RGS7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.86023750
2synaptic vesicle exocytosis (GO:0016079)5.53518393
3vocalization behavior (GO:0071625)5.42518708
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.40261335
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.28742299
6synaptic vesicle maturation (GO:0016188)5.26718479
7glutamate secretion (GO:0014047)5.25493240
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.13875957
9protein localization to synapse (GO:0035418)5.09417908
10neuron cell-cell adhesion (GO:0007158)5.05385360
11locomotory exploration behavior (GO:0035641)5.05248889
12regulation of synaptic vesicle exocytosis (GO:2000300)4.88773900
13regulation of glutamate receptor signaling pathway (GO:1900449)4.81481879
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.78636151
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.59753607
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.58511249
17regulation of synaptic vesicle transport (GO:1902803)4.38704801
18glutamate receptor signaling pathway (GO:0007215)4.37368687
19neuronal action potential propagation (GO:0019227)4.35284206
20exploration behavior (GO:0035640)4.29681081
21neurotransmitter secretion (GO:0007269)4.25972833
22synaptic transmission, glutamatergic (GO:0035249)4.22514658
23presynaptic membrane assembly (GO:0097105)4.11542593
24neurotransmitter-gated ion channel clustering (GO:0072578)4.07060172
25neuron-neuron synaptic transmission (GO:0007270)4.02681774
26regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.01914459
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.01022478
28regulation of neuronal synaptic plasticity (GO:0048168)3.98844402
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.98547846
30postsynaptic membrane organization (GO:0001941)3.87572883
31gamma-aminobutyric acid transport (GO:0015812)3.86957979
32synaptic vesicle endocytosis (GO:0048488)3.85458229
33G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.83609143
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.82265377
35cellular potassium ion homeostasis (GO:0030007)3.82103379
36positive regulation of synapse maturation (GO:0090129)3.79284550
37layer formation in cerebral cortex (GO:0021819)3.75888496
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.73036594
39regulation of postsynaptic membrane potential (GO:0060078)3.72019904
40L-amino acid import (GO:0043092)3.71638972
41regulation of synapse structural plasticity (GO:0051823)3.70856507
42proline transport (GO:0015824)3.69174335
43long-term memory (GO:0007616)3.68454907
44neuron recognition (GO:0008038)3.66245623
45presynaptic membrane organization (GO:0097090)3.65395396
46positive regulation of membrane potential (GO:0045838)3.65061893
47negative regulation of dendrite morphogenesis (GO:0050774)3.64982184
48potassium ion homeostasis (GO:0055075)3.63096234
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58247554
50regulation of neurotransmitter secretion (GO:0046928)3.54960195
51neurotransmitter transport (GO:0006836)3.53887443
52dendritic spine morphogenesis (GO:0060997)3.51479035
53long-term synaptic potentiation (GO:0060291)3.48010073
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47276499
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.46215299
56neuronal ion channel clustering (GO:0045161)3.44455563
57regulation of synaptic plasticity (GO:0048167)3.43699032
58cerebellar Purkinje cell differentiation (GO:0021702)3.43383699
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.43044275
60regulation of vesicle fusion (GO:0031338)3.41511024
61axonal fasciculation (GO:0007413)3.36345411
62positive regulation of dendritic spine development (GO:0060999)3.34155832
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.33166002
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.33135525
65regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.32295400
66cerebellar granule cell differentiation (GO:0021707)3.29001316
67amino acid import (GO:0043090)3.28573428
68negative regulation of dendrite development (GO:2000171)3.28442114
69membrane hyperpolarization (GO:0060081)3.27047887
70positive regulation of neurotransmitter secretion (GO:0001956)3.26256373
71innervation (GO:0060384)3.24520042
