RGS10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)6.80027791
2negative regulation of calcium ion transport into cytosol (GO:0010523)5.67258736
3neutrophil activation involved in immune response (GO:0002283)4.85316127
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.65975852
5G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.42392188
6thrombin receptor signaling pathway (GO:0070493)4.20042454
7positive regulation of mast cell activation (GO:0033005)4.16921685
8microglial cell activation (GO:0001774)4.06122697
9aggressive behavior (GO:0002118)3.96990443
10regulation of platelet aggregation (GO:0090330)3.96308392
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.90593566
12negative regulation of cell killing (GO:0031342)3.90593566
13modulation by symbiont of host immune response (GO:0052553)3.84363782
14positive regulation by symbiont of host defense response (GO:0052509)3.84363782
15modulation by symbiont of host defense response (GO:0052031)3.84363782
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84363782
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84363782
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.84363782
19regulation of platelet activation (GO:0010543)3.75334721
20Arp2/3 complex-mediated actin nucleation (GO:0034314)3.65760736
21myeloid cell activation involved in immune response (GO:0002275)3.55013394
22purinergic nucleotide receptor signaling pathway (GO:0035590)3.53286020
23positive regulation of macrophage differentiation (GO:0045651)3.53136901
24macrophage activation involved in immune response (GO:0002281)3.53083433
25platelet aggregation (GO:0070527)3.47407670
26lipoxygenase pathway (GO:0019372)3.45384528
27negative regulation of myeloid cell apoptotic process (GO:0033033)3.44676874
28regulation of interferon-beta biosynthetic process (GO:0045357)3.44665429
29negative regulation of norepinephrine secretion (GO:0010700)3.40729954
30B cell mediated immunity (GO:0019724)3.40424491
31regulation of B cell receptor signaling pathway (GO:0050855)3.36649396
32negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.33709473
33positive regulation of B cell mediated immunity (GO:0002714)3.32626901
34positive regulation of immunoglobulin mediated immune response (GO:0002891)3.32626901
35behavioral response to pain (GO:0048266)3.32139730
36angiogenesis involved in wound healing (GO:0060055)3.30862146
37positive regulation of mast cell degranulation (GO:0043306)3.28149436
38positive regulation of mast cell activation involved in immune response (GO:0033008)3.28149436
39regulation of T cell tolerance induction (GO:0002664)3.27216301
40negative regulation of thymocyte apoptotic process (GO:0070244)3.25837301
41negative regulation of interleukin-12 production (GO:0032695)3.23281682
42respiratory burst (GO:0045730)3.23005082
43protein neddylation (GO:0045116)3.22520921
44leukocyte migration involved in inflammatory response (GO:0002523)3.22015644
45regulation of regulatory T cell differentiation (GO:0045589)3.18952125
46positive regulation of B cell differentiation (GO:0045579)3.18728506
47regulation of T-helper 1 cell differentiation (GO:0045625)3.17570995
48granulocyte activation (GO:0036230)3.16797570
49peripheral nervous system neuron development (GO:0048935)3.15311744
50adenosine receptor signaling pathway (GO:0001973)3.14857174
51response to acidic pH (GO:0010447)3.13868226
52megakaryocyte development (GO:0035855)3.13795506
53positive regulation of isotype switching (GO:0045830)3.09525441
54mast cell activation (GO:0045576)3.08977343
55G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.08350896
56leukocyte degranulation (GO:0043299)3.08282642
57neutrophil activation (GO:0042119)3.07424382
58regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.07237461
59antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05480057
60detection of temperature stimulus involved in sensory perception (GO:0050961)3.02839581
61detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.02839581
62regulation of monocyte chemotaxis (GO:0090025)3.02024207
63positive regulation of gamma-delta T cell activation (GO:0046645)3.01281242
64regulation of alpha-beta T cell proliferation (GO:0046640)3.01195591
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.00709864
66response to peptidoglycan (GO:0032494)3.00362305
67antigen processing and presentation of endogenous antigen (GO:0019883)2.98810401
68negative regulation of T cell apoptotic process (GO:0070233)2.98688626
69positive regulation of granulocyte differentiation (GO:0030854)2.98154351
70cytidine catabolic process (GO:0006216)2.96958229
71cytidine deamination (GO:0009972)2.96958229
72cytidine metabolic process (GO:0046087)2.96958229
73positive regulation of alpha-beta T cell proliferation (GO:0046641)2.96872629
74negative regulation of homotypic cell-cell adhesion (GO:0034111)2.96804682
75detection of temperature stimulus (GO:0016048)2.96131498
76positive regulation of interferon-alpha production (GO:0032727)2.95486618
77actin nucleation (GO:0045010)2.93467528
78chaperone-mediated protein transport (GO:0072321)2.93307292
79positive regulation of antigen processing and presentation (GO:0002579)2.92990703
80negative thymic T cell selection (GO:0045060)2.92838157
81regulation of penile erection (GO:0060405)2.92628991
82negative regulation of T-helper cell differentiation (GO:0045623)2.90971026
