RGR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fat-soluble vitamin metabolic process (GO:0006775)8.61657765
2tyrosine metabolic process (GO:0006570)8.44451958
3detection of light stimulus involved in sensory perception (GO:0050962)8.04498139
4detection of light stimulus involved in visual perception (GO:0050908)8.04498139
5primary alcohol metabolic process (GO:0034308)6.98018362
6retinoic acid metabolic process (GO:0042573)6.03993191
7camera-type eye morphogenesis (GO:0048593)5.27429167
8secondary metabolic process (GO:0019748)5.12533533
9phototransduction, visible light (GO:0007603)4.99287575
10cellular aldehyde metabolic process (GO:0006081)4.91595028
11phenol-containing compound biosynthetic process (GO:0046189)4.82329866
12retinoid metabolic process (GO:0001523)4.81677996
13retina homeostasis (GO:0001895)4.66098142
14diterpenoid metabolic process (GO:0016101)4.49896959
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.47789544
16tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.47789544
17tachykinin receptor signaling pathway (GO:0007217)4.45531056
18mitochondrion distribution (GO:0048311)4.45137077
19* phototransduction (GO:0007602)4.45125888
20melanocyte differentiation (GO:0030318)4.29592171
21detection of visible light (GO:0009584)4.28751382
22diterpenoid biosynthetic process (GO:0016102)4.16750510
23terpenoid metabolic process (GO:0006721)4.15753055
24homocysteine metabolic process (GO:0050667)4.13263562
25primary amino compound metabolic process (GO:1901160)4.03005472
26* detection of light stimulus (GO:0009583)4.02142677
27vitamin A metabolic process (GO:0006776)33.7022475
28bicarbonate transport (GO:0015701)3.98855931
29ear development (GO:0043583)3.97096475
30indole-containing compound catabolic process (GO:0042436)3.92504090
31indolalkylamine catabolic process (GO:0046218)3.92504090
32tryptophan catabolic process (GO:0006569)3.92504090
33microtubule nucleation (GO:0007020)3.92104116
34pigment cell differentiation (GO:0050931)3.90756760
35photoreceptor cell maintenance (GO:0045494)3.90588132
36adenosine metabolic process (GO:0046085)3.88804571
37gamma-aminobutyric acid transport (GO:0015812)3.83322404
38behavioral response to nicotine (GO:0035095)3.76535127
39cilium or flagellum-dependent cell motility (GO:0001539)3.74699626
40response to electrical stimulus (GO:0051602)3.73205145
41ketone body metabolic process (GO:1902224)3.72055349
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.69327765
43indolalkylamine metabolic process (GO:0006586)3.64404024
44retinal rod cell development (GO:0046548)3.56285677
45kynurenine metabolic process (GO:0070189)3.51805070
46cochlea development (GO:0090102)3.50035600
47cysteine metabolic process (GO:0006534)3.45197201
48sulfur amino acid catabolic process (GO:0000098)3.40150887
49adaptation of signaling pathway (GO:0023058)3.37621819
50isoprenoid metabolic process (GO:0006720)3.34796241
51* visual perception (GO:0007601)3.33060729
52behavioral response to ethanol (GO:0048149)3.31105066
53* sensory perception of light stimulus (GO:0050953)3.28451491
54negative regulation of cytosolic calcium ion concentration (GO:0051481)3.24924941
55positive regulation of oligodendrocyte differentiation (GO:0048714)3.24776027
56tryptophan metabolic process (GO:0006568)3.24291772
57keratan sulfate catabolic process (GO:0042340)3.24269240
58auditory receptor cell stereocilium organization (GO:0060088)3.21153547
59regulation of plasminogen activation (GO:0010755)3.18528192
60indole-containing compound metabolic process (GO:0042430)3.17462070
61acrosome assembly (GO:0001675)3.16850293
62inner ear receptor cell development (GO:0060119)3.16121843
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.14981312
64response to pheromone (GO:0019236)3.12357251
65cellular hormone metabolic process (GO:0034754)3.12347860
66negative regulation of keratinocyte proliferation (GO:0010839)3.09555964
67pigment biosynthetic process (GO:0046148)3.07380457
68white fat cell differentiation (GO:0050872)3.06698527
69behavioral defense response (GO:0002209)3.05710366
70behavioral fear response (GO:0001662)3.05710366
71reflex (GO:0060004)3.05419470
72positive regulation of guanylate cyclase activity (GO:0031284)3.01678827
73platelet dense granule organization (GO:0060155)3.01214949
74postsynaptic membrane organization (GO:0001941)3.00316538
75regulation of skeletal muscle contraction (GO:0014819)2.97006442
76developmental pigmentation (GO:0048066)2.94827015
77aromatic amino acid family metabolic process (GO:0009072)2.93807844
78terpenoid biosynthetic process (GO:0016114)2.93479485
79icosanoid secretion (GO:0032309)2.92437894
80arachidonic acid secretion (GO:0050482)2.92437894
81retinal cone cell development (GO:0046549)2.90521847
82folic acid-containing compound biosynthetic process (GO:0009396)2.90503365
83mitochondrial RNA metabolic process (GO:0000959)2.90421719
84* detection of external stimulus (GO:0009581)2.90412387
85regulation of sarcomere organization (GO:0060297)2.86949426
86epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.84553758
87righting reflex (GO:0060013)2.84452205
88* detection of abiotic stimulus (GO:0009582)2.82229876
89positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.79749773
90photoreceptor cell development (GO:0042461)2.79696895
91eye photoreceptor cell differentiation (GO:0001754)2.75173399
92photoreceptor cell differentiation (GO:0046530)2.75173399
93positive regulation of neuroblast proliferation (GO:0002052)2.74427488
94regulation of gonadotropin secretion (GO:0032276)2.74310921
95embryonic viscerocranium morphogenesis (GO:0048703)2.73514300
96fear response (GO:0042596)2.72946977
97negative regulation of stress fiber assembly (GO:0051497)2.71665075
98axoneme assembly (GO:0035082)2.71129013
99L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70561475
100organic cation transport (GO:0015695)2.70401180
101adult feeding behavior (GO:0008343)2.70113685
102cellular ketone body metabolic process (GO:0046950)2.68004108
103inner ear receptor stereocilium organization (GO:0060122)2.67471344
104fucose catabolic process (GO:0019317)2.67326078
