

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | hemidesmosome assembly (GO:0031581) | 5.35455620 |
| 2 | protein heterotrimerization (GO:0070208) | 4.94317798 |
| 3 | collagen fibril organization (GO:0030199) | 4.23608614 |
| 4 | semaphorin-plexin signaling pathway (GO:0071526) | 4.23171378 |
| 5 | skin morphogenesis (GO:0043589) | 4.22105041 |
| 6 | Golgi transport vesicle coating (GO:0048200) | 4.14830157 |
| 7 | COPI coating of Golgi vesicle (GO:0048205) | 4.14830157 |
| 8 | desmosome organization (GO:0002934) | 4.03073395 |
| 9 | basement membrane organization (GO:0071711) | 4.00976019 |
| 10 | plasma membrane repair (GO:0001778) | 3.95191481 |
| 11 | epithelial cell-cell adhesion (GO:0090136) | 3.86586342 |
| 12 | endodermal cell differentiation (GO:0035987) | 3.84935352 |
| 13 | protein retention in ER lumen (GO:0006621) | 3.79107721 |
| 14 | cell-substrate junction assembly (GO:0007044) | 3.71049116 |
| 15 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 3.69833713 |
| 16 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 3.68265752 |
| 17 | collagen metabolic process (GO:0032963) | 3.50014657 |
| 18 | chondrocyte proliferation (GO:0035988) | 3.46199993 |
| 19 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 3.45163939 |
| 20 | bone trabecula formation (GO:0060346) | 3.43290428 |
| 21 | collagen catabolic process (GO:0030574) | 3.41243928 |
| 22 | multicellular organismal macromolecule metabolic process (GO:0044259) | 3.33330892 |
| 23 | endothelial cell chemotaxis (GO:0035767) | 3.30871745 |
| 24 | cell adhesion mediated by integrin (GO:0033627) | 3.30322947 |
| 25 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 3.29407126 |
| 26 | negative regulation of chondrocyte differentiation (GO:0032331) | 3.29365900 |
| 27 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 3.29087969 |
| 28 | axon extension involved in axon guidance (GO:0048846) | 3.29087969 |
| 29 | establishment of apical/basal cell polarity (GO:0035089) | 3.28548823 |
| 30 | extracellular matrix disassembly (GO:0022617) | 3.25728808 |
| 31 | vascular endothelial growth factor signaling pathway (GO:0038084) | 3.25671459 |
| 32 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 3.25637251 |
| 33 | atrioventricular valve morphogenesis (GO:0003181) | 3.25364286 |
| 34 | multicellular organismal catabolic process (GO:0044243) | 3.23849903 |
| 35 | regulation of hippo signaling (GO:0035330) | 3.22702561 |
| 36 | polarized epithelial cell differentiation (GO:0030859) | 3.22571962 |
| 37 | multicellular organismal metabolic process (GO:0044236) | 3.22423844 |
| 38 | wound healing, spreading of epidermal cells (GO:0035313) | 3.22297756 |
| 39 | branching involved in salivary gland morphogenesis (GO:0060445) | 3.21537591 |
| 40 | paraxial mesoderm development (GO:0048339) | 3.18562670 |
| 41 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.17982125 |
| 42 | hippo signaling (GO:0035329) | 3.16779810 |
| 43 | type B pancreatic cell proliferation (GO:0044342) | 3.16717405 |
| 44 | endothelial cell morphogenesis (GO:0001886) | 3.15589982 |
| 45 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 3.13643132 |
| 46 | vascular endothelial growth factor receptor signaling pathway (GO:0048010) | 3.11646762 |
| 47 | regulation of establishment of planar polarity (GO:0090175) | 3.11618749 |
| 48 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 3.11187455 |
| 49 | convergent extension (GO:0060026) | 3.10506792 |
| 50 | positive regulation of blood vessel endothelial cell migration (GO:0043536) | 3.10318180 |
| 51 | glomerular basement membrane development (GO:0032836) | 3.02874973 |
| 52 | renal filtration (GO:0097205) | 3.02222576 |
| 53 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 3.02066967 |
| 54 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 3.00095874 |
| 55 | cellular response to vascular endothelial growth factor stimulus (GO:0035924) | 2.99939475 |
| 56 | adherens junction assembly (GO:0034333) | 2.98130963 |
| 57 | negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067) | 2.96567113 |
| 58 | branching involved in mammary gland duct morphogenesis (GO:0060444) | 2.91166802 |
| 59 | negative regulation of fatty acid transport (GO:2000192) | 2.89768682 |
| 60 | endocardial cushion development (GO:0003197) | 2.89266603 |
| 61 | apoptotic cell clearance (GO:0043277) | 2.88562237 |
| 62 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 2.88524365 |
| 63 | negative regulation of cell size (GO:0045792) | 2.88500357 |
| 64 | regulation of branching involved in prostate gland morphogenesis (GO:0060687) | 2.86217219 |
| 65 | negative regulation of smooth muscle cell migration (GO:0014912) | 2.86151762 |
| 66 | cochlea morphogenesis (GO:0090103) | 2.85931984 |
| 67 | positive regulation of osteoblast proliferation (GO:0033690) | 2.85454665 |
| 68 | outer ear morphogenesis (GO:0042473) | 2.85303302 |
| 69 | peptidyl-proline hydroxylation (GO:0019511) | 2.81821439 |
| 70 | negative regulation of cartilage development (GO:0061037) | 2.81706417 |
| 71 | muscle cell migration (GO:0014812) | 2.79183994 |
| 72 | cell migration involved in sprouting angiogenesis (GO:0002042) | 2.77622048 |
| 73 | glomerular visceral epithelial cell development (GO:0072015) | 2.75608254 |
| 74 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.75333172 |
| 75 | pattern specification involved in kidney development (GO:0061004) | 2.74095495 |
| 76 | negative regulation of catenin import into nucleus (GO:0035414) | 2.73720161 |
| 77 | wound healing, spreading of cells (GO:0044319) | 2.71396205 |
| 78 | protein localization to endosome (GO:0036010) | 2.71058603 |
| 79 | protein hydroxylation (GO:0018126) | 2.68254798 |
| 80 | substrate-dependent cell migration (GO:0006929) | 2.68041252 |
| 81 | regulation of early endosome to late endosome transport (GO:2000641) | 2.67086610 |
