048609)2.58466596
90coronary vasculature morphogenesis (GO:0060977)2.57489409
91microtubule severing (GO:0051013)2.56110497
92appendage development (GO:0048736)2.54185568
93limb development (GO:0060173)2.54185568
94regulation of establishment of cell polarity (GO:2000114)2.54156493
95cAMP catabolic process (GO:0006198)2.53715676
96inositol phosphate catabolic process (GO:0071545)2.52173170
97phosphorylated carbohydrate dephosphorylation (GO:0046838)2.51868300
98inositol phosphate dephosphorylation (GO:0046855)2.51868300
99centrosome duplication (GO:0051298)2.50475319
100cilium organization (GO:0044782)2.49592948

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.09587017
2SALL1_21062744_ChIP-ChIP_HESCs_Human2.95165989
3FUS_26573619_Chip-Seq_HEK293_Human2.78645868
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71204084
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.67210030
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66708679
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64321640
8TAF15_26573619_Chip-Seq_HEK293_Human2.49152788
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33491775
10P300_19829295_ChIP-Seq_ESCs_Human2.27629488
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24416012
12VDR_22108803_ChIP-Seq_LS180_Human2.22927640
13AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.22891946
14IGF1R_20145208_ChIP-Seq_DFB_Human2.19676647
15ZNF274_21170338_ChIP-Seq_K562_Hela2.17070712
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.12820966
17IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.09564861
18CBP_20019798_ChIP-Seq_JUKART_Human2.09564861
19SMAD4_21799915_ChIP-Seq_A2780_Human2.07887953
20ER_23166858_ChIP-Seq_MCF-7_Human2.04284979
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00044076
22STAT3_23295773_ChIP-Seq_U87_Human1.96793623
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96185335
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87738183
25SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.85946702
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.85768854
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85768854
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.84596884
29SMAD3_21741376_ChIP-Seq_EPCs_Human1.84340588
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.83648517
31AR_25329375_ChIP-Seq_VCAP_Human1.74510822
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72942011
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72585254
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70066357
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.69615987
36TCF4_23295773_ChIP-Seq_U87_Human1.66406376
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.66187897
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66176884
39EWS_26573619_Chip-Seq_HEK293_Human1.62532003
40AR_21572438_ChIP-Seq_LNCaP_Human1.60442484
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60184530
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55528047
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52513453
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50704454
45AHR_22903824_ChIP-Seq_MCF-7_Human1.48469197
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.47886446
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46407845
48RUNX2_22187159_ChIP-Seq_PCA_Human1.45093146
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.44196222
50* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44069623
51TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.42398322
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41957545
53TP53_18474530_ChIP-ChIP_U2OS_Human1.41800730
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41800170
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41677994
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.40466138
57* SMAD4_21741376_ChIP-Seq_EPCs_Human1.38432144
58BCAT_22108803_ChIP-Seq_LS180_Human1.32385546
