RGS14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.34788991
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.34788991
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.44714699
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.44714699
5modulation by symbiont of host immune response (GO:0052553)5.44714699
6positive regulation by symbiont of host defense response (GO:0052509)5.44714699
7modulation by symbiont of host defense response (GO:0052031)5.44714699
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.44714699
9positive regulation of gamma-delta T cell activation (GO:0046645)5.23722748
10detection of other organism (GO:0098543)5.18263226
11detection of bacterium (GO:0016045)5.17544869
12regulation of B cell receptor signaling pathway (GO:0050855)4.90824062
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.82299855
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.82299855
15antigen processing and presentation of endogenous antigen (GO:0019883)4.75069359
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.68642175
17negative T cell selection (GO:0043383)4.60596946
18negative thymic T cell selection (GO:0045060)4.54395345
19leukocyte aggregation (GO:0070486)4.46029207
20macrophage activation involved in immune response (GO:0002281)4.37217623
21response to peptidoglycan (GO:0032494)4.28848820
22mast cell activation (GO:0045576)4.20584142
23cellular response to interleukin-15 (GO:0071350)4.20441168
24detection of external biotic stimulus (GO:0098581)4.17926088
25response to interleukin-15 (GO:0070672)4.10787408
26mast cell degranulation (GO:0043303)4.10626003
27mast cell activation involved in immune response (GO:0002279)4.10626003
28regulation of gamma-delta T cell differentiation (GO:0045586)4.08336488
29regulation of interferon-beta biosynthetic process (GO:0045357)4.03734932
30B cell receptor signaling pathway (GO:0050853)4.00985687
31positive T cell selection (GO:0043368)3.94088787
32T cell selection (GO:0045058)3.93016364
33leukocyte migration involved in inflammatory response (GO:0002523)3.91621833
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.90021239
35G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.81932651
36negative regulation of interleukin-12 production (GO:0032695)3.80525313
37T cell migration (GO:0072678)3.79799632
38positive thymic T cell selection (GO:0045059)3.79152741
39regulation of gamma-delta T cell activation (GO:0046643)3.79097861
40response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.76534744
41response to host immune response (GO:0052572)3.76534744
42thymic T cell selection (GO:0045061)3.73057836
43negative regulation of phagocytosis (GO:0050765)3.70204030
44detection of biotic stimulus (GO:0009595)3.62214559
45positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.62171152
46negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.58280377
47regulation of mast cell degranulation (GO:0043304)3.57430140
48negative regulation of erythrocyte differentiation (GO:0045647)3.56429841
49regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.50048238
50detection of molecule of bacterial origin (GO:0032490)3.49656016
51response to muramyl dipeptide (GO:0032495)3.49402678
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.48522633
53response to host (GO:0075136)3.48522633
54response to host defenses (GO:0052200)3.48522633
55positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.46883087
56synaptic vesicle maturation (GO:0016188)3.44162005
57locomotory exploration behavior (GO:0035641)3.41297420
58regulation of myeloid leukocyte mediated immunity (GO:0002886)3.34056641
59positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.31311079
60regulation of tolerance induction (GO:0002643)3.30658704
61regulation of mast cell activation involved in immune response (GO:0033006)3.26773139
62positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.24470504
63negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.23580731
64signal complex assembly (GO:0007172)3.23387229
65microglial cell activation (GO:0001774)3.21369530
66B cell mediated immunity (GO:0019724)3.21369424
67antigen receptor-mediated signaling pathway (GO:0050851)3.20871108
68neutrophil mediated immunity (GO:0002446)3.20212030
69regulation of T cell mediated cytotoxicity (GO:0001914)3.19555389
70germinal center formation (GO:0002467)3.19418263
71regulation of leukocyte degranulation (GO:0043300)3.19396437
72positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16292786
73regulation of isotype switching to IgG isotypes (GO:0048302)3.15913662
74regulation of B cell differentiation (GO:0045577)3.14883788
75leukocyte degranulation (GO:0043299)3.13555214
76regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.13536505
77regulation of natural killer cell mediated immunity (GO:0002715)3.13536505
78production of molecular mediator involved in inflammatory response (GO:0002532)3.12743455