72membrane depolarization during action potential (GO:0086010)3.24454147
73regulation of neurotransmitter transport (GO:0051588)3.23794149
74transmission of nerve impulse (GO:0019226)3.23755573
75regulation of neurotransmitter levels (GO:0001505)3.23193870
76cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.21911681
77membrane depolarization (GO:0051899)3.20655849
78response to histamine (GO:0034776)3.20652562
79potassium ion import (GO:0010107)3.18498380
80activation of protein kinase A activity (GO:0034199)3.17439795
81regulation of dendritic spine morphogenesis (GO:0061001)3.17183466
82serotonin metabolic process (GO:0042428)3.15671605
83dendrite morphogenesis (GO:0048813)3.14657832
84regulation of calcium ion-dependent exocytosis (GO:0017158)3.14043932
85sodium ion export (GO:0071436)3.13689417
86synapse assembly (GO:0007416)3.11276529
87cell migration in hindbrain (GO:0021535)3.11011381
88positive regulation of neurotransmitter transport (GO:0051590)3.10960049
89cellular sodium ion homeostasis (GO:0006883)3.10194262
90positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09753935
91response to pheromone (GO:0019236)3.08419487
92auditory behavior (GO:0031223)3.05447597
93regulation of synapse maturation (GO:0090128)3.04546857
94response to auditory stimulus (GO:0010996)3.03630194
95cell communication by electrical coupling (GO:0010644)3.03427738
96signal release (GO:0023061)3.03338829
97synaptic vesicle transport (GO:0048489)3.02470650
98establishment of synaptic vesicle localization (GO:0097480)3.02470650
99learning (GO:0007612)3.00734445
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98682421
101synaptic transmission (GO:0007268)2.98524748
102neuromuscular process controlling posture (GO:0050884)2.98056317
103positive regulation of synaptic transmission (GO:0050806)2.97311757
104positive regulation of dendritic spine morphogenesis (GO:0061003)2.95605115
105regulation of synaptic transmission (GO:0050804)2.94747835
106dendritic spine organization (GO:0097061)2.93959118
107regulation of respiratory system process (GO:0044065)2.93849454
108neuromuscular synaptic transmission (GO:0007274)2.92974782
109neurotransmitter uptake (GO:0001504)2.91305856
110regulation of voltage-gated calcium channel activity (GO:1901385)2.91100073
111adult walking behavior (GO:0007628)2.90384386
112behavioral response to cocaine (GO:0048148)2.90288115
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90278046
114regulation of dendritic spine development (GO:0060998)2.90213100
115behavioral fear response (GO:0001662)2.89301036
116behavioral defense response (GO:0002209)2.89301036
117startle response (GO:0001964)2.89242544
118intraspecies interaction between organisms (GO:0051703)2.89054320
119social behavior (GO:0035176)2.89054320
120vesicle transport along microtubule (GO:0047496)2.88205306
121detection of calcium ion (GO:0005513)2.88128253
122regulation of exocytosis (GO:0017157)2.87973851
123fear response (GO:0042596)2.86478540

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.98284690
2GBX2_23144817_ChIP-Seq_PC3_Human3.99776950
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10165172
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99658273
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98779298
6REST_21632747_ChIP-Seq_MESCs_Mouse2.67787825
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57527985
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57527985
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57258842
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54686511
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52088702
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.46872450
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41731537
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41221233
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38910944
16DROSHA_22980978_ChIP-Seq_HELA_Human2.33040610
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.30055138
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.25313639
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24278691
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12338293
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11556363
