RHAG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is erythrocyte-specific and is thought to be part of a membrane channel that transports ammonium and carbon dioxide across the blood cell membrane. The encoded protein appears to interact with Rh blood group antigens and Rh30 polypeptides. Defects in this gene are a cause of regulator type Rh-null hemolytic anemia (RHN), or Rh-deficiency syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tetrapyrrole biosynthetic process (GO:0033014)9.87613690
2oxygen transport (GO:0015671)9.83728581
3heme metabolic process (GO:0042168)9.25565098
4porphyrin-containing compound metabolic process (GO:0006778)8.70058768
5* gas transport (GO:0015669)8.27492335
6erythrocyte maturation (GO:0043249)8.08557396
7tetrapyrrole metabolic process (GO:0033013)5.70154625
8pigment biosynthetic process (GO:0046148)5.59079406
9hemoglobin metabolic process (GO:0020027)5.44580326
10nuclear pore complex assembly (GO:0051292)5.19859223
11response to methylmercury (GO:0051597)5.09807436
12negative regulation of erythrocyte differentiation (GO:0045647)5.04538824
13response to lead ion (GO:0010288)4.85081053
14DNA topological change (GO:0006265)4.83805398
15regulation of RNA export from nucleus (GO:0046831)4.81256049
16response to insecticide (GO:0017085)4.73638198
17pigment metabolic process (GO:0042440)4.68871912
18DNA replication initiation (GO:0006270)4.67325943
19telomere maintenance via semi-conservative replication (GO:0032201)4.65093073
20nuclear pore organization (GO:0006999)4.64454523
21DNA replication checkpoint (GO:0000076)4.53658468
22DNA strand elongation involved in DNA replication (GO:0006271)4.41449139
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.41111820
24definitive hemopoiesis (GO:0060216)4.31339580
25DNA strand elongation (GO:0022616)4.25668606
26erythrocyte differentiation (GO:0030218)4.23780961
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.13872774
28CENP-A containing nucleosome assembly (GO:0034080)4.11249230
29regulation of translational fidelity (GO:0006450)4.09363104
30* erythrocyte development (GO:0048821)4.04748567
31kinetochore organization (GO:0051383)4.04376665
32protein-cofactor linkage (GO:0018065)3.99276006
33telomere maintenance via recombination (GO:0000722)3.97689960
34regulation of nucleobase-containing compound transport (GO:0032239)3.94615122
35regulation of histone H3-K4 methylation (GO:0051569)3.88189169
36pore complex assembly (GO:0046931)3.87736161
37iron ion import (GO:0097286)3.85349946
38chromatin remodeling at centromere (GO:0031055)3.84667475
39DNA deamination (GO:0045006)3.81335796
40kinetochore assembly (GO:0051382)3.69290018
41proteasome assembly (GO:0043248)3.68468442
42proline biosynthetic process (GO:0006561)3.67971251
43deoxyribonucleotide biosynthetic process (GO:0009263)3.64672103
44regulation of histone H3-K27 methylation (GO:0061085)3.63377755
45mitotic recombination (GO:0006312)3.61799227
46regulation of erythrocyte differentiation (GO:0045646)3.58647267
47regulation of histone H3-K9 methylation (GO:0051570)3.58083003
48DNA replication-independent nucleosome organization (GO:0034724)3.57051855
49DNA replication-independent nucleosome assembly (GO:0006336)3.57051855
50ribosomal small subunit assembly (GO:0000028)3.52364674
51protein autoprocessing (GO:0016540)3.51420211
52regulation of response to osmotic stress (GO:0047484)3.51392596
53membrane disassembly (GO:0030397)3.46025847
54nuclear envelope disassembly (GO:0051081)3.46025847
55positive regulation of megakaryocyte differentiation (GO:0045654)3.43476080
56homocysteine metabolic process (GO:0050667)3.41736583
57regulation of DNA endoreduplication (GO:0032875)3.37184097
58mitotic sister chromatid segregation (GO:0000070)3.35747821
59telomere maintenance via telomere lengthening (GO:0010833)3.32638859
60negative regulation of histone methylation (GO:0031061)3.31900921
61meiotic chromosome segregation (GO:0045132)3.30536412
62protein localization to chromosome, centromeric region (GO:0071459)3.26262374
63formation of translation preinitiation complex (GO:0001731)3.25832130
64positive regulation of granulocyte differentiation (GO:0030854)3.20494088
65attachment of spindle microtubules to kinetochore (GO:0008608)3.17937570
66positive regulation of erythrocyte differentiation (GO:0045648)3.17590708
67DNA replication-dependent nucleosome assembly (GO:0006335)3.16103991
68DNA replication-dependent nucleosome organization (GO:0034723)3.16103991
69embryonic hemopoiesis (GO:0035162)3.10966319
70oxidative phosphorylation (GO:0006119)3.10688631
71DNA unwinding involved in DNA replication (GO:0006268)3.10244944
72metallo-sulfur cluster assembly (GO:0031163)3.07870065
73iron-sulfur cluster assembly (GO:0016226)3.07870065
742-deoxyribonucleotide biosynthetic process (GO:0009265)3.07704057
75deoxyribose phosphate biosynthetic process (GO:0046385)3.07704057
76synapsis (GO:0007129)3.06540499
77nucleotide-excision repair, DNA gap filling (GO:0006297)3.05907459
78histone exchange (GO:0043486)3.03469760
79cofactor biosynthetic process (GO:0051188)3.01966983
80chromosome segregation (GO:0007059)2.95949695
81megakaryocyte development (GO:0035855)2.95718093
