RGS19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.94989314
2negative regulation of cell killing (GO:0031342)5.94989314
3ribosomal small subunit assembly (GO:0000028)5.62481153
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.28734876
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.28734876
6modulation by symbiont of host immune response (GO:0052553)5.28734876
7positive regulation by symbiont of host defense response (GO:0052509)5.28734876
8modulation by symbiont of host defense response (GO:0052031)5.28734876
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.28734876
10detection of other organism (GO:0098543)4.92595376
11macrophage activation involved in immune response (GO:0002281)4.90734058
12detection of bacterium (GO:0016045)4.87147831
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.59808785
14DNA deamination (GO:0045006)4.48438893
15neutrophil activation (GO:0042119)4.40097367
16cellular extravasation (GO:0045123)4.27093229
17viral transcription (GO:0019083)4.26405128
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.24911929
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.16494147
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.16494147
21regulation of mast cell degranulation (GO:0043304)4.12369840
22translational termination (GO:0006415)4.06184492
23detection of external biotic stimulus (GO:0098581)4.05547028
24negative regulation of interleukin-12 production (GO:0032695)4.04758245
25granulocyte activation (GO:0036230)4.03255960
26antigen processing and presentation of endogenous antigen (GO:0019883)3.95642023
27regulation of B cell receptor signaling pathway (GO:0050855)3.92958302
28negative regulation of lymphocyte mediated immunity (GO:0002707)3.86846274
29positive regulation of gamma-delta T cell activation (GO:0046645)3.82853062
30regulation of myeloid leukocyte mediated immunity (GO:0002886)3.81257462
31regulation of mast cell activation involved in immune response (GO:0033006)3.76032625
32positive regulation of mast cell activation (GO:0033005)3.71073721
33telomere maintenance via semi-conservative replication (GO:0032201)3.70811166
34negative regulation of phagocytosis (GO:0050765)3.69556722
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.67662825
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.67282593
37response to host immune response (GO:0052572)3.67282593
38ribosomal small subunit biogenesis (GO:0042274)3.66539621
39immunoglobulin mediated immune response (GO:0016064)3.64934609
40regulation of leukocyte degranulation (GO:0043300)3.63800735
41translational elongation (GO:0006414)3.62396742
42DNA strand elongation involved in DNA replication (GO:0006271)3.62334382
43Arp2/3 complex-mediated actin nucleation (GO:0034314)3.60817499
44negative regulation of leukocyte mediated immunity (GO:0002704)3.60685238
45response to interleukin-15 (GO:0070672)3.58884017
46cotranslational protein targeting to membrane (GO:0006613)3.57914548
47detection of biotic stimulus (GO:0009595)3.56567652
48protein targeting to ER (GO:0045047)3.55310368
49response to interferon-beta (GO:0035456)3.54865096
50negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.54656025
51positive thymic T cell selection (GO:0045059)3.52402826
52leukocyte migration involved in inflammatory response (GO:0002523)3.51888730
53detection of molecule of bacterial origin (GO:0032490)3.51365319
54leukocyte aggregation (GO:0070486)3.50504980
55macrophage activation (GO:0042116)3.49824648
56positive regulation of B cell differentiation (GO:0045579)3.49513350
57DNA strand elongation (GO:0022616)3.48685156
58positive regulation of mast cell degranulation (GO:0043306)3.46672776
59positive regulation of mast cell activation involved in immune response (GO:0033008)3.46672776
60microglial cell activation (GO:0001774)3.46488240
61regulation of mast cell activation (GO:0033003)3.46284072
62negative thymic T cell selection (GO:0045060)3.46194439
63regulation of dendritic cell antigen processing and presentation (GO:0002604)3.43632403
64maturation of SSU-rRNA (GO:0030490)3.43274571
65antigen processing and presentation via MHC class Ib (GO:0002475)3.40316801
66protein localization to endoplasmic reticulum (GO:0070972)3.40172131
67negative regulation of T cell mediated immunity (GO:0002710)3.38013879
68negative T cell selection (GO:0043383)3.36931591
69response to muramyl dipeptide (GO:0032495)3.36403426
70establishment of protein localization to endoplasmic reticulum (GO:0072599)3.36016492
71mast cell activation (GO:0045576)3.35738335
72response to host (GO:0075136)3.35737986
73response to host defenses (GO:0052200)3.35737986
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.35737986
75regulation of B cell differentiation (GO:0045577)3.34808937
76cellular response to interleukin-15 (GO:0071350)3.34529965
77negative regulation of erythrocyte differentiation (GO:0045647)3.32691681
78cellular response to zinc ion (GO:0071294)3.32535348
79regulation of T cell tolerance induction (GO:0002664)3.31307161
80telomere maintenance via recombination (GO:0000722)3.31102661
81cellular response to interferon-beta (GO:0035458)3.27590671
82positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.25635739
83viral life cycle (GO:0019058)3.21793119
84regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.21769148
85B cell mediated immunity (GO:0019724)3.21294937
86nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19007541
87regulation of tolerance induction (GO:0002643)3.18134483
88neutrophil activation involved in immune response (GO:0002283)3.17324629
89positive regulation of antigen processing and presentation (GO:0002579)3.15432367
90respiratory burst (GO:0045730)3.13068978
91regulation of antigen processing and presentation (GO:0002577)3.13016499
92positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.12925730
93cellular protein complex disassembly (GO:0043624)3.08483035
94translational initiation (GO:0006413)3.06817737
95defense response to protozoan (GO:0042832)3.06234397
96regulation of regulated secretory pathway (GO:1903305)3.05411915
97T cell selection (GO:0045058)3.04307971
98germinal center formation (GO:0002467)3.03094774
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.02863496
100negative regulation of T-helper cell differentiation (GO:0045623)3.02863496
101regulation of T-helper 2 cell differentiation (GO:0045628)3.02534742
102B cell receptor signaling pathway (GO:0050853)3.01133562
103mitotic recombination (GO:0006312)2.99123767
104positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.97174141
105regulation of alpha-beta T cell proliferation (GO:0046640)2.93610904
106negative regulation of innate immune response (GO:0045824)2.93492979
107lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93301327
108production of molecular mediator involved in inflammatory response (GO:0002532)2.92756690
109positive regulation of T cell mediated cytotoxicity (GO:0001916)2.92619433
110response to protozoan (GO:0001562)2.91127806
111regulation of T cell mediated cytotoxicity (GO:0001914)2.90434126
112regulation of natural killer cell mediated immunity (GO:0002715)2.89878129
113regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.89878129
114DNA unwinding involved in DNA replication (GO:0006268)2.88771528
115platelet dense granule organization (GO:0060155)2.85089341
116mature B cell differentiation involved in immune response (GO:0002313)2.82659546
117DNA replication initiation (GO:0006270)2.82040858
118cellular response to type I interferon (GO:0071357)2.81158029
119type I interferon signaling pathway (GO:0060337)2.81158029
120response to type I interferon (GO:0034340)2.78552075
121telomere maintenance via telomere lengthening (GO:0010833)2.75280464
122regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.74741527
123response to peptidoglycan (GO:0032494)2.74565257
124myeloid dendritic cell activation (GO:0001773)2.73588190
125protein complex disassembly (GO:0043241)2.73299648
126definitive hemopoiesis (GO:0060216)2.69128948
127ribosomal large subunit biogenesis (GO:0042273)2.67691556
128positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.66891907
129mast cell degranulation (GO:0043303)2.64978002
130mast cell activation involved in immune response (GO:0002279)2.64978002
131nucleotide-excision repair, DNA gap filling (GO:0006297)2.64085061
132NIK/NF-kappaB signaling (GO:0038061)2.63064610
133neutrophil mediated immunity (GO:0002446)2.60655134
134response to interferon-alpha (GO:0035455)2.59985085
135sequestering of actin monomers (GO:0042989)2.59400533
136T cell homeostasis (GO:0043029)2.58877149
137regulation of gamma-delta T cell differentiation (GO:0045586)2.58079886
138formation of translation preinitiation complex (GO:0001731)2.56871157
139actin nucleation (GO:0045010)2.56296786
140mature B cell differentiation (GO:0002335)2.56190131
141macromolecular complex disassembly (GO:0032984)2.55493766
142interferon-gamma-mediated signaling pathway (GO:0060333)2.55114615
143regulation of T cell receptor signaling pathway (GO:0050856)2.55061978
144nuclear-transcribed mRNA catabolic process (GO:0000956)2.54955193
145interferon-gamma production (GO:0032609)2.54898638
146pseudouridine synthesis (GO:0001522)2.52631733
147regulation of interferon-beta biosynthetic process (GO:0045357)2.52369134
148ribonucleoprotein complex biogenesis (GO:0022613)2.52110043
149antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.51991010
150antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.51691835
151deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.51599391
152megakaryocyte development (GO:0035855)2.51487187
153positive regulation of lamellipodium assembly (GO:0010592)2.47672120
154positive regulation of interferon-alpha production (GO:0032727)2.45904354
155mRNA catabolic process (GO:0006402)2.45531680
156regulation of gamma-delta T cell activation (GO:0046643)2.44753402
157lymphoid progenitor cell differentiation (GO:0002320)2.44160950
158leukocyte degranulation (GO:0043299)2.44033283
159macrophage differentiation (GO:0030225)2.43359868
160endosome to melanosome transport (GO:0035646)2.41461175
161endosome to pigment granule transport (GO:0043485)2.41461175
162necroptotic process (GO:0070266)2.40881513
163T cell migration (GO:0072678)2.40204683
164RNA catabolic process (GO:0006401)2.37625920
165myeloid cell activation involved in immune response (GO:0002275)2.37248204
166IMP metabolic process (GO:0046040)2.36818538
