RGS21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.33871059
2positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.33871059
3motile cilium assembly (GO:0044458)4.22765757
4regulation of activation of Janus kinase activity (GO:0010533)4.03716644
5atrial cardiac muscle cell action potential (GO:0086014)3.82112924
6positive regulation of cellular amide metabolic process (GO:0034250)3.78865416
7regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.76557106
8kidney morphogenesis (GO:0060993)3.70548381
9regulation of dendritic cell antigen processing and presentation (GO:0002604)3.62680863
10activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.61451338
11regulation of T-helper 1 cell differentiation (GO:0045625)3.52969708
12positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.51014079
13reflex (GO:0060004)3.47897415
14vitamin catabolic process (GO:0009111)3.45680876
15fat-soluble vitamin catabolic process (GO:0042363)3.45680876
16detection of other organism (GO:0098543)3.44011332
17presynaptic membrane assembly (GO:0097105)3.37256040
18regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.25570744
19synaptic transmission, glutamatergic (GO:0035249)3.21732557
20response to peptidoglycan (GO:0032494)3.17027783
21startle response (GO:0001964)3.14765835
22detection of bacterium (GO:0016045)3.13828299
23G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10958872
24detection of molecule of bacterial origin (GO:0032490)3.10117440
25ganglion development (GO:0061548)3.08979733
26natural killer cell activation involved in immune response (GO:0002323)3.06863809
27postsynaptic membrane organization (GO:0001941)3.05426022
28neuron-neuron synaptic transmission (GO:0007270)3.01367677
29adenine nucleotide transport (GO:0051503)2.99142659
30regulation of memory T cell differentiation (GO:0043380)2.93377416
31cellular anion homeostasis (GO:0030002)2.92798003
32negative regulation of T cell mediated immunity (GO:0002710)2.91357289
33cAMP catabolic process (GO:0006198)2.91155522
34righting reflex (GO:0060013)2.88780720
35neurotransmitter-gated ion channel clustering (GO:0072578)2.87540918
36cyclic nucleotide catabolic process (GO:0009214)2.85631179
37ionotropic glutamate receptor signaling pathway (GO:0035235)2.83044369
38protein localization to synapse (GO:0035418)2.82920903
39glutamate receptor signaling pathway (GO:0007215)2.82563438
40neuron cell-cell adhesion (GO:0007158)2.82140866
41positive regulation of T-helper 1 type immune response (GO:0002827)2.81935819
42cranial nerve structural organization (GO:0021604)2.81219876
43positive regulation of T-helper cell differentiation (GO:0045624)2.80995021
44G-protein coupled receptor internalization (GO:0002031)2.80323699
45L-amino acid import (GO:0043092)2.80094995
46presynaptic membrane organization (GO:0097090)2.79481317
47microglial cell activation (GO:0001774)2.78869447
48negative regulation of stem cell proliferation (GO:2000647)2.74486935
49gamma-aminobutyric acid transport (GO:0015812)2.71436670
50positive regulation of heat generation (GO:0031652)2.70347505
51purine ribonucleotide transport (GO:0015868)2.69971578
52negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66806902
53negative regulation of axon guidance (GO:1902668)2.64935957
54aggressive behavior (GO:0002118)2.62794550
55amino acid import (GO:0043090)2.61599240
56detection of external biotic stimulus (GO:0098581)2.61080303
57modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.60107966
58positive regulation by organism of defense response of other organism involved in symbiotic interact2.60107966
59modulation by symbiont of host immune response (GO:0052553)2.60107966
60positive regulation by symbiont of host defense response (GO:0052509)2.60107966
61modulation by symbiont of host defense response (GO:0052031)2.60107966
62modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.60107966
63positive regulation of monocyte chemotaxis (GO:0090026)2.59725693
64detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.59341689
65secondary metabolite biosynthetic process (GO:0044550)2.58488306
66regulation of amino acid transport (GO:0051955)2.56170181
67retina layer formation (GO:0010842)2.54122487
