RHBDD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte differentiation (GO:0030854)4.84343842
2regulation of B cell receptor signaling pathway (GO:0050855)4.39607452
3Golgi transport vesicle coating (GO:0048200)4.34482459
4COPI coating of Golgi vesicle (GO:0048205)4.34482459
5regulation of platelet aggregation (GO:0090330)4.01854258
6tyrosine phosphorylation of STAT protein (GO:0007260)3.88144400
7neutrophil activation involved in immune response (GO:0002283)3.86406889
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85152929
9regulation of female gonad development (GO:2000194)3.84028546
10thrombin receptor signaling pathway (GO:0070493)3.78942758
11B cell receptor signaling pathway (GO:0050853)3.72637294
12alpha-linolenic acid metabolic process (GO:0036109)3.72152200
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.67891295
14L-phenylalanine catabolic process (GO:0006559)3.67891295
15negative regulation of fibrinolysis (GO:0051918)3.65695467
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.64402142
17negative regulation of cell killing (GO:0031342)3.64402142
18megakaryocyte development (GO:0035855)3.62793789
19L-phenylalanine metabolic process (GO:0006558)3.59262701
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.59262701
21peptidyl-glutamic acid carboxylation (GO:0017187)3.55952035
22protein carboxylation (GO:0018214)3.55952035
23cysteine metabolic process (GO:0006534)3.50541866
24low-density lipoprotein particle clearance (GO:0034383)3.50509940
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49235841
26regulation of regulatory T cell differentiation (GO:0045589)3.43025671
27sulfur amino acid catabolic process (GO:0000098)3.41227326
28valine metabolic process (GO:0006573)3.39678090
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.37871204
30protein neddylation (GO:0045116)3.33877740
31lysine metabolic process (GO:0006553)3.29729784
32lysine catabolic process (GO:0006554)3.29729784
33COPII vesicle coating (GO:0048208)3.28943587
344-hydroxyproline metabolic process (GO:0019471)3.27864167
35positive regulation of macrophage differentiation (GO:0045651)3.27421511
36maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.25509293
37positive regulation of endothelial cell differentiation (GO:0045603)3.23883007
38regulation of interferon-beta biosynthetic process (GO:0045357)3.23484690
39antigen processing and presentation via MHC class Ib (GO:0002475)3.22414735
40hypotonic response (GO:0006971)3.18495502
41hepatocyte apoptotic process (GO:0097284)3.17803883
42regulation of platelet activation (GO:0010543)3.16987225
43plasma lipoprotein particle clearance (GO:0034381)3.16391197
44positive regulation of gamma-delta T cell activation (GO:0046645)3.16304612
45complement activation, alternative pathway (GO:0006957)3.16001302
46aromatic amino acid family catabolic process (GO:0009074)3.15262849
47regulation of cholesterol homeostasis (GO:2000188)3.12740732
48negative regulation of T-helper cell differentiation (GO:0045623)3.10796320
49negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.10796320
50positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.10573134
51microtubule severing (GO:0051013)3.10007030
52regulation of fibrinolysis (GO:0051917)3.07048260
53B cell proliferation (GO:0042100)3.06206784
54regulation of protein activation cascade (GO:2000257)3.05866817
55positive regulation of mast cell activation (GO:0033005)3.04140561
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.03341564
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.03341564
58activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.03165919
59high-density lipoprotein particle remodeling (GO:0034375)3.02062197
60oxygen transport (GO:0015671)3.01185349
61urea metabolic process (GO:0019627)2.99061670
62urea cycle (GO:0000050)2.99061670
63amino-acid betaine metabolic process (GO:0006577)2.96905589
64positive regulation of alpha-beta T cell proliferation (GO:0046641)2.96620903
65protoporphyrinogen IX metabolic process (GO:0046501)2.96540465
66regulation of complement activation (GO:0030449)2.93563427
67leukocyte migration involved in inflammatory response (GO:0002523)2.92305343
68positive regulation of nuclease activity (GO:0032075)2.91510547
69regulation of T-helper 1 cell differentiation (GO:0045625)2.90676067
70regulation of triglyceride catabolic process (GO:0010896)2.89186763
71platelet aggregation (GO:0070527)2.88980172
72homocysteine metabolic process (GO:0050667)2.88852930
73purinergic nucleotide receptor signaling pathway (GO:0035590)2.88778843
74histone mRNA catabolic process (GO:0071044)2.88095164
75negative T cell selection (GO:0043383)2.87925187
76peptide catabolic process (GO:0043171)2.87460099
77fibrinolysis (GO:0042730)2.87200128
78kynurenine metabolic process (GO:0070189)2.87166580
79endoplasmic reticulum unfolded protein response (GO:0030968)2.85929497
80negative regulation of stress fiber assembly (GO:0051497)2.85428345
81intestinal cholesterol absorption (GO:0030299)2.85329255
82regulation of homotypic cell-cell adhesion (GO:0034110)2.84383798
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.84173427
84reverse cholesterol transport (GO:0043691)2.83335484
85protein targeting to Golgi (GO:0000042)2.83002271
86establishment of protein localization to Golgi (GO:0072600)2.82999181
87apoptotic cell clearance (GO:0043277)2.82132911
88retrograde transport, vesicle recycling within Golgi (GO:0000301)2.81683951
89tyrosine metabolic process (GO:0006570)2.81616589
90protein retention in ER lumen (GO:0006621)2.80455490
91negative thymic T cell selection (GO:0045060)2.80396596
92positive regulation of isotype switching (GO:0045830)2.79656673
93regulation of granulocyte differentiation (GO:0030852)2.78954909
94G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.78675251
95phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.77604110
96tryptophan metabolic process (GO:0006568)2.77165448
97cell adhesion mediated by integrin (GO:0033627)2.75857955
98* cellular response to unfolded protein (GO:0034620)2.75596884
99positive thymic T cell selection (GO:0045059)2.75029834
100regulation of histone H3-K9 methylation (GO:0051570)2.74160283
101macroautophagy (GO:0016236)2.73380613
102negative regulation of sterol transport (GO:0032372)2.73047517
103negative regulation of cholesterol transport (GO:0032375)2.73047517
104multicellular organism reproduction (GO:0032504)2.72825583
105regulation of membrane protein ectodomain proteolysis (GO:0051043)2.72817833
106positive T cell selection (GO:0043368)2.72626117
107negative regulation of T cell mediated immunity (GO:0002710)2.70045862
108ER-nucleus signaling pathway (GO:0006984)2.69684188
109regulation of cholesterol storage (GO:0010885)2.68795235
110negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.68777585
111indole-containing compound catabolic process (GO:0042436)2.68602291
112indolalkylamine catabolic process (GO:0046218)2.68602291
113tryptophan catabolic process (GO:0006569)2.68602291
114cellular modified amino acid catabolic process (GO:0042219)2.68500087
115glyoxylate metabolic process (GO:0046487)2.68498163
116Arp2/3 complex-mediated actin nucleation (GO:0034314)2.67723305
117bile acid biosynthetic process (GO:0006699)2.67214373
118regulation of nuclease activity (GO:0032069)2.66691345
119angiogenesis involved in wound healing (GO:0060055)2.66454317
120polyamine biosynthetic process (GO:0006596)2.65305032
121phospholipid homeostasis (GO:0055091)2.64921455
122regulation of alpha-beta T cell proliferation (GO:0046640)2.63309639
123negative regulation of homotypic cell-cell adhesion (GO:0034111)2.62613266
124gas transport (GO:0015669)2.62507715
125tricarboxylic acid metabolic process (GO:0072350)2.62435218
126positive regulation of blood coagulation (GO:0030194)2.62040413
127positive regulation of hemostasis (GO:1900048)2.62040413
128skin morphogenesis (GO:0043589)2.61774098
129histone H3-K36 demethylation (GO:0070544)2.61563184
130nitrogen cycle metabolic process (GO:0071941)2.61257015
131positive regulation of coagulation (GO:0050820)2.60874509
132negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.59263725
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.58564071
134carnitine metabolic process (GO:0009437)2.57768056
135* cellular response to topologically incorrect protein (GO:0035967)2.57679706
136macrophage activation involved in immune response (GO:0002281)2.56809116
137plasma lipoprotein particle assembly (GO:0034377)2.56411495
138regulation of integrin-mediated signaling pathway (GO:2001044)2.56398750
139positive regulation of B cell mediated immunity (GO:0002714)2.56157263
140positive regulation of immunoglobulin mediated immune response (GO:0002891)2.56157263
141regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55568652
142antigen processing and presentation of endogenous antigen (GO:0019883)2.55530773
143immunoglobulin mediated immune response (GO:0016064)2.55423567
144acute-phase response (GO:0006953)2.55361448
145regulation of fatty acid beta-oxidation (GO:0031998)2.55183329
1462-oxoglutarate metabolic process (GO:0006103)2.54651174
147lipoprotein metabolic process (GO:0042157)2.54566765
148phospholipid efflux (GO:0033700)2.54178083
149protein-lipid complex assembly (GO:0065005)2.53876205
150acylglycerol homeostasis (GO:0055090)2.53630183
151triglyceride homeostasis (GO:0070328)2.53630183
152negative regulation of fatty acid biosynthetic process (GO:0045717)2.52788268
153retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.52443865
154regulation of integrin activation (GO:0033623)2.52261334
155hormone catabolic process (GO:0042447)2.51999783
156protein-lipid complex remodeling (GO:0034368)2.51887219
157macromolecular complex remodeling (GO:0034367)2.51887219
158plasma lipoprotein particle remodeling (GO:0034369)2.51887219
159positive regulation of DNA recombination (GO:0045911)2.51716140
160positive regulation of B cell differentiation (GO:0045579)2.51194837
161fatty acid oxidation (GO:0019395)2.50206178
162epithelial cilium movement (GO:0003351)2.49996321
163modulation by symbiont of host immune response (GO:0052553)2.49431461
164positive regulation by symbiont of host defense response (GO:0052509)2.49431461
165modulation by symbiont of host defense response (GO:0052031)2.49431461
166modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.49431461
167modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.49431461
168positive regulation by organism of defense response of other organism involved in symbiotic interact2.49431461
169myeloid cell development (GO:0061515)2.49366835
170dicarboxylic acid biosynthetic process (GO:0043650)2.49036437
171myeloid cell activation involved in immune response (GO:0002275)2.48655626
172positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.47018742
173bile acid metabolic process (GO:0008206)2.46284817
174lipid oxidation (GO:0034440)2.45396252
175epoxygenase P450 pathway (GO:0019373)2.45375514
176actin nucleation (GO:0045010)2.44470656
177negative regulation of T cell apoptotic process (GO:0070233)2.43474349
178fatty acid beta-oxidation (GO:0006635)2.42517253
179regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.42081089
180aromatic amino acid family metabolic process (GO:0009072)2.41814511
181negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.41505022
182regulation of memory T cell differentiation (GO:0043380)2.40542761
183termination of signal transduction (GO:0023021)2.40091251
184negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.39370281
185interkinetic nuclear migration (GO:0022027)2.38842066
186cilium movement (GO:0003341)2.37654925
187B cell mediated immunity (GO:0019724)2.37053832
188positive regulation of type 2 immune response (GO:0002830)2.35809482
189termination of G-protein coupled receptor signaling pathway (GO:0038032)2.35458486
190autophagic vacuole fusion (GO:0000046)2.35447383
191definitive hemopoiesis (GO:0060216)2.35249982
192regulation of interleukin-8 secretion (GO:2000482)2.34236377
193regulation of B cell differentiation (GO:0045577)2.33926127
194positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.32716896
195T cell selection (GO:0045058)2.30955076
196detection of other organism (GO:0098543)2.30521589
197neutrophil activation (GO:0042119)2.30272299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.75832397
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.29805351
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.06052340
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.65948173
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.29025215
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.05067712
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.05016558
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.77902525
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76971358
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.53250437
11GATA1_22025678_ChIP-Seq_K562_Human2.49180709
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.47729453
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.43797298
14SCL_19346495_ChIP-Seq_HPC-7_Human2.31336866
15* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.25255536
16CLOCK_20551151_ChIP-Seq_293T_Human2.25219695
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22666784
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19498929
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.18930475
20* GATA2_19941826_ChIP-Seq_K562_Human2.15828236
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03206394
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01329787
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99145943
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.95004403
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94743263
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.94713547
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.93823053
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93476336
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89368003
30* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.87607658
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82775229
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.81503305
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79991593
34CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.79653432
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77148018
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73990755
37SPI1_23127762_ChIP-Seq_K562_Human1.73795842
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72452582
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71442127
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69857099
41* GATA1_19941827_ChIP-Seq_MEL_Mouse1.69524955
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63012607
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59767545
44* FLI1_27457419_Chip-Seq_LIVER_Mouse1.59407880
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.57373333
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55811840
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54390883
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.54233526
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53900373
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52182588
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48705487
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43484497
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.43202211
54SALL4_22934838_ChIP-ChIP_CD34+_Human1.39546998
55* GATA3_26560356_Chip-Seq_TH2_Human1.39517187
56TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.39199610
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37575511
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37253615
59GATA4_25053715_ChIP-Seq_YYC3_Human1.35198588
60SPI1_23547873_ChIP-Seq_NB4_Human1.33553449
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32870042
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31733641
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30996410
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30391027
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.28263350
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27472606
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.27015349
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26456038
69IRF1_19129219_ChIP-ChIP_H3396_Human1.26352799
70SMRT_27268052_Chip-Seq_Bcells_Human1.26318758
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25729006
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25184279
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24574447
74KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24315254
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23768968
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22963974
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22676527
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22121584
79FOXA2_19822575_ChIP-Seq_HepG2_Human1.21355606
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21276592
81GATA6_25053715_ChIP-Seq_YYC3_Human1.21194549
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19608405
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19587380
84* MYB_26560356_Chip-Seq_TH2_Human1.18311203
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16431075
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16319753
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16318641
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.14813680
89* EZH2_27294783_Chip-Seq_NPCs_Mouse1.14008041
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13497410
91ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13336316
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12301116
93ATF3_27146783_Chip-Seq_COLON_Human1.11496022
94PU_27001747_Chip-Seq_BMDM_Mouse1.11457557
95PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11236159
96* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10920666
97* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10920666
98GATA3_26560356_Chip-Seq_TH1_Human1.09252041
99GATA1_19941827_ChIP-Seq_MEL86_Mouse1.08591330
100MYB_26560356_Chip-Seq_TH1_Human1.08441263
101RUNX_20019798_ChIP-Seq_JUKART_Human1.06951300
102MAF_26560356_Chip-Seq_TH1_Human1.05477814
103* GATA3_27048872_Chip-Seq_THYMUS_Human1.04076657
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03493742
105FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03192815
106NCOR1_26117541_ChIP-Seq_K562_Human1.02625237
107* NFE2_27457419_Chip-Seq_LIVER_Mouse1.02162920
108* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02130326
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01597772
110MYC_22102868_ChIP-Seq_BL_Human1.01519910
111* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01019127
112TFEB_21752829_ChIP-Seq_HELA_Human0.99955541
113GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99196240
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98945596
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98900543
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98548558
117CDX2_22108803_ChIP-Seq_LS180_Human0.98159641
118RUNX1_22412390_ChIP-Seq_EML_Mouse0.97943980
119* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97769060
120GATA1_19941826_ChIP-Seq_K562_Human0.96951145
121TBX20_22080862_ChIP-Seq_HEART_Mouse0.96778818
122TBX20_22328084_ChIP-Seq_HEART_Mouse0.96778818
123CJUN_26792858_Chip-Seq_BT549_Human0.96117115
124E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96051139
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95753163
126ELK3_25401928_ChIP-Seq_HUVEC_Human0.95516159
127* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94887322
128RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94641698
129GATA3_21878914_ChIP-Seq_MCF-7_Human0.94312402
130ZNF263_19887448_ChIP-Seq_K562_Human0.94264305
131TCF7_22412390_ChIP-Seq_EML_Mouse0.93348237
132SOX2_20726797_ChIP-Seq_SW620_Human0.93153159
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92880561
134* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92467202
135* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92325068
136UTX_26944678_Chip-Seq_JUKART_Human0.92220350
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92216380
138TP63_23658742_ChIP-Seq_EP156T_Human0.92178622
139BRD4_25478319_ChIP-Seq_HGPS_Human0.91980375
140STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91663759
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91198231
142TCF4_23295773_ChIP-Seq_U87_Human0.90714938
143EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90445739
144STAT3_23295773_ChIP-Seq_U87_Human0.90161070
145JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88924227
146JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88822975
147EZH2_22144423_ChIP-Seq_EOC_Human0.88820646
148STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88319923
149* CRX_20693478_ChIP-Seq_RETINA_Mouse0.87964962
150KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86788469
151UBF1/2_26484160_Chip-Seq_HMECs_Human0.85579706
152CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85458784
153VDR_24763502_ChIP-Seq_THP-1_Human0.85001259
154AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84989681
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84816377
156ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84739235
157HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84553642
158ER_23166858_ChIP-Seq_MCF-7_Human0.84357187
159PRDM14_20953172_ChIP-Seq_ESCs_Human0.83167444
160NANOG_20526341_ChIP-Seq_ESCs_Human0.82164714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.74863293
2MP0005365_abnormal_bile_salt3.32620851
3MP0005360_urolithiasis3.22395247
4MP0000569_abnormal_digit_pigmentation3.21845096
5MP0003300_gastrointestinal_ulcer2.77439014
6MP0005085_abnormal_gallbladder_physiolo2.71204424
7MP0003705_abnormal_hypodermis_morpholog2.61992887
8MP0003252_abnormal_bile_duct2.57369970
9MP0009840_abnormal_foam_cell2.39134138
10MP0008438_abnormal_cutaneous_collagen2.38710445
11MP0008004_abnormal_stomach_pH2.25433289
12MP0005058_abnormal_lysosome_morphology2.24700389
13MP0002877_abnormal_melanocyte_morpholog2.09175628
14MP0003806_abnormal_nucleotide_metabolis2.07983357
15MP0005083_abnormal_biliary_tract2.06442204
16MP0008875_abnormal_xenobiotic_pharmacok2.06067820
17MP0003763_abnormal_thymus_physiology1.96443326
18MP0005410_abnormal_fertilization1.89046905
19MP0002398_abnormal_bone_marrow1.88989810
20MP0001666_abnormal_nutrient_absorption1.87379319
21MP0003195_calcinosis1.85459933
22MP0010329_abnormal_lipoprotein_level1.85208573
23MP0005671_abnormal_response_to1.83017767
24MP0000689_abnormal_spleen_morphology1.79634835
25MP0002420_abnormal_adaptive_immunity1.72362902
26MP0003566_abnormal_cell_adhesion1.70932359
27MP0000609_abnormal_liver_physiology1.70034456
28MP0001819_abnormal_immune_cell1.68378595
29MP0003436_decreased_susceptibility_to1.64707266
30MP0005310_abnormal_salivary_gland1.58963439
31MP0008877_abnormal_DNA_methylation1.56169631
32MP0002138_abnormal_hepatobiliary_system1.54745054
33MP0010352_gastrointestinal_tract_polyps1.54455056
34MP0003191_abnormal_cellular_cholesterol1.49290131
35MP0004084_abnormal_cardiac_muscle1.47985920
36MP0000716_abnormal_immune_system1.47220001
37MP0004947_skin_inflammation1.46342122
38MP0000015_abnormal_ear_pigmentation1.45103208
39MP0005023_abnormal_wound_healing1.41702196
40MP0006054_spinal_hemorrhage1.41467218
41MP0010234_abnormal_vibrissa_follicle1.39074737
42MP0002009_preneoplasia1.38659529
43MP0002429_abnormal_blood_cell1.36809180
44MP0008057_abnormal_DNA_replication1.35684303
45MP0002722_abnormal_immune_system1.35661644
46MP0005275_abnormal_skin_tensile1.34902584
47MP0003718_maternal_effect1.33708337
48MP0009384_cardiac_valve_regurgitation1.33231924
49MP0003172_abnormal_lysosome_physiology1.30737492
50MP0002148_abnormal_hypersensitivity_rea1.30277178
51MP0005220_abnormal_exocrine_pancreas1.29650861
52MP0005332_abnormal_amino_acid1.29593350
53MP0005319_abnormal_enzyme/_coenzyme1.28507623
54MP0002118_abnormal_lipid_homeostasis1.28447771
55MP0002405_respiratory_system_inflammati1.26850047
56MP0009643_abnormal_urine_homeostasis1.26743997
57MP0003828_pulmonary_edema1.24899900
58MP0003303_peritoneal_inflammation1.21170003
59MP0006082_CNS_inflammation1.19723758
60MP0002060_abnormal_skin_morphology1.18567064
61MP0005076_abnormal_cell_differentiation1.17815009
62MP0003279_aneurysm1.16459567
63MP0008775_abnormal_heart_ventricle1.15828459
64MP0005464_abnormal_platelet_physiology1.14702498
65MP0001533_abnormal_skeleton_physiology1.14433473
66MP0005164_abnormal_response_to1.14365096
67MP0000703_abnormal_thymus_morphology1.10980920
68MP0003656_abnormal_erythrocyte_physiolo1.09345014
69MP0000598_abnormal_liver_morphology1.08882907
70MP0008469_abnormal_protein_level1.08330515
71MP0002419_abnormal_innate_immunity1.06484187
72MP0002166_altered_tumor_susceptibility1.06180659
73MP0002928_abnormal_bile_duct1.06140298
74MP0000685_abnormal_immune_system1.05966476
75MP0003868_abnormal_feces_composition1.02533192
76MP0009333_abnormal_splenocyte_physiolog1.01905681
77MP0005670_abnormal_white_adipose1.00928958
78MP0009764_decreased_sensitivity_to1.00736446
79MP0005257_abnormal_intraocular_pressure1.00460914
80MP0004883_abnormal_blood_vessel0.99553653
81MP0003950_abnormal_plasma_membrane0.99225565
82MP0000858_altered_metastatic_potential0.98233125
83MP0003453_abnormal_keratinocyte_physiol0.97853933
84MP0000343_altered_response_to0.97137327
85MP0004036_abnormal_muscle_relaxation0.97116807
86MP0003724_increased_susceptibility_to0.97036427
87MP0000249_abnormal_blood_vessel0.96477220
88MP0010307_abnormal_tumor_latency0.94979559
89MP0004134_abnormal_chest_morphology0.94834410
90MP0001845_abnormal_inflammatory_respons0.94714646
91MP0003091_abnormal_cell_migration0.94137938
92MP0000230_abnormal_systemic_arterial0.93831189
93MP0004484_altered_response_of0.92721583
94MP0004808_abnormal_hematopoietic_stem0.92284056
95MP0002132_abnormal_respiratory_system0.91662236
96MP0001790_abnormal_immune_system0.90757777
97MP0005387_immune_system_phenotype0.90757777
98MP0005397_hematopoietic_system_phenotyp0.90566005
99MP0001545_abnormal_hematopoietic_system0.90566005
100MP0009785_altered_susceptibility_to0.90554408
101MP0001835_abnormal_antigen_presentation0.90495174
102MP0002933_joint_inflammation0.90407375
103MP0004130_abnormal_muscle_cell0.90250145
104MP0000604_amyloidosis0.89484347
105MP0001348_abnormal_lacrimal_gland0.89296715
106MP0009763_increased_sensitivity_to0.89113861
107MP0002896_abnormal_bone_mineralization0.88812547
108MP0004264_abnormal_extraembryonic_tissu0.88425682
109MP0001873_stomach_inflammation0.88319350
110MP0004381_abnormal_hair_follicle0.88187959
111MP0002693_abnormal_pancreas_physiology0.86558923
112MP0003186_abnormal_redox_activity0.84675523
113MP0005075_abnormal_melanosome_morpholog0.84129900
114MP0001661_extended_life_span0.84018701
115MP0005000_abnormal_immune_tolerance0.83873287
116MP0001944_abnormal_pancreas_morphology0.83691128
117MP0008260_abnormal_autophagy0.83598365
118MP0001542_abnormal_bone_strength0.83420341
119MP0001800_abnormal_humoral_immune0.82226400
120MP0002254_reproductive_system_inflammat0.81983023
121MP0003787_abnormal_imprinting0.81879326
122MP0005025_abnormal_response_to0.81879317
123MP0005395_other_phenotype0.79861891
124MP0004185_abnormal_adipocyte_glucose0.79546029
125MP0002998_abnormal_bone_remodeling0.79325930
126MP0008961_abnormal_basal_metabolism0.78892975
127MP0001879_abnormal_lymphatic_vessel0.78868484
128MP0005408_hypopigmentation0.78402058
129MP0002452_abnormal_antigen_presenting0.78330633
130MP0003866_abnormal_defecation0.77927236
131MP0003045_fibrosis0.77471492
132MP0001243_abnormal_dermal_layer0.76942235
133MP0002168_other_aberrant_phenotype0.76464224
134MP0010155_abnormal_intestine_physiology0.75531791
135MP0004019_abnormal_vitamin_homeostasis0.75132732
136MP0009115_abnormal_fat_cell0.75077020
137MP0005666_abnormal_adipose_tissue0.74925222
138MP0001929_abnormal_gametogenesis0.74684256
139MP0005584_abnormal_enzyme/coenzyme_acti0.74491970
140MP0005503_abnormal_tendon_morphology0.73899670
141MP0001958_emphysema0.73757579
142MP0010368_abnormal_lymphatic_system0.73364532
143MP0002078_abnormal_glucose_homeostasis0.73076103
144MP0009780_abnormal_chondrocyte_physiolo0.72950761
145MP0002006_tumorigenesis0.72784471
146MP0002136_abnormal_kidney_physiology0.71554315
147MP0002723_abnormal_immune_serum0.71282145
148MP0005174_abnormal_tail_pigmentation0.70980352
149MP0001851_eye_inflammation0.70657503
150MP0003448_altered_tumor_morphology0.70568585
151MP0004147_increased_porphyrin_level0.69942417
152MP0002971_abnormal_brown_adipose0.69531887
153MP0003795_abnormal_bone_structure0.69405458
154MP0003183_abnormal_peptide_metabolism0.66440878
155MP0000465_gastrointestinal_hemorrhage0.65730981
156MP0005390_skeleton_phenotype0.65110627

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)6.02069050
2Petechiae (HP:0000967)4.62420359
3Epistaxis (HP:0000421)4.55098147
4Poikilocytosis (HP:0004447)4.37585025
5Deep venous thrombosis (HP:0002625)4.35026208
6Purpura (HP:0000979)4.20379693
7Spontaneous hematomas (HP:0007420)3.94526092
8Intrahepatic cholestasis (HP:0001406)3.87350586
9Xanthomatosis (HP:0000991)3.78505275
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.60138768
11Abnormality of the common coagulation pathway (HP:0010990)3.50030249
12Hypoglycemic coma (HP:0001325)3.49329489
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.48480846
14Recurrent bronchitis (HP:0002837)3.43603047
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.40452880
16Abnormality of the intrinsic pathway (HP:0010989)3.36857001
17Myocardial infarction (HP:0001658)3.35976425
18Agammaglobulinemia (HP:0004432)3.28783827
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.27102501
20Hyperlipoproteinemia (HP:0010980)3.26767419
21Autoimmune hemolytic anemia (HP:0001890)3.25045756
22Abnormal platelet function (HP:0011869)3.19035116
23Impaired platelet aggregation (HP:0003540)3.19035116
24T lymphocytopenia (HP:0005403)3.15988576
25Acanthocytosis (HP:0001927)3.14600854
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.09946081
27Complement deficiency (HP:0004431)3.05744242
28Elevated erythrocyte sedimentation rate (HP:0003565)3.03384096
29Inflammation of the large intestine (HP:0002037)3.02399751
30Prolonged partial thromboplastin time (HP:0003645)2.86932269
31Chronic hepatic failure (HP:0100626)2.85340202
32Bronchitis (HP:0012387)2.81656690
33Dysostosis multiplex (HP:0000943)2.79288902
34Abnormality of T cell number (HP:0011839)2.76805459
35Mucopolysacchariduria (HP:0008155)2.75436090
36Urinary glycosaminoglycan excretion (HP:0003541)2.75436090
37Tubulointerstitial nephritis (HP:0001970)2.74444383
38Gastrointestinal stroma tumor (HP:0100723)2.74400419
39Hypoalphalipoproteinemia (HP:0003233)2.73316147
40Vacuolated lymphocytes (HP:0001922)2.73270872
41Recurrent sinusitis (HP:0011108)2.71101201
42Thrombocytosis (HP:0001894)2.67679553
43Colitis (HP:0002583)2.67345620
44Hypobetalipoproteinemia (HP:0003563)2.66832287
45Premature rupture of membranes (HP:0001788)2.63695032
46Ketosis (HP:0001946)2.63314459
47Fat malabsorption (HP:0002630)2.62674766
48Hypoglycemic seizures (HP:0002173)2.62672926
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60265570
50Abnormality of polysaccharide metabolism (HP:0011012)2.60265570
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60265570
52Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.60221472
53Gastrointestinal inflammation (HP:0004386)2.59438972
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.58530128
55Osteolytic defects of the hand bones (HP:0009699)2.58530128
56Hypolipoproteinemia (HP:0010981)2.58018026
57Increased cerebral lipofuscin (HP:0011813)2.57234693
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56445525
59Rhinitis (HP:0012384)2.55827700
60Renal cortical cysts (HP:0000803)2.55524400
61Osteomyelitis (HP:0002754)2.54630346
62Abnormality of complement system (HP:0005339)2.53497755
63Joint hemorrhage (HP:0005261)2.52156141
64Recurrent viral infections (HP:0004429)2.49209452
65Abnormal ciliary motility (HP:0012262)2.48671732
66Esophageal varix (HP:0002040)2.46789301
67Bruising susceptibility (HP:0000978)2.46290499
68Abnormal respiratory motile cilium physiology (HP:0012261)2.45055035
69Vasculitis (HP:0002633)2.44301681
70Systemic lupus erythematosus (HP:0002725)2.42625250
71Epidermoid cyst (HP:0200040)2.42220720
72Hyperinsulinemic hypoglycemia (HP:0000825)2.41511044
73Abnormality of the renal cortex (HP:0011035)2.36794599
74Lymphopenia (HP:0001888)2.36125452
75Abnormality of proline metabolism (HP:0010907)2.32410002
76Hydroxyprolinuria (HP:0003080)2.32410002
77Aortic aneurysm (HP:0004942)2.31909315
78Absent/shortened dynein arms (HP:0200106)2.31626010
79Dynein arm defect of respiratory motile cilia (HP:0012255)2.31626010
80Peritonitis (HP:0002586)2.31441683
81Protrusio acetabuli (HP:0003179)2.31264888
82Upper limb muscle weakness (HP:0003484)2.30824806
83Skin nodule (HP:0200036)2.30681691
84Tetraparesis (HP:0002273)2.29566822
85Recurrent bacterial skin infections (HP:0005406)2.29540616
86Recurrent gram-negative bacterial infections (HP:0005420)2.28737390
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.28319608
88Abnormality of macrophages (HP:0004311)2.26910976
89Ketoacidosis (HP:0001993)2.26173567
90Abnormality of sulfur amino acid metabolism (HP:0004339)2.24974259
91Cervical subluxation (HP:0003308)2.24963107
92Hypercholesterolemia (HP:0003124)2.23098705
93Nasal polyposis (HP:0100582)2.19597546
94Paralysis (HP:0003470)2.19266880
95Bronchiectasis (HP:0002110)2.17417271
96Abnormality of T cells (HP:0002843)2.16625907
97Cerebral aneurysm (HP:0004944)2.16472374
98Microcytic anemia (HP:0001935)2.15876434
99Chronic diarrhea (HP:0002028)2.14853211
100IgM deficiency (HP:0002850)2.13573123
101Hyperammonemia (HP:0001987)2.12167965
102Cellulitis (HP:0100658)2.12017671
103IgA deficiency (HP:0002720)2.10709172
104Right ventricular cardiomyopathy (HP:0011663)2.10568150
105Asymmetric septal hypertrophy (HP:0001670)2.08634791
106Chest pain (HP:0100749)2.06867754
107Panhypogammaglobulinemia (HP:0003139)2.06707284
108Chronic mucocutaneous candidiasis (HP:0002728)2.05633259
109Recurrent cutaneous fungal infections (HP:0011370)2.05633259
110Abnormality of cells of the lymphoid lineage (HP:0012140)2.05164123
111Abnormality of the nasal mucosa (HP:0000433)2.04734568
112Abnormal pancreas size (HP:0012094)2.04203563
113Hepatocellular carcinoma (HP:0001402)2.03848126
114Meningitis (HP:0001287)2.03336623
115Hematochezia (HP:0002573)2.02714623
116Anhidrosis (HP:0000970)2.02421405
117Steatorrhea (HP:0002570)2.02227896
118Cardiovascular calcification (HP:0011915)2.01549056
119Interstitial pulmonary disease (HP:0006530)2.01383696
120Recurrent abscess formation (HP:0002722)2.00608237
121Aneurysm (HP:0002617)1.98942965
122Osteomalacia (HP:0002749)1.98025839
123Menorrhagia (HP:0000132)1.97611255
124Portal hypertension (HP:0001409)1.96873141
125Abnormal delayed hypersensitivity skin test (HP:0002963)1.96646167
126Albinism (HP:0001022)1.95920995
127Recurrent pneumonia (HP:0006532)1.95814372
128Mitral stenosis (HP:0001718)1.95296992
129Short nail (HP:0001799)1.94986090
130Abnormal foot bone ossification (HP:0010675)1.94344683
131Obstructive lung disease (HP:0006536)1.94319366
132Chronic obstructive pulmonary disease (HP:0006510)1.94319366
133Recurrent fungal infections (HP:0002841)1.94081363
134Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.93066351
135Vascular calcification (HP:0004934)1.92979705
136Abnormality of the prostate (HP:0008775)1.92067882
137Increased mean platelet volume (HP:0011877)1.91795057
138Lymphoma (HP:0002665)1.91619391
139Chronic bronchitis (HP:0004469)1.91552899
140Glomerulonephritis (HP:0000099)1.91535156
141Late onset (HP:0003584)1.91261076
142Menstrual irregularities (HP:0000858)1.91160971
143Hyperglycemia (HP:0003074)1.90990993
144Enlarged kidneys (HP:0000105)1.90988381
145Papillary thyroid carcinoma (HP:0002895)1.90638752
146Gingival bleeding (HP:0000225)1.89685692
147Abnormality of purine metabolism (HP:0004352)1.89650468
148Amaurosis fugax (HP:0100576)1.89516843
149Emphysema (HP:0002097)1.89227873
150Abnormality of the vasculature of the conjunctiva (HP:0008054)1.88332575
151Aortic dissection (HP:0002647)1.87654902
152Protuberant abdomen (HP:0001538)1.85380126
153Abnormal cartilage morphology (HP:0002763)1.84528266
154Recurrent otitis media (HP:0000403)1.84297812
155Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83942655
156Pancreatitis (HP:0001733)1.83368524
157Verrucae (HP:0200043)1.82861068
158Papilloma (HP:0012740)1.82861068
159Chronic sinusitis (HP:0011109)1.81533734
160Ileus (HP:0002595)1.81025420
161Abnormal platelet volume (HP:0011876)1.80253856
162Metaphyseal dysplasia (HP:0100255)1.80250628
163Spondylolisthesis (HP:0003302)1.80093295
164Leukocytosis (HP:0001974)1.78862071
165Arterial thrombosis (HP:0004420)1.78714058
166Hemorrhage of the eye (HP:0011885)1.78156698
167Global brain atrophy (HP:0002283)1.78132684
168Nephritis (HP:0000123)1.76958259
169Pustule (HP:0200039)1.76938709
170Recurrent lower respiratory tract infections (HP:0002783)1.76757411
171Abnormality of fatty-acid metabolism (HP:0004359)1.75753066
172Male infertility (HP:0003251)1.75694508
173Increased density of long bones (HP:0006392)1.75366411
174Nonimmune hydrops fetalis (HP:0001790)1.75161731
175Spastic diplegia (HP:0001264)1.74060561
176Mucosal telangiectasiae (HP:0100579)1.73909461
177Back pain (HP:0003418)1.70248665
178Symptomatic seizures (HP:0011145)1.70129088
179Polycythemia (HP:0001901)1.70049538
180Abnormality of transition element cation homeostasis (HP:0011030)1.69549783
181Conjugated hyperbilirubinemia (HP:0002908)1.68960512
182Conjunctival telangiectasia (HP:0000524)1.68664434
183Eczematoid dermatitis (HP:0000976)1.68579522
184Subacute progressive viral hepatitis (HP:0006572)1.68034637
185Beaking of vertebral bodies (HP:0004568)1.67526545
186Abnormal enzyme/coenzyme activity (HP:0012379)1.67332132
187Abnormality of methionine metabolism (HP:0010901)1.66968832
188Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66938447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.54163084
2ERN13.99930400
3TRIB33.78251495
4RIPK43.13058948
5PKN22.85369747
6TAOK32.63085576
7SIK12.50728845
8EPHA22.45110097
9BCKDK2.20657278
10TXK2.11541765
11TTN2.10386508
12MYLK2.09452861
13STK242.07869792
14GRK62.05189244
15EIF2AK12.02138694
16LATS11.92441387
17IRAK31.91496959
18FGFR41.89884275
19PTK61.89538933
20FRK1.88899031
21STK101.87780276
22TBK11.80900216
23TYK21.76014925
24PTK2B1.75314879
25SYK1.74504397
26EEF2K1.67641461
27MAP3K31.66732971
28MST1R1.66191081
29TGFBR21.60799233
30LRRK21.60020318
31NLK1.59620442
32BRSK21.55383134
33MAP3K131.52905177
34MAP3K91.51995828
35MAP4K11.49136107
36JAK31.45458777
37FLT31.41048550
38JAK11.37687572
39PLK41.32668096
40MAP4K21.32241024
41NEK91.31687622
42EPHB11.31105157
43ZAP701.27395181
44STK31.25186648
45RPS6KA41.22849512
46RIPK11.20884003
47EPHA31.20450797
48BRAF1.19562573
49DYRK1B1.19405499
50MAP2K31.18910384
51BMPR21.17234382
52ACVR1B1.15995184
53INSRR1.15505602
54TESK11.15151855
55CDK121.14790924
56MAP3K141.14028758
57LYN1.11626850
58MAP3K101.09329888
59PDK41.07730658
60PDK31.07730658
61ARAF1.06998383
62WNK11.06371143
63CAMK1D1.05749223
64FGR1.03775984
65RAF11.03030130
66MELK1.01627977
67PDGFRA1.00894524
68CDK61.00379824
69SCYL21.00120358
70PIK3CG0.99281372
71AKT30.98985679
72EIF2AK30.98465788
73MARK20.97208898
74MAP3K20.96192972
75KIT0.93980339
76PIM20.91014696
77STK38L0.88849249
78DMPK0.88048739
79PRKCQ0.87673975
80TNIK0.87634576
81LMTK20.86785091
82TAF10.86130850
83KSR10.86025929
84PTK20.85671625
85MET0.84876010
86SGK20.84264542
87KSR20.82923845
88ITK0.81382191
89CSF1R0.81324918
90PAK20.80051055
91PLK20.79310116
92JAK20.79022246
93FGFR30.78878056
94ADRBK20.78831631
95BLK0.77921149
96MTOR0.77082738
97BMPR1B0.76255528
98BMX0.75769035
99CSK0.75675726
100GRK50.70882803
101MAP3K80.70842960
102ADRBK10.70138499
103TRPM70.69497743
104CHUK0.68446311
105PAK40.68094920
106PDK20.67085320
107PAK30.65128236
108KDR0.63448749
109SGK30.63327333
110TNK20.62528004
111MAPK150.62276737
112PRKG20.61259510
113SIK30.60663130
114IKBKE0.60235483
115DYRK30.59501685
116HIPK20.59393780
117PDK10.59194274
118BTK0.58998982
119MAPKAPK30.57998151
120IRAK10.57078482
121IRAK40.56926189
122PASK0.56343415
123PDGFRB0.55209142
124IKBKB0.55194425
125HCK0.54859798
126TAOK10.53948099
127ERBB40.52836186
128NUAK10.52048256
129MARK30.50058445
130DDR20.49741122
131MAP3K50.49716928
132FES0.49008945
133TGFBR10.45976466
134NEK60.45247795
135PIM10.45242129
136TEC0.44785314
137RET0.44272692
138PRPF4B0.44055029
139EGFR0.44011355
140CDC42BPA0.43117948
141GSK3A0.42585425
142STK40.42036029
143GRK10.41986685
144MAP3K10.41139834
145MAP2K10.41076451
146MAPK110.40362917
147ABL10.40190026
148IGF1R0.40003316
149PAK10.39973224
150MAP3K70.39889642
151LCK0.39131225
152CDK90.37475025
153CAMK1G0.37349810
154WNK40.36723988
155RPS6KB20.35349768
156MAPKAPK20.35290532

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.96292855
2Platelet activation_Homo sapiens_hsa046112.77555525
3Primary immunodeficiency_Homo sapiens_hsa053402.77324841
4Hematopoietic cell lineage_Homo sapiens_hsa046402.76701977
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.67773049
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.52129440
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.38446917
8Fatty acid degradation_Homo sapiens_hsa000712.37487935
9Selenocompound metabolism_Homo sapiens_hsa004502.34805268
10Complement and coagulation cascades_Homo sapiens_hsa046102.34035243
11Autoimmune thyroid disease_Homo sapiens_hsa053202.33409815
12Allograft rejection_Homo sapiens_hsa053302.23799149
13Graft-versus-host disease_Homo sapiens_hsa053322.19745252
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.14310999
15Caffeine metabolism_Homo sapiens_hsa002322.10482268
16Tryptophan metabolism_Homo sapiens_hsa003802.05333462
17Asthma_Homo sapiens_hsa053102.00168754
18Staphylococcus aureus infection_Homo sapiens_hsa051501.97254602
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.85762373
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84581080
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82728767
22Arginine biosynthesis_Homo sapiens_hsa002201.82447072
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.81562775
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.80659726
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.79345328
26T cell receptor signaling pathway_Homo sapiens_hsa046601.75646832
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.72304750
28PPAR signaling pathway_Homo sapiens_hsa033201.71845342
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.70121150
30Systemic lupus erythematosus_Homo sapiens_hsa053221.63547558
31Propanoate metabolism_Homo sapiens_hsa006401.61892746
32Type I diabetes mellitus_Homo sapiens_hsa049401.60691695
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60188657
34Sulfur metabolism_Homo sapiens_hsa009201.58268617
35Fatty acid metabolism_Homo sapiens_hsa012121.49581131
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47836471
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44484027
38Histidine metabolism_Homo sapiens_hsa003401.41453883
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.37933363
40Peroxisome_Homo sapiens_hsa041461.34892720
41Influenza A_Homo sapiens_hsa051641.34653115
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34153003
43Thyroid cancer_Homo sapiens_hsa052161.29312604
44ABC transporters_Homo sapiens_hsa020101.27827574
45Starch and sucrose metabolism_Homo sapiens_hsa005001.26787580
46Lysosome_Homo sapiens_hsa041421.25035047
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.23313041
48Chemokine signaling pathway_Homo sapiens_hsa040621.22249299
49Viral myocarditis_Homo sapiens_hsa054161.21985361
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18153685
51Viral carcinogenesis_Homo sapiens_hsa052031.18088119
52Chemical carcinogenesis_Homo sapiens_hsa052041.16074777
53Folate biosynthesis_Homo sapiens_hsa007901.10202800
54Herpes simplex infection_Homo sapiens_hsa051681.09932638
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.08992242
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08450981
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07709498
58Fat digestion and absorption_Homo sapiens_hsa049751.06759710
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05886629
60Pyruvate metabolism_Homo sapiens_hsa006200.99856971
61Legionellosis_Homo sapiens_hsa051340.99347764
62Non-small cell lung cancer_Homo sapiens_hsa052230.99054634
63Other glycan degradation_Homo sapiens_hsa005110.99041444
64Carbon metabolism_Homo sapiens_hsa012000.98952563
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98325187
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96540981
67Shigellosis_Homo sapiens_hsa051310.95448013
68Pentose phosphate pathway_Homo sapiens_hsa000300.94969978
69Bile secretion_Homo sapiens_hsa049760.94489350
70Lysine degradation_Homo sapiens_hsa003100.93555960
71Insulin resistance_Homo sapiens_hsa049310.90289042
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90224330
73beta-Alanine metabolism_Homo sapiens_hsa004100.90086462
74Phagosome_Homo sapiens_hsa041450.89729352
75Arachidonic acid metabolism_Homo sapiens_hsa005900.87119775
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.87067920
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86318609
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85509582
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.84176857
80Endocytosis_Homo sapiens_hsa041440.83925724
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83906072
82Leishmaniasis_Homo sapiens_hsa051400.83557242
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83098356
84Biosynthesis of amino acids_Homo sapiens_hsa012300.83000526
85Renal cell carcinoma_Homo sapiens_hsa052110.82268115
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81742680
87Malaria_Homo sapiens_hsa051440.80512039
88Antigen processing and presentation_Homo sapiens_hsa046120.79701181
89Vitamin B6 metabolism_Homo sapiens_hsa007500.79296900
90Retinol metabolism_Homo sapiens_hsa008300.78064841
91Hepatitis B_Homo sapiens_hsa051610.76667079
92Fatty acid biosynthesis_Homo sapiens_hsa000610.76318838
93Toxoplasmosis_Homo sapiens_hsa051450.75965694
94Amoebiasis_Homo sapiens_hsa051460.75435046
95Osteoclast differentiation_Homo sapiens_hsa043800.75322301
96Phenylalanine metabolism_Homo sapiens_hsa003600.75306095
97Tyrosine metabolism_Homo sapiens_hsa003500.74777911
98Endometrial cancer_Homo sapiens_hsa052130.74662908
99One carbon pool by folate_Homo sapiens_hsa006700.74628272
100Adherens junction_Homo sapiens_hsa045200.74313421
101Acute myeloid leukemia_Homo sapiens_hsa052210.73233997
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73075483
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72639085
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72599936
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72535202
106Dorso-ventral axis formation_Homo sapiens_hsa043200.72430616
107Glycerolipid metabolism_Homo sapiens_hsa005610.71435306
108FoxO signaling pathway_Homo sapiens_hsa040680.71266763
109Melanoma_Homo sapiens_hsa052180.70516506
110N-Glycan biosynthesis_Homo sapiens_hsa005100.70449312
111Small cell lung cancer_Homo sapiens_hsa052220.69798936
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69269463
113Prostate cancer_Homo sapiens_hsa052150.69082689
114Circadian rhythm_Homo sapiens_hsa047100.67062213
115ECM-receptor interaction_Homo sapiens_hsa045120.66778859
116Regulation of autophagy_Homo sapiens_hsa041400.66001845
117TNF signaling pathway_Homo sapiens_hsa046680.65516838
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65140718
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.63280799
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62640142
121Pancreatic secretion_Homo sapiens_hsa049720.62263932
122Alcoholism_Homo sapiens_hsa050340.62170616
123Measles_Homo sapiens_hsa051620.60773288
124Vitamin digestion and absorption_Homo sapiens_hsa049770.60381384
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.58975122
126Galactose metabolism_Homo sapiens_hsa000520.57517058
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.57290710
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57202489
129Apoptosis_Homo sapiens_hsa042100.56999334
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55438048
131Bladder cancer_Homo sapiens_hsa052190.55144376
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53740597
133Chronic myeloid leukemia_Homo sapiens_hsa052200.52832048
134Inositol phosphate metabolism_Homo sapiens_hsa005620.52810076
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52084193
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.51667102
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.51148919
138Arginine and proline metabolism_Homo sapiens_hsa003300.50815838
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50634759
140Fructose and mannose metabolism_Homo sapiens_hsa000510.49748534
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49698176
142Pancreatic cancer_Homo sapiens_hsa052120.49617153
143Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48694447
144Hepatitis C_Homo sapiens_hsa051600.48311145
145Pertussis_Homo sapiens_hsa051330.47352546
146Olfactory transduction_Homo sapiens_hsa047400.46678573
147Butanoate metabolism_Homo sapiens_hsa006500.46080699
148Renin-angiotensin system_Homo sapiens_hsa046140.45611196
149Glutathione metabolism_Homo sapiens_hsa004800.45490094
150Focal adhesion_Homo sapiens_hsa045100.45484636
151VEGF signaling pathway_Homo sapiens_hsa043700.45100763
152Proteoglycans in cancer_Homo sapiens_hsa052050.44809916
153Leukocyte transendothelial migration_Homo sapiens_hsa046700.44435469
154Protein export_Homo sapiens_hsa030600.44403844
155Tuberculosis_Homo sapiens_hsa051520.44126196
156Linoleic acid metabolism_Homo sapiens_hsa005910.44033821
157Phototransduction_Homo sapiens_hsa047440.43564724
158RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42631177
159Sphingolipid metabolism_Homo sapiens_hsa006000.42431463
160B cell receptor signaling pathway_Homo sapiens_hsa046620.42206169
161Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39579023
162alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37703504

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