105L-fucose metabolic process (GO:0042354)2.67326078
106L-fucose catabolic process (GO:0042355)2.67326078
107phosphatidylglycerol biosynthetic process (GO:0006655)2.65358020
108neuroepithelial cell differentiation (GO:0060563)2.64696932
109eye photoreceptor cell development (GO:0042462)2.64399171
110neuronal action potential propagation (GO:0019227)2.62572176
111regulation of guanylate cyclase activity (GO:0031282)2.62119702
112neural tube formation (GO:0001841)2.61766652
113positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.61714642
114regulation of sequestering of triglyceride (GO:0010889)2.58675143
115cellular biogenic amine catabolic process (GO:0042402)2.54204356
116amine catabolic process (GO:0009310)2.54204356
117heme transport (GO:0015886)2.52455684
118piRNA metabolic process (GO:0034587)2.52428950
119icosanoid transport (GO:0071715)2.51014627
120fatty acid derivative transport (GO:1901571)2.51014627
121innervation (GO:0060384)2.50233250
122cornea development in camera-type eye (GO:0061303)2.47458181
123sulfur amino acid biosynthetic process (GO:0000097)2.46972795
124establishment of protein localization to Golgi (GO:0072600)2.46870794
125protein-cofactor linkage (GO:0018065)2.46169807
126nonmotile primary cilium assembly (GO:0035058)2.45990292
127benzene-containing compound metabolic process (GO:0042537)2.42631769
128amino acid salvage (GO:0043102)2.42423651
129L-methionine salvage (GO:0071267)2.42423651
130L-methionine biosynthetic process (GO:0071265)2.42423651
131C4-dicarboxylate transport (GO:0015740)2.42347632
132negative regulation of DNA biosynthetic process (GO:2000279)2.41012131
133preassembly of GPI anchor in ER membrane (GO:0016254)2.40786291
134regulation of action potential (GO:0098900)2.40397882
135pigment metabolic process (GO:0042440)2.37667399
136negative regulation of hormone metabolic process (GO:0032351)2.36448899
137negative regulation of hormone biosynthetic process (GO:0032353)2.36448899
138eye morphogenesis (GO:0048592)2.35971804
139short-chain fatty acid metabolic process (GO:0046459)2.31981694
140somatic stem cell division (GO:0048103)2.30093614
141skeletal muscle adaptation (GO:0043501)2.28936135
142organ formation (GO:0048645)2.27702129
143G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.27041122
144branch elongation of an epithelium (GO:0060602)2.26751426
145negative regulation of Rho protein signal transduction (GO:0035024)2.23504000
146regulation of systemic arterial blood pressure (GO:0003073)2.16723327
147myelination in peripheral nervous system (GO:0022011)2.15272373
148peripheral nervous system axon ensheathment (GO:0032292)2.15272373
149* protein-chromophore linkage (GO:0018298)2.13369388
150leukotriene biosynthetic process (GO:0019370)2.11109554
151axis elongation (GO:0003401)2.07733817
152vitamin metabolic process (GO:0006766)2.06204579
153phosphatidylinositol acyl-chain remodeling (GO:0036149)2.05379641
154phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.04826156
155mitochondrion localization (GO:0051646)2.04275344
156regulation of glucocorticoid metabolic process (GO:0031943)2.03593690
157negative regulation of actin filament bundle assembly (GO:0032232)2.03137279
158collagen metabolic process (GO:0032963)2.02394555
159collagen catabolic process (GO:0030574)2.01267639
160regulation of neuroblast proliferation (GO:1902692)2.00255522
161melanin biosynthetic process (GO:0042438)14.9323343
162retinal metabolic process (GO:0042574)13.9205199
163melanin metabolic process (GO:0006582)13.5327676
164secondary metabolite biosynthetic process (GO:0044550)12.6091895
165retinol metabolic process (GO:0042572)10.7943951
166cellular response to electrical stimulus (GO:0071257)10.4265322
167multicellular organismal macromolecule metabolic process (GO:0044259)1.93586073
168rhodopsin mediated signaling pathway (GO:0016056)1.91231906
169negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)1.87188645
170endothelial cell morphogenesis (GO:0001886)1.85970693
171multicellular organismal catabolic process (GO:0044243)1.85080078
172tonic smooth muscle contraction (GO:0014820)1.84605199
173L-ascorbic acid metabolic process (GO:0019852)1.83243451
174phosphatidylserine acyl-chain remodeling (GO:0036150)1.82502056
175multicellular organismal metabolic process (GO:0044236)1.82264417
176regulation of rhodopsin mediated signaling pathway (GO:0022400)1.81889910
177phenol-containing compound metabolic process (GO:0018958)1.81326408
178positive regulation of cell junction assembly (GO:1901890)1.77877440
179positive regulation of focal adhesion assembly (GO:0051894)1.77877440
180neuronal ion channel clustering (GO:0045161)1.76213044
181pyruvate metabolic process (GO:0006090)1.74103955
182monocarboxylic acid transport (GO:0015718)1.73543001
183hormone metabolic process (GO:0042445)1.72540561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.05973176
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.34775292
3EZH2_22144423_ChIP-Seq_EOC_Human3.31627379
4VDR_22108803_ChIP-Seq_LS180_Human3.23966173
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.78868583
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72106761
7ZNF274_21170338_ChIP-Seq_K562_Hela2.69450568
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63413339
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53279925
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.51002636
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29684939
12IGF1R_20145208_ChIP-Seq_DFB_Human2.25309099
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.23484758
14BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.20433097
15P300_19829295_ChIP-Seq_ESCs_Human2.16114942
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06583964
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.04330885
18ERG_21242973_ChIP-ChIP_JURKAT_Human1.99426401
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.97987377
20FUS_26573619_Chip-Seq_HEK293_Human1.97821571
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96492998
22BCAT_22108803_ChIP-Seq_LS180_Human1.91994402
23RXR_22158963_ChIP-Seq_LIVER_Mouse1.91165773
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88934700