79activated T cell proliferation (GO:0050798)3.11945091
80T cell receptor signaling pathway (GO:0050852)3.10349895
81positive regulation of mast cell activation (GO:0033005)3.09979467
82regulation of short-term neuronal synaptic plasticity (GO:0048172)3.07326747
83myeloid cell activation involved in immune response (GO:0002275)3.07308059
84negative regulation of innate immune response (GO:0045824)3.06911182
85interferon-gamma-mediated signaling pathway (GO:0060333)3.06522518
86regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04493959
87macrophage activation (GO:0042116)3.03646137
88mature B cell differentiation (GO:0002335)3.03486560
89negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.03210042
90regulation of mast cell activation (GO:0033003)3.00758940
91cellular extravasation (GO:0045123)3.00164117
92regulation of Rap GTPase activity (GO:0032317)2.99188992
93positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.98788809
94positive regulation of granulocyte differentiation (GO:0030854)2.97593022
95T cell costimulation (GO:0031295)2.96089306
96interferon-gamma production (GO:0032609)2.95732918
97ionotropic glutamate receptor signaling pathway (GO:0035235)2.94096939
98positive regulation of Rap GTPase activity (GO:0032854)2.93744075
99negative regulation of interleukin-6 production (GO:0032715)2.92964758
100negative regulation of T-helper cell differentiation (GO:0045623)2.92890433
101negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92890433
102lymphocyte costimulation (GO:0031294)2.91687190
103regulation of glutamate receptor signaling pathway (GO:1900449)2.89893105
104negative regulation of T cell receptor signaling pathway (GO:0050860)2.89615033
105regulation of T cell receptor signaling pathway (GO:0050856)2.87235061
106respiratory burst (GO:0045730)2.86219199
107immune response-activating cell surface receptor signaling pathway (GO:0002429)2.84974997
108Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83717918
109negative regulation of lymphocyte mediated immunity (GO:0002707)2.83709520
110regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.83313094
111regulation of synapse structural plasticity (GO:0051823)2.82678698
112regulation of long-term neuronal synaptic plasticity (GO:0048169)2.82014237
113antigen processing and presentation via MHC class Ib (GO:0002475)2.81660583
114negative regulation of leukocyte mediated immunity (GO:0002704)2.80217841
115positive regulation of lamellipodium assembly (GO:0010592)2.79306908
116regulation of defense response to virus by virus (GO:0050690)2.78703521
117regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.77580554
118response to type I interferon (GO:0034340)2.75362170
119regulation of neuronal synaptic plasticity (GO:0048168)2.74753978
120type I interferon signaling pathway (GO:0060337)2.74576198
121cellular response to type I interferon (GO:0071357)2.74576198
122defense response to protozoan (GO:0042832)2.74112415
123immunoglobulin mediated immune response (GO:0016064)2.72812185
124negative regulation of T cell mediated immunity (GO:0002710)2.72294043
125regulation of alpha-beta T cell proliferation (GO:0046640)2.72210709
126positive regulation of interleukin-2 production (GO:0032743)2.71337272
127leukocyte cell-cell adhesion (GO:0007159)2.67353289
128neutrophil activation involved in immune response (GO:0002283)2.67245972
129regulation of regulatory T cell differentiation (GO:0045589)2.67148379
130tolerance induction (GO:0002507)2.66437600
131regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.64315792
132regulation of ARF protein signal transduction (GO:0032012)2.63216047
133positive regulation of B cell differentiation (GO:0045579)2.62905840
134synaptic vesicle exocytosis (GO:0016079)2.62901845
135response to protozoan (GO:0001562)2.60077704
136regulation of interleukin-2 biosynthetic process (GO:0045076)2.60055666
137exploration behavior (GO:0035640)2.59766447
138regulation of T-helper 1 cell differentiation (GO:0045625)2.58437775
139neutrophil activation (GO:0042119)2.58386319
140mature B cell differentiation involved in immune response (GO:0002313)2.55753196
141Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.55574979
142adenosine receptor signaling pathway (GO:0001973)2.53579095
143granulocyte activation (GO:0036230)2.52734419
144regulation of T cell tolerance induction (GO:0002664)2.52060664
145immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.51978485
146Fc-gamma receptor signaling pathway (GO:0038094)2.51978485
147Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.51978485
148positive regulation of alpha-beta T cell proliferation (GO:0046641)2.50821709
149lymphocyte migration (GO:0072676)2.49909779
150synaptic vesicle docking involved in exocytosis (GO:0016081)2.47718091
151angiogenesis involved in wound healing (GO:0060055)2.47538488
152negative regulation of interleukin-17 production (GO:0032700)2.46820368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.96348074
