RGS17P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of B cell differentiation (GO:0045579)5.81499863
2regulation of B cell receptor signaling pathway (GO:0050855)5.43898133
3mature B cell differentiation (GO:0002335)4.68698184
4negative regulation of B cell proliferation (GO:0030889)4.67658531
5immunoglobulin mediated immune response (GO:0016064)4.43915614
6positive regulation of gamma-delta T cell activation (GO:0046645)4.34999299
7regulation of B cell differentiation (GO:0045577)4.34238315
8hepatocyte apoptotic process (GO:0097284)4.27751540
9positive regulation of granulocyte differentiation (GO:0030854)4.23412909
10B cell receptor signaling pathway (GO:0050853)4.21656028
11neutrophil activation involved in immune response (GO:0002283)4.14288932
12negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.11006313
13response to peptidoglycan (GO:0032494)4.06904645
14regulation of alpha-beta T cell proliferation (GO:0046640)4.00081335
15mature B cell differentiation involved in immune response (GO:0002313)3.90053081
16regulation of B cell proliferation (GO:0030888)3.72325771
17detection of other organism (GO:0098543)3.69929815
18positive regulation of protein homooligomerization (GO:0032464)3.67390929
19neutrophil mediated immunity (GO:0002446)3.66363177
20negative regulation of interleukin-17 production (GO:0032700)3.66309749
21B cell mediated immunity (GO:0019724)3.60287667
22regulation of gamma-delta T cell differentiation (GO:0045586)3.58194662
23positive regulation of developmental pigmentation (GO:0048087)3.57857039
24cell wall macromolecule catabolic process (GO:0016998)3.54308328
25regulation of gamma-delta T cell activation (GO:0046643)3.52905191
26positive thymic T cell selection (GO:0045059)3.52669636
27cellular extravasation (GO:0045123)3.52568459
28phosphatidylglycerol biosynthetic process (GO:0006655)3.50798405
29detection of molecule of bacterial origin (GO:0032490)3.50679315
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.47336680
31autophagic vacuole fusion (GO:0000046)3.45412311
32negative regulation of alpha-beta T cell activation (GO:0046636)3.38987389
33hematopoietic stem cell proliferation (GO:0071425)3.35216908
34response to muramyl dipeptide (GO:0032495)3.30529733
35positive regulation of mast cell degranulation (GO:0043306)3.29589826
36positive regulation of mast cell activation involved in immune response (GO:0033008)3.29589826
37regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.25485260
38B cell activation (GO:0042113)3.25349479
39detection of external biotic stimulus (GO:0098581)3.23373864
40detection of bacterium (GO:0016045)3.22582176
41regulation of mast cell activation (GO:0033003)3.19547140
42negative thymic T cell selection (GO:0045060)3.16640621
43positive regulation of mast cell activation (GO:0033005)3.16606633
44positive T cell selection (GO:0043368)3.13782290
45regulation of B cell activation (GO:0050864)3.12623021
46negative regulation of B cell activation (GO:0050869)3.07615370
47antigen processing and presentation of endogenous antigen (GO:0019883)3.07325104
48positive regulation of B cell activation (GO:0050871)3.07003006
49detection of biotic stimulus (GO:0009595)3.06073081
50interkinetic nuclear migration (GO:0022027)3.05340079
51B cell differentiation (GO:0030183)3.03913774
52mast cell activation (GO:0045576)3.03740008
53positive regulation of B cell proliferation (GO:0030890)3.03739168
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.00914694
55organelle membrane fusion (GO:0090174)3.00580970
56cardiolipin metabolic process (GO:0032048)3.00210540
57regulation of fibroblast apoptotic process (GO:2000269)3.00085798
58negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.98681261
59B cell proliferation (GO:0042100)2.95417304
60negative T cell selection (GO:0043383)2.93973747
61histone mRNA catabolic process (GO:0071044)2.92522944
62myeloid cell activation involved in immune response (GO:0002275)2.90972004
63dosage compensation (GO:0007549)2.90667181
64positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.87186507
65regulation of interleukin-17 production (GO:0032660)2.86867088