| 82 | cardiac myofibril assembly (GO:0055003) | 2.66798090 |
| 83 | renal system development (GO:0072001) | 2.66578799 |
| 84 | glomerular filtration (GO:0003094) | 2.66564257 |
| 85 | regulation of cardioblast differentiation (GO:0051890) | 2.66388059 |
| 86 | sequestering of extracellular ligand from receptor (GO:0035581) | 2.66109357 |
| 87 | barbed-end actin filament capping (GO:0051016) | 2.65691017 |
| 88 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.65218153 |
| 89 | non-canonical Wnt signaling pathway (GO:0035567) | 2.65139748 |
| 90 | kidney mesenchyme development (GO:0072074) | 2.64407075 |
| 91 | substrate adhesion-dependent cell spreading (GO:0034446) | 2.64202896 |
| 92 | positive regulation of epithelial to mesenchymal transition (GO:0010718) | 2.64153321 |
| 93 | mesodermal cell differentiation (GO:0048333) | 2.64008000 |
| 94 | extracellular matrix assembly (GO:0085029) | 2.61134014 |
| 95 | establishment of monopolar cell polarity (GO:0061162) | 2.60931685 |
| 96 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 2.60931685 |
| 97 | endocytic recycling (GO:0032456) | 2.60363541 |
| 98 | collecting duct development (GO:0072044) | 2.60059694 |
| 99 | tooth mineralization (GO:0034505) | 2.59694100 |
| 100 | negative regulation of axon extension involved in axon guidance (GO:0048843) | 2.59488039 |
| 101 | positive regulation of receptor recycling (GO:0001921) | 2.58299502 |
| 102 | mannose metabolic process (GO:0006013) | 2.58070966 |
| 103 | activation of Rac GTPase activity (GO:0032863) | 2.57912576 |
| 104 | notochord development (GO:0030903) | 2.57016439 |
| 105 | stress fiber assembly (GO:0043149) | 2.56891694 |
| 106 | regulation of glucose import in response to insulin stimulus (GO:2001273) | 2.56510278 |
| 107 | fibroblast migration (GO:0010761) | 2.55832714 |
| 108 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 2.55645227 |
| 109 | regulation of tight junction assembly (GO:2000810) | 2.53463226 |
| 110 | sarcomere organization (GO:0045214) | 2.52617833 |
| 111 | apoptotic process involved in morphogenesis (GO:0060561) | 2.52151426 |
| 112 | regulation of heart morphogenesis (GO:2000826) | 2.50364958 |
| 113 | extracellular matrix organization (GO:0030198) | 2.49975757 |
| 114 | protein localization to cell surface (GO:0034394) | 2.49888383 |
| 115 | cellular response to vitamin (GO:0071295) | 2.49715160 |
| 116 | adhesion of symbiont to host cell (GO:0044650) | 2.49323579 |
| 117 | virion attachment to host cell (GO:0019062) | 2.49323579 |
| 118 | focal adhesion assembly (GO:0048041) | 2.49243120 |
| 119 | cell-substrate adherens junction assembly (GO:0007045) | 2.49243120 |
| 120 | cell-cell junction maintenance (GO:0045217) | 2.49226256 |
| 121 | negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037) | 2.49028119 |
| 122 | extracellular structure organization (GO:0043062) | 2.48837518 |
| 123 | trabecula formation (GO:0060343) | 2.48473105 |
| 124 | heart valve morphogenesis (GO:0003179) | 2.47821552 |
| 125 | positive regulation of cartilage development (GO:0061036) | 2.46668400 |
| 126 | blood vessel maturation (GO:0001955) | 2.46520424 |
| 127 | regulation of p38MAPK cascade (GO:1900744) | 2.46485889 |
| 128 | aorta morphogenesis (GO:0035909) | 2.45785719 |
| 129 | maternal placenta development (GO:0001893) | 2.45211302 |
| 130 | growth hormone receptor signaling pathway (GO:0060396) | 2.45030375 |
| 131 | glomerular epithelial cell development (GO:0072310) | 2.44735076 |
| 132 | blood vessel endothelial cell migration (GO:0043534) | 2.43815582 |
| 133 | ectoderm development (GO:0007398) | 2.43645963 |
| 134 | cell migration involved in heart development (GO:0060973) | 2.43603367 |
| 135 | negative regulation of adherens junction organization (GO:1903392) | 2.43120483 |
| 136 | negative regulation of focal adhesion assembly (GO:0051895) | 2.43120483 |
| 137 | negative regulation of cell junction assembly (GO:1901889) | 2.43120483 |
| 138 | craniofacial suture morphogenesis (GO:0097094) | 2.42760147 |
| 139 | cell proliferation involved in metanephros development (GO:0072203) | 2.42493875 |
| 140 | regulation of SMAD protein import into nucleus (GO:0060390) | 2.41225657 |
| 141 | mesenchyme morphogenesis (GO:0072132) | 2.41179362 |
| 142 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 2.40585299 |
| 143 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr | 2.40344887 |
| 144 | lymphangiogenesis (GO:0001946) | 2.40131181 |
| 145 | negative regulation of cell fate specification (GO:0009996) | 2.40090191 |
| 146 | coronary vasculature morphogenesis (GO:0060977) | 2.39744099 |
| 147 | positive regulation of glycogen biosynthetic process (GO:0045725) | 2.39227012 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 8.16427206 |
| 2 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 4.46973727 |
| 3 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 3.85436891 |
| 4 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 3.09688090 |
| 5 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.94564733 |
| 6 | CLOCK_20551151_ChIP-Seq_293T_Human | 2.85184555 |
| 7 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 2.55772941 |
| 8 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 2.55103469 |
| 9 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 2.50378280 |
| 10 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.49448038 |
| 11 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 2.33738769 |
| 12 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 2.11025112 |
| 13 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.90878588 |
| 14 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.88884383 |
| 15 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.88329153 |
| 16 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.88020703 |
| 17 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.83354253 |
