RGS12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)4.40018946
2behavioral response to nicotine (GO:0035095)4.22667938
3positive regulation of synapse maturation (GO:0090129)4.08162760
4layer formation in cerebral cortex (GO:0021819)4.08104124
5membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.03109510
6gamma-aminobutyric acid transport (GO:0015812)4.00693949
7planar cell polarity pathway involved in neural tube closure (GO:0090179)3.86520385
8auditory behavior (GO:0031223)3.80171423
9pyrimidine nucleobase catabolic process (GO:0006208)3.69813541
10neurotransmitter-gated ion channel clustering (GO:0072578)3.69341887
11hemidesmosome assembly (GO:0031581)3.66789928
12synaptic vesicle maturation (GO:0016188)3.63760934
13regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.56369971
14establishment of planar polarity (GO:0001736)3.45581921
15establishment of tissue polarity (GO:0007164)3.45581921
16lymph vessel development (GO:0001945)3.43293692
17locomotory exploration behavior (GO:0035641)3.42312749
18parturition (GO:0007567)3.41601116
19regulation of synapse maturation (GO:0090128)3.38950223
20G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.37388589
21regulation of short-term neuronal synaptic plasticity (GO:0048172)3.36510547
22regulation of synapse structural plasticity (GO:0051823)3.36393042
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.36321517
24central nervous system myelination (GO:0022010)3.31941082
25axon ensheathment in central nervous system (GO:0032291)3.31941082
26transmission of nerve impulse (GO:0019226)3.31586268
27neuron cell-cell adhesion (GO:0007158)3.31210006
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30164666
29presynaptic membrane assembly (GO:0097105)3.28046923
30lateral sprouting from an epithelium (GO:0060601)3.27776145
31vocalization behavior (GO:0071625)3.27561859
32negative regulation of norepinephrine secretion (GO:0010700)3.24343693
33presynaptic membrane organization (GO:0097090)3.21698233
34synaptic transmission, glutamatergic (GO:0035249)3.19842246
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.18159298
36response to auditory stimulus (GO:0010996)3.17862844
37negative regulation of oligodendrocyte differentiation (GO:0048715)3.15952074
38phenylpropanoid metabolic process (GO:0009698)3.10902643
39neuronal action potential propagation (GO:0019227)3.09540880
40dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.08265232
41membrane depolarization during action potential (GO:0086010)3.04290553
42negative regulation of catenin import into nucleus (GO:0035414)3.03503509
43nucleobase catabolic process (GO:0046113)3.01477223
44synaptic vesicle exocytosis (GO:0016079)2.99537492
45synaptic vesicle docking involved in exocytosis (GO:0016081)2.97881533
46cardiac right ventricle morphogenesis (GO:0003215)2.94145446
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93884334
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.93315447
49desmosome organization (GO:0002934)2.93111987
50hippo signaling (GO:0035329)2.92452792
51neuromuscular synaptic transmission (GO:0007274)2.87791824
52startle response (GO:0001964)2.87560021
53glutamate receptor signaling pathway (GO:0007215)2.86728767
54mechanosensory behavior (GO:0007638)2.80287626
55synapse assembly (GO:0007416)2.79299848
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75661039
57negative regulation of chondrocyte differentiation (GO:0032331)2.75252282
58limb bud formation (GO:0060174)2.74557828
59glutamate secretion (GO:0014047)2.71019262
60regulation of cardioblast proliferation (GO:0003264)2.70723324
61regulation of secondary heart field cardioblast proliferation (GO:0003266)2.70723324
62spinal cord development (GO:0021510)2.69702124
63cochlea morphogenesis (GO:0090103)2.69566784
64outer ear morphogenesis (GO:0042473)2.68953654
65neurotransmitter secretion (GO:0007269)2.68133970
66endocardial cushion morphogenesis (GO:0003203)2.66858035
67negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66498684
68paraxial mesoderm development (GO:0048339)2.66077356
69epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.64184628
70renal system development (GO:0072001)2.63752606
71dendritic spine morphogenesis (GO:0060997)2.63685769
72positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.63504945
73ovulation cycle (GO:0042698)2.63178443
74regulation of microtubule-based movement (GO:0060632)2.61883593
75glycerophospholipid catabolic process (GO:0046475)2.60231846
76positive regulation of dendritic spine development (GO:0060999)2.59817525
77regulation of axon extension involved in axon guidance (GO:0048841)2.59144020
78establishment of nucleus localization (GO:0040023)2.58366909
79membrane depolarization (GO:0051899)2.58118399
80negative regulation of axon extension involved in axon guidance (GO:0048843)2.54589270
81somatic stem cell division (GO:0048103)2.53968298
82proline transport (GO:0015824)2.53079897
83regulation of excitatory postsynaptic membrane potential (GO:0060079)2.52236655
84protein polyglutamylation (GO:0018095)2.52226565
85epithelial cilium movement (GO:0003351)2.51807057
86neuron-neuron synaptic transmission (GO:0007270)2.51512017
87atrial septum morphogenesis (GO:0060413)2.51162890
88aorta morphogenesis (GO:0035909)2.50862596
89cardiac ventricle morphogenesis (GO:0003208)2.50829423
90cilium movement (GO:0003341)2.50150749
91cell migration in hindbrain (GO:0021535)2.49886491
92regulation of postsynaptic membrane potential (GO:0060078)2.48038888
93primary amino compound metabolic process (GO:1901160)2.47907569
94adult walking behavior (GO:0007628)2.47640252
95lymphangiogenesis (GO:0001946)2.44864947
96dendrite morphogenesis (GO:0048813)2.44663661
97atrioventricular valve morphogenesis (GO:0003181)2.44197429
98negative regulation of dendrite development (GO:2000171)2.43995726
99neuronal action potential (GO:0019228)2.43433783
100calcium ion-dependent exocytosis (GO:0017156)2.43265490
101cell-substrate junction assembly (GO:0007044)2.42545695
102axonemal dynein complex assembly (GO:0070286)2.42540534
103retinal ganglion cell axon guidance (GO:0031290)2.42158945
104axoneme assembly (GO:0035082)2.41740700
105non-canonical Wnt signaling pathway (GO:0035567)2.40996687