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.68351564
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.51174751
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.40129127
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.47257705
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.39948459
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.33944400
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.18781422
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.95521737
10RUNX_20019798_ChIP-Seq_JUKART_Human2.89891640
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.84815256
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.82436268
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77751590
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.68915386
15* MYC_22102868_ChIP-Seq_BL_Human2.64841164
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.56851611
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.53356003
18MYB_26560356_Chip-Seq_TH2_Human2.43551293
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40602298
20* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.40347341
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.37650542
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37430399
23VDR_21846776_ChIP-Seq_THP-1_Human2.36227446
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33768100
25MAF_26560356_Chip-Seq_TH1_Human2.31519815
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.30938414
27SPI1_23127762_ChIP-Seq_K562_Human2.23152128
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.17706429
29* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.10725465
30UTX_26944678_Chip-Seq_JUKART_Human2.05543659
31SCL_19346495_ChIP-Seq_HPC-7_Human2.03483459
32KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03209249
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02126120
34MYB_26560356_Chip-Seq_TH1_Human2.00816777
35TCF7_22412390_ChIP-Seq_EML_Mouse1.99700598
36VDR_24763502_ChIP-Seq_THP-1_Human1.98229082
37* RUNX1_22412390_ChIP-Seq_EML_Mouse1.87073002
38KDM2B_26808549_Chip-Seq_DND41_Human1.86960903
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81103536
40* SPI1_23547873_ChIP-Seq_NB4_Human1.80248803
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78576524
42EZH2_22144423_ChIP-Seq_EOC_Human1.71235746
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70964631
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.70466285
45GATA3_27048872_Chip-Seq_THYMUS_Human1.69473431
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69111968
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63252744
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61215532
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61064987
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56290866
51DROSHA_22980978_ChIP-Seq_HELA_Human1.52251030
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51950776
53MAF_26560356_Chip-Seq_TH2_Human1.46597885
54* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43523093
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39080192
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.38953920
57LXR_22292898_ChIP-Seq_THP-1_Human1.38542391
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.38514265
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36931918
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35058126
61* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34221097
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33949361
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29280086
64PU_27001747_Chip-Seq_BMDM_Mouse1.26132022
65* BCOR_27268052_Chip-Seq_Bcells_Human1.25611938
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.25573173
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25145413
68REST_21632747_ChIP-Seq_MESCs_Mouse1.24133536
69RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.23392238
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23213221
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21078448
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20903610
73GATA3_26560356_Chip-Seq_TH2_Human1.20623753
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.18333895
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17281855
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.15513165
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15402021
78* NCOR1_26117541_ChIP-Seq_K562_Human1.12363375
79CIITA_25753668_ChIP-Seq_RAJI_Human1.11958062
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11393264
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11110815
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.10295884
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09687037
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09006291
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07125662
86* ELK3_25401928_ChIP-Seq_HUVEC_Human1.06946642