82purine nucleobase biosynthetic process (GO:0009113)2.95630403
83hematopoietic stem cell differentiation (GO:0060218)2.95577605
84positive regulation of histone methylation (GO:0031062)2.94395672
85granulocyte differentiation (GO:0030851)2.93718831
86cellular response to thyroid hormone stimulus (GO:0097067)2.93606095
87protein localization to kinetochore (GO:0034501)2.93248259
88viral transcription (GO:0019083)2.93012048
89folic acid-containing compound biosynthetic process (GO:0009396)2.92720780
90resolution of meiotic recombination intermediates (GO:0000712)2.92189168
91microtubule depolymerization (GO:0007019)2.90878294
92sister chromatid segregation (GO:0000819)2.90685174
93diterpenoid biosynthetic process (GO:0016102)2.90229787
94regulation of histone methylation (GO:0031060)2.89548113
95response to arsenic-containing substance (GO:0046685)2.89116696
96nucleosome assembly (GO:0006334)2.84283057
97translational termination (GO:0006415)2.83769205
98tetrahydrofolate metabolic process (GO:0046653)2.83736239
99tRNA aminoacylation for protein translation (GO:0006418)2.81464506
100protein export from nucleus (GO:0006611)2.79625384
101positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.79177358
102DNA catabolic process, exonucleolytic (GO:0000738)2.76642112
103positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.74771296
104oxaloacetate metabolic process (GO:0006107)2.74619736
105regulation of mitotic spindle organization (GO:0060236)2.74155218
106chromatin assembly or disassembly (GO:0006333)2.73632130
107response to thyroid hormone (GO:0097066)2.70702048
108tRNA aminoacylation (GO:0043039)2.70000551
109amino acid activation (GO:0043038)2.70000551
110IMP biosynthetic process (GO:0006188)2.67438144
111purine-containing compound salvage (GO:0043101)2.67432184
112chromosome condensation (GO:0030261)2.67377394
113regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.66867350
114protein-DNA complex assembly (GO:0065004)2.66634469
115negative regulation of potassium ion transmembrane transport (GO:1901380)2.66591121
116mitotic chromosome condensation (GO:0007076)2.65538146
117terpenoid biosynthetic process (GO:0016114)2.65443503
118positive regulation of insulin receptor signaling pathway (GO:0046628)2.65385510
119very-low-density lipoprotein particle assembly (GO:0034379)2.63463273
120* myeloid cell development (GO:0061515)2.62046252
121positive regulation of chromosome segregation (GO:0051984)2.61607133
122negative regulation of bone mineralization (GO:0030502)2.61082235
123nucleobase biosynthetic process (GO:0046112)2.60229633
124potassium ion export (GO:0071435)2.58179700
125pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.58014592
126translational elongation (GO:0006414)2.56633202
127negative regulation of viral entry into host cell (GO:0046597)2.54947956
128telomere maintenance (GO:0000723)2.54630562
129telomere organization (GO:0032200)2.54121804
130SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.52484715
131mitotic nuclear envelope disassembly (GO:0007077)2.51611066
132tRNA methylation (GO:0030488)2.50686610
133maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.49864423
134DNA double-strand break processing (GO:0000729)2.49860455
135transcription-coupled nucleotide-excision repair (GO:0006283)2.48238740
136hydrogen peroxide catabolic process (GO:0042744)2.47526761
137response to folic acid (GO:0051593)2.47460654
138cotranslational protein targeting to membrane (GO:0006613)2.46737718
139platelet formation (GO:0030220)2.46220098
140protein targeting to ER (GO:0045047)2.45042577
141anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.43782841
142deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.43695262
143DNA synthesis involved in DNA repair (GO:0000731)2.43533974
144spliceosomal complex assembly (GO:0000245)2.43416261
145mitotic metaphase plate congression (GO:0007080)2.42450315
146centriole assembly (GO:0098534)2.41941691
147cell cycle G1/S phase transition (GO:0044843)2.41455274
148G1/S transition of mitotic cell cycle (GO:0000082)2.41455274
149protoporphyrinogen IX metabolic process (GO:0046501)16.1837886
150protoporphyrinogen IX biosynthetic process (GO:0006782)15.6605656
151heme biosynthetic process (GO:0006783)11.7065546
152porphyrin-containing compound biosynthetic process (GO:0006779)10.9430610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.28783261
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.64107890
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.30180678
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.12653959
5GATA1_22025678_ChIP-Seq_K562_Human3.79447911
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23107077
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22977238
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.08077715
9* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.82414194
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.76754595
11NCOR1_26117541_ChIP-Seq_K562_Human2.69908931
12KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.66260568
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.59966465
14* GATA1_19941827_ChIP-Seq_MEL_Mouse2.56734655