66purine deoxyribonucleotide catabolic process (GO:0009155)2.84961679
67cell wall macromolecule metabolic process (GO:0044036)2.84951243
68B cell homeostasis (GO:0001782)2.83226791
69myeloid leukocyte mediated immunity (GO:0002444)2.78971639
70histone H3-K4 trimethylation (GO:0080182)2.77422177
71regulation of interleukin-12 biosynthetic process (GO:0045075)2.77358674
72regulation of non-canonical Wnt signaling pathway (GO:2000050)2.77249954
73interferon-gamma-mediated signaling pathway (GO:0060333)2.77115027
74regulation of B cell apoptotic process (GO:0002902)2.76763513
75positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.76400808
76regulation of germinal center formation (GO:0002634)2.73564283
77protein K11-linked deubiquitination (GO:0035871)2.72640547
78regulation of hypersensitivity (GO:0002883)2.71643444
79regulation of pigment cell differentiation (GO:0050932)2.71230852
80regulation of granulocyte differentiation (GO:0030852)2.69846561
81regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.69845854
82antigen receptor-mediated signaling pathway (GO:0050851)2.69200282
83neutrophil activation (GO:0042119)2.69140062
84negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.68409548
85microglial cell activation (GO:0001774)2.68273966
86modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68079095
87positive regulation by organism of defense response of other organism involved in symbiotic interact2.68079095
88modulation by symbiont of host immune response (GO:0052553)2.68079095
89positive regulation by symbiont of host defense response (GO:0052509)2.68079095
90modulation by symbiont of host defense response (GO:0052031)2.68079095
91modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68079095
92negative regulation of interleukin-12 production (GO:0032695)2.66877343
93T cell selection (GO:0045058)2.66025044
94negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.64266347
95regulation of dendritic cell antigen processing and presentation (GO:0002604)2.62318690
96regulation of antigen processing and presentation (GO:0002577)2.61718311
97negative regulation of cell fate specification (GO:0009996)2.60789939
98response to host immune response (GO:0052572)2.58346599
99response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.58346599
100regulation of mast cell degranulation (GO:0043304)2.57945074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.84175051
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.85280630
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.41874118
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.70080693
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.20058848
6SCL_19346495_ChIP-Seq_HPC-7_Human2.86478323
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.83972318
8RUNX_20019798_ChIP-Seq_JUKART_Human2.74310159
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.67574750
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.59857827
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59256705
12MYB_26560356_Chip-Seq_TH2_Human2.55992991
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48542259
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44187500
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43288658
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37650621
17SPI1_23547873_ChIP-Seq_NB4_Human2.26388844
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25691952
19IGF1R_20145208_ChIP-Seq_DFB_Human2.20344548
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19499982
21VDR_24787735_ChIP-Seq_THP-1_Human2.14386753
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14132555
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13263993
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.09996271
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05986463
26MYB_26560356_Chip-Seq_TH1_Human1.96015301
27GATA3_26560356_Chip-Seq_TH2_Human1.88209215
28VDR_24763502_ChIP-Seq_THP-1_Human1.84213472
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77605176
30GATA3_27048872_Chip-Seq_THYMUS_Human1.73281022
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71158166
32NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.63462662