106serotonin metabolic process (GO:0042428)2.40875338
107alanine transport (GO:0032328)2.40546513
108cardiac chamber morphogenesis (GO:0003206)2.40263232
109heart valve formation (GO:0003188)2.40193901
110neuromuscular process controlling posture (GO:0050884)2.39605085
111detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39478411
112neuronal ion channel clustering (GO:0045161)2.38691563
113axon extension involved in axon guidance (GO:0048846)2.37542448
114neuron projection extension involved in neuron projection guidance (GO:1902284)2.37542448
115negative regulation of catecholamine secretion (GO:0033604)2.37255785
116regulation of glutamate receptor signaling pathway (GO:1900449)2.36595083
117nephron tubule morphogenesis (GO:0072078)2.36347823
118nephron epithelium morphogenesis (GO:0072088)2.36347823
119C4-dicarboxylate transport (GO:0015740)2.36336185
120positive regulation of synapse assembly (GO:0051965)2.36163867
121cilium or flagellum-dependent cell motility (GO:0001539)2.36052966
122cochlea development (GO:0090102)2.35947798
123exploration behavior (GO:0035640)2.35618619
124regulation of neuronal synaptic plasticity (GO:0048168)2.35519872
125regulation of neurotransmitter levels (GO:0001505)2.34769908
126synapse organization (GO:0050808)2.34587819
127regulation of cilium movement (GO:0003352)2.34518045
128mesenchyme morphogenesis (GO:0072132)2.34420681
129dosage compensation (GO:0007549)2.33814943
130multicellular organismal signaling (GO:0035637)2.33708721
131regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.33217337
132Notch signaling involved in heart development (GO:0061314)2.33124993
133behavioral response to ethanol (GO:0048149)2.33028946
134cardiac myofibril assembly (GO:0055003)2.32943576
135Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.32523600
136glial cell proliferation (GO:0014009)2.32472113
137somite development (GO:0061053)2.32340617
138regulation of neurotransmitter uptake (GO:0051580)2.31969355
139negative regulation of astrocyte differentiation (GO:0048712)2.30903068
140regulation of axon guidance (GO:1902667)2.30723055
141cell surface receptor signaling pathway involved in heart development (GO:0061311)2.30476009
142regulation of action potential (GO:0098900)2.30296970
143negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.30159328
144positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.30147127
145vascular endothelial growth factor signaling pathway (GO:0038084)2.29615731
146cerebral cortex radially oriented cell migration (GO:0021799)2.29402492
147outflow tract morphogenesis (GO:0003151)2.29233259
148germ cell migration (GO:0008354)2.28332547
149phosphorelay signal transduction system (GO:0000160)2.27960705
150adult behavior (GO:0030534)2.27871247
151heart valve morphogenesis (GO:0003179)2.27552998
152nucleosome disassembly (GO:0006337)2.26675458
153protein-DNA complex disassembly (GO:0032986)2.26675458
154neuronal stem cell maintenance (GO:0097150)2.22674023
155chondrocyte proliferation (GO:0035988)2.21527431
156generation of neurons (GO:0048699)2.21458654
157regulation of establishment of planar polarity (GO:0090175)2.20866687
158central nervous system projection neuron axonogenesis (GO:0021952)2.20696373
159protein localization to synapse (GO:0035418)2.19395012
160adherens junction assembly (GO:0034333)2.19140891
161regulation of hippo signaling (GO:0035330)2.18960626
162axonal fasciculation (GO:0007413)2.18612561
163negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.18560128
164cell migration involved in heart development (GO:0060973)2.18302340
165plasma membrane repair (GO:0001778)2.18301341
166cytoskeletal anchoring at plasma membrane (GO:0007016)2.18032304
167neuron recognition (GO:0008038)2.17265196
168cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.17241970
169proximal/distal pattern formation (GO:0009954)2.16918738
170cell proliferation in forebrain (GO:0021846)2.16697349
171regulation of heart morphogenesis (GO:2000826)2.16199872
172RNA localization (GO:0006403)2.14515536
173negative regulation of cartilage development (GO:0061037)2.14408835
174epithelial cell-cell adhesion (GO:0090136)2.14191997
175forebrain neuron differentiation (GO:0021879)2.12084856
176neural tube development (GO:0021915)2.11735160
177morphogenesis of an endothelium (GO:0003159)2.11679284
178endothelial tube morphogenesis (GO:0061154)2.11679284
179negative regulation of axon guidance (GO:1902668)2.11494098
180adherens junction organization (GO:0034332)2.09128196
181regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.08495224
182regulation of NFAT protein import into nucleus (GO:0051532)2.08196020
183positive regulation of epithelial to mesenchymal transition (GO:0010718)2.07969010
184positive regulation of digestive system process (GO:0060456)2.06286410
185regulation of development, heterochronic (GO:0040034)2.05653322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.97313414
2EZH2_22144423_ChIP-Seq_EOC_Human4.61638237
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.96606874
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.87934194
5EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.69579341
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55352591
7GBX2_23144817_ChIP-Seq_PC3_Human2.48303142
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41009297
9REST_21632747_ChIP-Seq_MESCs_Mouse2.34850066
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34092290
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27307257
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27307257
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.27234171
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.26762546
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26232152
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.23591116
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.17431782
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14613953
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.11722345
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07056683
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06606779
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04741114
