RGS7BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.78753551
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.55271255
3vocalization behavior (GO:0071625)5.44119796
4neuronal action potential propagation (GO:0019227)5.34925351
5synaptic vesicle exocytosis (GO:0016079)5.34810102
6locomotory exploration behavior (GO:0035641)5.28540416
7synaptic vesicle maturation (GO:0016188)5.24406400
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.13918909
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.10978092
10glutamate secretion (GO:0014047)4.97371832
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.87815490
12regulation of glutamate receptor signaling pathway (GO:1900449)4.75852094
13protein localization to synapse (GO:0035418)4.72578059
14regulation of synaptic vesicle exocytosis (GO:2000300)4.71903784
15postsynaptic membrane organization (GO:0001941)4.59543161
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.50106359
17glutamate receptor signaling pathway (GO:0007215)4.44108268
18neuron cell-cell adhesion (GO:0007158)4.38686453
19neurotransmitter secretion (GO:0007269)4.35129756
20regulation of neuronal synaptic plasticity (GO:0048168)4.35041588
21synaptic transmission, glutamatergic (GO:0035249)4.29348905
22neuron-neuron synaptic transmission (GO:0007270)4.25236560
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.23451796
24regulation of synaptic vesicle transport (GO:1902803)4.23121923
25regulation of synapse structural plasticity (GO:0051823)4.22552640
26exploration behavior (GO:0035640)4.21560914
27gamma-aminobutyric acid transport (GO:0015812)4.15622992
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.12990383
29L-amino acid import (GO:0043092)4.09537991
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.08064754
31regulation of excitatory postsynaptic membrane potential (GO:0060079)3.97957343
32neurotransmitter-gated ion channel clustering (GO:0072578)3.90722564
33cellular sodium ion homeostasis (GO:0006883)3.88440677
34long-term memory (GO:0007616)3.86324434
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.86252518
36regulation of synapse maturation (GO:0090128)3.85595775
37amino acid import (GO:0043090)3.83321001
38cellular potassium ion homeostasis (GO:0030007)3.82297931
39layer formation in cerebral cortex (GO:0021819)3.80126934
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.77910558
41regulation of postsynaptic membrane potential (GO:0060078)3.75351592
42positive regulation of membrane potential (GO:0045838)3.74787804
43transmission of nerve impulse (GO:0019226)3.68652971
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.65466435
45regulation of dendritic spine morphogenesis (GO:0061001)3.65216114
46potassium ion homeostasis (GO:0055075)3.65180864
47regulation of synaptic plasticity (GO:0048167)3.64939901
48positive regulation of synapse maturation (GO:0090129)3.60745746
49dendritic spine morphogenesis (GO:0060997)3.60472929
50cerebellar Purkinje cell differentiation (GO:0021702)3.57512723
51cell communication by electrical coupling (GO:0010644)3.56601518
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.56439364
53potassium ion import (GO:0010107)3.53315423
54neurotransmitter transport (GO:0006836)3.52150804
55long-term synaptic potentiation (GO:0060291)3.50767469
56neuromuscular process controlling balance (GO:0050885)3.48118607
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.46150961
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.45182506
59neuron recognition (GO:0008038)3.45141071
60membrane depolarization during action potential (GO:0086010)3.42891188
61establishment of mitochondrion localization (GO:0051654)3.40582908
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.40420513
63prepulse inhibition (GO:0060134)3.40139167
64proline transport (GO:0015824)3.38153120
65regulation of neuron projection regeneration (GO:0070570)3.37604306
66regulation of axon regeneration (GO:0048679)3.37604306
67membrane depolarization (GO:0051899)3.36861569
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.36283866
69regulation of neurotransmitter secretion (GO:0046928)3.33455834
70regulation of neurotransmitter levels (GO:0001505)3.31029406
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28815091
