RGS8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebellar granule cell differentiation (GO:0021707)6.76155996
2locomotory exploration behavior (GO:0035641)6.43304591
3response to pheromone (GO:0019236)6.30650597
4neuronal action potential propagation (GO:0019227)6.12521199
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.87713571
6cerebellar Purkinje cell differentiation (GO:0021702)5.71697528
7synaptic vesicle maturation (GO:0016188)5.67587900
8gamma-aminobutyric acid transport (GO:0015812)5.66476753
9regulation of short-term neuronal synaptic plasticity (GO:0048172)5.66253322
10cellular potassium ion homeostasis (GO:0030007)5.55167192
11ionotropic glutamate receptor signaling pathway (GO:0035235)5.52768669
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.42559670
13G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.40144654
14vocalization behavior (GO:0071625)5.36439699
15sodium ion export (GO:0071436)5.32415201
16glutamate receptor signaling pathway (GO:0007215)5.27009206
17neurotransmitter secretion (GO:0007269)5.05863323
18synaptic transmission, glutamatergic (GO:0035249)5.01828867
19pyrimidine nucleobase catabolic process (GO:0006208)5.00167338
20synaptic vesicle exocytosis (GO:0016079)4.99540582
21cell differentiation in hindbrain (GO:0021533)4.95492182
22postsynaptic membrane organization (GO:0001941)4.94507946
23regulation of synaptic vesicle exocytosis (GO:2000300)4.83754496
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.80660338
25positive regulation of synapse maturation (GO:0090129)4.72559132
26neuron recognition (GO:0008038)4.63796952
27glutamate secretion (GO:0014047)4.60812401
28neuron-neuron synaptic transmission (GO:0007270)4.60440269
29presynaptic membrane organization (GO:0097090)4.59100334
30presynaptic membrane assembly (GO:0097105)4.56689401
31long-term memory (GO:0007616)4.56377628
32gamma-aminobutyric acid signaling pathway (GO:0007214)4.47365297
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.43421467
34axonal fasciculation (GO:0007413)4.42141212
35regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.38151800
36exploration behavior (GO:0035640)4.32164213
37short-term memory (GO:0007614)4.30991117
38neuromuscular process controlling posture (GO:0050884)4.26749693
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.23703933
40regulation of synaptic vesicle transport (GO:1902803)4.22209711
41regulation of glutamate receptor signaling pathway (GO:1900449)4.18133289
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.17715195
43synaptic vesicle docking involved in exocytosis (GO:0016081)4.17314019
44layer formation in cerebral cortex (GO:0021819)4.05963389
45neuromuscular process controlling balance (GO:0050885)4.02561699
46neurotransmitter transport (GO:0006836)3.99310298
47regulation of synapse structural plasticity (GO:0051823)3.98153470
48nucleobase catabolic process (GO:0046113)3.95740062
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.94893090
50cerebellar Purkinje cell layer development (GO:0021680)3.90734484
51neurotransmitter-gated ion channel clustering (GO:0072578)3.90492735
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.89755282
53potassium ion import (GO:0010107)3.89729830
54establishment of mitochondrion localization (GO:0051654)3.87875061
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.87427238
56transmission of nerve impulse (GO:0019226)3.82862871
57cell communication by electrical coupling (GO:0010644)3.79892710
58membrane depolarization during action potential (GO:0086010)3.79550985
59prepulse inhibition (GO:0060134)3.78424375
60regulation of neurotransmitter levels (GO:0001505)3.77352113
61neuronal ion channel clustering (GO:0045161)3.76207606
62C4-dicarboxylate transport (GO:0015740)3.74737945
63cell migration in hindbrain (GO:0021535)3.69527424
64adult walking behavior (GO:0007628)3.68485012
65protein localization to synapse (GO:0035418)3.67795976
66regulation of postsynaptic membrane potential (GO:0060078)3.64734410
67regulation of synapse maturation (GO:0090128)3.63664606
68regulation of neuronal synaptic plasticity (GO:0048168)3.62474050
69positive regulation of membrane potential (GO:0045838)3.60843000
70glycine transport (GO:0015816)3.59665190
71negative regulation of synaptic transmission, GABAergic (GO:0032229)3.59213520
72synaptic vesicle endocytosis (GO:0048488)3.58792449
73potassium ion homeostasis (GO:0055075)3.58459978
74auditory behavior (GO:0031223)3.57482657
75cellular sodium ion homeostasis (GO:0006883)3.56912245
76regulation of voltage-gated calcium channel activity (GO:1901385)3.56513557