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98822341
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98571680
25RING1B_27294783_Chip-Seq_ESCs_Mouse1.93401309
26TP53_20018659_ChIP-ChIP_R1E_Mouse1.92870397
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89218328
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88633472
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.88470160
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.86847993
31RING1B_27294783_Chip-Seq_NPCs_Mouse1.86785352
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.81780025
33ZNF263_19887448_ChIP-Seq_K562_Human1.81502379
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.81284138
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.75671424
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75133489
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71861253
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.71478980
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70851939
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.67655434
41ISL1_27105846_Chip-Seq_CPCs_Mouse1.67334269
42VDR_22108803_ChIP-Seq_LS180_Human1.66858408
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65242118
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63459399
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62467991
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60250365
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59641074
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59284825
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.58342629
50AR_21572438_ChIP-Seq_LNCaP_Human1.56407974
51* KDM2B_26808549_Chip-Seq_K562_Human1.55154199
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54510915
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51527525
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51238257
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43551012
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42649186
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41807086
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40753227
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37772669
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37772669
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.36475568
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35825953
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34767375
64RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34234882
65* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34008874
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33877551
67* KDM2B_26808549_Chip-Seq_JURKAT_Human1.31921464
68E2F7_22180533_ChIP-Seq_HELA_Human1.30231163
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28045201
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27947825
71ZNF274_21170338_ChIP-Seq_K562_Hela1.27767140
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25219396
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.24846206
74TCF4_18268006_ChIP-ChIP_LS174T_Human1.22522404
75AHR_22903824_ChIP-Seq_MCF-7_Human1.20584603
76CTCF_27219007_Chip-Seq_Bcells_Human1.20428032
77* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20122605
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19729067
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18724441
80SMAD4_21799915_ChIP-Seq_A2780_Human1.18619726
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18582902
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17876761
83TP53_18474530_ChIP-ChIP_U2OS_Human1.17682826
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17637972
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17381156
86* KDM2B_26808549_Chip-Seq_DND41_Human1.17308083
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.15681862
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14761158
89AR_25329375_ChIP-Seq_VCAP_Human1.11690257
90P300_19829295_ChIP-Seq_ESCs_Human1.11403194
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11218341
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09148703
93* AR_19668381_ChIP-Seq_PC3_Human1.09050413
94RNF2_27304074_Chip-Seq_NSC_Mouse1.09023766
95STAT3_23295773_ChIP-Seq_U87_Human1.07962343
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07575875
97SOX2_16153702_ChIP-ChIP_HESCs_Human1.07342606
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06947531
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06846693
100RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05850911
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05525557
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.05364779
103* EP300_21415370_ChIP-Seq_HL-1_Mouse1.04547121
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04095907
105WT1_19549856_ChIP-ChIP_CCG9911_Human1.03985763
106CLOCK_20551151_ChIP-Seq_293T_Human1.02991809
107SMAD3_21741376_ChIP-Seq_ESCs_Human1.02385706
108* TCF4_23295773_ChIP-Seq_U87_Human1.02313838
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01474061
110TCF7_22412390_ChIP-Seq_EML_Mouse1.01190399
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.01155502
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00944403
113* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99812551
114DROSHA_22980978_ChIP-Seq_HELA_Human0.99483382
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99418272
116YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99042179
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98581082
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97540833
119POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97377003
120BCAT_22108803_ChIP-Seq_LS180_Human0.96817584
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96190665
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96102321
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95688025
124TAF15_26573619_Chip-Seq_HEK293_Human0.94894216
125IGF1R_20145208_ChIP-Seq_DFB_Human0.94747913
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94374800
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94271373
128* RUNX2_22187159_ChIP-Seq_PCA_Human0.94131196
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93382938
130ELK3_25401928_ChIP-Seq_HUVEC_Human0.93352383