25EWS_26573619_Chip-Seq_HEK293_Human1.87536271
26STAT3_23295773_ChIP-Seq_U87_Human1.85361084
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.78183980
28ER_23166858_ChIP-Seq_MCF-7_Human1.76954394
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74133438
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71449199
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.68399724
32TCF4_23295773_ChIP-Seq_U87_Human1.66055244
33LXR_22158963_ChIP-Seq_LIVER_Mouse1.66048897
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.63184689
35CLOCK_20551151_ChIP-Seq_293T_Human1.60792852
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60467050
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60135225
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57393646
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57393646
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57187846
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56425750
42TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.56180012
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55670229
44TCF4_22108803_ChIP-Seq_LS180_Human1.54141281
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54069535
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.52933811
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52538833
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51666032
49CBP_20019798_ChIP-Seq_JUKART_Human1.51554755
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51554755
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.50389398
52CJUN_26792858_Chip-Seq_BT549_Human1.49593290
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48887259
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.47942500
55CDX2_22108803_ChIP-Seq_LS180_Human1.47330686
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45927413
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44767507
58RUNX2_22187159_ChIP-Seq_PCA_Human1.44225062
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43244469
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42481089
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40197403
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38281615
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37756817
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35734875
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34400873
66AR_21572438_ChIP-Seq_LNCaP_Human1.33523675
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33102140
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32788034
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.32501019
70EGR1_19032775_ChIP-ChIP_M12_Human1.32335438
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.31493560
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30726659
73NANOG_19829295_ChIP-Seq_ESCs_Human1.30593707
74SOX2_19829295_ChIP-Seq_ESCs_Human1.30593707
75* REST_21632747_ChIP-Seq_MESCs_Mouse1.30166371
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30144757
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30144757
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.29709068
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29373939
80TP53_22573176_ChIP-Seq_HFKS_Human1.27932493
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27810137
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.27793080
83TP53_16413492_ChIP-PET_HCT116_Human1.25915715
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25643718
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.24650043
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.24351993
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24348982
88EED_16625203_ChIP-ChIP_MESCs_Mouse1.24068101
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23836339
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.23689254
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23444818
92AR_25329375_ChIP-Seq_VCAP_Human1.23346795
93SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23214569
94KDM2B_26808549_Chip-Seq_REH_Human1.23018669
95* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22272254
96* PRDM14_20953172_ChIP-Seq_ESCs_Human1.21605266
97CRX_20693478_ChIP-Seq_RETINA_Mouse1.21563410
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21213059
99TP53_18474530_ChIP-ChIP_U2OS_Human1.20620195
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20529389
101DROSHA_22980978_ChIP-Seq_HELA_Human1.20478594
102RNF2_27304074_Chip-Seq_ESCs_Mouse1.18405170
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17891537
104TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17426144
105AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17136851
106GBX2_23144817_ChIP-Seq_PC3_Human1.17056361
107EZH2_27294783_Chip-Seq_ESCs_Mouse1.16974571
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16868714
109JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16622427
110P53_22387025_ChIP-Seq_ESCs_Mouse1.16401098
111SMAD4_21799915_ChIP-Seq_A2780_Human1.16156476
112SOX2_21211035_ChIP-Seq_LN229_Gbm1.15869208
113ZNF263_19887448_ChIP-Seq_K562_Human1.15775217
114JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14882626
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14812624
116EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14402810
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14017891
118OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13945023
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13944021
120WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12890572
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12756812
122TCF4_18268006_ChIP-ChIP_LS174T_Human1.12478872
123NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10818723
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10818723
125RNF2_27304074_Chip-Seq_NSC_Mouse1.10303302
126TAF15_26573619_Chip-Seq_HEK293_Human1.09221586
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09000050
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08745623
129NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08073188
130PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07771914
