RGS13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)9.56617773
2production of molecular mediator involved in inflammatory response (GO:0002532)8.43967915
3inflammatory response to antigenic stimulus (GO:0002437)8.09538412
4granulocyte differentiation (GO:0030851)6.99678488
5hepatocyte apoptotic process (GO:0097284)6.66383651
6detection of chemical stimulus involved in sensory perception of taste (GO:0050912)5.59646993
7regulation of B cell receptor signaling pathway (GO:0050855)5.52419127
8otic vesicle formation (GO:0030916)5.50130728
9sensory perception of taste (GO:0050909)5.37110634
10B cell receptor signaling pathway (GO:0050853)5.35396110
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.23575040
12response to fungus (GO:0009620)5.18968737
13natural killer cell mediated cytotoxicity (GO:0042267)5.13787619
14natural killer cell mediated immunity (GO:0002228)5.13787619
15regulation of Rap GTPase activity (GO:0032317)5.07795391
16snRNA transcription (GO:0009301)5.00935204
17negative regulation of gene silencing (GO:0060969)4.93095618
18antigen processing and presentation of endogenous antigen (GO:0019883)4.90168461
19detection of chemical stimulus involved in sensory perception (GO:0050907)4.77728168
20icosanoid secretion (GO:0032309)4.45189732
21arachidonic acid secretion (GO:0050482)4.45189732
22icosanoid biosynthetic process (GO:0046456)4.39015963
23fatty acid derivative biosynthetic process (GO:1901570)4.39015963
24positive thymic T cell selection (GO:0045059)4.29645092
25positive regulation of type 2 immune response (GO:0002830)4.24200113
26DNA double-strand break processing (GO:0000729)4.22077947
27eye photoreceptor cell differentiation (GO:0001754)4.21155891
28photoreceptor cell differentiation (GO:0046530)4.21155891
29lipoxygenase pathway (GO:0019372)4.18725599
30maintenance of gastrointestinal epithelium (GO:0030277)4.15072081
31signal peptide processing (GO:0006465)4.13369542
32positive regulation of vesicle fusion (GO:0031340)4.08621647
33regulation of chromatin silencing (GO:0031935)4.08619072
34positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.02084967
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.02084967
36positive regulation of mitotic sister chromatid separation (GO:1901970)4.02084967
37mast cell degranulation (GO:0043303)3.98974152
38mast cell activation involved in immune response (GO:0002279)3.98974152
39germinal center formation (GO:0002467)3.97369549
40epithelial structure maintenance (GO:0010669)3.95376955
41cellular response to antibiotic (GO:0071236)3.92398066
42regulation of macrophage cytokine production (GO:0010935)3.91446270
43positive regulation of extracellular matrix organization (GO:1903055)3.85435063
44mast cell activation (GO:0045576)3.72995383
45regulation of female receptivity (GO:0045924)3.70427756
46phosphatidylinositol acyl-chain remodeling (GO:0036149)3.70025848
47negative regulation of B cell apoptotic process (GO:0002903)3.68843812
48prostanoid biosynthetic process (GO:0046457)3.68213880
49prostaglandin biosynthetic process (GO:0001516)3.68213880
50histone mRNA catabolic process (GO:0071044)3.67178116
51leukotriene biosynthetic process (GO:0019370)3.66686316
52somatic diversification of immunoglobulins (GO:0016445)3.61823379
53fatty acid derivative transport (GO:1901571)3.60938825
54icosanoid transport (GO:0071715)3.60938825
55inositol phosphate dephosphorylation (GO:0046855)3.60592381
56phosphorylated carbohydrate dephosphorylation (GO:0046838)3.60592381
57skin morphogenesis (GO:0043589)3.58300757
58vesicle targeting (GO:0006903)3.53314019
59positive regulation of protein oligomerization (GO:0032461)3.51192394
60serotonin receptor signaling pathway (GO:0007210)3.49988038
61regulation of protein homooligomerization (GO:0032462)3.48129249
62negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.44802932
63sequestering of actin monomers (GO:0042989)3.37562198
64replication fork processing (GO:0031297)3.37132899
65negative regulation of glycogen biosynthetic process (GO:0045719)3.36429003
66positive regulation of fatty acid beta-oxidation (GO:0032000)3.36151202
67low-density lipoprotein particle remodeling (GO:0034374)3.33685777
68positive regulation of gene expression, epigenetic (GO:0045815)3.29063181
69inositol phosphate catabolic process (GO:0071545)3.28222237
70regulation of fibroblast apoptotic process (GO:2000269)3.27235440
71phosphatidylserine acyl-chain remodeling (GO:0036150)3.27166949
72positive T cell selection (GO:0043368)3.26407888
73pyrimidine nucleoside catabolic process (GO:0046135)3.24913628
74regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.23933233
75regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23855449
76positive regulation of male gonad development (GO:2000020)3.23774666
77regulation of interleukin-8 secretion (GO:2000482)3.23102199
78negative regulation of interleukin-8 production (GO:0032717)3.22040242
79detection of light stimulus involved in sensory perception (GO:0050962)3.21993722
80detection of light stimulus involved in visual perception (GO:0050908)3.21993722
81positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.21341227
82negative thymic T cell selection (GO:0045060)3.20161056
83nephron tubule formation (GO:0072079)3.19500956
84phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.17716320
85DNA demethylation (GO:0080111)3.16112520
86positive regulation of B cell differentiation (GO:0045579)3.15950655
87positive regulation of protein homooligomerization (GO:0032464)3.14616579
88negative regulation of bone mineralization (GO:0030502)3.14592677
89notochord development (GO:0030903)3.14494401
90female mating behavior (GO:0060180)3.14461246
91meiotic chromosome segregation (GO:0045132)3.13769600
92cellular response to zinc ion (GO:0071294)3.11130168
93negative regulation by host of viral transcription (GO:0043922)3.10760645
94regulation of B cell apoptotic process (GO:0002902)3.10735523
95telomere maintenance via semi-conservative replication (GO:0032201)3.09744014
96regulation of germinal center formation (GO:0002634)3.09404027
97sphingoid metabolic process (GO:0046519)3.07604559
98long term synaptic depression (GO:0060292)3.07312353
