RGS20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-serine metabolic process (GO:0006563)5.94103532
2response to pheromone (GO:0019236)5.21494438
3melanin biosynthetic process (GO:0042438)4.71770501
4central nervous system myelination (GO:0022010)4.70080634
5axon ensheathment in central nervous system (GO:0032291)4.70080634
6neuron cell-cell adhesion (GO:0007158)4.47563577
7presynaptic membrane assembly (GO:0097105)4.41374100
8secondary metabolite biosynthetic process (GO:0044550)4.32843580
9L-amino acid import (GO:0043092)4.29899124
10melanin metabolic process (GO:0006582)4.21401317
11presynaptic membrane organization (GO:0097090)4.07405302
12cerebral cortex radially oriented cell migration (GO:0021799)4.05718489
13postsynaptic membrane organization (GO:0001941)3.92633355
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.80309032
15vocalization behavior (GO:0071625)3.79784798
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.68637086
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.68578998
18plasma membrane fusion (GO:0045026)3.65925320
19lens fiber cell development (GO:0070307)3.63116451
20negative regulation of synaptic transmission, GABAergic (GO:0032229)3.58747583
21amino acid import (GO:0043090)3.56482786
22glutamate receptor signaling pathway (GO:0007215)3.54573537
23protein localization to synapse (GO:0035418)3.53519036
24chaperone-mediated protein transport (GO:0072321)3.52557138
25limb bud formation (GO:0060174)3.52105186
26serine family amino acid biosynthetic process (GO:0009070)3.44366481
27astrocyte differentiation (GO:0048708)3.44234657
28DNA damage response, detection of DNA damage (GO:0042769)3.42773629
29neuronal action potential propagation (GO:0019227)3.38095170
30L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.33527266
31G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.31001199
32water-soluble vitamin biosynthetic process (GO:0042364)3.26489163
33radial glial cell differentiation (GO:0060019)3.25929520
34cellular potassium ion homeostasis (GO:0030007)3.24991160
35neurotransmitter-gated ion channel clustering (GO:0072578)3.24192617
36tongue development (GO:0043586)3.22639333
37regulation of glutamate receptor signaling pathway (GO:1900449)3.22463140
38neuronal stem cell maintenance (GO:0097150)3.14638737
39negative regulation of neurotransmitter transport (GO:0051589)3.13203555
40retinal rod cell development (GO:0046548)3.11879397
41synaptic transmission, glutamatergic (GO:0035249)3.10135076
42dendritic spine morphogenesis (GO:0060997)3.09365071
43transmission of nerve impulse (GO:0019226)3.08641637
44auditory behavior (GO:0031223)3.08473559
45response to auditory stimulus (GO:0010996)3.08003434
46neuron-neuron synaptic transmission (GO:0007270)3.07468969
47neuron recognition (GO:0008038)3.07440123
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06515117
49long-chain fatty acid biosynthetic process (GO:0042759)3.04852885
50regulation of timing of cell differentiation (GO:0048505)3.04407480
51mitotic metaphase plate congression (GO:0007080)3.04343523
52protein heterotetramerization (GO:0051290)3.00850027
53positive regulation of synapse assembly (GO:0051965)3.00061467
54startle response (GO:0001964)2.99653053
55intraciliary transport (GO:0042073)2.96101823
56regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96033247
57proteasome assembly (GO:0043248)2.94942382
58response to redox state (GO:0051775)2.94875307
59photoreceptor cell differentiation (GO:0046530)2.92675714
60eye photoreceptor cell differentiation (GO:0001754)2.92675714
61C4-dicarboxylate transport (GO:0015740)2.92566816
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91841152
63substrate-independent telencephalic tangential migration (GO:0021826)2.90592922
64substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.90592922
65positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.89969202
66positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.89853493
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.87698764
68mechanosensory behavior (GO:0007638)2.86824982
69calcium-mediated signaling using intracellular calcium source (GO:0035584)2.86186811
70cell proliferation in forebrain (GO:0021846)2.83750456
71membrane repolarization (GO:0086009)2.83390451
72regulation of synaptic transmission, glutamatergic (GO:0051966)2.83189465
73gamma-aminobutyric acid signaling pathway (GO:0007214)2.82392251
74negative regulation of protein localization to cell surface (GO:2000009)2.81419172
75forebrain neuron differentiation (GO:0021879)2.81223942
76regulation of short-term neuronal synaptic plasticity (GO:0048172)2.80000076
77synaptic vesicle exocytosis (GO:0016079)2.77747484
78melanosome transport (GO:0032402)2.77624075
79retina layer formation (GO:0010842)2.76232713
80negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.75220262
81pattern specification involved in kidney development (GO:0061004)2.73785466
82negative regulation of glucose import (GO:0046325)2.73387407
83oligodendrocyte differentiation (GO:0048709)2.72308344
84long-term synaptic potentiation (GO:0060291)2.70284207
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.70098471
86regulation of rhodopsin mediated signaling pathway (GO:0022400)2.67375038
87negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.67091436
88metaphase plate congression (GO:0051310)2.66720136
89retinal ganglion cell axon guidance (GO:0031290)2.66240813
90negative regulation of astrocyte differentiation (GO:0048712)2.66232259
91long-term memory (GO:0007616)2.65942395
92axonal fasciculation (GO:0007413)2.65031502
93negative regulation of oligodendrocyte differentiation (GO:0048715)2.64999470
94regulation of excitatory postsynaptic membrane potential (GO:0060079)2.64104384
95positive regulation of action potential (GO:0045760)2.62999330
96maturation of SSU-rRNA (GO:0030490)2.62167768
97regulation of development, heterochronic (GO:0040034)2.61310907
98lateral sprouting from an epithelium (GO:0060601)2.61113470
99neurotransmitter uptake (GO:0001504)2.60790629
100behavioral response to cocaine (GO:0048148)2.60606402
101protein neddylation (GO:0045116)2.60540402
102adult walking behavior (GO:0007628)2.60537024
103locomotory exploration behavior (GO:0035641)2.60487635
104membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.60328977