| 18 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.81858321 |
| 19 | CJUN_26792858_Chip-Seq_BT549_Human | 1.79989703 |
| 20 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.78220136 |
| 21 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.76404729 |
| 22 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.74058323 |
| 23 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.74003135 |
| 24 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.73678024 |
| 25 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.71740778 |
| 26 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.71598402 |
| 27 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.69130265 |
| 28 | * RACK7_27058665_Chip-Seq_MCF-7_Human | 1.65571838 |
| 29 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.65025981 |
| 30 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.63083048 |
| 31 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.61145295 |
| 32 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.60671783 |
| 33 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.60671783 |
| 34 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.59718653 |
| 35 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.53517910 |
| 36 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.53517910 |
| 37 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.52819974 |
| 38 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.52207521 |
| 39 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.46941820 |
| 40 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.43104452 |
| 41 | ATF3_27146783_Chip-Seq_COLON_Human | 1.42755746 |
| 42 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.40972643 |
| 43 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.39524537 |
| 44 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.39351225 |
| 45 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.36704669 |
| 46 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.36206576 |
| 47 | * TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.35266423 |
| 48 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.34632582 |
| 49 | * NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.34584144 |
| 50 | * LXR_22292898_ChIP-Seq_THP-1_Human | 1.34358162 |
| 51 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.33371021 |
| 52 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.32938867 |
| 53 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.32802912 |
| 54 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.32378423 |
| 55 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.32354368 |
| 56 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.32277058 |
| 57 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.31520284 |
| 58 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.31194036 |
| 59 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.31015745 |
| 60 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.30069880 |
| 61 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.29489506 |
| 62 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.26800048 |
| 63 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.26028131 |
| 64 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.25943930 |
| 65 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.25876063 |
| 66 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.25352466 |
| 67 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.24220698 |
| 68 | * SOX2_20726797_ChIP-Seq_SW620_Human | 1.24046296 |
| 69 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.23847372 |
| 70 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.22757647 |
| 71 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.22378486 |
| 72 | * GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.21767095 |
| 73 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.21493315 |
| 74 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.20114199 |
| 75 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.19825402 |
| 76 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.19608167 |
| 77 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.19025021 |
| 78 | P68_20966046_ChIP-Seq_HELA_Human | 1.18336543 |
| 79 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.16450189 |
| 80 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.16362502 |
| 81 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 1.15842722 |
| 82 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.15732991 |
| 83 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.15479929 |
| 84 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.15263841 |
| 85 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.14846743 |
| 86 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.13488095 |
| 87 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.13458449 |
| 88 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.11874098 |
| 89 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.11791025 |
| 90 | KLF5_25053715_ChIP-Seq_YYC3_Human | 1.11594931 |
| 91 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.09882863 |
| 92 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.09228385 |
| 93 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.09137732 |
| 94 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.08578908 |
| 95 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.08385760 |
| 96 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.07455307 |
| 97 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.07419635 |
| 98 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.07016269 |
| 99 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.06571258 |
| 100 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.05876998 |
| 101 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.05845437 |
| 102 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.04418905 |
| 103 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.04388865 |
| 104 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.04085343 |
| 105 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.03878734 |
| 106 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.02976201 |
| 107 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.02818283 |
| 108 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.02521455 |
| 109 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.02250818 |
| 110 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.02250818 |
| 111 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.01821586 |
| 112 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.01588624 |
| 113 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.01044555 |
| 114 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.99073377 |
| 115 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.99073377 |
| 116 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.98888894 |
| 117 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.98142959 |
| 118 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.97204975 |
| 119 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.96784327 |
| 120 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 0.96266037 |
| 121 | TP53_16413492_ChIP-PET_HCT116_Human | 0.96252303 |
| 122 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.95534856 |
| 123 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.95467532 |
| 124 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.95467532 |
| 125 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.95467532 |
| 126 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.95348423 |
| 127 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.94491821 |
| 128 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.94167877 |
| 129 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.93703162 |
| 130 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.93589452 |
| 131 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.93576444 |
| 132 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.92184614 |
| 133 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.91098360 |
| 134 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.90988032 |
| 135 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.90161147 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008438_abnormal_cutaneous_collagen | 5.61812984 |
| 2 | MP0005275_abnormal_skin_tensile | 4.73345243 |
| 3 | MP0003705_abnormal_hypodermis_morpholog | 4.39140227 |
| 4 | MP0004272_abnormal_basement_membrane | 3.61789978 |
| 5 | MP0005503_abnormal_tendon_morphology | 2.95967862 |
| 6 | MP0003279_aneurysm | 2.63688345 |
| 7 | MP0003566_abnormal_cell_adhesion | 2.56567147 |
| 8 | MP0001958_emphysema | 2.41425221 |
| 9 | MP0005623_abnormal_meninges_morphology | 2.35372632 |
| 10 | MP0002060_abnormal_skin_morphology | 2.29244872 |
| 11 | MP0000751_myopathy | 2.21557371 |
| 12 | MP0004858_abnormal_nervous_system | 2.19592721 |
| 13 | MP0009384_cardiac_valve_regurgitation | 2.16446912 |
| 14 | MP0010234_abnormal_vibrissa_follicle | 2.07919356 |
| 15 | MP0002796_impaired_skin_barrier | 1.91806820 |
| 16 | MP0010030_abnormal_orbit_morphology | 1.83349428 |
| 17 | MP0002254_reproductive_system_inflammat | 1.67318617 |
| 18 | MP0000733_abnormal_muscle_development | 1.65717237 |
| 19 | MP0005257_abnormal_intraocular_pressure | 1.64488433 |
| 20 | MP0002877_abnormal_melanocyte_morpholog | 1.61346811 |
| 21 | MP0000750_abnormal_muscle_regeneration | 1.60648821 |
| 22 | MP0003941_abnormal_skin_development | 1.59286268 |
| 23 | MP0010368_abnormal_lymphatic_system | 1.57387185 |
| 24 | MP0006054_spinal_hemorrhage | 1.57182689 |
| 25 | MP0000767_abnormal_smooth_muscle | 1.52859369 |
| 26 | MP0005409_darkened_coat_color | 1.52297651 |
| 27 | MP0005023_abnormal_wound_healing | 1.50779393 |
| 28 | MP0005508_abnormal_skeleton_morphology | 1.49026465 |
| 29 | MP0004084_abnormal_cardiac_muscle | 1.48024704 |
| 30 | MP0003091_abnormal_cell_migration | 1.47617552 |
| 31 | MP0003045_fibrosis | 1.47178597 |
| 32 | MP0001542_abnormal_bone_strength | 1.43553518 |
| 33 | MP0000762_abnormal_tongue_morphology | 1.42399197 |
| 34 | MP0003385_abnormal_body_wall | 1.38136671 |
| 35 | MP0005058_abnormal_lysosome_morphology | 1.37771413 |
| 36 | MP0000749_muscle_degeneration | 1.34316447 |
| 37 | MP0005171_absent_coat_pigmentation | 1.34220366 |
| 38 | MP0002108_abnormal_muscle_morphology | 1.33938403 |
| 39 | MP0004185_abnormal_adipocyte_glucose | 1.32933667 |
| 40 | MP0001879_abnormal_lymphatic_vessel | 1.32096957 |
| 41 | MP0004087_abnormal_muscle_fiber | 1.30582154 |
| 42 | MP0010352_gastrointestinal_tract_polyps | 1.29951176 |
| 43 | MP0006138_congestive_heart_failure | 1.28336075 |
| 44 | MP0005670_abnormal_white_adipose | 1.27751691 |
| 45 | MP0002837_dystrophic_cardiac_calcinosis | 1.26551613 |
| 46 | MP0002896_abnormal_bone_mineralization | 1.26147379 |
| 47 | MP0002295_abnormal_pulmonary_circulatio | 1.26101597 |
| 48 | MP0005666_abnormal_adipose_tissue | 1.23712971 |
| 49 | MP0001849_ear_inflammation | 1.22583909 |
| 50 | MP0000579_abnormal_nail_morphology | 1.22445847 |
| 51 | MP0000534_abnormal_ureter_morphology | 1.20089806 |
| 52 | MP0005375_adipose_tissue_phenotype | 1.19252583 |
| 53 | MP0005076_abnormal_cell_differentiation | 1.19216630 |
| 54 | MP0001243_abnormal_dermal_layer | 1.18393774 |
| 55 | MP0005501_abnormal_skin_physiology | 1.17772166 |
| 56 | MP0000467_abnormal_esophagus_morphology | 1.17641781 |
| 57 | MP0000462_abnormal_digestive_system | 1.17616049 |
| 58 | MP0003453_abnormal_keratinocyte_physiol | 1.16394476 |
| 59 | MP0009250_abnormal_appendicular_skeleto | 1.16171205 |
| 60 | MP0001348_abnormal_lacrimal_gland | 1.15299375 |
| 61 | MP0000003_abnormal_adipose_tissue | 1.13919790 |
| 62 | MP0004233_abnormal_muscle_weight | 1.13048068 |
| 63 | MP0010630_abnormal_cardiac_muscle | 1.11397264 |
| 64 | MP0005330_cardiomyopathy | 1.10813891 |
| 65 | MP0000537_abnormal_urethra_morphology | 1.09636316 |
| 66 | MP0000013_abnormal_adipose_tissue | 1.05934986 |
| 67 | MP0003942_abnormal_urinary_system | 1.05411984 |
| 68 | MP0010678_abnormal_skin_adnexa | 1.03512724 |
| 69 | MP0008775_abnormal_heart_ventricle | 1.03072816 |
| 70 | MP0010771_integument_phenotype | 1.02890595 |
| 71 | MP0002249_abnormal_larynx_morphology | 1.01754837 |
| 72 | MP0002282_abnormal_trachea_morphology | 1.01442683 |
| 73 | MP0009840_abnormal_foam_cell | 1.01239109 |
| 74 | MP0000678_abnormal_parathyroid_gland | 1.00670342 |
| 75 | MP0005451_abnormal_body_composition | 1.00504383 |
| 76 | MP0003115_abnormal_respiratory_system | 0.99933569 |
| 77 | MP0005595_abnormal_vascular_smooth | 0.99765248 |
| 78 | MP0000759_abnormal_skeletal_muscle | 0.97278024 |
| 79 | MP0000383_abnormal_hair_follicle | 0.97062568 |
| 80 | MP0002089_abnormal_postnatal_growth/wei | 0.96251718 |
| 81 | MP0003950_abnormal_plasma_membrane | 0.95321090 |
| 82 | MP0002932_abnormal_joint_morphology | 0.95066219 |
| 83 | MP0002234_abnormal_pharynx_morphology | 0.94790169 |
| 84 | MP0000516_abnormal_urinary_system | 0.94681296 |
| 85 | MP0005367_renal/urinary_system_phenotyp | 0.94681296 |
| 86 | MP0000163_abnormal_cartilage_morphology | 0.92795623 |
| 87 | MP0002128_abnormal_blood_circulation | 0.92559385 |
| 88 | MP0004130_abnormal_muscle_cell | 0.92359965 |
| 89 | MP0002168_other_aberrant_phenotype | 0.92299709 |
| 90 | MP0003283_abnormal_digestive_organ | 0.92221180 |
| 91 | MP0000428_abnormal_craniofacial_morphol | 0.91968318 |
| 92 | MP0001544_abnormal_cardiovascular_syste | 0.90707043 |
| 93 | MP0005385_cardiovascular_system_phenoty | 0.90707043 |
| 94 | MP0001299_abnormal_eye_distance/ | 0.89615262 |
| 95 | MP0004264_abnormal_extraembryonic_tissu | 0.89058207 |
| 96 | MP0002972_abnormal_cardiac_muscle | 0.88721617 |
| 97 | MP0001614_abnormal_blood_vessel | 0.88302468 |
| 98 | MP0009053_abnormal_anal_canal | 0.88242498 |
| 99 | MP0001216_abnormal_epidermal_layer | 0.87605079 |
| 100 | MP0005620_abnormal_muscle_contractility | 0.86296324 |
| 101 | MP0002925_abnormal_cardiovascular_devel | 0.85466386 |
| 102 | MP0000566_synostosis | 0.85220838 |
| 103 | MP0000377_abnormal_hair_follicle | 0.84734262 |
| 104 | MP0002115_abnormal_skeleton_extremities | 0.84319537 |
| 105 | MP0004036_abnormal_muscle_relaxation | 0.83894049 |
| 106 | MP0002098_abnormal_vibrissa_morphology | 0.83832464 |
| 107 | MP0009780_abnormal_chondrocyte_physiolo | 0.83719362 |
| 108 | MP0002116_abnormal_craniofacial_bone | 0.82318373 |
| 109 | MP0005369_muscle_phenotype | 0.82194812 |
| 110 | MP0003755_abnormal_palate_morphology | 0.81452080 |
| 111 | MP0002106_abnormal_muscle_physiology | 0.80584522 |
| 112 | MP0009278_abnormal_bone_marrow | 0.79026035 |
| 113 | MP0003935_abnormal_craniofacial_develop | 0.78859215 |
| 114 | MP0008260_abnormal_autophagy | 0.77898605 |
| 115 | MP0000432_abnormal_head_morphology | 0.75866321 |
| 116 | MP0002113_abnormal_skeleton_development | 0.75710435 |
| 117 | MP0000049_abnormal_middle_ear | 0.75547794 |
| 118 | MP0005197_abnormal_uvea_morphology | 0.74773048 |
| 119 | MP0000538_abnormal_urinary_bladder | 0.74200162 |
| 120 | MP0000747_muscle_weakness | 0.73361864 |
| 121 | MP0003828_pulmonary_edema | 0.72946010 |
| 122 | MP0002111_abnormal_tail_morphology | 0.72318200 |
| 123 | MP0005390_skeleton_phenotype | 0.71745967 |
| 124 | MP0000858_altered_metastatic_potential | 0.70737722 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Protrusio acetabuli (HP:0003179) | 5.94158159 |
| 2 | Premature rupture of membranes (HP:0001788) | 5.78563611 |
| 3 | Atrophic scars (HP:0001075) | 4.90251061 |
| 4 | Ankle contracture (HP:0006466) | 4.46450765 |
| 5 | Increased connective tissue (HP:0009025) | 4.30028127 |
| 6 | Broad metatarsal (HP:0001783) | 4.28673002 |
| 7 | Shallow orbits (HP:0000586) | 4.19343833 |
| 8 | Type 1 muscle fiber predominance (HP:0003803) | 3.96772570 |
| 9 | Fragile skin (HP:0001030) | 3.89530965 |
| 10 | Cerebral aneurysm (HP:0004944) | 3.76490475 |
| 11 | Aortic dissection (HP:0002647) | 3.75428852 |
| 12 | Right ventricular cardiomyopathy (HP:0011663) | 3.65943669 |
| 13 | Spinal rigidity (HP:0003306) | 3.29946767 |
| 14 | Follicular hyperkeratosis (HP:0007502) | 3.23179712 |
| 15 | Neonatal short-limb short stature (HP:0008921) | 3.20880361 |
| 16 | Bladder diverticulum (HP:0000015) | 3.15891115 |
| 17 | Soft skin (HP:0000977) | 3.13019253 |
| 18 | Cervical subluxation (HP:0003308) | 3.06844335 |
| 19 | Aortic aneurysm (HP:0004942) | 3.03356489 |
| 20 | Muscle fiber splitting (HP:0003555) | 3.00864228 |
| 21 | Peritonitis (HP:0002586) | 2.95934019 |
| 22 | Increased variability in muscle fiber diameter (HP:0003557) | 2.95257032 |
| 23 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.94817802 |
| 24 | Milia (HP:0001056) | 2.93904374 |
| 25 | Mitral valve prolapse (HP:0001634) | 2.78112946 |
| 26 | Dilatation of the ascending aorta (HP:0005111) | 2.72860614 |
| 27 | Broad face (HP:0000283) | 2.70876504 |
| 28 | Difficulty climbing stairs (HP:0003551) | 2.70068056 |
| 29 | J-shaped sella turcica (HP:0002680) | 2.64643540 |
| 30 | Hyperacusis (HP:0010780) | 2.62864141 |
| 31 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.61784021 |
| 32 | Blue sclerae (HP:0000592) | 2.57250504 |
| 33 | Hyporeflexia of lower limbs (HP:0002600) | 2.55526605 |
| 34 | Wormian bones (HP:0002645) | 2.54392039 |
| 35 | Abnormality of dentin (HP:0010299) | 2.51074872 |
| 36 | Round ear (HP:0100830) | 2.45304565 |
| 37 | Achilles tendon contracture (HP:0001771) | 2.44677069 |
| 38 | Obstructive sleep apnea (HP:0002870) | 2.41733539 |
| 39 | Scapular winging (HP:0003691) | 2.38695552 |