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.08598858
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.08428130
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06463276
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99293073
26AR_21572438_ChIP-Seq_LNCaP_Human1.95238316
27TAF15_26573619_Chip-Seq_HEK293_Human1.86973817
28* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82718567
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81159116
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80008163
31SMAD4_21799915_ChIP-Seq_A2780_Human1.77928532
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77507611
33* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73667690
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71311583
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63456934
36P300_19829295_ChIP-Seq_ESCs_Human1.59033946
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58211528
38* SMAD_19615063_ChIP-ChIP_OVARY_Human1.52612925
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47479702
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.46005635
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45808292
42ZNF274_21170338_ChIP-Seq_K562_Hela1.42551088
43* SMAD3_21741376_ChIP-Seq_EPCs_Human1.41781625
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41060786
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.40916738
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.40500899
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39490860
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37810261
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.37387516
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37018759
51AR_25329375_ChIP-Seq_VCAP_Human1.36967700
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36798606
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36368244
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34207228
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33840895
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33636066
57* STAT3_23295773_ChIP-Seq_U87_Human1.33559607
58IGF1R_20145208_ChIP-Seq_DFB_Human1.33392202
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30230320
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.28809475
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25159952
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22895279
63* RING1B_27294783_Chip-Seq_ESCs_Mouse1.20850119
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20554801
65* AR_19668381_ChIP-Seq_PC3_Human1.20170683
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19889861
67RNF2_27304074_Chip-Seq_NSC_Mouse1.18929632
68* TCF4_23295773_ChIP-Seq_U87_Human1.17643722
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16392367
70* FUS_26573619_Chip-Seq_HEK293_Human1.15652399
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15181171
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.13120270
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12460085
74* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11517805
75AHR_22903824_ChIP-Seq_MCF-7_Human1.10235290
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08205517
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08196232
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.07561912
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06538360
80* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05231205
81* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05231205
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04935813
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04064510
84RUNX2_22187159_ChIP-Seq_PCA_Human1.04001146
85* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03210654
86KDM2B_26808549_Chip-Seq_REH_Human1.02767058
87* RING1B_27294783_Chip-Seq_NPCs_Mouse1.02314484
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01281725
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00901564
90* NANOG_18555785_Chip-Seq_ESCs_Mouse1.00514789
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00234753
92VDR_22108803_ChIP-Seq_LS180_Human1.00016875
93ER_23166858_ChIP-Seq_MCF-7_Human0.99516955
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97617903
95FLI1_21867929_ChIP-Seq_TH2_Mouse0.97079527