68limb bud formation (GO:0060174)2.54038979
69regulation of T cell chemotaxis (GO:0010819)2.50498278
70positive regulation of T cell chemotaxis (GO:0010820)2.50498278
71single strand break repair (GO:0000012)2.49047901
72negative regulation of myoblast differentiation (GO:0045662)2.48389895
73regulation of lymphocyte chemotaxis (GO:1901623)2.48238723
74neural crest cell development (GO:0014032)2.47767779
75positive regulation of antigen processing and presentation (GO:0002579)2.44933715
76regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.43045591
77purine nucleotide transport (GO:0015865)2.41138864
78positive regulation of NF-kappaB import into nucleus (GO:0042346)2.40977503
79regulation of MHC class I biosynthetic process (GO:0045343)2.40617081
80calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.40170954
81regulation of timing of cell differentiation (GO:0048505)2.40050168
82superoxide anion generation (GO:0042554)2.39988336
83estrogen biosynthetic process (GO:0006703)2.39897119
84vocalization behavior (GO:0071625)2.39630269
85positive regulation of lymphocyte migration (GO:2000403)2.39380878
86negative chemotaxis (GO:0050919)2.38568478
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.36463591
88regulation of monocyte chemotaxis (GO:0090025)2.34804821
89cell differentiation involved in metanephros development (GO:0072202)2.33120892
90serotonin receptor signaling pathway (GO:0007210)2.32555541
91axon extension involved in axon guidance (GO:0048846)2.32074596
92neuron projection extension involved in neuron projection guidance (GO:1902284)2.32074596
93regulation of T-helper 1 type immune response (GO:0002825)2.31816137
94regulation of neutrophil chemotaxis (GO:0090022)2.30800626
95regulation of neutrophil migration (GO:1902622)2.30800626
96positive regulation of smooth muscle cell migration (GO:0014911)2.30673360
97regulation of skeletal muscle contraction (GO:0014819)2.30600102
98regulation of synapse maturation (GO:0090128)2.30334816
99melanin metabolic process (GO:0006582)2.30300273
100mechanosensory behavior (GO:0007638)2.29120049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.44138402
2EZH2_22144423_ChIP-Seq_EOC_Human3.31374633
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77300163
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61524127
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.57391874
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49216642
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44186304
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.33422675
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24459216
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.23360330
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21463329
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16485208
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12270979
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11097569
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08315858
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96864155
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.94423636
18P300_19829295_ChIP-Seq_ESCs_Human1.94262952
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.91234408
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88907743
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88907743
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87203436
23VDR_22108803_ChIP-Seq_LS180_Human1.86779780
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85837955
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82571049
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81084068
27* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76352077
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74528285
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73828653
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.69886488
31TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.69601242
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69160586
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.68608963
34CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64769894
35EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.64657984