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.90971026
84positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.89639049
85regulation of gamma-delta T cell activation (GO:0046643)2.89040406
86negative T cell selection (GO:0043383)2.88992799
87regulation of MHC class II biosynthetic process (GO:0045346)2.88277738
88purinergic receptor signaling pathway (GO:0035587)2.86195912
89neuronal action potential propagation (GO:0019227)2.85865432
90regulation of homotypic cell-cell adhesion (GO:0034110)2.84716685
91negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.83980287
92regulation of amyloid precursor protein catabolic process (GO:1902991)2.83176987
93tolerance induction (GO:0002507)2.82340198
94erythrocyte maturation (GO:0043249)2.81699037
95regulation of myeloid leukocyte mediated immunity (GO:0002886)2.81565437
96regulation of interferon-alpha production (GO:0032647)2.81179065
97positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80955195
98regulation of interleukin-17 production (GO:0032660)2.80932194
99negative regulation of cation channel activity (GO:2001258)2.79265983
100regulation of natural killer cell mediated immunity (GO:0002715)2.79234679
101regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.79234679
102regulation of chronic inflammatory response (GO:0002676)2.78918331
103phagosome maturation (GO:0090382)2.78055854
104positive regulation of DNA recombination (GO:0045911)2.77180324
105membrane raft organization (GO:0031579)2.76899885
106regulation of mast cell activation (GO:0033003)2.74662016
107cellular response to interferon-beta (GO:0035458)2.73993712
108regulation of leukocyte degranulation (GO:0043300)2.73871932
109autophagic vacuole fusion (GO:0000046)2.73648020
110mast cell degranulation (GO:0043303)2.73623457
111mast cell activation involved in immune response (GO:0002279)2.73623457
112antigen processing and presentation via MHC class Ib (GO:0002475)2.73567393
113negative regulation of mast cell activation (GO:0033004)2.72675146
114T cell costimulation (GO:0031295)2.71941080
115regulation of integrin activation (GO:0033623)2.71284380
116myeloid dendritic cell differentiation (GO:0043011)2.70954477
117response to water (GO:0009415)2.70798335
118lymphocyte costimulation (GO:0031294)2.70412626
119negative regulation of platelet activation (GO:0010544)2.69109578
120cellular extravasation (GO:0045123)2.68767113
121negative regulation of interleukin-17 production (GO:0032700)2.68733156
122regulation of B cell mediated immunity (GO:0002712)2.67812618
123regulation of B cell differentiation (GO:0045577)2.67681452
124T cell migration (GO:0072678)2.66539633
125positive regulation of interleukin-17 production (GO:0032740)2.66230877
126response to host immune response (GO:0052572)2.66213022
127response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66213022
128T cell proliferation (GO:0042098)2.66011100
129myeloid dendritic cell activation (GO:0001773)2.65264855
130negative regulation of dendrite morphogenesis (GO:0050774)2.64573764
131B cell receptor signaling pathway (GO:0050853)2.63821055
132macrophage activation (GO:0042116)2.63685863
133pyrimidine nucleoside catabolic process (GO:0046135)2.62223488
134leukocyte mediated cytotoxicity (GO:0001909)2.61969654
135regulation of dopamine secretion (GO:0014059)2.61929443
136negative regulation of erythrocyte differentiation (GO:0045647)2.61868215
137cellular response to thyroid hormone stimulus (GO:0097067)2.59954924
138homotypic cell-cell adhesion (GO:0034109)2.59767882
139positive regulation of natural killer cell mediated immunity (GO:0002717)2.59431417
140triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.57666738
141myeloid leukocyte activation (GO:0002274)2.57603035
142negative regulation of heart rate (GO:0010459)2.55826117
143positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.55737880
144regulation of immunoglobulin mediated immune response (GO:0002889)2.54992571
145negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.54939895
146positive regulation of type 2 immune response (GO:0002830)2.54737652
147positive thymic T cell selection (GO:0045059)2.53537723
148immunoglobulin mediated immune response (GO:0016064)2.53241111
149positive regulation of monocyte chemotaxis (GO:0090026)2.52850091
150response to pain (GO:0048265)2.52748186
151regulation of mast cell degranulation (GO:0043304)2.51910014
152mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.51019554
153regulation of antigen processing and presentation (GO:0002577)2.50731806
154transferrin transport (GO:0033572)2.50256260
155energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.47906548
156ATP hydrolysis coupled proton transport (GO:0015991)2.47906548
157dendritic cell differentiation (GO:0097028)2.45679076
158regulation of interleukin-2 biosynthetic process (GO:0045076)2.45553543
159interferon-gamma-mediated signaling pathway (GO:0060333)2.45020573
160regulation of mast cell activation involved in immune response (GO:0033006)2.44442442
161negative regulation of granulocyte differentiation (GO:0030853)2.43249169
162negative regulation of catecholamine secretion (GO:0033604)2.41828329
163positive regulation of synaptic transmission, GABAergic (GO:0032230)2.40389548
164negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.37452896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.78854185
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.62477057