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.96971267
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96345844
98TP53_18474530_ChIP-ChIP_U2OS_Human0.95807064
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95196200
100BCAT_22108803_ChIP-Seq_LS180_Human0.94395967
101JUN_21703547_ChIP-Seq_K562_Human0.93997706
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.93455355
103TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92912893
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92793253
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92538899
106* SOX9_26525672_Chip-Seq_HEART_Mouse0.91668611
107* TP53_16413492_ChIP-PET_HCT116_Human0.90750690
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90436227
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90356741
110SMAD3_21741376_ChIP-Seq_HESCs_Human0.89986609
111DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89326261
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88444673
113CBP_20019798_ChIP-Seq_JUKART_Human0.86235506

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.86711595
2MP0003880_abnormal_central_pattern4.88779495
3MP0003635_abnormal_synaptic_transmissio3.99439044
4MP0004270_analgesia3.75260158
5MP0001968_abnormal_touch/_nociception3.33864468
6MP0009745_abnormal_behavioral_response3.31121713
7* MP0002063_abnormal_learning/memory/cond3.19579255
8MP0005423_abnormal_somatic_nervous3.10143118
9MP0002064_seizures3.06429561
10MP0009046_muscle_twitch3.02221766
11* MP0002572_abnormal_emotion/affect_behav2.76984473
12MP0002734_abnormal_mechanical_nocicepti2.74305340
13MP0002736_abnormal_nociception_after2.63721693
14MP0002272_abnormal_nervous_system2.59766168
15MP0001486_abnormal_startle_reflex2.58315831
16MP0002735_abnormal_chemical_nociception2.52792625
17MP0002822_catalepsy2.39553089
18MP0001501_abnormal_sleep_pattern2.37679483
19MP0009780_abnormal_chondrocyte_physiolo2.18627964
20MP0002067_abnormal_sensory_capabilities2.14933218
21MP0001440_abnormal_grooming_behavior2.12329416
22MP0002733_abnormal_thermal_nociception2.12200273
23MP0001984_abnormal_olfaction2.05050179
24MP0001970_abnormal_pain_threshold1.99613146
25MP0000778_abnormal_nervous_system1.88524347
26MP0006276_abnormal_autonomic_nervous1.87667579
27MP0002184_abnormal_innervation1.87097702
28MP0002557_abnormal_social/conspecific_i1.81750282
29MP0008569_lethality_at_weaning1.81722042
30MP0004924_abnormal_behavior1.81303983
31MP0005386_behavior/neurological_phenoty1.81303983
32MP0005646_abnormal_pituitary_gland1.77546726
33MP0002909_abnormal_adrenal_gland1.74128252
34MP0004811_abnormal_neuron_physiology1.61786488
35MP0003329_amyloid_beta_deposits1.59426939
36MP0001188_hyperpigmentation1.57284312
37MP0004858_abnormal_nervous_system1.57197957
38MP0001502_abnormal_circadian_rhythm1.55275267
39MP0003879_abnormal_hair_cell1.51796102
40MP0000955_abnormal_spinal_cord1.47033851
41MP0003787_abnormal_imprinting1.45651416
42MP0002882_abnormal_neuron_morphology1.42549101
43MP0005645_abnormal_hypothalamus_physiol1.40882426
44MP0001529_abnormal_vocalization1.40548590
45MP0003633_abnormal_nervous_system1.37148974
46* MP0002066_abnormal_motor_capabilities/c1.35966332
47MP0008877_abnormal_DNA_methylation1.33207629
48MP0001905_abnormal_dopamine_level1.31375687
49* MP0005551_abnormal_eye_electrophysiolog1.31031603
50MP0004142_abnormal_muscle_tone1.30078794
51MP0010386_abnormal_urinary_bladder1.28855761
52MP0004885_abnormal_endolymph1.25504860
53MP0003123_paternal_imprinting1.22077862
54MP0003121_genomic_imprinting1.18932963
55MP0003631_nervous_system_phenotype1.13486024
56MP0003122_maternal_imprinting1.09718211
57MP0002152_abnormal_brain_morphology1.08962306
58MP0004145_abnormal_muscle_electrophysio1.04728047
59MP0002229_neurodegeneration1.03872911
60MP0004147_increased_porphyrin_level1.00100311
61MP0001986_abnormal_taste_sensitivity0.99268451
62MP0004742_abnormal_vestibular_system0.97172458
63MP0000631_abnormal_neuroendocrine_gland0.96601943
64MP0003283_abnormal_digestive_organ0.96172741
65MP0002069_abnormal_eating/drinking_beha0.94900314
66MP0008872_abnormal_physiological_respon0.93809005
67MP0004215_abnormal_myocardial_fiber0.92967635
68MP0005535_abnormal_body_temperature0.91697039
69MP0002090_abnormal_vision0.89227188