72sodium ion export (GO:0071436)3.28216407
73activation of protein kinase A activity (GO:0034199)3.27273191
74regulation of vesicle fusion (GO:0031338)3.27210963
75neuromuscular process controlling posture (GO:0050884)3.26686116
76acidic amino acid transport (GO:0015800)3.22725327
77behavioral response to cocaine (GO:0048148)3.20983871
78synaptic vesicle endocytosis (GO:0048488)3.20194561
79membrane hyperpolarization (GO:0060081)3.19725042
80auditory behavior (GO:0031223)3.17885284
81striatum development (GO:0021756)3.17285507
82negative regulation of dendrite morphogenesis (GO:0050774)3.15938813
83positive regulation of dendritic spine development (GO:0060999)3.15563211
84behavioral fear response (GO:0001662)3.15206791
85behavioral defense response (GO:0002209)3.15206791
86response to auditory stimulus (GO:0010996)3.14119440
87serotonin metabolic process (GO:0042428)3.13626584
88regulation of neurotransmitter transport (GO:0051588)3.13552333
89learning (GO:0007612)3.13526667
90G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.12120393
91response to histamine (GO:0034776)3.11787583
92startle response (GO:0001964)3.11576863
93regulation of dendritic spine development (GO:0060998)3.11280422
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10579656
95long term synaptic depression (GO:0060292)3.10379949
96positive regulation of neurotransmitter transport (GO:0051590)3.10323001
97positive regulation of neurotransmitter secretion (GO:0001956)3.10082304
98regulation of voltage-gated calcium channel activity (GO:1901385)3.09446667
99presynaptic membrane assembly (GO:0097105)3.08798523
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08748183
101cell communication involved in cardiac conduction (GO:0086065)3.08410359
102neuronal ion channel clustering (GO:0045161)3.06275002
103establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.06084311
104mitochondrion transport along microtubule (GO:0047497)3.06084311
105synapse assembly (GO:0007416)3.05967317
106synaptic transmission (GO:0007268)3.05966661
107mating behavior (GO:0007617)3.05922282
108adult walking behavior (GO:0007628)3.04851771
109neuromuscular synaptic transmission (GO:0007274)3.04590554
110axonal fasciculation (GO:0007413)3.03042564
111detection of calcium ion (GO:0005513)3.02885171
112neurotransmitter uptake (GO:0001504)3.02585279
113central nervous system myelination (GO:0022010)3.01540674
114axon ensheathment in central nervous system (GO:0032291)3.01540674
115neuromuscular process (GO:0050905)3.01523167
116positive regulation of potassium ion transmembrane transport (GO:1901381)3.01500391
117negative regulation of dendrite development (GO:2000171)3.01115963
118cerebellar granule cell differentiation (GO:0021707)3.00543536
119regulation of synaptic transmission (GO:0050804)2.99435500
120fear response (GO:0042596)2.99188797
121presynaptic membrane organization (GO:0097090)2.96821495
122glycine transport (GO:0015816)2.96459959
123positive regulation of synaptic transmission (GO:0050806)2.96300382
124synaptic transmission, dopaminergic (GO:0001963)2.95021435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.10808040
2GBX2_23144817_ChIP-Seq_PC3_Human3.73230339
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23791124
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16660044
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14379967
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77880698
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77880698
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69245871
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68574039
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.65676336
11REST_21632747_ChIP-Seq_MESCs_Mouse2.65585367
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57646598
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56888206
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54829527
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50440599
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.48409900
17DROSHA_22980978_ChIP-Seq_HELA_Human2.40925008
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.32888084
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21002514
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.20701764