| 40 | Hand muscle atrophy (HP:0009130) | 2.38257445 |
| 41 | Aneurysm (HP:0002617) | 2.31279622 |
| 42 | Joint stiffness (HP:0001387) | 2.29606091 |
| 43 | Wrist flexion contracture (HP:0001239) | 2.29457974 |
| 44 | Alopecia of scalp (HP:0002293) | 2.27582229 |
| 45 | Ventricular tachycardia (HP:0004756) | 2.25799474 |
| 46 | Aortic regurgitation (HP:0001659) | 2.24502230 |
| 47 | Difficulty running (HP:0009046) | 2.24213423 |
| 48 | Biconcave vertebral bodies (HP:0004586) | 2.23630051 |
| 49 | Genu recurvatum (HP:0002816) | 2.23392567 |
| 50 | Coronal craniosynostosis (HP:0004440) | 2.22717189 |
| 51 | Onycholysis (HP:0001806) | 2.21211791 |
| 52 | Stridor (HP:0010307) | 2.20586146 |
| 53 | Hyperextensible skin (HP:0000974) | 2.19972136 |
| 54 | Slender build (HP:0001533) | 2.18797480 |
| 55 | Vertebral compression fractures (HP:0002953) | 2.14988278 |
| 56 | Abnormality of the Achilles tendon (HP:0005109) | 2.14468765 |
| 57 | Overgrowth (HP:0001548) | 2.13182304 |
| 58 | Short nail (HP:0001799) | 2.12159033 |
| 59 | Elbow flexion contracture (HP:0002987) | 2.10089521 |
| 60 | Disproportionate tall stature (HP:0001519) | 2.06153652 |
| 61 | Vascular tortuosity (HP:0004948) | 2.02811836 |
| 62 | Osteolytic defects of the hand bones (HP:0009699) | 2.01284372 |
| 63 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.01284372 |
| 64 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.01079812 |
| 65 | Hypoplastic ischia (HP:0003175) | 2.00812509 |
| 66 | Ulnar bowing (HP:0003031) | 2.00375858 |
| 67 | Distal lower limb muscle weakness (HP:0009053) | 2.00267034 |
| 68 | Distal upper limb amyotrophy (HP:0007149) | 2.00196881 |
| 69 | Upper limb amyotrophy (HP:0009129) | 2.00196881 |
| 70 | Long toe (HP:0010511) | 1.99433586 |
| 71 | Lower limb amyotrophy (HP:0007210) | 1.99348535 |
| 72 | Flat acetabular roof (HP:0003180) | 1.99240247 |
| 73 | Hip contracture (HP:0003273) | 1.99239865 |
| 74 | Lymphangioma (HP:0100764) | 1.98282117 |
| 75 | Bronchomalacia (HP:0002780) | 1.96338348 |
| 76 | Advanced eruption of teeth (HP:0006288) | 1.95652204 |
| 77 | Thin bony cortex (HP:0002753) | 1.94161910 |
| 78 | Knee flexion contracture (HP:0006380) | 1.93960810 |
| 79 | Wide anterior fontanel (HP:0000260) | 1.93849768 |
| 80 | Deviation of the hallux (HP:0010051) | 1.91582112 |
| 81 | Radial bowing (HP:0002986) | 1.90797901 |
| 82 | Abnormality of the acetabulum (HP:0003170) | 1.90061440 |
| 83 | Turricephaly (HP:0000262) | 1.89758524 |
| 84 | Abnormal delivery (HP:0001787) | 1.89157298 |
| 85 | Ectopia lentis (HP:0001083) | 1.89074383 |
| 86 | Abnormality of the calf musculature (HP:0001430) | 1.87542019 |
| 87 | Thin ribs (HP:0000883) | 1.87509576 |
| 88 | Abnormality of the umbilical cord (HP:0010881) | 1.87424112 |
| 89 | Bowed forearm bones (HP:0003956) | 1.87415733 |
| 90 | Bowing of the arm (HP:0006488) | 1.87415733 |
| 91 | Bowel diverticulosis (HP:0005222) | 1.87146240 |
| 92 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.85908691 |
| 93 | Natal tooth (HP:0000695) | 1.85826547 |
| 94 | Joint laxity (HP:0001388) | 1.85268549 |
| 95 | Hypoplasia of the iris (HP:0007676) | 1.85173976 |
| 96 | Camptodactyly of toe (HP:0001836) | 1.84511357 |
| 97 | Nuclear cataract (HP:0100018) | 1.83637926 |
| 98 | Distal lower limb amyotrophy (HP:0008944) | 1.83062737 |
| 99 | Spondylolisthesis (HP:0003302) | 1.82528103 |
| 100 | Venous abnormality (HP:0002624) | 1.82271355 |
| 101 | Short hallux (HP:0010109) | 1.81976805 |
| 102 | Hypoventilation (HP:0002791) | 1.81923404 |
| 103 | Mesomelia (HP:0003027) | 1.81859619 |
| 104 | Congenital glaucoma (HP:0001087) | 1.81805582 |
| 105 | Tibial bowing (HP:0002982) | 1.81402049 |
| 106 | Coxa vara (HP:0002812) | 1.80572227 |
| 107 | Acanthosis nigricans (HP:0000956) | 1.79497628 |
| 108 | Sudden death (HP:0001699) | 1.79206156 |
| 109 | Arterial tortuosity (HP:0005116) | 1.78109139 |
| 110 | Hallux valgus (HP:0001822) | 1.75779514 |
| 111 | Aortic valve stenosis (HP:0001650) | 1.74754235 |
| 112 | Short 4th metacarpal (HP:0010044) | 1.74662091 |
| 113 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.74662091 |
| 114 | Pterygium (HP:0001059) | 1.74386942 |
| 115 | Mitral regurgitation (HP:0001653) | 1.73306932 |
| 116 | Abnormality of the ischium (HP:0003174) | 1.72747692 |
| 117 | Trismus (HP:0000211) | 1.71772956 |
| 118 | Premature skin wrinkling (HP:0100678) | 1.71201663 |
| 119 | Protruding ear (HP:0000411) | 1.70647888 |
| 120 | Infantile muscular hypotonia (HP:0008947) | 1.70019625 |
| 121 | Lipoatrophy (HP:0100578) | 1.69367743 |
| 122 | Long palpebral fissure (HP:0000637) | 1.69007810 |
| 123 | Generalized amyotrophy (HP:0003700) | 1.68950553 |
| 124 | Spinal cord compression (HP:0002176) | 1.67705091 |
| 125 | Hypotrichosis (HP:0001006) | 1.67451231 |
| 126 | Abnormality of the calcaneus (HP:0008364) | 1.67091288 |
| 127 | Venous insufficiency (HP:0005293) | 1.66965139 |
| 128 | Renal duplication (HP:0000075) | 1.66707827 |
| 129 | Tarsal synostosis (HP:0008368) | 1.66014834 |
| 130 | Limited hip movement (HP:0008800) | 1.65833860 |
| 131 | Pili torti (HP:0003777) | 1.65728764 |
| 132 | Deformed sella turcica (HP:0002681) | 1.62152739 |
| 133 | Abnormality of carpal bone ossification (HP:0006257) | 1.59945303 |
| 134 | Ulnar deviation of the wrist (HP:0003049) | 1.59878338 |
| 135 | Inguinal hernia (HP:0000023) | 1.59542217 |
| 136 | Abnormal ossification of hand bones (HP:0005921) | 1.58873356 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIB3 | 4.47097882 |
| 2 | TTN | 4.23407228 |
| 3 | LATS1 | 3.23843661 |
| 4 | DDR2 | 3.03185160 |
| 5 | PKN2 | 2.77902100 |
| 6 | ERN1 | 2.75209799 |
| 7 | SIK1 | 2.69931321 |
| 8 | EPHA2 | 2.60853174 |
| 9 | PDGFRA | 2.55916293 |
| 10 | EPHB2 | 2.42138016 |
| 11 | IRAK3 | 2.36300862 |
| 12 | RIPK1 | 2.28963360 |
| 13 | PTK6 | 2.19696576 |
| 14 | EPHB1 | 2.18633815 |
| 15 | LATS2 | 2.17605753 |
| 16 | FER | 2.03931276 |
| 17 | TESK1 | 1.91342990 |
| 18 | SMG1 | 1.88553289 |
| 19 | DMPK | 1.72753089 |
| 20 | EEF2K | 1.66259268 |
| 21 | BMX | 1.60164601 |
| 22 | PTK2 | 1.56815590 |
| 23 | EPHA3 | 1.54699312 |
| 24 | TGFBR2 | 1.54226698 |
| 25 | LRRK2 | 1.51986554 |
| 26 | TIE1 | 1.50802314 |
| 27 | MAP3K3 | 1.49379416 |
| 28 | PAK2 | 1.48987257 |
| 29 | PAK4 | 1.45489368 |
| 30 | MET | 1.42624025 |
| 31 | FGFR4 | 1.42220633 |
| 32 | CAMK1D | 1.36534307 |
| 33 | MST1R | 1.24795754 |
| 34 | MAPKAPK3 | 1.24396062 |
| 35 | STK38L | 1.22258310 |
| 36 | NME2 | 1.19354084 |
| 37 | MUSK | 1.16283693 |
| 38 | MYLK | 1.11992527 |
| 39 | TRPM7 | 1.10882292 |
| 40 | FGFR1 | 1.07228713 |
| 41 | MAP3K7 | 1.06576905 |
| 42 | MTOR | 1.06021350 |
| 43 | LIMK1 | 1.05315047 |
| 44 | PDGFRB | 1.03414815 |
| 45 | MAP3K10 | 1.02335217 |
| 46 | CAMK1G | 1.01282355 |
| 47 | RPS6KB2 | 1.00605926 |
| 48 | MAP3K6 | 0.99526467 |
| 49 | PAK3 | 0.98611049 |
| 50 | FLT3 | 0.98143142 |
| 51 | ROCK1 | 0.97121150 |
| 52 | MAP2K1 | 0.94892837 |
| 53 | LMTK2 | 0.92928055 |
| 54 | STK3 | 0.92584273 |
| 55 | ILK | 0.92068998 |
| 56 | RPS6KA4 | 0.89872532 |
| 57 | PTK2B | 0.88870496 |
| 58 | PIK3CA | 0.86344396 |
| 59 | MAP2K3 | 0.86318964 |
| 60 | MAPK15 | 0.82864486 |
| 61 | ERBB4 | 0.82516782 |
| 62 | PRKD1 | 0.80986931 |
| 63 | ICK | 0.79513862 |
| 64 | MAP2K2 | 0.77182567 |
| 65 | STK10 | 0.75732587 |
| 66 | TYRO3 | 0.75575734 |
| 67 | RET | 0.75160189 |
| 68 | OBSCN | 0.73354813 |
| 69 | BCKDK | 0.71858463 |
| 70 | FGFR2 | 0.69902660 |
| 71 | MOS | 0.65483590 |
| 72 | PIK3CG | 0.65129230 |
| 73 | ARAF | 0.63886053 |
| 74 | RPS6KC1 | 0.63578909 |
| 75 | RPS6KL1 | 0.63578909 |
| 76 | ERBB2 | 0.63543111 |
| 77 | KDR | 0.63185866 |
| 78 | ROCK2 | 0.60793732 |
| 79 | CDK12 | 0.60425085 |
| 80 | PHKG1 | 0.60289898 |
| 81 | PHKG2 | 0.60289898 |
| 82 | TGFBR1 | 0.59266332 |
| 83 | PRPF4B | 0.58707343 |
| 84 | FGFR3 | 0.58151205 |
| 85 | TAOK1 | 0.53904099 |
| 86 | PIM2 | 0.53641734 |
| 87 | PRKAA2 | 0.50367711 |
| 88 | TAOK2 | 0.50362619 |
| 89 | DYRK1B | 0.50359719 |
| 90 | CDC42BPA | 0.49872184 |
| 91 | CHUK | 0.48750608 |
| 92 | CDK8 | 0.48454979 |
| 93 | TESK2 | 0.47298352 |
| 94 | PDPK1 | 0.47257053 |
| 95 | ABL2 | 0.47066868 |
| 96 | CDK7 | 0.46511501 |
| 97 | CDK6 | 0.46247119 |
| 98 | WNK4 | 0.45904294 |
| 99 | NEK9 | 0.44815636 |
| 100 | PRKD2 | 0.43619012 |
| 101 | IRAK2 | 0.43074434 |
| 102 | INSR | 0.42198985 |
| 103 | PDK3 | 0.42131874 |
| 104 | PDK4 | 0.42131874 |
| 105 | GSK3A | 0.41216954 |
| 106 | SCYL2 | 0.41163516 |
| 107 | PRKG2 | 0.40983292 |
| 108 | CAMK2G | 0.40344466 |
| 109 | MARK2 | 0.39264742 |
| 110 | AKT3 | 0.39165111 |
| 111 | PDK2 | 0.38401810 |
| 112 | SRC | 0.35631824 |
| 113 | DAPK3 | 0.34740237 |
| 114 | AKT2 | 0.33642260 |
| 115 | JAK1 | 0.32918382 |
| 116 | NTRK1 | 0.31603425 |
| 117 | MAP3K8 | 0.29833302 |
| 118 | PRKCI | 0.29812281 |
| 119 | PRKD3 | 0.29130150 |
| 120 | RPS6KA2 | 0.28988165 |
| 121 | BRAF | 0.26506351 |
| 122 | WNK1 | 0.26419775 |
| 123 | TBK1 | 0.25923900 |
| 124 | MAPKAPK2 | 0.25325955 |
| 125 | RPS6KA6 | 0.25024442 |
| 126 | MAPK12 | 0.23748190 |
| 127 | STK38 | 0.22875050 |
| 128 | PAK1 | 0.22675736 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ECM-receptor interaction_Homo sapiens_hsa04512 | 4.08569509 |
| 2 | Protein digestion and absorption_Homo sapiens_hsa04974 | 2.95135889 |
| 3 | Focal adhesion_Homo sapiens_hsa04510 | 2.85988013 |
| 4 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.47424015 |
| 5 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.43061086 |
| 6 | Adherens junction_Homo sapiens_hsa04520 | 2.35283348 |
| 7 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 2.24426624 |
| 8 | Basal cell carcinoma_Homo sapiens_hsa05217 | 2.19844957 |
| 9 | Other glycan degradation_Homo sapiens_hsa00511 | 2.18671891 |
| 10 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 2.13290324 |
| 11 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 2.11724705 |
| 12 | Amoebiasis_Homo sapiens_hsa05146 | 2.04601324 |
| 13 | Small cell lung cancer_Homo sapiens_hsa05222 | 2.02385330 |
| 14 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.91517260 |
| 15 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.78139263 |
| 16 | Bladder cancer_Homo sapiens_hsa05219 | 1.73915146 |
| 17 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.69248832 |
| 18 | Tight junction_Homo sapiens_hsa04530 | 1.62654332 |
| 19 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.54093013 |
| 20 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.52742129 |
| 21 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.51337966 |
| 22 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.49312519 |
| 23 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.43189195 |
| 24 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.39009677 |
| 25 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.34278949 |
| 26 | Viral myocarditis_Homo sapiens_hsa05416 | 1.32196935 |
| 27 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.29563860 |
| 28 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.28843013 |
| 29 | Sulfur relay system_Homo sapiens_hsa04122 | 1.28245066 |
| 30 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.26210390 |
| 31 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.24681219 |
| 32 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.21970435 |
| 33 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.21803256 |
| 34 | Insulin resistance_Homo sapiens_hsa04931 | 1.14893990 |
| 35 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.13190294 |
| 36 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.12362147 |
| 37 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.09785699 |
| 38 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 1.08894059 |
| 39 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.07567360 |
| 40 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.06365419 |
| 41 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.03606202 |
| 42 | Pathways in cancer_Homo sapiens_hsa05200 | 1.03192844 |
| 43 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.03076091 |
| 44 | Prion diseases_Homo sapiens_hsa05020 | 1.02532132 |
| 45 | Melanoma_Homo sapiens_hsa05218 | 1.01823305 |
| 46 | Galactose metabolism_Homo sapiens_hsa00052 | 0.99997528 |
| 47 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.97144912 |
| 48 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.93399838 |
| 49 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.91868110 |
| 50 | Axon guidance_Homo sapiens_hsa04360 | 0.90959120 |
| 51 | Malaria_Homo sapiens_hsa05144 | 0.90864147 |
| 52 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.90622822 |
| 53 | Lysine degradation_Homo sapiens_hsa00310 | 0.90396211 |
| 54 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.90257600 |
| 55 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.88769204 |
| 56 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.88697364 |
| 57 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.88003592 |
| 58 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.87018386 |
| 59 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.84774255 |
| 60 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.84482941 |
| 61 | Platelet activation_Homo sapiens_hsa04611 | 0.83917592 |
| 62 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.83321681 |
| 63 | Lysosome_Homo sapiens_hsa04142 | 0.80954065 |
| 64 | Prostate cancer_Homo sapiens_hsa05215 | 0.80067544 |
| 65 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.79478292 |
| 66 | Endometrial cancer_Homo sapiens_hsa05213 | 0.79395689 |
| 67 | Melanogenesis_Homo sapiens_hsa04916 | 0.78607721 |
| 68 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.75914646 |
| 69 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.75819733 |
| 70 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.72828211 |
| 71 | Endocytosis_Homo sapiens_hsa04144 | 0.72327031 |
| 72 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.71427052 |
| 73 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.70934260 |
| 74 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.70931687 |
| 75 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.70681441 |
| 76 | Gap junction_Homo sapiens_hsa04540 | 0.69496268 |
| 77 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.67313562 |
| 78 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.66611391 |
| 79 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.66326311 |
| 80 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.66239579 |
| 81 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.65645879 |
| 82 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.64389045 |
| 83 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.61603813 |
| 84 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.61021147 |
| 85 | HTLV-I infection_Homo sapiens_hsa05166 | 0.60950928 |
| 86 | Glioma_Homo sapiens_hsa05214 | 0.60473795 |
| 87 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.59457955 |
| 88 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.58931811 |
| 89 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.58327538 |
| 90 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.57149672 |
| 91 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.56323448 |
| 92 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.56242346 |
| 93 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.55329023 |
| 94 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.55238406 |
| 95 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.53968360 |
| 96 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.53573847 |
| 97 | Hepatitis C_Homo sapiens_hsa05160 | 0.52125192 |
| 98 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.52069304 |
| 99 | Bile secretion_Homo sapiens_hsa04976 | 0.51102130 |
| 100 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.50354471 |
| 101 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.47939488 |
| 102 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.47089000 |
| 103 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.45896230 |
| 104 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.45621252 |
| 105 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.45603501 |
| 106 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.45413296 |
| 107 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.44667355 |
| 108 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.41287582 |
| 109 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.40675242 |
| 110 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.40423876 |
| 111 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.39954976 |
| 112 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.39780927 |
| 113 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.39021283 |
| 114 | Shigellosis_Homo sapiens_hsa05131 | 0.38950354 |
| 115 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.38791154 |
| 116 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.38586927 |
| 117 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.37800948 |
| 118 | Salmonella infection_Homo sapiens_hsa05132 | 0.37749242 |
| 119 | Thyroid cancer_Homo sapiens_hsa05216 | 0.37708068 |
| 120 | Colorectal cancer_Homo sapiens_hsa05210 | 0.37626910 |
| 121 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.37482652 |
| 122 | Apoptosis_Homo sapiens_hsa04210 | 0.37085658 |
| 123 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.36653462 |
| 124 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.35490287 |
| 125 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.35188101 |
| 126 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.35179597 |