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.31960789
60TCF4_22108803_ChIP-Seq_LS180_Human1.30172747
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29109184
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29071668
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27329837
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26527198
65* CDX2_22108803_ChIP-Seq_LS180_Human1.25913073
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.25654592
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.24792448
68CJUN_26792858_Chip-Seq_BT549_Human1.22214910
69CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21994385
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.21248853
71TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.20690715
72TBL1_22424771_ChIP-Seq_293T_Human1.20540696
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20203641
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19426182
75SOX2_19829295_ChIP-Seq_ESCs_Human1.18852025
76NANOG_19829295_ChIP-Seq_ESCs_Human1.18852025
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.18762303
78KDM2B_26808549_Chip-Seq_REH_Human1.18106347
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17940216
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17356298
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.17195802
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13419965
83SMAD4_21741376_ChIP-Seq_HESCs_Human1.13084316
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10837554
85TP53_16413492_ChIP-PET_HCT116_Human1.10550207
86NFYB_21822215_ChIP-Seq_K562_Human1.08266772
87SMAD3_21741376_ChIP-Seq_ESCs_Human1.07656504
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06944821
89P53_22387025_ChIP-Seq_ESCs_Mouse1.06350983
90ETV1_20927104_ChIP-Seq_GIST48_Human1.06084808
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05731502
92OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04297112
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03228228
94DROSHA_22980978_ChIP-Seq_HELA_Human1.02756950
95TP63_23658742_ChIP-Seq_EP156T_Human1.01960135
96P300_18555785_Chip-Seq_ESCs_Mouse1.01770296
97FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01312813
98NFYA_21822215_ChIP-Seq_K562_Human1.01183739
99OCT4_18555785_Chip-Seq_ESCs_Mouse1.00411582
100CMYC_18555785_Chip-Seq_ESCs_Mouse0.99469511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.10797559
2MP0003011_delayed_dark_adaptation3.27178669
3MP0000569_abnormal_digit_pigmentation3.01692455
4MP0008057_abnormal_DNA_replication3.00302248
5MP0005083_abnormal_biliary_tract2.92889337
6MP0005670_abnormal_white_adipose2.60658156
7MP0002638_abnormal_pupillary_reflex2.42667436
8MP0003698_abnormal_male_reproductive2.38403124
9MP0008004_abnormal_stomach_pH2.37828912
10MP0005379_endocrine/exocrine_gland_phen2.31408859
11MP0002928_abnormal_bile_duct2.28268815
12MP0009780_abnormal_chondrocyte_physiolo2.28259578
13MP0005253_abnormal_eye_physiology2.24242856
14MP0001929_abnormal_gametogenesis2.19612955
15MP0005084_abnormal_gallbladder_morpholo2.18836771
16MP0003195_calcinosis2.05470709
17MP0003878_abnormal_ear_physiology2.02772964
18MP0005377_hearing/vestibular/ear_phenot2.02772964
19MP0005551_abnormal_eye_electrophysiolog1.97076740
20MP0008877_abnormal_DNA_methylation1.92760021
21MP0005085_abnormal_gallbladder_physiolo1.71276563
22MP0001486_abnormal_startle_reflex1.62206193
23MP0001666_abnormal_nutrient_absorption1.57464913
24MP0003646_muscle_fatigue1.57433152
25MP0002138_abnormal_hepatobiliary_system1.47359058
26MP0006072_abnormal_retinal_apoptosis1.44797835
27MP0005365_abnormal_bile_salt1.38313554
28MP0009046_muscle_twitch1.37829739
29MP0005310_abnormal_salivary_gland1.34985890
30MP0000427_abnormal_hair_cycle1.33993114
31MP0003943_abnormal_hepatobiliary_system1.31935011
32MP0003868_abnormal_feces_composition1.28352618
33MP0003950_abnormal_plasma_membrane1.27100969
34MP0000383_abnormal_hair_follicle1.26920962