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52603572
16GATA1_19941826_ChIP-Seq_K562_Human2.51848600
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.51296550
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50228999
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.40951572
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38568790
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30473350
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27908957
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25086045
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24912102
25VDR_23849224_ChIP-Seq_CD4+_Human2.18551887
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14495216
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13516430
28* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.10481315
29E2F1_21310950_ChIP-Seq_MCF-7_Human2.08711532
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03126508
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02231541
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99368275
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.97581135
34* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.86058441
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84945612
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83913558
37* SCL_19346495_ChIP-Seq_HPC-7_Human1.83711282
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83375442
39DCP1A_22483619_ChIP-Seq_HELA_Human1.82754645
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82668983
41FOXP3_21729870_ChIP-Seq_TREG_Human1.81786590
42AR_21909140_ChIP-Seq_LNCAP_Human1.78797359
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76590547
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73551899
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73314840
46XRN2_22483619_ChIP-Seq_HELA_Human1.70155028
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66855792
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65930360
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63392462
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60058715
51ZNF263_19887448_ChIP-Seq_K562_Human1.57471359
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52155821
53ELK1_19687146_ChIP-ChIP_HELA_Human1.51996993
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51150566
55GABP_19822575_ChIP-Seq_HepG2_Human1.49675451
56TTF2_22483619_ChIP-Seq_HELA_Human1.45942166
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44319985
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39342186
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.37283340
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34231794
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29386113
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28992914
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27071465
64* GATA2_19941826_ChIP-Seq_K562_Human1.25360634
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23198880
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21881226
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19690575
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19430738
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18566834
70SPI1_23127762_ChIP-Seq_K562_Human1.17975909
71CIITA_25753668_ChIP-Seq_RAJI_Human1.16320826
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15486944
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14597659
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13897912
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12750410
76KDM5A_27292631_Chip-Seq_BREAST_Human1.12524377
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11963136
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11462801
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10673248
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09215917
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06948726
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03746100
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03065628
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01517983
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01074880
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00536323
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.99924931
88MYC_22102868_ChIP-Seq_BL_Human0.99336748
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98942878
90VDR_21846776_ChIP-Seq_THP-1_Human0.98183638
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97773857
92MYC_18940864_ChIP-ChIP_HL60_Human0.97265839
93TFEB_21752829_ChIP-Seq_HELA_Human0.96621494
94STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96598810
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95873757
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94351980
97* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91976479
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91332599
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90806447
100NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89389540
101RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87870134
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87091682
103TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87005174
104MAF_26560356_Chip-Seq_TH1_Human0.86315714
105* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85787253
106POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84926320
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84555445
108* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83185858
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82725030
110CHD1_26751641_Chip-Seq_LNCaP_Human0.81416308
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.81298131
112ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.79182337
113IRF1_19129219_ChIP-ChIP_H3396_Human0.78388130
114GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77926629
115EGR1_23403033_ChIP-Seq_LIVER_Mouse0.77142272
116RUNX1_22412390_ChIP-Seq_EML_Mouse0.76510812
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74539852
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74222737
119SPI1_23547873_ChIP-Seq_NB4_Human0.73145535
120EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.72181566
121FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70476838
122GATA4_21415370_ChIP-Seq_HL-1_Mouse0.70282183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.72319340
2MP0010094_abnormal_chromosome_stability3.25444579
3MP0003693_abnormal_embryo_hatching2.90834823
4MP0008057_abnormal_DNA_replication2.69892855
5MP0001545_abnormal_hematopoietic_system2.57984848
6MP0005397_hematopoietic_system_phenotyp2.57984848
7MP0003077_abnormal_cell_cycle2.57294552
8MP0006054_spinal_hemorrhage2.54973444
9MP0008058_abnormal_DNA_repair2.48176640
10MP0004957_abnormal_blastocyst_morpholog2.12362054
11MP0002396_abnormal_hematopoietic_system2.06069737
12MP0004147_increased_porphyrin_level10.7935825
13MP0003656_abnormal_erythrocyte_physiolo10.3886566
14MP0005636_abnormal_mineral_homeostasis1.96922724
15MP0002132_abnormal_respiratory_system1.93979963
16MP0005451_abnormal_body_composition1.88849850
17MP0000490_abnormal_crypts_of1.82523031
18MP0003186_abnormal_redox_activity1.64855963
19MP0009278_abnormal_bone_marrow1.60772685
20MP0006036_abnormal_mitochondrial_physio1.55740646
21MP0009333_abnormal_splenocyte_physiolog1.48246343
22MP0004145_abnormal_muscle_electrophysio1.47947481
23MP0002398_abnormal_bone_marrow1.46940647
24MP0001529_abnormal_vocalization1.43135341
25MP0000372_irregular_coat_pigmentation1.42028236
26MP0005083_abnormal_biliary_tract1.41749607
27MP0008007_abnormal_cellular_replicative1.34207383
28MP0005171_absent_coat_pigmentation1.29614169
29MP0008932_abnormal_embryonic_tissue1.25912325
30MP0000689_abnormal_spleen_morphology1.24261846
31MP0002722_abnormal_immune_system1.24145577
32MP0002102_abnormal_ear_morphology1.22156810
33MP0003806_abnormal_nucleotide_metabolis1.17170584
34MP0001672_abnormal_embryogenesis/_devel1.15622200
35MP0005380_embryogenesis_phenotype1.15622200
36MP0000678_abnormal_parathyroid_gland1.14527599
37MP0001661_extended_life_span1.13227109
38MP0002429_abnormal_blood_cell1.12525223
39MP0000313_abnormal_cell_death1.12511551
40MP0003984_embryonic_growth_retardation1.10731730
41MP0008775_abnormal_heart_ventricle1.09733263
42MP0000350_abnormal_cell_proliferation1.06569075
43MP0002088_abnormal_embryonic_growth/wei1.06230821
44MP0003786_premature_aging1.06062931
45MP0006292_abnormal_olfactory_placode1.05378192
46MP0005671_abnormal_response_to1.04344141
47MP0008260_abnormal_autophagy1.02230457
48MP0010307_abnormal_tumor_latency0.98021038
49MP0008789_abnormal_olfactory_epithelium0.96904380
50MP0003890_abnormal_embryonic-extraembry0.96703467
51MP0008872_abnormal_physiological_respon0.96088328
52MP0002019_abnormal_tumor_incidence0.95063427
53MP0005464_abnormal_platelet_physiology0.94827568
54MP0004215_abnormal_myocardial_fiber0.93645399
55MP0004264_abnormal_extraembryonic_tissu0.93361578
56MP0005076_abnormal_cell_differentiation0.93271623
57MP0000685_abnormal_immune_system0.92968957
58MP0009764_decreased_sensitivity_to0.92069467
59MP0002095_abnormal_skin_pigmentation0.90347739
60MP0001727_abnormal_embryo_implantation0.89407325
61MP0000609_abnormal_liver_physiology0.87870041
62MP0000749_muscle_degeneration0.85788352
63MP0002877_abnormal_melanocyte_morpholog0.85740858
64MP0000703_abnormal_thymus_morphology0.85720813
65MP0005499_abnormal_olfactory_system0.81358094
66MP0005394_taste/olfaction_phenotype0.81358094
67MP0009931_abnormal_skin_appearance0.79945039
68MP0003718_maternal_effect0.78462430
69MP0005501_abnormal_skin_physiology0.78102837
70MP0001764_abnormal_homeostasis0.78093165
71MP0004808_abnormal_hematopoietic_stem0.74069555
72MP0000598_abnormal_liver_morphology0.72002024
73MP0003221_abnormal_cardiomyocyte_apopto0.68381067
74MP0000716_abnormal_immune_system0.67411641
75MP0002080_prenatal_lethality0.67361953
76MP0002405_respiratory_system_inflammati0.66341304
77MP0008877_abnormal_DNA_methylation0.65780942
78MP0002084_abnormal_developmental_patter0.64781261
79MP0003959_abnormal_lean_body0.64642006
80MP0003698_abnormal_male_reproductive0.60713518
81MP0001730_embryonic_growth_arrest0.60202398
82MP0005075_abnormal_melanosome_morpholog0.59048141
83MP0002085_abnormal_embryonic_tissue0.58333291
84MP0006035_abnormal_mitochondrial_morpho0.58171736