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.62687826
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.62052654
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61706950
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57221497
37CIITA_25753668_ChIP-Seq_RAJI_Human1.52313374
38SPI1_23127762_ChIP-Seq_K562_Human1.51655180
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45729095
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39997908
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37243372
42MYC_22102868_ChIP-Seq_BL_Human1.36321368
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35271540
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.34627005
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33582491
46RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.32290859
47MAF_26560356_Chip-Seq_TH1_Human1.29306331
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28781407
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26975192
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20215277
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18667415
52VDR_23849224_ChIP-Seq_CD4+_Human1.17353201
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17076670
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16766094
55TAF15_26573619_Chip-Seq_HEK293_Human1.15851097
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15725446
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14364041
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14022147
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13823456
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13515611
61VDR_21846776_ChIP-Seq_THP-1_Human1.13190040
62GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10817367
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.09098595
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06749134
65SMRT_27268052_Chip-Seq_Bcells_Human1.06310023
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05276513
67PU_27001747_Chip-Seq_BMDM_Mouse1.04926758
68ER_23166858_ChIP-Seq_MCF-7_Human1.04297008
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03377024
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.02500347
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02199855
72TCF7_22412390_ChIP-Seq_EML_Mouse1.02161080
73TP53_16413492_ChIP-PET_HCT116_Human0.99002608
74GATA2_21666600_ChIP-Seq_HMVEC_Human0.98371844
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96268830
76FOXP3_21729870_ChIP-Seq_TREG_Human0.95603663
77UTX_26944678_Chip-Seq_JUKART_Human0.94461487
78CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94199937
79PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93280987
80GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92974695
81ELK1_19687146_ChIP-ChIP_HELA_Human0.92358415
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89678088
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88840928
84SALL1_21062744_ChIP-ChIP_HESCs_Human0.88396424
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86914520
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86839109
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.84505742
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83572621
89VDR_22108803_ChIP-Seq_LS180_Human0.83003142
90FLI1_21867929_ChIP-Seq_TH2_Mouse0.82536063
91PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81439679
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80868234
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79452817
94ETS1_22383799_ChIP-Seq_G1ME_Mouse0.79362804
95CBP_20019798_ChIP-Seq_JUKART_Human0.79100367
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79100367
97GATA3_26560356_Chip-Seq_TH1_Human0.78868713
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78827804
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78275511
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.77390194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.79210802
2MP0001800_abnormal_humoral_immune3.26920735
3MP0002138_abnormal_hepatobiliary_system3.17788506
4MP0005671_abnormal_response_to3.07534186
5MP0002009_preneoplasia2.69885543
6MP0005000_abnormal_immune_tolerance2.69821982