77behavioral response to nicotine (GO:0035095)3.51984623
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50830077
79central nervous system projection neuron axonogenesis (GO:0021952)3.50529703
80regulation of neurotransmitter secretion (GO:0046928)3.47536883
81long term synaptic depression (GO:0060292)3.45381127
82membrane depolarization (GO:0051899)3.45093473
83adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.42835896
84establishment of nucleus localization (GO:0040023)3.38337002
85positive regulation of dendritic spine development (GO:0060999)3.36815933
86membrane hyperpolarization (GO:0060081)3.36516362
87neuron cell-cell adhesion (GO:0007158)3.36243022
88establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.35690870
89mitochondrion transport along microtubule (GO:0047497)3.35690870
90activation of protein kinase A activity (GO:0034199)3.35615060
91regulation of synaptic transmission, glutamatergic (GO:0051966)3.35086000
92positive regulation of potassium ion transmembrane transport (GO:1901381)3.32096181
93dendrite morphogenesis (GO:0048813)3.31972211
94dendritic spine morphogenesis (GO:0060997)3.31165838
95synapse organization (GO:0050808)3.29159986
96negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.25127524
97mechanosensory behavior (GO:0007638)3.24529407
98regulation of neurotransmitter transport (GO:0051588)3.24009534
99neurofilament cytoskeleton organization (GO:0060052)3.23825327
100retinal cone cell development (GO:0046549)3.23802185
101neuromuscular process (GO:0050905)3.22671280
102positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.21229256
103regulation of ARF protein signal transduction (GO:0032012)3.19196827
104long-term synaptic potentiation (GO:0060291)3.15994773
105synapse assembly (GO:0007416)3.13934649
106dendritic spine organization (GO:0097061)3.12848645
107regulation of synaptic plasticity (GO:0048167)3.12369263
108regulation of vesicle fusion (GO:0031338)3.11053123
109mating behavior (GO:0007617)3.10583827
110regulation of dendritic spine morphogenesis (GO:0061001)3.09223883
111multicellular organismal movement (GO:0050879)3.08445292
112musculoskeletal movement (GO:0050881)3.08445292
113negative regulation of hormone biosynthetic process (GO:0032353)3.06893125
114negative regulation of hormone metabolic process (GO:0032351)3.06893125
115acidic amino acid transport (GO:0015800)3.06797694
116membrane repolarization (GO:0086009)3.06726546
117response to auditory stimulus (GO:0010996)3.05626331
118positive regulation of synapse assembly (GO:0051965)3.04925374
119behavioral response to cocaine (GO:0048148)3.02555443
120proline transport (GO:0015824)3.01533938
121synaptic transmission (GO:0007268)3.00915171
122regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.97189421
123regulation of calcium ion-dependent exocytosis (GO:0017158)2.97074397
124neuromuscular synaptic transmission (GO:0007274)2.96630065
125regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96215950
126positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95711462
127retinal ganglion cell axon guidance (GO:0031290)2.94872317
128L-glutamate transport (GO:0015813)2.94176047
129innervation (GO:0060384)2.91993710
130chemosensory behavior (GO:0007635)2.89057006
131heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.88055709
132retina layer formation (GO:0010842)2.85699203
133adult behavior (GO:0030534)2.82978205

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.79851496
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.44189813
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09379676
4DROSHA_22980978_ChIP-Seq_HELA_Human3.07539678
5IKZF1_21737484_ChIP-ChIP_HCT116_Human3.04000024
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98448215
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.97004390
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.97004390
9REST_21632747_ChIP-Seq_MESCs_Mouse2.85043660
10GBX2_23144817_ChIP-Seq_PC3_Human2.72836832
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68253678
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.65630540
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59603950
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54336651
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53501974
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52732290
17* RARB_27405468_Chip-Seq_BRAIN_Mouse2.52105175
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49143518
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.43920386
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.36762374
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.29227899
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.25082739
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.23919980
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20817184
25RBPJ_22232070_ChIP-Seq_NCS_Mouse2.20399459
26* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14633042
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02447586
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99892900
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94951384
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.91140720
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78667680
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77755764
33* RNF2_27304074_Chip-Seq_NSC_Mouse1.75323074
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66271927
35ZNF274_21170338_ChIP-Seq_K562_Hela1.63531026
36FUS_26573619_Chip-Seq_HEK293_Human1.54903005
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.52213699
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47602474
39KDM2B_26808549_Chip-Seq_K562_Human1.44718877
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43308961
41AR_21572438_ChIP-Seq_LNCaP_Human1.42872694
42AR_19668381_ChIP-Seq_PC3_Human1.39961752
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39621256
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38574833
45* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37491127
46TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37256473
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36479059
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34970190
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34753789
50GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27323948
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26788793
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.25867067
53KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24268741
54VDR_22108803_ChIP-Seq_LS180_Human1.23374876
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21413866
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.20681450
57IGF1R_20145208_ChIP-Seq_DFB_Human1.19750619
58* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19236941
59* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18840586
60STAT3_23295773_ChIP-Seq_U87_Human1.18616194
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18471579
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15654437
63* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12999156
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12526798
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.11109390
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10520898
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10068866
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.09916122
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09076951
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07813231
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07578569
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06520793
73LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06175557
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06005316
75* AR_25329375_ChIP-Seq_VCAP_Human1.05469176
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04920447
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04584298
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.04417744
79TP53_16413492_ChIP-PET_HCT116_Human1.04389634
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03942360
81TCF4_23295773_ChIP-Seq_U87_Human1.03733586
82* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03578078
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03391568
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02568691
85OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02355675
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01457607
87YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99765286
88P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99047151
89TAF15_26573619_Chip-Seq_HEK293_Human0.98959065
90ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98595610
91* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98281015
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97927883
93* TET1_21490601_ChIP-Seq_MESCs_Mouse0.97104204
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97021955
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96644603
96* SMAD3_21741376_ChIP-Seq_ESCs_Human0.95805990
97PIAS1_25552417_ChIP-Seq_VCAP_Human0.95444913
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.95439622
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95424050
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94294516
101CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93934363
102SMAD3_21741376_ChIP-Seq_EPCs_Human0.93928433
103STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93902898
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.93644506
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92715017
106ARNT_22903824_ChIP-Seq_MCF-7_Human0.91871085
107* SOX9_26525672_Chip-Seq_HEART_Mouse0.91675857
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91070004
109RXR_22108803_ChIP-Seq_LS180_Human0.90902498
110TP53_20018659_ChIP-ChIP_R1E_Mouse0.90828921
111SMAD4_21741376_ChIP-Seq_EPCs_Human0.90379550
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90006979
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89646191
114RUNX2_22187159_ChIP-Seq_PCA_Human0.89503249
115BCAT_22108803_ChIP-Seq_LS180_Human0.89423547
116* P300_19829295_ChIP-Seq_ESCs_Human0.88274054
117JUN_21703547_ChIP-Seq_K562_Human0.87716968
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87297488
119KDM2B_26808549_Chip-Seq_REH_Human0.86834867
120ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86669747
121TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85851747
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.85436776
123AHR_22903824_ChIP-Seq_MCF-7_Human0.84648954
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84451640
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84451640
126KLF4_19829295_ChIP-Seq_ESCs_Human0.82697733
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82496049
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81938319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.16600375
2MP0009046_muscle_twitch5.02190555
3MP0003635_abnormal_synaptic_transmissio4.27294977
4MP0009745_abnormal_behavioral_response3.44688225
5MP0008569_lethality_at_weaning3.39812581
6MP0002064_seizures3.32036966
7MP0003880_abnormal_central_pattern3.28485906
8MP0004270_analgesia3.19826989
9MP0002272_abnormal_nervous_system3.16299156
10MP0002063_abnormal_learning/memory/cond3.07276265
11MP0001968_abnormal_touch/_nociception2.97166520
12MP0005423_abnormal_somatic_nervous2.96540243
13MP0002734_abnormal_mechanical_nocicepti2.76258631
14MP0002572_abnormal_emotion/affect_behav2.75434898
15MP0004145_abnormal_muscle_electrophysio2.60032155
16MP0002067_abnormal_sensory_capabilities2.55324308
17MP0001486_abnormal_startle_reflex2.44611965
18MP0001440_abnormal_grooming_behavior2.40641810
19MP0002736_abnormal_nociception_after2.37668499
20MP0001501_abnormal_sleep_pattern2.36749310
21MP0002184_abnormal_innervation2.31237073
22MP0002735_abnormal_chemical_nociception2.29777275
23MP0002822_catalepsy2.22831773
24MP0002733_abnormal_thermal_nociception1.99547586
25MP0001970_abnormal_pain_threshold1.93482730
26MP0005386_behavior/neurological_phenoty1.87257312
27MP0004924_abnormal_behavior1.87257312
28MP0003329_amyloid_beta_deposits1.86279278
29MP0002557_abnormal_social/conspecific_i1.84225781
30MP0004885_abnormal_endolymph1.83088015
31MP0004142_abnormal_muscle_tone1.73681984
32MP0002909_abnormal_adrenal_gland1.64985665
33MP0000955_abnormal_spinal_cord1.62156402
34MP0004811_abnormal_neuron_physiology1.59909048
35MP0002066_abnormal_motor_capabilities/c1.58831091
36MP0004147_increased_porphyrin_level1.58386379
37MP0004742_abnormal_vestibular_system1.51344463
38MP0003632_abnormal_nervous_system1.46581204
39MP0003879_abnormal_hair_cell1.46226498
40MP0001984_abnormal_olfaction1.46118994
41MP0003633_abnormal_nervous_system1.40055924
42MP0002882_abnormal_neuron_morphology1.39657912
43MP0000778_abnormal_nervous_system1.39460298
44MP0003631_nervous_system_phenotype1.33360253
45MP0004858_abnormal_nervous_system1.32828101
46MP0001502_abnormal_circadian_rhythm1.32617821
47MP0009780_abnormal_chondrocyte_physiolo1.25417073
48MP0005248_abnormal_Harderian_gland1.20687775
49MP0008872_abnormal_physiological_respon1.20585701
50MP0005551_abnormal_eye_electrophysiolog1.19084122
51MP0002102_abnormal_ear_morphology1.18234733
52MP0003121_genomic_imprinting1.17600707
53MP0002152_abnormal_brain_morphology1.16587005
54MP0003690_abnormal_glial_cell1.15537005
55MP0002229_neurodegeneration1.12490942
56MP0004133_heterotaxia1.10458116
57MP0001529_abnormal_vocalization1.07357454
58MP0000013_abnormal_adipose_tissue1.07208965
59MP0000920_abnormal_myelination1.07128484
60MP0004215_abnormal_myocardial_fiber1.06806031
61MP0004043_abnormal_pH_regulation1.03364750
62MP0001905_abnormal_dopamine_level1.02307236
63MP0000569_abnormal_digit_pigmentation1.00242319
64MP0005646_abnormal_pituitary_gland1.00006491
65MP0003861_abnormal_nervous_system0.99508846
66MP0003123_paternal_imprinting0.96084508
67MP0000631_abnormal_neuroendocrine_gland0.94660077
68MP0003137_abnormal_impulse_conducting0.94419728
69MP0003283_abnormal_digestive_organ0.94096830
70MP0003787_abnormal_imprinting0.92776168
71MP0006276_abnormal_autonomic_nervous0.92200933
72MP0003890_abnormal_embryonic-extraembry0.92186718
73MP0005253_abnormal_eye_physiology0.89396714
74MP0001188_hyperpigmentation0.88229351
75MP0000026_abnormal_inner_ear0.86070721
76MP0002069_abnormal_eating/drinking_beha0.85748893
77MP0008874_decreased_physiological_sensi0.85609767
78MP0005645_abnormal_hypothalamus_physiol0.85595774
79MP0001177_atelectasis0.83835488
80MP0004085_abnormal_heartbeat0.82644248
81MP0000604_amyloidosis0.82560324
82MP0000566_synostosis0.81973516
83MP0000751_myopathy0.81686717
84MP0002638_abnormal_pupillary_reflex0.81432772
85MP0000534_abnormal_ureter_morphology0.80146445
86MP0001346_abnormal_lacrimal_gland0.79504931
87MP0004233_abnormal_muscle_weight0.78957590
88MP0001299_abnormal_eye_distance/0.78405935
89MP0002089_abnormal_postnatal_growth/wei0.78388709
90MP0003634_abnormal_glial_cell0.77263881
91MP0006072_abnormal_retinal_apoptosis0.76921103
92MP0004484_altered_response_of0.76216792
93MP0005195_abnormal_posterior_eye0.75931073
94MP0003119_abnormal_digestive_system0.75194137
95MP0001963_abnormal_hearing_physiology0.74787924
96MP0002752_abnormal_somatic_nervous0.72880471
97MP0003045_fibrosis0.71393026
98MP0005394_taste/olfaction_phenotype0.70494894
99MP0005499_abnormal_olfactory_system0.70494894
100MP0005187_abnormal_penis_morphology0.67698667
101MP0001485_abnormal_pinna_reflex0.66649017
102MP0002090_abnormal_vision0.66572128
103MP0008961_abnormal_basal_metabolism0.66314127
104MP0001986_abnormal_taste_sensitivity0.65866398
105MP0005535_abnormal_body_temperature0.65730601
106MP0005410_abnormal_fertilization0.65264541
107MP0003122_maternal_imprinting0.65148100
108MP0000537_abnormal_urethra_morphology0.65009665
109MP0010769_abnormal_survival0.64943521
110MP0005083_abnormal_biliary_tract0.64895375
111MP0002081_perinatal_lethality0.64184499
112MP0003698_abnormal_male_reproductive0.63855165
113MP0004510_myositis0.62460484
114MP0002751_abnormal_autonomic_nervous0.62236122
115MP0010768_mortality/aging0.61573499
116MP0005167_abnormal_blood-brain_barrier0.60855593
117MP0010770_preweaning_lethality0.60147037
118MP0002082_postnatal_lethality0.60147037
119MP0003646_muscle_fatigue0.57267376
120MP0010386_abnormal_urinary_bladder0.56176567
121MP0001943_abnormal_respiration0.53004799
122MP0003956_abnormal_body_size0.52876987
123MP0000747_muscle_weakness0.52106858

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)7.23324220
2Progressive cerebellar ataxia (HP:0002073)6.85408944
3Focal motor seizures (HP:0011153)6.68345823
4Myokymia (HP:0002411)6.23607950
5Visual hallucinations (HP:0002367)5.96141231
6Gaze-evoked nystagmus (HP:0000640)5.69541193
7Focal seizures (HP:0007359)5.61067678
8Scanning speech (HP:0002168)5.13861955
9Dysmetric saccades (HP:0000641)5.08197691
10Atonic seizures (HP:0010819)4.92830446
11Dysdiadochokinesis (HP:0002075)4.90655524
12Febrile seizures (HP:0002373)4.74992147
13Impaired smooth pursuit (HP:0007772)4.64591141
14Abnormality of ocular smooth pursuit (HP:0000617)4.30137493
15Broad-based gait (HP:0002136)4.28083419
16Epileptic encephalopathy (HP:0200134)4.27606397
17Hemiplegia (HP:0002301)4.27369592
18Intention tremor (HP:0002080)4.16308925
19Absence seizures (HP:0002121)4.16204513
20Truncal ataxia (HP:0002078)3.97577997
21Dysmetria (HP:0001310)3.93573316
22Genetic anticipation (HP:0003743)3.90723528
23Poor eye contact (HP:0000817)3.65555756
24Abnormality of the lower motor neuron (HP:0002366)3.65004005
25Dialeptic seizures (HP:0011146)3.63517653
26Hemiparesis (HP:0001269)3.57184631
27Diplopia (HP:0000651)3.55758980
28Abnormality of binocular vision (HP:0011514)3.55758980
29Tetraplegia (HP:0002445)3.52670461
30Generalized tonic-clonic seizures (HP:0002069)3.47491292
31Abnormal social behavior (HP:0012433)3.35301074
32Impaired social interactions (HP:0000735)3.35301074
33Postural tremor (HP:0002174)3.31184172
34Annular pancreas (HP:0001734)3.30930091
35Status epilepticus (HP:0002133)3.28272961
36Depression (HP:0000716)3.24538081
37Horizontal nystagmus (HP:0000666)3.18238348
38Abnormality of saccadic eye movements (HP:0000570)3.04203137
39Polyphagia (HP:0002591)3.00838096
40Anxiety (HP:0000739)2.95740124
41Ventricular fibrillation (HP:0001663)2.91285236
42Limb ataxia (HP:0002070)2.85776257
43Supranuclear gaze palsy (HP:0000605)2.84065066
44Abnormal eating behavior (HP:0100738)2.75628419
45Postural instability (HP:0002172)2.68975260
46Impaired vibration sensation in the lower limbs (HP:0002166)2.59921134
47Mutism (HP:0002300)2.59636630
48Gait ataxia (HP:0002066)2.57235295
49Amyotrophic lateral sclerosis (HP:0007354)2.54715320
50Agitation (HP:0000713)2.50337230
51Ankle clonus (HP:0011448)2.41110785
52Lower limb asymmetry (HP:0100559)2.39445463
53Abnormality of the corticospinal tract (HP:0002492)2.38444635
54Stereotypic behavior (HP:0000733)2.38362310
55Pointed chin (HP:0000307)2.36868037
56Double outlet right ventricle (HP:0001719)2.36174813
57Congenital malformation of the right heart (HP:0011723)2.36174813
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.35473258
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.35473258
60Spastic gait (HP:0002064)2.32998332
61Bundle branch block (HP:0011710)2.30660116
62Gait imbalance (HP:0002141)2.25978445
63Neuronal loss in central nervous system (HP:0002529)2.25546891
64Akinesia (HP:0002304)2.25408139
65Urinary bladder sphincter dysfunction (HP:0002839)2.23482050
66Cerebral inclusion bodies (HP:0100314)2.22623907
67Spinal canal stenosis (HP:0003416)2.22196846
68Intestinal atresia (HP:0011100)2.19831184
69Myotonia (HP:0002486)2.13936191
70Cutaneous finger syndactyly (HP:0010554)2.13489438
71Sleep apnea (HP:0010535)2.13002204
72Hyperventilation (HP:0002883)2.12933493
73Drooling (HP:0002307)2.12279400
74Excessive salivation (HP:0003781)2.12279400
75Morphological abnormality of the pyramidal tract (HP:0002062)2.10451873
76Psychosis (HP:0000709)2.08694942
77Deep palmar crease (HP:0006191)2.08091274
78Bony spicule pigmentary retinopathy (HP:0007737)2.05494516
79Failure to thrive in infancy (HP:0001531)2.04093633
80Fetal akinesia sequence (HP:0001989)2.03103429
81Bradykinesia (HP:0002067)2.02955551
82Oligodactyly (hands) (HP:0001180)2.02219738
83Esophageal atresia (HP:0002032)2.01663658
84Slow progression (HP:0003677)2.01443661
85Incomplete penetrance (HP:0003829)2.00068739
86Progressive inability to walk (HP:0002505)1.97700866
87Craniofacial dystonia (HP:0012179)1.96356630
88Pheochromocytoma (HP:0002666)1.96116163
89Focal dystonia (HP:0004373)1.95765291
90EEG with generalized epileptiform discharges (HP:0011198)1.95284566
91Epileptiform EEG discharges (HP:0011182)1.95212751
92Torticollis (HP:0000473)1.94129229
93Lissencephaly (HP:0001339)1.92833521
94Clonus (HP:0002169)1.92768478
95Impaired vibratory sensation (HP:0002495)1.91197236
96Megalencephaly (HP:0001355)1.90902561
97Esotropia (HP:0000565)1.89309324
98Amblyopia (HP:0000646)1.89185912
99Hypoplasia of the brainstem (HP:0002365)1.88636741
100Aplasia/Hypoplasia of the brainstem (HP:0007362)1.88636741
101Oligodactyly (HP:0012165)1.88249700
102Abnormality of the parathyroid morphology (HP:0011766)1.87822620
103Urinary urgency (HP:0000012)1.86202353
104Hypsarrhythmia (HP:0002521)1.86073864
105Absent speech (HP:0001344)1.84592304
106Lower limb muscle weakness (HP:0007340)1.79896551
107Cutaneous syndactyly (HP:0012725)1.79248493
108Pachygyria (HP:0001302)1.78289356
109Aplasia involving bones of the upper limbs (HP:0009823)1.78094823
110Aplasia of the phalanges of the hand (HP:0009802)1.78094823
111Aplasia involving bones of the extremities (HP:0009825)1.78094823
112Labial hypoplasia (HP:0000066)1.77506167
113Neoplasm of the heart (HP:0100544)1.77345205
114Aqueductal stenosis (HP:0002410)1.77041496
115Spastic tetraparesis (HP:0001285)1.74408827
116Chin dimple (HP:0010751)1.73596121
117Optic nerve hypoplasia (HP:0000609)1.73113403
118Renal hypoplasia (HP:0000089)1.72415953
119Papilledema (HP:0001085)1.72335537
120Peripheral hypomyelination (HP:0007182)1.70884854
121Limb dystonia (HP:0002451)1.70032187
122Hand muscle atrophy (HP:0009130)1.69529770
123Heterochromia iridis (HP:0001100)1.69381436
124Insomnia (HP:0100785)1.68165597
125Split foot (HP:0001839)1.66652103
126Rigidity (HP:0002063)1.63609411
127Spastic tetraplegia (HP:0002510)1.63067571
128Hypoplastic nipples (HP:0002557)1.62873817
129Cortical dysplasia (HP:0002539)1.61909153
130Neurofibrillary tangles (HP:0002185)1.61670132
131Confusion (HP:0001289)1.60922531
132Neuroendocrine neoplasm (HP:0100634)1.60825123
133Abnormal EKG (HP:0003115)1.60098490
134Distal upper limb amyotrophy (HP:0007149)1.59980550
135Upper limb amyotrophy (HP:0009129)1.59980550
136Prolonged QT interval (HP:0001657)1.56455368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.98555429
2CAMKK23.95733047
3MAP3K93.42848386
4RIPK13.07306375
5MAP3K42.85151549
6CAMKK12.82437976
7MINK12.62027422
8NTRK22.40922273
9DAPK22.32593299
10WNK12.31944942
11PAK62.31941989
12STK382.19231172
13MARK12.19064828
14MAP2K72.14079069
15MAP2K42.05967753
16EPHA42.04874908
17CDK191.95151643
18PRPF4B1.85581631
19DYRK21.83689972
20RIPK41.80511694
21CSNK1G21.50866844
22KSR21.47597945
23PRKCG1.46907025
24LATS21.44182812
25CDK51.38842880
26PNCK1.38707936
27TYRO31.36463215
28TNIK1.34097022
29SGK2231.32593019
30SGK4941.32593019
31SIK21.31799929
32NTRK11.31737097
33SGK21.30633060
34PINK11.28659284
35GRK51.26487868
36CAMK11.22832694
37SGK31.20447521
38PRKCH1.18489777
39PRKD31.18435988
40ALK1.16248758
41BCR1.14017822
42KSR11.13678313
43MAP3K121.13420440
44STK111.12375597
45UHMK11.07237048
46CDK151.06373807
47CDK181.04365958
48EPHB21.03380610
49OXSR11.02659344
50DAPK11.01640218
51CAMK40.99523908
52MAPK130.95896566
53FES0.93508426
54CDK11A0.93012353
55CDK140.92388258
56RET0.89042222
57PHKG20.87552946
58PHKG10.87552946
59CAMK2B0.86550364
60PLK20.86517513
61PKN10.86397983
62CAMK2G0.85329967
63DYRK1A0.83847169
64CAMK1G0.82740749
65CAMK2A0.82479322
66CDC42BPA0.81723433
67PDK10.81343088
68CSNK1G30.79939909
69TESK10.79304250
70MAPKAPK50.78657644
71SGK10.78147249
72MAP3K130.77607116
73TRIM280.74541608
74CASK0.73448463
75CAMK2D0.73079355
76CSNK1A1L0.72370681
77WNK30.71825966
78MAP3K20.68714997
79TNK20.66975594
80PDPK10.65826787
81RPS6KA30.64022917
82MARK20.63160103
83BRAF0.62787522
84CSNK1G10.62201886
85NEK60.61266526
86FYN0.61038016
87FGFR20.60349866
88LMTK20.59901916
89ARAF0.59820191
90ROCK20.59634901
91TAOK10.59405759
92ERBB40.59317050
93BMPR1B0.58687834
94PTK60.57341445
95PRKG10.56040246
96NEK10.53395772
97BRD40.50974614
98CSNK1D0.49578647
99HIPK20.47052457
100SCYL20.46138500
101PTK20.46039717
102AKT30.46019599
103BMPR20.45313383
104MAPK100.43998801
105MKNK20.41883645
106CDK30.41829174
107PRKACA0.41585141
108PRKCZ0.40747214
109CSNK1E0.40652588
110ERBB20.40063780
111PRKCB0.38132337
112ERBB30.37549749
113SRC0.37452808
114PTK2B0.36165707
115PRKDC0.35870445
116PRKCA0.35850762
117PRKACB0.35174144
118PRKACG0.35039957
119PAK30.34576792
120MAPK120.34411948
121MAPK80.34013771
122TAOK20.33661881
123PRKCE0.33449626
124INSRR0.33201592
125RPS6KA20.31314659
126MAP3K60.30406705
127MAP4K20.30242137
128BRSK10.29762443

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.35012286
2Glutamatergic synapse_Homo sapiens_hsa047243.05361032
3Synaptic vesicle cycle_Homo sapiens_hsa047212.99659575
4Long-term potentiation_Homo sapiens_hsa047202.95968824
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.95514806
6GABAergic synapse_Homo sapiens_hsa047272.85211958
7Circadian entrainment_Homo sapiens_hsa047132.80833960
8Morphine addiction_Homo sapiens_hsa050322.54897684
9Long-term depression_Homo sapiens_hsa047302.52828705
10Salivary secretion_Homo sapiens_hsa049702.33346992
11Taste transduction_Homo sapiens_hsa047422.23941212
12Amphetamine addiction_Homo sapiens_hsa050312.22997131
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22056177
14Olfactory transduction_Homo sapiens_hsa047402.15783251
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.10336030
16Dopaminergic synapse_Homo sapiens_hsa047281.97359499
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.96098968
18Gastric acid secretion_Homo sapiens_hsa049711.95153796
19Insulin secretion_Homo sapiens_hsa049111.81543530
20Cholinergic synapse_Homo sapiens_hsa047251.78981855
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65455579
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63803538
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.59972539
24Oxytocin signaling pathway_Homo sapiens_hsa049211.57864383
25Calcium signaling pathway_Homo sapiens_hsa040201.54470067
26Type II diabetes mellitus_Homo sapiens_hsa049301.45203780
27Renin secretion_Homo sapiens_hsa049241.43361624
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40727466
29Serotonergic synapse_Homo sapiens_hsa047261.39669816
30GnRH signaling pathway_Homo sapiens_hsa049121.32059389
31Gap junction_Homo sapiens_hsa045401.31695314
32Cocaine addiction_Homo sapiens_hsa050301.30828756
33cAMP signaling pathway_Homo sapiens_hsa040241.30644920
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29483889
35Pancreatic secretion_Homo sapiens_hsa049721.26895255
36Estrogen signaling pathway_Homo sapiens_hsa049151.21345851
37Nitrogen metabolism_Homo sapiens_hsa009101.18448385
38Thyroid hormone synthesis_Homo sapiens_hsa049181.12552388
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06219470
40Cardiac muscle contraction_Homo sapiens_hsa042601.04583306
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02300265
42Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95891269
43Phospholipase D signaling pathway_Homo sapiens_hsa040720.93645979
44Alzheimers disease_Homo sapiens_hsa050100.93212661
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87080161
46Inositol phosphate metabolism_Homo sapiens_hsa005620.86672424
47Oocyte meiosis_Homo sapiens_hsa041140.83865054
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.82175450
49Melanogenesis_Homo sapiens_hsa049160.81720893
50Bile secretion_Homo sapiens_hsa049760.81633178
51Collecting duct acid secretion_Homo sapiens_hsa049660.81301771
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79960610
53Glioma_Homo sapiens_hsa052140.79655272
54Dilated cardiomyopathy_Homo sapiens_hsa054140.76577557
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75694637
56ErbB signaling pathway_Homo sapiens_hsa040120.72830774
57Choline metabolism in cancer_Homo sapiens_hsa052310.69972474
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69219240
59Circadian rhythm_Homo sapiens_hsa047100.67912392
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64746808
61Phototransduction_Homo sapiens_hsa047440.63912028
62Parkinsons disease_Homo sapiens_hsa050120.63056816
63MAPK signaling pathway_Homo sapiens_hsa040100.62958257
64Dorso-ventral axis formation_Homo sapiens_hsa043200.61212998
65Axon guidance_Homo sapiens_hsa043600.61122593
66mTOR signaling pathway_Homo sapiens_hsa041500.58590882
67Hippo signaling pathway_Homo sapiens_hsa043900.58492174
68Oxidative phosphorylation_Homo sapiens_hsa001900.58179211
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57507724
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54357051
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54094906
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.53417596
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49750439
74Hedgehog signaling pathway_Homo sapiens_hsa043400.49616880
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46413256
76Colorectal cancer_Homo sapiens_hsa052100.46248447
77VEGF signaling pathway_Homo sapiens_hsa043700.46245084
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45788436
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45253842
80Glucagon signaling pathway_Homo sapiens_hsa049220.44175062
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42834319
82Rap1 signaling pathway_Homo sapiens_hsa040150.42630779
83Huntingtons disease_Homo sapiens_hsa050160.42346596
84Tight junction_Homo sapiens_hsa045300.42177155
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42011557
86Mineral absorption_Homo sapiens_hsa049780.40277406
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.39278783
88Endocytosis_Homo sapiens_hsa041440.39126069
89Fatty acid biosynthesis_Homo sapiens_hsa000610.38592388
90Alcoholism_Homo sapiens_hsa050340.38451361
91Prion diseases_Homo sapiens_hsa050200.37700901
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37304587
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36863224
94Basal cell carcinoma_Homo sapiens_hsa052170.36640974
95Non-small cell lung cancer_Homo sapiens_hsa052230.35412315
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35272571
97Vibrio cholerae infection_Homo sapiens_hsa051100.35111937
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34305268
99Arginine biosynthesis_Homo sapiens_hsa002200.33694660
100Chemokine signaling pathway_Homo sapiens_hsa040620.33357488
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32555138
102Butanoate metabolism_Homo sapiens_hsa006500.32267872
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29887726
104Endometrial cancer_Homo sapiens_hsa052130.29869289
105Platelet activation_Homo sapiens_hsa046110.29464509
106Ovarian steroidogenesis_Homo sapiens_hsa049130.28527592
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28502287
108Ras signaling pathway_Homo sapiens_hsa040140.28219507
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.25888869
110Type I diabetes mellitus_Homo sapiens_hsa049400.25694795
111Proteoglycans in cancer_Homo sapiens_hsa052050.22972779
112Renal cell carcinoma_Homo sapiens_hsa052110.22560982
113African trypanosomiasis_Homo sapiens_hsa051430.22100051
114Wnt signaling pathway_Homo sapiens_hsa043100.21159282
115Insulin signaling pathway_Homo sapiens_hsa049100.20809590
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.20709991

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