RHBDD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.37704339
2sperm motility (GO:0030317)4.56697013
3L-serine metabolic process (GO:0006563)4.49831783
4peptidyl-histidine modification (GO:0018202)4.41032166
5fusion of sperm to egg plasma membrane (GO:0007342)4.27799815
6peptidyl-arginine omega-N-methylation (GO:0035247)4.24055585
7sperm-egg recognition (GO:0035036)4.19842591
8binding of sperm to zona pellucida (GO:0007339)4.11653445
9histone arginine methylation (GO:0034969)4.02171070
10proteasome assembly (GO:0043248)3.89686278
11pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.84527423
12acrosome reaction (GO:0007340)3.80315045
13motile cilium assembly (GO:0044458)3.78594074
14proline biosynthetic process (GO:0006561)3.69238886
15cullin deneddylation (GO:0010388)3.65980916
16DNA strand elongation involved in DNA replication (GO:0006271)3.64865721
17pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.64157669
18pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.63334942
19base-excision repair, AP site formation (GO:0006285)3.63139569
20CTP metabolic process (GO:0046036)3.62132490
21CTP biosynthetic process (GO:0006241)3.62132490
22cell-cell recognition (GO:0009988)3.60575964
23piRNA metabolic process (GO:0034587)3.59329717
24UTP biosynthetic process (GO:0006228)3.59095028
25axonemal dynein complex assembly (GO:0070286)3.58561889
26GTP biosynthetic process (GO:0006183)3.57038228
27DNA strand elongation (GO:0022616)3.56358039
28pseudouridine synthesis (GO:0001522)3.56006153
29peptidyl-arginine methylation (GO:0018216)3.53980341
30peptidyl-arginine N-methylation (GO:0035246)3.53980341
31tricarboxylic acid cycle (GO:0006099)3.51441214
32spermatid development (GO:0007286)3.46118364
33cilium or flagellum-dependent cell motility (GO:0001539)3.45418006
34regulation of cilium movement (GO:0003352)3.43974562
35GDP-mannose metabolic process (GO:0019673)3.43843157
36guanosine-containing compound biosynthetic process (GO:1901070)3.41014847
37pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.36928106
38telomere maintenance via semi-conservative replication (GO:0032201)3.29741351
39lysine catabolic process (GO:0006554)3.27525602
40lysine metabolic process (GO:0006553)3.27525602
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.25250255
42plasma membrane fusion (GO:0045026)3.24986311
43UTP metabolic process (GO:0046051)3.23560031
44L-methionine salvage (GO:0071267)3.20218859
45L-methionine biosynthetic process (GO:0071265)3.20218859
46amino acid salvage (GO:0043102)3.20218859
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17864099
48valine metabolic process (GO:0006573)3.17052491
49organic cation transport (GO:0015695)3.15577001
50DNA replication initiation (GO:0006270)3.15206856
51Golgi transport vesicle coating (GO:0048200)3.14533100
52COPI coating of Golgi vesicle (GO:0048205)3.14533100
53oxaloacetate metabolic process (GO:0006107)3.13998990
54sulfur amino acid catabolic process (GO:0000098)3.13509302
55chaperone-mediated protein transport (GO:0072321)3.13446813
56cell wall macromolecule catabolic process (GO:0016998)3.13381276
57cell wall macromolecule metabolic process (GO:0044036)3.13381276
58proline metabolic process (GO:0006560)3.13148797
59male meiosis (GO:0007140)3.10451330
60positive regulation of mitochondrial fission (GO:0090141)3.10155607
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.09210476
62L-phenylalanine metabolic process (GO:0006558)3.09210476
63regulation of mitochondrial translation (GO:0070129)3.07502772
64fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.03312973
65mitochondrial RNA metabolic process (GO:0000959)3.02408511
66oxidative phosphorylation (GO:0006119)3.02263933
67polyamine biosynthetic process (GO:0006596)3.01813322
68dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.01280488
69synaptonemal complex organization (GO:0070193)3.00050023
70spliceosomal snRNP assembly (GO:0000387)2.99655657
71tRNA aminoacylation for protein translation (GO:0006418)2.99486101
72negative regulation of ligase activity (GO:0051352)2.98890819
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98890819
74protein targeting to mitochondrion (GO:0006626)2.98542122
75DNA damage response, detection of DNA damage (GO:0042769)2.97813024
76base-excision repair (GO:0006284)2.96703553
77amino-acid betaine metabolic process (GO:0006577)2.96473367
78ribosomal small subunit assembly (GO:0000028)2.94913978
79iron-sulfur cluster assembly (GO:0016226)2.93304384
80metallo-sulfur cluster assembly (GO:0031163)2.93304384
81establishment of protein localization to mitochondrion (GO:0072655)2.92948395
82maturation of 5.8S rRNA (GO:0000460)2.92648587
83L-alpha-amino acid transmembrane transport (GO:1902475)2.92282778
84DNA replication-dependent nucleosome organization (GO:0034723)2.92128269
85DNA replication-dependent nucleosome assembly (GO:0006335)2.92128269
86aspartate family amino acid catabolic process (GO:0009068)2.91981032
87regulation of oxidative phosphorylation (GO:0002082)2.91603910
88water-soluble vitamin biosynthetic process (GO:0042364)2.91468974
89ncRNA 3-end processing (GO:0043628)2.90633258
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.90470476
91L-phenylalanine catabolic process (GO:0006559)2.90470476
92protein insertion into membrane (GO:0051205)2.89345895
93L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88479922
94viral mRNA export from host cell nucleus (GO:0046784)2.87293406
95tRNA aminoacylation (GO:0043039)2.86619459
96amino acid activation (GO:0043038)2.86619459