36SMAD4_21799915_ChIP-Seq_A2780_Human1.63854523
37AR_21572438_ChIP-Seq_LNCaP_Human1.63673153
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63456594
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.54877684
40ER_23166858_ChIP-Seq_MCF-7_Human1.54844223
41TAF15_26573619_Chip-Seq_HEK293_Human1.52251664
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52136782
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51954151
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51594219
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51140780
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.51093636
47P53_22387025_ChIP-Seq_ESCs_Mouse1.50693082
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.49489117
49TP53_18474530_ChIP-ChIP_U2OS_Human1.49035266
50E2F1_18555785_Chip-Seq_ESCs_Mouse1.45605588
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45037915
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42907613
53FUS_26573619_Chip-Seq_HEK293_Human1.41967868
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41825728
55AR_25329375_ChIP-Seq_VCAP_Human1.41566173
56SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41438673
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.41104066
58IGF1R_20145208_ChIP-Seq_DFB_Human1.39366739
59RNF2_27304074_Chip-Seq_NSC_Mouse1.38624643
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38229887
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.37262554
62NMYC_18555785_Chip-Seq_ESCs_Mouse1.36828188
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.35574486
64STAT3_23295773_ChIP-Seq_U87_Human1.32055479
65EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31799017
66STAT3_18555785_Chip-Seq_ESCs_Mouse1.31443555
67SOX2_18555785_Chip-Seq_ESCs_Mouse1.31058770
68REST_21632747_ChIP-Seq_MESCs_Mouse1.30695620
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28995547
70P300_18555785_Chip-Seq_ESCs_Mouse1.28839998
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28053510
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27784430
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.27008337
74TCF4_23295773_ChIP-Seq_U87_Human1.25551890
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23403597
76OCT4_18555785_Chip-Seq_ESCs_Mouse1.22073171
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21611090
78RUNX1_27457419_Chip-Seq_LIVER_Mouse1.21343313
79KDM2B_26808549_Chip-Seq_REH_Human1.19121551
80DROSHA_22980978_ChIP-Seq_HELA_Human1.19106528
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17746415
82BCAT_22108803_ChIP-Seq_LS180_Human1.16667946
83TP53_16413492_ChIP-PET_HCT116_Human1.15427625
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15411414
85AHR_22903824_ChIP-Seq_MCF-7_Human1.15280389
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.14981439
87PU1_27457419_Chip-Seq_LIVER_Mouse1.13859867
88RUNX2_22187159_ChIP-Seq_PCA_Human1.13419205
89ESRRB_18555785_Chip-Seq_ESCs_Mouse1.09151426
90ZFX_18555785_Chip-Seq_ESCs_Mouse1.08992362
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08170115
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08143297
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06993862
94SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06947846
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06492918
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06492918
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06064108
98KLF4_18555785_Chip-Seq_ESCs_Mouse1.05996384
99FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05934846
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04985022

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.63663911
2MP0005409_darkened_coat_color4.49344572
3MP0009697_abnormal_copulation3.60025741
4MP0005171_absent_coat_pigmentation3.23436191
5MP0006292_abnormal_olfactory_placode3.06220841
6MP0003880_abnormal_central_pattern3.02986592
7MP0005670_abnormal_white_adipose2.80503235
8MP0002735_abnormal_chemical_nociception2.66579562
9MP0000566_synostosis2.56933829
10MP0000372_irregular_coat_pigmentation2.47548698
11MP0001188_hyperpigmentation2.42044992
12MP0002638_abnormal_pupillary_reflex2.29206160
13MP0002876_abnormal_thyroid_physiology2.17694559