35MP0003718_maternal_effect1.25495414
36MP0002102_abnormal_ear_morphology1.25422417
37MP0002168_other_aberrant_phenotype1.17044681
38MP0004484_altered_response_of1.16962075
39MP0005391_vision/eye_phenotype1.15509936
40MP0002161_abnormal_fertility/fecundity1.14999359
41MP0009697_abnormal_copulation1.13556021
42MP0008961_abnormal_basal_metabolism1.12306500
43MP0005395_other_phenotype1.10639368
44MP0001984_abnormal_olfaction1.10185025
45MP0010678_abnormal_skin_adnexa1.08213185
46MP0004264_abnormal_extraembryonic_tissu1.08090901
47MP0010307_abnormal_tumor_latency1.07755934
48MP0001501_abnormal_sleep_pattern1.07636515
49MP0005367_renal/urinary_system_phenotyp1.06925199
50MP0000516_abnormal_urinary_system1.06925199
51MP0002234_abnormal_pharynx_morphology1.06429918
52MP0002282_abnormal_trachea_morphology1.04326641
53MP0003252_abnormal_bile_duct1.03430204
54MP0003787_abnormal_imprinting1.02583310
55MP0002127_abnormal_cardiovascular_syste1.01484519
56MP0005647_abnormal_sex_gland0.99523797
57MP0002210_abnormal_sex_determination0.98544223
58MP0005187_abnormal_penis_morphology0.97958634
59MP0002229_neurodegeneration0.97455295
60MP0001485_abnormal_pinna_reflex0.94237710
61MP0010386_abnormal_urinary_bladder0.93527627
62MP0006292_abnormal_olfactory_placode0.92966934
63MP0001299_abnormal_eye_distance/0.92850169
64MP0006054_spinal_hemorrhage0.92351877
65MP0003890_abnormal_embryonic-extraembry0.89146156
66MP0004084_abnormal_cardiac_muscle0.88085552
67MP0009115_abnormal_fat_cell0.87696565
68MP0003122_maternal_imprinting0.86561575
69MP0000653_abnormal_sex_gland0.84783183
70MP0004085_abnormal_heartbeat0.84659710
71MP0002067_abnormal_sensory_capabilities0.81408417
72MP0004742_abnormal_vestibular_system0.81217181
73MP0005386_behavior/neurological_phenoty0.81020966
74MP0004924_abnormal_behavior0.81020966
75MP0002269_muscular_atrophy0.80918667
76MP0001145_abnormal_male_reproductive0.79326893
77MP0003121_genomic_imprinting0.78648518
78MP0000013_abnormal_adipose_tissue0.77529199
79MP0004215_abnormal_myocardial_fiber0.77392742
80MP0002557_abnormal_social/conspecific_i0.75208772
81MP0003045_fibrosis0.74223895
82MP0001348_abnormal_lacrimal_gland0.74001621
83MP0001879_abnormal_lymphatic_vessel0.73368898
84MP0004134_abnormal_chest_morphology0.72874900
85MP0005220_abnormal_exocrine_pancreas0.72694315
86MP0003937_abnormal_limbs/digits/tail_de0.70941843
87MP0010352_gastrointestinal_tract_polyps0.70722367
88MP0001270_distended_abdomen0.70668167
89MP0008775_abnormal_heart_ventricle0.70499161
90MP0001502_abnormal_circadian_rhythm0.68958659
91MP0000465_gastrointestinal_hemorrhage0.68799480
92MP0002572_abnormal_emotion/affect_behav0.68154772
93MP0001963_abnormal_hearing_physiology0.67898835
94MP0009745_abnormal_behavioral_response0.65111872
95MP0002254_reproductive_system_inflammat0.64960360
96MP0001440_abnormal_grooming_behavior0.64277948
97MP0009703_decreased_birth_body0.64005947
98MP0002184_abnormal_innervation0.63954671
99MP0000955_abnormal_spinal_cord0.63815251
100MP0001765_abnormal_ion_homeostasis0.63333460

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)5.20477457
2Chronic hepatic failure (HP:0100626)5.07112202
3Volvulus (HP:0002580)3.67551717
4Nephronophthisis (HP:0000090)3.53617365
5Abnormality of the renal medulla (HP:0100957)3.50288311
6Hyperkalemia (HP:0002153)3.49455521
7Truncal obesity (HP:0001956)3.45785296
8Abnormality of the ischium (HP:0003174)3.30320992
9Abnormality of the renal cortex (HP:0011035)3.30257602
10Cone-rod dystrophy (HP:0000548)3.26300666
11Hypoplastic ischia (HP:0003175)3.10743374
12Tubular atrophy (HP:0000092)3.10524306
13Attenuation of retinal blood vessels (HP:0007843)3.07280465
14Hyperventilation (HP:0002883)3.03610168
15Severe visual impairment (HP:0001141)3.02739994
16Tubulointerstitial abnormality (HP:0001969)2.82916110
17Menstrual irregularities (HP:0000858)2.76886660
18Bony spicule pigmentary retinopathy (HP:0007737)2.76283482
19Abnormality of macular pigmentation (HP:0008002)2.69451121