70MP0001963_abnormal_hearing_physiology0.87004113
71MP0002638_abnormal_pupillary_reflex0.86013127
72MP0005499_abnormal_olfactory_system0.85997583
73MP0005394_taste/olfaction_phenotype0.85997583
74MP0000751_myopathy0.85881538
75MP0002752_abnormal_somatic_nervous0.85800453
76MP0000569_abnormal_digit_pigmentation0.84745993
77MP0004085_abnormal_heartbeat0.84110441
78MP0005379_endocrine/exocrine_gland_phen0.81947100
79MP0008874_decreased_physiological_sensi0.79919232
80MP0002837_dystrophic_cardiac_calcinosis0.79572452
81MP0003634_abnormal_glial_cell0.79016470
82MP0005187_abnormal_penis_morphology0.77635198
83MP0001177_atelectasis0.76974495
84MP0008961_abnormal_basal_metabolism0.75753433
85MP0000013_abnormal_adipose_tissue0.73349131
86MP0002876_abnormal_thyroid_physiology0.73224468
87MP0003632_abnormal_nervous_system0.72713398
88MP0005409_darkened_coat_color0.71101570
89MP0006072_abnormal_retinal_apoptosis0.71064284
90MP0004484_altered_response_of0.70108049
91MP0003690_abnormal_glial_cell0.68652605
92MP0005253_abnormal_eye_physiology0.67093242
93MP0001664_abnormal_digestion0.66538410
94MP0001485_abnormal_pinna_reflex0.65726531
95MP0003137_abnormal_impulse_conducting0.64901884
96MP0000639_abnormal_adrenal_gland0.61932379
97MP0000604_amyloidosis0.60678271
98MP0004233_abnormal_muscle_weight0.60166311
99MP0001944_abnormal_pancreas_morphology0.60164093
100MP0006292_abnormal_olfactory_placode0.59252385
101MP0000920_abnormal_myelination0.58993322
102MP0003183_abnormal_peptide_metabolism0.55296397
103MP0003075_altered_response_to0.54949436
104MP0004043_abnormal_pH_regulation0.54323549
105MP0001943_abnormal_respiration0.54247071
106MP0010768_mortality/aging0.54203715
107MP0001299_abnormal_eye_distance/0.54139852
108MP0010769_abnormal_survival0.53379587
109MP0003861_abnormal_nervous_system0.53107292
110MP0002082_postnatal_lethality0.53063966
111MP0010770_preweaning_lethality0.53063966
112MP0005623_abnormal_meninges_morphology0.52699433

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.82422646
2Myokymia (HP:0002411)6.11473883
3Epileptic encephalopathy (HP:0200134)5.77753012
4Focal seizures (HP:0007359)5.65887512
5Febrile seizures (HP:0002373)5.02641334
6Visual hallucinations (HP:0002367)5.01495283
7Progressive cerebellar ataxia (HP:0002073)4.64673894
8Atonic seizures (HP:0010819)4.62316678
9Absence seizures (HP:0002121)4.34587865
10Hyperventilation (HP:0002883)4.27118179
11Dialeptic seizures (HP:0011146)4.01162573
12Broad-based gait (HP:0002136)3.95518570
13Generalized tonic-clonic seizures (HP:0002069)3.91650490
14Action tremor (HP:0002345)3.74519699
15Poor eye contact (HP:0000817)3.49786551
16Gaze-evoked nystagmus (HP:0000640)3.47261533
17Supranuclear gaze palsy (HP:0000605)3.24332267
18Amblyopia (HP:0000646)3.19634230
19Dysdiadochokinesis (HP:0002075)3.12726368
20Impaired social interactions (HP:0000735)3.12636464
21Abnormal social behavior (HP:0012433)3.12636464
22Excessive salivation (HP:0003781)3.08409056
23Drooling (HP:0002307)3.08409056
24Ankle clonus (HP:0011448)3.07344510
25Truncal ataxia (HP:0002078)3.00766350
26Depression (HP:0000716)2.98627661
27Impaired vibration sensation in the lower limbs (HP:0002166)2.98473107
28Dysmetria (HP:0001310)2.91389252
29Anxiety (HP:0000739)2.81188649
30Epileptiform EEG discharges (HP:0011182)2.80246085
31Abnormal eating behavior (HP:0100738)2.74215827
32Urinary bladder sphincter dysfunction (HP:0002839)2.74068302
33Genetic anticipation (HP:0003743)2.72366927
34Postural instability (HP:0002172)2.66432793
35Scanning speech (HP:0002168)2.64087126
36EEG with generalized epileptiform discharges (HP:0011198)2.63856675
37Absent speech (HP:0001344)2.63101820
38Mutism (HP:0002300)2.62608882
39Progressive inability to walk (HP:0002505)2.61784467
40Inability to walk (HP:0002540)2.58830013
41Protruding tongue (HP:0010808)2.58234623
42Hemiparesis (HP:0001269)2.56135655
43Impaired smooth pursuit (HP:0007772)2.52764117
44Cerebral hypomyelination (HP:0006808)2.49331973
45Sleep apnea (HP:0010535)2.46854754
46Stereotypic behavior (HP:0000733)2.42426921
47Hypsarrhythmia (HP:0002521)2.41902399
48Delusions (HP:0000746)2.41887529
49Abnormality of binocular vision (HP:0011514)2.40328889
50Diplopia (HP:0000651)2.40328889
51Limb dystonia (HP:0002451)2.39906700
52Papilledema (HP:0001085)2.36945894