7MP0003724_increased_susceptibility_to2.59830203
8MP0000685_abnormal_immune_system2.49308445
9MP0002452_abnormal_antigen_presenting2.44166523
10MP0002723_abnormal_immune_serum2.35680006
11MP0001853_heart_inflammation2.31186216
12MP0002148_abnormal_hypersensitivity_rea2.29869279
13MP0008004_abnormal_stomach_pH2.28224638
14MP0003436_decreased_susceptibility_to2.27033178
15MP0000569_abnormal_digit_pigmentation2.25270793
16MP0001790_abnormal_immune_system2.24656103
17MP0005387_immune_system_phenotype2.24656103
18MP0002420_abnormal_adaptive_immunity2.24037554
19MP0002166_altered_tumor_susceptibility2.21665981
20MP0001819_abnormal_immune_cell2.20712142
21MP0003303_peritoneal_inflammation2.16874581
22MP0009764_decreased_sensitivity_to2.16529575
23MP0002419_abnormal_innate_immunity2.12007456
24MP0002398_abnormal_bone_marrow2.08881111
25MP0003763_abnormal_thymus_physiology2.02284876
26MP0005075_abnormal_melanosome_morpholog2.02234585
27MP0005464_abnormal_platelet_physiology1.91522462
28MP0000716_abnormal_immune_system1.89553648
29MP0005025_abnormal_response_to1.83089910
30MP0004947_skin_inflammation1.81338167
31MP0003787_abnormal_imprinting1.77596173
32MP0002405_respiratory_system_inflammati1.72340005
33MP0000689_abnormal_spleen_morphology1.70091985
34MP0002396_abnormal_hematopoietic_system1.69771576
35MP0002006_tumorigenesis1.66777155
36MP0008057_abnormal_DNA_replication1.66475482
37MP0009278_abnormal_bone_marrow1.65084139
38MP0004808_abnormal_hematopoietic_stem1.57083379
39MP0002429_abnormal_blood_cell1.54577499
40MP0003828_pulmonary_edema1.50873029
41MP0004484_altered_response_of1.50440623
42MP0001545_abnormal_hematopoietic_system1.49399921
43MP0005397_hematopoietic_system_phenotyp1.49399921
44MP0004147_increased_porphyrin_level1.47915409
45MP0002132_abnormal_respiratory_system1.44831559
46MP0004381_abnormal_hair_follicle1.44343958
47MP0000015_abnormal_ear_pigmentation1.43977112
48MP0009785_altered_susceptibility_to1.39839622
49MP0002722_abnormal_immune_system1.39544727
50MP0006292_abnormal_olfactory_placode1.34796755
51MP0008961_abnormal_basal_metabolism1.32843112
52MP0008995_early_reproductive_senescence1.31650986
53MP0005451_abnormal_body_composition1.30805132
54MP0006082_CNS_inflammation1.29906461
55MP0003656_abnormal_erythrocyte_physiolo1.28282846
56MP0003252_abnormal_bile_duct1.26176266
57MP0001845_abnormal_inflammatory_respons1.23665859
58MP0003011_delayed_dark_adaptation1.22720048
59MP0008877_abnormal_DNA_methylation1.17737583
60MP0002877_abnormal_melanocyte_morpholog1.17295754
61MP0010155_abnormal_intestine_physiology1.15559689
62MP0004264_abnormal_extraembryonic_tissu1.15417284
63MP0000703_abnormal_thymus_morphology1.06264361
64MP0005409_darkened_coat_color1.03179171
65MP0003183_abnormal_peptide_metabolism1.02252539
66MP0005310_abnormal_salivary_gland1.01462140
67MP0008469_abnormal_protein_level0.98614553
68MP0009333_abnormal_splenocyte_physiolog0.98363496
69MP0005174_abnormal_tail_pigmentation0.97921424
70MP0001873_stomach_inflammation0.97020900
71MP0003300_gastrointestinal_ulcer0.94446368
72MP0003172_abnormal_lysosome_physiology0.90873155
73MP0005084_abnormal_gallbladder_morpholo0.90574234
74MP0000371_diluted_coat_color0.89975775
75MP0001986_abnormal_taste_sensitivity0.89552450
76MP0001851_eye_inflammation0.88757419
77MP0009765_abnormal_xenobiotic_induced0.87153757
78MP0004883_abnormal_blood_vessel0.87011455
79MP0003806_abnormal_nucleotide_metabolis0.82776414
80MP0002019_abnormal_tumor_incidence0.81139175
81MP0009115_abnormal_fat_cell0.81015835
82MP0003866_abnormal_defecation0.80880620
83MP0009046_muscle_twitch0.76016661
84MP0003045_fibrosis0.75225116
85MP0002332_abnormal_exercise_endurance0.75079681
86MP0000465_gastrointestinal_hemorrhage0.74313239
87MP0001533_abnormal_skeleton_physiology0.70519060
88MP0001501_abnormal_sleep_pattern0.69940098
89MP0009763_increased_sensitivity_to0.69810870
90MP0002928_abnormal_bile_duct0.68554157
91MP0002095_abnormal_skin_pigmentation0.64500228
92MP0001919_abnormal_reproductive_system0.63056072
93MP0000516_abnormal_urinary_system0.62636699
94MP0005367_renal/urinary_system_phenotyp0.62636699
95MP0002163_abnormal_gland_morphology0.62523907