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.86116148
98tRNA methylation (GO:0030488)2.85997312
99tRNA modification (GO:0006400)2.85906100
100DNA replication checkpoint (GO:0000076)2.85157744
101regulation of cellular amino acid metabolic process (GO:0006521)2.85095601
102deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.84921347
103mitochondrial respiratory chain complex assembly (GO:0033108)2.83571310
104rRNA transcription (GO:0009303)2.83457051
105RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83403663
106tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83403663
107acrosome assembly (GO:0001675)2.83033790
108cytochrome complex assembly (GO:0017004)2.82148452
1092-oxoglutarate metabolic process (GO:0006103)2.80965089
110positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.80037270
111negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.78997454
112pyrimidine nucleoside catabolic process (GO:0046135)2.78873985
113tricarboxylic acid metabolic process (GO:0072350)2.78186510
114glycine metabolic process (GO:0006544)2.77935484
115synaptonemal complex assembly (GO:0007130)2.77243450
116tRNA metabolic process (GO:0006399)2.76099969
117transcription elongation from RNA polymerase III promoter (GO:0006385)2.75863637
118termination of RNA polymerase III transcription (GO:0006386)2.75863637
119sulfur amino acid biosynthetic process (GO:0000097)2.75613593
120mannosylation (GO:0097502)2.75556577
121mitochondrial respiratory chain complex I assembly (GO:0032981)2.74631455
122NADH dehydrogenase complex assembly (GO:0010257)2.74631455
123mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74631455
124tRNA processing (GO:0008033)2.74607220
125protein complex biogenesis (GO:0070271)2.73322775
126epithelial cilium movement (GO:0003351)2.73215239
127nuclear envelope reassembly (GO:0031468)2.73084651
128mitotic nuclear envelope reassembly (GO:0007084)2.73084651
129cysteine metabolic process (GO:0006534)2.72039979
130nucleotide salvage (GO:0043173)2.71723341
131somatic hypermutation of immunoglobulin genes (GO:0016446)2.71615094
132somatic diversification of immune receptors via somatic mutation (GO:0002566)2.71615094
133pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.71613802
134fructose metabolic process (GO:0006000)2.71521464
135alpha-linolenic acid metabolic process (GO:0036109)2.69671109
136establishment of viral latency (GO:0019043)2.69482635
137protein localization to mitochondrion (GO:0070585)2.69306108
138pentose-phosphate shunt (GO:0006098)2.68931506
139negative regulation of mRNA processing (GO:0050686)2.68050231
140serine family amino acid biosynthetic process (GO:0009070)2.66941594
141ribosome biogenesis (GO:0042254)2.66834546
142protein maturation by protein folding (GO:0022417)2.66748066
143chaperone-mediated protein complex assembly (GO:0051131)2.66470603
144carnitine metabolic process (GO:0009437)2.66293411
145glyoxylate metabolic process (GO:0046487)2.66147318
146aldehyde catabolic process (GO:0046185)2.65807523
147transcription-coupled nucleotide-excision repair (GO:0006283)2.65769454
148regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65067070
149regulation of mitotic spindle checkpoint (GO:1903504)2.65067070
150aspartate family amino acid metabolic process (GO:0009066)2.64808210
151anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64157602
152nucleobase biosynthetic process (GO:0046112)2.64151111
153nucleoside salvage (GO:0043174)2.63739888
154cellular metabolic compound salvage (GO:0043094)2.63701666
155polyamine metabolic process (GO:0006595)2.63435759
156aspartate family amino acid biosynthetic process (GO:0009067)2.62093894
157purine nucleobase biosynthetic process (GO:0009113)2.61509058
158DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61095759
159positive regulation of prostaglandin secretion (GO:0032308)2.60904748
160respiratory chain complex IV assembly (GO:0008535)2.59910025
161ubiquinone biosynthetic process (GO:0006744)2.59144611
162methionine biosynthetic process (GO:0009086)2.58227804
163fatty acid beta-oxidation (GO:0006635)2.57106303
164nucleotide-excision repair, DNA gap filling (GO:0006297)2.56873344
165signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.56619018
166signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.56619018
167multicellular organism reproduction (GO:0032504)2.55048305
168triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.54053498
169pyrimidine nucleotide catabolic process (GO:0006244)2.54010728
170methionine metabolic process (GO:0006555)2.53747106
171pteridine-containing compound biosynthetic process (GO:0042559)2.53645629
172formation of translation preinitiation complex (GO:0001731)2.53482949
173glycerol ether metabolic process (GO:0006662)2.53220230
174epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.52615625
175NADH metabolic process (GO:0006734)2.52362531
176maturation of SSU-rRNA (GO:0030490)2.52297178
177regulation of inclusion body assembly (GO:0090083)2.51788102
178protein deneddylation (GO:0000338)2.51765118
1794-hydroxyproline metabolic process (GO:0019471)2.51260681
180low-density lipoprotein particle remodeling (GO:0034374)2.50306251
181inner mitochondrial membrane organization (GO:0007007)2.49195407
182fatty acid catabolic process (GO:0009062)2.49104799
183branched-chain amino acid catabolic process (GO:0009083)2.47987601
184purine nucleotide salvage (GO:0032261)2.47892694
185folic acid-containing compound biosynthetic process (GO:0009396)2.47842833