105establishment of melanosome localization (GO:0032401)2.60110038
106neuron remodeling (GO:0016322)2.59192174
107regulation of respiratory system process (GO:0044065)2.59096362
108synapse assembly (GO:0007416)2.58837994
109rhodopsin mediated signaling pathway (GO:0016056)2.58464314
110nonmotile primary cilium assembly (GO:0035058)2.57815861
111regulation of synapse assembly (GO:0051963)2.57497678
112negative regulation of neurotransmitter secretion (GO:0046929)2.56831987
113central nervous system projection neuron axonogenesis (GO:0021952)2.56361264
114gamma-aminobutyric acid transport (GO:0015812)2.56055202
115regulation of synaptic vesicle exocytosis (GO:2000300)2.55576646
116positive regulation of membrane potential (GO:0045838)2.54518859
117regulation of postsynaptic membrane potential (GO:0060078)2.54327716
118hemidesmosome assembly (GO:0031581)2.53918499
119pigment granule transport (GO:0051904)2.53154462
120positive regulation of mitochondrial fission (GO:0090141)2.51476902
121positive regulation of synaptic transmission, GABAergic (GO:0032230)2.50719242
122positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.50593845
123L-methionine salvage (GO:0071267)2.49637062
124L-methionine biosynthetic process (GO:0071265)2.49637062
125amino acid salvage (GO:0043102)2.49637062
126cyclic nucleotide catabolic process (GO:0009214)2.49200289
127response to histamine (GO:0034776)2.49128691
128CENP-A containing nucleosome assembly (GO:0034080)2.49007126
129membrane hyperpolarization (GO:0060081)2.48913975
130protein K6-linked ubiquitination (GO:0085020)2.48505056
131regulation of respiratory gaseous exchange (GO:0043576)2.47202457
132melanosome localization (GO:0032400)2.47184887
133righting reflex (GO:0060013)2.46401011
134regulation of vesicle fusion (GO:0031338)2.46015965
135glutamate secretion (GO:0014047)2.45993260
136neuronal ion channel clustering (GO:0045161)2.45755224
137regulation of inositol phosphate biosynthetic process (GO:0010919)2.45323841
138ribosomal large subunit biogenesis (GO:0042273)2.45225007
139mechanoreceptor differentiation (GO:0042490)2.45050871
140positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.44039685
141hypothalamus development (GO:0021854)2.43917054
142myelination (GO:0042552)2.43201383
143melanosome organization (GO:0032438)2.42870666
144regulation of dendritic spine development (GO:0060998)2.42477692
145regulation of long-term neuronal synaptic plasticity (GO:0048169)2.42013552
146mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.42008878
147regulation of neurotransmitter secretion (GO:0046928)2.41897652
148photoreceptor cell maintenance (GO:0045494)2.41225160
149regulation of synaptic transmission, GABAergic (GO:0032228)2.41039460
150positive regulation of Notch signaling pathway (GO:0045747)2.40758517
151chromatin remodeling at centromere (GO:0031055)2.40592522
152regulation of neuronal synaptic plasticity (GO:0048168)2.40370982
153synaptic transmission, dopaminergic (GO:0001963)2.39745888
154establishment of pigment granule localization (GO:0051905)2.37465800
155regulation of glutamate secretion (GO:0014048)2.37075888
156positive regulation of dendritic spine development (GO:0060999)2.36574758
157positive regulation of neuroblast proliferation (GO:0002052)2.35626884
158spinal cord development (GO:0021510)2.35600098
159neuron fate determination (GO:0048664)2.35173051
160regulation of penile erection (GO:0060405)2.34362594
161positive regulation of receptor recycling (GO:0001921)2.34148225
162endosome to melanosome transport (GO:0035646)2.30024912
163endosome to pigment granule transport (GO:0043485)2.30024912
164pigment granule localization (GO:0051875)2.26869195
165negative regulation of glial cell differentiation (GO:0045686)2.26188367
166pigment granule organization (GO:0048753)2.25801104
167anterograde axon cargo transport (GO:0008089)2.25014312
168positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.23449294
169regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.23449294
170cerebral cortex cell migration (GO:0021795)2.21006808
171sodium ion export (GO:0071436)2.18919146
172lipopolysaccharide biosynthetic process (GO:0009103)2.18443296
173membrane assembly (GO:0071709)2.18125813
174forebrain neuron development (GO:0021884)2.17611089
175auditory receptor cell differentiation (GO:0042491)2.17323781
176regulation of astrocyte differentiation (GO:0048710)2.17297867
177hair cell differentiation (GO:0035315)2.16976283
178regulation of non-canonical Wnt signaling pathway (GO:2000050)2.16049851
179regulation of mitotic spindle organization (GO:0060236)2.14729428
180mitotic chromosome condensation (GO:0007076)2.13660472
181ATP synthesis coupled proton transport (GO:0015986)2.13654766
182energy coupled proton transport, down electrochemical gradient (GO:0015985)2.13654766
183deoxyribonucleotide biosynthetic process (GO:0009263)2.13632855
184astrocyte development (GO:0014002)2.13510863
185deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.13457026
186tRNA methylation (GO:0030488)2.12897908
187establishment of chromosome localization (GO:0051303)2.12724033
188anterograde synaptic vesicle transport (GO:0048490)2.12177282
189positive regulation of vascular permeability (GO:0043117)2.11957277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.69517810
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.51256044
3GBX2_23144817_ChIP-Seq_PC3_Human3.70011051
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.55990042
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.12241010
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.04505825
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95926430
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79950599
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.72465590
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70586849
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64081789
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.63340873
13* EED_16625203_ChIP-ChIP_MESCs_Mouse2.59864049
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54600458
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43222606
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43158693
17* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42376053
18* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42376053
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37434456
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33349577
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30936553
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30210794
23TRIM28_21343339_ChIP-Seq_HEK293_Human2.24325733
24ELK1_19687146_ChIP-ChIP_HELA_Human2.21750913
25CBX2_27304074_Chip-Seq_ESCs_Mouse2.20585303
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17461189
27AR_21572438_ChIP-Seq_LNCaP_Human2.11681434
28* EZH2_27294783_Chip-Seq_ESCs_Mouse2.08368697
29* RNF2_27304074_Chip-Seq_ESCs_Mouse2.07475978
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07372869
31TAF15_26573619_Chip-Seq_HEK293_Human2.05627931
32BMI1_23680149_ChIP-Seq_NPCS_Mouse2.05372905
33* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04766903
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.02649557
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02591014
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02166430
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.99301754
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93607073
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93230468
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.87360512
41VDR_22108803_ChIP-Seq_LS180_Human1.86000722
42ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.84820203
43* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84279729
44E2F7_22180533_ChIP-Seq_HELA_Human1.82399305
45AR_21909140_ChIP-Seq_LNCAP_Human1.82010600
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80399581
47* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.78769339
48P300_19829295_ChIP-Seq_ESCs_Human1.76165502
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.75010094
50REST_21632747_ChIP-Seq_MESCs_Mouse1.74767231
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73344731
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70141885
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67495968
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64871823
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64387382
56DROSHA_22980978_ChIP-Seq_HELA_Human1.62909110
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58676662
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.58505675
59TP53_16413492_ChIP-PET_HCT116_Human1.58354210
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57372055
61RNF2_27304074_Chip-Seq_NSC_Mouse1.57155138
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56245266
63DCP1A_22483619_ChIP-Seq_HELA_Human1.56101572
64SMAD4_21799915_ChIP-Seq_A2780_Human1.53971875
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.53874590
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51558102
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51486968
68IGF1R_20145208_ChIP-Seq_DFB_Human1.49095715
69* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49045743
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47498190
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.45760288
72E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45195256
73* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44091374
74* GABP_19822575_ChIP-Seq_HepG2_Human1.42428399
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42034697
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.41641135
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40600411
78* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40576990
79* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39767188
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39428549
81* NANOG_18555785_Chip-Seq_ESCs_Mouse1.38223296
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.38160542
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37798621
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36921560
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35434878
86* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35319734
87CJUN_26792858_Chip-Seq_BT549_Human1.34676155
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34649040
89FUS_26573619_Chip-Seq_HEK293_Human1.33818235
90* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33325641
91ER_23166858_ChIP-Seq_MCF-7_Human1.32253976
92NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31023610
93* FLI1_27457419_Chip-Seq_LIVER_Mouse1.30914276
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30256043
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29975991
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29944946
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28838234
98XRN2_22483619_ChIP-Seq_HELA_Human1.28759952
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28306334
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27208651
101* E2F1_18555785_Chip-Seq_ESCs_Mouse1.26961495
102TP53_18474530_ChIP-ChIP_U2OS_Human1.26638346
103TTF2_22483619_ChIP-Seq_HELA_Human1.24220326
104CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.23752643
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22697713
106AR_25329375_ChIP-Seq_VCAP_Human1.22619973
107* P53_22387025_ChIP-Seq_ESCs_Mouse1.22455273
108* SOX9_26525672_Chip-Seq_HEART_Mouse1.22219836
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21366153
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21366153
111* CMYC_18555785_Chip-Seq_ESCs_Mouse1.21323889
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20630218
113* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19827663
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19090788
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17727136
116* NFE2_27457419_Chip-Seq_LIVER_Mouse1.17188757
117HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17137729
118* REST_18959480_ChIP-ChIP_MESCs_Mouse1.16950561
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16904707
120TP53_22127205_ChIP-Seq_IMR90_Human1.16306827
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15665256
122EWS_26573619_Chip-Seq_HEK293_Human1.15349798
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15310052
124* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15301186
125* RING1B_27294783_Chip-Seq_ESCs_Mouse1.15299485
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15299223
127MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15292844
128MYC_18940864_ChIP-ChIP_HL60_Human1.15289022
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14360026
130* RUNX2_22187159_ChIP-Seq_PCA_Human1.14152379
131* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.13147395
132STAT3_23295773_ChIP-Seq_U87_Human1.13058855
133SRF_21415370_ChIP-Seq_HL-1_Mouse1.12788298
134NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12663652
135* P300_18555785_Chip-Seq_ESCs_Mouse1.12162589
136HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11722798
137* STAT3_18555785_Chip-Seq_ESCs_Mouse1.11663582
138E2F1_21310950_ChIP-Seq_MCF-7_Human1.10756534
139* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10581499
140MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10510063
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09920400
142POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09734430
143* EZH2_27294783_Chip-Seq_NPCs_Mouse1.08400830
144ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08059158
145CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07592774
146FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07557816
147* RING1B_27294783_Chip-Seq_NPCs_Mouse1.06884650
148RARB_27405468_Chip-Seq_BRAIN_Mouse1.06428161
149* NMYC_18555785_Chip-Seq_ESCs_Mouse1.06256259
150* SOX2_18555785_Chip-Seq_ESCs_Mouse1.05863494
151P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05783879
152CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05635204
153TCF4_23295773_ChIP-Seq_U87_Human1.05382261
154TAL1_26923725_Chip-Seq_HPCs_Mouse1.05321642
155ARNT_22903824_ChIP-Seq_MCF-7_Human1.05253972
156* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04913942
157* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04533498
158* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04492168
159AHR_22903824_ChIP-Seq_MCF-7_Human1.02318036
160MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02139710
161SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01657264
162PRDM14_20953172_ChIP-Seq_ESCs_Human1.01136208
163SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00666739
164VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00389269
165MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00123744
166SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99870139
167EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99845779
168SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99800309
169POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97243580
170PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97219839
171ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96416073
172SOX17_20123909_ChIP-Seq_XEN_Mouse0.94811430
173POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94230244
174REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93348371
175EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92360973
176UBF1/2_26484160_Chip-Seq_HMECs_Human0.92011116
177SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91897142
178SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91897142
179MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91890890
180SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89826553
181* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87039814
182* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85743965
183RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85235530
184BRD4_25478319_ChIP-Seq_HGPS_Human0.84885954
185* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84402344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.17756671
2MP0004859_abnormal_synaptic_plasticity3.12719981
3MP0001486_abnormal_startle_reflex2.93389059
4MP0003136_yellow_coat_color2.87900969
5MP0005248_abnormal_Harderian_gland2.87278213
6MP0001188_hyperpigmentation2.83852440
7MP0005257_abnormal_intraocular_pressure2.81519207
8MP0002095_abnormal_skin_pigmentation2.77652487
9MP0003635_abnormal_synaptic_transmissio2.59503588
10MP0005423_abnormal_somatic_nervous2.59326073
11MP0009745_abnormal_behavioral_response2.55980085
12MP0006292_abnormal_olfactory_placode2.54598255
13MP0000566_synostosis2.52041890
14MP0009046_muscle_twitch2.51237574
15MP0005408_hypopigmentation2.48990205
16MP0005646_abnormal_pituitary_gland2.45770849
17MP0002877_abnormal_melanocyte_morpholog2.39284988
18MP0002064_seizures2.35663720
19MP0004270_analgesia2.25439077
20MP0002572_abnormal_emotion/affect_behav2.25125605
21MP0005551_abnormal_eye_electrophysiolog2.20819473
22MP0002063_abnormal_learning/memory/cond2.20550002
23MP0001968_abnormal_touch/_nociception2.20484642
24MP0002272_abnormal_nervous_system2.20161205
25MP0005645_abnormal_hypothalamus_physiol2.19219411
26MP0005409_darkened_coat_color2.16392258
27MP0010030_abnormal_orbit_morphology2.14500606
28MP0002102_abnormal_ear_morphology2.09391115
29MP0004742_abnormal_vestibular_system2.08667960
30MP0000778_abnormal_nervous_system1.96843453
31MP0009053_abnormal_anal_canal1.96555123
32MP0002938_white_spotting1.94275676
33MP0005174_abnormal_tail_pigmentation1.85816691
34MP0002734_abnormal_mechanical_nocicepti1.85145667
35MP0001984_abnormal_olfaction1.79956746
36MP0002638_abnormal_pupillary_reflex1.77830535
37MP0002067_abnormal_sensory_capabilities1.75764622
38MP0005171_absent_coat_pigmentation1.73454319
39MP0002736_abnormal_nociception_after1.70366156
40MP0001440_abnormal_grooming_behavior1.68757251
41MP0004142_abnormal_muscle_tone1.67708988
42MP0002557_abnormal_social/conspecific_i1.67000531
43MP0002735_abnormal_chemical_nociception1.66884522
44MP0001529_abnormal_vocalization1.66701957
45MP0006276_abnormal_autonomic_nervous1.64768844
46MP0001485_abnormal_pinna_reflex1.64284265
47MP0001501_abnormal_sleep_pattern1.63411479
48MP0004381_abnormal_hair_follicle1.61772762
49MP0002653_abnormal_ependyma_morphology1.58786102
50MP0003755_abnormal_palate_morphology1.58493851
51MP0001905_abnormal_dopamine_level1.57544953
52MP0002822_catalepsy1.56494423
53MP0006072_abnormal_retinal_apoptosis1.49184943
54MP0005197_abnormal_uvea_morphology1.46987767
55MP0001970_abnormal_pain_threshold1.46844045
56MP0005623_abnormal_meninges_morphology1.46018366
57MP0001502_abnormal_circadian_rhythm1.45175759
58MP0000026_abnormal_inner_ear1.45104998
59MP0002184_abnormal_innervation1.44873112
60MP0000920_abnormal_myelination1.44514798
61MP0005253_abnormal_eye_physiology1.44177565
62MP0004885_abnormal_endolymph1.43875121
63MP0000371_diluted_coat_color1.43546339
64MP0000762_abnormal_tongue_morphology1.42555123
65MP0002733_abnormal_thermal_nociception1.41741642
66MP0001963_abnormal_hearing_physiology1.39083979
67MP0005075_abnormal_melanosome_morpholog1.38928690
68MP0008932_abnormal_embryonic_tissue1.38155041
69MP0000631_abnormal_neuroendocrine_gland1.37853843
70MP0003186_abnormal_redox_activity1.37165441
71MP0008569_lethality_at_weaning1.35588169
72MP0001293_anophthalmia1.35207546
73MP0003938_abnormal_ear_development1.34485996
74MP0002882_abnormal_neuron_morphology1.34224438
75MP0001986_abnormal_taste_sensitivity1.32261142
76MP0001324_abnormal_eye_pigmentation1.31962148
77MP0003011_delayed_dark_adaptation1.27279905
78MP0002752_abnormal_somatic_nervous1.26214688
79MP0003690_abnormal_glial_cell1.20135348
80MP0006054_spinal_hemorrhage1.18128915
81MP0001346_abnormal_lacrimal_gland1.16692183
82MP0010368_abnormal_lymphatic_system1.15838735
83MP0001299_abnormal_eye_distance/1.15666365
84MP0002234_abnormal_pharynx_morphology1.14828815
85MP0004272_abnormal_basement_membrane1.12071208
86MP0005386_behavior/neurological_phenoty1.11802843
87MP0004924_abnormal_behavior1.11802843
88MP0000358_abnormal_cell_content/1.10608035
89MP0000049_abnormal_middle_ear1.10409649
90MP0005391_vision/eye_phenotype1.07816710
91MP0002092_abnormal_eye_morphology1.07368568
92MP0003787_abnormal_imprinting1.07311524
93MP0002075_abnormal_coat/hair_pigmentati1.06319079
94MP0005499_abnormal_olfactory_system1.06316863
95MP0005394_taste/olfaction_phenotype1.06316863
96MP0003634_abnormal_glial_cell1.04716508
97MP0002229_neurodegeneration1.04622260
98MP0001186_pigmentation_phenotype1.03504625
99MP0000955_abnormal_spinal_cord1.03360490
100MP0002066_abnormal_motor_capabilities/c1.03113923
101MP0002249_abnormal_larynx_morphology1.02501473
102MP0002697_abnormal_eye_size1.02048512
103MP0002177_abnormal_outer_ear1.00701797
104MP0005379_endocrine/exocrine_gland_phen1.00305017
105MP0005195_abnormal_posterior_eye1.00116536
106MP0008789_abnormal_olfactory_epithelium0.98846784
107MP0001286_abnormal_eye_development0.97244996
108MP0002233_abnormal_nose_morphology0.95017075
109MP0003950_abnormal_plasma_membrane0.93700882
110MP0003385_abnormal_body_wall0.93465361
111MP0002277_abnormal_respiratory_mucosa0.90780114
112MP0009379_abnormal_foot_pigmentation0.90729396
113MP0009697_abnormal_copulation0.90378847
114MP0002152_abnormal_brain_morphology0.89444110
115MP0005377_hearing/vestibular/ear_phenot0.88579922
116MP0003878_abnormal_ear_physiology0.88579922
117MP0002876_abnormal_thyroid_physiology0.88353738
118MP0000343_altered_response_to0.88326120
119MP0004858_abnormal_nervous_system0.86825466
120MP0003879_abnormal_hair_cell0.85666035
121MP0003633_abnormal_nervous_system0.85485333
122MP0009250_abnormal_appendicular_skeleto0.84955690
123MP0002090_abnormal_vision0.84600441
124MP0005193_abnormal_anterior_eye0.84521671
125MP0009780_abnormal_chondrocyte_physiolo0.83175711
126MP0001340_abnormal_eyelid_morphology0.81879301
127MP0005187_abnormal_penis_morphology0.80257392
128MP0000537_abnormal_urethra_morphology0.78241115
129MP0000579_abnormal_nail_morphology0.77584619
130MP0003631_nervous_system_phenotype0.77187528
131MP0003942_abnormal_urinary_system0.75072869
132MP0000015_abnormal_ear_pigmentation0.74862726
133MP0001879_abnormal_lymphatic_vessel0.74780147
134MP0004811_abnormal_neuron_physiology0.74760326
135MP0000613_abnormal_salivary_gland0.74666437
136MP0001664_abnormal_digestion0.74551053
137MP0001849_ear_inflammation0.72848741
138MP0000647_abnormal_sebaceous_gland0.71977790
139MP0003861_abnormal_nervous_system0.71752987
140MP0002163_abnormal_gland_morphology0.71171775
141MP0000569_abnormal_digit_pigmentation0.71166620
142MP0000428_abnormal_craniofacial_morphol0.69569587
143MP0000372_irregular_coat_pigmentation0.67417780
144MP0003705_abnormal_hypodermis_morpholog0.67327710
145MP0001177_atelectasis0.67116588
146MP0010386_abnormal_urinary_bladder0.67028707
147MP0008004_abnormal_stomach_pH0.64223253
148MP0000383_abnormal_hair_follicle0.62288253
149MP0002069_abnormal_eating/drinking_beha0.61278041

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.16487798
2Parakeratosis (HP:0001036)3.79443056
3Absent/shortened dynein arms (HP:0200106)3.70034808
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.70034808
5Median cleft lip (HP:0000161)3.63623629
6Myokymia (HP:0002411)3.55746879
7Coronal craniosynostosis (HP:0004440)3.46094825
8Epileptic encephalopathy (HP:0200134)3.45211905
9Aplasia involving bones of the upper limbs (HP:0009823)3.34846659
10Aplasia of the phalanges of the hand (HP:0009802)3.34846659
11Aplasia involving bones of the extremities (HP:0009825)3.34846659
12Febrile seizures (HP:0002373)3.34320425
13Congenital stationary night blindness (HP:0007642)3.25253535
14Progressive cerebellar ataxia (HP:0002073)3.18582623
15Adrenal hypoplasia (HP:0000835)3.18105179
16Poor head control (HP:0002421)3.15624797
17Hyperventilation (HP:0002883)3.15269690
18Septo-optic dysplasia (HP:0100842)3.15179923
19Abnormal ciliary motility (HP:0012262)3.02080438
20Focal seizures (HP:0007359)3.01597298
21Oligodactyly (hands) (HP:0001180)2.93449063
22Reticulocytopenia (HP:0001896)2.90677661
23Facial cleft (HP:0002006)2.85822643
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.82212386
25Oligodactyly (HP:0012165)2.78846104
26Fragile nails (HP:0001808)2.70976420
27Pancreatic fibrosis (HP:0100732)2.61458219
28Abnormal respiratory motile cilium physiology (HP:0012261)2.60663049
29Medial flaring of the eyebrow (HP:0010747)2.59371509
30Decreased central vision (HP:0007663)2.58495005
31Abnormal respiratory motile cilium morphology (HP:0005938)2.58331911
32Abnormal respiratory epithelium morphology (HP:0012253)2.58331911
33Gait imbalance (HP:0002141)2.57735557
34Broad-based gait (HP:0002136)2.57583202
35Absent septum pellucidum (HP:0001331)2.56089740
36Abnormality of the axillary hair (HP:0100134)2.48780771
37Abnormality of secondary sexual hair (HP:0009888)2.48780771
38Aplasia/Hypoplasia of the fovea (HP:0008060)2.47721013
39Hypoplasia of the fovea (HP:0007750)2.47721013
40Nephrogenic diabetes insipidus (HP:0009806)2.45435235
41Hypoplastic pelvis (HP:0008839)2.43892818
42Congenital hepatic fibrosis (HP:0002612)2.40077785
43Atonic seizures (HP:0010819)2.40007218
44Split foot (HP:0001839)2.39986183
45Congenital primary aphakia (HP:0007707)2.38327033
46Abnormality of the fovea (HP:0000493)2.37429564
47Nuclear cataract (HP:0100018)2.34828618
48Megalencephaly (HP:0001355)2.34365064
49Heterochromia iridis (HP:0001100)2.33207021
50Retinal dysplasia (HP:0007973)2.32614733
51Preaxial hand polydactyly (HP:0001177)2.30940549
52Mixed hearing impairment (HP:0000410)2.30561533
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.28804807
54Broad foot (HP:0001769)2.28802214
55Abnormality of midbrain morphology (HP:0002418)2.28766405
56Molar tooth sign on MRI (HP:0002419)2.28766405
57Abnormality of the septum pellucidum (HP:0007375)2.27731397
58Postaxial foot polydactyly (HP:0001830)2.27675237
59Postaxial hand polydactyly (HP:0001162)2.26886706
60Optic nerve hypoplasia (HP:0000609)2.26636505
61Thickened helices (HP:0000391)2.26454385
62Abnormal auditory evoked potentials (HP:0006958)2.23713197
63Ocular albinism (HP:0001107)2.22278591
64Blue irides (HP:0000635)2.22191929
65Fibular hypoplasia (HP:0003038)2.20831356
66Adactyly (HP:0009776)2.19697212
67Limb dystonia (HP:0002451)2.18674734
68Abnormality of glycolipid metabolism (HP:0010969)2.18413898
69Abnormality of liposaccharide metabolism (HP:0010968)2.18413898
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.18413898
71Conical tooth (HP:0000698)2.18305517
72Iris hypopigmentation (HP:0007730)2.18210993
73Acute necrotizing encephalopathy (HP:0006965)2.16065604
74Aplasia/Hypoplasia of the fibula (HP:0006492)2.15484265
75Vaginal atresia (HP:0000148)2.14424787
76Rib fusion (HP:0000902)2.14344175
77Abnormality of incisor morphology (HP:0011063)2.14301485
78Degeneration of the lateral corticospinal tracts (HP:0002314)2.14192892
79Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14192892
80Generalized tonic-clonic seizures (HP:0002069)2.13631268
81Dialeptic seizures (HP:0011146)2.13175105
82Genital tract atresia (HP:0001827)2.12748905
83Dysdiadochokinesis (HP:0002075)2.12519722
84Increased corneal curvature (HP:0100692)2.12444571
85Keratoconus (HP:0000563)2.12444571
86Mesomelia (HP:0003027)2.10480668
87Onycholysis (HP:0001806)2.09342589
88Humeroradial synostosis (HP:0003041)2.08737151
89Synostosis involving the elbow (HP:0003938)2.08737151
90Hemiparesis (HP:0001269)2.05344755
91True hermaphroditism (HP:0010459)2.05256823
92Hemivertebrae (HP:0002937)2.04868983
93Aplasia/Hypoplasia of the lens (HP:0008063)2.04733650
94Absence seizures (HP:0002121)2.04112433
95Pterygium (HP:0001059)2.02495182
96Increased serum pyruvate (HP:0003542)2.02394084
97White forelock (HP:0002211)2.00829002
98Abnormal mitochondria in muscle tissue (HP:0008316)2.00810538
99Attenuation of retinal blood vessels (HP:0007843)2.00408546
100Alacrima (HP:0000522)1.99713509
101Facial hemangioma (HP:0000329)1.98936409
102Clumsiness (HP:0002312)1.97623515
103Nasolacrimal duct obstruction (HP:0000579)1.97418392
104Peripheral hypomyelination (HP:0007182)1.97357265
105Short foot (HP:0001773)1.96633313
106Short nail (HP:0001799)1.95116157
107Neurofibrillary tangles (HP:0002185)1.94950323
108Cortical dysplasia (HP:0002539)1.94870068
109Patent foramen ovale (HP:0001655)1.94474552
110Aplasia/Hypoplasia of the macula (HP:0008059)1.93616385
111Gaze-evoked nystagmus (HP:0000640)1.91357851
112Diplopia (HP:0000651)1.91066229
113Abnormality of binocular vision (HP:0011514)1.91066229
114Aplasia cutis congenita (HP:0001057)1.90837877
115Abnormal hair whorl (HP:0010721)1.90701566
116Patchy hypopigmentation of hair (HP:0011365)1.89973370
117Chronic hepatic failure (HP:0100626)1.89451347
118Dyschromatopsia (HP:0007641)1.88336737
119Cupped ear (HP:0000378)1.87254385
120Action tremor (HP:0002345)1.85720429
121Esophageal atresia (HP:0002032)1.85438532
122Pancreatic cysts (HP:0001737)1.85281424
123Premature graying of hair (HP:0002216)1.85271843
124Decreased lacrimation (HP:0000633)1.84528243
125Hypoplastic left heart (HP:0004383)1.84466133
126Absent speech (HP:0001344)1.83809896
127Nephronophthisis (HP:0000090)1.83579666
128Duplication of thumb phalanx (HP:0009942)1.83336830
129Morphological abnormality of the middle ear (HP:0008609)1.82130053
130Tubulointerstitial nephritis (HP:0001970)1.81961987
131Gastrointestinal atresia (HP:0002589)1.81273566
132Sex reversal (HP:0012245)1.81207609
133Abnormal sex determination (HP:0012244)1.81207609
134Milia (HP:0001056)1.80864392
135Macrocytic anemia (HP:0001972)1.80415526
136Aplasia/Hypoplasia affecting the retina (HP:0008061)1.79985856
137Abnormality of the dental pulp (HP:0006479)1.79607423
138Abnormality of macular pigmentation (HP:0008002)1.79511996
139Albinism (HP:0001022)1.78981241
140Abnormality of glycolysis (HP:0004366)1.77500227
141Congenital sensorineural hearing impairment (HP:0008527)1.76810962
142Corneal dystrophy (HP:0001131)1.76724442
143Abnormality of the lacrimal duct (HP:0011481)1.75816505
144Anencephaly (HP:0002323)1.75521154
145Specific learning disability (HP:0001328)1.75408464
146Postnatal microcephaly (HP:0005484)1.75293935
147Hand muscle atrophy (HP:0009130)1.75141383
148Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75072330
149Astigmatism (HP:0000483)1.74973242
150Abnormality of the diencephalon (HP:0010662)1.74845137
151Abnormality of subcutaneous fat tissue (HP:0001001)1.74412560
152Abnormality of molar morphology (HP:0011070)1.74022496
153Abnormality of molar (HP:0011077)1.74022496
154Down-sloping shoulders (HP:0200021)1.73992812
155Long nose (HP:0003189)1.73778237
156Hypopigmentation of the fundus (HP:0007894)1.73610769
157Wrist flexion contracture (HP:0001239)1.73290165
158Polyphagia (HP:0002591)1.73284653
159Abnormality of nail color (HP:0100643)1.72648291
160Aganglionic megacolon (HP:0002251)1.72587637
161Posterior subcapsular cataract (HP:0007787)1.72006899
162Abnormal rod and cone electroretinograms (HP:0008323)1.71199474
163Progressive macrocephaly (HP:0004481)1.71005193
164Dysmetria (HP:0001310)1.70203114
165Acute encephalopathy (HP:0006846)1.69701442
166Excessive salivation (HP:0003781)1.69465549
167Drooling (HP:0002307)1.69465549
168Abnormality of the nasolacrimal system (HP:0000614)1.69430914
169Large for gestational age (HP:0001520)1.69352101
170Optic disc pallor (HP:0000543)1.69188971
171Widely spaced teeth (HP:0000687)1.68262279
172Cystic liver disease (HP:0006706)1.68204896
173Taurodontia (HP:0000679)1.67621444
174Decreased testicular size (HP:0008734)1.66906335
175Absent eyelashes (HP:0000561)1.66862026
176Intestinal atresia (HP:0011100)1.66515599
177Stenosis of the external auditory canal (HP:0000402)1.63756997
178Entropion (HP:0000621)1.62916676
179Cortical visual impairment (HP:0100704)1.61343629
180Sclerocornea (HP:0000647)1.59438855
181Absent hair (HP:0002298)1.58625752
182Aplasia/Hypoplasia of the tongue (HP:0010295)1.58116551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.19583725
2EPHA43.98160348
3TNIK3.61146037
4MOS2.77538793
5NEK12.75018626
6PRPF4B2.60339980
7NTRK32.60051544
8FER2.54362799
9CDC72.21144883
10NTRK22.21090660
11TRIM282.19895124
12MAP2K72.18895674
13WEE12.01741552
14BUB11.97245343
15MAPK131.92978950
16PIM21.90124693
17MUSK1.85221685
18MARK11.80606428
19OXSR11.76957030
20LIMK11.67746224
21STK391.64043990
22INSRR1.62710032
23MKNK21.55185234
24MST1R1.53361832
25GRK11.52746450
26PKN11.47158437
27NEK61.46977902
28ARAF1.44659809
29CDK191.44307095
30BMPR1B1.36715709
31BMPR21.36416280
32PLK31.33633575
33ERBB41.32658248
34MET1.31906202
35ADRBK21.31521972
36SGK2231.31089509
37SGK4941.31089509
38KSR11.30242129
39CDK31.27847410
40CSNK1G31.26754426
41MAP3K41.25033227
42SIK31.22713033
43SIK21.20784480
44IRAK21.18599528
45NEK91.17627034
46LATS21.15912010
47ERBB31.14899670
48FGR1.13242719
49EPHA21.12274078
50PAK41.11407180
51NME21.10624038
52FES1.10545225
53PHKG21.10482046
54PHKG11.10482046
55MAPKAPK51.09053061
56BCR1.08060291
57DAPK21.07614036
58ABL21.06441867
59RIPK41.06020774
60PLK21.05802507
61GRK71.05140374
62EIF2AK31.04565959
63PNCK1.04548524
64PAK61.03896087
65PRKCE1.03642894
66CAMK2A1.02303098
67SGK21.00850095
68CDK51.00605001
69CSNK1G11.00236704
70CCNB11.00183994
71PINK10.98457776
72UHMK10.93496399
73PLK10.92818140
74PTK20.92704630
75CAMK2B0.92645406
76STK160.92370054
77YES10.91637295
78BLK0.89864109
79EIF2AK10.88610443
80PBK0.86497361
81BRSK10.85941311
82TESK10.83999796
83DAPK30.82967718
84AKT30.81235582
85IRAK10.80553441
86GRK50.80537389
87EPHB20.80317606
88MAP3K130.79893529
89MAPK70.79489805
90DYRK1A0.79173740
91MAP3K120.78997554
92AURKB0.78025782
93DDR20.77512458
94PRKCG0.76977562
95MKNK10.73997940
96BRAF0.73002774
97DYRK20.72687517
98MINK10.72170849
99ADRBK10.71134121
100MAPK150.70317234
101NUAK10.70146793
102FGFR20.69331050
103CAMK2D0.69236822
104MAP3K90.69158956
105AURKA0.68588320
106WNK10.67937617
107CLK10.67884469
108MARK20.67109282
109VRK10.64376768
110AKT20.64350539
111TGFBR20.64214010
112SGK10.63698466
113TNK20.63406845
114ROCK10.62591383
115CAMK10.62509637
116MAPKAPK30.62440850
117IRAK30.60420598
118PRKG10.60062325
119MST40.59967369
120ROCK20.57173125
121TGFBR10.55290438
122PRKCQ0.54601920
123PAK20.53661641
124WNK30.53108268
125MAP2K40.51693617
126PRKD20.51583555
127NTRK10.49782628
128PRKACA0.48812068
129ILK0.48741779
130CDK180.47760566
131MAP3K140.47438310
132STK110.46979903
133CAMK2G0.46348340
134MAP4K20.45883624
135CDK150.45612956
136CSNK1G20.45411024
137PAK10.45159786
138CDK11A0.45062546
139MAPK120.44658932
140VRK20.44586519
141EIF2AK20.44093857
142CDK140.43946404
143TAOK20.43030351
144TXK0.42818412
145FLT30.41812595
146WNK40.41805151
147DMPK0.41313044
148LMTK20.40609850
149PIK3CA0.40016619
150CSNK1A1L0.39850796
151PRKD30.38900394
152CSNK1A10.38645002
153MYLK0.36834223
154LATS10.36781377

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.79933157
2Nicotine addiction_Homo sapiens_hsa050333.62518941
3Proteasome_Homo sapiens_hsa030502.73587296
4Glutamatergic synapse_Homo sapiens_hsa047242.64139233
5Morphine addiction_Homo sapiens_hsa050322.55003693
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52796612
7GABAergic synapse_Homo sapiens_hsa047272.47231757
8Nucleotide excision repair_Homo sapiens_hsa034202.44940499
9Ribosome_Homo sapiens_hsa030102.43697020
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.33957672
11Olfactory transduction_Homo sapiens_hsa047402.23654049
12Serotonergic synapse_Homo sapiens_hsa047262.23119988
13Mismatch repair_Homo sapiens_hsa034302.18409895
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.15690942
15Circadian entrainment_Homo sapiens_hsa047132.13823006
16Taste transduction_Homo sapiens_hsa047421.97257680
17Synaptic vesicle cycle_Homo sapiens_hsa047211.92400040
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.91503127
19Sulfur relay system_Homo sapiens_hsa041221.80593695
20Salivary secretion_Homo sapiens_hsa049701.78558508
21Folate biosynthesis_Homo sapiens_hsa007901.77697562
22Vitamin B6 metabolism_Homo sapiens_hsa007501.76557916
23Axon guidance_Homo sapiens_hsa043601.75500009
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74270651
25p53 signaling pathway_Homo sapiens_hsa041151.72663011
26Homologous recombination_Homo sapiens_hsa034401.70218753
27DNA replication_Homo sapiens_hsa030301.66338327
28Hippo signaling pathway_Homo sapiens_hsa043901.62796365
29Amphetamine addiction_Homo sapiens_hsa050311.61614202
30Protein export_Homo sapiens_hsa030601.59301928
31Cocaine addiction_Homo sapiens_hsa050301.59000728
32Fanconi anemia pathway_Homo sapiens_hsa034601.58471409
33Dopaminergic synapse_Homo sapiens_hsa047281.54264793
34Cholinergic synapse_Homo sapiens_hsa047251.53620874
35Calcium signaling pathway_Homo sapiens_hsa040201.53533070
36Long-term depression_Homo sapiens_hsa047301.53386152
37Collecting duct acid secretion_Homo sapiens_hsa049661.52962062
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.42915717
39Ether lipid metabolism_Homo sapiens_hsa005651.38776425
40Renin secretion_Homo sapiens_hsa049241.38129328
41Gastric acid secretion_Homo sapiens_hsa049711.36992725
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36062708
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35929124
44Biosynthesis of amino acids_Homo sapiens_hsa012301.35136610
45Long-term potentiation_Homo sapiens_hsa047201.35030869
46Insulin secretion_Homo sapiens_hsa049111.34935947
47Pyrimidine metabolism_Homo sapiens_hsa002401.34260763
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33541854
49Glutathione metabolism_Homo sapiens_hsa004801.32230712
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31546798
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29119494
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27229097
53Sphingolipid metabolism_Homo sapiens_hsa006001.25987650
54Nitrogen metabolism_Homo sapiens_hsa009101.24290093
55Oxidative phosphorylation_Homo sapiens_hsa001901.24029876
56Oxytocin signaling pathway_Homo sapiens_hsa049211.18392078
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11842976
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11797534
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11002591
60Fatty acid elongation_Homo sapiens_hsa000621.10550902
61Cell cycle_Homo sapiens_hsa041101.06866985
62cAMP signaling pathway_Homo sapiens_hsa040241.05903334
63Base excision repair_Homo sapiens_hsa034101.05005774
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03924638
65Basal transcription factors_Homo sapiens_hsa030220.99836428
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98908824
67Fatty acid biosynthesis_Homo sapiens_hsa000610.97493416
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96867813
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95133620
70Ras signaling pathway_Homo sapiens_hsa040140.94167827
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92860721
72RNA polymerase_Homo sapiens_hsa030200.92447956
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92221628
74African trypanosomiasis_Homo sapiens_hsa051430.91758984
75Melanogenesis_Homo sapiens_hsa049160.91343570
76Rheumatoid arthritis_Homo sapiens_hsa053230.89673655
77Alzheimers disease_Homo sapiens_hsa050100.88618720
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87444496
79Cardiac muscle contraction_Homo sapiens_hsa042600.87124040
80Steroid biosynthesis_Homo sapiens_hsa001000.86098480
81Gap junction_Homo sapiens_hsa045400.86079987
82ErbB signaling pathway_Homo sapiens_hsa040120.85753025
83Carbon metabolism_Homo sapiens_hsa012000.84866936
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.83365951
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83122493
86Wnt signaling pathway_Homo sapiens_hsa043100.83044721
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82952518
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82370800
89Ovarian steroidogenesis_Homo sapiens_hsa049130.80966875
90GnRH signaling pathway_Homo sapiens_hsa049120.80140389
91Non-homologous end-joining_Homo sapiens_hsa034500.78142494
92Adherens junction_Homo sapiens_hsa045200.77716959
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77521160
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76728654
95Oocyte meiosis_Homo sapiens_hsa041140.75797552
96MicroRNAs in cancer_Homo sapiens_hsa052060.75220198
97Circadian rhythm_Homo sapiens_hsa047100.75049039
98Autoimmune thyroid disease_Homo sapiens_hsa053200.73547198
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73113826
100Sulfur metabolism_Homo sapiens_hsa009200.72574129
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72497435
102Dorso-ventral axis formation_Homo sapiens_hsa043200.72104140
103Pancreatic secretion_Homo sapiens_hsa049720.71970674
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71173698
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70768779
106Propanoate metabolism_Homo sapiens_hsa006400.70726777
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.70433357
108N-Glycan biosynthesis_Homo sapiens_hsa005100.69164040
109Bladder cancer_Homo sapiens_hsa052190.69095233
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68752846
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.66713250
112Parkinsons disease_Homo sapiens_hsa050120.66158638
113Melanoma_Homo sapiens_hsa052180.64922018
114MAPK signaling pathway_Homo sapiens_hsa040100.63238874
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63088598
116Vibrio cholerae infection_Homo sapiens_hsa051100.62902497
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62509461
118Arachidonic acid metabolism_Homo sapiens_hsa005900.62102903
119Graft-versus-host disease_Homo sapiens_hsa053320.61862087
120Fructose and mannose metabolism_Homo sapiens_hsa000510.60777041
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60500675
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59397285
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59180646
124Rap1 signaling pathway_Homo sapiens_hsa040150.58265871
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57970197
126Peroxisome_Homo sapiens_hsa041460.57908007
127Choline metabolism in cancer_Homo sapiens_hsa052310.57227074
128RNA degradation_Homo sapiens_hsa030180.57203594
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56802044
130Pyruvate metabolism_Homo sapiens_hsa006200.56604002
131Basal cell carcinoma_Homo sapiens_hsa052170.55955916
132Hedgehog signaling pathway_Homo sapiens_hsa043400.54945707
133Linoleic acid metabolism_Homo sapiens_hsa005910.54486991
134Mineral absorption_Homo sapiens_hsa049780.54365705
135Pentose phosphate pathway_Homo sapiens_hsa000300.54157080
136One carbon pool by folate_Homo sapiens_hsa006700.53519821
137Metabolic pathways_Homo sapiens_hsa011000.53314292
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52780460
139Notch signaling pathway_Homo sapiens_hsa043300.52484438
140RNA transport_Homo sapiens_hsa030130.51666505
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49431851
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.48824986
143Galactose metabolism_Homo sapiens_hsa000520.48756452
144Asthma_Homo sapiens_hsa053100.48498046
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48195460
146Alcoholism_Homo sapiens_hsa050340.47485263
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47244612
148Type I diabetes mellitus_Homo sapiens_hsa049400.46005493
149ECM-receptor interaction_Homo sapiens_hsa045120.43756394
150Dilated cardiomyopathy_Homo sapiens_hsa054140.43125849
151Huntingtons disease_Homo sapiens_hsa050160.43113155
152Tyrosine metabolism_Homo sapiens_hsa003500.42524023
153Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41870728
154Primary bile acid biosynthesis_Homo sapiens_hsa001200.40840320
155Chemokine signaling pathway_Homo sapiens_hsa040620.40812521
156Fatty acid metabolism_Homo sapiens_hsa012120.40359968
157Arginine and proline metabolism_Homo sapiens_hsa003300.39569826
158Phagosome_Homo sapiens_hsa041450.38865299
159Thyroid hormone synthesis_Homo sapiens_hsa049180.33798342
160Allograft rejection_Homo sapiens_hsa053300.33497239
161Purine metabolism_Homo sapiens_hsa002300.33316232
162Renal cell carcinoma_Homo sapiens_hsa052110.32864239
163Estrogen signaling pathway_Homo sapiens_hsa049150.32393740
164Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29999508

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