53Tetraplegia (HP:0002445)2.35892059
54Akinesia (HP:0002304)2.31769670
55Spastic gait (HP:0002064)2.30126403
56Pheochromocytoma (HP:0002666)2.27497014
57Megalencephaly (HP:0001355)2.27336013
58Bradykinesia (HP:0002067)2.26900272
59Urinary urgency (HP:0000012)2.26093457
60Abnormality of ocular smooth pursuit (HP:0000617)2.23713635
61Polyphagia (HP:0002591)2.23060800
62Spastic tetraparesis (HP:0001285)2.22408893
63Fetal akinesia sequence (HP:0001989)2.21735097
64Status epilepticus (HP:0002133)2.18373456
65Torticollis (HP:0000473)2.17200403
66Cerebral inclusion bodies (HP:0100314)2.16695617
67Blue irides (HP:0000635)2.16049467
68Morphological abnormality of the pyramidal tract (HP:0002062)2.15746649
69Insidious onset (HP:0003587)2.15542192
70Termporal pattern (HP:0011008)2.15542192
71Intention tremor (HP:0002080)2.15250668
72Gait imbalance (HP:0002141)2.15152658
73Abnormality of salivation (HP:0100755)2.10780318
74Neurofibrillary tangles (HP:0002185)2.09556260
75Dysmetric saccades (HP:0000641)2.07858755
76Hemiplegia (HP:0002301)2.04086935
77Spastic tetraplegia (HP:0002510)2.03941913
78Abnormality of the corticospinal tract (HP:0002492)2.02845071
79Agitation (HP:0000713)2.02136634
80Gait ataxia (HP:0002066)2.01534737
81Lower limb muscle weakness (HP:0007340)2.01422957
82Impaired vibratory sensation (HP:0002495)2.00822661
83Generalized myoclonic seizures (HP:0002123)2.00416434
84Postural tremor (HP:0002174)1.99895443
85Clonus (HP:0002169)1.99476704
86Prolonged QT interval (HP:0001657)1.99350407
87Dyskinesia (HP:0100660)1.97568845
88Focal dystonia (HP:0004373)1.97529252
89Abnormality of the lower motor neuron (HP:0002366)1.97324600
90Neuroendocrine neoplasm (HP:0100634)1.95468018
91Aplasia involving bones of the extremities (HP:0009825)1.94078562
92Aplasia involving bones of the upper limbs (HP:0009823)1.94078562
93Aplasia of the phalanges of the hand (HP:0009802)1.94078562
94Central scotoma (HP:0000603)1.93610117
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93046414
96Degeneration of the lateral corticospinal tracts (HP:0002314)1.93046414
97Abnormality of macular pigmentation (HP:0008002)1.92974688
98Increased circulating renin level (HP:0000848)1.92673611
99Annular pancreas (HP:0001734)1.92594266
100Incomplete penetrance (HP:0003829)1.90729450
101Generalized hypopigmentation of hair (HP:0011358)1.88841262
102Specific learning disability (HP:0001328)1.88594061
103Muscular hypotonia of the trunk (HP:0008936)1.88585327
104Exotropia (HP:0000577)1.87658238
105Congenital stationary night blindness (HP:0007642)1.86076359
106Ventricular fibrillation (HP:0001663)1.85777184
107Retinal dysplasia (HP:0007973)1.85574113
108Hyperthyroidism (HP:0000836)1.85502495
109Rigidity (HP:0002063)1.83769262
110Obstructive sleep apnea (HP:0002870)1.78706752
111Amyotrophic lateral sclerosis (HP:0007354)1.77691422
112Psychosis (HP:0000709)1.75738957
113Abnormal EKG (HP:0003115)1.75137288
114Syncope (HP:0001279)1.74719229
115Congenital primary aphakia (HP:0007707)1.74518413
116Bundle branch block (HP:0011710)1.73828888
117Clumsiness (HP:0002312)1.72669498
118Craniofacial dystonia (HP:0012179)1.72605033
119Medial flaring of the eyebrow (HP:0010747)1.72407328
120Hypoventilation (HP:0002791)1.71287764
121Inappropriate behavior (HP:0000719)1.70984122
122Poor suck (HP:0002033)1.70125328
123Abnormality of the labia minora (HP:0012880)1.68098928
124Esotropia (HP:0000565)1.67228345
125CNS hypomyelination (HP:0003429)1.66271454
126Heterochromia iridis (HP:0001100)1.64790382
127Neuronal loss in central nervous system (HP:0002529)1.64604606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.59916125
2EPHA44.03252548
3MAP3K93.47425405
4CASK3.29438058
5MAP3K43.00677346
6MARK12.98680358
7MAP2K72.66622797
8MINK12.51660689
9DAPK22.51593770
10MAP3K122.28112747
11FRK2.23839650
12PAK62.11823668
13TNIK2.10919364
14NTRK21.94856051
15RIPK41.92115193
16KSR21.88962832
17MAP2K41.86826487
18NTRK11.72168088
19PRPF4B1.67950087
20CDK191.61375980
21DAPK11.59598987
22KSR11.58701737
23PLK21.55247450
24PRKD31.55083011
25GRK51.48868609
26CDK51.48174066
27MAPK131.48069887
28SIK21.47056128
29CAMKK11.47004949
30FGFR21.30523223
31CAMKK21.24589830
32CCNB11.22708377
33PNCK1.21849080
34PRKCG1.21241414
35PHKG11.19844487