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07713967
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06987905
133E2F1_18555785_Chip-Seq_ESCs_Mouse1.06855269
134NCOR_22424771_ChIP-Seq_293T_Human1.06785817
135AHR_22903824_ChIP-Seq_MCF-7_Human1.06441104
136FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05885902
137NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05577320
138SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.05510377
139NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04501095
140* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04114731
141SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03899116
142FOXO3_23340844_ChIP-Seq_DLD1_Human1.03501592
143P300_18555785_Chip-Seq_ESCs_Mouse1.02445238
144CMYC_18555785_Chip-Seq_ESCs_Mouse1.02381412
145ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02063284
146TAL1_26923725_Chip-Seq_HPCs_Mouse1.00868708
147* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99828708
148CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99529972
149FOXA2_19822575_ChIP-Seq_HepG2_Human0.99175966
150RXR_22108803_ChIP-Seq_LS180_Human0.98941531
151JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98770739
152SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98683737
153TBX20_22328084_ChIP-Seq_HEART_Mouse0.97855785
154TBX20_22080862_ChIP-Seq_HEART_Mouse0.97855785
155KDM2B_26808549_Chip-Seq_JURKAT_Human0.96606263
156DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96559924
157ESR1_21235772_ChIP-Seq_MCF-7_Human0.96502051
158ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96146048
159SMAD4_21741376_ChIP-Seq_HESCs_Human0.96077317
160* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95416038
161KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95041472
162TBL1_22424771_ChIP-Seq_293T_Human0.95005586
163PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94761585
164CTCF_27219007_Chip-Seq_Bcells_Human0.93090651
165ARNT_22903824_ChIP-Seq_MCF-7_Human0.92600384
166SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91469603
167PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91143741
168CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90711503
169SOX2_20726797_ChIP-Seq_SW620_Human0.90588003
170RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89564545
171GATA2_21666600_ChIP-Seq_HMVEC_Human0.89365716
172SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89100441
173KDM2B_26808549_Chip-Seq_K562_Human0.88418394
174EZH2_27304074_Chip-Seq_ESCs_Mouse0.87775178
175CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87408109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation5.08329238
2MP0005257_abnormal_intraocular_pressure4.95511119
3MP0003136_yellow_coat_color4.03891419
4MP0004019_abnormal_vitamin_homeostasis3.72549635
5MP0005171_absent_coat_pigmentation3.63678743
6MP0001324_abnormal_eye_pigmentation3.18520093
7MP0005646_abnormal_pituitary_gland3.17455846
8MP0002736_abnormal_nociception_after2.96158349
9MP0001986_abnormal_taste_sensitivity2.95801834
10MP0001968_abnormal_touch/_nociception2.84323878
11* MP0005551_abnormal_eye_electrophysiolog2.73083821
12MP0002090_abnormal_vision2.72683097
13* MP0005253_abnormal_eye_physiology2.39889159
14MP0004147_increased_porphyrin_level2.38831207
15MP0005670_abnormal_white_adipose2.34403042
16MP0005408_hypopigmentation2.28818423
17MP0000371_diluted_coat_color2.27636496
18MP0005423_abnormal_somatic_nervous2.19101876
19MP0005409_darkened_coat_color2.03946875
20MP0003011_delayed_dark_adaptation15.9105995
21MP0003880_abnormal_central_pattern1.92386082
22MP0001486_abnormal_startle_reflex1.83492882
23MP0009046_muscle_twitch1.70948591
24MP0001501_abnormal_sleep_pattern1.69654277
25MP0003195_calcinosis1.68593404
26MP0000015_abnormal_ear_pigmentation1.66983129
27MP0009745_abnormal_behavioral_response1.64640040
28MP0003183_abnormal_peptide_metabolism1.63983541
29MP0002735_abnormal_chemical_nociception1.58660298
30MP0008995_early_reproductive_senescence1.57977394
31MP0006276_abnormal_autonomic_nervous1.55142861
32MP0002272_abnormal_nervous_system1.53848798
33MP0008872_abnormal_physiological_respon1.52056708
34MP0001764_abnormal_homeostasis1.45098688
35* MP0005391_vision/eye_phenotype1.42182906
36MP0005075_abnormal_melanosome_morpholog1.41879240
37MP0008438_abnormal_cutaneous_collagen1.40253945
38MP0000631_abnormal_neuroendocrine_gland1.36158150
39MP0002092_abnormal_eye_morphology1.34732716
40MP0002075_abnormal_coat/hair_pigmentati1.34711905
41MP0004381_abnormal_hair_follicle1.32851739
42MP0000516_abnormal_urinary_system1.31873325
43MP0005367_renal/urinary_system_phenotyp1.31873325
44MP0001485_abnormal_pinna_reflex1.30417622
45MP0002876_abnormal_thyroid_physiology1.24892612
46MP0001984_abnormal_olfaction1.22259237
47MP0002064_seizures1.20212039
48MP0003646_muscle_fatigue1.20062155
49MP0002572_abnormal_emotion/affect_behav1.18019178
50MP0005503_abnormal_tendon_morphology1.16469244
51MP0005197_abnormal_uvea_morphology1.15926257
52MP0005195_abnormal_posterior_eye1.15208920
53MP0003635_abnormal_synaptic_transmissio1.14340409
54MP0002095_abnormal_skin_pigmentation1.14129455
55MP0005275_abnormal_skin_tensile1.11386530
56MP0002138_abnormal_hepatobiliary_system1.10385932
57MP0001970_abnormal_pain_threshold1.08204800
58MP0001186_pigmentation_phenotype1.07473822
59MP0002063_abnormal_learning/memory/cond1.07094910
60MP0002877_abnormal_melanocyte_morpholog1.07030183
61MP0002733_abnormal_thermal_nociception1.04899797
62MP0000026_abnormal_inner_ear1.04384242
63MP0004133_heterotaxia1.03227876
64MP0004885_abnormal_endolymph1.02262513
65MP0001963_abnormal_hearing_physiology1.01804690
66MP0005174_abnormal_tail_pigmentation1.01087366
67MP0004142_abnormal_muscle_tone0.99641787
68MP0002067_abnormal_sensory_capabilities0.98990209
69MP0002234_abnormal_pharynx_morphology0.98054051
70MP0003633_abnormal_nervous_system0.96540015
71MP0003878_abnormal_ear_physiology0.91777185
72MP0005377_hearing/vestibular/ear_phenot0.91777185
73MP0008877_abnormal_DNA_methylation0.91080102
74MP0004272_abnormal_basement_membrane0.87114972
75MP0002089_abnormal_postnatal_growth/wei0.85880390
76MP0004742_abnormal_vestibular_system0.85401415