186seminiferous tubule development (GO:0072520)2.47823560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.18307329
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56521013
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.27465294
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17035807
5* MYC_18555785_ChIP-Seq_MESCs_Mouse2.76385885
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66120778
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61145522
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45087514
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.44319858
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32374244
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.29932950
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.25693557
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.14309274
14YY1_21170310_ChIP-Seq_MESCs_Mouse2.11897309
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.09646851
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.06146863
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.05953378
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.03661649
19GABP_19822575_ChIP-Seq_HepG2_Human1.92198743
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90116710
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88246986
22* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86252393
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85955671
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85437027
25E2F7_22180533_ChIP-Seq_HELA_Human1.85291166
26DCP1A_22483619_ChIP-Seq_HELA_Human1.85148882
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.83586422
28* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83466333
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81797617
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77430113
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71062338
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69065193
33VDR_23849224_ChIP-Seq_CD4+_Human1.68357791
34* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65517937
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63266323
36XRN2_22483619_ChIP-Seq_HELA_Human1.61819814
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59519734
38* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58383907
39* FOXP3_21729870_ChIP-Seq_TREG_Human1.58286249
40YY1_22570637_ChIP-Seq_MALME-3M_Human1.57018956
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56272941
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55436353
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53455201
44* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52076533
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.51932333
46* TET1_21451524_ChIP-Seq_MESCs_Mouse1.51112321
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.48581610
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.47086430
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46572837
50SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.46272732
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42225841
52CIITA_25753668_ChIP-Seq_RAJI_Human1.41274409
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41088268
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41047706
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40993205
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.39486748
57* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35643514
58CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35481116
59* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32936228
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32273927
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31907244
62* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30914940
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29977261
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29679414
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28075787
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27858841
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27825063
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27673288
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27110645
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26537443
71BCL6_27268052_Chip-Seq_Bcells_Human1.24682839
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22988055
73PHF8_20622854_ChIP-Seq_HELA_Human1.22713096
74MYC_18940864_ChIP-ChIP_HL60_Human1.20556780
75* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20267872
76* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19915073
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18408261
78CTCF_26484167_Chip-Seq_Bcells_Mouse1.18347143
79* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16922858
80TFEB_21752829_ChIP-Seq_HELA_Human1.16051002
81MYC_22102868_ChIP-Seq_BL_Human1.15461664
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13839309
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13572155
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13093125
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.13047251
86LXR_22158963_ChIP-Seq_LIVER_Mouse1.12966478
87* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12421346
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11802765
89LXR_22292898_ChIP-Seq_THP-1_Human1.11690255
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11420434
91BCOR_27268052_Chip-Seq_Bcells_Human1.10908878
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.10447196
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09872111