14MP0002736_abnormal_nociception_after2.11854605
15MP0002102_abnormal_ear_morphology2.11772734
16MP0005646_abnormal_pituitary_gland2.04958554
17MP0001502_abnormal_circadian_rhythm2.03498785
18MP0001968_abnormal_touch/_nociception1.96658159
19MP0001486_abnormal_startle_reflex1.93966210
20MP0004859_abnormal_synaptic_plasticity1.93791400
21MP0002734_abnormal_mechanical_nocicepti1.88841019
22MP0003787_abnormal_imprinting1.83096562
23MP0006276_abnormal_autonomic_nervous1.71425836
24MP0000015_abnormal_ear_pigmentation1.62922835
25MP0004270_analgesia1.60706765
26MP0005451_abnormal_body_composition1.57513424
27MP0009745_abnormal_behavioral_response1.57086610
28MP0005645_abnormal_hypothalamus_physiol1.47095225
29MP0001984_abnormal_olfaction1.46214973
30MP0002063_abnormal_learning/memory/cond1.45922041
31MP0003635_abnormal_synaptic_transmissio1.43279728
32MP0003690_abnormal_glial_cell1.40718548
33MP0001440_abnormal_grooming_behavior1.40301813
34MP0010386_abnormal_urinary_bladder1.37279079
35MP0000778_abnormal_nervous_system1.35212880
36MP0002572_abnormal_emotion/affect_behav1.34844869
37MP0001501_abnormal_sleep_pattern1.33063960
38MP0002064_seizures1.31217559
39MP0000678_abnormal_parathyroid_gland1.29163913
40MP0008057_abnormal_DNA_replication1.29072126
41MP0001177_atelectasis1.29049251
42MP0005503_abnormal_tendon_morphology1.27373408
43MP0001346_abnormal_lacrimal_gland1.25634565
44MP0009384_cardiac_valve_regurgitation1.19255788
45MP0002277_abnormal_respiratory_mucosa1.16446449
46MP0005551_abnormal_eye_electrophysiolog1.15626024
47MP0004147_increased_porphyrin_level1.14658720
48MP0002272_abnormal_nervous_system1.12072615
49MP0004742_abnormal_vestibular_system1.09891988
50MP0005394_taste/olfaction_phenotype1.09700471
51MP0005499_abnormal_olfactory_system1.09700471
52MP0000049_abnormal_middle_ear1.08278059
53MP0004145_abnormal_muscle_electrophysio1.06941510
54MP0001970_abnormal_pain_threshold1.02459059
55MP0001963_abnormal_hearing_physiology1.02157530
56MP0005386_behavior/neurological_phenoty1.00921879
57MP0004924_abnormal_behavior1.00921879
58MP0002733_abnormal_thermal_nociception0.97957969
59MP0008789_abnormal_olfactory_epithelium0.97159170
60MP0005623_abnormal_meninges_morphology0.95540705
61MP0000026_abnormal_inner_ear0.95521194
62MP0002557_abnormal_social/conspecific_i0.94372561
63MP0002067_abnormal_sensory_capabilities0.94254045
64MP0001879_abnormal_lymphatic_vessel0.93637729
65MP0000762_abnormal_tongue_morphology0.93130905
66MP0009785_altered_susceptibility_to0.92266452
67MP0002009_preneoplasia0.89657186
68MP0009046_muscle_twitch0.87804163
69MP0009764_decreased_sensitivity_to0.87470490
70MP0003279_aneurysm0.86733788
71MP0002148_abnormal_hypersensitivity_rea0.86283129
72MP0004142_abnormal_muscle_tone0.86195104
73MP0003724_increased_susceptibility_to0.85088357
74MP0008260_abnormal_autophagy0.85026474
75MP0001986_abnormal_taste_sensitivity0.83828465
76MP0002089_abnormal_postnatal_growth/wei0.83230482
77MP0002127_abnormal_cardiovascular_syste0.82871414
78MP0004381_abnormal_hair_follicle0.81146102
79MP0000579_abnormal_nail_morphology0.81078221
80MP0001186_pigmentation_phenotype0.78581822
81MP0005253_abnormal_eye_physiology0.77778123
82MP0002938_white_spotting0.77395283
83MP0005410_abnormal_fertilization0.74801666
84MP0002177_abnormal_outer_ear0.73994652
85MP0002998_abnormal_bone_remodeling0.73197233
86MP0005257_abnormal_intraocular_pressure0.73123136
87MP0000631_abnormal_neuroendocrine_gland0.71352554
88MP0008569_lethality_at_weaning0.71233098
89MP0005647_abnormal_sex_gland0.70838852
90MP0002160_abnormal_reproductive_system0.70054554
91MP0003195_calcinosis0.67119717
92MP0003137_abnormal_impulse_conducting0.64865278
93MP0002184_abnormal_innervation0.62880601
94MP0005423_abnormal_somatic_nervous0.62808983
95MP0004215_abnormal_myocardial_fiber0.62579842
96MP0003941_abnormal_skin_development0.60749255
97MP0002075_abnormal_coat/hair_pigmentati0.59804608
98MP0001905_abnormal_dopamine_level0.59251592
99MP0000681_abnormal_thyroid_gland0.59187395
100MP0004782_abnormal_surfactant_physiolog0.57788708

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)4.32081221
2Follicular hyperkeratosis (HP:0007502)3.98152223
3Aplasia/Hypoplasia of the fovea (HP:0008060)3.67664882