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06923829
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06860823
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05022444
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03940798
91PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03585553
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03316380
93* P68_20966046_ChIP-Seq_HELA_Human1.02388409
94* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01305930
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99798753
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98440878
97VDR_24787735_ChIP-Seq_THP-1_Human0.97312688
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96991694
99* SPI1_20517297_ChIP-Seq_HL60_Human0.95278066
100* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92957200
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92898659
102SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92182585
103RACK7_27058665_Chip-Seq_MCF-7_Human0.90634747
104GATA1_19941826_ChIP-Seq_K562_Human0.89338624
105JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89189561
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86639357
107CTCF_21964334_ChIP-Seq_BJAB-B_Human0.86532478
108CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86431463
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86319174
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85908906
111* SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.85666966
112* BCL6_27268052_Chip-Seq_Bcells_Human0.85556388
113MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84738924
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84646887
115GATA2_19941826_ChIP-Seq_K562_Human0.84538321
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84508991
117* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84145470
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81731248
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81698580
120GATA1_22025678_ChIP-Seq_K562_Human0.79339786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004859_abnormal_synaptic_plasticity4.22754956
2MP0001835_abnormal_antigen_presentation3.56629159
3MP0002822_catalepsy3.14289250
4MP0005671_abnormal_response_to3.02230192
5MP0003303_peritoneal_inflammation2.91980839
6MP0000685_abnormal_immune_system2.88946409
7MP0001800_abnormal_humoral_immune2.69596643
8MP0003880_abnormal_central_pattern2.68475002
9MP0005000_abnormal_immune_tolerance2.67636687
10MP0005387_immune_system_phenotype2.65670161
11MP0001790_abnormal_immune_system2.65670161
12MP0003763_abnormal_thymus_physiology2.65142955
13MP0004510_myositis2.63781821
14MP0003436_decreased_susceptibility_to2.58982975
15MP0009785_altered_susceptibility_to2.58639547
16MP0002723_abnormal_immune_serum2.42600466
17MP0002420_abnormal_adaptive_immunity2.41756017
18MP0001819_abnormal_immune_cell2.39771139
19MP0002452_abnormal_antigen_presenting2.39626912
20MP0002148_abnormal_hypersensitivity_rea2.31650690
21* MP0003635_abnormal_synaptic_transmissio2.29009788
22MP0005025_abnormal_response_to2.28077904
23MP0002419_abnormal_innate_immunity2.25709133
24MP0002398_abnormal_bone_marrow2.13309554
25MP0003191_abnormal_cellular_cholesterol2.06296639
26MP0009745_abnormal_behavioral_response2.05445775
27MP0006082_CNS_inflammation2.01069417
28MP0002132_abnormal_respiratory_system1.97794892
29MP0000716_abnormal_immune_system1.96092173
30MP0005464_abnormal_platelet_physiology1.95417410
31MP0003075_altered_response_to1.92910235
32MP0008260_abnormal_autophagy1.91360593
33* MP0002063_abnormal_learning/memory/cond1.88117244
34MP0002064_seizures1.80299612
35MP0005451_abnormal_body_composition1.69768413
36MP0002006_tumorigenesis1.69292245
37MP0002405_respiratory_system_inflammati1.69055543
38MP0005310_abnormal_salivary_gland1.66809576
39MP0002166_altered_tumor_susceptibility1.65583260
40MP0000689_abnormal_spleen_morphology1.65185006
41MP0002722_abnormal_immune_system1.61232262
42MP0003172_abnormal_lysosome_physiology1.60191617
43MP0001501_abnormal_sleep_pattern1.59043249
44MP0002429_abnormal_blood_cell1.53682852
45MP0004947_skin_inflammation1.52617451
46MP0000703_abnormal_thymus_morphology1.50734079
47MP0003300_gastrointestinal_ulcer1.48810219
48MP0001873_stomach_inflammation1.48383764
49MP0010155_abnormal_intestine_physiology1.47897362
50MP0004381_abnormal_hair_follicle1.47700109
51MP0001845_abnormal_inflammatory_respons1.46109617
52MP0001968_abnormal_touch/_nociception1.43003463
53* MP0002572_abnormal_emotion/affect_behav1.38379307
54MP0004808_abnormal_hematopoietic_stem1.36682452
55MP0001853_heart_inflammation1.36611321
56MP0003866_abnormal_defecation1.36232342
57MP0009333_abnormal_splenocyte_physiolog1.35597291
58MP0003828_pulmonary_edema1.35561045
59MP0002736_abnormal_nociception_after1.33137215
60MP0005058_abnormal_lysosome_morphology1.31426588
61MP0003724_increased_susceptibility_to1.31101088
62MP0000604_amyloidosis1.30561498
63MP0003329_amyloid_beta_deposits1.29136548