99negative regulation of mast cell activation (GO:0033004)3.06057398
100regulation of centriole replication (GO:0046599)3.05938159
101limb bud formation (GO:0060174)3.04691205
102endocardial cushion morphogenesis (GO:0003203)3.04671419
103carnitine shuttle (GO:0006853)3.03359030
104negative T cell selection (GO:0043383)3.01638079
105regulation of T cell cytokine production (GO:0002724)3.01148536
106sphingosine metabolic process (GO:0006670)3.00534043
107positive regulation of macrophage cytokine production (GO:0060907)3.00340328
108RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.99850083
109double-strand break repair via homologous recombination (GO:0000724)2.97408615
110proline transport (GO:0015824)2.93879049
111recombinational repair (GO:0000725)2.93714634
112regulation of T-helper 2 cell differentiation (GO:0045628)2.92358038
113centriole replication (GO:0007099)2.92170375
114isotype switching (GO:0045190)2.90477874
115somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.90477874
116somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.90477874
117B cell mediated immunity (GO:0019724)2.90199765
118cellular response to ethanol (GO:0071361)2.90060149
119negative regulation of glycogen metabolic process (GO:0070874)2.88915418
120B cell proliferation (GO:0042100)2.88366401
121dendritic cell chemotaxis (GO:0002407)2.86113623
122immunoglobulin mediated immune response (GO:0016064)2.84200162
123diol metabolic process (GO:0034311)2.83744453
124regulation of protein oligomerization (GO:0032459)2.83647272
125cellular response to toxic substance (GO:0097237)2.83297796
126regulation of DNA endoreduplication (GO:0032875)2.83180166
127DNA integration (GO:0015074)2.82613019
128negative regulation of protein oligomerization (GO:0032460)2.82533989
129regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.79839773
130phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.76074303
131photoreceptor cell maintenance (GO:0045494)2.75135515
132synaptic transmission, dopaminergic (GO:0001963)2.73345709
133mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.71800233
134positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.71800233
135B cell activation (GO:0042113)2.71262541
136adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.70778092
137neural tube formation (GO:0001841)2.69867493
138regulation of B cell differentiation (GO:0045577)2.66899959
139indolalkylamine metabolic process (GO:0006586)2.65755359
140regulation of memory T cell differentiation (GO:0043380)2.65550145
141phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.63729028
142response to pheromone (GO:0019236)2.62453291
143detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62274924
144tachykinin receptor signaling pathway (GO:0007217)2.61923149
145piRNA metabolic process (GO:0034587)2.61140600
146positive regulation of granulocyte differentiation (GO:0030854)2.59753347
147negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.58528860
148modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.57231277
149vesicle fusion (GO:0006906)2.56829529
150histone mRNA metabolic process (GO:0008334)2.55500054
151maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.54404457
152somatic recombination of immunoglobulin gene segments (GO:0016447)2.53646550
153B cell homeostasis (GO:0001782)2.53162328
154modulation by host of symbiont transcription (GO:0052472)2.53053906
155modulation by host of viral transcription (GO:0043921)2.53053906
156regulation of interferon-alpha production (GO:0032647)2.52116032
157regulation of gamma-delta T cell differentiation (GO:0045586)2.50934937
158somatic diversification of immune receptors (GO:0002200)2.48487439
159regulation of interferon-beta biosynthetic process (GO:0045357)2.47371911
160positive regulation of interferon-alpha production (GO:0032727)2.47284233
161positive regulation of developmental pigmentation (GO:0048087)2.47014536
162pyrimidine dimer repair (GO:0006290)2.46424634
163auditory receptor cell stereocilium organization (GO:0060088)2.46073825
164regulation of B cell proliferation (GO:0030888)2.44804072
165pseudouridine synthesis (GO:0001522)2.44495121
166regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.43421203
167indole-containing compound catabolic process (GO:0042436)2.42415195
168indolalkylamine catabolic process (GO:0046218)2.42415195
169tryptophan catabolic process (GO:0006569)2.42415195
170positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.42073289
171positive regulation of chromosome segregation (GO:0051984)2.41537633
172transmission of nerve impulse (GO:0019226)2.39400713
173regulation of centrosome duplication (GO:0010824)2.35208480
174positive regulation of B cell proliferation (GO:0030890)2.34297509
175cytidine deamination (GO:0009972)13.7188030
176cytidine metabolic process (GO:0046087)13.7188030
177cytidine catabolic process (GO:0006216)13.7188030
178somatic hypermutation of immunoglobulin genes (GO:0016446)10.1139508
179somatic diversification of immune receptors via somatic mutation (GO:0002566)10.1139508
180pyrimidine ribonucleoside catabolic process (GO:0046133)10.0312772

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.13077041
2E2F7_22180533_ChIP-Seq_HELA_Human5.32122187
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.48870546
4AR_21572438_ChIP-Seq_LNCaP_Human3.84016253
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.64788626
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.13464834
7* FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.05738895
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.00381762
9AR_21909140_ChIP-Seq_LNCAP_Human2.93452945
10MYC_22102868_ChIP-Seq_BL_Human2.85379509
11IGF1R_20145208_ChIP-Seq_DFB_Human2.83749722
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.81725170
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70059915
14VDR_22108803_ChIP-Seq_LS180_Human2.62508086
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.54616032
16FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.46624513
17* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40278822
18ESR1_15608294_ChIP-ChIP_MCF-7_Human2.35809322
19STAT1_20625510_ChIP-Seq_HELA_Human2.34124536