85MP0003724_increased_susceptibility_to0.57841367
86MP0004233_abnormal_muscle_weight0.57572855
87MP0001243_abnormal_dermal_layer0.57555329
88MP0001881_abnormal_mammary_gland0.56791492
89MP0009697_abnormal_copulation0.56560388
90MP0000747_muscle_weakness0.55923737
91MP0002138_abnormal_hepatobiliary_system0.55763661
92MP0005025_abnormal_response_to0.55342729
93MP0003763_abnormal_thymus_physiology0.55018807
94MP0001145_abnormal_male_reproductive0.54415908
95MP0003699_abnormal_female_reproductive0.54197854
96MP0000653_abnormal_sex_gland0.54163807
97MP0001663_abnormal_digestive_system0.50952205
98MP0000358_abnormal_cell_content/0.50899532
99MP0001188_hyperpigmentation0.50873130
100MP0009765_abnormal_xenobiotic_induced0.50858694
101MP0000015_abnormal_ear_pigmentation0.48778139
102MP0001853_heart_inflammation0.48595569
103MP0008770_decreased_survivor_rate0.48578357
104MP0002420_abnormal_adaptive_immunity0.48536981
105MP0001819_abnormal_immune_cell0.47912614
106MP0002161_abnormal_fertility/fecundity0.47657969
107MP0004885_abnormal_endolymph0.47137038
108MP0005384_cellular_phenotype0.46429489
109MP0001835_abnormal_antigen_presentation0.46280152
110MP0003567_abnormal_fetal_cardiomyocyte0.46205613
111MP0001697_abnormal_embryo_size0.46088068
112MP0008469_abnormal_protein_level0.46044036
113MP0005174_abnormal_tail_pigmentation0.45209450
114MP0005410_abnormal_fertilization0.45048910
115MP0009379_abnormal_foot_pigmentation0.44424289
116MP0002210_abnormal_sex_determination0.44335529
117MP0002083_premature_death0.43597752
118MP0009703_decreased_birth_body0.43491679
119MP0001919_abnormal_reproductive_system0.42843758
120MP0005535_abnormal_body_temperature0.42766145
121MP0000266_abnormal_heart_morphology0.42225371
122MP0002452_abnormal_antigen_presenting0.42000179
123MP0005058_abnormal_lysosome_morphology0.41966985
124MP0005621_abnormal_cell_physiology0.41760145
125MP0002086_abnormal_extraembryonic_tissu0.41565116
126MP0009115_abnormal_fat_cell0.41491281
127MP0005389_reproductive_system_phenotype0.41419850
128MP0001800_abnormal_humoral_immune0.41341029
129MP0005266_abnormal_metabolism0.40654673
130MP0008995_early_reproductive_senescence0.40143927
131MP0005332_abnormal_amino_acid0.38677912
132MP0001986_abnormal_taste_sensitivity0.38529317
133MP0002269_muscular_atrophy0.38277173
134MP0002009_preneoplasia0.37985500
135MP0001929_abnormal_gametogenesis0.37972199
136MP0005000_abnormal_immune_tolerance0.37762008
137MP0009785_altered_susceptibility_to0.36868526
138MP0002938_white_spotting0.36530281
139MP0009763_increased_sensitivity_to0.36445914
140MP0000465_gastrointestinal_hemorrhage0.36403828
141MP0000858_altered_metastatic_potential0.35986306
142MP0002723_abnormal_immune_serum0.35943117

Predicted human phenotypes

RankGene SetZ-score
1* Poikilocytosis (HP:0004447)8.86437767
2Acanthocytosis (HP:0001927)7.27100888
3Abnormal hemoglobin (HP:0011902)6.93936756
4Reticulocytosis (HP:0001923)6.60959495
5Hypochromic microcytic anemia (HP:0004840)6.55101125
6Diaphragmatic weakness (HP:0009113)6.02274207
7Abnormal number of erythroid precursors (HP:0012131)5.77568898
8Abnormality of cells of the erythroid lineage (HP:0012130)5.34314935
9Abnormality of reticulocytes (HP:0004312)5.18966926
10Paralysis (HP:0003470)5.10033271
11Cholelithiasis (HP:0001081)4.91752748
12Birth length less than 3rd percentile (HP:0003561)4.49859312
13Abnormal gallbladder morphology (HP:0012437)4.42122932
14Insomnia (HP:0100785)4.27705513
15Truncus arteriosus (HP:0001660)4.21601563
16Cutaneous photosensitivity (HP:0000992)4.19199178
17Osteomalacia (HP:0002749)4.14404732
18Ileus (HP:0002595)3.96432328
19Microcytic anemia (HP:0001935)3.77945181
20Hypochromic anemia (HP:0001931)3.67120963
21Hyperthyroidism (HP:0000836)3.66344911
22* Hyperbilirubinemia (HP:0002904)3.60057937
23Abnormality of homocysteine metabolism (HP:0010919)3.46950594
24Homocystinuria (HP:0002156)3.46950594
25Increased serum ferritin (HP:0003281)3.45790781
26Petechiae (HP:0000967)3.33208449
27Abnormal gallbladder physiology (HP:0012438)3.13637824
28Cholecystitis (HP:0001082)3.13637824
29Pallor (HP:0000980)3.04093031
30Abnormality of the gallbladder (HP:0005264)3.03793892
31Abnormality of iron homeostasis (HP:0011031)2.99600809
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98954558
33Nausea (HP:0002018)2.96684729
34Chromsome breakage (HP:0040012)2.91819360
35Cortical dysplasia (HP:0002539)2.91348581
36Hyponatremia (HP:0002902)2.89475055
37Hypoparathyroidism (HP:0000829)2.86597710
38Bowel incontinence (HP:0002607)2.84121202
39Short middle phalanx of the 5th finger (HP:0004220)2.78961355
40Prolonged bleeding time (HP:0003010)2.78645689
41Abnormality of transition element cation homeostasis (HP:0011030)2.77240788
42Seborrheic dermatitis (HP:0001051)2.76582282
43Macrocytic anemia (HP:0001972)2.74771990
44Abnormal large intestine physiology (HP:0012700)2.72941902
45Reticulocytopenia (HP:0001896)2.66535694
46Hepatocellular carcinoma (HP:0001402)2.64720183
47Polycythemia (HP:0001901)2.63679723
48Ankyloglossia (HP:0010296)2.62694591
49Abnormality of sodium homeostasis (HP:0010931)2.48561419
50Acute myeloid leukemia (HP:0004808)2.39685269
51Aplasia/Hypoplasia of the earlobes (HP:0009906)2.35272914