36PHKG21.19844487
37STK381.19005480
38ARAF1.13298981
39SGK21.08561603
40SGK2231.07148711
41SGK4941.07148711
42CAMK2A1.06821476
43MAP3K131.03544357
44MAP3K21.00397603
45FES0.97073575
46ERBB30.92977186
47DYRK1A0.92347773
48UHMK10.91100481
49BRSK10.89731734
50OXSR10.87576953
51CDK180.86755667
52CAMK2B0.84541871
53CDK150.84311634
54CDK140.83960077
55BMPR20.83410801
56CSNK1G30.82901252
57CAMK10.81486273
58STK110.79770952
59SGK30.79210870
60PAK30.75220789
61CDK11A0.73925971
62SGK10.73250463
63PTK2B0.71879703
64RAF10.70364914
65PKN10.69185676
66LATS20.68062630
67TRIM280.67944899
68PINK10.67700345
69MAP4K20.67436854
70CSNK1G20.66980513
71RET0.66914256
72TYRO30.66784784
73CSNK1G10.66608429
74MAPKAPK50.66530806
75TAOK10.66412613
76PRKCH0.66077600
77WNK30.65043506
78CSNK1A1L0.64983347
79PRKCE0.63212791
80LMTK20.62329841
81MARK20.60675769
82AKT30.60089689
83PDK10.59610156
84TNK20.59277832
85LIMK10.58850122
86MUSK0.58453160
87CAMK2D0.57296593
88PDPK10.55500048
89WNK40.54070964
90ADRBK20.52916533
91CAMK1G0.51856660
92DYRK20.51643365
93MAP3K10.51389508
94CDK30.49887376
95SIK30.49025624
96PRKCZ0.48542633
97FGR0.48192040
98CSNK1D0.47003984
99MAPK120.46693452
100CAMK2G0.46058604
101RPS6KA30.44835802
102PRKG10.44300703
103FER0.44003034
104NME10.42880490
105WNK10.42671951
106CDC42BPA0.41626594
107MAP2K10.41498015
108* PRKCA0.40747420
109CSNK1A10.40641817
110IRAK20.39454012
111MAPK100.37891700
112NEK60.37226694
113ALK0.36864395
114CSNK1E0.35986983
115FYN0.35731436
116MAP3K70.35442243
117MAP3K60.35048250
118TAOK20.33921731
119ADRBK10.33865958
120BMPR1B0.33784243
121GRK10.33673033
122INSRR0.33420019
123GRK70.33184305
124BCR0.32589391
125CAMK40.32520117
126PRKACA0.31545571

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.94433620
2Synaptic vesicle cycle_Homo sapiens_hsa047213.30451963
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81969751
4Circadian entrainment_Homo sapiens_hsa047132.75817563
5GABAergic synapse_Homo sapiens_hsa047272.71707954
6Olfactory transduction_Homo sapiens_hsa047402.68302503
7Glutamatergic synapse_Homo sapiens_hsa047242.64715658
8Long-term potentiation_Homo sapiens_hsa047202.64518235
9Morphine addiction_Homo sapiens_hsa050322.60351559
10Amphetamine addiction_Homo sapiens_hsa050312.46563125
11Insulin secretion_Homo sapiens_hsa049112.20203976
12Salivary secretion_Homo sapiens_hsa049702.18351254
13Dopaminergic synapse_Homo sapiens_hsa047282.16396841
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10823176
15Taste transduction_Homo sapiens_hsa047421.94857894
16Cholinergic synapse_Homo sapiens_hsa047251.91734604
17Serotonergic synapse_Homo sapiens_hsa047261.84765012
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80443633
19Renin secretion_Homo sapiens_hsa049241.79995579
20Gastric acid secretion_Homo sapiens_hsa049711.77776219
21Long-term depression_Homo sapiens_hsa047301.74137454
22Cocaine addiction_Homo sapiens_hsa050301.66749476
23Oxytocin signaling pathway_Homo sapiens_hsa049211.65029049
24Calcium signaling pathway_Homo sapiens_hsa040201.60731282
25Vitamin B6 metabolism_Homo sapiens_hsa007501.58114280
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57485447
27Collecting duct acid secretion_Homo sapiens_hsa049661.52608375
28GnRH signaling pathway_Homo sapiens_hsa049121.40917683
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36039842
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32685114
31Gap junction_Homo sapiens_hsa045401.28337664
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28301591
33cAMP signaling pathway_Homo sapiens_hsa040241.24753430
34Phototransduction_Homo sapiens_hsa047441.19296669
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19211386
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19061628
37Type II diabetes mellitus_Homo sapiens_hsa049301.16472061
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15296369
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14584217
40Estrogen signaling pathway_Homo sapiens_hsa049151.09317223
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06844833
42Axon guidance_Homo sapiens_hsa043601.06555632
43Cardiac muscle contraction_Homo sapiens_hsa042601.06156904
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05370835
45Glioma_Homo sapiens_hsa052141.04396260