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.29897968
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.27551508
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26813868
23NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.23104338
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.19178751
25PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.12859405
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08905975
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.04541840
28TAF15_26573619_Chip-Seq_HEK293_Human1.98935402
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96992392
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.94873821
31RUNX_20019798_ChIP-Seq_JUKART_Human1.87945900
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.87321240
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84596789
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.83923103
35CDX2_20551321_ChIP-Seq_CACO-2_Human1.82884864
36GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.79925238
37MAF_26560356_Chip-Seq_TH1_Human1.77888333
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.76955941
39ER_23166858_ChIP-Seq_MCF-7_Human1.75251752
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74796780
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73070029
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.72465114
43P300_19829295_ChIP-Seq_ESCs_Human1.72431986
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71467729
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.71155345
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.71001086
47* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70804603
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.70139286
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67172126
50VDR_23849224_ChIP-Seq_CD4+_Human1.66673014
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65552043
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61811767
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61802641
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.61790164
55MYB_26560356_Chip-Seq_TH2_Human1.59121877
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58219309
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58030681
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55858555
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55027860
60TP53_22573176_ChIP-Seq_HFKS_Human1.54807793
61* RUNX1_22412390_ChIP-Seq_EML_Mouse1.54343902
62ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53203244
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52374481
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.46899225
65FOXP3_21729870_ChIP-Seq_TREG_Human1.46605112
66TP53_18474530_ChIP-ChIP_U2OS_Human1.45754209
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45160071
68* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43135389
69MYB_26560356_Chip-Seq_TH1_Human1.39298011
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38093204
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36250710
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34732465
73ELK1_19687146_ChIP-ChIP_HELA_Human1.33969299
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33397309
75SOX2_20726797_ChIP-Seq_SW620_Human1.32337025
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.31100901
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31003800
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29114348
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28751679
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28251945
81VDR_21846776_ChIP-Seq_THP-1_Human1.27944316
82TCF7_22412390_ChIP-Seq_EML_Mouse1.27619227
83GATA3_26560356_Chip-Seq_TH2_Human1.26964469
84SOX2_19829295_ChIP-Seq_ESCs_Human1.26593885
85NANOG_19829295_ChIP-Seq_ESCs_Human1.26593885
86STAT3_23295773_ChIP-Seq_U87_Human1.26536710
87SCL_19346495_ChIP-Seq_HPC-7_Human1.26123535
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25745223
89TCF4_22108803_ChIP-Seq_LS180_Human1.25621590
90BCAT_22108803_ChIP-Seq_LS180_Human1.25219427
91GBX2_23144817_ChIP-Seq_PC3_Human1.24855823
92* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23257951
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22595247
94ELK4_26923725_Chip-Seq_MESODERM_Mouse1.21157929
95IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20739309
96VDR_24763502_ChIP-Seq_THP-1_Human1.19812425
97FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19464126
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19351570
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19140539
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19140539
101GATA3_27048872_Chip-Seq_THYMUS_Human1.19076383
102* NFE2_27457419_Chip-Seq_LIVER_Mouse1.18645583
103RXR_22108803_ChIP-Seq_LS180_Human1.18005811
104CDX2_22108803_ChIP-Seq_LS180_Human1.17403407
105AR_25329375_ChIP-Seq_VCAP_Human1.16961372
106* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.16664342
107SMRT_27268052_Chip-Seq_Bcells_Human1.16016524
108* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15021385
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14756204
110TCF4_23295773_ChIP-Seq_U87_Human1.13741649
111RUNX1_27514584_Chip-Seq_MCF-7_Human1.11168423
112UTX_26944678_Chip-Seq_JUKART_Human1.11112770
113CIITA_25753668_ChIP-Seq_RAJI_Human1.10729389
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09920869
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09007995
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08968673
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08744926
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07996452
119EZH2_22144423_ChIP-Seq_EOC_Human1.07840488
120* GATA4_25053715_ChIP-Seq_YYC3_Human1.07218959
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06126818
122GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.05621381
123SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05187116
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05146458
125HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03582074
126* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03094851
127STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03024570
128* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02520782
129FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01186241
130NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00967921
131* EZH2_27294783_Chip-Seq_NPCs_Mouse1.00617654
132FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00450342
133EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00406559
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00351756
135OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99522853
136* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99379834
137* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99028176
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98636880
139* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98268253
140* GATA3_26560356_Chip-Seq_TH1_Human0.98057656
141GATA3_21878914_ChIP-Seq_MCF-7_Human0.97682652
142KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97650964
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96763590
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96584172
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96341715
146FOXA1_25329375_ChIP-Seq_VCAP_Human0.96308180
147FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96308180
148RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96282228
149* OCT4_18555785_Chip-Seq_ESCs_Mouse0.95651439
150TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94826828
151* CRX_20693478_ChIP-Seq_RETINA_Mouse0.93642374
152* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93479212
153TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93458495
154SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92780874
155KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91954214
156ERG_20517297_ChIP-Seq_VCAP_Human0.89896795
157PRDM14_20953172_ChIP-Seq_ESCs_Human0.88883544
158DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88565241
159FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88414884
160PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88052292
161SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87458905
162TP53_16413492_ChIP-PET_HCT116_Human0.87372750
163MYC_27129775_Chip-Seq_CORNEA_Mouse0.86994777
164ZNF274_21170338_ChIP-Seq_K562_Hela0.86431274
165GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86109508
166DROSHA_22980978_ChIP-Seq_HELA_Human0.85805194
167KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85355761
168SPI1_23127762_ChIP-Seq_K562_Human0.85142380
169TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84658354
170CBP_20019798_ChIP-Seq_JUKART_Human0.83229694
171IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83229694
172EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.82863179
173BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82669316
174EGR1_19032775_ChIP-ChIP_M12_Human0.82354946
175SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81374427
176MYC_18940864_ChIP-ChIP_HL60_Human0.81161581
177EWS_26573619_Chip-Seq_HEK293_Human0.80513621
178FUS_26573619_Chip-Seq_HEK293_Human0.79808506

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol4.76874448
2MP0008004_abnormal_stomach_pH4.66413739
3* MP0002148_abnormal_hypersensitivity_rea4.65021980
4MP0010386_abnormal_urinary_bladder3.64712711
5MP0005423_abnormal_somatic_nervous3.53609932
6MP0001835_abnormal_antigen_presentation3.40117004
7MP0008057_abnormal_DNA_replication3.39563177
8MP0000490_abnormal_crypts_of3.34788488
9MP0001800_abnormal_humoral_immune3.11990419
10MP0001790_abnormal_immune_system2.80530343
11MP0005387_immune_system_phenotype2.80530343
12MP0005000_abnormal_immune_tolerance2.75912660
13MP0010155_abnormal_intestine_physiology2.44373509
14MP0003693_abnormal_embryo_hatching2.23039988
15MP0002452_abnormal_antigen_presenting2.20935466
16MP0000013_abnormal_adipose_tissue2.19813714
17MP0002736_abnormal_nociception_after2.10509124
18MP0000372_irregular_coat_pigmentation2.09386995
19MP0002102_abnormal_ear_morphology2.02797619
20MP0003436_decreased_susceptibility_to2.01756438
21MP0001986_abnormal_taste_sensitivity11.0911547
22MP0005671_abnormal_response_to1.94357128
23MP0000685_abnormal_immune_system1.83699083
24MP0002735_abnormal_chemical_nociception1.82755231
25MP0003718_maternal_effect1.81675785
26MP0000015_abnormal_ear_pigmentation1.80645481
27* MP0002420_abnormal_adaptive_immunity1.77971499
28MP0001348_abnormal_lacrimal_gland1.77897711
29MP0002405_respiratory_system_inflammati1.77714959
30MP0002723_abnormal_immune_serum1.77614479
31* MP0001819_abnormal_immune_cell1.74489218
32MP0001666_abnormal_nutrient_absorption1.67864040
33MP0005023_abnormal_wound_healing1.65313953
34MP0003303_peritoneal_inflammation1.63113855
35MP0005395_other_phenotype1.60298917
36MP0005360_urolithiasis1.59950023
37MP0005464_abnormal_platelet_physiology1.50330410
38MP0001968_abnormal_touch/_nociception1.49874248
39MP0002398_abnormal_bone_marrow1.49533742
40MP0009046_muscle_twitch1.47016712
41MP0002168_other_aberrant_phenotype1.43033320
42MP0002837_dystrophic_cardiac_calcinosis1.41949601
43MP0005551_abnormal_eye_electrophysiolog1.41878779
44MP0002909_abnormal_adrenal_gland1.39637852
45MP0006276_abnormal_autonomic_nervous1.38152532
46MP0000716_abnormal_immune_system1.37232775
47MP0000538_abnormal_urinary_bladder1.36141795
48MP0001845_abnormal_inflammatory_respons1.34288777
49MP0003300_gastrointestinal_ulcer1.33281233
50MP0008058_abnormal_DNA_repair1.31904330
51MP0004264_abnormal_extraembryonic_tissu1.30724889
52MP0002722_abnormal_immune_system1.29350634
53MP0000477_abnormal_intestine_morphology1.27236461
54MP0005075_abnormal_melanosome_morpholog1.25937817
55MP0002138_abnormal_hepatobiliary_system1.25886593
56MP0003638_abnormal_response/metabolism_1.25319492
57MP0003786_premature_aging1.24521601
58MP0008872_abnormal_physiological_respon1.18814436
59MP0003950_abnormal_plasma_membrane1.18072629
60MP0001346_abnormal_lacrimal_gland1.17035782
61MP0004858_abnormal_nervous_system1.15677158
62MP0005379_endocrine/exocrine_gland_phen1.14088420
63MP0000689_abnormal_spleen_morphology1.13230511
64MP0008995_early_reproductive_senescence1.12359635
65MP0004742_abnormal_vestibular_system1.12117596
66MP0005310_abnormal_salivary_gland1.11905959
67MP0005025_abnormal_response_to1.11205146