77MP0005410_abnormal_fertilization0.84148551
78MP0001661_extended_life_span0.83330860
79MP0002557_abnormal_social/conspecific_i0.81558867
80MP0002734_abnormal_mechanical_nocicepti0.80710178
81MP0005193_abnormal_anterior_eye0.80472926
82MP0003705_abnormal_hypodermis_morpholog0.77820542
83MP0005332_abnormal_amino_acid0.77199528
84MP0003045_fibrosis0.76178475
85MP0005386_behavior/neurological_phenoty0.75415367
86MP0004924_abnormal_behavior0.75415367
87MP0001502_abnormal_circadian_rhythm0.75010096
88MP0000230_abnormal_systemic_arterial0.74655314
89MP0010386_abnormal_urinary_bladder0.74177848
90MP0006292_abnormal_olfactory_placode0.72943050
91MP0001756_abnormal_urination0.71395017
92MP0000427_abnormal_hair_cycle0.71312997
93MP0002184_abnormal_innervation0.71192494
94MP0004043_abnormal_pH_regulation0.70673876
95MP0005647_abnormal_sex_gland0.69303199
96MP0003698_abnormal_male_reproductive0.68181495
97MP0000647_abnormal_sebaceous_gland0.65893467
98MP0000778_abnormal_nervous_system0.65391962
99MP0006054_spinal_hemorrhage0.65004405
100MP0005645_abnormal_hypothalamus_physiol0.64909104
101MP0003724_increased_susceptibility_to0.63539617
102MP0003879_abnormal_hair_cell0.62598069
103MP0010234_abnormal_vibrissa_follicle0.61903332
104MP0003631_nervous_system_phenotype0.61605358
105MP0010329_abnormal_lipoprotein_level0.58382117
106MP0009384_cardiac_valve_regurgitation0.53094010
107MP0004084_abnormal_cardiac_muscle0.52802003
108MP0002229_neurodegeneration0.52307156
109MP0010368_abnormal_lymphatic_system0.50639707
110MP0004036_abnormal_muscle_relaxation0.49977475
111MP0002638_abnormal_pupillary_reflex0.49880100
112MP0002102_abnormal_ear_morphology0.48226532
113MP0002139_abnormal_hepatobiliary_system0.47753951
114MP0005248_abnormal_Harderian_gland0.46083304
115MP0004130_abnormal_muscle_cell0.42481981
116MP0002752_abnormal_somatic_nervous0.41657904
117MP0002938_white_spotting0.40197311
118MP0005360_urolithiasis0.35992240
119MP0005167_abnormal_blood-brain_barrier0.34906635
120MP0000751_myopathy0.31625932
121MP0002108_abnormal_muscle_morphology0.31022241
122MP0008875_abnormal_xenobiotic_pharmacok0.30310898
123MP0000013_abnormal_adipose_tissue0.28529013
124MP0000367_abnormal_coat/_hair0.26891694
125MP0003453_abnormal_keratinocyte_physiol0.26573416
126MP0000428_abnormal_craniofacial_morphol0.26486948
127MP0005085_abnormal_gallbladder_physiolo0.26169932
128MP0004270_analgesia0.25864114
129MP0009780_abnormal_chondrocyte_physiolo0.25854148
130MP0010030_abnormal_orbit_morphology0.24569774
131MP0002177_abnormal_outer_ear0.24515689
132MP0003690_abnormal_glial_cell0.24268683
133MP0002233_abnormal_nose_morphology0.24088555
134MP0009840_abnormal_foam_cell0.24080110
135MP0002882_abnormal_neuron_morphology0.23607392
136MP0006072_abnormal_retinal_apoptosis0.23579120
137MP0005623_abnormal_meninges_morphology0.23491801
138MP0000747_muscle_weakness0.23054371
139MP0003941_abnormal_skin_development0.22994178
140MP0003300_gastrointestinal_ulcer0.22970730
141MP0003938_abnormal_ear_development0.22615044
142MP0005620_abnormal_muscle_contractility0.21695562
143MP0004859_abnormal_synaptic_plasticity0.19893034
144MP0002332_abnormal_exercise_endurance0.19762845
145MP0000569_abnormal_digit_pigmentation0.18798879
146MP0003279_aneurysm0.17629742
147MP0008775_abnormal_heart_ventricle0.17502014
148MP0003329_amyloid_beta_deposits0.16130047
149MP0005365_abnormal_bile_salt0.15977416
150MP0004145_abnormal_muscle_electrophysio0.15818185
151MP0003806_abnormal_nucleotide_metabolis0.15749580
152MP0005508_abnormal_skeleton_morphology0.15395098
153MP0003075_altered_response_to0.15066264
154MP0003252_abnormal_bile_duct0.13749893
155MP0001958_emphysema0.13716152
156MP0001879_abnormal_lymphatic_vessel0.13686308
157MP0003115_abnormal_respiratory_system0.13273847
158MP0002837_dystrophic_cardiac_calcinosis0.12750571
159MP0000467_abnormal_esophagus_morphology0.12636160
160MP0000749_muscle_degeneration0.12413553
161MP0010678_abnormal_skin_adnexa0.12333245
162MP0004215_abnormal_myocardial_fiber0.12044797
163MP0003566_abnormal_cell_adhesion0.11834549
164MP0001177_atelectasis0.11512601
165MP0005187_abnormal_penis_morphology0.11464017
166MP0002282_abnormal_trachea_morphology0.10796832
167MP0002118_abnormal_lipid_homeostasis0.10476651

Predicted human phenotypes

RankGene SetZ-score
1Increased corneal curvature (HP:0100692)8.46025954
2Keratoconus (HP:0000563)8.46025954
3Aplasia/Hypoplasia of the fovea (HP:0008060)8.20767965
4Hypoplasia of the fovea (HP:0007750)8.20767965
5* Attenuation of retinal blood vessels (HP:0007843)7.57950007
6* Hypopigmentation of the fundus (HP:0007894)6.93760856
7Choroideremia (HP:0001139)6.60608120
8Aplasia/Hypoplasia of the macula (HP:0008059)6.44420454
9Bony spicule pigmentary retinopathy (HP:0007737)6.13156920
10Aplasia/Hypoplasia affecting the retina (HP:0008061)6.04440806
11Blue irides (HP:0000635)5.86753074
12Abnormal rod and cone electroretinograms (HP:0008323)5.64943817
13Abolished electroretinogram (ERG) (HP:0000550)5.51859692
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.19711836
15Abnormality of alanine metabolism (HP:0010916)5.19711836
16Hyperalaninemia (HP:0003348)5.19711836
17Scotoma (HP:0000575)4.85283922
18Nonprogressive disorder (HP:0003680)4.84831660
19Congenital sensorineural hearing impairment (HP:0008527)4.84404393
20Action tremor (HP:0002345)4.31808626
21Ocular albinism (HP:0001107)4.20499855
22Iris hypopigmentation (HP:0007730)3.75284935
23Congenital stationary night blindness (HP:0007642)3.70693184
24Pendular nystagmus (HP:0012043)3.66624379
25Pancreatic cysts (HP:0001737)3.46710272
26Corneal dystrophy (HP:0001131)3.40883429
27True hermaphroditism (HP:0010459)3.39782838
28Pancreatic fibrosis (HP:0100732)3.23208082
29Hyperventilation (HP:0002883)3.17925557
30* Type II diabetes mellitus (HP:0005978)3.12200523
31Chronic hepatic failure (HP:0100626)3.12020242
32Progressive cerebellar ataxia (HP:0002073)2.93975974
33Macular degeneration (HP:0000608)2.92927212
34Abnormality of midbrain morphology (HP:0002418)2.91275602
35Molar tooth sign on MRI (HP:0002419)2.91275602
36Gaze-evoked nystagmus (HP:0000640)2.85132947
37* Photophobia (HP:0000613)2.84114901