20Hypoalphalipoproteinemia (HP:0003233)2.68558985
21Progressive cerebellar ataxia (HP:0002073)2.66341696
22Stage 5 chronic kidney disease (HP:0003774)2.53377450
23Abnormal hair whorl (HP:0010721)2.52692596
24Enlarged epiphyses (HP:0010580)2.52575548
25Gaze-evoked nystagmus (HP:0000640)2.52081684
26Drooling (HP:0002307)2.51836996
27Progressive sensorineural hearing impairment (HP:0000408)2.46441387
28Pancreatic cysts (HP:0001737)2.42830382
29Intestinal atresia (HP:0011100)2.37615860
30Portal hypertension (HP:0001409)2.34090887
31Abnormal biliary tract morphology (HP:0012440)2.25059935
32Abnormality of the nasal septum (HP:0000419)2.24622561
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.24412740
34Absent/shortened dynein arms (HP:0200106)2.24412740
35Excessive salivation (HP:0003781)2.22571255
36Resting tremor (HP:0002322)2.20462063
37Submucous cleft hard palate (HP:0000176)2.19889018
38Febrile seizures (HP:0002373)2.18258066
39Insulin-resistant diabetes mellitus (HP:0000831)2.17925490
40Abnormality of the astrocytes (HP:0100707)2.16340856
41Astrocytoma (HP:0009592)2.16340856
42Papillary thyroid carcinoma (HP:0002895)2.16311768
43Pancreatic fibrosis (HP:0100732)2.14909132
44Widely spaced teeth (HP:0000687)2.13995959
45Abnormality of the hepatic vasculature (HP:0006707)2.08657611
46Abnormal drinking behavior (HP:0030082)2.07153251
47Polydipsia (HP:0001959)2.07153251
48Renal cortical cysts (HP:0000803)2.07134243
49Abnormal pancreas size (HP:0012094)2.04166743
50Bell-shaped thorax (HP:0001591)2.01858485
51Hypoglycemic seizures (HP:0002173)2.01094766
52Thyroiditis (HP:0100646)2.00376306
53Azoospermia (HP:0000027)2.00027406
54Intellectual disability, moderate (HP:0002342)1.99575917
55Biliary tract neoplasm (HP:0100574)1.97372527
56Abnormality of potassium homeostasis (HP:0011042)1.96292196
57Hypoplastic iliac wings (HP:0002866)1.95645990
58Glioma (HP:0009733)1.95516183
59Narrow palate (HP:0000189)1.94306387
60Aplasia/Hypoplasia of the earlobes (HP:0009906)1.93786444
61Congenital sensorineural hearing impairment (HP:0008527)1.93174453
62Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90169978
63Fair hair (HP:0002286)1.89917430
64Hypoplasia of the thymus (HP:0000778)1.87649656
65Renovascular hypertension (HP:0100817)1.87475169
66Absent speech (HP:0001344)1.87042020
67Abnormal spermatogenesis (HP:0008669)1.87040236
68Heterotopia (HP:0002282)1.85684729
69Downturned corners of mouth (HP:0002714)1.85231204
70Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83109413
71Asymmetric septal hypertrophy (HP:0001670)1.82726497
72Aplasia/Hypoplasia of the tibia (HP:0005772)1.81096759
73Cerebellar dysplasia (HP:0007033)1.80565727
74Genetic anticipation (HP:0003743)1.79443766
75Abnormality of the parathyroid morphology (HP:0011766)1.78245436
76Type II diabetes mellitus (HP:0005978)1.77582191
77Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.76497029
78Congenital malformation of the right heart (HP:0011723)1.76420344
79Double outlet right ventricle (HP:0001719)1.76420344
80Neoplasm of the oral cavity (HP:0100649)1.75599060
81Atonic seizures (HP:0010819)1.73159044
82Abnormality of midbrain morphology (HP:0002418)1.71874423
83Molar tooth sign on MRI (HP:0002419)1.71874423
84Congenital hepatic fibrosis (HP:0002612)1.70448440
85True hermaphroditism (HP:0010459)1.70021124
86Postural instability (HP:0002172)1.69466729
87Abnormality of the epiphyses of the hand (HP:0005924)1.68686535
88Abnormality of chloride homeostasis (HP:0011422)1.65737581
89Cystic liver disease (HP:0006706)1.64325635
90Spastic tetraplegia (HP:0002510)1.63117293
91Abnormal biliary tract physiology (HP:0012439)1.63007305
92Bile duct proliferation (HP:0001408)1.63007305
93Tetraplegia (HP:0002445)1.62614042
94Cupped ear (HP:0000378)1.62333308
95Sandal gap (HP:0001852)1.61766178
96Growth hormone deficiency (HP:0000824)1.61620458
97Progressive inability to walk (HP:0002505)1.61605019