52Abnormality of glycolysis (HP:0004366)2.32692023
53Orthostatic hypotension (HP:0001278)2.30377694
54Onycholysis (HP:0001806)2.29858323
55Abnormality of the tricuspid valve (HP:0001702)2.26733839
56Aplastic anemia (HP:0001915)2.26033227
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24884300
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24884300
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.24089062
60Cerebral palsy (HP:0100021)2.23375857
61Increased serum pyruvate (HP:0003542)2.20038429
62Hypertensive crisis (HP:0100735)2.18864742
63Impaired platelet aggregation (HP:0003540)2.17398400
64Abnormal platelet function (HP:0011869)2.17398400
65Breast hypoplasia (HP:0003187)2.14748195
66Abnormality of the fingertips (HP:0001211)2.13878494
67Abnormality of the preputium (HP:0100587)2.13444360
68Delusions (HP:0000746)2.09759471
69Abnormality of chromosome stability (HP:0003220)2.08445485
70Abnormality of cochlea (HP:0000375)2.04946116
71Small intestinal stenosis (HP:0012848)2.03756491
72Duodenal stenosis (HP:0100867)2.03756491
73Meckel diverticulum (HP:0002245)2.02993491
74Abnormality of the heme biosynthetic pathway (HP:0010472)15.6742421
75Epistaxis (HP:0000421)1.97098478
76Abnormality of the ileum (HP:0001549)1.94568827
77Duplicated collecting system (HP:0000081)1.93834048
78Abnormality of dental color (HP:0011073)1.89797930
79Abnormality of sulfur amino acid metabolism (HP:0004339)1.89397066
80Increased serum lactate (HP:0002151)1.88129010
81Urticaria (HP:0001025)1.87994346
82Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87096917
83Nonimmune hydrops fetalis (HP:0001790)1.86237849
84Atelectasis (HP:0100750)1.86077458
85Peripheral hypomyelination (HP:0007182)1.85415315
86Oral leukoplakia (HP:0002745)1.84431684
87Myelodysplasia (HP:0002863)1.83921057
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.83400202
89Mitochondrial inheritance (HP:0001427)1.80552009
90Confusion (HP:0001289)1.79205940
91Gastrointestinal dysmotility (HP:0002579)1.79198599
92Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.78431575
93Hypopigmented skin patches (HP:0001053)1.75535994
94Hepatocellular necrosis (HP:0001404)1.75311317
95Acute necrotizing encephalopathy (HP:0006965)1.75071192
96Exertional dyspnea (HP:0002875)1.74934168
97Pancreatic islet-cell hyperplasia (HP:0004510)1.74381791
98Azoospermia (HP:0000027)1.74320287
99Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73181011
100Absent epiphyses (HP:0010577)1.73181011
101Patellar aplasia (HP:0006443)1.72808956
102Abnormality of oral frenula (HP:0000190)1.72509022
1033-Methylglutaconic aciduria (HP:0003535)1.70913645
104Upper limb muscle weakness (HP:0003484)1.70558868
105Abnormal spermatogenesis (HP:0008669)1.70441550
106Tinnitus (HP:0000360)1.68904627
107Abnormality of the renal collecting system (HP:0004742)1.68204940
108Abnormal mitochondria in muscle tissue (HP:0008316)1.66763101
109Increased CSF lactate (HP:0002490)1.65084881
110Esophageal neoplasm (HP:0100751)1.64243599
111Neoplasm of head and neck (HP:0012288)1.64243599
112Pustule (HP:0200039)1.63819211
113Abnormality of the pons (HP:0007361)1.63816082
114Type I transferrin isoform profile (HP:0003642)1.63673516
115Limb hypertonia (HP:0002509)1.61842864
116Reduced antithrombin III activity (HP:0001976)1.60048712
117Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.58744012
118Aplasia/Hypoplasia of the patella (HP:0006498)1.58529879
119Acute encephalopathy (HP:0006846)1.58220037
120Palpitations (HP:0001962)1.57287720
121Increased hepatocellular lipid droplets (HP:0006565)1.56786303
122Abnormally folded helix (HP:0008544)1.56466891
123Sandal gap (HP:0001852)1.56174541
124Hypoplasia of the pons (HP:0012110)1.55889083
125Hypoplastic iliac wings (HP:0002866)1.55813588
126Toxemia of pregnancy (HP:0100603)1.55593674
127Bone marrow hypocellularity (HP:0005528)1.55226718
128Abnormal hair whorl (HP:0010721)1.55134606
129Abnormality of the duodenum (HP:0002246)1.52399171
130Long clavicles (HP:0000890)1.51737524
131Renal tubular dysfunction (HP:0000124)1.51559225
132Pancytopenia (HP:0001876)1.51420916
133Cafe-au-lait spot (HP:0000957)1.48766866
134Lymphoma (HP:0002665)1.48301074
135Purpura (HP:0000979)1.46337381
136Morphological abnormality of the inner ear (HP:0011390)1.46015833
137Irregular epiphyses (HP:0010582)1.45396068
138Hepatic necrosis (HP:0002605)1.45329601
139Neoplasm of the liver (HP:0002896)1.44985460
140Cerebral hypomyelination (HP:0006808)1.44937227
141Clubbing of toes (HP:0100760)1.44725684
142Aplasia/Hypoplasia of the thymus (HP:0010515)1.44101575
143Overlapping toe (HP:0001845)1.43119088
144Metaphyseal cupping (HP:0003021)1.42299606
145Increased nuchal translucency (HP:0010880)1.42248705
146Ventricular fibrillation (HP:0001663)1.41786777
147Short 5th finger (HP:0009237)1.41517705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK16.58186045
2TLK14.09464821
3CDC73.66203728
4RIPK43.48171783
5VRK13.16728470
6NME23.13926286
7BUB12.97039977
8KSR22.82366667
9ZAK2.80305382
10STK162.65490708
11STK42.32910839
12PRPF4B2.20812244
13BRSK12.19108529
14RAF12.14464118
15WEE12.12569738
16BMPR22.03592358
17BMX1.99900279
18DYRK31.98850612
19MAP3K21.96195690