64MP0005166_decreased_susceptibility_to1.24047482
65MP0002277_abnormal_respiratory_mucosa1.22907067
66MP0008569_lethality_at_weaning1.19509706
67MP0002396_abnormal_hematopoietic_system1.19485028
68MP0008874_decreased_physiological_sensi1.18547836
69MP0005174_abnormal_tail_pigmentation1.17360661
70MP0003183_abnormal_peptide_metabolism1.16817561
71MP0002735_abnormal_chemical_nociception1.16236106
72MP0001533_abnormal_skeleton_physiology1.15273450
73MP0004270_analgesia1.12970689
74MP0005397_hematopoietic_system_phenotyp1.12732315
75MP0001545_abnormal_hematopoietic_system1.12732315
76MP0005075_abnormal_melanosome_morpholog1.11098107
77MP0000569_abnormal_digit_pigmentation1.06616377
78MP0002138_abnormal_hepatobiliary_system1.04560021
79MP0002909_abnormal_adrenal_gland1.04027692
80MP0004883_abnormal_blood_vessel1.02754359
81MP0000490_abnormal_crypts_of1.01381830
82MP0008469_abnormal_protein_level1.01279027
83MP0009278_abnormal_bone_marrow0.98285862
84MP0009046_muscle_twitch0.98153675
85* MP0002272_abnormal_nervous_system0.97832724
86MP0008961_abnormal_basal_metabolism0.96689710
87MP0000015_abnormal_ear_pigmentation0.95555811
88MP0003633_abnormal_nervous_system0.94010865
89MP0003879_abnormal_hair_cell0.93289969
90MP0000465_gastrointestinal_hemorrhage0.91798282
91MP0001851_eye_inflammation0.90219526
92MP0003787_abnormal_imprinting0.90136570
93MP0002933_joint_inflammation0.89983011
94MP0001486_abnormal_startle_reflex0.88295748
95MP0001970_abnormal_pain_threshold0.87740433
96MP0001986_abnormal_taste_sensitivity0.87603227
97MP0000858_altered_metastatic_potential0.86957966
98MP0003690_abnormal_glial_cell0.86224658
99* MP0004811_abnormal_neuron_physiology0.86161822
100MP0005167_abnormal_blood-brain_barrier0.85806866
101MP0010234_abnormal_vibrissa_follicle0.84310699
102MP0003806_abnormal_nucleotide_metabolis0.84179403
103MP0009763_increased_sensitivity_to0.83429372
104MP0002009_preneoplasia0.83002999
105MP0009764_decreased_sensitivity_to0.82157485
106MP0001663_abnormal_digestive_system0.77979039
107MP0001905_abnormal_dopamine_level0.76457344
108MP0005390_skeleton_phenotype0.75776109
109MP0005535_abnormal_body_temperature0.75116358
110MP0001440_abnormal_grooming_behavior0.74441059
111MP0003448_altered_tumor_morphology0.74076007
112MP0003045_fibrosis0.73775308
113MP0002733_abnormal_thermal_nociception0.70918163
114MP0000920_abnormal_myelination0.70642934
115MP0005164_abnormal_response_to0.70195825
116MP0005386_behavior/neurological_phenoty0.68290975
117MP0004924_abnormal_behavior0.68290975
118MP0000343_altered_response_to0.67727366
119MP0002019_abnormal_tumor_incidence0.65970871
120MP0002998_abnormal_bone_remodeling0.65926803
121MP0005423_abnormal_somatic_nervous0.65673712
122MP0008004_abnormal_stomach_pH0.63878968
123MP0003656_abnormal_erythrocyte_physiolo0.61365035
124MP0009765_abnormal_xenobiotic_induced0.61093388
125MP0003795_abnormal_bone_structure0.58345680
126MP0002928_abnormal_bile_duct0.55652284
127MP0000609_abnormal_liver_physiology0.54640205
128MP0000249_abnormal_blood_vessel0.53530938
129MP0005319_abnormal_enzyme/_coenzyme0.53380444
130MP0002693_abnormal_pancreas_physiology0.50787313
131MP0005083_abnormal_biliary_tract0.47737461
132MP0009840_abnormal_foam_cell0.45963092
133MP0004130_abnormal_muscle_cell0.44971168
134MP0003252_abnormal_bile_duct0.42851695
135MP0009642_abnormal_blood_homeostasis0.42160974
136MP0003878_abnormal_ear_physiology0.41261935
137MP0005377_hearing/vestibular/ear_phenot0.41261935

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.87376885
2Eczematoid dermatitis (HP:0000976)4.63206472
3Recurrent bacterial skin infections (HP:0005406)4.24476308
4Chronic otitis media (HP:0000389)4.20652254
5Gastrointestinal infarctions (HP:0005244)4.19394594
6Recurrent fungal infections (HP:0002841)4.04357512
7T lymphocytopenia (HP:0005403)3.93223422
8Elevated erythrocyte sedimentation rate (HP:0003565)3.91634714
9Myokymia (HP:0002411)3.87448704
10Focal motor seizures (HP:0011153)3.87219140
11Recurrent viral infections (HP:0004429)3.87213021
12Abnormality of T cell number (HP:0011839)3.82972830
13Mediastinal lymphadenopathy (HP:0100721)3.82618919
14Stomatitis (HP:0010280)3.72243202
15Recurrent bronchitis (HP:0002837)3.69314226
16IgM deficiency (HP:0002850)3.66418574
17Hypochromic microcytic anemia (HP:0004840)3.62023039
18Myositis (HP:0100614)3.54024501
19Panhypogammaglobulinemia (HP:0003139)3.48682283
20Increased IgE level (HP:0003212)3.41698634
21Urticaria (HP:0001025)3.41390951
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.39423781
23Recurrent gram-negative bacterial infections (HP:0005420)3.32700222
24Hypochromic anemia (HP:0001931)3.31308499
25Chronic mucocutaneous candidiasis (HP:0002728)3.30780931
26Recurrent cutaneous fungal infections (HP:0011370)3.30780931
27Meningitis (HP:0001287)3.27606427
28Obstructive lung disease (HP:0006536)3.24837438
29Chronic obstructive pulmonary disease (HP:0006510)3.24837438