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.16906907
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.13506884
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07775602
24TAF15_26573619_Chip-Seq_HEK293_Human2.03681195
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03530727
26AR_21572438_ChIP-Seq_LNCaP_Human1.98027987
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91554618
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83341257
29SMAD4_21799915_ChIP-Seq_A2780_Human1.74325201
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73719470
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68253201
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65228782
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64859407
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63093274
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60083231
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56666390
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53278671
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.51370642
39* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50652869
40P300_19829295_ChIP-Seq_ESCs_Human1.46946993
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.41082042
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38760718
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37850320
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37132782
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.35595465
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.32615816
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.31564427
48ZNF274_21170338_ChIP-Seq_K562_Hela1.30801864
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30557595
50AR_25329375_ChIP-Seq_VCAP_Human1.29978549
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29663595
52STAT3_23295773_ChIP-Seq_U87_Human1.28100964
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27988420
54* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27009859
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26982294
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.26194521
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25793921
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.23390289
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22505470
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.22256891
61AR_19668381_ChIP-Seq_PC3_Human1.19177020
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18086535
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17793342
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15789347
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15425745
66IGF1R_20145208_ChIP-Seq_DFB_Human1.14711147
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13283534
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11023126
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10772056
70* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10660992
71LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10499087
72VDR_22108803_ChIP-Seq_LS180_Human1.10073492
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09807281
74* TCF4_23295773_ChIP-Seq_U87_Human1.09623242
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08620287
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07604817
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06626755
78* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06349717
79GATA1_26923725_Chip-Seq_HPCs_Mouse1.06316020
80RNF2_27304074_Chip-Seq_NSC_Mouse1.04996245
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.04983146
82CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04789615
83* RING1B_27294783_Chip-Seq_NPCs_Mouse1.04492728
84TP53_16413492_ChIP-PET_HCT116_Human1.04335183
85SOX9_26525672_Chip-Seq_HEART_Mouse1.04176659
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.03317407
87AHR_22903824_ChIP-Seq_MCF-7_Human1.02735257
88* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02705951
89RUNX2_22187159_ChIP-Seq_PCA_Human1.02131506
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01915286
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01827820
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01172867
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01172867