68MP0003252_abnormal_bile_duct1.08661812
69MP0004036_abnormal_muscle_relaxation1.08590224
70MP0002429_abnormal_blood_cell1.04515442
71MP0006036_abnormal_mitochondrial_physio1.03087926
72MP0009765_abnormal_xenobiotic_induced1.01653730
73MP0003787_abnormal_imprinting1.00428105
74MP0003866_abnormal_defecation1.00021777
75MP0010352_gastrointestinal_tract_polyps0.98777672
76MP0001664_abnormal_digestion0.97602668
77MP0002933_joint_inflammation0.97313686
78MP0008874_decreased_physiological_sensi0.94370705
79MP0010094_abnormal_chromosome_stability0.92498153
80MP0005253_abnormal_eye_physiology0.91301075
81MP0009763_increased_sensitivity_to0.91180202
82MP0005220_abnormal_exocrine_pancreas0.89267437
83MP0003221_abnormal_cardiomyocyte_apopto0.87168203
84MP0002419_abnormal_innate_immunity0.86618733
85MP0003077_abnormal_cell_cycle0.86269506
86MP0003878_abnormal_ear_physiology0.86149654
87MP0005377_hearing/vestibular/ear_phenot0.86149654
88MP0002163_abnormal_gland_morphology0.86146165
89MP0006138_congestive_heart_failure0.85756721
90MP0000537_abnormal_urethra_morphology0.85741197
91MP0005174_abnormal_tail_pigmentation0.84828668
92MP0002876_abnormal_thyroid_physiology0.84771723
93MP0002254_reproductive_system_inflammat0.84589505
94MP0009745_abnormal_behavioral_response0.83462645
95MP0010234_abnormal_vibrissa_follicle0.83178939
96MP0002166_altered_tumor_susceptibility0.83062649
97MP0000631_abnormal_neuroendocrine_gland0.82672335
98MP0006072_abnormal_retinal_apoptosis0.82302731
99MP0006035_abnormal_mitochondrial_morpho0.82154720
100MP0002693_abnormal_pancreas_physiology0.79663190
101MP0003075_altered_response_to0.78416585
102MP0010329_abnormal_lipoprotein_level0.78233403
103MP0002295_abnormal_pulmonary_circulatio0.77884631
104MP0004957_abnormal_blastocyst_morpholog0.77857087
105MP0010678_abnormal_skin_adnexa0.77560492
106MP0002653_abnormal_ependyma_morphology0.76657688
107MP0008775_abnormal_heart_ventricle0.75357253
108MP0003763_abnormal_thymus_physiology0.75223557
109MP0000465_gastrointestinal_hemorrhage0.73531604
110MP0000427_abnormal_hair_cycle0.72994014
111MP0001905_abnormal_dopamine_level0.72774458
112MP0000383_abnormal_hair_follicle0.71682211
113MP0001533_abnormal_skeleton_physiology0.71361744
114MP0004510_myositis0.71253880
115MP0004084_abnormal_cardiac_muscle0.70486043
116MP0003880_abnormal_central_pattern0.70231246
117MP0008469_abnormal_protein_level0.68535888
118MP0009764_decreased_sensitivity_to0.66513836
119MP0002090_abnormal_vision0.66193232
120MP0003566_abnormal_cell_adhesion0.65612565
121MP0000026_abnormal_inner_ear0.65395010
122MP0005332_abnormal_amino_acid0.65350480
123MP0001970_abnormal_pain_threshold0.65178595
124MP0005166_decreased_susceptibility_to0.64376187
125MP0001929_abnormal_gametogenesis0.64016773
126MP0004924_abnormal_behavior0.63880987
127MP0005386_behavior/neurological_phenoty0.63880987
128MP0003111_abnormal_nucleus_morphology0.63420001
129MP0005266_abnormal_metabolism0.63067232
130MP0003868_abnormal_feces_composition0.62533831
131MP0001485_abnormal_pinna_reflex0.61758250
132MP0008260_abnormal_autophagy0.60987882
133MP0009643_abnormal_urine_homeostasis0.60748537
134MP0004859_abnormal_synaptic_plasticity0.59949349
135MP0002210_abnormal_sex_determination0.59512087
136MP0002095_abnormal_skin_pigmentation0.59452051
137MP0005085_abnormal_gallbladder_physiolo0.58527882
138MP0003195_calcinosis0.58036386
139MP0003172_abnormal_lysosome_physiology0.57976663
140MP0002136_abnormal_kidney_physiology0.57815391
141MP0001873_stomach_inflammation0.56974876
142MP0003091_abnormal_cell_migration0.56502893
143MP0001501_abnormal_sleep_pattern0.54935827
144MP0002928_abnormal_bile_duct0.54830456
145MP0002396_abnormal_hematopoietic_system0.54464378
146MP0002019_abnormal_tumor_incidence0.54117339
147MP0003879_abnormal_hair_cell0.54015567
148MP0004484_altered_response_of0.53251390
149MP0002128_abnormal_blood_circulation0.53195032
150MP0001191_abnormal_skin_condition0.52769768
151MP0008877_abnormal_DNA_methylation0.51981509
152MP0001177_atelectasis0.51553094
153MP0000703_abnormal_thymus_morphology0.50366657
154MP0004947_skin_inflammation0.49960944

Predicted human phenotypes

RankGene SetZ-score
1Chronic sinusitis (HP:0011109)7.56631899
2Agammaglobulinemia (HP:0004432)7.19934975
3Gastrointestinal stroma tumor (HP:0100723)6.93781917
4Recurrent bronchitis (HP:0002837)6.55440147
511 pairs of ribs (HP:0000878)5.85769786
6Right ventricular cardiomyopathy (HP:0011663)4.81563242
7True hermaphroditism (HP:0010459)4.52017085
8IgA deficiency (HP:0002720)4.39856613
9Abnormal sex determination (HP:0012244)4.30033281
10Sex reversal (HP:0012245)4.30033281
11Cellulitis (HP:0100658)4.29617962
12Autoimmune thrombocytopenia (HP:0001973)4.28944722
13Recurrent sinusitis (HP:0011108)4.25727746
14Aplasia/Hypoplasia of the sternum (HP:0006714)4.18738297
15Neonatal short-limb short stature (HP:0008921)4.11094960
16Recurrent gram-negative bacterial infections (HP:0005420)3.88206614
17Abnormality of cells of the lymphoid lineage (HP:0012140)3.79799227
18Recurrent lower respiratory tract infections (HP:0002783)3.76834278
19Bronchitis (HP:0012387)3.76514590
20Limb hypertonia (HP:0002509)3.73103213
21Vascular calcification (HP:0004934)3.65402081
22Emphysema (HP:0002097)3.57235312
23Interstitial pulmonary disease (HP:0006530)3.51576622
24Lymphopenia (HP:0001888)3.51042483
25Colitis (HP:0002583)3.46036789
26Gait imbalance (HP:0002141)3.45656679
27Micronodular cirrhosis (HP:0001413)3.44880567
28Bronchomalacia (HP:0002780)3.41660737
29Mitral stenosis (HP:0001718)3.39131291
30Congenital primary aphakia (HP:0007707)3.31225528
31Cardiovascular calcification (HP:0011915)3.29568009
32Papilloma (HP:0012740)3.27621449
33Verrucae (HP:0200043)3.27621449
34Congenital stationary night blindness (HP:0007642)3.23093517
35Abnormal delayed hypersensitivity skin test (HP:0002963)3.17923731
36Pancreatic cysts (HP:0001737)3.15130472
37Restrictive lung disease (HP:0002091)3.12168333
38Missing ribs (HP:0000921)3.10990240
39Albinism (HP:0001022)3.03152726
40Hypokinesia (HP:0002375)3.03122081
41IgG deficiency (HP:0004315)3.02950602
42Chronic hepatic failure (HP:0100626)3.01170179
43Respiratory distress (HP:0002098)2.97664960
44IgM deficiency (HP:0002850)2.93761886