20BRSK21.87835456
21PBK1.82347617
22SRPK11.82271744
23NEK21.80787444
24KSR11.64288824
25NTRK31.62336638
26AURKB1.56897915
27STK101.53554049
28TTK1.48848505
29AURKA1.42217672
30PIM11.36745521
31PLK11.36684010
32ATR1.33570965
33PLK41.28056274
34WNK11.25465444
35PDK21.21923055
36IRAK31.18930331
37CLK11.18536818
38RPS6KA51.17949369
39EIF2AK21.16733295
40CHEK21.13676305
41MAP2K11.12716409
42MAPKAPK51.09881241
43ACVR1B1.07899159
44MAP3K81.06691237
45TSSK61.04305059
46NME11.00025644
47MKNK20.99383297
48CCNB10.98995995
49TRPM70.95995321
50MKNK10.94987608
51SCYL20.92098177
52PIM20.91416902
53IRAK40.90791934
54KDR0.90386446
55ICK0.87604116
56MAP3K110.86493481
57CDK70.86032535
58EIF2AK30.85786144
59CHEK10.85143435
60ATM0.83409827
61MAPK110.83314001
62MAP2K30.83141204
63CDK40.82604308
64MAP3K60.78852295
65ABL20.77966722
66SYK0.77347678
67LYN0.75018144
68PLK30.73656817
69TYK20.73405283
70BRD40.71439847
71IKBKE0.70982095
72MARK30.67631579
73CASK0.67330897
74STK240.66326096
75TESK20.65358301
76CDK120.64765416
77CDK80.64607163
78JAK20.63768492
79NEK10.62032673
80BTK0.61402936
81MAP3K10.60977808
82CSNK2A10.60018791
83GRK70.60009367
84TNIK0.59605014
85RET0.58661948
86IKBKB0.58235356
87YES10.57560516
88BLK0.57193920
89CDK190.56831622
90FLT30.55205019
91MAP4K10.54757719
92JAK30.53336471
93GRK60.52400704
94ALK0.52065641
95MST40.50976199
96PAK10.50753351
97MATK0.49715247
98CDK30.49652186
99CDK20.49618590
100CDK10.49122657
101TNK20.48949880
102RPS6KB20.48453064
103BRAF0.48280692
104CAMK1D0.47735580
105RPS6KA40.46734021
106EEF2K0.46303252
107TXK0.45731945
108DYRK20.44905867
109MAP3K100.44848239
110CSNK2A20.44203999
111SGK10.44085936
112MAP3K40.43911317
113TGFBR20.42676730
114GRK10.41422691
115MAPKAPK20.41264379
116TAOK30.40902961
117MTOR0.39896795
118MAPKAPK30.38174606
119AKT10.37132744
120MAPK30.36470839
121CDK11A0.36317254
122TAOK20.35598244
123TBK10.34995855
124GRK50.34205550
125CDK150.32048345
126WNK40.31406380
127TEC0.30866850
128PRKAA20.30013395
129CDK140.29557454
130STK30.29430859
131MAP2K70.29307902
132ERBB20.29078045
133CDK180.29033110
134PRKACG0.28065489
135MAPK140.28057602
136PRKDC0.27358671
137CDK60.26885797
138GSK3B0.25964202
139AKT20.25736457
140MAPK120.25614311
141CSNK1D0.24220983

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008607.08984406
2DNA replication_Homo sapiens_hsa030305.04706816
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.29409665
4Mismatch repair_Homo sapiens_hsa034303.28313167
5Systemic lupus erythematosus_Homo sapiens_hsa053223.23461433
6Ribosome_Homo sapiens_hsa030103.18406944
7Vitamin B6 metabolism_Homo sapiens_hsa007502.65869515
8Base excision repair_Homo sapiens_hsa034102.60328944
9Homologous recombination_Homo sapiens_hsa034402.57497196
10Nucleotide excision repair_Homo sapiens_hsa034202.56276437
11Proteasome_Homo sapiens_hsa030502.51795681
12Cell cycle_Homo sapiens_hsa041102.51391433
13Pyrimidine metabolism_Homo sapiens_hsa002402.34766288
14Fanconi anemia pathway_Homo sapiens_hsa034602.34166212
15RNA polymerase_Homo sapiens_hsa030202.32222537
16Spliceosome_Homo sapiens_hsa030402.25169578
17One carbon pool by folate_Homo sapiens_hsa006702.13268624
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09020394
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87818203
20Non-homologous end-joining_Homo sapiens_hsa034501.87382050
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78113055
22RNA transport_Homo sapiens_hsa030131.64776354
23Alcoholism_Homo sapiens_hsa050341.62083408
24Carbon metabolism_Homo sapiens_hsa012001.61774477
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57423395
26p53 signaling pathway_Homo sapiens_hsa041151.53385394
27Biosynthesis of amino acids_Homo sapiens_hsa012301.48791095
28Parkinsons disease_Homo sapiens_hsa050121.48600174
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46452449
30Hematopoietic cell lineage_Homo sapiens_hsa046401.46123197
31Acute myeloid leukemia_Homo sapiens_hsa052211.44356403
32Basal transcription factors_Homo sapiens_hsa030221.43046420
33Purine metabolism_Homo sapiens_hsa002301.35743610
34Sulfur relay system_Homo sapiens_hsa041221.34624766
35RNA degradation_Homo sapiens_hsa030181.34595005
36Oxidative phosphorylation_Homo sapiens_hsa001901.25801262
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24921375
38Huntingtons disease_Homo sapiens_hsa050161.13794184
39Steroid biosynthesis_Homo sapiens_hsa001001.12791846
40Herpes simplex infection_Homo sapiens_hsa051681.07758344
41Thyroid cancer_Homo sapiens_hsa052161.07746289
42Protein export_Homo sapiens_hsa030601.07044964
43Fructose and mannose metabolism_Homo sapiens_hsa000511.04820421
44ABC transporters_Homo sapiens_hsa020101.01378934
45Viral carcinogenesis_Homo sapiens_hsa052031.00094909
46Malaria_Homo sapiens_hsa051440.97520305
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95315682
48Nitrogen metabolism_Homo sapiens_hsa009100.94019173
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92625195
50Pancreatic cancer_Homo sapiens_hsa052120.91933560
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91175620
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90370388
53HIF-1 signaling pathway_Homo sapiens_hsa040660.88351115
54Glutathione metabolism_Homo sapiens_hsa004800.85951391
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85305204
56Selenocompound metabolism_Homo sapiens_hsa004500.81158857
57Propanoate metabolism_Homo sapiens_hsa006400.80588420
58mRNA surveillance pathway_Homo sapiens_hsa030150.79137466
59Folate biosynthesis_Homo sapiens_hsa007900.75453129
60Fatty acid metabolism_Homo sapiens_hsa012120.74946595
61Type II diabetes mellitus_Homo sapiens_hsa049300.74375055
62mTOR signaling pathway_Homo sapiens_hsa041500.72238884
63Alzheimers disease_Homo sapiens_hsa050100.71149153
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71134678
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70739459
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.69967281
67Olfactory transduction_Homo sapiens_hsa047400.68294116
68Renal cell carcinoma_Homo sapiens_hsa052110.67844623
69Epstein-Barr virus infection_Homo sapiens_hsa051690.66966862
70Measles_Homo sapiens_hsa051620.66650095
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66572289
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61507830
73Apoptosis_Homo sapiens_hsa042100.60696596
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54246569
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.53492613
76Pentose phosphate pathway_Homo sapiens_hsa000300.53113867
77Metabolic pathways_Homo sapiens_hsa011000.51207989
78Oocyte meiosis_Homo sapiens_hsa041140.49799093
79Butanoate metabolism_Homo sapiens_hsa006500.48420184
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48338251
81Arginine biosynthesis_Homo sapiens_hsa002200.47669984
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46911338
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45577813
84MicroRNAs in cancer_Homo sapiens_hsa052060.43698617
85Arachidonic acid metabolism_Homo sapiens_hsa005900.43567742
86VEGF signaling pathway_Homo sapiens_hsa043700.43214753
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.42654058
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42447535
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41622244
90ErbB signaling pathway_Homo sapiens_hsa040120.41192580
91Hepatitis B_Homo sapiens_hsa051610.41087516
92Glioma_Homo sapiens_hsa052140.41041315
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40355374
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.38795542
95Fatty acid elongation_Homo sapiens_hsa000620.38621764
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38070052
97Insulin signaling pathway_Homo sapiens_hsa049100.36092964
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34625655
99Prolactin signaling pathway_Homo sapiens_hsa049170.34257474
100Antigen processing and presentation_Homo sapiens_hsa046120.33028830
101Small cell lung cancer_Homo sapiens_hsa052220.32935455
102Primary immunodeficiency_Homo sapiens_hsa053400.32424300
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32319903
104Collecting duct acid secretion_Homo sapiens_hsa049660.28989798
105HTLV-I infection_Homo sapiens_hsa051660.28982403
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27794253
107Caffeine metabolism_Homo sapiens_hsa002320.26621990
108AMPK signaling pathway_Homo sapiens_hsa041520.25624904
109B cell receptor signaling pathway_Homo sapiens_hsa046620.25459306
110Bladder cancer_Homo sapiens_hsa052190.24993608
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.24564597
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.24162817
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.23250002
114N-Glycan biosynthesis_Homo sapiens_hsa005100.22695440
115Legionellosis_Homo sapiens_hsa051340.21765800
116Influenza A_Homo sapiens_hsa051640.20233628
117Linoleic acid metabolism_Homo sapiens_hsa005910.17508632
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17369202
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.15285581
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14500984
121Asthma_Homo sapiens_hsa053100.12848996
122Pyruvate metabolism_Homo sapiens_hsa006200.12331339
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10724804
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09775074
125Regulation of autophagy_Homo sapiens_hsa041400.09064935
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08863172
127Cardiac muscle contraction_Homo sapiens_hsa042600.08362176
128Leishmaniasis_Homo sapiens_hsa051400.07704520
129Chronic myeloid leukemia_Homo sapiens_hsa052200.06780843
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.05560638
131Ether lipid metabolism_Homo sapiens_hsa005650.05338108
132Non-small cell lung cancer_Homo sapiens_hsa052230.05247938
133Hepatitis C_Homo sapiens_hsa051600.04678174
134Other glycan degradation_Homo sapiens_hsa005110.03386178
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.00465650
136Arginine and proline metabolism_Homo sapiens_hsa003300.00385703
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.00229348
138Graft-versus-host disease_Homo sapiens_hsa053320.00073726
139Prostate cancer_Homo sapiens_hsa05215-0.0102367
140Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0083371
141beta-Alanine metabolism_Homo sapiens_hsa00410-0.0077204

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