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01065320
95BCAT_22108803_ChIP-Seq_LS180_Human0.99373381
96FUS_26573619_Chip-Seq_HEK293_Human0.97597504
97KDM2B_26808549_Chip-Seq_REH_Human0.96527663
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95060554
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94569888
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.93917846
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93876032
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93299132
103JUN_21703547_ChIP-Seq_K562_Human0.92954129
104SMAD3_21741376_ChIP-Seq_ESCs_Human0.92914676
105TP53_18474530_ChIP-ChIP_U2OS_Human0.90294692
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.89979969
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89567954
108KDM2B_26808549_Chip-Seq_K562_Human0.88975563
109RXR_22108803_ChIP-Seq_LS180_Human0.88645068
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88291721
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86328624
112NANOG_18555785_Chip-Seq_ESCs_Mouse0.86310582
113SMAD4_21741376_ChIP-Seq_EPCs_Human0.85420034
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85096023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.42243786
2MP0003880_abnormal_central_pattern4.83986689
3MP0003635_abnormal_synaptic_transmissio4.20572848
4MP0004270_analgesia3.78916826
5MP0009745_abnormal_behavioral_response3.58006168
6MP0002822_catalepsy3.48209058
7MP0001968_abnormal_touch/_nociception3.46540484
8MP0009046_muscle_twitch3.42668625
9MP0002063_abnormal_learning/memory/cond3.34270041
10MP0002064_seizures3.26065620
11MP0002272_abnormal_nervous_system2.84573093
12MP0002572_abnormal_emotion/affect_behav2.83953492
13MP0002735_abnormal_chemical_nociception2.78152786
14MP0002736_abnormal_nociception_after2.77119504
15MP0002734_abnormal_mechanical_nocicepti2.74906587
16MP0001486_abnormal_startle_reflex2.61864559
17MP0005423_abnormal_somatic_nervous2.39728066
18MP0001501_abnormal_sleep_pattern2.36028031
19MP0002733_abnormal_thermal_nociception2.28180943
20MP0001440_abnormal_grooming_behavior2.17964022
21MP0001970_abnormal_pain_threshold2.15438975
22MP0002067_abnormal_sensory_capabilities2.12132835
23MP0008569_lethality_at_weaning2.02772257
24MP0003329_amyloid_beta_deposits1.94549044
25MP0002184_abnormal_innervation1.84167210
26MP0005386_behavior/neurological_phenoty1.76786399
27MP0004924_abnormal_behavior1.76786399
28MP0004858_abnormal_nervous_system1.73897909
29MP0006276_abnormal_autonomic_nervous1.71966668
30MP0002557_abnormal_social/conspecific_i1.70243736
31MP0004811_abnormal_neuron_physiology1.68023184
32MP0002909_abnormal_adrenal_gland1.67697981
33MP0001984_abnormal_olfaction1.64627150
34MP0009780_abnormal_chondrocyte_physiolo1.62907531
35MP0000778_abnormal_nervous_system1.58480487
36MP0000955_abnormal_spinal_cord1.53404593
37MP0003879_abnormal_hair_cell1.50430369
38MP0005646_abnormal_pituitary_gland1.50236496
39MP0001529_abnormal_vocalization1.43574758
40MP0002066_abnormal_motor_capabilities/c1.42564684
41MP0001188_hyperpigmentation1.38912246
42MP0003633_abnormal_nervous_system1.36152985
43MP0002882_abnormal_neuron_morphology1.35821571
44MP0004142_abnormal_muscle_tone1.25067164
45MP0004885_abnormal_endolymph1.24851121
46MP0001905_abnormal_dopamine_level1.23114898
47MP0003631_nervous_system_phenotype1.17508207
48MP0001502_abnormal_circadian_rhythm1.16237068
49MP0004145_abnormal_muscle_electrophysio1.14954585
50MP0004147_increased_porphyrin_level1.10006855
51MP0008872_abnormal_physiological_respon1.09145557
52MP0008874_decreased_physiological_sensi1.06233528
53MP0002837_dystrophic_cardiac_calcinosis1.05104225
54MP0003787_abnormal_imprinting1.04897317
55MP0005409_darkened_coat_color1.02303435
56MP0002152_abnormal_brain_morphology0.99868014
57MP0002229_neurodegeneration0.99680505
58MP0004742_abnormal_vestibular_system0.97305169
59MP0000013_abnormal_adipose_tissue0.95919974
60MP0005645_abnormal_hypothalamus_physiol0.95552265
61MP0000751_myopathy0.94678929
62MP0000920_abnormal_myelination0.92975263
63MP0004085_abnormal_heartbeat0.90668548
64MP0000604_amyloidosis0.90083179
65MP0002069_abnormal_eating/drinking_beha0.87497826
66MP0005535_abnormal_body_temperature0.87373814
67MP0001177_atelectasis0.86555523