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09587644
95P68_20966046_ChIP-Seq_HELA_Human1.09177022
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08456130
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07312827
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06999432
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06371107
100TTF2_22483619_ChIP-Seq_HELA_Human1.06255550
101HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06242465
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05987906
103LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05790597
104* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05543566
105ZNF263_19887448_ChIP-Seq_K562_Human1.04155632
106RARA_24833708_ChIP-Seq_LIVER_Mouse1.03834854
107NOTCH1_21737748_ChIP-Seq_TLL_Human1.03666033
108VDR_21846776_ChIP-Seq_THP-1_Human1.03535604
109TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02978035
110LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02910862
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02905953
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02565009
113CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02269458
114RARB_24833708_ChIP-Seq_LIVER_Mouse1.02065097
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01866698
116SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01749746
117KDM5A_27292631_Chip-Seq_BREAST_Human1.00937372
118RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99355766
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99206951
120NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99175829
121* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98482471
122FOXP1_21924763_ChIP-Seq_HESCs_Human0.98337334
123FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97115618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.52052096
2MP0002254_reproductive_system_inflammat4.56583999
3MP0003806_abnormal_nucleotide_metabolis4.52288171
4MP0002139_abnormal_hepatobiliary_system4.13071356
5MP0005365_abnormal_bile_salt3.40484190
6MP0005085_abnormal_gallbladder_physiolo3.13495574
7MP0006036_abnormal_mitochondrial_physio2.97485759
8MP0005360_urolithiasis2.73431038
9MP0004133_heterotaxia2.69325903
10MP0003646_muscle_fatigue2.56667747
11MP0008932_abnormal_embryonic_tissue2.55519538
12MP0009840_abnormal_foam_cell2.52257433
13MP0010030_abnormal_orbit_morphology2.44233236
14MP0005670_abnormal_white_adipose2.36046403
15MP0001929_abnormal_gametogenesis2.28095104
16MP0003698_abnormal_male_reproductive2.26708542
17MP0008875_abnormal_xenobiotic_pharmacok2.21634101
18MP0003786_premature_aging2.19640321
19MP0002837_dystrophic_cardiac_calcinosis2.19305937
20MP0003186_abnormal_redox_activity2.11720334
21MP0006035_abnormal_mitochondrial_morpho2.00308702
22MP0001764_abnormal_homeostasis1.94457592
23MP0008007_abnormal_cellular_replicative1.94250814
24MP0005319_abnormal_enzyme/_coenzyme1.91095945
25MP0010329_abnormal_lipoprotein_level1.89891657
26MP0003693_abnormal_embryo_hatching1.87923738
27MP0003195_calcinosis1.85429872
28MP0003656_abnormal_erythrocyte_physiolo1.78881764
29MP0005332_abnormal_amino_acid1.78593722
30MP0001666_abnormal_nutrient_absorption1.77258506
31MP0008789_abnormal_olfactory_epithelium1.77136627
32MP0006292_abnormal_olfactory_placode1.73257315
33MP0002163_abnormal_gland_morphology1.72226064
34MP0000049_abnormal_middle_ear1.68512264
35MP0004043_abnormal_pH_regulation1.65011114
36MP0002269_muscular_atrophy1.63862723
37MP0005083_abnormal_biliary_tract1.61199730
38MP0000358_abnormal_cell_content/1.60324527
39MP0000609_abnormal_liver_physiology1.55656210
40MP0004957_abnormal_blastocyst_morpholog1.53339553
41MP0005499_abnormal_olfactory_system1.52985793
42MP0005394_taste/olfaction_phenotype1.52985793
43MP0004147_increased_porphyrin_level1.52124080
44MP0005636_abnormal_mineral_homeostasis1.50588291
45MP0003252_abnormal_bile_duct1.49559883
46MP0005171_absent_coat_pigmentation1.47553391
47MP0005584_abnormal_enzyme/coenzyme_acti1.47058340
48MP0002132_abnormal_respiratory_system1.46995304
49MP0002938_white_spotting1.46654251
50MP0000751_myopathy1.46628342
51MP0005266_abnormal_metabolism1.44529540
52MP0005058_abnormal_lysosome_morphology1.43414879
53MP0001145_abnormal_male_reproductive1.43039968
54MP0008877_abnormal_DNA_methylation1.38872962
55MP0002102_abnormal_ear_morphology1.38568132
56MP0002210_abnormal_sex_determination1.37023926
57MP0009672_abnormal_birth_weight1.36057703
58MP0002118_abnormal_lipid_homeostasis1.34242234
59MP0003191_abnormal_cellular_cholesterol1.32912363
60MP0002653_abnormal_ependyma_morphology1.32418145
61MP0000749_muscle_degeneration1.29789320
62MP0006072_abnormal_retinal_apoptosis1.29583980
63MP0002736_abnormal_nociception_after1.29340886
64MP0005220_abnormal_exocrine_pancreas1.27581390
65MP0004130_abnormal_muscle_cell1.27117986
66MP0003329_amyloid_beta_deposits1.23136278
67MP0000372_irregular_coat_pigmentation1.21759929
68MP0003878_abnormal_ear_physiology1.20965151
69MP0005377_hearing/vestibular/ear_phenot1.20965151
70MP0002249_abnormal_larynx_morphology1.19914153
71MP0003136_yellow_coat_color1.19299856
72MP0006054_spinal_hemorrhage1.19029455
73MP0003172_abnormal_lysosome_physiology1.18451496
74MP0009643_abnormal_urine_homeostasis1.17370413
75MP0002161_abnormal_fertility/fecundity1.17134285
76MP0008058_abnormal_DNA_repair1.16372690
77MP0002078_abnormal_glucose_homeostasis1.12621709
78MP0008995_early_reproductive_senescence1.12079802
79MP0002970_abnormal_white_adipose1.10534186
80MP0000653_abnormal_sex_gland1.10084525
81MP0003183_abnormal_peptide_metabolism1.04962244