30Recurrent skin infections (HP:0001581)3.15572763
31Abnormality of T cells (HP:0002843)3.13094347
32Cellulitis (HP:0100658)3.12904313
33Nasal polyposis (HP:0100582)3.10500191
34Papilledema (HP:0001085)3.03570609
35Papilloma (HP:0012740)3.02361881
36Verrucae (HP:0200043)3.02361881
37Agammaglobulinemia (HP:0004432)3.02103178
38Pustule (HP:0200039)2.97510563
39Abnormality of macrophages (HP:0004311)2.92644876
40Autoimmune thrombocytopenia (HP:0001973)2.89850683
41Episodic fever (HP:0001954)2.88600792
42Vasculitis (HP:0002633)2.81256911
43Abnormality of the nasal mucosa (HP:0000433)2.77283877
44Visual hallucinations (HP:0002367)2.76174462
45Focal seizures (HP:0007359)2.76151000
46Lymphopenia (HP:0001888)2.75661950
47Gingival bleeding (HP:0000225)2.75329020
48Thyroiditis (HP:0100646)2.75176792
49Chronic sinusitis (HP:0011109)2.74045096
50Osteomyelitis (HP:0002754)2.72222470
51Inflammation of the large intestine (HP:0002037)2.71773253
52Gastrointestinal inflammation (HP:0004386)2.69115158
53Abnormality of B cell number (HP:0010975)2.67154866
54B lymphocytopenia (HP:0010976)2.67154866
55Abnormality of cells of the lymphoid lineage (HP:0012140)2.65359257
56Anorexia (HP:0002039)2.65152065
57Pulmonary embolism (HP:0002204)2.63802565
58IgG deficiency (HP:0004315)2.62110441
59Recurrent sinusitis (HP:0011108)2.55839975
60Sepsis (HP:0100806)2.55127134
61Colitis (HP:0002583)2.51072045
62Annular pancreas (HP:0001734)2.47533724
63Prolonged bleeding time (HP:0003010)2.46501076
64Gingivitis (HP:0000230)2.46298820
65Severe combined immunodeficiency (HP:0004430)2.43597400
66Microcytic anemia (HP:0001935)2.43410575
67Combined immunodeficiency (HP:0005387)2.42420212
68Hypergammaglobulinemia (HP:0010702)2.35633807
69Spontaneous hematomas (HP:0007420)2.33920688
70Optic neuritis (HP:0100653)2.33887015
71Retrobulbar optic neuritis (HP:0100654)2.33887015
72Supranuclear gaze palsy (HP:0000605)2.32420297
73Abnormality of binocular vision (HP:0011514)2.31994244
74Diplopia (HP:0000651)2.31994244
75Eosinophilia (HP:0001880)2.31795892
76Purpura (HP:0000979)2.29532682
77Orchitis (HP:0100796)2.25469802
78Petechiae (HP:0000967)2.24777351
79Gastrointestinal stroma tumor (HP:0100723)2.24329910
80Skin ulcer (HP:0200042)2.23843909
81Abnormality of T cell physiology (HP:0011840)2.22712360
82Pulmonary infiltrates (HP:0002113)2.21905237
83Gangrene (HP:0100758)2.20513514
84Abnormality of the pleura (HP:0002103)2.19712630
85Chest pain (HP:0100749)2.19182027
86Thrombocytosis (HP:0001894)2.18530146
87Leukocytosis (HP:0001974)2.18045387
88Atonic seizures (HP:0010819)2.17552819
89Amyloidosis (HP:0011034)2.16245890
90Abnormality of eosinophils (HP:0001879)2.14968922
91Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14368971
92Viral hepatitis (HP:0006562)2.13852520
93Recurrent pneumonia (HP:0006532)2.13306771
94Keratoconjunctivitis sicca (HP:0001097)2.13300650
95Acute hepatic failure (HP:0006554)2.13079398
96Encephalitis (HP:0002383)2.12238911
97Hepatosplenomegaly (HP:0001433)2.12129668
98Skin rash (HP:0000988)2.10058737
99Peritonitis (HP:0002586)2.09557182
100Hemoptysis (HP:0002105)2.09413535
101Diminished motivation (HP:0000745)2.09092512
102Premature loss of primary teeth (HP:0006323)2.08393616
103Absence seizures (HP:0002121)2.07927867
104Mutism (HP:0002300)2.07666968
105Increased IgM level (HP:0003496)2.05729061
106Loss of speech (HP:0002371)2.05653827
107Recurrent lower respiratory tract infections (HP:0002783)2.04711896
108Apathy (HP:0000741)2.04500073
109Increased serum ferritin (HP:0003281)2.03663053
110Febrile seizures (HP:0002373)2.03104104
111Stereotypic behavior (HP:0000733)2.02969694
112Slow saccadic eye movements (HP:0000514)2.02518462
113Granulocytopenia (HP:0001913)2.02270638
114Abnormality of the peritoneum (HP:0002585)2.01866087
115Increased cerebral lipofuscin (HP:0011813)2.01289650
116Epistaxis (HP:0000421)1.99653986
117Arterial thrombosis (HP:0004420)1.99520491
118Glomerulopathy (HP:0100820)1.99065415
119Periodontitis (HP:0000704)1.98437428
120Bronchitis (HP:0012387)1.96199140
121Dysostosis multiplex (HP:0000943)1.95738583
122Dialeptic seizures (HP:0011146)1.95658855
123Acne (HP:0001061)1.94648696
124Keratoconjunctivitis (HP:0001096)1.94548016
125Vacuolated lymphocytes (HP:0001922)1.94523160
126Basal cell carcinoma (HP:0002671)1.94507687
127Ocular albinism (HP:0001107)1.94398160
128Emphysema (HP:0002097)1.93800138
129Autoimmune hemolytic anemia (HP:0001890)1.93598325
130Abnormal platelet volume (HP:0011876)1.93527307
131Abnormality of iron homeostasis (HP:0011031)1.93295643
132Abnormality of the heme biosynthetic pathway (HP:0010472)1.92960082
133Hemiplegia (HP:0002301)1.92574428
134Hypertensive crisis (HP:0100735)1.92091176
135Joint swelling (HP:0001386)1.89377787

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.40028018
2MAP4K14.33532591
3MAP3K133.74828816
4EPHA43.73038755
5MAP3K92.88445908
6FES2.78492334
7MAP2K32.64543807
8TXK2.61182241
9GRK62.53171702
10NTRK32.23583409
11BLK2.20250476
12SIK22.18567222
13KSR22.06920767
14SYK2.02012490
15MAP3K121.91637564
16ZAP701.86827910
17ARAF1.84104906
18TYK21.70425950
19MAP3K111.67733730
20HCK1.65971505
21IKBKE1.63075862
22JAK31.62308644
23DAPK21.60817724
24DAPK11.56274745
25TAOK31.54747810
26JAK11.52258046
27MAP3K31.50922408
28ITK1.38866368
29KIT1.36995291
30CAMKK11.35906957
31IRAK41.35151995
32PRKCH1.34533967
33BTK1.33875786
34TESK21.32731769
35TBK11.32248719
36RAF11.31527621
37MAP3K141.27377446
38TNK21.23423411
39SMG11.20757907
40LCK1.20006939
41FGR1.18242676
42CSK1.15133994
43CLK11.09125432
44TEC1.07671613
45STK101.05824895
46PDK11.04671656
47CSF1R1.02054595
48MINK11.00725684
49BMPR21.00055358
50TAOK10.97657530
51LYN0.96021198
52PRKCQ0.94793888
53KSR10.94487650
54YES10.94479057
55PTK2B0.94239021
56SIK30.93752306
57ALK0.93199227
58PTK60.89243105
59TAOK20.88406097
60PKN20.84241354
61MAP3K70.82688538
62CDK50.80980390
63MAP3K10.78356989
64MARK30.76419266
65JAK20.76062584
66LRRK20.72952575
67CAMK10.71592553
68FYN0.70149617
69PRPF4B0.67943044
70FGFR30.66015491
71MATK0.64010729
72PAK60.63821630
73PDPK10.62604373
74SIK10.62238065
75MAPK70.61829933
76IRAK10.61640901
77IRAK20.61197972
78CAMKK20.59879083
79EEF2K0.59844354
80ERN10.59264565
81HIPK20.58374605
82TRIB30.57247644
83FGFR40.56677335
84PIM10.54806575
85NTRK20.54788362
86CDK190.53129590
87KDR0.52259190
88IKBKB0.51764221
89TYRO30.51692284
90DYRK1B0.51603563
91CDC42BPA0.51301041
92MAP3K40.51247588
93MAP3K60.50455401
94CDK40.48338941
95MAP2K70.48097402
96PRKD30.47831594
97PRKD20.47655084
98MOS0.47413566
99MARK20.46906219
100GRK50.46782063
101STK110.46706015
102SGK30.46301423
103MAP3K100.45337436
104NLK0.44292384
105RPS6KL10.44112014
106RPS6KC10.44112014
107CDK120.42921110
108MAP2K20.41635208
109SCYL20.40003695
110PLK20.39830192
111MAP3K50.38307957
112PIK3CG0.37856420
113MAPKAPK20.37780266
114RET0.37666815
115MAP3K80.37629256
116PASK0.36552557
117DAPK30.36443488
118MAPK110.35286501
119NTRK10.35130682
120MAPK120.34535082
121RPS6KA60.34465069
122PRKCG0.34423278
123MAP3K20.34265990
124PRKCD0.34104334
125STK380.32131090
126MAP2K60.31904935
127EPHB10.31193295
128CAMK40.30678262
129SGK10.29843887
130MAP2K40.27447838
131CAMK2B0.27359171
132EGFR0.25910383
133TNIK0.25630489
134TGFBR20.23470087

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.74494037
2Autoimmune thyroid disease_Homo sapiens_hsa053202.64745179
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.34879126
4B cell receptor signaling pathway_Homo sapiens_hsa046622.18053817
5Long-term potentiation_Homo sapiens_hsa047202.06503286
6Olfactory transduction_Homo sapiens_hsa047401.99641915
7T cell receptor signaling pathway_Homo sapiens_hsa046601.98156938
8Leishmaniasis_Homo sapiens_hsa051401.90062050
9Osteoclast differentiation_Homo sapiens_hsa043801.82050075
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.81035891
11Viral myocarditis_Homo sapiens_hsa054161.79614407
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69876656
13Nicotine addiction_Homo sapiens_hsa050331.68858705
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63574381
15Malaria_Homo sapiens_hsa051441.61913888
16Chemokine signaling pathway_Homo sapiens_hsa040621.61871066
17Morphine addiction_Homo sapiens_hsa050321.59022971
18Circadian entrainment_Homo sapiens_hsa047131.51310190
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.50141850
20Synaptic vesicle cycle_Homo sapiens_hsa047211.49486509
21Graft-versus-host disease_Homo sapiens_hsa053321.47172482
22Other glycan degradation_Homo sapiens_hsa005111.43119526
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42171247
24Tuberculosis_Homo sapiens_hsa051521.41012084
25Amphetamine addiction_Homo sapiens_hsa050311.40442023
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38818691
27Salivary secretion_Homo sapiens_hsa049701.38084658
28Hematopoietic cell lineage_Homo sapiens_hsa046401.35703626
29Glutamatergic synapse_Homo sapiens_hsa047241.34652342
30Measles_Homo sapiens_hsa051621.31234810
31Gastric acid secretion_Homo sapiens_hsa049711.28030580
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27210205
33Type I diabetes mellitus_Homo sapiens_hsa049401.26640712
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.25064368
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24675221
36VEGF signaling pathway_Homo sapiens_hsa043701.22596100
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22056284
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21826031
39Phagosome_Homo sapiens_hsa041451.18034631
40Dopaminergic synapse_Homo sapiens_hsa047281.17624882
41Allograft rejection_Homo sapiens_hsa053301.16814289
42Oxytocin signaling pathway_Homo sapiens_hsa049211.15109200
43Cholinergic synapse_Homo sapiens_hsa047251.14988593
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14771853
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13547195
46Antigen processing and presentation_Homo sapiens_hsa046121.12046389
47Shigellosis_Homo sapiens_hsa051311.11966944
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.10380413
49GABAergic synapse_Homo sapiens_hsa047271.09446696
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09434607
51Salmonella infection_Homo sapiens_hsa051321.08866279
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07434837
53African trypanosomiasis_Homo sapiens_hsa051431.07218292
54Pertussis_Homo sapiens_hsa051331.07145493
55Calcium signaling pathway_Homo sapiens_hsa040201.06034949
56Renin secretion_Homo sapiens_hsa049241.03882317
57Platelet activation_Homo sapiens_hsa046111.03289252
58Hepatitis C_Homo sapiens_hsa051601.02042631
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99880097
60Glioma_Homo sapiens_hsa052140.99868266
61Non-small cell lung cancer_Homo sapiens_hsa052230.99520277
62GnRH signaling pathway_Homo sapiens_hsa049120.97513143
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94227205
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.94202282
65Hepatitis B_Homo sapiens_hsa051610.92698265
66Apoptosis_Homo sapiens_hsa042100.92376688
67Rheumatoid arthritis_Homo sapiens_hsa053230.92143421
68Influenza A_Homo sapiens_hsa051640.91910882
69Staphylococcus aureus infection_Homo sapiens_hsa051500.91334272
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89893341
71Epstein-Barr virus infection_Homo sapiens_hsa051690.88937513
72Long-term depression_Homo sapiens_hsa047300.87380691
73Acute myeloid leukemia_Homo sapiens_hsa052210.85815750
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.84361515
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84251568
76Collecting duct acid secretion_Homo sapiens_hsa049660.83936124
77cAMP signaling pathway_Homo sapiens_hsa040240.83773478
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83717353
79TNF signaling pathway_Homo sapiens_hsa046680.83536872
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.83000198
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79886562
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79578334
83Asthma_Homo sapiens_hsa053100.77351476
84Viral carcinogenesis_Homo sapiens_hsa052030.75414036
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75326914
86Toxoplasmosis_Homo sapiens_hsa051450.74580375
87Insulin secretion_Homo sapiens_hsa049110.74320313
88Type II diabetes mellitus_Homo sapiens_hsa049300.72462698
89Estrogen signaling pathway_Homo sapiens_hsa049150.71877282
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.70200382
91Cocaine addiction_Homo sapiens_hsa050300.70167846
92Serotonergic synapse_Homo sapiens_hsa047260.69800891
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69078914
94Endocytosis_Homo sapiens_hsa041440.69030964
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68816548
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68475196
97Choline metabolism in cancer_Homo sapiens_hsa052310.68424123
98MAPK signaling pathway_Homo sapiens_hsa040100.67895237
99HTLV-I infection_Homo sapiens_hsa051660.67580595
100Renal cell carcinoma_Homo sapiens_hsa052110.66439220
101Herpes simplex infection_Homo sapiens_hsa051680.65826705
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62283710
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61825714
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61100987
105Dorso-ventral axis formation_Homo sapiens_hsa043200.61070296
106Pancreatic cancer_Homo sapiens_hsa052120.59745639
107ErbB signaling pathway_Homo sapiens_hsa040120.59703150
108Chronic myeloid leukemia_Homo sapiens_hsa052200.59250251
109Inositol phosphate metabolism_Homo sapiens_hsa005620.58480404
110Colorectal cancer_Homo sapiens_hsa052100.57947928
111Legionellosis_Homo sapiens_hsa051340.57799963
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.56833413
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.56511824
114Lysosome_Homo sapiens_hsa041420.55320831
115Notch signaling pathway_Homo sapiens_hsa043300.54762302
116Endometrial cancer_Homo sapiens_hsa052130.54744911
117* Rap1 signaling pathway_Homo sapiens_hsa040150.54716086
118FoxO signaling pathway_Homo sapiens_hsa040680.53766978
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52868207
120Prolactin signaling pathway_Homo sapiens_hsa049170.52685964
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49807344
122mTOR signaling pathway_Homo sapiens_hsa041500.48854385
123Regulation of autophagy_Homo sapiens_hsa041400.45416819
124HIF-1 signaling pathway_Homo sapiens_hsa040660.45290635
125Insulin resistance_Homo sapiens_hsa049310.45013724
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44990442
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42195923
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38944939
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35763487
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.35573902
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34186217
132Amoebiasis_Homo sapiens_hsa051460.32161355

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