68MP0003632_abnormal_nervous_system0.85566084
69MP0005551_abnormal_eye_electrophysiolog0.83027662
70MP0003121_genomic_imprinting0.82412664
71MP0004215_abnormal_myocardial_fiber0.82382367
72MP0003634_abnormal_glial_cell0.82001914
73MP0001963_abnormal_hearing_physiology0.81823721
74MP0004484_altered_response_of0.81105111
75MP0003878_abnormal_ear_physiology0.79862968
76MP0005377_hearing/vestibular/ear_phenot0.79862968
77MP0010386_abnormal_urinary_bladder0.79678783
78MP0005187_abnormal_penis_morphology0.79478779
79MP0003075_altered_response_to0.79108237
80MP0003690_abnormal_glial_cell0.78322270
81MP0002102_abnormal_ear_morphology0.77852274
82MP0008877_abnormal_DNA_methylation0.73769764
83MP0002752_abnormal_somatic_nervous0.72268045
84MP0001485_abnormal_pinna_reflex0.72235635
85MP0003123_paternal_imprinting0.71552007
86MP0001986_abnormal_taste_sensitivity0.70199194
87MP0002090_abnormal_vision0.68914816
88MP0000026_abnormal_inner_ear0.68056775
89MP0003122_maternal_imprinting0.67953049
90MP0003137_abnormal_impulse_conducting0.65728397
91MP0005499_abnormal_olfactory_system0.65623045
92MP0005394_taste/olfaction_phenotype0.65623045
93MP0004133_heterotaxia0.64652111
94MP0000569_abnormal_digit_pigmentation0.64234744
95MP0001664_abnormal_digestion0.63143524
96MP0005167_abnormal_blood-brain_barrier0.62041090
97MP0002876_abnormal_thyroid_physiology0.61885295
98MP0003861_abnormal_nervous_system0.61383613
99MP0010768_mortality/aging0.59578607
100MP0002082_postnatal_lethality0.59496979
101MP0008961_abnormal_basal_metabolism0.59462873
102MP0004510_myositis0.59318229
103MP0000631_abnormal_neuroendocrine_gland0.56623453
104MP0002638_abnormal_pupillary_reflex0.56332037
105MP0005171_absent_coat_pigmentation0.54511359
106MP0001943_abnormal_respiration0.53265904
107MP0000579_abnormal_nail_morphology0.52796083
108MP0004043_abnormal_pH_regulation0.50935534
109MP0003283_abnormal_digestive_organ0.50746939
110MP0000639_abnormal_adrenal_gland0.50086733
111MP0010234_abnormal_vibrissa_follicle0.49267506
112MP0010769_abnormal_survival0.48677803
113MP0001299_abnormal_eye_distance/0.48385861
114MP0003956_abnormal_body_size0.47854856
115MP0010770_preweaning_lethality0.47267728
116MP0001348_abnormal_lacrimal_gland0.46507886
117MP0005253_abnormal_eye_physiology0.45960113

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.89607551
2Myokymia (HP:0002411)7.38367174
3Focal seizures (HP:0007359)6.24543951
4Atonic seizures (HP:0010819)5.29434692
5Visual hallucinations (HP:0002367)5.13152948
6Epileptic encephalopathy (HP:0200134)5.03828298
7Febrile seizures (HP:0002373)5.02475858
8Progressive cerebellar ataxia (HP:0002073)4.58985110
9Absence seizures (HP:0002121)4.53725480
10Action tremor (HP:0002345)4.48588721
11Dialeptic seizures (HP:0011146)4.21971137
12Generalized tonic-clonic seizures (HP:0002069)4.07543699
13Gaze-evoked nystagmus (HP:0000640)3.86710607
14Broad-based gait (HP:0002136)3.72288668
15Hyperventilation (HP:0002883)3.70381078
16Poor eye contact (HP:0000817)3.63461000
17Dysdiadochokinesis (HP:0002075)3.51568867
18Supranuclear gaze palsy (HP:0000605)3.43966174
19Truncal ataxia (HP:0002078)3.35585162
20Impaired social interactions (HP:0000735)3.34299200
21Abnormal social behavior (HP:0012433)3.34299200
22Dysmetria (HP:0001310)3.31651598
23Impaired vibration sensation in the lower limbs (HP:0002166)3.25393557
24Scanning speech (HP:0002168)3.20496510
25Depression (HP:0000716)3.12860573
26Ankle clonus (HP:0011448)3.11595011
27Anxiety (HP:0000739)3.08639121
28Amblyopia (HP:0000646)3.08416259
29Urinary bladder sphincter dysfunction (HP:0002839)3.01790301
30Impaired smooth pursuit (HP:0007772)2.83652948
31Abnormal eating behavior (HP:0100738)2.82894327
32Septo-optic dysplasia (HP:0100842)2.80927292
33Progressive inability to walk (HP:0002505)2.75853484
34Termporal pattern (HP:0011008)2.73235011
35Insidious onset (HP:0003587)2.73235011
36Postural instability (HP:0002172)2.71238389
37Hemiparesis (HP:0001269)2.67233555
38Urinary urgency (HP:0000012)2.64178828
39Dysmetric saccades (HP:0000641)2.63096630
40Sleep apnea (HP:0010535)2.62624603
41Neurofibrillary tangles (HP:0002185)2.61202269
42Annular pancreas (HP:0001734)2.58985694
43Cerebral inclusion bodies (HP:0100314)2.56369510
44Genetic anticipation (HP:0003743)2.55098331