98Increased CSF protein (HP:0002922)1.60269832
99Polyuria (HP:0000103)1.59871582
100Increased corneal curvature (HP:0100692)1.59579850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.44655524
2PLK44.14850746
3BRD43.90396091
4PNCK3.35136399
5AKT32.85134280
6CAMK1G2.83779216
7INSRR2.75588638
8MAP4K22.38659608
9STK38L2.34576044
10ACVR1B2.21548594
11BMPR1B2.15271559
12CDK122.01067681
13MAP3K41.97726141
14PLK21.92205733
15CAMK1D1.88584584
16WNK41.79108939
17WNK11.77315688
18MST1R1.73119201
19CASK1.65147333
20STK391.64405461
21PIK3CG1.62728049
22LATS11.53680120
23TNIK1.52142111
24NME11.34018210
25EIF2AK31.33901207
26MKNK21.33630142
27ERBB31.30030101
28OXSR11.21998594
29FGFR21.17671709
30STK381.14212079
31NEK61.13848337
32WNK31.10170681
33SGK21.04653375
34MET1.04266134
35OBSCN1.01483084
36DDR21.01284417
37TRPM70.96687419
38PINK10.95169051
39PTK2B0.88443193
40NLK0.86599711
41NUAK10.85657791
42PAK30.81671139
43NTRK30.81425978
44MKNK10.78296487
45MARK10.77986225
46PRKAA20.77482981
47FER0.77457368
48MAPK130.77103128
49STK30.73783444
50TRIM280.72672672
51ZAK0.70501761
52BCR0.66301432
53PIK3CA0.65619129
54MAP3K60.62628337
55CAMK40.61322454
56CDK30.61003117
57BLK0.60478464
58SGK4940.57816083
59SGK2230.57816083
60PDGFRB0.57152112
61PRKG10.56895054
62MAP3K20.56280575
63PRKCE0.54930558
64SGK30.54283104
65PDK10.53647532
66PRKAA10.53319303
67ATM0.52529195
68SGK10.52474603
69BRSK20.51434263
70TEC0.47194043
71CHEK10.45993274
72MAP2K70.44854298
73FGFR30.44473284
74ROCK10.44302781
75CAMK10.43598099
76GSK3B0.43228310
77MAP3K70.43005994
78CHUK0.42554600
79YES10.41670799
80PRKACB0.41402728
81PRKCG0.40724640
82CSNK1D0.40273931
83MAPK10.40178983
84TIE10.38926960
85GRK10.37819259
86EPHA30.37813891
87* CDK10.37360098
88TGFBR10.36346072
89CAMKK20.33920381
90ADRBK20.33443986
91MAPK140.32439328
92MST40.31351894
93PRKCB0.31128110
94ERBB40.30780916
95FGFR10.30120645
96PHKG10.29791659
97PHKG20.29791659
98TESK10.29538179
99MAP2K60.28995215
100RPS6KA30.28316470

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.68721917
2Fatty acid biosynthesis_Homo sapiens_hsa000613.14804027
3Circadian rhythm_Homo sapiens_hsa047102.38965435
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.36194385
5Dorso-ventral axis formation_Homo sapiens_hsa043202.27466665
6Butanoate metabolism_Homo sapiens_hsa006502.08841120
7Olfactory transduction_Homo sapiens_hsa047402.03550034
8Selenocompound metabolism_Homo sapiens_hsa004502.01472426
9Lysine degradation_Homo sapiens_hsa003101.86581430
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.84846428
11Taste transduction_Homo sapiens_hsa047421.79635392
12Non-homologous end-joining_Homo sapiens_hsa034501.77965850
13ABC transporters_Homo sapiens_hsa020101.67737580
14Inositol phosphate metabolism_Homo sapiens_hsa005621.64901144
15Phosphatidylinositol signaling system_Homo sapiens_hsa040701.64294087
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.60775082
17Phototransduction_Homo sapiens_hsa047441.53276237
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.50842034
19Type II diabetes mellitus_Homo sapiens_hsa049301.50576972
20Regulation of autophagy_Homo sapiens_hsa041401.45872083
21Basal transcription factors_Homo sapiens_hsa030221.45679301
22Fanconi anemia pathway_Homo sapiens_hsa034601.44933466
23Oocyte meiosis_Homo sapiens_hsa041141.34095263
24* RNA transport_Homo sapiens_hsa030131.26958722
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25572595
26Salivary secretion_Homo sapiens_hsa049701.23309186
27Insulin secretion_Homo sapiens_hsa049111.20127841
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17477842
29TGF-beta signaling pathway_Homo sapiens_hsa043501.14664454
30Nicotine addiction_Homo sapiens_hsa050331.09247746
31Protein digestion and absorption_Homo sapiens_hsa049741.08887301
32Glutamatergic synapse_Homo sapiens_hsa047241.04707017
33Circadian entrainment_Homo sapiens_hsa047131.04580643
34Propanoate metabolism_Homo sapiens_hsa006401.04324249