46ErbB signaling pathway_Homo sapiens_hsa040121.01113132
47Melanogenesis_Homo sapiens_hsa049160.99618331
48Vibrio cholerae infection_Homo sapiens_hsa051100.94342301
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.92307714
50Circadian rhythm_Homo sapiens_hsa047100.90047832
51Pancreatic secretion_Homo sapiens_hsa049720.88045781
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87990371
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81983789
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79389228
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.78496555
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.76570715
57Dorso-ventral axis formation_Homo sapiens_hsa043200.76551497
58Thyroid hormone synthesis_Homo sapiens_hsa049180.73247226
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72847552
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72829041
61MAPK signaling pathway_Homo sapiens_hsa040100.71269886
62Dilated cardiomyopathy_Homo sapiens_hsa054140.71061507
63Choline metabolism in cancer_Homo sapiens_hsa052310.70877158
64Oocyte meiosis_Homo sapiens_hsa041140.69239861
65Regulation of autophagy_Homo sapiens_hsa041400.69162880
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66277439
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65046225
68Glucagon signaling pathway_Homo sapiens_hsa049220.64309851
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61241988
70Butanoate metabolism_Homo sapiens_hsa006500.60723185
71Ras signaling pathway_Homo sapiens_hsa040140.58819718
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56813712
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55727005
74Alzheimers disease_Homo sapiens_hsa050100.54495364
75Inositol phosphate metabolism_Homo sapiens_hsa005620.53127025
76Nitrogen metabolism_Homo sapiens_hsa009100.52041562
77VEGF signaling pathway_Homo sapiens_hsa043700.51991882
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.50774538
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49898721
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.49246217
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48721612
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47562130
83Rap1 signaling pathway_Homo sapiens_hsa040150.47363396
84mTOR signaling pathway_Homo sapiens_hsa041500.46822941
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46150316
86Alcoholism_Homo sapiens_hsa050340.45682081
87African trypanosomiasis_Homo sapiens_hsa051430.44530311
88Wnt signaling pathway_Homo sapiens_hsa043100.43357203
89ABC transporters_Homo sapiens_hsa020100.42487965
90Insulin signaling pathway_Homo sapiens_hsa049100.41749261
91Arginine biosynthesis_Homo sapiens_hsa002200.41676237
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41363837
93Type I diabetes mellitus_Homo sapiens_hsa049400.40769317
94Endometrial cancer_Homo sapiens_hsa052130.38353218
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38102406
96Ether lipid metabolism_Homo sapiens_hsa005650.37224288
97Ovarian steroidogenesis_Homo sapiens_hsa049130.36827642
98Mineral absorption_Homo sapiens_hsa049780.36148200
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35279539
100Bile secretion_Homo sapiens_hsa049760.35169668
101Endocytosis_Homo sapiens_hsa041440.34031661
102Fatty acid biosynthesis_Homo sapiens_hsa000610.33227062
103Oxidative phosphorylation_Homo sapiens_hsa001900.32631541
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32435829
105Prion diseases_Homo sapiens_hsa050200.31648372
106Renal cell carcinoma_Homo sapiens_hsa052110.31429148
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30339725
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29996108
109Tight junction_Homo sapiens_hsa045300.28039693
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27927367
111beta-Alanine metabolism_Homo sapiens_hsa004100.27277217
112Non-small cell lung cancer_Homo sapiens_hsa052230.25989934
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.25300993
114AMPK signaling pathway_Homo sapiens_hsa041520.24699690
115Chemokine signaling pathway_Homo sapiens_hsa040620.23680018
116Parkinsons disease_Homo sapiens_hsa050120.23599402
117Folate biosynthesis_Homo sapiens_hsa007900.21492492

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »