RGS9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic transmission, dopaminergic (GO:0001963)6.47001060
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.77293560
3prepulse inhibition (GO:0060134)5.65944165
4striatum development (GO:0021756)5.46570641
5* regulation of rhodopsin mediated signaling pathway (GO:0022400)5.40351545
6behavioral response to nicotine (GO:0035095)5.30860184
7* rhodopsin mediated signaling pathway (GO:0016056)5.28067701
8regulation of short-term neuronal synaptic plasticity (GO:0048172)5.27947888
9adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.17005417
10regulation of synapse structural plasticity (GO:0051823)5.15121567
11positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.14265667
12synaptic vesicle maturation (GO:0016188)5.10921966
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.94994815
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.93323616
15regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.89271124
16regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.89271124
17locomotory exploration behavior (GO:0035641)4.87199017
18adenosine receptor signaling pathway (GO:0001973)4.79470066
19response to amphetamine (GO:0001975)4.75218319
20positive regulation of neurotransmitter transport (GO:0051590)4.74992439
21retinal cone cell development (GO:0046549)4.74963748
22behavioral response to cocaine (GO:0048148)4.64960896
23negative regulation of cytosolic calcium ion concentration (GO:0051481)4.60974486
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.45990140
25auditory behavior (GO:0031223)4.45212974
26water-soluble vitamin biosynthetic process (GO:0042364)4.44686997
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.42211642
28positive regulation of synaptic transmission, GABAergic (GO:0032230)4.35871039
29cAMP catabolic process (GO:0006198)4.35037203
30vocalization behavior (GO:0071625)4.29791642
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.27154686
32regulation of glutamate receptor signaling pathway (GO:1900449)4.26821774
33neurotransmitter-gated ion channel clustering (GO:0072578)4.23429811
34synaptic vesicle docking involved in exocytosis (GO:0016081)4.19990724
35positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.18585957
36regulation of neuronal synaptic plasticity (GO:0048168)4.14516436
37regulation of neurotransmitter uptake (GO:0051580)4.13781109
38protein localization to synapse (GO:0035418)4.12284431
39* dopamine receptor signaling pathway (GO:0007212)4.11718646
40response to auditory stimulus (GO:0010996)4.04086601
41substrate-independent telencephalic tangential migration (GO:0021826)4.03263698
42substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.03263698
43negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.01662416
44regulation of female receptivity (GO:0045924)3.99966135
45regulation of voltage-gated calcium channel activity (GO:1901385)3.97552131
46neuron-neuron synaptic transmission (GO:0007270)3.97106538
47response to histamine (GO:0034776)3.96223942
48membrane hyperpolarization (GO:0060081)3.90983879
49positive regulation of membrane potential (GO:0045838)3.88247833
50cyclic nucleotide catabolic process (GO:0009214)3.87045409
51regulation of synaptic vesicle exocytosis (GO:2000300)3.86521832
52positive regulation of neurotransmitter secretion (GO:0001956)3.85023354
53photoreceptor cell development (GO:0042461)3.81638066
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.81316226
55synaptic vesicle exocytosis (GO:0016079)3.77450370
56regulation of glucokinase activity (GO:0033131)3.71150356
57regulation of hexokinase activity (GO:1903299)3.71150356
58ionotropic glutamate receptor signaling pathway (GO:0035235)3.65791327
59protein complex biogenesis (GO:0070271)3.63801213
60regulation of postsynaptic membrane potential (GO:0060078)3.62303026
61female mating behavior (GO:0060180)3.62275056
62regulation of dendritic spine morphogenesis (GO:0061001)3.62069607
63visual learning (GO:0008542)3.61995682
64eye photoreceptor cell development (GO:0042462)3.61504659
65photoreceptor cell maintenance (GO:0045494)3.61092193
66neurotransmitter secretion (GO:0007269)3.60697845
67long-term memory (GO:0007616)3.60538770
68dendritic spine morphogenesis (GO:0060997)3.59262443
69synaptic transmission, glutamatergic (GO:0035249)3.58450787
70platelet dense granule organization (GO:0060155)3.56993696
71neuromuscular process controlling balance (GO:0050885)3.55835315
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.54374183
73detection of light stimulus involved in visual perception (GO:0050908)3.53467770
74detection of light stimulus involved in sensory perception (GO:0050962)3.53467770
75G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.51612332
76regulation of glutamate secretion (GO:0014048)3.48115666
77behavioral response to ethanol (GO:0048149)3.47779879
78transmission of nerve impulse (GO:0019226)3.46702190
79neuronal ion channel clustering (GO:0045161)3.46561454
80regulation of synaptic vesicle transport (GO:1902803)3.46555868
81behavioral fear response (GO:0001662)3.46085696
82behavioral defense response (GO:0002209)3.46085696
83regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.45396729
84respiratory chain complex IV assembly (GO:0008535)3.42366783
85cAMP metabolic process (GO:0046058)3.42091927
86peristalsis (GO:0030432)3.41898559
87visual behavior (GO:0007632)3.38304031
88neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.35390467
89cellular ketone body metabolic process (GO:0046950)3.35239575
90mitochondrial respiratory chain complex assembly (GO:0033108)3.33407971
91mechanosensory behavior (GO:0007638)3.31684835
92mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31549760
93mitochondrial respiratory chain complex I assembly (GO:0032981)3.31549760
94NADH dehydrogenase complex assembly (GO:0010257)3.31549760
95protein-chromophore linkage (GO:0018298)3.30149484
96positive regulation of guanylate cyclase activity (GO:0031284)3.28415791
97regulation of synaptic transmission, dopaminergic (GO:0032225)3.28381539
98long-term synaptic potentiation (GO:0060291)3.28191328
99protein polyglutamylation (GO:0018095)3.26656919
100phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.26193544
101tryptophan catabolic process (GO:0006569)3.25285593
102indole-containing compound catabolic process (GO:0042436)3.25285593
103indolalkylamine catabolic process (GO:0046218)3.25285593
104exploration behavior (GO:0035640)3.25253753
105DNA deamination (GO:0045006)3.24958961
106regulation of dopamine metabolic process (GO:0042053)3.24176764
107regulation of catecholamine metabolic process (GO:0042069)3.24176764
108response to pheromone (GO:0019236)3.21127631
109glycine transport (GO:0015816)3.20817388
110dopamine transport (GO:0015872)3.20320189
111regulation of synaptic plasticity (GO:0048167)3.20144186
112cGMP metabolic process (GO:0046068)3.19557533
113drinking behavior (GO:0042756)3.19262391
114axoneme assembly (GO:0035082)3.18902480
115neuronal action potential propagation (GO:0019227)3.17402489
116response to amine (GO:0014075)3.17212047
117regulation of neurotransmitter transport (GO:0051588)3.17079239
118* phototransduction (GO:0007602)3.16853266
119kynurenine metabolic process (GO:0070189)3.16703416
120negative regulation of dendrite development (GO:2000171)3.15143249
121regulation of synaptic transmission, GABAergic (GO:0032228)3.14073643
122L-fucose catabolic process (GO:0042355)3.12439791
123fucose catabolic process (GO:0019317)3.12439791
124L-fucose metabolic process (GO:0042354)3.12439791
125cytochrome complex assembly (GO:0017004)3.11459195
126kidney morphogenesis (GO:0060993)3.07276709
127detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.06387019
128protein neddylation (GO:0045116)3.05423713
129indolalkylamine metabolic process (GO:0006586)3.04169625
130inositol phosphate catabolic process (GO:0071545)3.03275455
131ketone body metabolic process (GO:1902224)3.03104532
132sulfation (GO:0051923)3.02232040
133glycerophospholipid catabolic process (GO:0046475)3.00082154
134preassembly of GPI anchor in ER membrane (GO:0016254)2.98352531
135epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94862921
136reflex (GO:0060004)2.94687366
137epithelial cilium movement (GO:0003351)2.92064449
138protein localization to cilium (GO:0061512)2.87533319
139regulation of mesoderm development (GO:2000380)2.80302275
140phosphorylated carbohydrate dephosphorylation (GO:0046838)2.79750255
141inositol phosphate dephosphorylation (GO:0046855)2.79750255
142presynaptic membrane assembly (GO:0097105)2.79161525
143mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79001905
144negative regulation of telomere maintenance (GO:0032205)2.76011530
145negative regulation of transcription regulatory region DNA binding (GO:2000678)2.70652937
146nonmotile primary cilium assembly (GO:0035058)2.68029478
147negative regulation of appetite (GO:0032099)2.67917068
148negative regulation of response to food (GO:0032096)2.67917068
149gamma-aminobutyric acid transport (GO:0015812)2.65682919
150tryptophan metabolic process (GO:0006568)2.61588963
151polyol catabolic process (GO:0046174)2.60794870
152GPI anchor metabolic process (GO:0006505)2.60724489
153neuronal action potential (GO:0019228)2.59917780
154piRNA metabolic process (GO:0034587)2.58457977
155cellular response to ATP (GO:0071318)2.57215407
156keratinocyte development (GO:0003334)2.56994802
157cilium movement (GO:0003341)2.56099309
158regulation of nuclear cell cycle DNA replication (GO:0033262)2.56037713
159regulation of action potential (GO:0098900)2.54983992
160nephron tubule morphogenesis (GO:0072078)2.53574233
161nephron epithelium morphogenesis (GO:0072088)2.53574233
162presynaptic membrane organization (GO:0097090)2.51426242
163protein K6-linked ubiquitination (GO:0085020)2.51324549
164cilium morphogenesis (GO:0060271)2.50246948
165mannosylation (GO:0097502)2.49363533
166insulin secretion (GO:0030073)2.47528064
167cilium organization (GO:0044782)2.47474146
168aromatic amino acid family catabolic process (GO:0009074)2.47017243
169endocrine pancreas development (GO:0031018)2.46775179
170prostate gland growth (GO:0060736)2.46648463
171lactate metabolic process (GO:0006089)2.45384424
172adaptation of signaling pathway (GO:0023058)2.44699496
173indole-containing compound metabolic process (GO:0042430)2.44489752
174positive regulation of fatty acid transport (GO:2000193)2.43109715
175regulation of cilium movement (GO:0003352)2.42403767
176positive regulation of prostaglandin secretion (GO:0032308)2.40146826
177synaptic transmission, cholinergic (GO:0007271)2.39996259
178positive regulation of meiosis (GO:0045836)2.39426925
179cilium assembly (GO:0042384)2.38860668
180proline transport (GO:0015824)2.38403593
1813-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.38015939
182purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.38015939
183replication fork processing (GO:0031297)2.37430138
184calcium ion import (GO:0070509)2.36061480
185startle response (GO:0001964)2.35763841
186phosphatidylinositol acyl-chain remodeling (GO:0036149)2.35708332
187amine catabolic process (GO:0009310)2.35309289
188cellular biogenic amine catabolic process (GO:0042402)2.35309289
189positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.34642599
190spinal cord motor neuron differentiation (GO:0021522)2.34185040
191dentate gyrus development (GO:0021542)2.31604074
192negative regulation of DNA-dependent DNA replication (GO:2000104)2.31058062
193S-adenosylmethionine metabolic process (GO:0046500)2.30565372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.03510082
2EZH2_22144423_ChIP-Seq_EOC_Human4.24747810
3* RARB_27405468_Chip-Seq_BRAIN_Mouse3.61049330
4GBX2_23144817_ChIP-Seq_PC3_Human3.47280616
5ZNF274_21170338_ChIP-Seq_K562_Hela3.39157577
6VDR_22108803_ChIP-Seq_LS180_Human3.00579900
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96755390
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91651134
9DROSHA_22980978_ChIP-Seq_HELA_Human2.84751121
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72785663
11IGF1R_20145208_ChIP-Seq_DFB_Human2.65074957
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57809074
13REST_21632747_ChIP-Seq_MESCs_Mouse2.56984550
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54856305
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54856305
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49736170
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46233150
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42224471
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.39051932
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.37894424
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37420774
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29821716
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.26872318
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25909490
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22845864
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19932147
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.19056659
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18097448
29FUS_26573619_Chip-Seq_HEK293_Human2.16490159
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13603325
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.10290759
32AR_21572438_ChIP-Seq_LNCaP_Human2.09827448
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07815812
34* REST_18959480_ChIP-ChIP_MESCs_Mouse2.06119384
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01950713
36* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99315733
37EWS_26573619_Chip-Seq_HEK293_Human1.95461308
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.88738583
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81855929
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80068553
41ER_23166858_ChIP-Seq_MCF-7_Human1.73622981
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70632316
43BCAT_22108803_ChIP-Seq_LS180_Human1.69783269
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64935139
45IRF1_19129219_ChIP-ChIP_H3396_Human1.63968807
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.61579439
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57935790
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57313098
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53199083
50SMAD4_21799915_ChIP-Seq_A2780_Human1.53121047
51P53_22127205_ChIP-Seq_FIBROBLAST_Human1.48297230
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47906555
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47010974
54* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45525904
55TP53_22573176_ChIP-Seq_HFKS_Human1.45198797
56SOX2_19829295_ChIP-Seq_ESCs_Human1.44053576
57NANOG_19829295_ChIP-Seq_ESCs_Human1.44053576
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43289373
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41332847
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.40539169
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.40175930
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38899497
63MYC_18940864_ChIP-ChIP_HL60_Human1.38111146
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36810147
65CBP_20019798_ChIP-Seq_JUKART_Human1.36810147
66* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36367610
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35844543
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35433463
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34494306
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.34494306
71* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33924927
72* STAT3_23295773_ChIP-Seq_U87_Human1.31844674
73TCF4_22108803_ChIP-Seq_LS180_Human1.30214726
74AR_19668381_ChIP-Seq_PC3_Human1.30180095
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29222240
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27831460
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27062560
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.25603424
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.25116818
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.25059399
81* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25050097
82KDM2B_26808549_Chip-Seq_K562_Human1.24649151
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.22627532
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.20967063
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.20612324
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.20082805
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19995150
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19236839
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.18159951
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17660173
91AR_20517297_ChIP-Seq_VCAP_Human1.16592407
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16051814
93* P300_19829295_ChIP-Seq_ESCs_Human1.14783966
94* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14773028
95TAF15_26573619_Chip-Seq_HEK293_Human1.14040589
96* FLI1_21867929_ChIP-Seq_TH2_Mouse1.13617167
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13284447
98CDX2_22108803_ChIP-Seq_LS180_Human1.13243496
99TCF4_23295773_ChIP-Seq_U87_Human1.12213154
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11994829
101* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11397282
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10232503
103CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09560908
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09358871
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08235676
106GATA3_21878914_ChIP-Seq_MCF-7_Human1.07914355
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.07524933
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07235095
109* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07191493
110NCOR_22424771_ChIP-Seq_293T_Human1.07023914
111AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06724890
112ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06539389
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05019885
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04844980
115P53_22387025_ChIP-Seq_ESCs_Mouse1.04630243
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.04390163
117HOXB7_26014856_ChIP-Seq_BT474_Human1.04190004
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03457576
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03457576
120HTT_18923047_ChIP-ChIP_STHdh_Human1.02867395
121EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02482918
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.02060461
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01340520
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01320615
125ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00912309
126BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00743430
127RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00687795
128* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00601036
129CTCF_27219007_Chip-Seq_Bcells_Human1.00264004
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00217267
131CRX_20693478_ChIP-Seq_RETINA_Mouse1.00134289
132TAL1_26923725_Chip-Seq_HPCs_Mouse0.99954401
133RUNX2_22187159_ChIP-Seq_PCA_Human0.99890497
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99545286
135AHR_22903824_ChIP-Seq_MCF-7_Human0.98326618
136CBX2_27304074_Chip-Seq_ESCs_Mouse0.98217041
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97729211
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.97446275
139TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97179680
140ELK1_19687146_ChIP-ChIP_HELA_Human0.97153437
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96782024
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96150250
143NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96057045
144NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95711102
145AR_25329375_ChIP-Seq_VCAP_Human0.95485394
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94863247
147PIAS1_25552417_ChIP-Seq_VCAP_Human0.94178239
148SMAD3_21741376_ChIP-Seq_ESCs_Human0.93781640
149* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93291398
150CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92664539
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92024897
152RNF2_27304074_Chip-Seq_NSC_Mouse0.91554119
153WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89052700
154CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89009939
155* PRDM14_20953172_ChIP-Seq_ESCs_Human0.88863903
156BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88777978
157NANOG_18555785_Chip-Seq_ESCs_Mouse0.87735749
158ARNT_22903824_ChIP-Seq_MCF-7_Human0.87020442
159RXR_22108803_ChIP-Seq_LS180_Human0.86911220
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86736483
161MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86430798
162POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84997746
163* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84785382
164* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84673638
165SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83645770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy8.39028699
2MP0004859_abnormal_synaptic_plasticity5.23023965
3* MP0005551_abnormal_eye_electrophysiolog4.03201262
4MP0003195_calcinosis3.52147052
5MP0003635_abnormal_synaptic_transmissio3.51021482
6MP0003011_delayed_dark_adaptation3.48559537
7MP0003880_abnormal_central_pattern3.47333160
8MP0009745_abnormal_behavioral_response3.30736910
9MP0005423_abnormal_somatic_nervous3.17749252
10MP0002837_dystrophic_cardiac_calcinosis3.12591798
11MP0002063_abnormal_learning/memory/cond3.03610915
12MP0008877_abnormal_DNA_methylation2.92758153
13MP0004270_analgesia2.81917878
14MP0001486_abnormal_startle_reflex2.76966379
15MP0005253_abnormal_eye_physiology2.69343102
16MP0002064_seizures2.60394725
17MP0005646_abnormal_pituitary_gland2.57962286
18MP0002572_abnormal_emotion/affect_behav2.51898255
19MP0009046_muscle_twitch2.49365680
20MP0002102_abnormal_ear_morphology2.48076553
21MP0006072_abnormal_retinal_apoptosis2.44627305
22MP0001529_abnormal_vocalization2.44513609
23MP0002272_abnormal_nervous_system2.32201673
24MP0002909_abnormal_adrenal_gland2.20859601
25MP0001968_abnormal_touch/_nociception2.15363851
26MP0003136_yellow_coat_color2.13631470
27MP0002876_abnormal_thyroid_physiology2.08432467
28MP0005084_abnormal_gallbladder_morpholo1.99666786
29MP0005409_darkened_coat_color1.97382664
30MP0005379_endocrine/exocrine_gland_phen1.97271184
31MP0001984_abnormal_olfaction1.93948988
32MP0001188_hyperpigmentation1.90271395
33MP0002090_abnormal_vision1.90149078
34MP0002734_abnormal_mechanical_nocicepti1.88171788
35MP0005386_behavior/neurological_phenoty1.84563771
36MP0004924_abnormal_behavior1.84563771
37MP0002163_abnormal_gland_morphology1.82961925
38MP0001501_abnormal_sleep_pattern1.81495687
39MP0004133_heterotaxia1.74648149
40MP0002638_abnormal_pupillary_reflex1.62135524
41MP0002229_neurodegeneration1.59259434
42MP0002938_white_spotting1.57928385
43MP0002557_abnormal_social/conspecific_i1.57913858
44MP0005174_abnormal_tail_pigmentation1.53950330
45MP0001970_abnormal_pain_threshold1.53358603
46MP0003646_muscle_fatigue1.53346919
47MP0001502_abnormal_circadian_rhythm1.50119827
48MP0008569_lethality_at_weaning1.49102069
49MP0000372_irregular_coat_pigmentation1.47005227
50MP0005195_abnormal_posterior_eye1.45332231
51MP0004885_abnormal_endolymph1.42664535
52MP0001485_abnormal_pinna_reflex1.42503241
53MP0002882_abnormal_neuron_morphology1.42367595
54MP0004811_abnormal_neuron_physiology1.39253154
55MP0002067_abnormal_sensory_capabilities1.37922732
56MP0002733_abnormal_thermal_nociception1.37158903
57MP0004147_increased_porphyrin_level1.35043209
58MP0002928_abnormal_bile_duct1.33330383
59MP0002160_abnormal_reproductive_system1.30554882
60MP0002693_abnormal_pancreas_physiology1.28831371
61MP0005645_abnormal_hypothalamus_physiol1.28373193
62MP0004145_abnormal_muscle_electrophysio1.27323552
63MP0009780_abnormal_chondrocyte_physiolo1.27278214
64MP0000427_abnormal_hair_cycle1.26065848
65MP0002736_abnormal_nociception_after1.23503904
66MP0002277_abnormal_respiratory_mucosa1.22010571
67MP0001440_abnormal_grooming_behavior1.18407394
68MP0001177_atelectasis1.17804337
69MP0001905_abnormal_dopamine_level1.17569561
70MP0005389_reproductive_system_phenotype1.17330731
71MP0003075_altered_response_to1.16595565
72MP0005332_abnormal_amino_acid1.14628847
73MP0001324_abnormal_eye_pigmentation1.13881794
74MP0003879_abnormal_hair_cell1.13440361
75MP0008995_early_reproductive_senescence1.11973833
76MP0008875_abnormal_xenobiotic_pharmacok1.10621334
77MP0008872_abnormal_physiological_respon1.10069497
78MP0003633_abnormal_nervous_system1.09490156
79MP0002066_abnormal_motor_capabilities/c1.09288474
80MP0004215_abnormal_myocardial_fiber1.09084050
81MP0001944_abnormal_pancreas_morphology1.08872230