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.86287692
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.19636796
5* FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.06633539
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.59229733
7SCL_19346495_ChIP-Seq_HPC-7_Human3.38701789
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.09757242
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01106286
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95621325
11TAF15_26573619_Chip-Seq_HEK293_Human2.69288264
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51735031
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49303187
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.47784564
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45630949
16RUNX_20019798_ChIP-Seq_JUKART_Human2.35313617
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29532264
18GATA1_22025678_ChIP-Seq_K562_Human2.28144525
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26673645
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.20850408
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17560451
22GATA1_19941826_ChIP-Seq_K562_Human2.12745631
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.07000711
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97096918
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94616058
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92111082
27* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.90127500
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86806910
29* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.85086805
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83398703
31* SPI1_23127762_ChIP-Seq_K562_Human1.73249574
32SRY_22984422_ChIP-ChIP_TESTIS_Rat1.71722743
33* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71644212
34* SPI1_23547873_ChIP-Seq_NB4_Human1.71565683
35GATA2_19941826_ChIP-Seq_K562_Human1.70603855
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69362614
37GATA2_22383799_ChIP-Seq_G1ME_Mouse1.69242449
38* MYC_22102868_ChIP-Seq_BL_Human1.67935074
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67445773
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.66204987
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.64912318
42MYB_26560356_Chip-Seq_TH2_Human1.61049327
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.52948981
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.49990847
45EZH2_22144423_ChIP-Seq_EOC_Human1.49762593
46MAF_26560356_Chip-Seq_TH1_Human1.49414270
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47829825
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46902509
49KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.41102556
50EGR1_19032775_ChIP-ChIP_M12_Human1.40074838
51VDR_24763502_ChIP-Seq_THP-1_Human1.38018062
52* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37801943
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32894192
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32633493
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30657063
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30169322
57VDR_24787735_ChIP-Seq_THP-1_Human1.29866584
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26306859
59NCOR1_26117541_ChIP-Seq_K562_Human1.25702868
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25613439
61* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25590901
62* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24512240
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22436938
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21304498
65STAT1_20625510_ChIP-Seq_HELA_Human1.21188927
66MAF_26560356_Chip-Seq_TH2_Human1.20242800
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.20099077
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17796199
69* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16594168
70* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16539904
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15822726
72VDR_21846776_ChIP-Seq_THP-1_Human1.13090892
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.12888854
74TCF7_22412390_ChIP-Seq_EML_Mouse1.12604430
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12085898
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11831162
77* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09677450
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09487690
79* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08961121
80* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08935763
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08808634
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08654795
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07847798
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07294879
85PU_27001747_Chip-Seq_BMDM_Mouse1.05426953
86* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04755357
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04221723
88BCL6_27268052_Chip-Seq_Bcells_Human1.03420940
89GATA3_27048872_Chip-Seq_THYMUS_Human1.02848136
90REST_21632747_ChIP-Seq_MESCs_Mouse1.02788932
91WT1_19549856_ChIP-ChIP_CCG9911_Human1.02694549
92* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01371421
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01067481
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00481919
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00264837