38* Constricted visual fields (HP:0001133)2.81251134
39Intestinal atresia (HP:0011100)2.70920440
40Generalized hypopigmentation of hair (HP:0011358)2.63682240
41Thyroid-stimulating hormone excess (HP:0002925)2.58494210
42Nephronophthisis (HP:0000090)2.58233720
43Freckling (HP:0001480)2.54192614
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.53691690
45Stereotypic behavior (HP:0000733)2.49334253
46Central scotoma (HP:0000603)2.48382527
47Absent speech (HP:0001344)2.46948192
48Pigmentary retinal degeneration (HP:0001146)2.34271479
49Abnormality of the renal cortex (HP:0011035)2.34248385
50Febrile seizures (HP:0002373)2.32319036
51Abnormality of the renal medulla (HP:0100957)2.31904134
52Ulnar claw (HP:0001178)2.29968597
53Medial flaring of the eyebrow (HP:0010747)2.29166820
54Type 1 muscle fiber predominance (HP:0003803)2.28968242
55Genetic anticipation (HP:0003743)2.27152246
56Protrusio acetabuli (HP:0003179)2.25833369
57Chorioretinal atrophy (HP:0000533)2.23741266
58Focal seizures (HP:0007359)2.22596982
59Broad-based gait (HP:0002136)2.22191661
60Exercise-induced muscle cramps (HP:0003710)2.21807278
61Severe visual impairment (HP:0001141)2.21759116
62Focal motor seizures (HP:0011153)2.21470679
63Progressive inability to walk (HP:0002505)2.21303501
64Cystic liver disease (HP:0006706)2.20276201
65Inability to walk (HP:0002540)2.15371496
66Spontaneous hematomas (HP:0007420)2.14117555
67Abnormality of the labia minora (HP:0012880)2.09636666
68Abnormality of serum amino acid levels (HP:0003112)2.06863982
69Blindness (HP:0000618)2.05871899
70Hemiparesis (HP:0001269)2.04964868
71Hyperglycinemia (HP:0002154)2.03331729
72Dyschromatopsia (HP:0007641)2.01095938
73Anencephaly (HP:0002323)2.00486184
74Type II lissencephaly (HP:0007260)2.00181473
75* Decreased electroretinogram (ERG) amplitude (HP:0000654)13.8148906
76Abnormality of the fovea (HP:0000493)11.6583012
77Decreased central vision (HP:0007663)10.7113981
78Atonic seizures (HP:0010819)1.98242131
79Nephrogenic diabetes insipidus (HP:0009806)1.97436181
80Dialeptic seizures (HP:0011146)1.96033522
81Gait imbalance (HP:0002141)1.93612088
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.88053337
83Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.87682255
84Round ear (HP:0100830)1.87449131
85Renal cortical cysts (HP:0000803)1.87240061
86Abnormal drinking behavior (HP:0030082)1.86375889
87Polydipsia (HP:0001959)1.86375889
88Esophageal varix (HP:0002040)1.85549115
89Epidermoid cyst (HP:0200040)1.84851915
90Poor speech (HP:0002465)1.83825606
91Postural tremor (HP:0002174)1.83337273
92Congenital primary aphakia (HP:0007707)1.83094891
93Generalized hypopigmentation (HP:0007513)1.80790749
94Birth length less than 3rd percentile (HP:0003561)1.80152103
95Abnormality of macular pigmentation (HP:0008002)1.79519313
96Hyperglycinuria (HP:0003108)1.79017739
97White forelock (HP:0002211)1.78878247
98Genital tract atresia (HP:0001827)1.76990162
99Short tibia (HP:0005736)1.72562352
100Abnormality of the renal collecting system (HP:0004742)1.69926013
101Bile duct proliferation (HP:0001408)1.67951429
102Abnormal biliary tract physiology (HP:0012439)1.67951429
103Absence seizures (HP:0002121)1.67435449
104Tubular atrophy (HP:0000092)1.65525633
105Abnormal respiratory motile cilium morphology (HP:0005938)1.65092222
106Abnormal respiratory epithelium morphology (HP:0012253)1.65092222
107Aortic dissection (HP:0002647)1.64711961
108Postaxial foot polydactyly (HP:0001830)1.64186605
109Hypomagnesemia (HP:0002917)1.63629640
110Abnormality of serine family amino acid metabolism (HP:0010894)1.63459890
111Abnormality of glycine metabolism (HP:0010895)1.63459890
112Distal arthrogryposis (HP:0005684)1.63380011
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.63364788
114Nemaline bodies (HP:0003798)1.62624972
115Vaginal atresia (HP:0000148)1.62488722
116Tubulointerstitial nephritis (HP:0001970)1.61486412
117Sclerocornea (HP:0000647)1.59895029
118Cerebral aneurysm (HP:0004944)1.59084928
119Broad metatarsal (HP:0001783)1.58859137
120Hypoplasia of the iris (HP:0007676)1.57621485
121Muscle fiber inclusion bodies (HP:0100299)1.57505995
122Hypermetropia (HP:0000540)1.55490884
123Aortic aneurysm (HP:0004942)1.53414083
124Patchy hypopigmentation of hair (HP:0011365)1.50436872
125Flat cornea (HP:0007720)1.50436676
126Right ventricular cardiomyopathy (HP:0011663)1.48564774
127Subacute progressive viral hepatitis (HP:0006572)1.46072221
128* Wide nasal bridge (HP:0000431)1.45322355
129Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.41987366
130Cone-rod dystrophy (HP:0000548)1.41572294
131Annular pancreas (HP:0001734)1.38838555
132Exercise-induced myalgia (HP:0003738)1.36615015
133Deep venous thrombosis (HP:0002625)1.35625643
134Premature rupture of membranes (HP:0001788)1.34275375
135Heterochromia iridis (HP:0001100)1.34085257
136Mitral valve prolapse (HP:0001634)1.32799070
137Calcaneovalgus deformity (HP:0001848)1.32777456
138Xanthomatosis (HP:0000991)1.32154243
139Hypoventilation (HP:0002791)1.29668118
140Arterial tortuosity (HP:0005116)1.29482105
141Slender build (HP:0001533)1.28020119
142Hypoalphalipoproteinemia (HP:0003233)1.27846323
143Increased connective tissue (HP:0009025)1.26989583
144Optic disc pallor (HP:0000543)1.26762046
145Hyperlipoproteinemia (HP:0010980)1.26048208
146Increased variability in muscle fiber diameter (HP:0003557)1.25634560
147Vascular tortuosity (HP:0004948)1.25024630
148Posterior subcapsular cataract (HP:0007787)1.24290561
149Retinitis pigmentosa (HP:0000510)1.23992864
150Subcapsular cataract (HP:0000523)1.18821440
151Pallor (HP:0000980)1.18332749
152Striae distensae (HP:0001065)1.16164093
153Absent rod-and cone-mediated responses on ERG (HP:0007688)1.14740122
154Deformed tarsal bones (HP:0008119)1.14572734
155Shallow orbits (HP:0000586)1.13563986
156Absent phalangeal crease (HP:0006109)1.13442855
157Hematochezia (HP:0002573)1.13358304
158Retinal atrophy (HP:0001105)1.12303512
159Abnormality of skeletal muscle fiber size (HP:0012084)1.11920769
160Frequent falls (HP:0002359)1.10461265
161Melanoma (HP:0002861)1.08985443
162Ulnar deviation of the wrist (HP:0003049)1.08252505
163EMG: myopathic abnormalities (HP:0003458)1.07144872
164Abnormality of vision evoked potentials (HP:0000649)1.05464130
165Pancreatic islet-cell hyperplasia (HP:0004510)1.04991025
166Vitreoretinal degeneration (HP:0000655)1.04215180
167Ankle contracture (HP:0006466)1.03659352
168Hypoglycemic coma (HP:0001325)1.02570082
169Hyporeflexia of lower limbs (HP:0002600)1.00130031
170Peritonitis (HP:0002586)0.99296444
171Progressive visual loss (HP:0000529)0.97107016
172Abnormal pancreas size (HP:0012094)0.96272598
173Mitral stenosis (HP:0001718)0.96176080
174Cardiovascular calcification (HP:0011915)0.95245023

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.61567166
2MST1R4.40864179
3ACVR1B3.35502581
4PDK23.23404370
5ADRBK22.83202062
6PKN22.77120984
7TTN2.58588435
8TIE12.51844852
9LATS12.45673064
10DDR22.42985283
11FGFR22.32873900
12BMPR1B2.31166454
13WNK32.30607501
14TRIB32.25734298
15FRK2.20026207
16TGFBR22.16289461
17MET2.13137657
18CASK2.13101125
19MAPK131.88727174
20MAP4K21.88273717
21NUAK11.86284766
22RIPK11.77279332
23PTK61.76456065
24NTRK21.70250461
25MAP3K41.62047621
26SCYL21.59286703
27SIK11.55274998
28GRK11.53249281
29SGK21.50679278
30PDGFRA1.48347169
31LRRK21.44407469
32BMX1.44218648
33NTRK11.36583871
34PIK3CG1.30627999
35SGK2231.29915112
36SGK4941.29915112
37MAP3K21.28864529
38OXSR11.28352644
39MAP3K31.25617927
40KDR1.25038613
41MARK31.24565089
42CCNB11.17066118
43PRKCH1.16679339
44STK38L1.16443868
45TAOK31.15538946
46PIK3CA1.14823538
47PDK31.10995425
48PDK41.10995425
49MYLK1.09612512
50BCR1.07597284
51MAPK121.05289446
52MKNK21.05070389
53ZAK1.04586779
54FER1.02125816
55PHKG11.02059747
56PHKG21.02059747
57STK391.01759551
58WNK41.01055170
59MAP2K70.99218446
60GSK3A0.98770823
61HIPK20.96094960
62MINK10.95598311
63PAK30.94675649
64MAP3K90.94654422
65PRKCG0.93672573
66EPHA40.87928620
67RET0.87373341
68JAK30.87146696
69CAMK2A0.86109830
70TRIM280.85893046
71TNIK0.83244403
72KSR20.82518193
73TGFBR10.81972264
74TXK0.80780184
75FGR0.80331925
76PDK10.80120270
77PLK20.79401338
78PINK10.78554676
79FLT30.78500797
80PDPK10.78250701
81EPHB10.77794410
82TNK20.77498260
83ROCK20.74727639
84CDK90.74627879
85PAK60.73995470
86PAK20.72837877
87PDGFRB0.72274076
88MAPK70.71755710
89CSNK1G10.71220899
90MAP2K30.70845889
91SGK30.70323603
92IRAK10.70222769
93DYRK20.68473248
94CSNK1G20.68255586
95MKNK10.67278406
96ERBB20.67049531
97TEC0.66705202
98PKN10.66623215
99DMPK0.65656594
100NTRK30.64642036
101CAMKK10.64618276
102LATS20.64264875
103MAP3K70.64219658
104MAP2K40.64079451
105CAMK10.63811419
106JAK10.62341975
107AKT30.61767032
108PRKD10.61635274
109CSNK1A10.61528938
110MAPKAPK50.61519995
111PAK40.61286891
112STK380.59638841
113STK30.57837770
114UHMK10.56817728
115ERBB30.56787879
116KIT0.56188068
117CDK190.55975497
118ADRBK10.54973051
119CAMKK20.54591214
120FGFR10.52164236
121PRKACA0.49962639
122NEK10.49151026
123DAPK20.48812393
124NEK60.48754652
125RPS6KB20.48684915
126JAK20.48201589
127CSNK1A1L0.47480196
128INSRR0.46535169
129GRK50.46106005
130PRKCA0.45776807
131CAMK2D0.45404646
132CAMK1D0.44564504
133PRKD30.44559290
134CDK50.44250129
135EIF2AK30.44142057
136SGK10.43736709
137SRC0.43243503
138EPHB20.42938075
139PRKAA20.42885105
140PRKCQ0.42716964
141FYN0.41792121
142ERBB40.41353084
143EGFR0.41094126
144BRD40.40724319
145CAMK2B0.40658089
146PRKCE0.40291170
147TAF10.40268802
148INSR0.40093671
149CSNK1D0.39511923
150MARK10.38900423
151IGF1R0.38629856
152PRKG10.38454365
153ERN10.38082034
154ITK0.37827068
155STK110.37586317
156DYRK1A0.37210983
157LMTK20.36217840
158ROCK10.36142192
159BCKDK0.35793929
160TYRO30.35144324
161MAPK40.35095855
162CAMK40.34354440
163PTK2B0.34016092
164CSNK1G30.33570218
165AKT20.33245913
166PRKCZ0.32951312
167MAP2K10.32610213
168PRKAA10.31855714

Predicted pathways (KEGG)

RankGene SetZ-score
1Retinol metabolism_Homo sapiens_hsa008307.17594532
2Phototransduction_Homo sapiens_hsa047444.74917506
3Tyrosine metabolism_Homo sapiens_hsa003504.70310040
4Nitrogen metabolism_Homo sapiens_hsa009103.28990417
5Vitamin digestion and absorption_Homo sapiens_hsa049773.11121135
6Nicotine addiction_Homo sapiens_hsa050333.00512314
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.87124730
8Morphine addiction_Homo sapiens_hsa050322.49998685
9Phenylalanine metabolism_Homo sapiens_hsa003602.39993619
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10257200
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.97545747
12Bile secretion_Homo sapiens_hsa049761.82013793
13Taste transduction_Homo sapiens_hsa047421.81987709
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80450517
15One carbon pool by folate_Homo sapiens_hsa006701.77748842
16Histidine metabolism_Homo sapiens_hsa003401.76223762
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.75443993
18Collecting duct acid secretion_Homo sapiens_hsa049661.73619326
19Melanogenesis_Homo sapiens_hsa049161.73129591
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69071894
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55448813
22Serotonergic synapse_Homo sapiens_hsa047261.55313775
23Chemical carcinogenesis_Homo sapiens_hsa052041.54198528
24Selenocompound metabolism_Homo sapiens_hsa004501.51221445
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50431647
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46019438
27Linoleic acid metabolism_Homo sapiens_hsa005911.41873960
28Olfactory transduction_Homo sapiens_hsa047401.38026649
29beta-Alanine metabolism_Homo sapiens_hsa004101.31806976
30Regulation of autophagy_Homo sapiens_hsa041401.26488528
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.26338326
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.25424219
33Arginine biosynthesis_Homo sapiens_hsa002201.22298739
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18477579
35Tight junction_Homo sapiens_hsa045301.16861664
36Fat digestion and absorption_Homo sapiens_hsa049751.16289959
37Gastric acid secretion_Homo sapiens_hsa049711.11028187
38Basal transcription factors_Homo sapiens_hsa030221.08918896
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08761284
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06416374
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.03930488
42Salivary secretion_Homo sapiens_hsa049701.01942083
43Fatty acid degradation_Homo sapiens_hsa000711.00719234
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98682362
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97998319
46Renin secretion_Homo sapiens_hsa049240.97648735
47ECM-receptor interaction_Homo sapiens_hsa045120.97461772
48Peroxisome_Homo sapiens_hsa041460.95715257
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.93911381
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.91534268
51Insulin secretion_Homo sapiens_hsa049110.90547149
52Glycerolipid metabolism_Homo sapiens_hsa005610.90491548
53Caffeine metabolism_Homo sapiens_hsa002320.82986081
54Fanconi anemia pathway_Homo sapiens_hsa034600.82320742
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81743363
56Sulfur relay system_Homo sapiens_hsa041220.81576262
57Homologous recombination_Homo sapiens_hsa034400.80511030
58Circadian entrainment_Homo sapiens_hsa047130.79647850
59Glioma_Homo sapiens_hsa052140.79221430
60Butanoate metabolism_Homo sapiens_hsa006500.77665440
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76740601
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74970528
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74509918
64Long-term potentiation_Homo sapiens_hsa047200.73579340
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73538155
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73402479
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72881490
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71811295
69Ether lipid metabolism_Homo sapiens_hsa005650.70671376
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.70271591
71Focal adhesion_Homo sapiens_hsa045100.70160439
72Dilated cardiomyopathy_Homo sapiens_hsa054140.69943854
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69828650
74Sphingolipid metabolism_Homo sapiens_hsa006000.69013792
75Complement and coagulation cascades_Homo sapiens_hsa046100.66462767
76Fatty acid metabolism_Homo sapiens_hsa012120.65007375
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61191375
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.60472953
79Arginine and proline metabolism_Homo sapiens_hsa003300.59815839
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59325843
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59000716
82Arachidonic acid metabolism_Homo sapiens_hsa005900.58420471
83Amphetamine addiction_Homo sapiens_hsa050310.58416997
84GABAergic synapse_Homo sapiens_hsa047270.57618275
85Glucagon signaling pathway_Homo sapiens_hsa049220.57149659
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55897430
87Long-term depression_Homo sapiens_hsa047300.55517040
88Circadian rhythm_Homo sapiens_hsa047100.55503076
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54871001
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53688593
91Protein digestion and absorption_Homo sapiens_hsa049740.53680436
92Pancreatic secretion_Homo sapiens_hsa049720.53654220
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53453268
94Amoebiasis_Homo sapiens_hsa051460.52468742
95Proteoglycans in cancer_Homo sapiens_hsa052050.52050423
96RNA degradation_Homo sapiens_hsa030180.51579322
97Ovarian steroidogenesis_Homo sapiens_hsa049130.51085896
98Oxytocin signaling pathway_Homo sapiens_hsa049210.49859363
99Sulfur metabolism_Homo sapiens_hsa009200.49716643
100Estrogen signaling pathway_Homo sapiens_hsa049150.49097343
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48474186
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46903756
103Metabolic pathways_Homo sapiens_hsa011000.46708260
104Propanoate metabolism_Homo sapiens_hsa006400.46264960
105Dopaminergic synapse_Homo sapiens_hsa047280.45355263
106PPAR signaling pathway_Homo sapiens_hsa033200.45039467
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44097825
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43265402
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43229858
110GnRH signaling pathway_Homo sapiens_hsa049120.42608132
111Tryptophan metabolism_Homo sapiens_hsa003800.42110654
112Cocaine addiction_Homo sapiens_hsa050300.42041258
113Synaptic vesicle cycle_Homo sapiens_hsa047210.41351147
114Renal cell carcinoma_Homo sapiens_hsa052110.41297343
115Biosynthesis of amino acids_Homo sapiens_hsa012300.39763492
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39295160
117ABC transporters_Homo sapiens_hsa020100.38842894
118Ras signaling pathway_Homo sapiens_hsa040140.37872577
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36740292
120Mineral absorption_Homo sapiens_hsa049780.36406034
121Cholinergic synapse_Homo sapiens_hsa047250.35613957
122Staphylococcus aureus infection_Homo sapiens_hsa051500.34823019
123Rap1 signaling pathway_Homo sapiens_hsa040150.32918104
124cAMP signaling pathway_Homo sapiens_hsa040240.32775871
125Thyroid hormone synthesis_Homo sapiens_hsa049180.32321360
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32012848
127Glutathione metabolism_Homo sapiens_hsa004800.31809244
128Insulin signaling pathway_Homo sapiens_hsa049100.31510781
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31162284
130Adherens junction_Homo sapiens_hsa045200.30927595
131Carbon metabolism_Homo sapiens_hsa012000.30487915
132Axon guidance_Homo sapiens_hsa043600.28833142
133Insulin resistance_Homo sapiens_hsa049310.28712966
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27803063
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27771385
136Purine metabolism_Homo sapiens_hsa002300.27441470
137Starch and sucrose metabolism_Homo sapiens_hsa005000.27166228
138Glutamatergic synapse_Homo sapiens_hsa047240.26864783
139Fatty acid biosynthesis_Homo sapiens_hsa000610.26707862
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26345285
141Dorso-ventral axis formation_Homo sapiens_hsa043200.25612607
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25384264
143Calcium signaling pathway_Homo sapiens_hsa040200.25150417
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24870523
145Oxidative phosphorylation_Homo sapiens_hsa001900.24529739

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