4Hypoplasia of the fovea (HP:0007750)3.67664882
5Focal motor seizures (HP:0011153)3.59755637
6Chronic hepatic failure (HP:0100626)3.56082624
7Febrile seizures (HP:0002373)3.52932774
8Abnormality of incisor morphology (HP:0011063)3.32811723
9Abnormality of the axillary hair (HP:0100134)3.22586672
10Abnormality of secondary sexual hair (HP:0009888)3.22586672
11Osteomalacia (HP:0002749)3.21366659
12Blue irides (HP:0000635)3.14832455
13Enlarged kidneys (HP:0000105)3.06909245
14Abnormality of molar (HP:0011077)3.00485147
15Abnormality of molar morphology (HP:0011070)3.00485147
16Abnormality of the fovea (HP:0000493)2.96139086
17Abnormality of permanent molar morphology (HP:0011071)2.87649555
18Abnormality of the dental root (HP:0006486)2.87649555
19Taurodontia (HP:0000679)2.87649555
20Abnormality of calcium-phosphate metabolism (HP:0100530)2.82907933
21Atelectasis (HP:0100750)2.81564793
22Retrobulbar optic neuritis (HP:0100654)2.77513675
23Optic neuritis (HP:0100653)2.77513675
24Dynein arm defect of respiratory motile cilia (HP:0012255)2.75254259
25Absent/shortened dynein arms (HP:0200106)2.75254259
26Hyperphosphatemia (HP:0002905)2.70782637
27Hypothermia (HP:0002045)2.66167060
28Epileptic encephalopathy (HP:0200134)2.62595674
29Abnormality of the dental pulp (HP:0006479)2.61658249
30Aplasia cutis congenita (HP:0001057)2.59665070
31Fair hair (HP:0002286)2.56183303
32Tetany (HP:0001281)2.48610250
33Birth length less than 3rd percentile (HP:0003561)2.44545969
34Retinal dysplasia (HP:0007973)2.44288534
35Pheochromocytoma (HP:0002666)2.43040034
36Abnormal hair whorl (HP:0010721)2.41780437
37Occipital encephalocele (HP:0002085)2.39997181
38Aplasia/Hypoplasia of the macula (HP:0008059)2.33083274
39Hyperventilation (HP:0002883)2.32183270
40True hermaphroditism (HP:0010459)2.30703789
41Corneal dystrophy (HP:0001131)2.30079195
42Short middle phalanx of the 5th finger (HP:0004220)2.29070055
43Aplasia of the phalanges of the hand (HP:0009802)2.25872091
44Aplasia involving bones of the extremities (HP:0009825)2.25872091
45Aplasia involving bones of the upper limbs (HP:0009823)2.25872091
46Methylmalonic acidemia (HP:0002912)2.24834083
47Abnormality of the nasal septum (HP:0000419)2.22853505
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22562424
49Optic nerve hypoplasia (HP:0000609)2.22459357
50Conical tooth (HP:0000698)2.20790467
51Hypoplastic left heart (HP:0004383)2.17099476
52Mixed hearing impairment (HP:0000410)2.14993032
53Symptomatic seizures (HP:0011145)2.14231356
54Keratitis (HP:0000491)2.11577718
55Onycholysis (HP:0001806)2.06577852
56Abnormality of homocysteine metabolism (HP:0010919)2.05480839
57Homocystinuria (HP:0002156)2.05480839
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.05249239
59Generalized hypopigmentation of hair (HP:0011358)2.04831654
60Protruding tongue (HP:0010808)2.04013213
61Neuroendocrine neoplasm (HP:0100634)1.98944509
62Medial flaring of the eyebrow (HP:0010747)1.95408010
63Aplasia/Hypoplasia of the lens (HP:0008063)1.95026594
64Abnormality of dental color (HP:0011073)1.94195022
65Narrow nasal bridge (HP:0000446)1.94189158
66Tubulointerstitial nephritis (HP:0001970)1.94186088
67Anomalous pulmonary venous return (HP:0010772)1.93662070
68White forelock (HP:0002211)1.93433817
69Orchitis (HP:0100796)1.92689252
70Hypocalcemia (HP:0002901)1.90923496
71Hypoplastic heart (HP:0001961)1.90496106
72Abnormality of the phalanges of the 5th finger (HP:0004213)1.88633390
73Abnormality of the pulmonary veins (HP:0011718)1.86763475
74Hypoplasia of dental enamel (HP:0006297)1.85733949
75Dry hair (HP:0011359)1.85194873
76Congenital sensorineural hearing impairment (HP:0008527)1.84554369
77Decreased central vision (HP:0007663)1.84328582
78Nonprogressive disorder (HP:0003680)1.82295339
79Patchy hypopigmentation of hair (HP:0011365)1.80718018
80Bell-shaped thorax (HP:0001591)1.80711948
81Aortic valve stenosis (HP:0001650)1.80521683
82Tented upper lip vermilion (HP:0010804)1.79684855
83Hypomagnesemia (HP:0002917)1.78820649
84Congenital hepatic fibrosis (HP:0002612)1.78277244
85Aplasia/Hypoplasia affecting the retina (HP:0008061)1.77767456
86Small hand (HP:0200055)1.73902418
87Ectropion (HP:0000656)1.73222789
88Recurrent cutaneous fungal infections (HP:0011370)1.72808551
89Chronic mucocutaneous candidiasis (HP:0002728)1.72808551
90Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.72373441
91Abnormal respiratory motile cilium morphology (HP:0005938)1.71140339
92Abnormal respiratory epithelium morphology (HP:0012253)1.71140339
93Focal seizures (HP:0007359)1.71010686
94Congenital stationary night blindness (HP:0007642)1.67758284
95Nephrogenic diabetes insipidus (HP:0009806)1.67696290
96Popliteal pterygium (HP:0009756)1.66541999
97Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65339930
98Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.63899855
99Prolonged partial thromboplastin time (HP:0003645)1.63413462
100Absent speech (HP:0001344)1.62002373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK7.85404822
2MKNK25.61258881
3CASK4.86837268
4MKNK13.23103092
5SRPK12.55524952
6PRPF4B2.20569986
7AKT32.11922313
8MAP2K72.03530235
9ZAK2.03381342
10TNK22.02171343
11MAPK131.65851349
12ERBB31.65787567
13MAP3K141.62059557
14PLK21.54367257
15NTRK31.52180258
16GRK71.42609684
17TXK1.30913472
18EPHA41.28802336
19EIF2AK21.28754477
20PIK3CA1.25272743
21BMPR21.24151091
22MAP2K61.21878599
23NEK61.21791233
24MARK11.17718799
25BMPR1B1.17294406
26NUAK11.13149258
27MUSK1.12109226
28IRAK31.09163849
29PRKCG1.08658539
30INSRR1.08262821
31YES11.05143204
32CDK30.97195821
33TAOK20.96317672
34STK38L0.94138526
35GRK50.91309121
36PIK3CG0.88043766
37NTRK20.87198140
38SGK20.85850133
39IRAK40.85066445
40PRKCE0.83774271
41DYRK1A0.83354305
42FES0.78149473
43STK240.74759206
44FGFR20.74232567
45PTK2B0.72941430
46CAMK2B0.71974392
47SGK30.71758516
48MAPK70.69163395
49PKN10.67210536
50CAMK2A0.64717478
51ADRBK20.63043976
52TRPM70.62616985
53PDK20.61193351
54MAP3K60.59667128
55SGK4940.56587934
56SGK2230.56587934
57PLK40.55994287
58CLK10.53979530
59MAPK120.53821008
60GRK10.53666417
61PINK10.53565338
62CAMK10.52615205
63CAMK2D0.52287994
64MAP2K40.50111928
65CAMK2G0.49984270
66PRKAA20.48697012
67PHKG20.48280779
68PHKG10.48280779
69IKBKB0.47177032
70SGK10.46404236
71MAP3K120.43758330
72WNK30.42995344
73LATS10.42688115
74TIE10.41125949
75IGF1R0.39581976
76PRKACB0.38888029
77CSNK1A10.36231118
78PRKACA0.35319387
79ACVR1B0.34096205
80PRKCA0.33620327
81RPS6KB10.32578289
82VRK10.31976073
83PRKG20.31723574
84EPHB20.31329972
85DAPK20.30972256
86FGR0.30559388
87ADRBK10.30491949
88CHUK0.29211816
89PRKG10.28706821
90LYN0.28465012
91FER0.28326193
92NLK0.27540605
93PRKCB0.26946885
94FRK0.26088726
95TEC0.25182345
96DYRK20.24989910
97CDK50.24757522
98PRKACG0.24006989
99PAK30.23400137
100MAP3K40.22042356

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.71336280
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.52047266
3Autoimmune thyroid disease_Homo sapiens_hsa053202.39358390
4Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.24351982
5Graft-versus-host disease_Homo sapiens_hsa053322.24001945
6Olfactory transduction_Homo sapiens_hsa047402.12604426
7Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.09937723
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.06717866
9Morphine addiction_Homo sapiens_hsa050322.00013767
10Rheumatoid arthritis_Homo sapiens_hsa053231.99522639
11Circadian rhythm_Homo sapiens_hsa047101.95586253
12Steroid biosynthesis_Homo sapiens_hsa001001.95469099
13Circadian entrainment_Homo sapiens_hsa047131.94472279
14Glutamatergic synapse_Homo sapiens_hsa047241.73818233
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71048465
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70907851
17Synaptic vesicle cycle_Homo sapiens_hsa047211.65725040
18Taste transduction_Homo sapiens_hsa047421.59954460
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.54939035
20Type I diabetes mellitus_Homo sapiens_hsa049401.53367152
21Allograft rejection_Homo sapiens_hsa053301.52422243
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42786402
23Serotonergic synapse_Homo sapiens_hsa047261.42040309
24Calcium signaling pathway_Homo sapiens_hsa040201.39806084
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37045019
26GABAergic synapse_Homo sapiens_hsa047271.35426013
27Amphetamine addiction_Homo sapiens_hsa050311.34420815
28Insulin secretion_Homo sapiens_hsa049111.33243275
