RGS17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.63137692
2vocalization behavior (GO:0071625)5.40891378
3synaptic vesicle exocytosis (GO:0016079)5.40386232
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.36125727
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.05307268
6protein localization to synapse (GO:0035418)4.99704085
7pyrimidine nucleobase catabolic process (GO:0006208)4.94157910
8glutamate secretion (GO:0014047)4.83326862
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.81349220
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.75488834
11regulation of synaptic vesicle exocytosis (GO:2000300)4.73612880
12nucleobase catabolic process (GO:0046113)4.60393555
13regulation of glutamate receptor signaling pathway (GO:1900449)4.60389632
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.54244701
15neuronal action potential propagation (GO:0019227)4.51667662
16presynaptic membrane assembly (GO:0097105)4.48738111
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.44374776
18synaptic vesicle maturation (GO:0016188)4.27721094
19locomotory exploration behavior (GO:0035641)4.27710066
20neurotransmitter secretion (GO:0007269)4.22743113
21regulation of synaptic vesicle transport (GO:1902803)4.20317810
22glutamate receptor signaling pathway (GO:0007215)4.18129459
23presynaptic membrane organization (GO:0097090)4.16681458
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.10384842
25neuron-neuron synaptic transmission (GO:0007270)4.09891679
26synaptic transmission, glutamatergic (GO:0035249)4.05353571
27postsynaptic membrane organization (GO:0001941)4.00643890
28synaptic vesicle docking involved in exocytosis (GO:0016081)3.99483075
29neuron recognition (GO:0008038)3.87382970
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.84744675
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.84387330
32exploration behavior (GO:0035640)3.82571419
33neurotransmitter-gated ion channel clustering (GO:0072578)3.79498028
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.70165301
35neurotransmitter transport (GO:0006836)3.67353609
36gamma-aminobutyric acid transport (GO:0015812)3.66494021
37behavioral response to nicotine (GO:0035095)3.59620579
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59400336
39regulation of neuronal synaptic plasticity (GO:0048168)3.57466183
40response to histamine (GO:0034776)3.54297908
41regulation of postsynaptic membrane potential (GO:0060078)3.53448761
42startle response (GO:0001964)3.51099198
43positive regulation of synapse assembly (GO:0051965)3.50518604
44positive regulation of synaptic transmission, GABAergic (GO:0032230)3.49662492
45proline transport (GO:0015824)3.49227730
46behavioral response to ethanol (GO:0048149)3.48932455
47nonmotile primary cilium assembly (GO:0035058)3.47349361
48regulation of vesicle fusion (GO:0031338)3.44504846
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.43927424
50transmission of nerve impulse (GO:0019226)3.41746722
51axonal fasciculation (GO:0007413)3.38775062
52positive regulation of membrane potential (GO:0045838)3.38211061
53righting reflex (GO:0060013)3.38000544
54synaptic vesicle endocytosis (GO:0048488)3.37976992
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.36901658
56long-term synaptic potentiation (GO:0060291)3.36177189
57long-term memory (GO:0007616)3.36125427
58regulation of neurotransmitter levels (GO:0001505)3.35257248
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34762398
60dendritic spine morphogenesis (GO:0060997)3.33693315
61protein-cofactor linkage (GO:0018065)3.32364469
62layer formation in cerebral cortex (GO:0021819)3.31948067
63regulation of neurotransmitter secretion (GO:0046928)3.31742884
64negative regulation of cytosolic calcium ion concentration (GO:0051481)3.26099575
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.24691226
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.21459438
67auditory behavior (GO:0031223)3.18617128
68synapse assembly (GO:0007416)3.16471038
69detection of calcium ion (GO:0005513)3.14817510
70cerebellar Purkinje cell differentiation (GO:0021702)3.14764679
71membrane hyperpolarization (GO:0060081)3.14268472
72regulation of glutamate secretion (GO:0014048)3.13053047
73behavioral response to cocaine (GO:0048148)3.12299522
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.12008540
75regulation of neurotransmitter transport (GO:0051588)3.11574164
76regulation of synaptic plasticity (GO:0048167)3.09959374
77membrane depolarization (GO:0051899)3.08254749
78mechanosensory behavior (GO:0007638)3.07939777
79negative regulation of dendrite morphogenesis (GO:0050774)3.07919643
80protein localization to cilium (GO:0061512)3.07817527
81neuronal action potential (GO:0019228)3.07624852
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.05685140
83regulation of synaptic transmission, GABAergic (GO:0032228)3.05326409
84cerebellar granule cell differentiation (GO:0021707)3.03489979
85activation of protein kinase A activity (GO:0034199)3.03218259
86synaptic transmission (GO:0007268)3.03175785
87positive regulation of neurotransmitter transport (GO:0051590)3.01615131
88positive regulation of synapse maturation (GO:0090129)2.99468842
89cAMP catabolic process (GO:0006198)2.97057015
90synaptic vesicle transport (GO:0048489)2.96866952
91establishment of synaptic vesicle localization (GO:0097480)2.96866952
92neuromuscular process controlling posture (GO:0050884)2.94667924
93regulation of synapse assembly (GO:0051963)2.94430441
94response to auditory stimulus (GO:0010996)2.94137683
95regulation of synapse structural plasticity (GO:0051823)2.94022085
96regulation of protein kinase A signaling (GO:0010738)2.93177379
97neural tube formation (GO:0001841)2.93143758
98membrane depolarization during action potential (GO:0086010)2.93110826
99learning (GO:0007612)2.92686451
100regulation of cilium movement (GO:0003352)2.92440233
101behavioral fear response (GO:0001662)2.91494518
102behavioral defense response (GO:0002209)2.91494518
103glycosphingolipid biosynthetic process (GO:0006688)2.91464692
104positive regulation of neurotransmitter secretion (GO:0001956)2.91325943
105positive regulation of synaptic transmission (GO:0050806)2.91069941
106calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.90295482
107epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89548392
108atrial cardiac muscle cell action potential (GO:0086014)2.87839796
109retinal cone cell development (GO:0046549)2.87276102
110fear response (GO:0042596)2.86541680
111intraspecies interaction between organisms (GO:0051703)2.85360183
112social behavior (GO:0035176)2.85360183
113regulation of synaptic transmission (GO:0050804)2.85139750
114response to pheromone (GO:0019236)2.84618495
115regulation of dendritic spine morphogenesis (GO:0061001)2.84539749
116calcium ion-dependent exocytosis (GO:0017156)2.83463836
117synapse organization (GO:0050808)2.83162548
118ATP hydrolysis coupled proton transport (GO:0015991)2.81538065
119glycerophospholipid catabolic process (GO:0046475)2.76673078
120retinal ganglion cell axon guidance (GO:0031290)2.75528451
121cyclic nucleotide catabolic process (GO:0009214)2.72269783
122axoneme assembly (GO:0035082)2.66933065
123L-fucose catabolic process (GO:0042355)2.66415282
124fucose catabolic process (GO:0019317)2.66415282
125L-fucose metabolic process (GO:0042354)2.66415282
126regulation of action potential (GO:0098900)2.65302833
127serotonin metabolic process (GO:0042428)2.64948049
128regulation of neurotransmitter uptake (GO:0051580)2.63723631
129protein polyglutamylation (GO:0018095)2.63283137
130detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63163322
131DNA double-strand break processing (GO:0000729)2.61450387
132central nervous system projection neuron axonogenesis (GO:0021952)2.61082777
133cornea development in camera-type eye (GO:0061303)2.60244889
134cilium organization (GO:0044782)2.59736197
135intraciliary transport (GO:0042073)2.59676105
136cilium morphogenesis (GO:0060271)2.57900138
137cilium assembly (GO:0042384)2.57090364
138positive regulation of mitochondrial fission (GO:0090141)2.56948124
139platelet dense granule organization (GO:0060155)2.53955691
140dendrite morphogenesis (GO:0048813)2.53390561
141reflex (GO:0060004)2.53048822
142limb bud formation (GO:0060174)2.51677053
143regulation of respiratory system process (GO:0044065)2.50222065
144water-soluble vitamin biosynthetic process (GO:0042364)2.49629371
145indolalkylamine metabolic process (GO:0006586)2.49122571
146central nervous system neuron axonogenesis (GO:0021955)2.48061944
147action potential (GO:0001508)2.48020934
148kidney morphogenesis (GO:0060993)2.47689060
149photoreceptor cell maintenance (GO:0045494)2.47579012
150epithelial cilium movement (GO:0003351)2.47005646
151regulation of feeding behavior (GO:0060259)2.45735620
152regulation of hexokinase activity (GO:1903299)2.40908694
153regulation of glucokinase activity (GO:0033131)2.40908694
154inner ear receptor cell development (GO:0060119)2.40442983
155spinal cord motor neuron differentiation (GO:0021522)2.34971560
156regulation of telomere maintenance (GO:0032204)2.34356589
157adult behavior (GO:0030534)2.34281173
158protein complex biogenesis (GO:0070271)2.34127014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.76183399
2GBX2_23144817_ChIP-Seq_PC3_Human4.20311109
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95722433
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89540489
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84141028
6TAF15_26573619_Chip-Seq_HEK293_Human2.65686925
7REST_21632747_ChIP-Seq_MESCs_Mouse2.47247065
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.46990630
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46150350
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39393361
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39393361
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38459585
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34263101
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31341677
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.30845849
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28882077
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24000296
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23503369
19* EED_16625203_ChIP-ChIP_MESCs_Mouse2.21617050
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19612070
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16180467
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16054220
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10053054
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04231799
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04181826
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98168661
27* EZH2_27294783_Chip-Seq_ESCs_Mouse1.97940841
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.94075122
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92927168
30* REST_18959480_ChIP-ChIP_MESCs_Mouse1.90970551
31DROSHA_22980978_ChIP-Seq_HELA_Human1.89009839
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88188738
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.86863185
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86785006
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83509801
36AR_21572438_ChIP-Seq_LNCaP_Human1.81543305
37* P300_19829295_ChIP-Seq_ESCs_Human1.78777023
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.78766754
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75603683
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75310764
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74557738
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67290684
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.67035871
44VDR_22108803_ChIP-Seq_LS180_Human1.64933255
45IGF1R_20145208_ChIP-Seq_DFB_Human1.64661023
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61471707
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.55085247
48RNF2_27304074_Chip-Seq_NSC_Mouse1.54322961
49* FUS_26573619_Chip-Seq_HEK293_Human1.50275626
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.49431186
51* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47817231
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46364724
53CBP_20019798_ChIP-Seq_JUKART_Human1.46364724
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45896670
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44364962
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40908042
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38042193
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37355444
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37176764
60AR_25329375_ChIP-Seq_VCAP_Human1.37171736
61STAT3_23295773_ChIP-Seq_U87_Human1.36651157
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35700851
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34969507
64* SOX2_21211035_ChIP-Seq_LN229_Gbm1.32774079
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32586971
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30310384
67ZNF274_21170338_ChIP-Seq_K562_Hela1.29195154
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28359973
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27433654
70ER_23166858_ChIP-Seq_MCF-7_Human1.26405354
71* SMAD_19615063_ChIP-ChIP_OVARY_Human1.26330599
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22202274
73TCF4_23295773_ChIP-Seq_U87_Human1.22096124
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21483100
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21123139
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.20848279
77TCF4_22108803_ChIP-Seq_LS180_Human1.20424595
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20069612
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19942138
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19914334
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18777629
82RUNX2_22187159_ChIP-Seq_PCA_Human1.18696157
83* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18635917
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16891009
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15002117
86* FLI1_21867929_ChIP-Seq_TH2_Mouse1.14849535
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14211286
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13319082
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12969539
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11869278
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11573159
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.11283105
93JUN_21703547_ChIP-Seq_K562_Human1.11172750
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10825302
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.10232924
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09802488
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09802488
98TP53_22573176_ChIP-Seq_HFKS_Human1.09784260
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09693278
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.09662321
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.09590908
102* EZH2_27294783_Chip-Seq_NPCs_Mouse1.09576692
103IRF1_19129219_ChIP-ChIP_H3396_Human1.08944772
104AR_19668381_ChIP-Seq_PC3_Human1.08091445
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05783124
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.04913030
107* RING1B_27294783_Chip-Seq_ESCs_Mouse1.04870358
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04783194
109PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04620663
110SOX2_19829295_ChIP-Seq_ESCs_Human1.04445289
111NANOG_19829295_ChIP-Seq_ESCs_Human1.04445289
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03745872
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.02901803
114KDM2B_26808549_Chip-Seq_REH_Human1.02587137
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.02430566
116AHR_22903824_ChIP-Seq_MCF-7_Human1.01553796
117BCAT_22108803_ChIP-Seq_LS180_Human1.01500379
118TP53_18474530_ChIP-ChIP_U2OS_Human1.01409168
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01126639
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.00496612
121ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00184505
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99609289
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99143777
124P53_22387025_ChIP-Seq_ESCs_Mouse0.98463501
125CMYC_18555785_Chip-Seq_ESCs_Mouse0.97243409
126RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96387199
127CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93991914
128EWS_26573619_Chip-Seq_HEK293_Human0.93004801
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92153570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.15389331
2MP0004859_abnormal_synaptic_plasticity4.81784145
3MP0003635_abnormal_synaptic_transmissio3.74712666
4MP0004270_analgesia3.36730256
5MP0001968_abnormal_touch/_nociception3.32209342
6MP0009745_abnormal_behavioral_response3.30378738
7MP0009046_muscle_twitch3.25457547
8MP0002064_seizures3.08647887
9MP0002063_abnormal_learning/memory/cond3.00626600
10MP0002572_abnormal_emotion/affect_behav2.82899146
11MP0002734_abnormal_mechanical_nocicepti2.75329978
12MP0002736_abnormal_nociception_after2.68970795
13MP0002272_abnormal_nervous_system2.67581395
14MP0006276_abnormal_autonomic_nervous2.62701000
15MP0005423_abnormal_somatic_nervous2.62009327
16MP0001486_abnormal_startle_reflex2.47595864
17MP0002735_abnormal_chemical_nociception2.47030803
18MP0001501_abnormal_sleep_pattern2.35136243
19MP0001440_abnormal_grooming_behavior2.27722906
20MP0001529_abnormal_vocalization2.18555861
21MP0002733_abnormal_thermal_nociception2.17213218
22MP0002067_abnormal_sensory_capabilities2.13178769
23MP0001970_abnormal_pain_threshold2.09827411
24MP0005646_abnormal_pituitary_gland2.06131185
25MP0005645_abnormal_hypothalamus_physiol2.03804904
26MP0002822_catalepsy1.98030504
27MP0003122_maternal_imprinting1.92593748
28MP0005386_behavior/neurological_phenoty1.87266359
29MP0004924_abnormal_behavior1.87266359
30MP0003787_abnormal_imprinting1.82215413
31MP0002184_abnormal_innervation1.81476852
32MP0002557_abnormal_social/conspecific_i1.81182074
33MP0001905_abnormal_dopamine_level1.79335052
34MP0001188_hyperpigmentation1.78920173
35MP0000778_abnormal_nervous_system1.76558349
36MP0003195_calcinosis1.69892778
37MP0009780_abnormal_chondrocyte_physiolo1.65546501
38MP0004142_abnormal_muscle_tone1.64337748
39MP0001984_abnormal_olfaction1.62737564
40MP0003879_abnormal_hair_cell1.62316115
41MP0010386_abnormal_urinary_bladder1.60856270
42MP0004133_heterotaxia1.53867189
43MP0008569_lethality_at_weaning1.46421619
44MP0001502_abnormal_circadian_rhythm1.42919441
45MP0002837_dystrophic_cardiac_calcinosis1.41150761
46MP0003890_abnormal_embryonic-extraembry1.40606909
47MP0002909_abnormal_adrenal_gland1.37137156
48MP0002876_abnormal_thyroid_physiology1.37124997
49MP0002066_abnormal_motor_capabilities/c1.35920393
50MP0000955_abnormal_spinal_cord1.34790704
51MP0004811_abnormal_neuron_physiology1.33454005
52MP0002882_abnormal_neuron_morphology1.31780678
53MP0003329_amyloid_beta_deposits1.27848444
54MP0004742_abnormal_vestibular_system1.20786841
55MP0000427_abnormal_hair_cycle1.17882319
56MP0000013_abnormal_adipose_tissue1.16871221
57MP0002653_abnormal_ependyma_morphology1.15792811
58MP0004858_abnormal_nervous_system1.10407493
59MP0003136_yellow_coat_color1.10332358
60MP0003633_abnormal_nervous_system1.07737012
61MP0005187_abnormal_penis_morphology1.05675946
62MP0005551_abnormal_eye_electrophysiolog1.03283814
63MP0005174_abnormal_tail_pigmentation1.02653190
64MP0005084_abnormal_gallbladder_morpholo1.02184423
65MP0004145_abnormal_muscle_electrophysio1.01540948
66MP0002938_white_spotting1.01239344
67MP0000631_abnormal_neuroendocrine_gland1.00295668
68MP0002638_abnormal_pupillary_reflex0.99946169
69MP0001963_abnormal_hearing_physiology0.98925349
70MP0008872_abnormal_physiological_respon0.98636770
71MP0002152_abnormal_brain_morphology0.98590309
72MP0000751_myopathy0.97766084
73MP0004147_increased_porphyrin_level0.96739417
74MP0002229_neurodegeneration0.94782960
75MP0004885_abnormal_endolymph0.93609182
76MP0003631_nervous_system_phenotype0.93485808
77MP0002928_abnormal_bile_duct0.91641633
78MP0002069_abnormal_eating/drinking_beha0.89998254
79MP0005195_abnormal_posterior_eye0.88871962
80MP0006072_abnormal_retinal_apoptosis0.88434472
81MP0000516_abnormal_urinary_system0.87784677
82MP0005367_renal/urinary_system_phenotyp0.87784677
83MP0005379_endocrine/exocrine_gland_phen0.87442306
84MP0002234_abnormal_pharynx_morphology0.87077149
85MP0003119_abnormal_digestive_system0.87034464
86MP0003121_genomic_imprinting0.86784413
87MP0005535_abnormal_body_temperature0.85041933
88MP0002752_abnormal_somatic_nervous0.84164071
89MP0003011_delayed_dark_adaptation0.84156937
90MP0001664_abnormal_digestion0.83745960
91MP0005499_abnormal_olfactory_system0.82970560
92MP0005394_taste/olfaction_phenotype0.82970560
93MP0000569_abnormal_digit_pigmentation0.81044480
94MP0004085_abnormal_heartbeat0.79541258
95MP0003937_abnormal_limbs/digits/tail_de0.78465444
96MP0001986_abnormal_taste_sensitivity0.77878143
97MP0002160_abnormal_reproductive_system0.76877548
98MP0000647_abnormal_sebaceous_gland0.76618943
99MP0008874_decreased_physiological_sensi0.76390569
100MP0002102_abnormal_ear_morphology0.75362193
101MP0001485_abnormal_pinna_reflex0.74702260
102MP0008877_abnormal_DNA_methylation0.71535500
103MP0003634_abnormal_glial_cell0.70384627
104MP0000026_abnormal_inner_ear0.70158778
105MP0005409_darkened_coat_color0.68522268
106MP0003183_abnormal_peptide_metabolism0.68163511
107MP0004484_altered_response_of0.67058414
108MP0002163_abnormal_gland_morphology0.66321982
109MP0001177_atelectasis0.64690437
110MP0004215_abnormal_myocardial_fiber0.64175454
111MP0006292_abnormal_olfactory_placode0.63136044
112MP0003632_abnormal_nervous_system0.61389188
113MP0002751_abnormal_autonomic_nervous0.59947283
114MP0004043_abnormal_pH_regulation0.59192605
115MP0001943_abnormal_respiration0.58798634
116MP0000920_abnormal_myelination0.58074958
117MP0005171_absent_coat_pigmentation0.56362118
118MP0003137_abnormal_impulse_conducting0.55591447
119MP0001299_abnormal_eye_distance/0.54859823
120MP0005253_abnormal_eye_physiology0.53394287
121MP0000538_abnormal_urinary_bladder0.51589202

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.91808934
2Focal seizures (HP:0007359)5.40237929
3Myokymia (HP:0002411)5.24377538
4Atonic seizures (HP:0010819)5.16804087
5Epileptic encephalopathy (HP:0200134)5.12524140
6Febrile seizures (HP:0002373)4.63548397
7Visual hallucinations (HP:0002367)4.54250751
8Absence seizures (HP:0002121)4.30773644
9Hyperventilation (HP:0002883)4.15550923
10Progressive cerebellar ataxia (HP:0002073)4.09538141
11Generalized tonic-clonic seizures (HP:0002069)4.00995160
12Dialeptic seizures (HP:0011146)3.90133202
13Broad-based gait (HP:0002136)3.63226150
14Limb dystonia (HP:0002451)3.36256943
15Pancreatic cysts (HP:0001737)3.33287959
16Pancreatic fibrosis (HP:0100732)3.22990203
17Type II lissencephaly (HP:0007260)3.20098773
18Abnormality of midbrain morphology (HP:0002418)3.15561934
19Molar tooth sign on MRI (HP:0002419)3.15561934
20Nephronophthisis (HP:0000090)3.14882674
21Gaze-evoked nystagmus (HP:0000640)3.07750572
22True hermaphroditism (HP:0010459)3.02996412
23Gait imbalance (HP:0002141)2.99029501
24Excessive salivation (HP:0003781)2.92306823
25Drooling (HP:0002307)2.92306823
26Lissencephaly (HP:0001339)2.87688887
27Abnormal eating behavior (HP:0100738)2.85666723
28Amblyopia (HP:0000646)2.83368510
29Polyphagia (HP:0002591)2.80830899
30Abnormal hair whorl (HP:0010721)2.80735225
31Progressive inability to walk (HP:0002505)2.80545990
32Impaired vibration sensation in the lower limbs (HP:0002166)2.78508822
33Pendular nystagmus (HP:0012043)2.74349015
34Dysdiadochokinesis (HP:0002075)2.72042445
35Truncal ataxia (HP:0002078)2.71854766
36Poor eye contact (HP:0000817)2.68204800
37Epileptiform EEG discharges (HP:0011182)2.67283863
38Supranuclear gaze palsy (HP:0000605)2.66376246
39Abnormality of the renal medulla (HP:0100957)2.65863371
40Pheochromocytoma (HP:0002666)2.64626743
41Congenital primary aphakia (HP:0007707)2.64479791
42Medial flaring of the eyebrow (HP:0010747)2.64177900
43Dysmetria (HP:0001310)2.60441678
44Absent speech (HP:0001344)2.58002353
45Anxiety (HP:0000739)2.56917433
46Neuroendocrine neoplasm (HP:0100634)2.54175477
47Urinary bladder sphincter dysfunction (HP:0002839)2.52309025
48EEG with generalized epileptiform discharges (HP:0011198)2.51182503
49Optic nerve hypoplasia (HP:0000609)2.49523148
50Inability to walk (HP:0002540)2.47303921
51Protruding tongue (HP:0010808)2.47275026
52Action tremor (HP:0002345)2.46703204
53Fetal akinesia sequence (HP:0001989)2.45051890
54Congenital stationary night blindness (HP:0007642)2.44378437
55Volvulus (HP:0002580)2.44190067
56Ankle clonus (HP:0011448)2.43402493
57Nephrogenic diabetes insipidus (HP:0009806)2.42246610
58Depression (HP:0000716)2.37884618
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.34700258
60Absent/shortened dynein arms (HP:0200106)2.34700258
61Chronic hepatic failure (HP:0100626)2.34416762
62Genital tract atresia (HP:0001827)2.31743817
63Failure to thrive in infancy (HP:0001531)2.31344762
64Hypsarrhythmia (HP:0002521)2.30662839
65Cerebellar dysplasia (HP:0007033)2.29790899
66Abnormal social behavior (HP:0012433)2.29160713
67Impaired social interactions (HP:0000735)2.29160713
68Specific learning disability (HP:0001328)2.29012376
69Blue irides (HP:0000635)2.28649014
70Hemiparesis (HP:0001269)2.28510862
71Vaginal atresia (HP:0000148)2.27018232
72Papilledema (HP:0001085)2.26694428
73Abnormality of the corticospinal tract (HP:0002492)2.26236910
74Agitation (HP:0000713)2.25558932
75Intestinal atresia (HP:0011100)2.24395731
76Scanning speech (HP:0002168)2.24130052
77Pachygyria (HP:0001302)2.23515414
78Generalized myoclonic seizures (HP:0002123)2.19880748
79Insidious onset (HP:0003587)2.19080395
80Termporal pattern (HP:0011008)2.19080395
81Spastic gait (HP:0002064)2.19075899
82Abnormal ciliary motility (HP:0012262)2.17778423
83Large for gestational age (HP:0001520)2.17767985
84Diplopia (HP:0000651)2.17695349
85Abnormality of binocular vision (HP:0011514)2.17695349
86Mutism (HP:0002300)2.17381705
87Acute necrotizing encephalopathy (HP:0006965)2.15905204
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15175190
89Hyperthyroidism (HP:0000836)2.14893293
90Esotropia (HP:0000565)2.14067035
91Abnormality of the renal cortex (HP:0011035)2.13178329
92Neurofibrillary tangles (HP:0002185)2.12136269
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.10904514
94Degeneration of the lateral corticospinal tracts (HP:0002314)2.10904514
95Postural instability (HP:0002172)2.10811480
96Sclerocornea (HP:0000647)2.09835051
97Genetic anticipation (HP:0003743)2.08252967
98Progressive macrocephaly (HP:0004481)2.07253702
99Cerebral inclusion bodies (HP:0100314)2.06852710
100Hypoventilation (HP:0002791)2.03950567
101Abnormality of salivation (HP:0100755)2.03853424
102Poor suck (HP:0002033)2.01965668
103Postaxial hand polydactyly (HP:0001162)2.00946740
104Hypothermia (HP:0002045)1.99880111
105Aplasia/Hypoplasia of the tongue (HP:0010295)1.97301412
106Cystic liver disease (HP:0006706)1.96597691
107Impaired smooth pursuit (HP:0007772)1.96344702
108Abnormality of the labia minora (HP:0012880)1.95916181
109Abnormal respiratory motile cilium physiology (HP:0012261)1.95674870
110Bradykinesia (HP:0002067)1.94866586
111Spastic tetraplegia (HP:0002510)1.94849902
112Abolished electroretinogram (ERG) (HP:0000550)1.94112734
113Narrow nasal bridge (HP:0000446)1.93758290
114Status epilepticus (HP:0002133)1.93375804
115Psychosis (HP:0000709)1.93174691
116Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.92532506
117Abnormal mitochondria in muscle tissue (HP:0008316)1.91102280
118Narrow forehead (HP:0000341)1.90981692
119Methylmalonic acidemia (HP:0002912)1.89459104
120Poor coordination (HP:0002370)1.89141273
121Stereotypic behavior (HP:0000733)1.88608660
122Exotropia (HP:0000577)1.87654079
123Retinal dysplasia (HP:0007973)1.87364175
124Lower limb muscle weakness (HP:0007340)1.86991920
125Torticollis (HP:0000473)1.86897170
126Akinesia (HP:0002304)1.86787035
127Urinary urgency (HP:0000012)1.85752571
128Focal dystonia (HP:0004373)1.83047388
129Aplasia/Hypoplasia of the tibia (HP:0005772)1.81372846
130Widely spaced teeth (HP:0000687)1.80780600
131Broad foot (HP:0001769)1.80363128
132Abnormality of macular pigmentation (HP:0008002)1.78492687
133Renal cortical cysts (HP:0000803)1.76618764
134Short foot (HP:0001773)1.74835302
135Polydipsia (HP:0001959)1.70505074
136Abnormal drinking behavior (HP:0030082)1.70505074
137Furrowed tongue (HP:0000221)1.69777358
138Chorioretinal atrophy (HP:0000533)1.69612452
139Fair hair (HP:0002286)1.69499927
140Decreased testicular size (HP:0008734)1.69483537
141Muscular hypotonia of the trunk (HP:0008936)1.68043935
142Gastrointestinal atresia (HP:0002589)1.66726847
143Septo-optic dysplasia (HP:0100842)1.65877398
144Severe muscular hypotonia (HP:0006829)1.65034533
145Anencephaly (HP:0002323)1.64972550
146Aplasia/Hypoplasia of the lens (HP:0008063)1.63696110
147Congenital hepatic fibrosis (HP:0002612)1.63394881
148Thyroid-stimulating hormone excess (HP:0002925)1.63268640
149Tubular atrophy (HP:0000092)1.62865586
150Male pseudohermaphroditism (HP:0000037)1.61962015
151Scrotal hypoplasia (HP:0000046)1.61937182
152Amyotrophic lateral sclerosis (HP:0007354)1.61328785
153Morphological abnormality of the pyramidal tract (HP:0002062)1.61112699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.41277681
2FRK4.24388749
3NTRK34.03690562
4MAP3K93.22788919
5EPHA43.21543861
6MAP3K43.19789656
7MAP3K123.18523425
8MAP4K23.12394231
9MAP2K73.01672206
10MARK12.56979717
11MINK12.14353426
12NTRK22.02858405
13DAPK22.02723396
14MAP2K42.00422941
15TNIK1.92587388
16ARAF1.89138631
17PNCK1.84319214
18ACVR1B1.80691424
19PLK21.78807637
20TRIM281.77163793
21MAPK131.76962010
22CDK191.76871787
23STK38L1.75054868
24GRK11.66171487
25PAK61.63017365
26GRK51.61291038
27DYRK21.56887543
28ERBB31.55219083
29RIPK41.54275414
30PRPF4B1.49961055
31EPHA31.45720095
32KSR21.44185984
33NTRK11.43948868
34MKNK21.43507377
35PINK11.39621581
36OXSR11.37930852
37DAPK11.37209154
38ZAK1.33751308
39BMPR21.29881161
40CDK51.26869758
41KSR11.25238609
42CAMK2A1.21474975
43AKT31.18385372
44TLK11.15544251
45PRKCG1.15152262
46MAP3K131.14124509
47LATS21.10453063
48UHMK11.09966196
49CSNK1G11.08906405
50WNK31.06694958
51SIK21.06105806
52CAMKK21.03343772
53CAMK2B1.01355059
54FES1.00551592
55NUAK10.97390789
56BRAF0.96042049
57SGK2230.95489927
58SGK4940.95489927
59FGFR20.94073193
60CSNK1A1L0.92522670
61CSNK1G20.91679664
62NME10.90683136
63SGK20.87750037
64GRK70.87383824
65CAMKK10.86845747
66MUSK0.85261992
67CCNB10.84129602
68CDK180.81582394
69ADRBK20.81450466
70BCR0.81348755
71CDK140.78858027
72MAP3K20.77255952
73PRKD30.77070475
74MAP3K60.76904858
75STK380.76553731
76CDK150.76469604
77PRKCE0.76460500
78TNK20.74770716
79PAK30.72797427
80SIK30.72243420
81CAMK2D0.68996291
82PHKG20.68475057
83PHKG10.68475057
84CDK11A0.65064316
85DYRK1A0.64741181
86SGK10.64547617
87RAF10.64144939
88RPS6KA40.62307595
89FER0.61138566
90MKNK10.60855550
91STK110.59434297
92CAMK2G0.58860378
93MAP2K60.57721611
94BMPR1B0.57449271
95CAMK10.55220731
96TYRO30.55042884
97MOS0.54939312
98ADRBK10.54717780
99CSNK1G30.54465735
100PRKCZ0.54253122
101STK390.54192193
102TSSK60.53318320
103RET0.52680084
104PLK30.52065919
105BRSK20.51654825
106FGR0.50900333
107MAP3K10.50713959
108PTK2B0.48211778
109ERBB40.46435236
110WNK40.46415363
111NEK60.46085160
112MAPKAPK50.45584731
113CDK30.45271503
114PRKCH0.45162508
115ROCK20.44989398
116WNK10.44618625
117INSRR0.44155738
118SGK30.44147980
119CDC42BPA0.43573623
120VRK10.40117019
121PRKACA0.39847833
122PKN10.39740298
123EIF2AK30.39586684
124MAP2K10.39119701
125MST40.38409980
126PRKG10.37201345
127CSNK1D0.37100813
128MARK20.35885863
129CSNK1A10.35801623
130PRKACB0.35268538
131TRPM70.29866071
132DYRK30.29748465
133RPS6KA50.29621718
134CSNK1E0.28549512
135TAOK30.28483971
136PRKCI0.27610767
137WEE10.26912034
138PRKAA10.26905580
139IRAK10.26587678
140LIMK10.25153036
141TGFBR10.24181928

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.37965162
2Synaptic vesicle cycle_Homo sapiens_hsa047213.61994933
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.88525844
4GABAergic synapse_Homo sapiens_hsa047272.79938684
5Amphetamine addiction_Homo sapiens_hsa050312.56564070
6Morphine addiction_Homo sapiens_hsa050322.56469178
7Protein export_Homo sapiens_hsa030602.53400111
8Glutamatergic synapse_Homo sapiens_hsa047242.50496833
9Butanoate metabolism_Homo sapiens_hsa006502.49792501
10Collecting duct acid secretion_Homo sapiens_hsa049662.47257988
11Long-term potentiation_Homo sapiens_hsa047202.46958005
12Circadian entrainment_Homo sapiens_hsa047132.46673916
13Olfactory transduction_Homo sapiens_hsa047402.44862687
14Taste transduction_Homo sapiens_hsa047422.25341796
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.17239276
16Dopaminergic synapse_Homo sapiens_hsa047282.15705835
17Serotonergic synapse_Homo sapiens_hsa047262.13685278
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08613873
19Insulin secretion_Homo sapiens_hsa049112.07301128
20Salivary secretion_Homo sapiens_hsa049701.96338907
21Cocaine addiction_Homo sapiens_hsa050301.95386332
22Long-term depression_Homo sapiens_hsa047301.76624961
23Cholinergic synapse_Homo sapiens_hsa047251.75740115
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75181393
25Oxidative phosphorylation_Homo sapiens_hsa001901.74816338
26Renin secretion_Homo sapiens_hsa049241.68780930
27Gastric acid secretion_Homo sapiens_hsa049711.66802023
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62195929
29Vibrio cholerae infection_Homo sapiens_hsa051101.59053115
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57143811
31Calcium signaling pathway_Homo sapiens_hsa040201.53756307
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51903977
33Oxytocin signaling pathway_Homo sapiens_hsa049211.44427220
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43877527
35Selenocompound metabolism_Homo sapiens_hsa004501.43755715
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36893787
37GnRH signaling pathway_Homo sapiens_hsa049121.33219453
38Cardiac muscle contraction_Homo sapiens_hsa042601.32616654
39Basal transcription factors_Homo sapiens_hsa030221.32573559
40Alzheimers disease_Homo sapiens_hsa050101.28925594
41Parkinsons disease_Homo sapiens_hsa050121.24724505
42Gap junction_Homo sapiens_hsa045401.24559735
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23893788
44Linoleic acid metabolism_Homo sapiens_hsa005911.19422807
45cAMP signaling pathway_Homo sapiens_hsa040241.12936180
46Steroid biosynthesis_Homo sapiens_hsa001001.12832426
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10813653
48Axon guidance_Homo sapiens_hsa043601.08680525
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07068311
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06423880
51Phototransduction_Homo sapiens_hsa047441.04393282
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03103906
53Nitrogen metabolism_Homo sapiens_hsa009101.02177660
54Estrogen signaling pathway_Homo sapiens_hsa049151.01515139
55Tryptophan metabolism_Homo sapiens_hsa003800.95400858
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.94314455
57Melanogenesis_Homo sapiens_hsa049160.93297146
58Fanconi anemia pathway_Homo sapiens_hsa034600.93024246
59ErbB signaling pathway_Homo sapiens_hsa040120.92144058
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90331667
61Huntingtons disease_Homo sapiens_hsa050160.90091986
62Type II diabetes mellitus_Homo sapiens_hsa049300.87084237
63RNA degradation_Homo sapiens_hsa030180.87065755
64Dorso-ventral axis formation_Homo sapiens_hsa043200.84967351
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83592037
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83483715
67RNA polymerase_Homo sapiens_hsa030200.83449108
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82338615
69beta-Alanine metabolism_Homo sapiens_hsa004100.82263516
70Propanoate metabolism_Homo sapiens_hsa006400.81852813
71Oocyte meiosis_Homo sapiens_hsa041140.75921384
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75143480
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74592154
74Type I diabetes mellitus_Homo sapiens_hsa049400.74074830
75Pancreatic secretion_Homo sapiens_hsa049720.74006769
76Rheumatoid arthritis_Homo sapiens_hsa053230.72172219
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71914203
78Sulfur metabolism_Homo sapiens_hsa009200.71488930
79Glioma_Homo sapiens_hsa052140.71245090
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70843282
81ABC transporters_Homo sapiens_hsa020100.70460096
82MAPK signaling pathway_Homo sapiens_hsa040100.68160457
83Caffeine metabolism_Homo sapiens_hsa002320.66776673
84Thyroid hormone synthesis_Homo sapiens_hsa049180.66771935
85Circadian rhythm_Homo sapiens_hsa047100.66052966
86Peroxisome_Homo sapiens_hsa041460.64677446
87Homologous recombination_Homo sapiens_hsa034400.64567453
88Dilated cardiomyopathy_Homo sapiens_hsa054140.63749228
89Ovarian steroidogenesis_Homo sapiens_hsa049130.59991396
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59920244
91Ras signaling pathway_Homo sapiens_hsa040140.59842333
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58007689
93Alcoholism_Homo sapiens_hsa050340.56926984
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.55935074
95Choline metabolism in cancer_Homo sapiens_hsa052310.55673077
96Purine metabolism_Homo sapiens_hsa002300.54505131
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52883174
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49905669
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.49855482
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46287969
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45263781
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45182866
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44272730
104Phagosome_Homo sapiens_hsa041450.43912416
105Glucagon signaling pathway_Homo sapiens_hsa049220.43374388
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42832699
107Ether lipid metabolism_Homo sapiens_hsa005650.42584934
108Wnt signaling pathway_Homo sapiens_hsa043100.42369129
109Chemical carcinogenesis_Homo sapiens_hsa052040.41099402
110Glycerolipid metabolism_Homo sapiens_hsa005610.40862667
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40366469
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39909633
113Sphingolipid metabolism_Homo sapiens_hsa006000.39194600
114Metabolic pathways_Homo sapiens_hsa011000.38631625
115Inositol phosphate metabolism_Homo sapiens_hsa005620.38599135
116Hippo signaling pathway_Homo sapiens_hsa043900.38507728
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36387359
118Folate biosynthesis_Homo sapiens_hsa007900.35980932
119African trypanosomiasis_Homo sapiens_hsa051430.35444622
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.34967942
121Retinol metabolism_Homo sapiens_hsa008300.34412944
122Prion diseases_Homo sapiens_hsa050200.34144826
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33909763
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33783745
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33775428
126Rap1 signaling pathway_Homo sapiens_hsa040150.32678158
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32618800
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31004772
129Renal cell carcinoma_Homo sapiens_hsa052110.30757393
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.30354133
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30202842
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27993499
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.27226602
134Hedgehog signaling pathway_Homo sapiens_hsa043400.26379141
135Melanoma_Homo sapiens_hsa052180.25019345
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.24876195
137Regulation of autophagy_Homo sapiens_hsa041400.23542569
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22552200
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22271529
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19781563
141Insulin signaling pathway_Homo sapiens_hsa049100.19342325

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