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93094910
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92773709
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92486593
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.92475494
135* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92280103
136* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91871254
137CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90372497
138KDM2B_26808549_Chip-Seq_REH_Human0.89063379
139* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88594643
140* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88157895
141LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88092931
142TP53_16413492_ChIP-PET_HCT116_Human0.87239395
143ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87222796
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87170086
145BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87009556
146RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86718167
147KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86329215
148RARB_27405468_Chip-Seq_BRAIN_Mouse0.86221002
149PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85151557
150CBP_20019798_ChIP-Seq_JUKART_Human0.84868629
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84868629
152KLF5_25053715_ChIP-Seq_YYC3_Human0.84016203
153KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83608360
154SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82842780
155FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82778562
156* RUNX1_27514584_Chip-Seq_MCF-7_Human0.82388237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.82197115
2MP0000537_abnormal_urethra_morphology3.10258428
3MP0003880_abnormal_central_pattern2.95424058
4MP0003136_yellow_coat_color2.77765917
5MP0008789_abnormal_olfactory_epithelium2.67761918
6MP0002254_reproductive_system_inflammat2.64352916
7MP0004270_analgesia2.46296191
8MP0005499_abnormal_olfactory_system2.41114904
9MP0005394_taste/olfaction_phenotype2.41114904
10MP0002064_seizures2.40627720
11MP0009745_abnormal_behavioral_response2.39518219
12MP0002063_abnormal_learning/memory/cond2.25925930
13MP0004885_abnormal_endolymph2.25544373
14MP0005423_abnormal_somatic_nervous2.24860678
15MP0001486_abnormal_startle_reflex2.21494897
16MP0001968_abnormal_touch/_nociception2.19898643
17MP0009379_abnormal_foot_pigmentation2.19071382
18MP0002272_abnormal_nervous_system2.18129371
19MP0005646_abnormal_pituitary_gland2.12372246
20MP0009046_muscle_twitch2.11436099
21MP0009053_abnormal_anal_canal2.10221971
22MP0002572_abnormal_emotion/affect_behav2.10197755
23MP0003385_abnormal_body_wall2.09881370
24MP0003941_abnormal_skin_development2.02492611
25MP0002734_abnormal_mechanical_nocicepti2.02298186
26MP0002653_abnormal_ependyma_morphology1.97140780
27MP0005623_abnormal_meninges_morphology1.95473845
28MP0005171_absent_coat_pigmentation1.94929055
29MP0002735_abnormal_chemical_nociception1.91323129
30MP0001984_abnormal_olfaction1.90113026
31MP0000467_abnormal_esophagus_morphology1.88086912
32MP0001879_abnormal_lymphatic_vessel1.86767024
33MP0005377_hearing/vestibular/ear_phenot1.85937683
34MP0003878_abnormal_ear_physiology1.85937683
35MP0000049_abnormal_middle_ear1.85397518
36MP0000566_synostosis1.83426858
37MP0003705_abnormal_hypodermis_morpholog1.79513386
38MP0004272_abnormal_basement_membrane1.79485875
39MP0002249_abnormal_larynx_morphology1.76774440
40MP0002638_abnormal_pupillary_reflex1.75490692
41MP0003115_abnormal_respiratory_system1.73374296
42MP0001346_abnormal_lacrimal_gland1.72516713
43MP0005167_abnormal_blood-brain_barrier1.71270361
44MP0005551_abnormal_eye_electrophysiolog1.69096362
45MP0001970_abnormal_pain_threshold1.68366285
46MP0001485_abnormal_pinna_reflex1.68101536
47MP0002736_abnormal_nociception_after1.64163889
48MP0002557_abnormal_social/conspecific_i1.62669427
49MP0006276_abnormal_autonomic_nervous1.59163964
50MP0005275_abnormal_skin_tensile1.57332220
51MP0002733_abnormal_thermal_nociception1.56553541
52MP0000534_abnormal_ureter_morphology1.56446186
53MP0010368_abnormal_lymphatic_system1.54797575
54MP0002282_abnormal_trachea_morphology1.51955894
55MP0004133_heterotaxia1.51758845
56MP0009250_abnormal_appendicular_skeleto1.51135176
57MP0000762_abnormal_tongue_morphology1.50859669
58MP0001501_abnormal_sleep_pattern1.47811171
59MP0009384_cardiac_valve_regurgitation1.47157833
60MP0002234_abnormal_pharynx_morphology1.47082193
61MP0001958_emphysema1.46673773
62MP0002067_abnormal_sensory_capabilities1.44354470
63MP0003879_abnormal_hair_cell1.39167008
64MP0003283_abnormal_digestive_organ1.38730984
65MP0000778_abnormal_nervous_system1.38719573
66MP0003755_abnormal_palate_morphology1.36746861
67MP0002233_abnormal_nose_morphology1.36644316
68MP0001440_abnormal_grooming_behavior1.36225473
69MP0000026_abnormal_inner_ear1.35984698
70MP0003942_abnormal_urinary_system1.33734235
71MP0000955_abnormal_spinal_cord1.32373181
72MP0002882_abnormal_neuron_morphology1.31937634
73MP0001502_abnormal_circadian_rhythm1.26419257
74MP0003122_maternal_imprinting1.24243757
75MP0001986_abnormal_taste_sensitivity1.21967252
76MP0004742_abnormal_vestibular_system1.21282840
77MP0005248_abnormal_Harderian_gland1.21013884
78MP0001963_abnormal_hearing_physiology1.20056254
79MP0002098_abnormal_vibrissa_morphology1.19397000
80MP0005076_abnormal_cell_differentiation1.18704113
81MP0003633_abnormal_nervous_system1.16806901
82MP0000428_abnormal_craniofacial_morphol1.16065542
83MP0000383_abnormal_hair_follicle1.15705884
84MP0003935_abnormal_craniofacial_develop1.15327866
85MP0002796_impaired_skin_barrier1.15153427
86MP0004142_abnormal_muscle_tone1.15128532
87MP0003861_abnormal_nervous_system1.14984805
88MP0002877_abnormal_melanocyte_morpholog1.14786433
89MP0003119_abnormal_digestive_system1.14426483
90MP0004043_abnormal_pH_regulation1.12990015
91MP0003566_abnormal_cell_adhesion1.12460295
92MP0003937_abnormal_limbs/digits/tail_de1.11619319
93MP0006292_abnormal_olfactory_placode1.11545096
94MP0005386_behavior/neurological_phenoty1.11059928
95MP0004924_abnormal_behavior1.11059928
96MP0004859_abnormal_synaptic_plasticity1.10923730
97MP0001270_distended_abdomen1.09080629
98MP0002116_abnormal_craniofacial_bone1.09020575
99MP0002752_abnormal_somatic_nervous1.08296165
100MP0005367_renal/urinary_system_phenotyp1.08263203
101MP0000516_abnormal_urinary_system1.08263203
102MP0003121_genomic_imprinting1.06436548
103MP0002102_abnormal_ear_morphology1.05532682
104MP0000631_abnormal_neuroendocrine_gland1.05214909
105MP0002229_neurodegeneration1.04934430
106MP0005253_abnormal_eye_physiology1.04606078
107MP0000751_myopathy1.03968814
108MP0004215_abnormal_myocardial_fiber1.02778970
109MP0008438_abnormal_cutaneous_collagen1.01754295
110MP0001849_ear_inflammation1.01741985
111MP0003329_amyloid_beta_deposits1.00881193
112MP0002909_abnormal_adrenal_gland0.99834492
113MP0003631_nervous_system_phenotype0.99002891
114MP0006138_congestive_heart_failure0.98719244
115MP0000733_abnormal_muscle_development0.98533793
116MP0003632_abnormal_nervous_system0.98125163
117MP0002152_abnormal_brain_morphology0.97628033
118MP0005195_abnormal_posterior_eye0.97619711
119MP0008569_lethality_at_weaning0.97123147
120MP0010234_abnormal_vibrissa_follicle0.97002027
121MP0008007_abnormal_cellular_replicative0.96217489
122MP0002066_abnormal_motor_capabilities/c0.95386035
123MP0002876_abnormal_thyroid_physiology0.95085029
124MP0008877_abnormal_DNA_methylation0.93869680
125MP0003828_pulmonary_edema0.93425961
126MP0004147_increased_porphyrin_level0.93256414
127MP0008875_abnormal_xenobiotic_pharmacok0.92668029
128MP0002177_abnormal_outer_ear0.92382698
129MP0002938_white_spotting0.91961764
130MP0000579_abnormal_nail_morphology0.91221025
131MP0009780_abnormal_chondrocyte_physiolo0.90935269
132MP0005187_abnormal_penis_morphology0.90688679
133MP0010386_abnormal_urinary_bladder0.90506240
134MP0006054_spinal_hemorrhage0.90048814
135MP0005501_abnormal_skin_physiology0.89707591
136MP0010352_gastrointestinal_tract_polyps0.89674548
137MP0004145_abnormal_muscle_electrophysio0.89646659
138MP0004811_abnormal_neuron_physiology0.89397465
139MP0001905_abnormal_dopamine_level0.89109688
140MP0002081_perinatal_lethality0.88414437
141MP0004130_abnormal_muscle_cell0.87850379
142MP0003091_abnormal_cell_migration0.86835924
143MP0000569_abnormal_digit_pigmentation0.86567777
144MP0002184_abnormal_innervation0.86202546
145MP0002822_catalepsy0.86074331
146MP0010678_abnormal_skin_adnexa0.85910125
147MP0008995_early_reproductive_senescence0.85243319
148MP0002925_abnormal_cardiovascular_devel0.84579096
149MP0002138_abnormal_hepatobiliary_system0.84229767
150MP0002932_abnormal_joint_morphology0.84193456
151MP0003938_abnormal_ear_development0.82538252
152MP0005174_abnormal_tail_pigmentation0.82531908
153MP0003634_abnormal_glial_cell0.82429800
154MP0003011_delayed_dark_adaptation0.81471568
155MP0000767_abnormal_smooth_muscle0.81316110
156MP0005409_darkened_coat_color0.81284482
157MP0002697_abnormal_eye_size0.81175431
158MP0002095_abnormal_skin_pigmentation0.80858810
159MP0003172_abnormal_lysosome_physiology0.80604393
160MP0003195_calcinosis0.80108631
161MP0005508_abnormal_skeleton_morphology0.80061594
162MP0006072_abnormal_retinal_apoptosis0.78623316
163MP0004085_abnormal_heartbeat0.78303839
164MP0010630_abnormal_cardiac_muscle0.77989369
165MP0008872_abnormal_physiological_respon0.77805624
166MP0002060_abnormal_skin_morphology0.77751001
167MP0002133_abnormal_respiratory_system0.76759224
168MP0005388_respiratory_system_phenotype0.76759224
169MP0000432_abnormal_head_morphology0.75643197
170MP0003123_paternal_imprinting0.75075770
171MP0009278_abnormal_bone_marrow0.74691364
172MP0005503_abnormal_tendon_morphology0.72462754
173MP0003635_abnormal_synaptic_transmissio0.72071998
174MP0003787_abnormal_imprinting0.71735672
175MP0002085_abnormal_embryonic_tissue0.71692548
176MP0003279_aneurysm0.70328890
177MP0002111_abnormal_tail_morphology0.70296564
178MP0004084_abnormal_cardiac_muscle0.70233833

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)3.75600837
2Progressive cerebellar ataxia (HP:0002073)3.63946097
3Focal seizures (HP:0007359)3.62054692
4Focal motor seizures (HP:0011153)3.53765027
5Short 4th metacarpal (HP:0010044)3.39845200
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.39845200
7Myokymia (HP:0002411)3.28951503
8Genetic anticipation (HP:0003743)3.24726904
9Nephronophthisis (HP:0000090)3.21689106
10Abnormality of midbrain morphology (HP:0002418)3.11540581
11Molar tooth sign on MRI (HP:0002419)3.11540581
12True hermaphroditism (HP:0010459)3.04359409
13Epileptic encephalopathy (HP:0200134)2.97451017
14Milia (HP:0001056)2.97446629
15Febrile seizures (HP:0002373)2.93630836
16Atrophic scars (HP:0001075)2.92984675
17Shallow orbits (HP:0000586)2.90047128
18Abnormal respiratory motile cilium morphology (HP:0005938)2.83221943
19Abnormal respiratory epithelium morphology (HP:0012253)2.83221943
20Pancreatic cysts (HP:0001737)2.74982955
21Hemiparesis (HP:0001269)2.74815521
22Morphological abnormality of the middle ear (HP:0008609)2.71965555
23Congenital stationary night blindness (HP:0007642)2.71389965
24Pancreatic fibrosis (HP:0100732)2.69052773
25Type II lissencephaly (HP:0007260)2.65279211
26Abnormality of the renal medulla (HP:0100957)2.61762511
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.61543237
28Absent/shortened dynein arms (HP:0200106)2.61543237
29Abnormality of the 4th metacarpal (HP:0010012)2.59245922
30Cystic liver disease (HP:0006706)2.56179030
31Atonic seizures (HP:0010819)2.51822307
32Abnormal drinking behavior (HP:0030082)2.50019447
33Polydipsia (HP:0001959)2.50019447
34Onycholysis (HP:0001806)2.49585306
35Broad-based gait (HP:0002136)2.49146815
36Fragile nails (HP:0001808)2.48807512
37Chronic hepatic failure (HP:0100626)2.48351998
38Bronchomalacia (HP:0002780)2.45091965
39Abnormality of binocular vision (HP:0011514)2.43927686
40Diplopia (HP:0000651)2.43927686
41Congenital sensorineural hearing impairment (HP:0008527)2.42846403
42Protrusio acetabuli (HP:0003179)2.42338989
43Hyperacusis (HP:0010780)2.40297260
44Limb dystonia (HP:0002451)2.39428085
45Renal duplication (HP:0000075)2.38052055
46Protruding tongue (HP:0010808)2.37804950
47Absent speech (HP:0001344)2.34398469
48Morphological abnormality of the inner ear (HP:0011390)2.34197584
49Progressive inability to walk (HP:0002505)2.32315448
50Abnormal ciliary motility (HP:0012262)2.32303067
51Bladder diverticulum (HP:0000015)2.31124927
52Urinary bladder sphincter dysfunction (HP:0002839)2.28525323
53Neurofibrillary tangles (HP:0002185)2.25846636
54Polyphagia (HP:0002591)2.25621592
55Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24735013
56Selective tooth agenesis (HP:0001592)2.23540360
57Fragile skin (HP:0001030)2.21230080
58Visual hallucinations (HP:0002367)2.21183197
59Dialeptic seizures (HP:0011146)2.20783793
60Gait imbalance (HP:0002141)2.17761374
61Esophageal atresia (HP:0002032)2.17423773
62Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.17397595
63Agitation (HP:0000713)2.16259901
64Trigonocephaly (HP:0000243)2.16202269
65Aplasia of the phalanges of the hand (HP:0009802)2.15337668
66Aplasia involving bones of the extremities (HP:0009825)2.15337668
67Aplasia involving bones of the upper limbs (HP:0009823)2.15337668
68Drooling (HP:0002307)2.12653558
69Premature rupture of membranes (HP:0001788)2.12363507
70Down-sloping shoulders (HP:0200021)2.12303667
71Action tremor (HP:0002345)2.10020019
72Generalized tonic-clonic seizures (HP:0002069)2.09544356
73Hemiplegia (HP:0002301)2.08730929
74Retinal atrophy (HP:0001105)2.07415258
75Medial flaring of the eyebrow (HP:0010747)2.07132768
76Cerebral aneurysm (HP:0004944)2.05019942
77Gaze-evoked nystagmus (HP:0000640)2.04847654
78Aplasia cutis congenita (HP:0001057)2.04032241
79Midline defect of the nose (HP:0004122)2.03878517
80Ankyloglossia (HP:0010296)2.03532655
81Status epilepticus (HP:0002133)2.02970851
82Tubular atrophy (HP:0000092)2.00900679
83Insomnia (HP:0100785)2.00737216
84Absence seizures (HP:0002121)1.99935540
85Ulnar claw (HP:0001178)1.99629583
86Renal dysplasia (HP:0000110)1.99337152
87Retinal dysplasia (HP:0007973)1.97999100
88Decreased central vision (HP:0007663)1.97894483
89Blue irides (HP:0000635)1.97475274
90Cerebellar dysplasia (HP:0007033)1.97356638
91Abnormal respiratory motile cilium physiology (HP:0012261)1.96325333
92Germ cell neoplasia (HP:0100728)1.95002084
93Abnormality of the heme biosynthetic pathway (HP:0010472)1.94800495
94Deviation of the hallux (HP:0010051)1.94649228
95Hallux valgus (HP:0001822)1.94582147
96Occipital encephalocele (HP:0002085)1.94038987
97Missing ribs (HP:0000921)1.93424092
98Abnormal eating behavior (HP:0100738)1.92507083
99Overgrowth (HP:0001548)1.92238326
100Right ventricular cardiomyopathy (HP:0011663)1.91488475
101Renovascular hypertension (HP:0100817)1.91326687
102Decreased circulating renin level (HP:0003351)1.89140420
103Sleep apnea (HP:0010535)1.88381018
104Tracheomalacia (HP:0002779)1.87165475
105Megalencephaly (HP:0001355)1.86841117
106Skull defect (HP:0001362)1.86597407
107Abnormality of cochlea (HP:0000375)1.84870100
108Abolished electroretinogram (ERG) (HP:0000550)1.84735803
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84387031
110Pachygyria (HP:0001302)1.84049779
111Rib fusion (HP:0000902)1.83502251
112Excessive salivation (HP:0003781)1.83326983
113Prolonged QT interval (HP:0001657)1.82680955
114Sclerocornea (HP:0000647)1.79890072
115Abnormality of the diencephalon (HP:0010662)1.79850977
116Mutism (HP:0002300)1.79573325
117Congenital hepatic fibrosis (HP:0002612)1.79079394
118Wrist flexion contracture (HP:0001239)1.77805632
119Lip pit (HP:0100267)1.77716755
120Inability to walk (HP:0002540)1.77158229
121Amblyopia (HP:0000646)1.76983605
122Short middle phalanx of the 5th finger (HP:0004220)1.76935857
123Natal tooth (HP:0000695)1.76422060
124Elfin facies (HP:0004428)1.76145541
125Abnormality of oral frenula (HP:0000190)1.75893354
126Woolly hair (HP:0002224)1.75749545
127Buphthalmos (HP:0000557)1.75677247
128Ankle contracture (HP:0006466)1.74177693
129Flat cornea (HP:0007720)1.73635725
130Increased neuronal autofluorescent lipopigment (HP:0002074)1.73564680
131Overriding aorta (HP:0002623)1.73472091
132Aplasia/Hypoplasia of the sternum (HP:0006714)1.73143401
133Lower limb amyotrophy (HP:0007210)1.72207531
134Increased corneal curvature (HP:0100692)1.71581050
135Keratoconus (HP:0000563)1.71581050
136Abnormality of the aortic arch (HP:0012303)1.71449403
137Bowel diverticulosis (HP:0005222)1.70904284
138Clumsiness (HP:0002312)1.70759935
139Congenital primary aphakia (HP:0007707)1.70501533
140Polyuria (HP:0000103)1.69423263
141Absent eyebrow (HP:0002223)1.69277460
142Abnormality of dentin (HP:0010299)1.68975087
143Pendular nystagmus (HP:0012043)1.68829563
144Shawl scrotum (HP:0000049)1.68204917
145Cutaneous finger syndactyly (HP:0010554)1.67902814
146Mesangial abnormality (HP:0001966)1.67736305
147Plantar hyperkeratosis (HP:0007556)1.67582257
148Abnormality of the renal cortex (HP:0011035)1.67461647
149Pointed chin (HP:0000307)1.67186608
150Lissencephaly (HP:0001339)1.66531328
151Arterial tortuosity (HP:0005116)1.65433304
152Abnormality of the renal collecting system (HP:0004742)1.64571267
153Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.64127039
154Sudden death (HP:0001699)1.63511714
155Tented upper lip vermilion (HP:0010804)1.63310803
156Broad metatarsal (HP:0001783)1.63289964
157Increased cerebral lipofuscin (HP:0011813)1.62432809
158Hypotrichosis (HP:0001006)1.62078754
159Asymmetry of the thorax (HP:0001555)1.61806053
160Ventricular tachycardia (HP:0004756)1.61559563
161Macroglossia (HP:0000158)1.61089626
162Cutaneous syndactyly (HP:0012725)1.58348175
163Absent frontal sinuses (HP:0002688)1.57668092
164Advanced eruption of teeth (HP:0006288)1.57280863
165Vascular tortuosity (HP:0004948)1.57037759
166Anophthalmia (HP:0000528)1.56811750
167Abnormal number of incisors (HP:0011064)1.56611415
168Aortic dissection (HP:0002647)1.56005222
169Bicuspid aortic valve (HP:0001647)1.52623369
170Lymphangioma (HP:0100764)1.52457874
171Increased connective tissue (HP:0009025)1.51675074
172Dilatation of the ascending aorta (HP:0005111)1.51518124
173Laryngomalacia (HP:0001601)1.51242070
174Neonatal short-limb short stature (HP:0008921)1.51122274
175Hydroureter (HP:0000072)1.50462489
176Fibular aplasia (HP:0002990)1.50371017
177Facial diplegia (HP:0001349)1.48022162
178Sacral dimple (HP:0000960)1.47710709
179Rectal prolapse (HP:0002035)1.46514696
180Mesomelia (HP:0003027)1.45693829
181Mildly elevated creatine phosphokinase (HP:0008180)1.45591679
182Narrow nasal bridge (HP:0000446)1.45026838
183Exotropia (HP:0000577)1.44273269
184Atresia of the external auditory canal (HP:0000413)1.43592610
185Obsessive-compulsive behavior (HP:0000722)1.43551377
186Vesicoureteral reflux (HP:0000076)1.43306026
187Tarsal synostosis (HP:0008368)1.41820308
188Hypoplastic toenails (HP:0001800)1.41397972
189Scapular winging (HP:0003691)1.40659990
190Gastrointestinal atresia (HP:0002589)1.40291003
191Arnold-Chiari malformation (HP:0002308)1.40184180
192Short 5th finger (HP:0009237)1.40053660
193Aqueductal stenosis (HP:0002410)1.39467855
194Broad toe (HP:0001837)1.39032930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.58563658
2EEF2K3.18962735
3EPHB23.02318378
4EPHA43.01226454
5FRK2.91370245
6TRIB32.57412645
7PKN22.44702943
8PASK2.42443823
9MAPK152.41210110
10INSRR2.39304031
11PRKD32.20272167
12ADRBK22.12494282
13MAP3K102.09460648
14TTN2.01851716
15PINK11.98606587
16TESK11.96212555
17PDGFRA1.94274218
18LATS21.86151518
19PTK2B1.80843545
20WNK41.76996578
21FER1.73842424
22CAMKK11.70927056
23ERBB31.63484866
24NTRK21.60562397
25SIK21.60053145
26TGFBR11.51289553
27FGFR21.47142672
28PAK41.45816645
29DYRK1B1.42985142
30PRKCG1.42755852
31MAPKAPK31.42440781
32SGK4941.41455008
33SGK2231.41455008
34RIPK11.40854554
35GRK11.39986120
36TIE11.38529661
37MAP3K41.38479242
38RPS6KB21.36262727
39MINK11.36170745
40BMPR1B1.33622811
41DDR21.31123995
42MARK11.24885121
43PAK31.24587025
44DYRK21.24010811
45WNK31.22176947
46TYRO31.21378363
47SGK21.20103562
48PTK61.18848758
49CAMK1D1.18841373
50CDC71.17844377
51ICK1.15734765
52STK38L1.15696767
53MAP4K21.14831952
54ACVR1B1.14376208
55PHKG11.14020830
56PHKG21.14020830
57ILK1.13956386
58TLK11.10846768
59NEK21.09808480
60DMPK1.09398725
61MAPK131.07626996
62LRRK21.07560510
63CDK81.06622895
64PNCK1.05785493
65MAP2K61.05696712
66PKN11.04156655
67PLK21.04041835
68CDK61.01171660
69PAK21.00524231
70LMTK20.97555372
71CDK50.95529114
72KSR10.94908794
73PRKCH0.94841773
74CAMK10.93042228
75CSNK1G20.88695524
76MKNK20.88132116
77ROCK10.87650705
78RET0.87448281
79PDK40.87164796
80PDK30.87164796
81ERBB40.86175710
82FGFR30.84014293
83UHMK10.83961986
84MKNK10.83656989
85RPS6KA20.82958797
86ERBB20.79677721
87CAMK2A0.79094187
88MAP2K20.77639959
89CDC42BPA0.76764019
90RPS6KA60.76747671
91FGFR10.76023588
92CAMKK20.73496611
93SCYL20.73321784
94MAP2K10.72762908
95PRKCE0.72379541
96STK380.72253689
97TAOK30.72124871
98MUSK0.71300980
99DAPK30.70569059
100OXSR10.69664967
101LIMK10.69295972
102STK390.68450129
103SGK10.67346839
104PRKCZ0.67263121
105ROCK20.66728386
106SGK30.65193164
107MAPKAPK50.64532017
108CAMK2B0.64443993
109CAMK40.63992117
110MYLK0.63908850
111TAOK10.62861521
112NTRK30.62475176
113MAP2K40.61190092
114PTK20.58417241
115CAMK1G0.58314432
116BRSK10.58014467
117TGFBR20.56890402
118RPS6KA10.55543570
119DAPK20.55104091
120RPS6KA40.54204330
121DYRK1A0.54049054
122PAK60.52989492
123WNK10.52228038
124BMX0.51932490
125PRKACA0.51908794
126NTRK10.51888598
127TRPM70.50926076
128MAP3K60.50835526
129TNK20.50504134
130ALK0.48964914
131MAP3K70.48662211
132MAP2K70.48017744
133CDK140.47245504
134AKT20.46859805
135RPS6KL10.46731598
136RPS6KC10.46731598
137STK110.46683114
138CSNK1A10.46469423
139MATK0.45988265
140PRKD10.45813580
141PRKD20.45010933
142MAPK90.44418733
143MARK20.43736863
144GRK50.43709860
145SIK30.43503408
146MTOR0.42991712
147SIK10.42672899
148PRKAA10.42460047
149BCKDK0.42180031
150CSNK1A1L0.40985689
151SRC0.40734302
152PDGFRB0.40370679
153AKT10.40277670
154ADRBK10.39490739
155BCR0.39490655
156MAP3K110.39389691
157PRKG10.39387797
158RPS6KA30.39241105
159CSNK1G30.39186883
160PRKCA0.38907492
161MAPK80.38593098
162CSNK1D0.38591070
163TNIK0.38389342
164PIK3CA0.36309886

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.31423447
2Phototransduction_Homo sapiens_hsa047442.21694334
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07245838
4Synaptic vesicle cycle_Homo sapiens_hsa047212.05396525
5Insulin secretion_Homo sapiens_hsa049112.01126714
6Linoleic acid metabolism_Homo sapiens_hsa005911.98411205
7Hippo signaling pathway_Homo sapiens_hsa043901.96182722
8Axon guidance_Homo sapiens_hsa043601.90775968
9Hedgehog signaling pathway_Homo sapiens_hsa043401.83130391
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.77667195
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67972152
12Dilated cardiomyopathy_Homo sapiens_hsa054141.67248795
13Small cell lung cancer_Homo sapiens_hsa052221.65777775
14ECM-receptor interaction_Homo sapiens_hsa045121.60745503
15Ether lipid metabolism_Homo sapiens_hsa005651.58918206
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57214979
17Cocaine addiction_Homo sapiens_hsa050301.55158074
18MicroRNAs in cancer_Homo sapiens_hsa052061.52913563
19Melanogenesis_Homo sapiens_hsa049161.51195727
20Focal adhesion_Homo sapiens_hsa045101.50925642
21Proteoglycans in cancer_Homo sapiens_hsa052051.50038937
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.49015238
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.48531600
24Colorectal cancer_Homo sapiens_hsa052101.46669514
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45879367
26Notch signaling pathway_Homo sapiens_hsa043301.44964590
27Glioma_Homo sapiens_hsa052141.42732835
28Wnt signaling pathway_Homo sapiens_hsa043101.38774080
29Amphetamine addiction_Homo sapiens_hsa050311.37222522
30Butanoate metabolism_Homo sapiens_hsa006501.35782653
31Bladder cancer_Homo sapiens_hsa052191.33980041
32Endometrial cancer_Homo sapiens_hsa052131.33107064
33Nitrogen metabolism_Homo sapiens_hsa009101.32828259
34Chronic myeloid leukemia_Homo sapiens_hsa052201.31144984
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29621032
36Adherens junction_Homo sapiens_hsa045201.29529392
37Dorso-ventral axis formation_Homo sapiens_hsa043201.28477933
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27835044
39Calcium signaling pathway_Homo sapiens_hsa040201.26870484
40Histidine metabolism_Homo sapiens_hsa003401.25532737
41Non-small cell lung cancer_Homo sapiens_hsa052231.23247418
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20553176
43Estrogen signaling pathway_Homo sapiens_hsa049151.19693495
44VEGF signaling pathway_Homo sapiens_hsa043701.17875563
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17201297
46Gap junction_Homo sapiens_hsa045401.16333304