167regulation of necroptotic process (GO:0060544)2.36435080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.04147374
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.65630227
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26061825
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.17315084
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.16333426
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01154871
7SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.91513286
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.81709209
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.81629236
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72906128
11SCL_19346495_ChIP-Seq_HPC-7_Human2.56939511
12FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.48502515
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45586131
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43953676
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.42345340
16MYC_22102868_ChIP-Seq_BL_Human2.39635055
17TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.35092875
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.32497862
19VDR_21846776_ChIP-Seq_THP-1_Human2.32039207
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28884161
21* SPI1_23547873_ChIP-Seq_NB4_Human2.28466184
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.28321938
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.27879397
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26079554
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.18895378
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17258423
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.14341570
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.07360689
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05622861
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05539773
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04494699
32* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01738650
33SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.01190012
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95901968
35VDR_23849224_ChIP-Seq_CD4+_Human1.92873369
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.90046748
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89058670
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.86999822
39MYB_26560356_Chip-Seq_TH2_Human1.86505042
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85871770
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85243565
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.84389428
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.83351448
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78818059
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.77757612
46* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77514719
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77231437
48FOXP3_21729870_ChIP-Seq_TREG_Human1.76574104
49* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76405794
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74780207
51VDR_24763502_ChIP-Seq_THP-1_Human1.74703768
52* MAF_26560356_Chip-Seq_TH1_Human1.71981420
53KDM2B_26808549_Chip-Seq_DND41_Human1.71849270
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.71499285
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.71238019
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71024947
57XRN2_22483619_ChIP-Seq_HELA_Human1.68491684
58LXR_22292898_ChIP-Seq_THP-1_Human1.67025849
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.64767992
60* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60261439
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.59229676
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.58071999
63CIITA_25753668_ChIP-Seq_RAJI_Human1.57206527
64* MYB_26560356_Chip-Seq_TH1_Human1.56896356
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55844754
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55358257
67UTX_26944678_Chip-Seq_JUKART_Human1.53731614
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52551106
69* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50981816
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50902417
71STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.48262709
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47949839
73BCL6_27268052_Chip-Seq_Bcells_Human1.44619658
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44034108
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42661300
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42233901
77* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40737434
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39632042
79* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39476610
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38549581
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.37641998
82DCP1A_22483619_ChIP-Seq_HELA_Human1.37329646
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.37189208
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36724383
85ELK1_19687146_ChIP-ChIP_HELA_Human1.35726661
86GABP_19822575_ChIP-Seq_HepG2_Human1.34036125
87VDR_24787735_ChIP-Seq_THP-1_Human1.33593830
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33560368
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32612533
90* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30636066
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29665785
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29437262
93BCOR_27268052_Chip-Seq_Bcells_Human1.29364804
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.28345966
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27014316
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26575343
97GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25860132
98TTF2_22483619_ChIP-Seq_HELA_Human1.25604020
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.24507787
100GATA1_22025678_ChIP-Seq_K562_Human1.24401315
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22603581
102RUNX_20019798_ChIP-Seq_JUKART_Human1.21106272
103* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20948104
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18925383
105STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16425275
106MAF_26560356_Chip-Seq_TH2_Human1.16355067
107E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15615752
108GATA3_26560356_Chip-Seq_TH2_Human1.14540606
109THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12380482
110* SPI1_23127762_ChIP-Seq_K562_Human1.11786395
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11663958
112TCF7_22412390_ChIP-Seq_EML_Mouse1.11488025
113CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08528519
114VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08430543
115P68_20966046_ChIP-Seq_HELA_Human1.07233672
116NCOR1_26117541_ChIP-Seq_K562_Human1.06447107
117MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06144832
118TFEB_21752829_ChIP-Seq_HELA_Human1.05757931
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.05437958
120CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05191572
121SPI1_20517297_ChIP-Seq_HL60_Human1.04682220
122ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04109859
123GATA1_19941826_ChIP-Seq_K562_Human1.03932461
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03813502
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02320872
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01940450
127RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01855304
128SA1_27219007_Chip-Seq_ERYTHROID_Human1.01484772
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99718156
130YY1_21170310_ChIP-Seq_MESCs_Mouse0.99454248
131PU_27001747_Chip-Seq_BMDM_Mouse0.99177528
132* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98233199
133FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97049107
134CTCF_26484167_Chip-Seq_Bcells_Mouse0.96941695
135* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96572329
136SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96189604
137GATA3_27048872_Chip-Seq_THYMUS_Human0.92409384
138MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91511196
139* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91217528
140SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91003254
141CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90807546
142SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90374505
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89081357
144RACK7_27058665_Chip-Seq_MCF-7_Human0.87919708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.39791667
2MP0002396_abnormal_hematopoietic_system3.73986943
3MP0009785_altered_susceptibility_to3.15860223
4MP0005671_abnormal_response_to3.15536556
5MP0000685_abnormal_immune_system2.97558315
6MP0003436_decreased_susceptibility_to2.86198507
7MP0003763_abnormal_thymus_physiology2.78532744
8MP0001800_abnormal_humoral_immune2.76773717
9MP0005025_abnormal_response_to2.64445434
10MP0005000_abnormal_immune_tolerance2.61773685
11MP0002148_abnormal_hypersensitivity_rea2.59578195
12MP0002452_abnormal_antigen_presenting2.58197342
13MP0002420_abnormal_adaptive_immunity2.53774870
14MP0001819_abnormal_immune_cell2.50775357
15MP0002398_abnormal_bone_marrow2.48391618
16MP0002419_abnormal_innate_immunity2.45035439
17MP0002723_abnormal_immune_serum2.44738704
18MP0002166_altered_tumor_susceptibility2.41583490
19MP0004808_abnormal_hematopoietic_stem2.41508489
20MP0005464_abnormal_platelet_physiology2.38665115
21MP0005387_immune_system_phenotype2.32919131
22MP0001790_abnormal_immune_system2.32919131
23MP0003693_abnormal_embryo_hatching2.29013631
24MP0000716_abnormal_immune_system2.15870385
25MP0009333_abnormal_splenocyte_physiolog2.13738003
26MP0005174_abnormal_tail_pigmentation2.12752836
27MP0000689_abnormal_spleen_morphology2.10749424
28MP0002006_tumorigenesis2.07086344
29MP0002722_abnormal_immune_system2.02895735
30MP0003724_increased_susceptibility_to2.01782248
31MP0001853_heart_inflammation1.99976458
32MP0001545_abnormal_hematopoietic_system1.97644639
33MP0005397_hematopoietic_system_phenotyp1.97644639
34MP0002405_respiratory_system_inflammati1.97134107
35MP0002429_abnormal_blood_cell1.94624980
36MP0010094_abnormal_chromosome_stability1.92178555
37MP0000490_abnormal_crypts_of1.82742970
38MP0005075_abnormal_melanosome_morpholog1.80731343
39MP0008260_abnormal_autophagy1.73900397
40MP0010155_abnormal_intestine_physiology1.73818784
41MP0003077_abnormal_cell_cycle1.72799420
42MP0008007_abnormal_cellular_replicative1.70767453
43MP0003303_peritoneal_inflammation1.66897651
44MP0000465_gastrointestinal_hemorrhage1.65166671
45MP0008057_abnormal_DNA_replication1.63679842
46MP0000703_abnormal_thymus_morphology1.63333747
47MP0001845_abnormal_inflammatory_respons1.60453563
48MP0001873_stomach_inflammation1.60166343
49MP0006054_spinal_hemorrhage1.53245007
50MP0000858_altered_metastatic_potential1.52785517
51MP0004957_abnormal_blastocyst_morpholog1.49727760
52MP0008058_abnormal_DNA_repair1.49295897
53MP0003806_abnormal_nucleotide_metabolis1.44086982
54MP0006082_CNS_inflammation1.43738649
55MP0002095_abnormal_skin_pigmentation1.40649265
56MP0000015_abnormal_ear_pigmentation1.35178595
57MP0003111_abnormal_nucleus_morphology1.33278714
58MP0003172_abnormal_lysosome_physiology1.31913985
59MP0001533_abnormal_skeleton_physiology1.31613616
60MP0002019_abnormal_tumor_incidence1.31253771
61MP0000343_altered_response_to1.28053724
62MP0003075_altered_response_to1.27057783
63MP0004510_myositis1.26622249
64MP0003866_abnormal_defecation1.26619051
65MP0008469_abnormal_protein_level1.23815105
66MP0005451_abnormal_body_composition1.20930485
67MP0002933_joint_inflammation1.19768748
68MP0005058_abnormal_lysosome_morphology1.17760251
69MP0009278_abnormal_bone_marrow1.16281226
70MP0004381_abnormal_hair_follicle1.15295938
71MP0002277_abnormal_respiratory_mucosa1.13831881
72MP0004947_skin_inflammation1.12276787
73MP0010352_gastrointestinal_tract_polyps1.10021044
74MP0004883_abnormal_blood_vessel1.08425971
75MP0005166_decreased_susceptibility_to1.00475653
76MP0000313_abnormal_cell_death0.96650150
77MP0003448_altered_tumor_morphology0.94123918
78MP0005164_abnormal_response_to0.88841738
79MP0003186_abnormal_redox_activity0.87333032
80MP0005310_abnormal_salivary_gland0.87305342
81MP0002132_abnormal_respiratory_system0.86046240
82MP0009379_abnormal_foot_pigmentation0.85958273
83MP0001986_abnormal_taste_sensitivity0.85890741
84MP0003300_gastrointestinal_ulcer0.83093274
85MP0000604_amyloidosis0.81632174
86MP0002138_abnormal_hepatobiliary_system0.80724927
87MP0009840_abnormal_foam_cell0.79252986
88MP0003183_abnormal_peptide_metabolism0.78864157
89MP0003943_abnormal_hepatobiliary_system0.78464654
90MP0003279_aneurysm0.78068868
91MP0000350_abnormal_cell_proliferation0.76808189
92MP0005023_abnormal_wound_healing0.74478704
93MP0010307_abnormal_tumor_latency0.74107359
94MP0003690_abnormal_glial_cell0.73046154
95MP0003786_premature_aging0.71753754
96MP0009765_abnormal_xenobiotic_induced0.66511236
97MP0008004_abnormal_stomach_pH0.66275866
98MP0003828_pulmonary_edema0.66184457
99MP0009763_increased_sensitivity_to0.66035443
100MP0000371_diluted_coat_color0.65866511
101MP0009764_decreased_sensitivity_to0.64794460
102MP0001663_abnormal_digestive_system0.63883880
103MP0008874_decreased_physiological_sensi0.63807910
104MP0001851_eye_inflammation0.63577068
105MP0005390_skeleton_phenotype0.62605728
106MP0000249_abnormal_blood_vessel0.58773291
107MP0005319_abnormal_enzyme/_coenzyme0.56352856
108MP0003191_abnormal_cellular_cholesterol0.55600089
109MP0000477_abnormal_intestine_morphology0.54877985
110MP0000358_abnormal_cell_content/0.54706538
111MP0002075_abnormal_coat/hair_pigmentati0.54657310
112MP0008932_abnormal_embryonic_tissue0.54583454
113MP0008873_increased_physiological_sensi0.54052036
114MP0003656_abnormal_erythrocyte_physiolo0.53961774
115MP0004858_abnormal_nervous_system0.51509686
116MP0002998_abnormal_bone_remodeling0.51349683
117MP0002009_preneoplasia0.49852713
118MP0003795_abnormal_bone_structure0.48973802
119MP0004147_increased_porphyrin_level0.48592976
120MP0003045_fibrosis0.47385742
121MP0005084_abnormal_gallbladder_morpholo0.46581371
122MP0002693_abnormal_pancreas_physiology0.45607442
123MP0000609_abnormal_liver_physiology0.45069323
124MP0005381_digestive/alimentary_phenotyp0.43459223
125MP0005076_abnormal_cell_differentiation0.39708734
126MP0005376_homeostasis/metabolism_phenot0.38587939

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.34689209
2Recurrent abscess formation (HP:0002722)5.20511477
3Myositis (HP:0100614)4.74302096
4Thrombocytosis (HP:0001894)4.68530139
5Recurrent bacterial skin infections (HP:0005406)4.65597656
6IgM deficiency (HP:0002850)4.16328744
7Eczematoid dermatitis (HP:0000976)4.09946112
8Gastrointestinal infarctions (HP:0005244)3.80530071
9Aplastic anemia (HP:0001915)3.71575618
10Chronic otitis media (HP:0000389)3.68946776
11Increased IgE level (HP:0003212)3.54774647
12Reticulocytopenia (HP:0001896)3.52569880
13Abnormality of cells of the erythroid lineage (HP:0012130)3.50781791
14Abnormal number of erythroid precursors (HP:0012131)3.49775520
15Urticaria (HP:0001025)3.45799732
16Recurrent viral infections (HP:0004429)3.43240037
17Petechiae (HP:0000967)3.38356976
18Recurrent fungal infections (HP:0002841)3.38280160
19Recurrent bronchitis (HP:0002837)3.26985179
20Recurrent skin infections (HP:0001581)3.26382182
21Meningitis (HP:0001287)3.22940014
22Chronic obstructive pulmonary disease (HP:0006510)3.14625635
23Obstructive lung disease (HP:0006536)3.14625635
24Panhypogammaglobulinemia (HP:0003139)3.13292416
25Mediastinal lymphadenopathy (HP:0100721)3.12757719
26Abnormality of T cell physiology (HP:0011840)3.04280364
27Cellulitis (HP:0100658)3.01634547
28Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.99982010
29Abnormality of macrophages (HP:0004311)2.92572171
30Chronic mucocutaneous candidiasis (HP:0002728)2.89744273
31Recurrent cutaneous fungal infections (HP:0011370)2.89744273
32Orchitis (HP:0100796)2.88381680
33Keratoconjunctivitis (HP:0001096)2.88100725
34Abnormality of T cells (HP:0002843)2.87375713
35Increased IgM level (HP:0003496)2.86554281
36Hypochromic microcytic anemia (HP:0004840)2.85180902
37Abnormality of B cell number (HP:0010975)2.80653542
38B lymphocytopenia (HP:0010976)2.80653542
39Agammaglobulinemia (HP:0004432)2.79375109
40Abnormality of liposaccharide metabolism (HP:0010968)2.77533730
41Abnormality of glycosphingolipid metabolism (HP:0004343)2.77533730
42Abnormality of glycolipid metabolism (HP:0010969)2.77533730
43Anorexia (HP:0002039)2.75211370
44Hypochromic anemia (HP:0001931)2.74316170
45IgG deficiency (HP:0004315)2.72972467
46Prolonged bleeding time (HP:0003010)2.72267844
47Lymphopenia (HP:0001888)2.70839471
48Vasculitis (HP:0002633)2.68200600
49Type I transferrin isoform profile (HP:0003642)2.67552579
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.66249756
51Amyloidosis (HP:0011034)2.65734097
52Optic neuritis (HP:0100653)2.64401434
53Retrobulbar optic neuritis (HP:0100654)2.64401434
54Reduced antithrombin III activity (HP:0001976)2.63863022
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.60600691
56Recurrent gram-negative bacterial infections (HP:0005420)2.59951432
57Gingival bleeding (HP:0000225)2.59763300
58Episodic fever (HP:0001954)2.58660403
59Agnosia (HP:0010524)2.58015855
60Abnormality of the prostate (HP:0008775)2.57532615
61Colitis (HP:0002583)2.53897421
62Lymphoma (HP:0002665)2.48763853
63Pulmonary embolism (HP:0002204)2.48289684
64Thyroiditis (HP:0100646)2.48203763
65Purpura (HP:0000979)2.47866504
66Increased cerebral lipofuscin (HP:0011813)2.45875441
67Sepsis (HP:0100806)2.45639511
68Hepatosplenomegaly (HP:0001433)2.44580074
69Arterial thrombosis (HP:0004420)2.44383413
70Granulocytopenia (HP:0001913)2.39957925
71Leukocytosis (HP:0001974)2.37373985
72Epistaxis (HP:0000421)2.35402505
73Interstitial pulmonary disease (HP:0006530)2.34256036
74Severe combined immunodeficiency (HP:0004430)2.33845974
75Pallor (HP:0000980)2.32433433
76Pustule (HP:0200039)2.31322681
77Increased serum ferritin (HP:0003281)2.30076540
78T lymphocytopenia (HP:0005403)2.27816525
79Gastrointestinal stroma tumor (HP:0100723)2.26918477
80Loss of speech (HP:0002371)2.26163648
81Abnormality of T cell number (HP:0011839)2.24959424
82Hemoptysis (HP:0002105)2.24737388
83Periodontitis (HP:0000704)2.23454407
84Eosinophilia (HP:0001880)2.23376148
85Nasal polyposis (HP:0100582)2.22424270
86Encephalitis (HP:0002383)2.20320603
87Abnormality of eosinophils (HP:0001879)2.19953292
88Disinhibition (HP:0000734)2.19260639
89Poikiloderma (HP:0001029)2.18785049
90Hypergammaglobulinemia (HP:0010702)2.17863924
91Spontaneous hematomas (HP:0007420)2.17530348
92Autoimmune thrombocytopenia (HP:0001973)2.17506383
93Gastrointestinal inflammation (HP:0004386)2.17270291
94Combined immunodeficiency (HP:0005387)2.17017984
95Recurrent pneumonia (HP:0006532)2.16627593
96Gangrene (HP:0100758)2.16155083
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15893626
98Abnormal protein N-linked glycosylation (HP:0012347)2.15893626
99Abnormal protein glycosylation (HP:0012346)2.15893626
100Abnormal glycosylation (HP:0012345)2.15893626
101Microcytic anemia (HP:0001935)2.15662119
102Stomatitis (HP:0010280)2.15106741
103Acute hepatic failure (HP:0006554)2.15060471
104Inflammation of the large intestine (HP:0002037)2.14453371
105Vacuolated lymphocytes (HP:0001922)2.13262524
106Glomerulopathy (HP:0100820)2.13252599
107Hypertensive crisis (HP:0100735)2.12339476
108Peritonitis (HP:0002586)2.11826055
109Abnormality of the nasal mucosa (HP:0000433)2.11181223
110Osteomyelitis (HP:0002754)2.11166480
111Dysostosis multiplex (HP:0000943)2.11118589
112Birth length less than 3rd percentile (HP:0003561)2.10749056
113Pulmonary fibrosis (HP:0002206)2.07865704
114Acute myeloid leukemia (HP:0004808)2.07724300
115Abnormality of iron homeostasis (HP:0011031)2.06589004
116Amaurosis fugax (HP:0100576)2.06070197
117Recurrent lower respiratory tract infections (HP:0002783)2.05179238
118Myelodysplasia (HP:0002863)2.02351660
119Recurrent sinusitis (HP:0011108)2.02140756
120Abnormality of the peritoneum (HP:0002585)2.02005211
121Keratoconjunctivitis sicca (HP:0001097)2.01500474
122Hypoplasia of the thymus (HP:0000778)2.01019566
12311 pairs of ribs (HP:0000878)2.00133640
124Basal ganglia calcification (HP:0002135)1.99340604
125Poor head control (HP:0002421)1.98772686
126Pulmonary infiltrates (HP:0002113)1.98660063
127Gingivitis (HP:0000230)1.97665192
128Skin ulcer (HP:0200042)1.96328978
129Macrocytic anemia (HP:0001972)1.95822866
130Increased neuronal autofluorescent lipopigment (HP:0002074)1.95475425
131Skin rash (HP:0000988)1.94985798
132Papilloma (HP:0012740)1.94916482
133Verrucae (HP:0200043)1.94916482
134Autoimmune hemolytic anemia (HP:0001890)1.94472144
135Chest pain (HP:0100749)1.93174227
136Abnormality of the pleura (HP:0002103)1.92014058
137Abnormal platelet function (HP:0011869)1.91257984
138Upper motor neuron abnormality (HP:0002127)1.90974763
139Systemic lupus erythematosus (HP:0002725)1.89888324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.13168251
2KIT3.43278512
3NME22.77110653
4TXK2.56449116
5IRAK42.56125130
6STK162.52566234
7BLK2.52143623
8FLT32.51406331
9TEC2.44860577
10TNK22.30578683
11CSF1R2.25864361
12BTK2.17797686
13PRPF4B2.12197881
14ZAP702.12001933
15MAP3K122.04907182
16TYK22.02962455
17JAK31.98195902
18WEE11.95770098
19TBK11.90326471
20MAP3K31.77692266
21ACVR1B1.74844753
22IKBKE1.71949424
23PIM21.69669475
24SYK1.66460010
25KDR1.60750805
26TESK21.53693189
27TAOK11.52594543
28EPHB11.50731485
29EIF2AK31.46381042
30TGFBR11.44945207
31MAP2K31.42782371
32RPS6KA41.42329093
33VRK11.38548938
34FGR1.36572631
35MAP3K131.33553246
36CDC71.33168537
37EIF2AK11.32362103
38BUB11.31133140
39MAP3K141.26480026
40BCKDK1.19814492
41IKBKB1.17729150
42ERN11.17317625
43LYN1.17137687
44LRRK21.16474805
45BRSK21.16345484
46MAP3K11.16135457
47TAOK21.16066754
48EEF2K1.15257719
49LCK1.15092916
50STK101.14140223
51CLK11.13442557
52JAK21.08959877
53RIPK41.07513827
54MARK31.06437070
55CCNB11.04964123
56SCYL21.04857302
57FES1.03943118
58MATK1.03672171
59ITK0.99572258
60PIM10.96364302
61HCK0.96258667
62TRIB30.95541847
63NLK0.94017352
64SMG10.92694084
65TGFBR20.91972924
66PRKD20.88375788
67GRK60.88321854
68PKN20.87154661
69CDK80.86657286
70ADRBK20.85418045
71TNIK0.85354482
72PDK10.83887367
73BMPR20.82987342
74MAP3K110.82615216
75RPS6KB20.82319785
76CAMKK20.81327867
77CDK70.77680866
78MKNK10.77455253
79CDK190.77213947
80ATR0.77151695
81PASK0.77036289
82IRAK30.76155308
83MAPK120.75329432
84NEK20.73015504
85SIK30.71952518
86PDPK10.71606253
87YES10.70468593
88DAPK10.70152623
89PAK40.70087329
90MARK20.69044043
91MYLK0.68204545
92PTK60.67559463
93CDK40.67188755
94JAK10.65835710
95MAP3K60.65591371
96FGFR40.65346925
97DYRK30.63759445
98TLK10.63583125
99TESK10.63170743
100FYN0.63069495
101TSSK60.63028814
102CSK0.62755289
103KSR20.61837285
104PRKCQ0.61363042
105RPS6KA60.58949892
106IRAK20.58586770
107SRPK10.56514735
108MAP3K100.56181298
109MAP3K80.54716834
110GRK70.54662407
111ILK0.54541819
112MAP2K20.53389913
113IRAK10.53198030
114MAPK70.50991074
115STK40.50560811
116RPS6KC10.49877816
117RPS6KL10.49877816
118TAOK30.49412827
119SIK20.48833361
120CDC42BPA0.48511847
121PTK2B0.48316659
122MAPKAPK20.48287243
123SIK10.46803385
124FGFR30.46722860
125NEK90.46490169
126MAP3K50.46010457
127AURKB0.45184470
128MAPK40.43646549
129HIPK20.43035489
130BRSK10.42473176
131RAF10.41204974
132PRKG20.40997831
133EIF2AK20.40494479
134PIK3CG0.40149304
135MAPKAPK30.39687072
136CHUK0.38328751
137PRKCD0.36762271
138PLK10.36428054
139MAP2K60.36152519
140MAP2K40.35320581
141MAP3K70.35041716
142ARAF0.34201256
143RPS6KA20.33865542
144MOS0.33445842
145STK110.33276351
146CAMKK10.31397299
147DYRK1B0.29478967
148MAPK110.29265595
149ABL10.28771990
150PRKCH0.27267518

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.04112789
2Ribosome_Homo sapiens_hsa030103.56179556
3Mismatch repair_Homo sapiens_hsa034303.03045967
4Autoimmune thyroid disease_Homo sapiens_hsa053202.90454907
5Primary immunodeficiency_Homo sapiens_hsa053402.82155881
6Base excision repair_Homo sapiens_hsa034102.52415487
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27061322
8Homologous recombination_Homo sapiens_hsa034402.18680218
9Proteasome_Homo sapiens_hsa030502.18295116
10Leishmaniasis_Homo sapiens_hsa051402.16272884
11Spliceosome_Homo sapiens_hsa030401.91848467
12Antigen processing and presentation_Homo sapiens_hsa046121.91367522
13Nucleotide excision repair_Homo sapiens_hsa034201.90635514
14Measles_Homo sapiens_hsa051621.76882128
15Pyrimidine metabolism_Homo sapiens_hsa002401.75086368
16Non-homologous end-joining_Homo sapiens_hsa034501.73925788
17RNA polymerase_Homo sapiens_hsa030201.73663444
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.70189136
19Hematopoietic cell lineage_Homo sapiens_hsa046401.66392842
20B cell receptor signaling pathway_Homo sapiens_hsa046621.65646392
21Herpes simplex infection_Homo sapiens_hsa051681.63031167
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60896919
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60504670
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58496657
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.56761268
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50973293
27Legionellosis_Homo sapiens_hsa051341.42920765
28Osteoclast differentiation_Homo sapiens_hsa043801.38199793
29Cell cycle_Homo sapiens_hsa041101.36615560
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28193174
31Shigellosis_Homo sapiens_hsa051311.26542406
32Other glycan degradation_Homo sapiens_hsa005111.23844286
33RNA transport_Homo sapiens_hsa030131.20401554
34Allograft rejection_Homo sapiens_hsa053301.19567129
35Pertussis_Homo sapiens_hsa051331.17669089
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13682263
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.13310464
38RNA degradation_Homo sapiens_hsa030181.13006764
39Fanconi anemia pathway_Homo sapiens_hsa034601.12560314
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11904937
41Protein export_Homo sapiens_hsa030601.11892038
42Epstein-Barr virus infection_Homo sapiens_hsa051691.09530304
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08262104
44N-Glycan biosynthesis_Homo sapiens_hsa005101.06995441
45p53 signaling pathway_Homo sapiens_hsa041151.06880824
46Influenza A_Homo sapiens_hsa051641.06707638
47African trypanosomiasis_Homo sapiens_hsa051431.05419080
48Hepatitis B_Homo sapiens_hsa051611.05010482
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02742808
50One carbon pool by folate_Homo sapiens_hsa006701.01743910
51Malaria_Homo sapiens_hsa051441.00238490
52Asthma_Homo sapiens_hsa053100.99714991
53Apoptosis_Homo sapiens_hsa042100.98941265
54Tuberculosis_Homo sapiens_hsa051520.98743876
55Acute myeloid leukemia_Homo sapiens_hsa052210.96427750
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95917269
57T cell receptor signaling pathway_Homo sapiens_hsa046600.95046044
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.94006435
59Graft-versus-host disease_Homo sapiens_hsa053320.93748067
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93380747
61Non-small cell lung cancer_Homo sapiens_hsa052230.93346656
62Toxoplasmosis_Homo sapiens_hsa051450.92195696
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91882777
64Viral myocarditis_Homo sapiens_hsa054160.91274763
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89155931
66Platelet activation_Homo sapiens_hsa046110.85936525
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.84140045
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83119730
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82891307
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81834491
71Purine metabolism_Homo sapiens_hsa002300.79746776
72Salmonella infection_Homo sapiens_hsa051320.78660808
73Staphylococcus aureus infection_Homo sapiens_hsa051500.77796967
74VEGF signaling pathway_Homo sapiens_hsa043700.76360437
75Viral carcinogenesis_Homo sapiens_hsa052030.75949384
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75032867
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71828874
78Chemokine signaling pathway_Homo sapiens_hsa040620.71175373
79HTLV-I infection_Homo sapiens_hsa051660.71008412
80Basal transcription factors_Homo sapiens_hsa030220.70146460
81Endocytosis_Homo sapiens_hsa041440.69627796
82Pentose phosphate pathway_Homo sapiens_hsa000300.69352996
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67892199
84TNF signaling pathway_Homo sapiens_hsa046680.64549504
85Systemic lupus erythematosus_Homo sapiens_hsa053220.64313989
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61103884
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59625854
88Pancreatic cancer_Homo sapiens_hsa052120.57241890
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.55604226
90Regulation of autophagy_Homo sapiens_hsa041400.55093237
91Caffeine metabolism_Homo sapiens_hsa002320.54963997
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54841747
93Thyroid cancer_Homo sapiens_hsa052160.54002391
94Notch signaling pathway_Homo sapiens_hsa043300.53441839
95Lysosome_Homo sapiens_hsa041420.52911218
96Chronic myeloid leukemia_Homo sapiens_hsa052200.52541707
97Prolactin signaling pathway_Homo sapiens_hsa049170.49846206
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49239652
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49084013
100Phagosome_Homo sapiens_hsa041450.48578838
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48168763
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.47116455
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.45776069
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.44311389
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43801655
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42672142
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.42060625
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41511413
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41093231
110Renal cell carcinoma_Homo sapiens_hsa052110.40462695
111Small cell lung cancer_Homo sapiens_hsa052220.39681290
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38910533
113Hepatitis C_Homo sapiens_hsa051600.38882714
114Colorectal cancer_Homo sapiens_hsa052100.38562969
115Amoebiasis_Homo sapiens_hsa051460.38322048
116Type I diabetes mellitus_Homo sapiens_hsa049400.37995354
117Rheumatoid arthritis_Homo sapiens_hsa053230.37978514
118Folate biosynthesis_Homo sapiens_hsa007900.36863500
119Arachidonic acid metabolism_Homo sapiens_hsa005900.34745210
120Collecting duct acid secretion_Homo sapiens_hsa049660.32892451
121HIF-1 signaling pathway_Homo sapiens_hsa040660.32060750
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30593765
123Insulin resistance_Homo sapiens_hsa049310.29682146
124GnRH signaling pathway_Homo sapiens_hsa049120.28679885
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28057628
126Choline metabolism in cancer_Homo sapiens_hsa052310.27812616
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26857198
128MAPK signaling pathway_Homo sapiens_hsa040100.26203792
129FoxO signaling pathway_Homo sapiens_hsa040680.25073629
130mTOR signaling pathway_Homo sapiens_hsa041500.24099404
131Bladder cancer_Homo sapiens_hsa052190.24089070
132Inositol phosphate metabolism_Homo sapiens_hsa005620.23107646

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