82MP0002752_abnormal_somatic_nervous1.08236535
83MP0002184_abnormal_innervation1.07949984
84MP0000013_abnormal_adipose_tissue1.07843016
85MP0002138_abnormal_hepatobiliary_system1.06508912
86MP0005075_abnormal_melanosome_morpholog1.06270377
87MP0003787_abnormal_imprinting1.01836118
88MP0005394_taste/olfaction_phenotype1.01121268
89MP0005499_abnormal_olfactory_system1.01121268
90MP0005391_vision/eye_phenotype1.00924227
91MP0003121_genomic_imprinting1.00683307
92MP0005365_abnormal_bile_salt1.00208724
93MP0005167_abnormal_blood-brain_barrier0.99894596
94MP0001919_abnormal_reproductive_system0.99318988
95MP0000955_abnormal_spinal_cord0.99120738
96MP0010329_abnormal_lipoprotein_level0.98840376
97MP0000383_abnormal_hair_follicle0.98348783
98MP0001986_abnormal_taste_sensitivity0.97462411
99MP0002735_abnormal_chemical_nociception0.97418662
100MP0008874_decreased_physiological_sensi0.96351335
101MP0000569_abnormal_digit_pigmentation0.96295284
102MP0004085_abnormal_heartbeat0.93923209
103MP0003283_abnormal_digestive_organ0.91724551
104MP0008058_abnormal_DNA_repair0.91006062
105MP0005377_hearing/vestibular/ear_phenot0.90551792
106MP0003878_abnormal_ear_physiology0.90551792
107MP0000631_abnormal_neuroendocrine_gland0.89958211
108MP0008961_abnormal_basal_metabolism0.89716631
109MP0003119_abnormal_digestive_system0.88292115
110MP0002069_abnormal_eating/drinking_beha0.88029273
111MP0000230_abnormal_systemic_arterial0.87845134
112MP0005448_abnormal_energy_balance0.87147759
113MP0005410_abnormal_fertilization0.85709353
114MP0000778_abnormal_nervous_system0.85693556
115MP0006292_abnormal_olfactory_placode0.85134800
116MP0005085_abnormal_gallbladder_physiolo0.85005885
117MP0002751_abnormal_autonomic_nervous0.83907587
118MP0002254_reproductive_system_inflammat0.82406752
119MP0004142_abnormal_muscle_tone0.82078489
120MP0005636_abnormal_mineral_homeostasis0.81854899
121MP0003631_nervous_system_phenotype0.80591091
122MP0003890_abnormal_embryonic-extraembry0.80018198
123MP0005535_abnormal_body_temperature0.79900525
124MP0001756_abnormal_urination0.78046043
125MP0003718_maternal_effect0.77739758
126MP0010386_abnormal_urinary_bladder0.77286312
127MP0002152_abnormal_brain_morphology0.75814466
128MP0003634_abnormal_glial_cell0.72517513
129MP0003690_abnormal_glial_cell0.72044142
130MP0004742_abnormal_vestibular_system0.65531657
131MP0002653_abnormal_ependyma_morphology0.58809807
132MP0004043_abnormal_pH_regulation0.58794383
133MP0000920_abnormal_myelination0.57693829
134MP0006276_abnormal_autonomic_nervous0.57097080
135MP0001963_abnormal_hearing_physiology0.56397192
136MP0003137_abnormal_impulse_conducting0.51453163
137MP0005248_abnormal_Harderian_gland0.46914333
138MP0003122_maternal_imprinting0.46740106
139MP0004233_abnormal_muscle_weight0.45871739
140MP0005310_abnormal_salivary_gland0.43642638
141MP0001664_abnormal_digestion0.43504648
142MP0003329_amyloid_beta_deposits0.42768515
143MP0004858_abnormal_nervous_system0.41729921
144MP0003950_abnormal_plasma_membrane0.41671608
145MP0003045_fibrosis0.39601323
146MP0005166_decreased_susceptibility_to0.39230181
147MP0003632_abnormal_nervous_system0.38694516
148MP0001943_abnormal_respiration0.38676236
149MP0000003_abnormal_adipose_tissue0.38066927

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)8.43675447
2Bony spicule pigmentary retinopathy (HP:0007737)6.95193591
3Myokymia (HP:0002411)6.94767875
4Central scotoma (HP:0000603)6.35122108
5Absent rod-and cone-mediated responses on ERG (HP:0007688)6.18773018
6Abnormal rod and cone electroretinograms (HP:0008323)5.96147981
7Dyschromatopsia (HP:0007641)5.95922351
8Focal motor seizures (HP:0011153)5.78277479
9Scotoma (HP:0000575)5.26148561
10Abnormality of macular pigmentation (HP:0008002)5.23275676
11Pigmentary retinal degeneration (HP:0001146)4.79015938
12Decreased central vision (HP:0007663)4.50351143
13Attenuation of retinal blood vessels (HP:0007843)4.46752687
14Chorioretinal atrophy (HP:0000533)4.25981811
15Focal seizures (HP:0007359)4.24120695
16Pancreatic cysts (HP:0001737)4.11222046
17Pendular nystagmus (HP:0012043)4.09721730
18Pancreatic fibrosis (HP:0100732)3.89011930
19Abolished electroretinogram (ERG) (HP:0000550)3.88874597
20Abnormality of midbrain morphology (HP:0002418)3.65389315
21Molar tooth sign on MRI (HP:0002419)3.65389315
22True hermaphroditism (HP:0010459)3.63744936
23Nephronophthisis (HP:0000090)3.53073476
24Febrile seizures (HP:0002373)3.43509404
25Type II diabetes mellitus (HP:0005978)3.43306997
26* Photophobia (HP:0000613)3.41575338
27Annular pancreas (HP:0001734)3.37730813
28Resting tremor (HP:0002322)3.37193593
29Epileptic encephalopathy (HP:0200134)3.36423989
30Torticollis (HP:0000473)3.34579085
31Severe visual impairment (HP:0001141)3.28323144
32Poor eye contact (HP:0000817)3.16435061
33Macular degeneration (HP:0000608)3.15887822
34Visual hallucinations (HP:0002367)3.11514300
35Dysdiadochokinesis (HP:0002075)3.05655117
36Anxiety (HP:0000739)3.02934007
37Broad-based gait (HP:0002136)3.02634115
38Choroideremia (HP:0001139)3.00829998
39Prolonged QT interval (HP:0001657)2.98440310
40Type II lissencephaly (HP:0007260)2.96312084
41Abnormality of the renal cortex (HP:0011035)2.92327722
42Action tremor (HP:0002345)2.91945303
43Depression (HP:0000716)2.87877746
44Abnormality of the renal medulla (HP:0100957)2.86174515
45Methylmalonic acidemia (HP:0002912)2.83275769
46Posterior subcapsular cataract (HP:0007787)2.83148213
47Gaze-evoked nystagmus (HP:0000640)2.82354415
48Focal dystonia (HP:0004373)2.77730220
49Retinitis pigmentosa (HP:0000510)2.77403310
50Abnormal social behavior (HP:0012433)2.76516180
51Impaired social interactions (HP:0000735)2.76516180
52Craniofacial dystonia (HP:0012179)2.74620649
53Large for gestational age (HP:0001520)2.72703006
54Impaired vibration sensation in the lower limbs (HP:0002166)2.70044902
55Ankle clonus (HP:0011448)2.69813990
56Increased corneal curvature (HP:0100692)2.67874226
57Keratoconus (HP:0000563)2.67874226
58Urinary bladder sphincter dysfunction (HP:0002839)2.67744699
59Vitreoretinal degeneration (HP:0000655)2.64241444
60Constricted visual fields (HP:0001133)2.61774508
61Abnormal EKG (HP:0003115)2.61060469
62Acute necrotizing encephalopathy (HP:0006965)2.59858160
63Generalized tonic-clonic seizures (HP:0002069)2.58039858
64Progressive cerebellar ataxia (HP:0002073)2.56370996
65Progressive macrocephaly (HP:0004481)2.56130616
66Polydipsia (HP:0001959)2.54360140
67Abnormal drinking behavior (HP:0030082)2.54360140
68Hypothermia (HP:0002045)2.50846868
69Ankyloglossia (HP:0010296)2.50496554
70Cone-rod dystrophy (HP:0000548)2.48638195
71Decreased electroretinogram (ERG) amplitude (HP:0000654)2.48005822
72Truncal ataxia (HP:0002078)2.46125148
73Stereotypic behavior (HP:0000733)2.44583720
74Tubular atrophy (HP:0000092)2.41571758
75Ketoacidosis (HP:0001993)2.41520730
76Cystic liver disease (HP:0006706)2.40681793
77Lower limb amyotrophy (HP:0007210)2.38966644
783-Methylglutaconic aciduria (HP:0003535)2.38218760
79Progressive inability to walk (HP:0002505)2.37226377
80Mitochondrial inheritance (HP:0001427)2.36856437
81Methylmalonic aciduria (HP:0012120)2.36542599
82Scanning speech (HP:0002168)2.35838898
83Furrowed tongue (HP:0000221)2.35602968
84Sclerocornea (HP:0000647)2.34225690
85Postural instability (HP:0002172)2.34189274
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.33977607
87Retinal atrophy (HP:0001105)2.33581130
88Acute encephalopathy (HP:0006846)2.32212814
89Intestinal atresia (HP:0011100)2.32194788
90Renal cortical cysts (HP:0000803)2.30839799
91Hyperinsulinemic hypoglycemia (HP:0000825)2.29972024
92Increased CSF lactate (HP:0002490)2.26601621
93Optic nerve hypoplasia (HP:0000609)2.23373920
94Gait imbalance (HP:0002141)2.23231119
95Abnormality of vitamin B metabolism (HP:0004340)2.21900970
96Absence seizures (HP:0002121)2.21487708
97Chronic hepatic failure (HP:0100626)2.20088035
98Inability to walk (HP:0002540)2.19710706
99Anencephaly (HP:0002323)2.19677930
100Papilledema (HP:0001085)2.18555826
101Dysmetric saccades (HP:0000641)2.17715316
102Agitation (HP:0000713)2.17459249
103Pointed chin (HP:0000307)2.17364694
104Hemiparesis (HP:0001269)2.16257215
105Dysmetria (HP:0001310)2.14629941
106Male pseudohermaphroditism (HP:0000037)2.14229400
107Lissencephaly (HP:0001339)2.14109370
108Aplasia/Hypoplasia of the fovea (HP:0008060)2.11480619
109Hypoplasia of the fovea (HP:0007750)2.11480619
110Congenital primary aphakia (HP:0007707)2.11309075
111Abnormal mitochondria in muscle tissue (HP:0008316)2.11296323
112Progressive visual loss (HP:0000529)2.11192999
113Hypoglycemic seizures (HP:0002173)2.10462378
114Dialeptic seizures (HP:0011146)2.09582718
115Impaired smooth pursuit (HP:0007772)2.08872862
116Abnormality of alanine metabolism (HP:0010916)2.08328812
117Hyperalaninemia (HP:0003348)2.08328812
118Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08328812
119Hypoglycemic coma (HP:0001325)2.06940923
120Bile duct proliferation (HP:0001408)2.06511877
121Abnormal biliary tract physiology (HP:0012439)2.06511877
122Aplasia/Hypoplasia of the tibia (HP:0005772)2.05448132
123Abnormality of the labia minora (HP:0012880)2.04824388
124Limb hypertonia (HP:0002509)2.04435208
125Genetic anticipation (HP:0003743)2.02336605
126Genital tract atresia (HP:0001827)2.01423188
127Distal lower limb amyotrophy (HP:0008944)2.00424432
128Ketosis (HP:0001946)1.98922202
129Polyuria (HP:0000103)1.98539102
130Aplasia/hypoplasia of the uterus (HP:0008684)1.96484284
131Polygenic inheritance (HP:0010982)1.96359629
132Vaginal atresia (HP:0000148)1.95341973
133Impaired vibratory sensation (HP:0002495)1.94571414
134Bradykinesia (HP:0002067)1.93515856
135Congenital, generalized hypertrichosis (HP:0004540)1.93419772
136Abnormality of the fovea (HP:0000493)1.92991447
137Congenital hepatic fibrosis (HP:0002612)1.92278237
138Oligodactyly (hands) (HP:0001180)1.91178417
139Hepatic necrosis (HP:0002605)1.90913595
140Nephrogenic diabetes insipidus (HP:0009806)1.90828107
141Urinary urgency (HP:0000012)1.90712943
142Hypomagnesemia (HP:0002917)1.90436569
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.90061806
144Congenital sensorineural hearing impairment (HP:0008527)1.88177838
145Thyroiditis (HP:0100646)1.87991372
146Intention tremor (HP:0002080)1.87649383
147Septo-optic dysplasia (HP:0100842)1.87046556
148Abnormal eating behavior (HP:0100738)1.86793997
149Hepatocellular necrosis (HP:0001404)1.86002922
150Spastic gait (HP:0002064)1.85867397
151Limb dystonia (HP:0002451)1.84323537
152Atrioventricular block (HP:0001678)1.83468919
153Hyperventilation (HP:0002883)1.83441857
154Cerebellar dysplasia (HP:0007033)1.83321457
155Atonic seizures (HP:0010819)1.83163527
156Medial flaring of the eyebrow (HP:0010747)1.82208666
157Abnormality of ocular smooth pursuit (HP:0000617)1.81731296
158Lipid accumulation in hepatocytes (HP:0006561)1.81539340
159Abnormal ciliary motility (HP:0012262)1.80533391
160Supranuclear gaze palsy (HP:0000605)1.79755243
161Short tibia (HP:0005736)1.78849423
162Subcapsular cataract (HP:0000523)1.78334535
163Abnormal albumin level (HP:0012116)1.78233480
164Hypoalbuminemia (HP:0003073)1.78233480
165Abnormality of urine glucose concentration (HP:0011016)1.78147656
166Glycosuria (HP:0003076)1.78147656
167Abnormal respiratory motile cilium morphology (HP:0005938)1.77980472
168Abnormal respiratory epithelium morphology (HP:0012253)1.77980472
169Optic disc pallor (HP:0000543)1.77894692
170Acute lymphatic leukemia (HP:0006721)1.77155746
171Abnormality of oral frenula (HP:0000190)1.77011338
172Polyphagia (HP:0002591)1.75995127
173Severe muscular hypotonia (HP:0006829)1.74097273
174Wide nasal bridge (HP:0000431)1.72884109
175Abnormality of the vitamin B12 metabolism (HP:0004341)1.71979423
176Abnormality of the pons (HP:0007361)1.71575040
177Obsessive-compulsive behavior (HP:0000722)1.66919871
178Horizontal nystagmus (HP:0000666)1.65115209
179Mutism (HP:0002300)1.64338083
180Atrial fibrillation (HP:0005110)1.64122515
181Heart block (HP:0012722)1.63536935
182Megalencephaly (HP:0001355)1.63003751

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.59082740
2FRK5.85204035
3NTRK34.07343941
4ZAK2.91066225
5PRKD32.79228605
6MAP3K92.77824514
7BMPR1B2.54786300
8TLK12.53968378
9GRK12.53837558
10DAPK22.47783505
11MAP4K22.47009480
12NUAK12.46756902
13RIPK42.39886022
14CAMKK12.36535750
15KSR22.17261397
16FES2.06728423
17FGFR22.01663183
18TNIK1.99836632
19MST41.87044203
20SIK21.85500830
21MINK11.84179509
22MAP3K131.83530807
23TAOK31.83506160
24ACVR1B1.81821716
25PINK11.80761402
26MAP3K41.80152404
27NTRK21.73456369
28WNK41.70731338
29PRPF4B1.64508571
30MARK11.59428044
31KSR11.54624154
32CDK51.54510704
33SGK21.52994937
34CAMKK21.49274707
35MAP2K71.48762142
36MAP3K21.48727148
37PAK61.47222765
38ARAF1.45688615
39SGK2231.43807787
40SGK4941.43807787
41TAOK11.39489149
42BMPR21.32662375
43SGK31.31702797
44NTRK11.29263658
45DAPK11.28682846
46PHKG11.28080142
47PHKG21.28080142
48PRKCH1.25482587
49PAK31.23780212
50STK381.23491842
51NLK1.22968745
52TXK1.20902882
53VRK11.16044317
54NEK61.15209015
55MKNK21.14441481
56TRIM281.14419457
57CSNK1G11.04414854
58DYRK21.03516675
59TNK21.02851715
60SIK30.99985721
61SGK10.99438859
62OBSCN0.97455175
63TYRO30.94607211
64TIE10.94189225
65OXSR10.93305709
66STK38L0.93041114
67STK160.92869990
68STK390.92522037
69CSNK1G20.91980422
70RAF10.89025550
71CSNK1G30.87134737
72MARK20.86535635
73PLK30.85854431
74MAPK130.85055742
75PRKCG0.84285175
76CAMK10.81027205
77PNCK0.80757712
78STK30.80205863
79PRKD20.77023563
80STK110.76603210
81BCKDK0.76432658
82MAP2K40.75078389
83UHMK10.74693386
84MAP2K60.73596033
85NME10.73166109
86MAP3K10.72642730
87WNK10.71899922
88CAMK2A0.71750671
89INSRR0.70786156
90CASK0.69073719
91NEK20.68107940
92PRKCQ0.67013690
93PRKCZ0.65835175
94PDPK10.64939031
95RPS6KA30.64508482
96EPHA30.64288360
97CDK180.64183017
98BRSK20.63299811
99ALK0.63012163
100MAPK150.62927010
101IRAK20.62780530
102PDK10.61994538
103TGFBR10.61212166
104RPS6KA50.60970095
105CDK150.60843370
106GRK50.59479610
107CAMK40.58284038
108PKN10.58017833
109CAMK2B0.57529361
110CSNK1A1L0.57507957
111RET0.56696211
112IKBKB0.55857230
113VRK20.55813957
114PRKCI0.55741896
115CDC42BPA0.55440972
116HIPK20.55074843
117CDK140.54184909
118MAPK70.54152089
119NEK10.54053459
120AKT30.53998167
121PRKCB0.53628507
122TEC0.51978446
123CDK11A0.51620768
124MAPK100.50743551
125FYN0.49956792
126RPS6KA20.46668800
127IRAK10.46650548
128CAMK2D0.45920386
129GRK60.45289763
130PLK20.44957804
131PRKCE0.44500297
132FER0.44110512
133GRK70.44091853
134ADRBK20.43633948
135DYRK1A0.42750816
136MAP3K120.42647627
137ERBB40.41377316
138ADRBK10.40413936
139PRKACG0.40206294
140RIPK10.40004463
141PTK2B0.39978017
142MAP2K10.39808909
143BRAF0.39791584
144MAP2K20.39322801
145PIK3CA0.38632427
146PLK10.38275369
147PRKACA0.36908414
148ERBB30.36104675
149ERBB20.35317173
150PRKG10.35189110
151WNK30.35072075
152CSNK1A10.34613390
153MARK30.34258607
154GSK3B0.33629385
155PRKAA10.33273341
156PRKAA20.33025200
157MAPK80.32981697
158MUSK0.32514979
159PRKCA0.32078987
160HCK0.31908080
161TAF10.30648518
162CSNK1D0.29098127
163CHUK0.26243948
164EIF2AK30.25066321
165CDK30.24877548

Predicted pathways (KEGG)

RankGene SetZ-score
1* Phototransduction_Homo sapiens_hsa047446.59796806
2Olfactory transduction_Homo sapiens_hsa047403.84590716
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.62719627
4Morphine addiction_Homo sapiens_hsa050322.88379042
5GABAergic synapse_Homo sapiens_hsa047272.72869148
6Synaptic vesicle cycle_Homo sapiens_hsa047212.71482301
7Oxidative phosphorylation_Homo sapiens_hsa001902.70181704
8Circadian entrainment_Homo sapiens_hsa047132.63752447
9Nicotine addiction_Homo sapiens_hsa050332.54723720
10Amphetamine addiction_Homo sapiens_hsa050312.45104618
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.37950255
12Glutamatergic synapse_Homo sapiens_hsa047242.36335329
13Dopaminergic synapse_Homo sapiens_hsa047282.33019215
14Protein export_Homo sapiens_hsa030602.27907091
15Cholinergic synapse_Homo sapiens_hsa047252.25901366
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25408418
17Linoleic acid metabolism_Homo sapiens_hsa005912.24323001
18* Cocaine addiction_Homo sapiens_hsa050302.19731925
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15529945
20Butanoate metabolism_Homo sapiens_hsa006502.15518281
21Long-term potentiation_Homo sapiens_hsa047202.13673305
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07781677
23Parkinsons disease_Homo sapiens_hsa050122.02554679
24Selenocompound metabolism_Homo sapiens_hsa004501.86127155
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84148333
26Insulin secretion_Homo sapiens_hsa049111.83220692
27Tryptophan metabolism_Homo sapiens_hsa003801.78739807
28Renin secretion_Homo sapiens_hsa049241.78091822
29Caffeine metabolism_Homo sapiens_hsa002321.75825060
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74742873
31Salivary secretion_Homo sapiens_hsa049701.74409596
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70089621
33Ether lipid metabolism_Homo sapiens_hsa005651.66392518
34Serotonergic synapse_Homo sapiens_hsa047261.65537169
35Oxytocin signaling pathway_Homo sapiens_hsa049211.60562440
36RNA polymerase_Homo sapiens_hsa030201.55966298
37Calcium signaling pathway_Homo sapiens_hsa040201.53871848
38Gastric acid secretion_Homo sapiens_hsa049711.51051849
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49249591
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46251732
41Homologous recombination_Homo sapiens_hsa034401.42736768
42Propanoate metabolism_Homo sapiens_hsa006401.41774285
43Alzheimers disease_Homo sapiens_hsa050101.40570966
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.35925407
45cAMP signaling pathway_Homo sapiens_hsa040241.35748369
46Taste transduction_Homo sapiens_hsa047421.34575552
47Fanconi anemia pathway_Homo sapiens_hsa034601.33189231
48Sulfur metabolism_Homo sapiens_hsa009201.31887777
49Basal transcription factors_Homo sapiens_hsa030221.29533826
50Peroxisome_Homo sapiens_hsa041461.29002160
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28793146
52Gap junction_Homo sapiens_hsa045401.26364314
53Chemical carcinogenesis_Homo sapiens_hsa052041.24069943
54Huntingtons disease_Homo sapiens_hsa050161.21805005
55Nitrogen metabolism_Homo sapiens_hsa009101.21781394
56GnRH signaling pathway_Homo sapiens_hsa049121.20672002
57Long-term depression_Homo sapiens_hsa047301.19894666
58Regulation of autophagy_Homo sapiens_hsa041401.14879194
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13455095
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13032104
61Arachidonic acid metabolism_Homo sapiens_hsa005901.12978128
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12187889
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11029606
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.08719576
65RNA degradation_Homo sapiens_hsa030181.07780246
66Retinol metabolism_Homo sapiens_hsa008301.07298572
67cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06919940
68One carbon pool by folate_Homo sapiens_hsa006701.05890389
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05408334
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04379177
71Type II diabetes mellitus_Homo sapiens_hsa049301.03669151
72Vitamin B6 metabolism_Homo sapiens_hsa007501.00494457
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95855209
74beta-Alanine metabolism_Homo sapiens_hsa004100.94613928
75Folate biosynthesis_Homo sapiens_hsa007900.92373313
76Glioma_Homo sapiens_hsa052140.91665174
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90943148
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90374837
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.89964464
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89561190
81Type I diabetes mellitus_Homo sapiens_hsa049400.89419956
82Alcoholism_Homo sapiens_hsa050340.88220369
83Proteasome_Homo sapiens_hsa030500.87433060
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85611986
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84999580
86Circadian rhythm_Homo sapiens_hsa047100.83952223
87ABC transporters_Homo sapiens_hsa020100.82983635
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.82351987
89Dilated cardiomyopathy_Homo sapiens_hsa054140.77562965
90Purine metabolism_Homo sapiens_hsa002300.77076820
91Melanogenesis_Homo sapiens_hsa049160.77071496
92Fatty acid elongation_Homo sapiens_hsa000620.75675892
93Non-small cell lung cancer_Homo sapiens_hsa052230.75374661
94ErbB signaling pathway_Homo sapiens_hsa040120.74141913
95Estrogen signaling pathway_Homo sapiens_hsa049150.73913620
96Fat digestion and absorption_Homo sapiens_hsa049750.71349734
97Vitamin digestion and absorption_Homo sapiens_hsa049770.71269915
98Metabolic pathways_Homo sapiens_hsa011000.71042695
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69736560
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69623971
101Pancreatic secretion_Homo sapiens_hsa049720.69604757
102Chemokine signaling pathway_Homo sapiens_hsa040620.68176737
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68015944
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68013065
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66097900
106Glycerolipid metabolism_Homo sapiens_hsa005610.66063082
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65208838
108Collecting duct acid secretion_Homo sapiens_hsa049660.64725270
109MAPK signaling pathway_Homo sapiens_hsa040100.64030196
110Rap1 signaling pathway_Homo sapiens_hsa040150.63251548
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62984552
112Fatty acid degradation_Homo sapiens_hsa000710.62633075
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62001192
114Thyroid hormone synthesis_Homo sapiens_hsa049180.61578712
115Choline metabolism in cancer_Homo sapiens_hsa052310.59958833
116Axon guidance_Homo sapiens_hsa043600.59739830
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56423221
118Oocyte meiosis_Homo sapiens_hsa041140.55309627
119Cardiac muscle contraction_Homo sapiens_hsa042600.54699040
120Inositol phosphate metabolism_Homo sapiens_hsa005620.54125073
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52709049
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.52651574
123Ras signaling pathway_Homo sapiens_hsa040140.52486204
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52270993
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51973310
126Dorso-ventral axis formation_Homo sapiens_hsa043200.50917036
127Primary immunodeficiency_Homo sapiens_hsa053400.50532490
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50194259
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50155534
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49805609
131mTOR signaling pathway_Homo sapiens_hsa041500.49732517
132Mineral absorption_Homo sapiens_hsa049780.49582824
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.47154689
134Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46521440
135Ovarian steroidogenesis_Homo sapiens_hsa049130.44917734
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44416024
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44236190
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.42812955
139Histidine metabolism_Homo sapiens_hsa003400.41731397
140Glucagon signaling pathway_Homo sapiens_hsa049220.41548448
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41430380
142Vibrio cholerae infection_Homo sapiens_hsa051100.41305852
143Pyrimidine metabolism_Homo sapiens_hsa002400.40191189
144African trypanosomiasis_Homo sapiens_hsa051430.39177024
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.37769311
146Hedgehog signaling pathway_Homo sapiens_hsa043400.37513228
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36660076
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36656346
149Systemic lupus erythematosus_Homo sapiens_hsa053220.36584563
150VEGF signaling pathway_Homo sapiens_hsa043700.36447549
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36125188
152Endometrial cancer_Homo sapiens_hsa052130.36118127
153Endocytosis_Homo sapiens_hsa041440.33621105
154Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33126243
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.30676832
156Platelet activation_Homo sapiens_hsa046110.30257838
157Bile secretion_Homo sapiens_hsa049760.29173614
158Prion diseases_Homo sapiens_hsa050200.28185854
159Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28008442
160Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26324641
161Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26234452
162Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25048937
163Wnt signaling pathway_Homo sapiens_hsa043100.23434766
164Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23398547
165Insulin signaling pathway_Homo sapiens_hsa049100.21690357
166Renal cell carcinoma_Homo sapiens_hsa052110.20647175
167Prolactin signaling pathway_Homo sapiens_hsa049170.20304107

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