45Vertebral hypoplasia (HP:0008417)2.92222095
46Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.92222095
47Vasculitis (HP:0002633)2.89925635
48Recurrent pneumonia (HP:0006532)2.87197793
49Nephrogenic diabetes insipidus (HP:0009806)2.86011241
50Abnormality of the prostate (HP:0008775)2.74333401
51Abnormality of macular pigmentation (HP:0008002)2.73868543
52Leukopenia (HP:0001882)2.70817534
53Keratoconjunctivitis (HP:0001096)2.65699995
54Tibial bowing (HP:0002982)2.63516513
55Renal cortical cysts (HP:0000803)2.61065883
56Medial flaring of the eyebrow (HP:0010747)2.58505677
57Abnormal vertebral ossification (HP:0100569)2.55524533
58Poor coordination (HP:0002370)2.54425652
59Abnormality of the renal cortex (HP:0011035)2.53379461
60Viral hepatitis (HP:0006562)2.52121752
61Pancreatic fibrosis (HP:0100732)2.51987566
62Alveolar cell carcinoma (HP:0006519)2.50890355
63Meningitis (HP:0001287)2.48209817
64Abnormality of chromosome stability (HP:0003220)2.46879383
65Vaginal atresia (HP:0000148)2.46169893
66Neoplasm of the tracheobronchial system (HP:0100552)2.44717410
67Decreased central vision (HP:0007663)2.42882907
68Glossoptosis (HP:0000162)2.42403853
69Genital tract atresia (HP:0001827)2.41806099
70Nonimmune hydrops fetalis (HP:0001790)2.38412932
71Attenuation of retinal blood vessels (HP:0007843)2.38393830
72Esophageal varix (HP:0002040)2.36929927
73Sloping forehead (HP:0000340)2.36319759
74Keratoconjunctivitis sicca (HP:0001097)2.35807187
75Inflammation of the large intestine (HP:0002037)2.34333764
76Chronic otitis media (HP:0000389)2.31267788
77Fibular hypoplasia (HP:0003038)2.31248873
78Curly hair (HP:0002212)2.30768767
79Osteomyelitis (HP:0002754)2.29844389
80Aplasia/Hypoplasia of the uvula (HP:0010293)2.25411869
81Hypoplasia of the pons (HP:0012110)2.23366200
82Sepsis (HP:0100806)2.23216456
83Severe visual impairment (HP:0001141)2.23018384
84Abnormal rod and cone electroretinograms (HP:0008323)2.22895817
85Aplasia/Hypoplasia of the scapulae (HP:0006713)2.21314271
86Hypoplastic scapulae (HP:0000882)2.21314271
87Molar tooth sign on MRI (HP:0002419)2.21253339
88Abnormality of midbrain morphology (HP:0002418)2.21253339
89Central scotoma (HP:0000603)2.20162349
90Hepatoblastoma (HP:0002884)2.20121924
91Hypoplasia of the thymus (HP:0000778)2.18877143
92Abnormality of B cell number (HP:0010975)2.18592465
93Recurrent otitis media (HP:0000403)2.18492292
94Gaze-evoked nystagmus (HP:0000640)2.17786580
95Bundle branch block (HP:0011710)2.14324372
96Azoospermia (HP:0000027)2.12543220
97Gastrointestinal inflammation (HP:0004386)2.11604049
98Abnormality of the pons (HP:0007361)2.11463086
99Aplasia/Hypoplasia of the patella (HP:0006498)2.11368861
100Chromsome breakage (HP:0040012)2.10412290
101Prolonged QT interval (HP:0001657)2.10348799
102Broad foot (HP:0001769)2.09961293
103Hyperventilation (HP:0002883)2.09605010
104Autoimmune hemolytic anemia (HP:0001890)2.09238864
105Abnormality of T cell physiology (HP:0011840)2.07344922
106Clubbing of toes (HP:0100760)2.06160357
107Abnormality of the right ventricle (HP:0001707)2.04984734
108Spinal muscular atrophy (HP:0007269)2.03186394
109Distal lower limb muscle weakness (HP:0009053)2.03022260
110Nephronophthisis (HP:0000090)2.00445933
111Abnormality of carpal bone ossification (HP:0006257)2.00216807
112Carpal bone hypoplasia (HP:0001498)1.99947343
113Congenital sensorineural hearing impairment (HP:0008527)1.99065236
114Chronic diarrhea (HP:0002028)1.98630569
115Ketoacidosis (HP:0001993)1.97895111
116Partial agenesis of the corpus callosum (HP:0001338)1.97089338
117Recurrent viral infections (HP:0004429)1.96190001
118Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96075598
119Hypothermia (HP:0002045)1.95528018
120Progressive microcephaly (HP:0000253)1.95058849
121Abnormality of the renal medulla (HP:0100957)1.95030169
122Lymphoma (HP:0002665)1.93845649
123Protruding tongue (HP:0010808)1.91425704
124Progressive inability to walk (HP:0002505)1.90619070
125Stomach cancer (HP:0012126)1.90225879
126Abnormality of the intervertebral disk (HP:0005108)1.90218756
127Thyroiditis (HP:0100646)1.90033222
128Recurrent cutaneous fungal infections (HP:0011370)1.89970112
129Chronic mucocutaneous candidiasis (HP:0002728)1.89970112
130Epiphyseal dysplasia (HP:0002656)1.89556585
131Hyperglycinuria (HP:0003108)1.88260773
132Polydipsia (HP:0001959)1.87756533
133Abnormal drinking behavior (HP:0030082)1.87756533
134Prominent nose (HP:0000448)1.87399301
135Hyperammonemia (HP:0001987)1.86181659
136Panhypogammaglobulinemia (HP:0003139)1.85807462
137Recurrent abscess formation (HP:0002722)1.84976612
138Abnormality of the ileum (HP:0001549)1.84762504
139Coxa valga (HP:0002673)1.83429897
140Cone-rod dystrophy (HP:0000548)1.80812322
141Abnormal spermatogenesis (HP:0008669)1.80691020
142Rhabdomyosarcoma (HP:0002859)1.80654387
143Meckel diverticulum (HP:0002245)1.80159310
144Glucose intolerance (HP:0000833)1.79715238
145Potter facies (HP:0002009)1.79576890
146Facial shape deformation (HP:0011334)1.79576890
147Aplasia/Hypoplasia of the spleen (HP:0010451)1.79477492
148Keratitis (HP:0000491)1.79372648
149B lymphocytopenia (HP:0010976)1.78710043
150Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78224834
151Scanning speech (HP:0002168)1.78101628
152Tubular atrophy (HP:0000092)1.77965468
153Mediastinal lymphadenopathy (HP:0100721)1.77753491
154Intellectual disability, progressive (HP:0006887)1.77662667
155Duodenal stenosis (HP:0100867)1.77508475
156Small intestinal stenosis (HP:0012848)1.77508475
157Abnormality of renal resorption (HP:0011038)1.77385842
158Abnormality of the preputium (HP:0100587)1.77350240
159Petechiae (HP:0000967)1.77325577
160Cutaneous melanoma (HP:0012056)1.77235362
161Progressive neurologic deterioration (HP:0002344)1.76599475
162Neutropenia (HP:0001875)1.74750039
163Focal motor seizures (HP:0011153)1.73649083
164Abnormality of male internal genitalia (HP:0000022)1.73619648
165Ventricular arrhythmia (HP:0004308)1.73357109
166Opisthotonus (HP:0002179)1.72948318
167Small hand (HP:0200055)1.71083043
168Short clavicles (HP:0000894)1.70372126
169Type I transferrin isoform profile (HP:0003642)1.70197264
170Asplenia (HP:0001746)1.69870798
171Abnormality of the fetal cardiovascular system (HP:0010948)1.69753994
172Single umbilical artery (HP:0001195)1.69753994
173Inability to walk (HP:0002540)1.69600606
174Prostate neoplasm (HP:0100787)1.69460658
175Intestinal atresia (HP:0011100)1.66544122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB36.15036493
2MAPKAPK54.50823876
3MKNK13.94742605
4NME13.88146101
5TRPM73.05951301
6KSR22.99625245
7RAF12.76514593
8TEC2.42730778
9PRKCH2.41792277
10BMPR22.37253829
11KSR12.32772819
12MAP4K12.28025936
13SYK2.23472586
14DMPK2.22294272
15BMPR1B2.19968906
16EPHA42.17056687
17PRKCQ2.12886380
18BTK2.12868615
19RPS6KB22.07199527
20BCR2.01112694
21IRAK41.99335682
22BLK1.98556805
23CSF1R1.94855603
24STK391.87605378
25PRKCI1.85666374
26MAP3K101.82190732
27TRIM281.77480878
28ACVR1B1.77314681
29BUB11.71004860
30ITK1.68080409
31FRK1.59159978
32BRSK21.54504183
33PAK31.45800201
34RPS6KA41.41049461
35RPS6KA51.38087380
36MKNK21.36098926
37JAK31.35002377
38IRAK21.33368612
39AKT31.31350948
40CAMKK21.30723430
41CSNK1A1L1.29675169
42PAK61.28206723
43MAP2K11.26002568
44RIPK41.24240859
45CSNK1G31.23406608
46LYN1.22085517
47MST41.22063337
48ADRBK21.15271038
49OXSR11.11457308
50HCK1.07182408
51MAPKAPK21.07005122
52PLK41.03988192
53NEK91.03284263
54PIK3CG1.02364711
55CDK31.02138214
56ZAK0.99964322
57INSRR0.98156188
58GRK10.97666022
59TLK10.97565553
60MAPK110.96781786
61KIT0.94453966
62PRKCD0.89523104
63TYK20.88833106
64PKN20.88559560
65CSNK1G10.87082344
66MAP4K20.86432911
67CSNK1G20.85046281
68TBK10.81721616
69MAPK130.80197219
70TTK0.79809550
71CDC42BPA0.79294332
72TAOK30.77298460
73WEE10.75416136
74ATR0.75240491
75GRK60.74167413
76PNCK0.73992872
77ERN10.73602534
78PRKCE0.73333420
79ARAF0.72452560
80SRPK10.69942253
81FGFR20.64153499
82WNK30.63041004
83FLT30.62575812
84PRKCG0.62012341
85TNK20.61752570
86PRKCZ0.58741240
87PDK20.57267237
88CSK0.56840507
89MAP3K40.55263204
90CAMK2A0.54416805
91PASK0.54302400
92CLK10.54212027
93MATK0.53459039
94RPS6KA20.52920143
95WNK40.52808185
96CDK40.52270818
97PTK20.49752929
98PINK10.48421362
99MAPK70.48028543
100BRSK10.46927898
101IKBKE0.44799222
102CAMK2B0.43565840
103MAPK40.42751924
104STK30.41611658
105CDC70.41510113
106TAF10.40041867
107NUAK10.39047986
108EIF2AK20.39042270
109MAP3K140.38797174
110VRK10.35605687
111MAP3K90.35432044
112CHUK0.34810748
113CSNK1A10.34452844
114SIK30.30569097
115ABL10.30449115
116ATM0.30266266
117EIF2AK30.29510241
118LRRK20.29440038
119LCK0.28683191
120PLK20.28542393
121EGFR0.28490623
122BRAF0.28148286
123FYN0.27210874
124RPS6KL10.26968755
125RPS6KC10.26968755
126PRKACB0.26278577
127FER0.26251490
128CAMKK10.26120164
129RPS6KA60.25695393
130IGF1R0.25433514
131IKBKB0.24356406
132PDK10.24350577
133PRKCA0.23823315
134CAMK10.23427824
135MAP3K20.23311560
136ADRBK10.22976004
137NTRK30.22945544
138CAMK2G0.22839029
139BCKDK0.22656841
140CHEK10.22517756
141STK100.21785519
142CSNK1D0.21720312
143STK240.21397528
144PRKACG0.21178838
145STK40.20957758
146CCNB10.20403012
147IRAK10.19940900
148CAMK2D0.19191726
149RPS6KA10.18427016
150PIM20.16925173
151INSR0.16662857
152SRC0.16394398
153SGK20.16234911

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.10087176
2B cell receptor signaling pathway_Homo sapiens_hsa046624.37676303
3Base excision repair_Homo sapiens_hsa034103.34864109
4Asthma_Homo sapiens_hsa053103.29812773
5Carbohydrate digestion and absorption_Homo sapiens_hsa049732.98841307
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.94745324
7Linoleic acid metabolism_Homo sapiens_hsa005912.90498988
8Arachidonic acid metabolism_Homo sapiens_hsa005902.84485249
9Taste transduction_Homo sapiens_hsa047422.80496976
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.78502033
11Choline metabolism in cancer_Homo sapiens_hsa052312.65697979
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.61188299
13Mismatch repair_Homo sapiens_hsa034302.57908388
14Fanconi anemia pathway_Homo sapiens_hsa034602.42999742
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.42778996
16DNA replication_Homo sapiens_hsa030302.42308727
17Autoimmune thyroid disease_Homo sapiens_hsa053202.33191523
18Protein export_Homo sapiens_hsa030602.17026030
19Non-homologous end-joining_Homo sapiens_hsa034502.11428032
20Phototransduction_Homo sapiens_hsa047442.11046289
21Butanoate metabolism_Homo sapiens_hsa006501.82587231
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.77148577
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69728047
24Ether lipid metabolism_Homo sapiens_hsa005651.68858263
25Glycerolipid metabolism_Homo sapiens_hsa005611.64165992
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63245438
27Phospholipase D signaling pathway_Homo sapiens_hsa040721.56903518
28Basal transcription factors_Homo sapiens_hsa030221.56618355
29Serotonergic synapse_Homo sapiens_hsa047261.54254856
30VEGF signaling pathway_Homo sapiens_hsa043701.48544722
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44305844
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.43654138
33Leishmaniasis_Homo sapiens_hsa051401.40831988
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.39032922
35Long-term depression_Homo sapiens_hsa047301.37333939
36RNA degradation_Homo sapiens_hsa030181.37228604
37Homologous recombination_Homo sapiens_hsa034401.33657608
38Olfactory transduction_Homo sapiens_hsa047401.26946188
39Platelet activation_Homo sapiens_hsa046111.25042408
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21249765
41Viral myocarditis_Homo sapiens_hsa054161.17845099
42Caffeine metabolism_Homo sapiens_hsa002321.16303876
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.16165134
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11774183
45RNA polymerase_Homo sapiens_hsa030201.11377912
46Dorso-ventral axis formation_Homo sapiens_hsa043201.11353943
47Ovarian steroidogenesis_Homo sapiens_hsa049131.10936604
48Toxoplasmosis_Homo sapiens_hsa051451.07730628
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07326148
50One carbon pool by folate_Homo sapiens_hsa006701.06939523
51Propanoate metabolism_Homo sapiens_hsa006401.01863638
52Fatty acid degradation_Homo sapiens_hsa000710.99487017
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99191574
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96311663
55Sphingolipid metabolism_Homo sapiens_hsa006000.94732074
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.93466861
57Regulation of autophagy_Homo sapiens_hsa041400.92509444
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92132956
59Pancreatic cancer_Homo sapiens_hsa052120.88788297
60Non-small cell lung cancer_Homo sapiens_hsa052230.85938110
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85043485
62Pyrimidine metabolism_Homo sapiens_hsa002400.84016069
63Colorectal cancer_Homo sapiens_hsa052100.82787418
64Tuberculosis_Homo sapiens_hsa051520.81265922
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80012821
66GnRH signaling pathway_Homo sapiens_hsa049120.80005678
67Selenocompound metabolism_Homo sapiens_hsa004500.79576605
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78973862
69Shigellosis_Homo sapiens_hsa051310.73161741
70Hepatitis B_Homo sapiens_hsa051610.72096971
71Fat digestion and absorption_Homo sapiens_hsa049750.71404439
72T cell receptor signaling pathway_Homo sapiens_hsa046600.70160638
73Calcium signaling pathway_Homo sapiens_hsa040200.69417264
74Staphylococcus aureus infection_Homo sapiens_hsa051500.69205866
75Proteasome_Homo sapiens_hsa030500.68988476
76Antigen processing and presentation_Homo sapiens_hsa046120.68218999
77ABC transporters_Homo sapiens_hsa020100.67987726
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67938149
79Allograft rejection_Homo sapiens_hsa053300.67151262
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66371816
81Type I diabetes mellitus_Homo sapiens_hsa049400.65303267
82Measles_Homo sapiens_hsa051620.63706291
83Osteoclast differentiation_Homo sapiens_hsa043800.62975896
84Hematopoietic cell lineage_Homo sapiens_hsa046400.62572709
85Herpes simplex infection_Homo sapiens_hsa051680.61972655
86Purine metabolism_Homo sapiens_hsa002300.61443261
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60629315
88MAPK signaling pathway_Homo sapiens_hsa040100.59116307
89Chemokine signaling pathway_Homo sapiens_hsa040620.59007941
90Apoptosis_Homo sapiens_hsa042100.58494382
91PPAR signaling pathway_Homo sapiens_hsa033200.57823784
92Renal cell carcinoma_Homo sapiens_hsa052110.57766992
93Cholinergic synapse_Homo sapiens_hsa047250.56857828
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56407769
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.56400446
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.55593248
97Spliceosome_Homo sapiens_hsa030400.54352059
98Rheumatoid arthritis_Homo sapiens_hsa053230.53352104
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52497668
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.52161235
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52029736
102African trypanosomiasis_Homo sapiens_hsa051430.51112148
103mRNA surveillance pathway_Homo sapiens_hsa030150.50264382
104Lysine degradation_Homo sapiens_hsa003100.50111394
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48868074
106Endometrial cancer_Homo sapiens_hsa052130.48484587
107Influenza A_Homo sapiens_hsa051640.48236448
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47309088
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.46381319
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45366181
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45186797
112Sulfur metabolism_Homo sapiens_hsa009200.43753828
113RNA transport_Homo sapiens_hsa030130.42615810
114p53 signaling pathway_Homo sapiens_hsa041150.42426129
115Inositol phosphate metabolism_Homo sapiens_hsa005620.41424107
116Long-term potentiation_Homo sapiens_hsa047200.40487463
117Graft-versus-host disease_Homo sapiens_hsa053320.40358992
118Chronic myeloid leukemia_Homo sapiens_hsa052200.40341130
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.38463389
120Tryptophan metabolism_Homo sapiens_hsa003800.38263149
121Renin-angiotensin system_Homo sapiens_hsa046140.37722582
122Systemic lupus erythematosus_Homo sapiens_hsa053220.37255478
123Hepatitis C_Homo sapiens_hsa051600.37113540
124Pancreatic secretion_Homo sapiens_hsa049720.37058375
125Acute myeloid leukemia_Homo sapiens_hsa052210.36614588
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36054685
127Peroxisome_Homo sapiens_hsa041460.36043757
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35550218
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.35331705
130ErbB signaling pathway_Homo sapiens_hsa040120.35292107
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34419420
132Glioma_Homo sapiens_hsa052140.33620827
133Insulin resistance_Homo sapiens_hsa049310.33070211
134Alzheimers disease_Homo sapiens_hsa050100.32865789
135Glutamatergic synapse_Homo sapiens_hsa047240.32826580
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32686263
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31993711
138Proteoglycans in cancer_Homo sapiens_hsa052050.31498657
139Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30787408
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30328874
141Oxytocin signaling pathway_Homo sapiens_hsa049210.29638702
142Salmonella infection_Homo sapiens_hsa051320.29056195
143Type II diabetes mellitus_Homo sapiens_hsa049300.28846000
144Gap junction_Homo sapiens_hsa045400.27453864
145Salivary secretion_Homo sapiens_hsa049700.26613432
146Morphine addiction_Homo sapiens_hsa050320.26469482
147Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26203491
148Dopaminergic synapse_Homo sapiens_hsa047280.25259791
149Insulin secretion_Homo sapiens_hsa049110.25084082
150Nitrogen metabolism_Homo sapiens_hsa009100.24848070
151Ras signaling pathway_Homo sapiens_hsa040140.24682628
152Epstein-Barr virus infection_Homo sapiens_hsa051690.24610682
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23960696
154Aldosterone synthesis and secretion_Homo sapiens_hsa049250.23911037
155Neurotrophin signaling pathway_Homo sapiens_hsa047220.22885788
156Nucleotide excision repair_Homo sapiens_hsa034200.22052734
157Vibrio cholerae infection_Homo sapiens_hsa051100.19665538
158Viral carcinogenesis_Homo sapiens_hsa052030.17980515
159Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.16421162

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