82MP0003868_abnormal_feces_composition1.04673341
83MP0004233_abnormal_muscle_weight1.04084034
84MP0000598_abnormal_liver_morphology1.04078618
85MP0002111_abnormal_tail_morphology1.03755748
86MP0004036_abnormal_muscle_relaxation1.02860934
87MP0010094_abnormal_chromosome_stability1.02474775
88MP0002090_abnormal_vision1.01980111
89MP0001730_embryonic_growth_arrest1.01967750
90MP0001293_anophthalmia1.00444331
91MP0001545_abnormal_hematopoietic_system1.00171499
92MP0005397_hematopoietic_system_phenotyp1.00171499
93MP0002909_abnormal_adrenal_gland0.99033218
94MP0001727_abnormal_embryo_implantation0.98654481
95MP0008260_abnormal_autophagy0.95826616
96MP0005376_homeostasis/metabolism_phenot0.95068865
97MP0003937_abnormal_limbs/digits/tail_de0.94627724
98MP0003111_abnormal_nucleus_morphology0.94175101
99MP0000566_synostosis0.94155983
100MP0001968_abnormal_touch/_nociception0.94068500
101MP0002085_abnormal_embryonic_tissue0.93603805
102MP0003011_delayed_dark_adaptation0.92969594
103MP0004019_abnormal_vitamin_homeostasis0.92222531
104MP0002080_prenatal_lethality0.90804823
105MP0002822_catalepsy0.90672610
106MP0000747_muscle_weakness0.89733242
107MP0001853_heart_inflammation0.89469149
108MP0002693_abnormal_pancreas_physiology0.89151552
109MP0002751_abnormal_autonomic_nervous0.87874661
110MP0008469_abnormal_protein_level0.87247557
111MP0005666_abnormal_adipose_tissue0.85861982
112MP0001944_abnormal_pancreas_morphology0.85152750
113MP0001905_abnormal_dopamine_level0.85139466
114MP0001984_abnormal_olfaction0.84743886
115MP0009642_abnormal_blood_homeostasis0.82940907
116MP0005330_cardiomyopathy0.82017891
117MP0003122_maternal_imprinting0.81821694
118MP0000647_abnormal_sebaceous_gland0.81465592
119MP0005647_abnormal_sex_gland0.80801699
120MP0000003_abnormal_adipose_tissue0.80603035
121MP0002089_abnormal_postnatal_growth/wei0.80115740
122MP0004215_abnormal_myocardial_fiber0.79710617
123MP0000750_abnormal_muscle_regeneration0.79496363
124MP0002084_abnormal_developmental_patter0.79483435
125MP0009278_abnormal_bone_marrow0.79455688
126MP0005379_endocrine/exocrine_gland_phen0.79366280
127MP0000350_abnormal_cell_proliferation0.78936293
128MP0003137_abnormal_impulse_conducting0.78851388
129MP0001119_abnormal_female_reproductive0.77942653
130MP0001346_abnormal_lacrimal_gland0.77475987
131MP0003718_maternal_effect0.77475582
132MP0002234_abnormal_pharynx_morphology0.76357414
133MP0003077_abnormal_cell_cycle0.76204602
134MP0003879_abnormal_hair_cell0.76169119
135MP0001529_abnormal_vocalization0.76079166
136MP0008057_abnormal_DNA_replication0.75910374
137MP0009697_abnormal_copulation0.75902692
138MP0004145_abnormal_muscle_electrophysio0.75571612
139MP0009333_abnormal_splenocyte_physiolog0.75526890
140MP0004264_abnormal_extraembryonic_tissu0.75522938
141MP0000026_abnormal_inner_ear0.75048743
142MP0002971_abnormal_brown_adipose0.75015904
143MP0000604_amyloidosis0.74749550
144MP0001697_abnormal_embryo_size0.74747687
145MP0002160_abnormal_reproductive_system0.73998677
146MP0005253_abnormal_eye_physiology0.73477077
147MP0001672_abnormal_embryogenesis/_devel0.73236043
148MP0005380_embryogenesis_phenotype0.73236043
149MP0000313_abnormal_cell_death0.71761815
150MP0005334_abnormal_fat_pad0.71693642
151MP0005389_reproductive_system_phenotype0.71586141
152MP0001661_extended_life_span0.71144164
153MP0005451_abnormal_body_composition0.70840525
154MP0004858_abnormal_nervous_system0.70594703
155MP0002233_abnormal_nose_morphology0.70436182
156MP0003953_abnormal_hormone_level0.70413764
157MP0005501_abnormal_skin_physiology0.69837431
158MP0004197_abnormal_fetal_growth/weight/0.69600924
159MP0005448_abnormal_energy_balance0.69184874
160MP0003075_altered_response_to0.68668810
161MP0000678_abnormal_parathyroid_gland0.67361014
162MP0001849_ear_inflammation0.66764795
163MP0005535_abnormal_body_temperature0.66552302

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.28870875
2Chronic bronchitis (HP:0004469)4.14182905
3Nasal polyposis (HP:0100582)3.60609375
4Absent/shortened dynein arms (HP:0200106)3.51178610
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.51178610
6Hepatic necrosis (HP:0002605)3.51006636
7Myoglobinuria (HP:0002913)3.41982752
8Late onset (HP:0003584)3.41394515
9Ketosis (HP:0001946)3.39689038
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.39492564
11Hepatocellular necrosis (HP:0001404)3.22769390
12Abnormal mitochondria in muscle tissue (HP:0008316)3.22748673
13Progressive muscle weakness (HP:0003323)3.17431985
14Ketoacidosis (HP:0001993)3.17328831
15Abnormality of dicarboxylic acid metabolism (HP:0010995)3.14240235
16Dicarboxylic aciduria (HP:0003215)3.14240235
17Hypoglycemic coma (HP:0001325)3.12471610
18Abnormality of the nasal mucosa (HP:0000433)3.09721271
19Acute necrotizing encephalopathy (HP:0006965)3.02810185
20Acute encephalopathy (HP:0006846)3.01444731
21Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.94135399
22Abnormality of alanine metabolism (HP:0010916)2.94090222
23Hyperalaninemia (HP:0003348)2.94090222
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.94090222
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92643475
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92643475
27Increased muscle lipid content (HP:0009058)2.90830340
28Ragged-red muscle fibers (HP:0003200)2.89477358
29Multiple enchondromatosis (HP:0005701)2.89047088
30Mitochondrial inheritance (HP:0001427)2.83221206
31Lactic acidosis (HP:0003128)2.83196397
32Cerebral edema (HP:0002181)2.80170699
33Degeneration of anterior horn cells (HP:0002398)2.75604403
34Abnormality of the anterior horn cell (HP:0006802)2.75604403
35Generalized aminoaciduria (HP:0002909)2.75251499
36Rhinitis (HP:0012384)2.73466887
37Hyperammonemia (HP:0001987)2.70205931
38Abnormality of fatty-acid metabolism (HP:0004359)2.68858847
39Increased CSF lactate (HP:0002490)2.67189828
40Abnormal respiratory epithelium morphology (HP:0012253)2.64701159
41Abnormal respiratory motile cilium morphology (HP:0005938)2.64701159
42Microretrognathia (HP:0000308)2.64452311
43Rhabdomyolysis (HP:0003201)2.61714459
44Testicular atrophy (HP:0000029)2.57558429
45Increased intramyocellular lipid droplets (HP:0012240)2.56127837
46Abnormal respiratory motile cilium physiology (HP:0012261)2.54117383
47Increased serum lactate (HP:0002151)2.49206563
48Exercise-induced myalgia (HP:0003738)2.48428413
49Asymmetric septal hypertrophy (HP:0001670)2.48360275
50Bronchitis (HP:0012387)2.48256714
51Infertility (HP:0000789)2.47088706
52Aplastic anemia (HP:0001915)2.46421819
53Hyperinsulinemic hypoglycemia (HP:0000825)2.44593802
54Increased neuronal autofluorescent lipopigment (HP:0002074)2.40041171
55Abnormality of the lower motor neuron (HP:0002366)2.35585079
56Poikiloderma (HP:0001029)2.34953695
57Lethargy (HP:0001254)2.33856536
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31412185
59Abnormal protein N-linked glycosylation (HP:0012347)2.31412185
60Abnormal protein glycosylation (HP:0012346)2.31412185
61Abnormal glycosylation (HP:0012345)2.31412185
62Hyperglycinuria (HP:0003108)2.31382890
63Pendular nystagmus (HP:0012043)2.30700266
64Reduced antithrombin III activity (HP:0001976)2.28298728
65Abnormal number of erythroid precursors (HP:0012131)2.27834627
66Hypobetalipoproteinemia (HP:0003563)2.27123847
67Abnormality of monocarboxylic acid metabolism (HP:0010996)2.26274652
68Increased cerebral lipofuscin (HP:0011813)2.24645487
69Hypokinesia (HP:0002375)2.23920830
70Palpitations (HP:0001962)2.23703391
71Abnormality of the intrinsic pathway (HP:0010989)2.22439426
72Abnormality of cells of the erythroid lineage (HP:0012130)2.22235862
73Thrombocytosis (HP:0001894)2.21772674
74Brushfield spots (HP:0001088)2.21124260
75Hyperbilirubinemia (HP:0002904)2.20877780
76Type I transferrin isoform profile (HP:0003642)2.20184302
77Abnormality of the labia minora (HP:0012880)2.18606201
78Methylmalonic aciduria (HP:0012120)2.16913112
79Broad distal phalanx of finger (HP:0009836)2.16875587
80Progressive macrocephaly (HP:0004481)2.14703727
81Intrahepatic cholestasis (HP:0001406)2.14508062
82Emotional lability (HP:0000712)2.14219929
83CNS demyelination (HP:0007305)2.13789286
84Cholecystitis (HP:0001082)2.13420382
85Abnormal gallbladder physiology (HP:0012438)2.13420382
86Xanthomatosis (HP:0000991)2.13165091
873-Methylglutaconic aciduria (HP:0003535)2.12822945
88Vacuolated lymphocytes (HP:0001922)2.12508025
89Stridor (HP:0010307)2.11448284
90Horseshoe kidney (HP:0000085)2.09748732
91Exercise intolerance (HP:0003546)2.09665007
92Hyperlipoproteinemia (HP:0010980)2.08767228
93Squamous cell carcinoma (HP:0002860)2.08763690
94Hypoplasia of the pons (HP:0012110)2.07875141
95Metabolic acidosis (HP:0001942)2.07007249
96Microvesicular hepatic steatosis (HP:0001414)2.05777779
97Abnormality of the heme biosynthetic pathway (HP:0010472)2.05001493
98Abnormal spermatogenesis (HP:0008669)2.03394948
99Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03073710
100Abnormality of serum amino acid levels (HP:0003112)1.99655755
101Colon cancer (HP:0003003)1.98810056
102Abnormality of sulfur amino acid metabolism (HP:0004339)1.98414936
103Gout (HP:0001997)1.97447387
104Progressive microcephaly (HP:0000253)1.97203431
105Tinnitus (HP:0000360)1.96423178
106Truncus arteriosus (HP:0001660)1.96031796
107Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95791852
108Neuroendocrine neoplasm (HP:0100634)1.95485054
109Vomiting (HP:0002013)1.95425855
110Opisthotonus (HP:0002179)1.95180469
111Entropion (HP:0000621)1.95122126
112Facial cleft (HP:0002006)1.94274758
113Hyperglycinemia (HP:0002154)1.93505826
114Abnormality of serine family amino acid metabolism (HP:0010894)1.91733396
115Abnormality of glycine metabolism (HP:0010895)1.91733396
116Abnormality of methionine metabolism (HP:0010901)1.91691101
117Lipid accumulation in hepatocytes (HP:0006561)1.91582116
118Poor suck (HP:0002033)1.91302301
119Hypolipoproteinemia (HP:0010981)1.89834879
120Poor head control (HP:0002421)1.89720225
121Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89698439
122Abnormality of liposaccharide metabolism (HP:0010968)1.87905394
123Abnormality of glycosphingolipid metabolism (HP:0004343)1.87905394
124Abnormality of glycolipid metabolism (HP:0010969)1.87905394
125Spastic diplegia (HP:0001264)1.87797761
126Aplasia/Hypoplasia of the patella (HP:0006498)1.86516981
127Synostosis involving the elbow (HP:0003938)1.85819389
128Humeroradial synostosis (HP:0003041)1.85819389
129Absent epiphyses (HP:0010577)1.85224478
130Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85224478
131Increased serum pyruvate (HP:0003542)1.85133894
132Abnormality of glycolysis (HP:0004366)1.85133894
133Abnormal number of incisors (HP:0011064)1.84844219
134Pancytopenia (HP:0001876)1.84565712
135Respiratory failure (HP:0002878)1.83616616
136Rough bone trabeculation (HP:0100670)1.82621487
137Hyperacusis (HP:0010780)1.82112581
138Delayed CNS myelination (HP:0002188)1.80962274
139Overriding aorta (HP:0002623)1.80504987
140Hypoplastic pelvis (HP:0008839)1.80213075
141Hypoalphalipoproteinemia (HP:0003233)1.79196096
142Prolonged neonatal jaundice (HP:0006579)1.78985220
143Ependymoma (HP:0002888)1.78899387
144Optic nerve coloboma (HP:0000588)1.77298946
145Retinal dysplasia (HP:0007973)1.77111312
146Abnormality of the pons (HP:0007361)1.75450983
147Patellar aplasia (HP:0006443)1.74879861
148Aplasia/Hypoplasia of the spleen (HP:0010451)1.74817727
149Death in infancy (HP:0001522)1.70274070
150Mesangial abnormality (HP:0001966)1.70149611
151Tongue fasciculations (HP:0001308)1.69003556
152Meckel diverticulum (HP:0002245)1.68226013
153Decreased electroretinogram (ERG) amplitude (HP:0000654)1.66498919
154Polyphagia (HP:0002591)1.65308202
155Preaxial hand polydactyly (HP:0001177)1.64999362
156Hand muscle atrophy (HP:0009130)1.63956436
157Spastic paraparesis (HP:0002313)1.62728009
158Abnormality of dental color (HP:0011073)1.62531132

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.66549142
2PDK34.66549142
3STK164.62965435
4BCKDK4.37932035
5ERN13.83399208
6VRK23.47099661
7TESK13.14982587
8SMG13.10685471
9PASK2.73417800
10TRIB32.69935294
11PDK22.59797187
12SRPK12.56656681
13ICK2.39044475
14FLT32.27062139
15MAP4K22.25950280
16ZAK2.25796394
17CSNK1G32.12774372
18IRAK31.99139051
19PKN21.95617922
20SCYL21.92154332
21NME21.78124277
22WEE11.77534961
23CSNK1A1L1.69834067
24CSNK1G11.65929251
25TRIM281.63469906
26NEK11.57616123
27CSNK1G21.54240889
28MUSK1.52904786
29PRKD31.47831208
30PIM21.46053900
31MAP2K71.45994487
32NEK21.41293288
33ARAF1.40516847
34LIMK11.39708766
35BUB11.32858897
36MAP3K111.32513363
37EIF2AK11.23561767
38VRK11.21789743
39PBK1.21778731
40MAPKAPK31.21443236
41EEF2K1.20621261
42EIF2AK31.20599526
43BRAF1.19671766
44MAP2K31.16034491
45LMTK21.15034751
46RPS6KA51.13947072
47DYRK31.13342011
48MAP4K11.10963120
49SIK11.07697150
50ZAP701.07211275
51PLK41.05448210
52MAPK151.05046594
53ABL21.04464209
54BRSK21.03862445
55TESK21.02898730
56PINK10.98214159
57NUAK10.96459913
58PRKCI0.96387860
59MAP3K100.94107386
60TLK10.93188485
61PLK30.91504774
62GRK60.91370085
63DAPK10.90597871
64TBK10.88949729
65TNK20.88288517
66NME10.87944187
67KDR0.86025916
68CDC70.82588682
69CHEK10.82224549
70CDK40.79861511
71CSF1R0.76698473
72IRAK20.75104731
73MAP3K30.74243205
74KIT0.74106484
75ACVR1B0.73196340
76PAK40.72938629
77BTK0.72620145
78PHKG10.68215786
79PHKG20.68215786
80AKT20.66973910
81MKNK10.66553334
82DAPK30.63718598
83WNK40.63503432
84MYLK0.63469009
85CCNB10.62000357
86TYK20.61595013
87WNK30.61359208
88PKN10.60175512
89CDK90.59081234
90CDK190.59003268
91ATR0.58217044
92CSNK1A10.57943874
93CDK70.57774912
94MAP3K40.57645219
95RPS6KB20.56938180
96AURKA0.56212467
97PLK10.55382813
98BCR0.55032123
99RPS6KL10.54992871
100RPS6KC10.54992871
101TSSK60.51735053
102RPS6KA20.50529782
103MAP2K60.50058165
104DYRK1B0.50018236
105PRKD20.49661246
106EPHA20.49446478
107ATM0.49000400
108CAMKK10.48220024
109PTK2B0.48115722
110MATK0.46850238
111RPS6KA10.46457488
112RPS6KA60.45814636
113PAK60.44886482
114PTK60.44778133
115CAMK1D0.44384121
116CDK20.43823222
117OBSCN0.43619067
118ILK0.43011131
119IKBKB0.42431134
120CDK10.42033375
121CDK11A0.40975628
122RPS6KA40.40974551
123TAF10.40756170
124TTK0.40153411
125TAOK20.38508171
126MAPK110.37542163
127PAK10.37266949
128CAMK2G0.36824213
129MAP2K20.36090796
130ADRBK20.35379202
131OXSR10.35200277
132CDK140.34627224
133CSNK2A10.34597053
134BRSK10.34313823
135TGFBR10.34113746
136MAP3K80.34068384
137PRKG20.33936638
138TTN0.32725340
139TAOK10.32625936
140PIK3CG0.32244278
141CAMKK20.31386567
142GRK50.31211430
143CSNK2A20.31178036
144SYK0.30318829
145HIPK20.29893829
146PDK10.29876872
147MTOR0.29592736
148RIPK10.28154204
149AURKB0.24251543
150PRKAA10.23846928
151CDK80.22740809
152CHEK20.22446807
153MAPK120.21932903
154DYRK20.21864617

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.19679002
2Selenocompound metabolism_Homo sapiens_hsa004502.73550167
3Fatty acid degradation_Homo sapiens_hsa000712.48725472
4Sulfur relay system_Homo sapiens_hsa041222.40805975
5Pyruvate metabolism_Homo sapiens_hsa006202.40004014
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.39177768
7Propanoate metabolism_Homo sapiens_hsa006402.39164525
8Carbon metabolism_Homo sapiens_hsa012002.26428396
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.25772570
10Pentose phosphate pathway_Homo sapiens_hsa000302.15812441
11Biosynthesis of amino acids_Homo sapiens_hsa012302.13403330
12Cysteine and methionine metabolism_Homo sapiens_hsa002702.11452321
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.05701039
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.95673607
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92193784
16DNA replication_Homo sapiens_hsa030301.90483058
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.89577041
18Proteasome_Homo sapiens_hsa030501.87100883
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85011268
20Fatty acid metabolism_Homo sapiens_hsa012121.80671152
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.77863688
22Protein export_Homo sapiens_hsa030601.76393780
23Oxidative phosphorylation_Homo sapiens_hsa001901.74981237
24Fructose and mannose metabolism_Homo sapiens_hsa000511.71532120
25Non-homologous end-joining_Homo sapiens_hsa034501.67425266
26Parkinsons disease_Homo sapiens_hsa050121.64381497
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64109339
28Ribosome_Homo sapiens_hsa030101.63798121
29Pyrimidine metabolism_Homo sapiens_hsa002401.59991598
30Folate biosynthesis_Homo sapiens_hsa007901.57032716
31N-Glycan biosynthesis_Homo sapiens_hsa005101.55797014
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55647367
33Peroxisome_Homo sapiens_hsa041461.53996145
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46183767
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45383006
36Steroid biosynthesis_Homo sapiens_hsa001001.45284209
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39701914
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36923501
39Tryptophan metabolism_Homo sapiens_hsa003801.34918636
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.29403167
41Base excision repair_Homo sapiens_hsa034101.26274296
42Fat digestion and absorption_Homo sapiens_hsa049751.24156637
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24071954
44Huntingtons disease_Homo sapiens_hsa050161.22809948
45PPAR signaling pathway_Homo sapiens_hsa033201.21746383
46Mismatch repair_Homo sapiens_hsa034301.20893122
47Sulfur metabolism_Homo sapiens_hsa009201.19301299
48Galactose metabolism_Homo sapiens_hsa000521.18594677
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16180683
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14654900
51RNA degradation_Homo sapiens_hsa030181.14472844
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08062241
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01077620
54Metabolic pathways_Homo sapiens_hsa011001.00437723
55Glycerolipid metabolism_Homo sapiens_hsa005610.99887542
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99770847
57One carbon pool by folate_Homo sapiens_hsa006700.98223407
58Collecting duct acid secretion_Homo sapiens_hsa049660.96707150
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96426459
60Fatty acid biosynthesis_Homo sapiens_hsa000610.95077764
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.94992780
62Nucleotide excision repair_Homo sapiens_hsa034200.93833622
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92155621
64Butanoate metabolism_Homo sapiens_hsa006500.91407289
65Alzheimers disease_Homo sapiens_hsa050100.90471902
66Arginine and proline metabolism_Homo sapiens_hsa003300.89630547
67Purine metabolism_Homo sapiens_hsa002300.87687646
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87555786
69Homologous recombination_Homo sapiens_hsa034400.86999930
70Lysosome_Homo sapiens_hsa041420.85725345
71Linoleic acid metabolism_Homo sapiens_hsa005910.82902563
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.81998284
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81865533
74Fatty acid elongation_Homo sapiens_hsa000620.81818784
75Cell cycle_Homo sapiens_hsa041100.81786255
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81237717
77RNA polymerase_Homo sapiens_hsa030200.80311926
78Starch and sucrose metabolism_Homo sapiens_hsa005000.80163119
79Arginine biosynthesis_Homo sapiens_hsa002200.80014215
80mRNA surveillance pathway_Homo sapiens_hsa030150.79312643
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78654956
82Vitamin B6 metabolism_Homo sapiens_hsa007500.76956028
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76931272
84Phenylalanine metabolism_Homo sapiens_hsa003600.75275039
85ABC transporters_Homo sapiens_hsa020100.71518347
86Glucagon signaling pathway_Homo sapiens_hsa049220.70218270
87RNA transport_Homo sapiens_hsa030130.70196983
88Cardiac muscle contraction_Homo sapiens_hsa042600.69210085
89beta-Alanine metabolism_Homo sapiens_hsa004100.68051890
90Spliceosome_Homo sapiens_hsa030400.66123333
91Glutathione metabolism_Homo sapiens_hsa004800.65163959
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64494174
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63465579
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.59638868
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57822167
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56573810
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56273959
98Basal cell carcinoma_Homo sapiens_hsa052170.54696937
99Chemical carcinogenesis_Homo sapiens_hsa052040.53941838
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53551087
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52541934
102Sphingolipid metabolism_Homo sapiens_hsa006000.51462789
103Tyrosine metabolism_Homo sapiens_hsa003500.50481522
104Bile secretion_Homo sapiens_hsa049760.50394856
105p53 signaling pathway_Homo sapiens_hsa041150.50062454
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47540631
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47098628
108Complement and coagulation cascades_Homo sapiens_hsa046100.46709779
109Synaptic vesicle cycle_Homo sapiens_hsa047210.45940865
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.45342259
111Vitamin digestion and absorption_Homo sapiens_hsa049770.42036001
112Basal transcription factors_Homo sapiens_hsa030220.41992332
113Renin-angiotensin system_Homo sapiens_hsa046140.41550777
114Other glycan degradation_Homo sapiens_hsa005110.41108381
115Regulation of autophagy_Homo sapiens_hsa041400.40988537
116Histidine metabolism_Homo sapiens_hsa003400.39392232
117Ether lipid metabolism_Homo sapiens_hsa005650.38324850
118Lysine degradation_Homo sapiens_hsa003100.37368255
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34736481
120Vibrio cholerae infection_Homo sapiens_hsa051100.34031947
121Fanconi anemia pathway_Homo sapiens_hsa034600.34031083
122Bladder cancer_Homo sapiens_hsa052190.33840892
123Retinol metabolism_Homo sapiens_hsa008300.33280871
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32550105
125Phototransduction_Homo sapiens_hsa047440.23930794
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23656976

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