45Stereotypic behavior (HP:0000733)2.54530098
46Intention tremor (HP:0002080)2.54353582
47Papilledema (HP:0001085)2.53250732
48Status epilepticus (HP:0002133)2.52513721
49Spastic gait (HP:0002064)2.52271816
50Abnormality of binocular vision (HP:0011514)2.51019257
51Diplopia (HP:0000651)2.51019257
52Torticollis (HP:0000473)2.50749964
53Gait imbalance (HP:0002141)2.50614204
54Excessive salivation (HP:0003781)2.50593363
55Drooling (HP:0002307)2.50593363
56Epileptiform EEG discharges (HP:0011182)2.50474378
57Mutism (HP:0002300)2.49826378
58Obstructive sleep apnea (HP:0002870)2.48071233
59Absent speech (HP:0001344)2.47474830
60Cerebral hypomyelination (HP:0006808)2.46001753
61Aplasia involving bones of the extremities (HP:0009825)2.45487289
62Aplasia involving bones of the upper limbs (HP:0009823)2.45487289
63Aplasia of the phalanges of the hand (HP:0009802)2.45487289
64Hemiplegia (HP:0002301)2.41707345
65Abnormality of ocular smooth pursuit (HP:0000617)2.39988942
66Focal dystonia (HP:0004373)2.39298994
67Inability to walk (HP:0002540)2.38747613
68EEG with generalized epileptiform discharges (HP:0011198)2.36509044
69Fetal akinesia sequence (HP:0001989)2.35323331
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.35158902
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.35158902
72Akinesia (HP:0002304)2.35141402
73Pheochromocytoma (HP:0002666)2.34734696
74Bradykinesia (HP:0002067)2.32587672
75Impaired vibratory sensation (HP:0002495)2.27875363
76Abnormality of the lower motor neuron (HP:0002366)2.26801989
77Optic nerve hypoplasia (HP:0000609)2.25138603
78Abnormality of the corticospinal tract (HP:0002492)2.22102509
79Hypsarrhythmia (HP:0002521)2.21607123
80Ventricular fibrillation (HP:0001663)2.20141344
81Generalized myoclonic seizures (HP:0002123)2.18771552
82Alacrima (HP:0000522)2.14411654
83Tetraplegia (HP:0002445)2.14303996
84Megalencephaly (HP:0001355)2.13416160
85Resting tremor (HP:0002322)2.11452625
86Gait ataxia (HP:0002066)2.09986772
87Craniofacial dystonia (HP:0012179)2.08477385
88Morphological abnormality of the pyramidal tract (HP:0002062)2.06144139
89Limb dystonia (HP:0002451)2.06026433
90Neuroendocrine neoplasm (HP:0100634)2.05375155
91Lower limb muscle weakness (HP:0007340)2.02878611
92Lower limb asymmetry (HP:0100559)2.01491171
93Spastic tetraplegia (HP:0002510)2.00021269
94Incomplete penetrance (HP:0003829)1.99014443
95Blue irides (HP:0000635)1.96786509
96CNS hypomyelination (HP:0003429)1.91661675
97Peripheral hypomyelination (HP:0007182)1.90979625
98Pointed chin (HP:0000307)1.89240866
99Neuronal loss in central nervous system (HP:0002529)1.88098187
100Abnormality of saccadic eye movements (HP:0000570)1.86833937
101Specific learning disability (HP:0001328)1.85644938
102Congenital primary aphakia (HP:0007707)1.85601625
103Apathy (HP:0000741)1.84313243
104Psychosis (HP:0000709)1.84262792
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83011534
106Lower limb amyotrophy (HP:0007210)1.81150190
107Delusions (HP:0000746)1.80563293
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80470704
109Retinal dysplasia (HP:0007973)1.79404756
110Decreased lacrimation (HP:0000633)1.76828843
111Amyotrophic lateral sclerosis (HP:0007354)1.75603906
112Hypoplasia of the corpus callosum (HP:0002079)1.75102677
113Ulnar claw (HP:0001178)1.75065519
114Abnormality of salivation (HP:0100755)1.73908651
115Ankyloglossia (HP:0010296)1.72570517
116Clonus (HP:0002169)1.72414468
117Rapidly progressive (HP:0003678)1.72317444
118Protruding tongue (HP:0010808)1.71936643
119Abnormal EKG (HP:0003115)1.71495377
120Neoplasm of the peripheral nervous system (HP:0100007)1.70262459
121Polyphagia (HP:0002591)1.70149434
122Postural tremor (HP:0002174)1.69310959
123Rigidity (HP:0002063)1.68986353
124Agitation (HP:0000713)1.67953232
125Bundle branch block (HP:0011710)1.67871948
126Nephrogenic diabetes insipidus (HP:0009806)1.67622102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.89693938
2NTRK34.62290318
3MAP3K93.76386828
4RIPK42.94110604
5MAP3K42.91831477
6MINK12.72465355
7MAP2K72.49732988
8KSR22.38362419
9DAPK22.36577994
10NTRK12.25558959
11PAK62.05193541
12MARK12.04356780
13MAP3K122.01683337
14CASK2.01678754
15MAP2K41.89395653
16CAMKK11.79380384
17NTRK21.78178528
18PRKD31.69070826
19PNCK1.67823534
20ARAF1.62352834