35Calcium signaling pathway_Homo sapiens_hsa040200.96707470
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95611591
37Retinol metabolism_Homo sapiens_hsa008300.95083476
38Renin secretion_Homo sapiens_hsa049240.94973249
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93923442
40Steroid hormone biosynthesis_Homo sapiens_hsa001400.93558113
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91573475
42Glycerophospholipid metabolism_Homo sapiens_hsa005640.91566738
43Nitrogen metabolism_Homo sapiens_hsa009100.91423970
44Serotonergic synapse_Homo sapiens_hsa047260.91383659
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90407423
46Linoleic acid metabolism_Homo sapiens_hsa005910.90049356
47ECM-receptor interaction_Homo sapiens_hsa045120.86611174
48Morphine addiction_Homo sapiens_hsa050320.85917939
49Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84794415
50Fatty acid metabolism_Homo sapiens_hsa012120.83168692
51cAMP signaling pathway_Homo sapiens_hsa040240.82940496
52Pancreatic secretion_Homo sapiens_hsa049720.80700335
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79928682
54RNA degradation_Homo sapiens_hsa030180.79629156
55FoxO signaling pathway_Homo sapiens_hsa040680.76357405
56Adherens junction_Homo sapiens_hsa045200.75567261
57Tryptophan metabolism_Homo sapiens_hsa003800.74460357
58Tight junction_Homo sapiens_hsa045300.72375995
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71993780
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.70476393
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70274229
62Ether lipid metabolism_Homo sapiens_hsa005650.69900842
63Thyroid hormone synthesis_Homo sapiens_hsa049180.69235246
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68080039
65Long-term depression_Homo sapiens_hsa047300.67723513
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66977706
67Fatty acid degradation_Homo sapiens_hsa000710.66646901
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64989241
69Glycerolipid metabolism_Homo sapiens_hsa005610.64959832
70mTOR signaling pathway_Homo sapiens_hsa041500.64611787
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64547564
72Hedgehog signaling pathway_Homo sapiens_hsa043400.64403443
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61232339
74Gastric acid secretion_Homo sapiens_hsa049710.57549922
75Sphingolipid metabolism_Homo sapiens_hsa006000.57039414
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56081866
77GABAergic synapse_Homo sapiens_hsa047270.55377820
78Glucagon signaling pathway_Homo sapiens_hsa049220.54520029
79Dopaminergic synapse_Homo sapiens_hsa047280.53528326
80Cholinergic synapse_Homo sapiens_hsa047250.52879365
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.52496656
82mRNA surveillance pathway_Homo sapiens_hsa030150.46055243
83Prolactin signaling pathway_Homo sapiens_hsa049170.46018630
84Hippo signaling pathway_Homo sapiens_hsa043900.43543580
85Insulin resistance_Homo sapiens_hsa049310.42997200
86Prostate cancer_Homo sapiens_hsa052150.42324764
87PPAR signaling pathway_Homo sapiens_hsa033200.42271234
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42137097
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41380819
90MicroRNAs in cancer_Homo sapiens_hsa052060.41141259
91Platelet activation_Homo sapiens_hsa046110.41062488
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40051163
93Oxytocin signaling pathway_Homo sapiens_hsa049210.39966290
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39699966
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.39368704
96Ovarian steroidogenesis_Homo sapiens_hsa049130.39137107
97Mineral absorption_Homo sapiens_hsa049780.38792374
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37808525
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37525484
100Estrogen signaling pathway_Homo sapiens_hsa049150.37040388

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