47Pathways in cancer_Homo sapiens_hsa052001.15143456
48ABC transporters_Homo sapiens_hsa020101.13663894
49Oxytocin signaling pathway_Homo sapiens_hsa049211.13490112
50Rap1 signaling pathway_Homo sapiens_hsa040151.11582948
51GnRH signaling pathway_Homo sapiens_hsa049121.10887420
52TGF-beta signaling pathway_Homo sapiens_hsa043501.10880597
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10015162
54Cardiac muscle contraction_Homo sapiens_hsa042601.09341310
55Melanoma_Homo sapiens_hsa052181.08571292
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08507577
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08027119
58HTLV-I infection_Homo sapiens_hsa051661.04254051
59Tryptophan metabolism_Homo sapiens_hsa003801.04164718
60Alcoholism_Homo sapiens_hsa050341.04120551
61Long-term depression_Homo sapiens_hsa047301.03116617
62Oocyte meiosis_Homo sapiens_hsa041141.03115483
63ErbB signaling pathway_Homo sapiens_hsa040121.03109553
64Collecting duct acid secretion_Homo sapiens_hsa049661.02755581
65Renin secretion_Homo sapiens_hsa049241.02334235
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02006029
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01245386
68Tight junction_Homo sapiens_hsa045301.00743222
69Viral myocarditis_Homo sapiens_hsa054160.98733558
70Gastric acid secretion_Homo sapiens_hsa049710.98549612
71Bile secretion_Homo sapiens_hsa049760.95849945
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95295572
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95258186
74mRNA surveillance pathway_Homo sapiens_hsa030150.92311779
75Cell cycle_Homo sapiens_hsa041100.92261911
76Pancreatic cancer_Homo sapiens_hsa052120.91756213
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91738602
78Olfactory transduction_Homo sapiens_hsa047400.90026096
79GABAergic synapse_Homo sapiens_hsa047270.88404580
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88055720
81Circadian entrainment_Homo sapiens_hsa047130.87870382
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.87839641
83Spliceosome_Homo sapiens_hsa030400.87683658
84Renal cell carcinoma_Homo sapiens_hsa052110.87480372
85Cholinergic synapse_Homo sapiens_hsa047250.87397841
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87094364
87p53 signaling pathway_Homo sapiens_hsa041150.86802531
88Chemical carcinogenesis_Homo sapiens_hsa052040.86520589
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85590070
90Dopaminergic synapse_Homo sapiens_hsa047280.83796334
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83555537
92Caffeine metabolism_Homo sapiens_hsa002320.81948805
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81938993
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.81920283
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.81062515
96Amoebiasis_Homo sapiens_hsa051460.80840153
97Toxoplasmosis_Homo sapiens_hsa051450.80409143
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.79335681
99Prostate cancer_Homo sapiens_hsa052150.79335666
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78471554
101Morphine addiction_Homo sapiens_hsa050320.77140490
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76015232
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75675199
104Glutamatergic synapse_Homo sapiens_hsa047240.75327517
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.75320333
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74974957
107MAPK signaling pathway_Homo sapiens_hsa040100.74872126
108Prolactin signaling pathway_Homo sapiens_hsa049170.74576584
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74485919
110Platelet activation_Homo sapiens_hsa046110.73867564
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73732173
112Taste transduction_Homo sapiens_hsa047420.73561405
113Serotonergic synapse_Homo sapiens_hsa047260.73248487
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72834310
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72832781
116Lysosome_Homo sapiens_hsa041420.72212149
117beta-Alanine metabolism_Homo sapiens_hsa004100.71939480
118Nicotine addiction_Homo sapiens_hsa050330.71393886
119Ras signaling pathway_Homo sapiens_hsa040140.70086014
120Retinol metabolism_Homo sapiens_hsa008300.69639802
121Glycerolipid metabolism_Homo sapiens_hsa005610.69435538
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69318888
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69185117
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68274503
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67560071
126Ovarian steroidogenesis_Homo sapiens_hsa049130.67271913
127cAMP signaling pathway_Homo sapiens_hsa040240.67053735
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.67036268
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.66641385
130Systemic lupus erythematosus_Homo sapiens_hsa053220.66448864
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65857087
132Mineral absorption_Homo sapiens_hsa049780.65361686
133Long-term potentiation_Homo sapiens_hsa047200.64863935
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.64093016
135Arachidonic acid metabolism_Homo sapiens_hsa005900.63884783
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.63413295
137mTOR signaling pathway_Homo sapiens_hsa041500.63012775
138Choline metabolism in cancer_Homo sapiens_hsa052310.62643680
139Pancreatic secretion_Homo sapiens_hsa049720.62506591
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62496974
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62387673
142Salivary secretion_Homo sapiens_hsa049700.62356389
143PPAR signaling pathway_Homo sapiens_hsa033200.61238406
144Circadian rhythm_Homo sapiens_hsa047100.59009236
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58352385
146Fatty acid biosynthesis_Homo sapiens_hsa000610.56929457
147Type II diabetes mellitus_Homo sapiens_hsa049300.55968567
148Thyroid hormone synthesis_Homo sapiens_hsa049180.55044862
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51777404
150Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49736525
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.47940110
152Lysine degradation_Homo sapiens_hsa003100.43680345

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