21TNIK1.59305656
22KSR11.55500134
23CDK51.54193556
24MAP3K131.53012417
25DAPK11.52910456
26FES1.49480713
27GRK51.45431368
28CAMKK21.45365089
29MAP3K21.36429886
30PLK21.35542000
31MAP4K21.34825488
32SIK21.31498757
33STK381.23080207
34PRKCG1.22139374
35PRPF4B1.20843577
36CDK191.19527161
37BMPR21.12329123
38MAPK131.08333311
39CAMK2A1.03941285
40WNK31.03937377
41RAF11.01680385
42PTK2B0.95449016
43SGK4940.94127899
44SGK2230.94127899
45CAMK2B0.89960705
46UHMK10.89592450
47CAMK10.88100646
48RET0.87549111
49PINK10.87093385
50CDK140.85425034
51CDK180.83964336
52TYRO30.83008385
53SGK20.82478273
54CDK150.81466334
55PKN10.81396507
56OXSR10.80707684
57LMTK20.79871141
58STK110.77768226
59PHKG10.75338709
60PHKG20.75338709
61LATS20.74811833
62SGK10.72196552
63WNK10.72193471
64TAOK10.71498616
65CDK11A0.70562848
66PRKCH0.69945868
67MAP3K10.69004967
68CSNK1A1L0.68235186
69PDK10.67593314
70PDPK10.66781518
71MAPK120.65632554
72TNK20.65102475
73SGK30.62102171
74PRKCE0.61599114
75DYRK20.61270411
76MARK20.60924264
77CSNK1G30.58953669
78CAMK2D0.58833003
79MAP2K10.58102711
80DYRK1A0.57646556
81FER0.57484566
82PAK30.55512066
83CSNK1G20.53638088
84CAMK2G0.52597090
85FGR0.50363323
86PRKCZ0.49098696
87NME10.48767985
88STK390.48054778
89NEK60.46861836
90FGFR20.46505606
91FYN0.46384359
92RPS6KA30.46176002
93LIMK10.46151712
94RIPK10.46048074
95SCYL20.45315075
96MAPK100.44942233
97CSNK1G10.44456080
98ALK0.42751570
99ROCK20.42079651
100PRKG10.40935217
101CAMK1G0.39670554
102PRKCA0.39386642
103BCR0.39150624
104CSNK1D0.38702217
105CCNB10.38521039
106MUSK0.38059314
107AKT30.36448203
108CDC42BPA0.36447364
109DMPK0.35317723
110MAP3K70.35004939
111PRKACA0.34810682
112CSNK1E0.34215906
113CAMK40.34102411
114PRKCB0.33955111
115SIK30.33564395
116GSK3B0.33222416
117BRAF0.33085954
118DAPK30.32535876
119CSNK1A10.32050585
120ERBB30.28006234

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.75586677
2Synaptic vesicle cycle_Homo sapiens_hsa047213.14483136
3Long-term potentiation_Homo sapiens_hsa047202.84066164
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.77942433
5GABAergic synapse_Homo sapiens_hsa047272.73848709
6Olfactory transduction_Homo sapiens_hsa047402.73470874
7Circadian entrainment_Homo sapiens_hsa047132.71041375
8Glutamatergic synapse_Homo sapiens_hsa047242.65948999
9Morphine addiction_Homo sapiens_hsa050322.58887117
10Amphetamine addiction_Homo sapiens_hsa050312.50992152
11Salivary secretion_Homo sapiens_hsa049702.28682725
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23659703
13Dopaminergic synapse_Homo sapiens_hsa047282.21705456
14Taste transduction_Homo sapiens_hsa047421.97412095
15Insulin secretion_Homo sapiens_hsa049111.94618332
16Cholinergic synapse_Homo sapiens_hsa047251.89799350
17Gastric acid secretion_Homo sapiens_hsa049711.89794194
18Long-term depression_Homo sapiens_hsa047301.84934395
19Renin secretion_Homo sapiens_hsa049241.82822676
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80622291
21Serotonergic synapse_Homo sapiens_hsa047261.73474300
22Oxytocin signaling pathway_Homo sapiens_hsa049211.69575370
23Calcium signaling pathway_Homo sapiens_hsa040201.69116077
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69094174
25Cocaine addiction_Homo sapiens_hsa050301.63022584
26Collecting duct acid secretion_Homo sapiens_hsa049661.50355933
27GnRH signaling pathway_Homo sapiens_hsa049121.43547638
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42289807
29Vitamin B6 metabolism_Homo sapiens_hsa007501.40439593
30Gap junction_Homo sapiens_hsa045401.36231375
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36147204
32cAMP signaling pathway_Homo sapiens_hsa040241.29915534
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29823121
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27062659
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22219504
36Cardiac muscle contraction_Homo sapiens_hsa042601.12979144
37Estrogen signaling pathway_Homo sapiens_hsa049151.12833215
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08973017
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08450552
40Glioma_Homo sapiens_hsa052141.05788777
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05095045
42Type II diabetes mellitus_Homo sapiens_hsa049301.05077238
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.01922389