96P300_19829295_ChIP-Seq_ESCs_Human1.00035794
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.98426738
98* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98360809
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97687950
100MYB_26560356_Chip-Seq_TH1_Human0.97663698
101BCOR_27268052_Chip-Seq_Bcells_Human0.95576544
102* GATA3_26560356_Chip-Seq_TH2_Human0.95509013
103REST_18959480_ChIP-ChIP_MESCs_Mouse0.94317480
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93910959
105STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92621866
106GATA1_19941827_ChIP-Seq_MEL_Mouse0.91931681
107* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90793262
108TFEB_21752829_ChIP-Seq_HELA_Human0.90483126
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90337509
110ETS1_22383799_ChIP-Seq_G1ME_Mouse0.89841259
111ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89312522
112BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87738574
113RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87436214
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86842389
115CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86562164
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85495948
117UTX_26944678_Chip-Seq_JUKART_Human0.85400071
118ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85286733
119* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.85117888
120* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.85117888
121PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84786579
122SPI1_20517297_ChIP-Seq_HL60_Human0.83729730
123CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83661461
124* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.83523057
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.83366058
126* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83353044
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82774115
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82609905
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82440213
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79521414
131ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79037523
132P300_27268052_Chip-Seq_Bcells_Human0.78707850
133SMAD4_21799915_ChIP-Seq_A2780_Human0.78391139
134* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77717835
135SMRT_27268052_Chip-Seq_Bcells_Human0.76655244
136SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.76284882
137* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.75984619

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception3.92748870
2MP0001835_abnormal_antigen_presentation3.90750552
3MP0001968_abnormal_touch/_nociception3.27688699
4MP0002736_abnormal_nociception_after3.25036583
5MP0005671_abnormal_response_to2.99575090
6MP0002148_abnormal_hypersensitivity_rea2.96246036
7MP0006082_CNS_inflammation2.90384253
8MP0008004_abnormal_stomach_pH2.89176760
9MP0004510_myositis2.66426735
10MP0001986_abnormal_taste_sensitivity2.63914417
11MP0005000_abnormal_immune_tolerance2.61531087
12MP0002733_abnormal_thermal_nociception2.47942635
13MP0001970_abnormal_pain_threshold2.40425343
14MP0000465_gastrointestinal_hemorrhage2.33044640
15MP0005058_abnormal_lysosome_morphology2.29404979
16MP0003436_decreased_susceptibility_to2.28754000
17MP0005387_immune_system_phenotype2.20908528
18MP0001790_abnormal_immune_system2.20908528
19MP0001800_abnormal_humoral_immune2.15047939
20MP0009785_altered_susceptibility_to2.14716751
21MP0002419_abnormal_innate_immunity2.10131094
22MP0004859_abnormal_synaptic_plasticity2.07733726
23MP0000685_abnormal_immune_system2.07135812
24MP0002723_abnormal_immune_serum2.06863966
25MP0003724_increased_susceptibility_to2.05267902
26MP0002452_abnormal_antigen_presenting2.03378962
27MP0002734_abnormal_mechanical_nocicepti2.01516460
28MP0003303_peritoneal_inflammation1.95704280
29MP0004270_analgesia1.95640546
30MP0005025_abnormal_response_to1.92346295
31MP0001819_abnormal_immune_cell1.92164510
32MP0003172_abnormal_lysosome_physiology1.91769167
33MP0002420_abnormal_adaptive_immunity1.90097942
34MP0003183_abnormal_peptide_metabolism1.88736340
35MP0005464_abnormal_platelet_physiology1.87281602
36MP0005310_abnormal_salivary_gland1.78320918
37MP0002163_abnormal_gland_morphology1.74285710
38MP0002064_seizures1.64608327
39MP0002166_altered_tumor_susceptibility1.62887178
40MP0004858_abnormal_nervous_system1.58866657
41MP0002405_respiratory_system_inflammati1.56319326
42MP0003763_abnormal_thymus_physiology1.49423276
43MP0002398_abnormal_bone_marrow1.48586608
44MP0006276_abnormal_autonomic_nervous1.46380670
45MP0003828_pulmonary_edema1.45369874
46MP0002006_tumorigenesis1.43463878
47MP0003656_abnormal_erythrocyte_physiolo1.43296657
48MP0009333_abnormal_splenocyte_physiolog1.42656698
49* MP0000716_abnormal_immune_system1.40223063
50MP0005397_hematopoietic_system_phenotyp1.39807304
51MP0001545_abnormal_hematopoietic_system1.39807304
52MP0003806_abnormal_nucleotide_metabolis1.35291325
53MP0003191_abnormal_cellular_cholesterol1.31914605
54MP0002277_abnormal_respiratory_mucosa1.31605220
55MP0000689_abnormal_spleen_morphology1.30964139
56MP0001845_abnormal_inflammatory_respons1.29389903
57MP0001348_abnormal_lacrimal_gland1.25411231
58MP0001853_heart_inflammation1.23436714
59MP0003880_abnormal_central_pattern1.22994029
60MP0009763_increased_sensitivity_to1.21860961
61MP0002722_abnormal_immune_system1.21643310
62MP0001873_stomach_inflammation1.21132948
63MP0003635_abnormal_synaptic_transmissio1.20931818
64MP0009745_abnormal_behavioral_response1.18687781
65MP0001533_abnormal_skeleton_physiology1.17797551
66MP0002822_catalepsy1.17166394
67MP0003866_abnormal_defecation1.16349010
68MP0009046_muscle_twitch1.15551277
69MP0002067_abnormal_sensory_capabilities1.14790103
70MP0000604_amyloidosis1.11896088
71MP0002877_abnormal_melanocyte_morpholog1.11546242
72MP0008469_abnormal_protein_level1.11257152
73MP0003448_altered_tumor_morphology1.10611562
74MP0002132_abnormal_respiratory_system1.09926460
75* MP0002429_abnormal_blood_cell1.09154930
76MP0002272_abnormal_nervous_system1.08340611
77MP0008874_decreased_physiological_sensi1.04653235
78MP0000249_abnormal_blood_vessel1.02176889
79MP0005379_endocrine/exocrine_gland_phen1.01219241
80MP0005083_abnormal_biliary_tract1.00513398
81MP0000490_abnormal_crypts_of0.99174944
82MP0005167_abnormal_blood-brain_barrier0.98754337
83MP0009379_abnormal_foot_pigmentation0.98272791
84MP0002184_abnormal_innervation0.96407016
85MP0000015_abnormal_ear_pigmentation0.95787830
86MP0002090_abnormal_vision0.95555057
87MP0009278_abnormal_bone_marrow0.95206354
88MP0002638_abnormal_pupillary_reflex0.93330155
89MP0005165_increased_susceptibility_to0.93251539
90MP0002572_abnormal_emotion/affect_behav0.92837415
91MP0009765_abnormal_xenobiotic_induced0.92625273
92MP0003075_altered_response_to0.92450981
93MP0003566_abnormal_cell_adhesion0.92297849
94MP0004811_abnormal_neuron_physiology0.88346412
95MP0009840_abnormal_foam_cell0.88186239
96MP0003638_abnormal_response/metabolism_0.87543355
97MP0004947_skin_inflammation0.85681343
98MP0002396_abnormal_hematopoietic_system0.83926613
99MP0005166_decreased_susceptibility_to0.83554367
100MP0003453_abnormal_keratinocyte_physiol0.83421981
101MP0001440_abnormal_grooming_behavior0.83145507
102MP0000343_altered_response_to0.81846597
103MP0000703_abnormal_thymus_morphology0.81668944
104MP0005451_abnormal_body_composition0.81554983
105MP0000230_abnormal_systemic_arterial0.81242456
106MP0000858_altered_metastatic_potential0.81183649
107MP0003045_fibrosis0.80050876
108MP0005410_abnormal_fertilization0.79660082
109MP0002876_abnormal_thyroid_physiology0.79653362
110MP0004381_abnormal_hair_follicle0.79415943
111MP0003300_gastrointestinal_ulcer0.78301009
112MP0004808_abnormal_hematopoietic_stem0.78233057
113MP0001851_eye_inflammation0.76987745
114MP0005174_abnormal_tail_pigmentation0.76545095
115MP0003186_abnormal_redox_activity0.76065329
116MP0005075_abnormal_melanosome_morpholog0.75623701
117MP0000920_abnormal_myelination0.75276727
118MP0001663_abnormal_digestive_system0.74754780
119MP0008260_abnormal_autophagy0.74072323
120MP0005381_digestive/alimentary_phenotyp0.73870061
121MP0000372_irregular_coat_pigmentation0.73850556
122MP0003879_abnormal_hair_cell0.73263104
123MP0010155_abnormal_intestine_physiology0.72972632
124MP0006054_spinal_hemorrhage0.72814574
125MP0006036_abnormal_mitochondrial_physio0.71123488
126MP0002063_abnormal_learning/memory/cond0.69079222
127MP0005390_skeleton_phenotype0.68990007
128MP0009764_decreased_sensitivity_to0.68957201
129MP0004142_abnormal_muscle_tone0.68546885
130MP0002998_abnormal_bone_remodeling0.68037294
131MP0001270_distended_abdomen0.67748327
132MP0002019_abnormal_tumor_incidence0.67235164
133MP0004883_abnormal_blood_vessel0.66829320
134MP0005084_abnormal_gallbladder_morpholo0.64784688
135* MP0003795_abnormal_bone_structure0.64541459
136MP0005023_abnormal_wound_healing0.63161245
137MP0002138_abnormal_hepatobiliary_system0.60054660
138MP0008872_abnormal_physiological_respon0.59912275
139* MP0009642_abnormal_blood_homeostasis0.58291805
140MP0005164_abnormal_response_to0.57484664
141MP0004036_abnormal_muscle_relaxation0.54146736

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)6.41884107
2Increased mean platelet volume (HP:0011877)6.29290787
3Abnormal platelet volume (HP:0011876)6.22783388
4Myokymia (HP:0002411)6.07033556
5Epistaxis (HP:0000421)5.91121887
6Systemic lupus erythematosus (HP:0002725)4.94569374
7Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.79729115
8Gingival bleeding (HP:0000225)4.78822418
9Recurrent abscess formation (HP:0002722)4.44588353
10Spontaneous hematomas (HP:0007420)4.32758956
11Impaired platelet aggregation (HP:0003540)4.30300647
12Abnormal platelet function (HP:0011869)4.30300647
13Abnormality of glycolipid metabolism (HP:0010969)4.24960636
14Abnormality of liposaccharide metabolism (HP:0010968)4.24960636
15Abnormality of glycosphingolipid metabolism (HP:0004343)4.24960636
16Eczematoid dermatitis (HP:0000976)3.99334290
17Recurrent bacterial skin infections (HP:0005406)3.97930826
18Glomerulonephritis (HP:0000099)3.73127912
19Hyperlipoproteinemia (HP:0010980)3.66261137
20Increased cerebral lipofuscin (HP:0011813)3.44403944
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.44252671
22Febrile seizures (HP:0002373)3.40449174
23Abnormality of macrophages (HP:0004311)3.39981274
24Myotonia (HP:0002486)3.36515360
25Elevated erythrocyte sedimentation rate (HP:0003565)3.30525213
26Abnormal hair whorl (HP:0010721)3.29398022
27Popliteal pterygium (HP:0009756)3.25624574
28Abnormality of the vasculature of the conjunctiva (HP:0008054)3.23905266
29Vacuolated lymphocytes (HP:0001922)3.12228620
30Conjunctival telangiectasia (HP:0000524)3.07744826
31Encephalitis (HP:0002383)3.05554607
32Failure to thrive in infancy (HP:0001531)3.02738045
33Atonic seizures (HP:0010819)3.00151914
34T lymphocytopenia (HP:0005403)2.99561476
35Autoimmune hemolytic anemia (HP:0001890)2.94482912
36Increased IgM level (HP:0003496)2.85788216
37Obstructive lung disease (HP:0006536)2.80147107
38Chronic obstructive pulmonary disease (HP:0006510)2.80147107
39Axonal loss (HP:0003447)2.74496075
40Paralysis (HP:0003470)2.72182098
41J-shaped sella turcica (HP:0002680)2.71601428
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.69777961
43Myositis (HP:0100614)2.66409027
44Mutism (HP:0002300)2.65985518
45Neuroendocrine neoplasm (HP:0100634)2.63781411
46Joint swelling (HP:0001386)2.56112356
47Dyschromatopsia (HP:0007641)2.54564299
48Increased serum ferritin (HP:0003281)2.54379578
49Recurrent fungal infections (HP:0002841)2.53003557
50Vasculitis (HP:0002633)2.52312479
51Poikilocytosis (HP:0004447)2.51893279
52Bruising susceptibility (HP:0000978)2.51446306
53Nephritis (HP:0000123)2.51428525
54Dysostosis multiplex (HP:0000943)2.49791209
55Pheochromocytoma (HP:0002666)2.47862875
56Abnormality of iron homeostasis (HP:0011031)2.47372219
57Sensory axonal neuropathy (HP:0003390)2.47095973
58Abnormality of the prostate (HP:0008775)2.46658505
59Retrobulbar optic neuritis (HP:0100654)2.46599492
60Optic neuritis (HP:0100653)2.46599492
61Hypothermia (HP:0002045)2.45452573
62Abnormality of T cells (HP:0002843)2.44077194
63Acute necrotizing encephalopathy (HP:0006965)2.43579131
64Arterial thrombosis (HP:0004420)2.42083918
65Abnormality of lateral ventricle (HP:0030047)2.42035520
66Recurrent skin infections (HP:0001581)2.38846947
67Chest pain (HP:0100749)2.35257847
68Recurrent gram-negative bacterial infections (HP:0005420)2.31944023
69Acanthocytosis (HP:0001927)2.31090304
70Abnormality of the common coagulation pathway (HP:0010990)2.31023560
71Inflammation of the large intestine (HP:0002037)2.30912914
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.30634985
73Upper motor neuron abnormality (HP:0002127)2.30177043
74Focal motor seizures (HP:0011153)2.30170875
75Petechiae (HP:0000967)2.29631562
76Eosinophilia (HP:0001880)2.27733183
77Gastrointestinal infarctions (HP:0005244)2.27393954
78Progressive macrocephaly (HP:0004481)2.26143398
79Focal seizures (HP:0007359)2.24888395
80Mediastinal lymphadenopathy (HP:0100721)2.24090486
81Orchitis (HP:0100796)2.23975092
82Pulmonary infiltrates (HP:0002113)2.22201392
83IgG deficiency (HP:0004315)2.22197074
84Stomatitis (HP:0010280)2.21288821
85Submucous cleft hard palate (HP:0000176)2.19080284
86Thrombocytosis (HP:0001894)2.18277113
87Complement deficiency (HP:0004431)2.17226623
88Ulnar claw (HP:0001178)2.16907413
89Abnormal pupillary function (HP:0007686)2.16518102
90Gastrointestinal inflammation (HP:0004386)2.16126063
91Increased density of long bones (HP:0006392)2.15932220
92Purpura (HP:0000979)2.15783988
93Progressive inability to walk (HP:0002505)2.15047699
94Granulocytopenia (HP:0001913)2.12412290
95Urticaria (HP:0001025)2.10972685
96Cerebral hemorrhage (HP:0001342)2.10958531
97Leukocytosis (HP:0001974)2.10829416
98Abnormality of eosinophils (HP:0001879)2.10103912
993-Methylglutaconic aciduria (HP:0003535)2.10084486
100Recurrent viral infections (HP:0004429)2.10000498
101Mitochondrial inheritance (HP:0001427)2.09218627
102Prolonged bleeding time (HP:0003010)2.09140186
103Disinhibition (HP:0000734)2.08801147
104Thoracolumbar scoliosis (HP:0002944)2.08521182
105Abnormal mitochondria in muscle tissue (HP:0008316)2.07371551
106Abnormality of the vocal cords (HP:0008777)2.05570484
107Myocardial infarction (HP:0001658)2.05215361
108Hypergammaglobulinemia (HP:0010702)2.04542549
109Thyroiditis (HP:0100646)2.02549705
110Abnormality of cells of the erythroid lineage (HP:0012130)2.01569021
111Abnormality of transition element cation homeostasis (HP:0011030)2.01323103
112Basal ganglia calcification (HP:0002135)2.00504475
113Absence seizures (HP:0002121)2.00483963
114Chronic diarrhea (HP:0002028)2.00218995
115Abnormality of complement system (HP:0005339)2.00180988
116Polycythemia (HP:0001901)1.99900717
117Hemoptysis (HP:0002105)1.99397897
118Nausea (HP:0002018)1.97637105
119Gastrointestinal stroma tumor (HP:0100723)1.96927311
120Hypercortisolism (HP:0001578)1.96625330
121Pulmonary embolism (HP:0002204)1.96514367
122Distal arthrogryposis (HP:0005684)1.96175281
123Agnosia (HP:0010524)1.95755267
124Dialeptic seizures (HP:0011146)1.95652977
125Arthralgia (HP:0002829)1.95169587
126IgM deficiency (HP:0002850)1.95081420
127Episodic fever (HP:0001954)1.94500455
128IgA deficiency (HP:0002720)1.94121718
129Pustule (HP:0200039)1.94085513
130Abnormality of T cell physiology (HP:0011840)1.94005561
131Recurrent cutaneous fungal infections (HP:0011370)1.93475053
132Chronic mucocutaneous candidiasis (HP:0002728)1.93475053
133Exertional dyspnea (HP:0002875)1.93387956
134Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91679455
135Abnormal gallbladder physiology (HP:0012438)1.91382066
136Cholecystitis (HP:0001082)1.91382066
137Meningitis (HP:0001287)1.90998677
138Supranuclear gaze palsy (HP:0000605)1.90709163
139Gingivitis (HP:0000230)1.90517605
140Striae distensae (HP:0001065)1.89783290
141Gangrene (HP:0100758)1.89485115
142Mucosal telangiectasiae (HP:0100579)1.89187103
143Lymphopenia (HP:0001888)1.88571146
144Autoimmune thrombocytopenia (HP:0001973)1.87877304
145Neuronal loss in central nervous system (HP:0002529)1.87861525
146Keratoconjunctivitis sicca (HP:0001097)1.87056654
147Visual hallucinations (HP:0002367)1.86938043
148Postural tremor (HP:0002174)1.85231023
149Retinal atrophy (HP:0001105)1.84147109
150Peripheral hypomyelination (HP:0007182)1.79351246
151Hepatosplenomegaly (HP:0001433)1.78820838
152Progressive cerebellar ataxia (HP:0002073)1.78586368
153Panhypogammaglobulinemia (HP:0003139)1.77767895
154Action tremor (HP:0002345)1.74649416
155Hypokinesia (HP:0002375)1.74525747
156Epileptic encephalopathy (HP:0200134)1.74441221
157Abnormality of T cell number (HP:0011839)1.74287146
158Generalized tonic-clonic seizures (HP:0002069)1.73574675

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK55.45922424
2NME23.32622493
3MAP3K122.81896664
4ARAF2.74266338
5MAP4K12.60258507
6RIPK42.48127123
7PIM22.46215640
8BMX2.45426100
9BLK2.44724610
10TXK2.43061429
11TYK22.39647336
12MAP3K142.24506333
13LIMK12.13872114
14GRK72.11665541
15TBK12.10680001
16TGFBR22.05536930
17EIF2AK12.00967638
18ZAP701.89899854
19MAP3K91.82217538
20IRAK31.80675574
21MAP2K31.78629594
22TAOK21.75953207
23KSR21.72951230
24KIT1.71882477
25FGR1.70894397
26FES1.59750316
27PIK3CG1.58612803
28MAP3K21.55718228
29BMPR1B1.55536344
30SYK1.55276397
31IRAK41.53568763
32TESK11.50016093
33ILK1.47957162
34MAP3K111.47595056
35IKBKE1.45097351
36PTK2B1.44936246
37NTRK31.42778068
38JAK11.36148984
39RET1.32942515
40CSF1R1.32833616
41CASK1.31808000
42ADRBK21.28205719
43IKBKB1.24830246
44MAP3K31.24027463
45TSSK61.23439947
46CDK81.21116576
47LCK1.20127912
48JAK31.16653925
49KDR1.14470867
50SIK31.12333658
51CAMKK21.07494463
52MAPK131.07324542
53MAP3K131.02136621
54HCK1.01349726
55SIK20.99014629
56DAPK20.98598690
57ITK0.97552652
58MST40.97411944
59MAPK120.97080094
60TEC0.96116061
61PRPF4B0.95876843
62TAOK10.92995856
63MATK0.91390684
64PAK10.89802891
65JAK20.88440225
66LYN0.87656272
67DAPK30.86084090
68FGFR30.79614462
69PLK20.79127549
70EPHA30.78619046
71MAP3K50.77037082
72MAPKAPK50.73756344
73MAPKAPK30.73558398
74MINK10.72599358
75RPS6KA20.72092164
76NEK90.71682324
77MAP3K10.67614609
78TESK20.66329481
79NME10.65736329
80NTRK10.65623895
81GRK60.65357840
82MARK30.65106118
83BTK0.62862448
84PDK20.61219681
85ERN10.61030460
86PIM10.60491316
87IRAK10.59899629
88MAP2K70.59521510
89VRK10.57152383
90STK240.56706671
91ADRBK10.56137698
92TLK10.55822623
93DAPK10.54998781
94ACVR1B0.53037196
95BMPR20.52611219
96PDPK10.52601929
97TNK20.51624805
98PRKCD0.50981754
99BRAF0.50806031
100STK30.47681516
101HIPK20.47634437
102CSK0.47132218
103MOS0.46881945
104PRKCQ0.45378885
105STK40.45035956
106ABL20.43241080
107MAPK40.41743554
108CAMKK10.40776014
109MYLK0.40724474
110MAPK110.40676286
111CDC42BPA0.40567771
112FGFR40.39797810
113LRRK20.38722121
114IRAK20.37915250
115CHUK0.36820413
116CDK50.36086797
117STK100.34854109
118TRPM70.34718594
119CDK140.33601354
120YES10.33001763
121CLK10.32874437
122CAMK40.32193463
123PDK10.32086865
124PRKD10.31347853
125IGF1R0.30722796
126TAOK30.30716430
127FYN0.29944807
128SCYL20.29458702
129MAPKAPK20.29435129
130RAF10.29370848
131PDGFRB0.27154625
132EPHB10.24555463
133ABL10.24465835
134PKN10.21621484

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.01451135
2Parkinsons disease_Homo sapiens_hsa050122.54277175
3Collecting duct acid secretion_Homo sapiens_hsa049662.47310375
4Rheumatoid arthritis_Homo sapiens_hsa053232.22639468
5Synaptic vesicle cycle_Homo sapiens_hsa047212.21539142
6Ribosome_Homo sapiens_hsa030102.10090626
7Staphylococcus aureus infection_Homo sapiens_hsa051501.97443888
8Hematopoietic cell lineage_Homo sapiens_hsa046401.94237690
9Alzheimers disease_Homo sapiens_hsa050101.92477204
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.84747324
11Leishmaniasis_Homo sapiens_hsa051401.84612717
12Allograft rejection_Homo sapiens_hsa053301.82082402
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74040625
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70883551
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67801510
16Osteoclast differentiation_Homo sapiens_hsa043801.67727909
17Phagosome_Homo sapiens_hsa041451.58870465
18Pertussis_Homo sapiens_hsa051331.57637184
19Graft-versus-host disease_Homo sapiens_hsa053321.57100019
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.55468428
21Huntingtons disease_Homo sapiens_hsa050161.54532259
22Lysosome_Homo sapiens_hsa041421.54285287
23Primary immunodeficiency_Homo sapiens_hsa053401.52262308
24Type I diabetes mellitus_Homo sapiens_hsa049401.50372992
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49698236
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.48939143
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45519252
28Systemic lupus erythematosus_Homo sapiens_hsa053221.42808153
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42139399
30Tuberculosis_Homo sapiens_hsa051521.40834535
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.40097631
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37072927
33Other glycan degradation_Homo sapiens_hsa005111.35204914
34Measles_Homo sapiens_hsa051621.34189102
35Cardiac muscle contraction_Homo sapiens_hsa042601.32247774
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27077545
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23677650
38B cell receptor signaling pathway_Homo sapiens_hsa046621.22006796
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21313656
40Herpes simplex infection_Homo sapiens_hsa051681.20078093
41Salmonella infection_Homo sapiens_hsa051321.18950775
42Chemokine signaling pathway_Homo sapiens_hsa040621.18283776
43Autoimmune thyroid disease_Homo sapiens_hsa053201.14196075
44Antigen processing and presentation_Homo sapiens_hsa046121.13655246
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08966352
46Vibrio cholerae infection_Homo sapiens_hsa051101.07965105
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.07349422
48T cell receptor signaling pathway_Homo sapiens_hsa046601.07332844
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.06856153
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05110814
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04350615
52Toxoplasmosis_Homo sapiens_hsa051451.00490942
53Proteasome_Homo sapiens_hsa030501.00043295
54Asthma_Homo sapiens_hsa053100.98379487
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97248061
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96271054
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95877325
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92506943
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.92219921
60Arachidonic acid metabolism_Homo sapiens_hsa005900.85582063
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85492026
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84983355
63Legionellosis_Homo sapiens_hsa051340.84773269
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81129799
65Prion diseases_Homo sapiens_hsa050200.80967343
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80755029
67Endocytosis_Homo sapiens_hsa041440.79465108
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78714984
69Influenza A_Homo sapiens_hsa051640.78259263
70Olfactory transduction_Homo sapiens_hsa047400.77888919
71Morphine addiction_Homo sapiens_hsa050320.77638608
72Shigellosis_Homo sapiens_hsa051310.76824032
73Taste transduction_Homo sapiens_hsa047420.76550042
74Viral carcinogenesis_Homo sapiens_hsa052030.74699738
75Apoptosis_Homo sapiens_hsa042100.72832642
76Malaria_Homo sapiens_hsa051440.71178304
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.68210075
78Sulfur metabolism_Homo sapiens_hsa009200.66816456
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66703801
80Non-small cell lung cancer_Homo sapiens_hsa052230.65064733
81Platelet activation_Homo sapiens_hsa046110.64751621
82Viral myocarditis_Homo sapiens_hsa054160.63402122
83Hepatitis B_Homo sapiens_hsa051610.63196055
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62132697
85GABAergic synapse_Homo sapiens_hsa047270.61452674
86Serotonergic synapse_Homo sapiens_hsa047260.60540080
87Regulation of autophagy_Homo sapiens_hsa041400.60437621
88African trypanosomiasis_Homo sapiens_hsa051430.59446873
89Cholinergic synapse_Homo sapiens_hsa047250.58971167
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57909515
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55944521
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55810622
93Acute myeloid leukemia_Homo sapiens_hsa052210.55049266
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54542553
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53644954
96TNF signaling pathway_Homo sapiens_hsa046680.52735233
97Prolactin signaling pathway_Homo sapiens_hsa049170.52359698
98HIF-1 signaling pathway_Homo sapiens_hsa040660.52255587
99Salivary secretion_Homo sapiens_hsa049700.50919839
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50675085
101Glutamatergic synapse_Homo sapiens_hsa047240.50624309
102Hepatitis C_Homo sapiens_hsa051600.49377558
103Nicotine addiction_Homo sapiens_hsa050330.49374634
104HTLV-I infection_Homo sapiens_hsa051660.48963205
105Chronic myeloid leukemia_Homo sapiens_hsa052200.48213294
106Pancreatic cancer_Homo sapiens_hsa052120.45159405
107Epstein-Barr virus infection_Homo sapiens_hsa051690.44713897
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43865600
109VEGF signaling pathway_Homo sapiens_hsa043700.42576837
110Alcoholism_Homo sapiens_hsa050340.41186712
111Glioma_Homo sapiens_hsa052140.40957251
112Long-term potentiation_Homo sapiens_hsa047200.40897086
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39884432
114Amoebiasis_Homo sapiens_hsa051460.39883014
115Long-term depression_Homo sapiens_hsa047300.39580802
116Thyroid cancer_Homo sapiens_hsa052160.38338740
117Dorso-ventral axis formation_Homo sapiens_hsa043200.38337316
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.38324082
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.35848038
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.35789550
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.34483349
122Glutathione metabolism_Homo sapiens_hsa004800.33517218
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33265956
124Bladder cancer_Homo sapiens_hsa052190.32910852
125ECM-receptor interaction_Homo sapiens_hsa045120.30320292
126Renal cell carcinoma_Homo sapiens_hsa052110.29477724
127Small cell lung cancer_Homo sapiens_hsa052220.28146965
128Renin-angiotensin system_Homo sapiens_hsa046140.25161111
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24331898
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24115228
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21500413
132Ras signaling pathway_Homo sapiens_hsa040140.20602481
133Pentose phosphate pathway_Homo sapiens_hsa000300.19522656
134Nitrogen metabolism_Homo sapiens_hsa009100.19363555

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