96MP0005266_abnormal_metabolism0.62187044
97MP0008873_increased_physiological_sensi0.61361443
98MP0001663_abnormal_digestive_system0.58970866
99MP0003646_muscle_fatigue0.58495569
100MP0006054_spinal_hemorrhage0.56563486

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.79736398
2Agammaglobulinemia (HP:0004432)4.58718082
3Abnormality of B cell number (HP:0010975)3.91112008
4Mediastinal lymphadenopathy (HP:0100721)3.87004344
5Panhypogammaglobulinemia (HP:0003139)3.86555480
6Autoimmune hemolytic anemia (HP:0001890)3.80202639
7Recurrent fungal infections (HP:0002841)3.68793059
8B lymphocytopenia (HP:0010976)3.64993024
9Meningitis (HP:0001287)3.63847158
10Vasculitis (HP:0002633)3.63619701
11Recurrent viral infections (HP:0004429)3.62634632
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.56284066
13Recurrent bacterial skin infections (HP:0005406)3.51966677
14Stomatitis (HP:0010280)3.48487768
15Recurrent abscess formation (HP:0002722)3.11098887
16Papilloma (HP:0012740)3.05629161
17Verrucae (HP:0200043)3.05629161
18Myositis (HP:0100614)3.04139099
19Autoimmune thrombocytopenia (HP:0001973)3.01910651
20Chronic obstructive pulmonary disease (HP:0006510)2.97629217
21Obstructive lung disease (HP:0006536)2.97629217
22Gingival bleeding (HP:0000225)2.96478236
23Retrobulbar optic neuritis (HP:0100654)2.89784939
24Optic neuritis (HP:0100653)2.89784939
25Increased IgM level (HP:0003496)2.89465118
26Thyroiditis (HP:0100646)2.87935028
27Granulocytopenia (HP:0001913)2.85990443
28Encephalitis (HP:0002383)2.80183645
29Eosinophilia (HP:0001880)2.78863066
30Diastasis recti (HP:0001540)2.76239215
31Cellulitis (HP:0100658)2.75358552
32Neoplasm of the tracheobronchial system (HP:0100552)2.74478030
33Gastrointestinal infarctions (HP:0005244)2.72245970
34Severe combined immunodeficiency (HP:0004430)2.71477529
35Epistaxis (HP:0000421)2.70765250
36Leukocytosis (HP:0001974)2.61807336
37Orchitis (HP:0100796)2.60101579
38Abnormality of the prostate (HP:0008775)2.59615101
39Pulmonary infiltrates (HP:0002113)2.59545051
40Widely spaced teeth (HP:0000687)2.59297655
41Abnormality of eosinophils (HP:0001879)2.48135272
42Arterial thrombosis (HP:0004420)2.41836300
43Abnormality of the pleura (HP:0002103)2.41189936
44Lymphopenia (HP:0001888)2.40983574
45Abnormality of T cells (HP:0002843)2.40851807
46Chest pain (HP:0100749)2.39932109
47Stomach cancer (HP:0012126)2.38660303
48Pustule (HP:0200039)2.36942691
49Clubbing of toes (HP:0100760)2.36900357
50Acute myeloid leukemia (HP:0004808)2.35567493
51Recurrent cutaneous fungal infections (HP:0011370)2.34900152
52Chronic mucocutaneous candidiasis (HP:0002728)2.34900152
53Hemoptysis (HP:0002105)2.31657133
54Urticaria (HP:0001025)2.31424075
55Acute lymphatic leukemia (HP:0006721)2.31069437
56Recurrent skin infections (HP:0001581)2.31044759
57Osteomyelitis (HP:0002754)2.29960408
58Submucous cleft hard palate (HP:0000176)2.27563478
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.26314172
60Neonatal hypoglycemia (HP:0001998)2.25593129
61Alveolar cell carcinoma (HP:0006519)2.24515182
62Skin rash (HP:0000988)2.24169393
63Abnormality of T cell physiology (HP:0011840)2.23914873
64Febrile seizures (HP:0002373)2.20089928
65Neutropenia (HP:0001875)2.20052615
66Abnormality of T cell number (HP:0011839)2.18609414
67Anorexia (HP:0002039)2.18012859
68Abnormality of macrophages (HP:0004311)2.17432795
69Petechiae (HP:0000967)2.15542765
70Colitis (HP:0002583)2.15535789
71Chronic sinusitis (HP:0011109)2.10580975
72Disproportionate short-trunk short stature (HP:0003521)2.09600397
73Amyloidosis (HP:0011034)2.08330329
74Abnormality of the periventricular white matter (HP:0002518)2.06633935
75Prolonged bleeding time (HP:0003010)2.06355551
76Recurrent sinusitis (HP:0011108)2.05275193
77Combined immunodeficiency (HP:0005387)2.04808532
78Eczematoid dermatitis (HP:0000976)1.99570716
79Neurodegeneration (HP:0002180)1.98924543
80Genetic anticipation (HP:0003743)1.94920303
81Hemorrhage of the eye (HP:0011885)1.92650952
82Abnormality of the columella (HP:0009929)1.91741127
83Inflammation of the large intestine (HP:0002037)1.90155684
84Gastrointestinal stroma tumor (HP:0100723)1.89358410
85Increased IgE level (HP:0003212)1.89153232
86Sepsis (HP:0100806)1.88771782
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88739414
88Keratoconjunctivitis sicca (HP:0001097)1.87584209
89Episodic fever (HP:0001954)1.86603822
90Lymphoma (HP:0002665)1.86358024
91IgG deficiency (HP:0004315)1.85341121
92Abnormality of cells of the erythroid lineage (HP:0012130)1.85243921
93IgM deficiency (HP:0002850)1.85200124
94Hypochromic microcytic anemia (HP:0004840)1.85156472
95T lymphocytopenia (HP:0005403)1.85069305
96Gangrene (HP:0100758)1.83486652
97J-shaped sella turcica (HP:0002680)1.82957914
983-Methylglutaconic aciduria (HP:0003535)1.81980080
99Short chin (HP:0000331)1.79638063
100Hypochromic anemia (HP:0001931)1.78257378

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR23.79533806
2RIPK43.36298256
3IRAK23.21438062
4TAOK33.20827881
5KIT2.91400306
6MAP2K32.75732143
7CDK192.71950249
8IRAK12.44853064
9SYK2.31469381
10TEC2.24723484
11TRPM72.15773355
12BTK2.01907801
13PIK3CG2.01343228
14CDK121.99267936
15FRK1.96172096
16MAP4K11.92304133
17RIPK11.91230938
18ITK1.73241143
19MAP3K31.73231963
20IKBKB1.71537594
21MATK1.55131217
22FES1.55057233
23JAK31.46203851
24PIK3CA1.42795788
25IRAK41.41938830
26GRK11.39233508
27CAMK1D1.36730751
28TXK1.36471215
29IKBKE1.36218080
30MKNK21.34843491
31HCK1.27779503
32EIF2AK31.27614428
33CHUK1.24346296
34BLK1.20123058
35MST41.17207379
36FGFR31.16829120
37GRK61.14816485
38ZAK1.11266283
39ZAP701.08539586
40TYK21.07666894
41CDK61.06937261
42LYN1.06473961
43MAP3K141.05584216
44FLT31.04435383
45CSF1R0.97279200
46MAPK110.94580910
47CDK40.94516879
48PRPF4B0.94485209
49LCK0.92343377
50TBK10.90496799
51PIM10.89502110
52NLK0.88981491
53AKT30.88840575
54CAMK1G0.86885402
55TNK20.82853848
56CSK0.81908990
57MARK30.81160828
58CDK30.77014103
59EGFR0.74705964
60HIPK20.70725801
61MAPK120.70608540
62MKNK10.66324562
63TAOK20.66125836
64CDK80.64568293
65JAK20.63772661
66ABL10.60823590
67SGK20.59513571
68MAPK70.55986519
69BRD40.55029188
70CLK10.54830267
71PRKCQ0.54538495
72ABL20.54323990
73STK160.53143015
74FGR0.50332709
75RPS6KB20.50166752
76ERBB20.49382915
77RPS6KA50.47244945
78DYRK1A0.47105087
79YES10.46940907
80JAK10.41540665
81SIK20.40643360
82IGF1R0.38478469
83CHEK20.38461630
84STK40.37693828
85MAP2K20.37268366
86NUAK10.35925630
87MAPK40.34594421
88CDK90.33943352
89BMPR1B0.33770399
90ACVR1B0.33732081
91TGFBR20.32696110
92RPS6KA40.31901274
93MARK20.31797096
94OXSR10.31048569
95PDK10.29844014
96STK100.28361796
97PRKD20.27616748
98MAPK30.25544446
99GRK70.23748037
100AKT10.23070253

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.30067785
2Allograft rejection_Homo sapiens_hsa053303.45799997
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.31156769
4Graft-versus-host disease_Homo sapiens_hsa053323.24825318
5Autoimmune thyroid disease_Homo sapiens_hsa053203.11703251
6Leishmaniasis_Homo sapiens_hsa051402.91230868
7Type I diabetes mellitus_Homo sapiens_hsa049402.61993179
8B cell receptor signaling pathway_Homo sapiens_hsa046622.55945323
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.42206370
10Primary immunodeficiency_Homo sapiens_hsa053402.33714631
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.07192880
12Staphylococcus aureus infection_Homo sapiens_hsa051502.04113709
13Hematopoietic cell lineage_Homo sapiens_hsa046401.86391632
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.86174557
15Osteoclast differentiation_Homo sapiens_hsa043801.72850540
16Toxoplasmosis_Homo sapiens_hsa051451.64883240
17Tuberculosis_Homo sapiens_hsa051521.63757109
18Antigen processing and presentation_Homo sapiens_hsa046121.56484884
19Influenza A_Homo sapiens_hsa051641.50027238
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48835488
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48267880
22Systemic lupus erythematosus_Homo sapiens_hsa053221.41433232
23Viral myocarditis_Homo sapiens_hsa054161.40769914
24Rheumatoid arthritis_Homo sapiens_hsa053231.39523228
25Legionellosis_Homo sapiens_hsa051341.39515129
26T cell receptor signaling pathway_Homo sapiens_hsa046601.38859810
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34607245
28Herpes simplex infection_Homo sapiens_hsa051681.25832496
29Acute myeloid leukemia_Homo sapiens_hsa052211.25188994
30Non-small cell lung cancer_Homo sapiens_hsa052231.23106689
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20948641
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14283312
33Measles_Homo sapiens_hsa051621.13137966
34Hepatitis B_Homo sapiens_hsa051611.07306385
35TNF signaling pathway_Homo sapiens_hsa046681.05648700
36Malaria_Homo sapiens_hsa051441.03876137
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.03496009
38Ribosome_Homo sapiens_hsa030101.01449654
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98486682
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96156770
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94626714
42African trypanosomiasis_Homo sapiens_hsa051430.92152837
43Pancreatic cancer_Homo sapiens_hsa052120.91861563
44Epstein-Barr virus infection_Homo sapiens_hsa051690.88493135
45Chronic myeloid leukemia_Homo sapiens_hsa052200.84629872
46Fanconi anemia pathway_Homo sapiens_hsa034600.80530758
47Phagosome_Homo sapiens_hsa041450.79886154
48Platelet activation_Homo sapiens_hsa046110.79490033
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.76580821
50Other glycan degradation_Homo sapiens_hsa005110.76529506
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75552073
52Chemokine signaling pathway_Homo sapiens_hsa040620.74543478
53RNA degradation_Homo sapiens_hsa030180.74280045
54Regulation of autophagy_Homo sapiens_hsa041400.71639145
55Apoptosis_Homo sapiens_hsa042100.71148888
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70781943
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67242271
58Hepatitis C_Homo sapiens_hsa051600.66855930
59Dorso-ventral axis formation_Homo sapiens_hsa043200.66491638
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66203780
61Homologous recombination_Homo sapiens_hsa034400.64251019
62Viral carcinogenesis_Homo sapiens_hsa052030.60804055
63Spliceosome_Homo sapiens_hsa030400.59016971
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.58756604
65DNA replication_Homo sapiens_hsa030300.57644617
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57456763
67Shigellosis_Homo sapiens_hsa051310.56935045
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56056209
69Pertussis_Homo sapiens_hsa051330.56021487
70HTLV-I infection_Homo sapiens_hsa051660.51443088
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51036722
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.51004603
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50209467
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.48822946
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47891522
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46456834
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45583627
78Phototransduction_Homo sapiens_hsa047440.45519419
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43324825
80Nitrogen metabolism_Homo sapiens_hsa009100.42796912
81Nucleotide excision repair_Homo sapiens_hsa034200.42601196
82FoxO signaling pathway_Homo sapiens_hsa040680.41784426
83Prolactin signaling pathway_Homo sapiens_hsa049170.40544311
84Prostate cancer_Homo sapiens_hsa052150.40318721
85HIF-1 signaling pathway_Homo sapiens_hsa040660.39099353
86Inositol phosphate metabolism_Homo sapiens_hsa005620.38876099
87Insulin resistance_Homo sapiens_hsa049310.38772616
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37664524
89Olfactory transduction_Homo sapiens_hsa047400.37298196
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37173696
91Ether lipid metabolism_Homo sapiens_hsa005650.36413220
92Small cell lung cancer_Homo sapiens_hsa052220.35470906
93VEGF signaling pathway_Homo sapiens_hsa043700.32888340
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.32258923
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31427917
96Amoebiasis_Homo sapiens_hsa051460.28152723
97mTOR signaling pathway_Homo sapiens_hsa041500.24298237
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23827965
99Glioma_Homo sapiens_hsa052140.22062827
100Colorectal cancer_Homo sapiens_hsa052100.21829425

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