44Melanogenesis_Homo sapiens_hsa049161.00377051
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99199242
46Axon guidance_Homo sapiens_hsa043600.97052936
47Pancreatic secretion_Homo sapiens_hsa049720.95941850
48ErbB signaling pathway_Homo sapiens_hsa040120.92365841
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91372278
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91201903
51Vibrio cholerae infection_Homo sapiens_hsa051100.88227270
52Phototransduction_Homo sapiens_hsa047440.86889544
53Dorso-ventral axis formation_Homo sapiens_hsa043200.86386757
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.86003283
55Oocyte meiosis_Homo sapiens_hsa041140.84779985
56Thyroid hormone synthesis_Homo sapiens_hsa049180.81055856
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79486965
58Choline metabolism in cancer_Homo sapiens_hsa052310.72575936
59Dilated cardiomyopathy_Homo sapiens_hsa054140.69138214
60Nitrogen metabolism_Homo sapiens_hsa009100.68229653
61MAPK signaling pathway_Homo sapiens_hsa040100.67705154
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67704307
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67045958
64Type I diabetes mellitus_Homo sapiens_hsa049400.65005693
65VEGF signaling pathway_Homo sapiens_hsa043700.63083762
66Alzheimers disease_Homo sapiens_hsa050100.62849596
67Rap1 signaling pathway_Homo sapiens_hsa040150.58353523
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56625463
69Ras signaling pathway_Homo sapiens_hsa040140.55646340
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.55152843
71African trypanosomiasis_Homo sapiens_hsa051430.55056256
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.54612049
73Glucagon signaling pathway_Homo sapiens_hsa049220.54431949
74Inositol phosphate metabolism_Homo sapiens_hsa005620.52238255
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51929086
76Fatty acid biosynthesis_Homo sapiens_hsa000610.50308106
77Alcoholism_Homo sapiens_hsa050340.47231255
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46463855
79Bile secretion_Homo sapiens_hsa049760.46276424
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45039627
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44356078
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42673620
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42604714
84Arginine biosynthesis_Homo sapiens_hsa002200.42106518
85Circadian rhythm_Homo sapiens_hsa047100.42094156
86Oxidative phosphorylation_Homo sapiens_hsa001900.40949579
87Endocytosis_Homo sapiens_hsa041440.40258568
88mTOR signaling pathway_Homo sapiens_hsa041500.40049220
89Butanoate metabolism_Homo sapiens_hsa006500.39904501
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39400042
91Non-small cell lung cancer_Homo sapiens_hsa052230.38734392
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37002204
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36020558
94Wnt signaling pathway_Homo sapiens_hsa043100.32602174
95Parkinsons disease_Homo sapiens_hsa050120.32420574
96Prion diseases_Homo sapiens_hsa050200.31591650
97Chemokine signaling pathway_Homo sapiens_hsa040620.31167427
98Insulin signaling pathway_Homo sapiens_hsa049100.30689255
99Mineral absorption_Homo sapiens_hsa049780.29959757
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29520631
101Hippo signaling pathway_Homo sapiens_hsa043900.29467211
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29193205
103Regulation of autophagy_Homo sapiens_hsa041400.28423139
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27849784
105Renal cell carcinoma_Homo sapiens_hsa052110.27620830
106AMPK signaling pathway_Homo sapiens_hsa041520.26794420
107Ovarian steroidogenesis_Homo sapiens_hsa049130.26736852
108Endometrial cancer_Homo sapiens_hsa052130.26693873
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26072120
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25865067
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24287553
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.24176696
113Tight junction_Homo sapiens_hsa045300.20914652
114Histidine metabolism_Homo sapiens_hsa003400.20875234
115beta-Alanine metabolism_Homo sapiens_hsa004100.20618136

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