29Arachidonic acid metabolism_Homo sapiens_hsa005901.33039204
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32420844
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.30682065
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28934115
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28590372
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.23885270
35Phototransduction_Homo sapiens_hsa047441.22077061
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21196654
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21091498
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19986951
39Regulation of autophagy_Homo sapiens_hsa041401.14693909
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09739248
41Hematopoietic cell lineage_Homo sapiens_hsa046401.09429152
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08509529
43Collecting duct acid secretion_Homo sapiens_hsa049661.07143147
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04418579
45Inositol phosphate metabolism_Homo sapiens_hsa005621.04298709
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03989436
47Axon guidance_Homo sapiens_hsa043600.99385344
48Ovarian steroidogenesis_Homo sapiens_hsa049130.95696241
49Phagosome_Homo sapiens_hsa041450.93501877
50Vitamin digestion and absorption_Homo sapiens_hsa049770.91302988
51Cocaine addiction_Homo sapiens_hsa050300.90075680
52Salivary secretion_Homo sapiens_hsa049700.89531786
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85356573
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84513728
55Tuberculosis_Homo sapiens_hsa051520.83956746
56cAMP signaling pathway_Homo sapiens_hsa040240.82150547
57Cholinergic synapse_Homo sapiens_hsa047250.81073206
58Dopaminergic synapse_Homo sapiens_hsa047280.80123141
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79681661
60Staphylococcus aureus infection_Homo sapiens_hsa051500.76797464
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75421125
62Sphingolipid metabolism_Homo sapiens_hsa006000.75274353
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.73707522
64TNF signaling pathway_Homo sapiens_hsa046680.73509026
65Long-term depression_Homo sapiens_hsa047300.73291424
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.72281107
67Arginine and proline metabolism_Homo sapiens_hsa003300.70896920
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69367510
69Fatty acid biosynthesis_Homo sapiens_hsa000610.68334786
70African trypanosomiasis_Homo sapiens_hsa051430.66204779
71Melanoma_Homo sapiens_hsa052180.66118417
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61391836
73Dilated cardiomyopathy_Homo sapiens_hsa054140.60391340
74Renin secretion_Homo sapiens_hsa049240.58956804
75Phenylalanine metabolism_Homo sapiens_hsa003600.57573065
76ECM-receptor interaction_Homo sapiens_hsa045120.56730172
77Measles_Homo sapiens_hsa051620.56715529
78Retinol metabolism_Homo sapiens_hsa008300.56545282
79Malaria_Homo sapiens_hsa051440.56535191
80Rap1 signaling pathway_Homo sapiens_hsa040150.55479444
81Herpes simplex infection_Homo sapiens_hsa051680.52814423
82Salmonella infection_Homo sapiens_hsa051320.51204034
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50605402
84Mineral absorption_Homo sapiens_hsa049780.48629713
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.48005260
86Ras signaling pathway_Homo sapiens_hsa040140.46522018
87Leishmaniasis_Homo sapiens_hsa051400.46383349
88Oxytocin signaling pathway_Homo sapiens_hsa049210.44169386
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43986236
90Sulfur metabolism_Homo sapiens_hsa009200.43435892
91Vibrio cholerae infection_Homo sapiens_hsa051100.41865181
92Renin-angiotensin system_Homo sapiens_hsa046140.40992967
93Wnt signaling pathway_Homo sapiens_hsa043100.40407159
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39956313
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39021406
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39013582
97Chemokine signaling pathway_Homo sapiens_hsa040620.38933991
98Asthma_Homo sapiens_hsa053100.35830706
99MAPK signaling pathway_Homo sapiens_hsa040100.32766876
100Long-term potentiation_Homo sapiens_hsa047200.32645761

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »