ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	microtubule severing (GO:0051013)	7.93379801
2	polyamine biosynthetic process (GO:0006596)	7.80229969
3	sperm motility (GO:0030317)	7.74384016
4	acrosome reaction (GO:0007340)	7.59510836
5	fusion of sperm to egg plasma membrane (GO:0007342)	7.24584609
6	angiotensin maturation (GO:0002003)	5.61109291
7	protein polyglutamylation (GO:0018095)	5.57369851
8	spermatid development (GO:0007286)	5.51637346
9	cellular biogenic amine biosynthetic process (GO:0042401)	5.49374050
10	response to pheromone (GO:0019236)	5.46262450
11	plasma membrane fusion (GO:0045026)	5.42842946
12	multicellular organism reproduction (GO:0032504)	5.22279721
13	amine biosynthetic process (GO:0009309)	5.14385834
14	microtubule depolymerization (GO:0007019)	5.11369914
15	positive regulation of endothelial cell differentiation (GO:0045603)	5.07910648
16	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	5.07023589
17	cell wall macromolecule catabolic process (GO:0016998)	5.02104699
18	thalamus development (GO:0021794)	5.00969246
19	reproduction (GO:0000003)	4.79651305
20	sperm-egg recognition (GO:0035036)	4.77805887
21	polyamine metabolic process (GO:0006595)	4.77640416
22	negative regulation of inclusion body assembly (GO:0090084)	4.76370033
23	sperm capacitation (GO:0048240)	4.76225095
24	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.60801056
25	regulation of inclusion body assembly (GO:0090083)	4.54888689
26	regulation of protein kinase A signaling (GO:0010738)	4.52543515
27	spermatid nucleus differentiation (GO:0007289)	4.49666360
28	adult feeding behavior (GO:0008343)	4.42462292
29	phosphatidylethanolamine metabolic process (GO:0046337)	4.32540652
30	cell wall macromolecule metabolic process (GO:0044036)	4.30320298
31	amine catabolic process (GO:0009310)	4.23104969
32	cellular biogenic amine catabolic process (GO:0042402)	4.23104969
33	protein targeting to Golgi (GO:0000042)	4.22148383
34	establishment of protein localization to Golgi (GO:0072600)	4.14125861
35	calcium ion-dependent exocytosis (GO:0017156)	4.07808269
36	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.07440699
37	negative regulation of platelet activation (GO:0010544)	4.04118804
38	DNA packaging (GO:0006323)	4.02116061
39	regulation of transcription involved in cell fate commitment (GO:0060850)	3.97885322
40	chromosome condensation (GO:0030261)	3.94490700
41	regulation of cilium movement (GO:0003352)	3.94016794
42	axonemal dynein complex assembly (GO:0070286)	3.91758178
43	cilium or flagellum-dependent cell motility (GO:0001539)	3.90593045
44	response to acidic pH (GO:0010447)	3.88832228
45	single strand break repair (GO:0000012)	3.88492803
46	cochlea development (GO:0090102)	3.84191022
47	cell-cell recognition (GO:0009988)	3.82963372
48	binding of sperm to zona pellucida (GO:0007339)	3.75268325
49	spermatogenesis (GO:0007283)	3.72991981
50	male gamete generation (GO:0048232)	3.71842931
51	regulation of glucokinase activity (GO:0033131)	3.67980498
52	regulation of hexokinase activity (GO:1903299)	3.67980498
53	low-density lipoprotein particle remodeling (GO:0034374)	3.67466694
54	cellular ketone body metabolic process (GO:0046950)	3.64758422
55	rRNA methylation (GO:0031167)	3.60293406
56	regulation of platelet activation (GO:0010543)	3.59714514
57	negative regulation of homotypic cell-cell adhesion (GO:0034111)	3.58953046
58	cAMP catabolic process (GO:0006198)	3.58705040
59	regulation of endothelial cell differentiation (GO:0045601)	3.57122602
60	regulation of actin nucleation (GO:0051125)	3.54736402
61	DNA integration (GO:0015074)	3.54368542
62	regulation of platelet aggregation (GO:0090330)	3.51752792
63	sexual reproduction (GO:0019953)	3.49481645
64	gamete generation (GO:0007276)	3.45894805
65	regulation of cholesterol esterification (GO:0010872)	3.36383750
66	regulation of microtubule-based movement (GO:0060632)	3.33904803
67	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.33847877
68	single fertilization (GO:0007338)	3.33337572
69	microtubule polymerization or depolymerization (GO:0031109)	3.30578996
70	RNA destabilization (GO:0050779)	3.29465058
71	organic cation transport (GO:0015695)	3.29423038
72	cGMP-mediated signaling (GO:0019934)	3.29417685
73	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.24736573
74	superoxide anion generation (GO:0042554)	3.21282115
75	midbrain development (GO:0030901)	3.19697170
76	ketone body metabolic process (GO:1902224)	3.17919627
77	cyclic nucleotide catabolic process (GO:0009214)	3.16971669
78	intra-Golgi vesicle-mediated transport (GO:0006891)	3.15201509
79	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	3.06205313
80	neurotransmitter-gated ion channel clustering (GO:0072578)	3.05428506
81	positive regulation of Rab GTPase activity (GO:0032851)	3.05253627
82	regulation of Rab GTPase activity (GO:0032313)	3.05253627
83	regulation of MHC class II biosynthetic process (GO:0045346)	3.00322578
84	chromatin silencing (GO:0006342)	2.96062861
85	primary amino compound metabolic process (GO:1901160)	2.95454442
86	germ cell development (GO:0007281)	2.94075409
87	nitric oxide mediated signal transduction (GO:0007263)	2.93235115
88	lung vasculature development (GO:0060426)	2.91956523
89	glycosphingolipid biosynthetic process (GO:0006688)	2.89486365
90	cardiolipin metabolic process (GO:0032048)	2.82997452
91	lipoxygenase pathway (GO:0019372)	2.80648453
92	rRNA modification (GO:0000154)	2.74638147
93	receptor recycling (GO:0001881)	2.73998168
94	transmission of nerve impulse (GO:0019226)	2.71680763
95	cGMP metabolic process (GO:0046068)	2.71578099
96	response to dietary excess (GO:0002021)	2.70430838
97	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.68359779
98	arginine metabolic process (GO:0006525)	2.66684192
99	multicellular organismal reproductive process (GO:0048609)	2.66281072
100	phospholipid efflux (GO:0033700)	2.62439469

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.70157815
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.11464471
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.45042153
4	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.30000472
5	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30000472
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.28050808
7	DROSHA_22980978_ChIP-Seq_HELA_Human	2.22262179
8	TAF15_26573619_Chip-Seq_HEK293_Human	1.99050906
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.95720807
10	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.93686955
11	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.80466083
12	FUS_26573619_Chip-Seq_HEK293_Human	1.71558925
13	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.60002142
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.58350871
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.58017625
16	P300_19829295_ChIP-Seq_ESCs_Human	1.57442850
17	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.53475196
18	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.52366015
19	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.51942524
20	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.51854897
21	AR_25329375_ChIP-Seq_VCAP_Human	1.47681270
22	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47355149
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43868851
24	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.43578842
25	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.42167127
26	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41456267
27	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.40763693
28	AR_21572438_ChIP-Seq_LNCaP_Human	1.38579988
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36229582
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.35235755
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.34531348
32	OCT4_20526341_ChIP-Seq_ESCs_Human	1.34423478
33	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.33709045
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32265706
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.32265706
36	NANOG_20526341_ChIP-Seq_ESCs_Human	1.31441663
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31196366
38	GBX2_23144817_ChIP-Seq_PC3_Human	1.31153818
39	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.30406925
40	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.29910936
41	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.26912942
42	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.26822305
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.26489383
44	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.25208380
45	RAC3_21632823_ChIP-Seq_H3396_Human	1.23823605
46	ERA_21632823_ChIP-Seq_H3396_Human	1.23432824
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.23107653
48	ERG_20517297_ChIP-Seq_VCAP_Human	1.22836614
49	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.22386313
50	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.22115042
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21663808
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20457950
53	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.19917048
54	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.19851414
55	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17982529
56	TP53_18474530_ChIP-ChIP_U2OS_Human	1.17755320
57	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.17653529
58	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.17487558
59	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.17375569
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16882763
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16882763
62	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.16249242
63	ZNF274_21170338_ChIP-Seq_K562_Hela	1.15829098
64	E2F1_20622854_ChIP-Seq_HELA_Human	1.15724475
65	HTT_18923047_ChIP-ChIP_STHdh_Human	1.14754712
66	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.12721036
67	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.12572465
68	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.12240370
69	CDX2_22108803_ChIP-Seq_LS180_Human	1.11891277
70	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.11700184
71	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.11684266
72	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.11576867
73	STAT3_23295773_ChIP-Seq_U87_Human	1.11277256
74	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.11269788
75	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.10849215
76	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.10499642
77	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.10387246
78	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.09388736
79	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.08168237
80	BCL6_27268052_Chip-Seq_Bcells_Human	1.08060811
81	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.07773911
82	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07550839
83	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.07044574
84	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.06848980
85	KLF4_19829295_ChIP-Seq_ESCs_Human	1.06390642
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.06107786
87	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.06094503
88	PHF8_20622854_ChIP-Seq_HELA_Human	1.05605348
89	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05575627
90	P300_27268052_Chip-Seq_Bcells_Human	1.05506856
91	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.04865279
92	SMRT_27268052_Chip-Seq_Bcells_Human	1.03341338
93	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02095900
94	MYC_19829295_ChIP-Seq_ESCs_Human	1.01793200
95	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.00983780
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00896058
97	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.00417153
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00342478
99	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.99792846
100	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.99784674

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	6.81601440
2	MP0003011_delayed_dark_adaptation	2.96257190
3	MP0000569_abnormal_digit_pigmentation	2.92136474
4	MP0005670_abnormal_white_adipose	2.88800731
5	MP0003879_abnormal_hair_cell	2.78151002
6	MP0002138_abnormal_hepatobiliary_system	2.70148895
7	MP0005085_abnormal_gallbladder_physiolo	2.60885041
8	MP0003698_abnormal_male_reproductive	2.51190488
9	MP0005464_abnormal_platelet_physiology	2.46238942
10	MP0005367_renal/urinary_system_phenotyp	2.41563536
11	MP0000516_abnormal_urinary_system	2.41563536
12	MP0005248_abnormal_Harderian_gland	2.41503174
13	MP0005365_abnormal_bile_salt	2.41180876
14	MP0005646_abnormal_pituitary_gland	2.38502238
15	MP0005379_endocrine/exocrine_gland_phen	2.37203332
16	MP0008004_abnormal_stomach_pH	2.35293073
17	MP0002736_abnormal_nociception_after	2.34669302
18	MP0001968_abnormal_touch/_nociception	2.29782012
19	MP0005083_abnormal_biliary_tract	2.24989958
20	MP0001929_abnormal_gametogenesis	1.99301747
21	MP0002132_abnormal_respiratory_system	1.95895516
22	MP0002733_abnormal_thermal_nociception	1.81527358
23	MP0009840_abnormal_foam_cell	1.78449447
24	MP0005377_hearing/vestibular/ear_phenot	1.73673794
25	MP0003878_abnormal_ear_physiology	1.73673794
26	MP0002971_abnormal_brown_adipose	1.63103297
27	MP0001545_abnormal_hematopoietic_system	1.63004672
28	MP0005397_hematopoietic_system_phenotyp	1.63004672
29	MP0009764_decreased_sensitivity_to	1.62404907
30	MP0003252_abnormal_bile_duct	1.61471660
31	MP0005645_abnormal_hypothalamus_physiol	1.60281777
32	MP0003718_maternal_effect	1.57656058
33	MP0002234_abnormal_pharynx_morphology	1.55188160
34	MP0001348_abnormal_lacrimal_gland	1.53646311
35	MP0008569_lethality_at_weaning	1.53147222
36	MP0003172_abnormal_lysosome_physiology	1.50511242
37	MP0003724_increased_susceptibility_to	1.48236563
38	MP0003329_amyloid_beta_deposits	1.39546265
39	MP0004142_abnormal_muscle_tone	1.37587453
40	MP0005253_abnormal_eye_physiology	1.37564863
41	MP0001529_abnormal_vocalization	1.35308170
42	MP0000604_amyloidosis	1.33910775
43	MP0005167_abnormal_blood-brain_barrier	1.32890671
44	MP0000026_abnormal_inner_ear	1.32176675
45	MP0005257_abnormal_intraocular_pressure	1.30062690
46	MP0002161_abnormal_fertility/fecundity	1.26730836
47	MP0001486_abnormal_startle_reflex	1.25483466
48	MP0000015_abnormal_ear_pigmentation	1.24421914
49	MP0002909_abnormal_adrenal_gland	1.22207163
50	MP0004019_abnormal_vitamin_homeostasis	1.22199798
51	MP0002572_abnormal_emotion/affect_behav	1.19287701
52	MP0002229_neurodegeneration	1.19259533
53	MP0001963_abnormal_hearing_physiology	1.18216449
54	MP0003787_abnormal_imprinting	1.17662898
55	MP0008877_abnormal_DNA_methylation	1.17600787
56	MP0009115_abnormal_fat_cell	1.17183180
57	MP0002254_reproductive_system_inflammat	1.14593193
58	MP0002009_preneoplasia	1.13602297
59	MP0005623_abnormal_meninges_morphology	1.05511551
60	MP0005310_abnormal_salivary_gland	1.05162036
61	MP0003656_abnormal_erythrocyte_physiolo	1.02737592
62	MP0006082_CNS_inflammation	1.01992098
63	MP0003633_abnormal_nervous_system	0.98233053
64	MP0009745_abnormal_behavioral_response	0.97224880
65	MP0003690_abnormal_glial_cell	0.96829162
66	MP0002332_abnormal_exercise_endurance	0.96685966
67	MP0002090_abnormal_vision	0.96559439
68	MP0003137_abnormal_impulse_conducting	0.96399368
69	MP0008874_decreased_physiological_sensi	0.94690118
70	MP0001970_abnormal_pain_threshold	0.93719748
71	MP0004859_abnormal_synaptic_plasticity	0.92901875
72	MP0005551_abnormal_eye_electrophysiolog	0.92868281
73	MP0003941_abnormal_skin_development	0.91282558
74	MP0002735_abnormal_chemical_nociception	0.90434244
75	MP0002210_abnormal_sex_determination	0.90327793
76	MP0001145_abnormal_male_reproductive	0.89140436
77	MP0002064_seizures	0.88858577
78	MP0003959_abnormal_lean_body	0.87515738
79	MP0003303_peritoneal_inflammation	0.87168741
80	MP0000230_abnormal_systemic_arterial	0.86014917
81	MP0005084_abnormal_gallbladder_morpholo	0.84125113
82	MP0004036_abnormal_muscle_relaxation	0.84067206
83	MP0000653_abnormal_sex_gland	0.82920122
84	MP0002067_abnormal_sensory_capabilities	0.82044938
85	MP0000343_altered_response_to	0.82020944
86	MP0000465_gastrointestinal_hemorrhage	0.81164218
87	MP0004510_myositis	0.78725156
88	MP0002557_abnormal_social/conspecific_i	0.78617127
89	MP0000678_abnormal_parathyroid_gland	0.77078044
90	MP0002822_catalepsy	0.76923075
91	MP0001664_abnormal_digestion	0.76651526
92	MP0005174_abnormal_tail_pigmentation	0.74540117
93	MP0003646_muscle_fatigue	0.74118226
94	MP0003635_abnormal_synaptic_transmissio	0.73906502
95	MP0004742_abnormal_vestibular_system	0.73184425
96	MP0010329_abnormal_lipoprotein_level	0.71271209
97	MP0005584_abnormal_enzyme/coenzyme_acti	0.67165644
98	MP0002272_abnormal_nervous_system	0.66075483
99	MP0003631_nervous_system_phenotype	0.64419680
100	MP0000955_abnormal_spinal_cord	0.63722724

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	6.65793525
2	Abnormality of lateral ventricle (HP:0030047)	4.94593221
3	Upper limb muscle weakness (HP:0003484)	4.85957107
4	Peripheral hypomyelination (HP:0007182)	4.40237074
5	Failure to thrive in infancy (HP:0001531)	4.08184640
6	Hematochezia (HP:0002573)	4.00604247
7	Hyperkalemia (HP:0002153)	4.00246718
8	Attenuation of retinal blood vessels (HP:0007843)	3.82053931
9	Pendular nystagmus (HP:0012043)	3.78788765
10	Bony spicule pigmentary retinopathy (HP:0007737)	3.78369976
11	Conjugated hyperbilirubinemia (HP:0002908)	3.56891661
12	Petechiae (HP:0000967)	3.53487895
13	Abnormality of macular pigmentation (HP:0008002)	3.50276115
14	Late onset (HP:0003584)	3.47871908
15	Hypophosphatemic rickets (HP:0004912)	3.43916027
16	Type II lissencephaly (HP:0007260)	3.39646927
17	Prolonged bleeding time (HP:0003010)	3.27825856
18	Tubulointerstitial nephritis (HP:0001970)	3.22602547
19	Thyroid-stimulating hormone excess (HP:0002925)	3.16874764
20	Retinal atrophy (HP:0001105)	3.14962155
21	Agitation (HP:0000713)	3.05920328
22	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.00309851
23	Abnormal rod and cone electroretinograms (HP:0008323)	3.00140887
24	Vacuolated lymphocytes (HP:0001922)	2.99689655
25	Mesangial abnormality (HP:0001966)	2.95961660
26	Increased mean platelet volume (HP:0011877)	2.95134355
27	Abnormality of the corticospinal tract (HP:0002492)	2.79496088
28	Metaphyseal dysplasia (HP:0100255)	2.79321633
29	Hypoalphalipoproteinemia (HP:0003233)	2.77392711
30	Optic nerve hypoplasia (HP:0000609)	2.77114475
31	Myoglobinuria (HP:0002913)	2.73871786
32	Cerebral inclusion bodies (HP:0100314)	2.72709309
33	Enlarged epiphyses (HP:0010580)	2.70501645
34	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.68044780
35	Absent/shortened dynein arms (HP:0200106)	2.68044780
36	Gingival bleeding (HP:0000225)	2.68021602
37	Anterior segment dysgenesis (HP:0007700)	2.61196099
38	Abnormal platelet volume (HP:0011876)	2.57318770
39	Intrahepatic cholestasis (HP:0001406)	2.55914301
40	Neurofibrillary tangles (HP:0002185)	2.55151644
41	Ulnar claw (HP:0001178)	2.48466131
42	Abnormality of secondary sexual hair (HP:0009888)	2.47927790
43	Abnormality of the axillary hair (HP:0100134)	2.47927790
44	Pachygyria (HP:0001302)	2.45931137
45	Abnormality of potassium homeostasis (HP:0011042)	2.44738121
46	Abnormal respiratory motile cilium physiology (HP:0012261)	2.43400892
47	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.37737387
48	Abnormality of glycolipid metabolism (HP:0010969)	2.35090826
49	Abnormality of liposaccharide metabolism (HP:0010968)	2.35090826
50	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.35090826
51	Chronic hepatic failure (HP:0100626)	2.33629482
52	Cerebellar dysplasia (HP:0007033)	2.30136447
53	Menorrhagia (HP:0000132)	2.27721168
54	Retinal dysplasia (HP:0007973)	2.27030656
55	Amelogenesis imperfecta (HP:0000705)	2.25770708
56	Microglossia (HP:0000171)	2.23895025
57	Insidious onset (HP:0003587)	2.23025067
58	Termporal pattern (HP:0011008)	2.23025067
59	Increased density of long bones (HP:0006392)	2.22780238
60	Cone-rod dystrophy (HP:0000548)	2.18506698
61	Abnormal respiratory motile cilium morphology (HP:0005938)	2.15925929
62	Abnormal respiratory epithelium morphology (HP:0012253)	2.15925929
63	Renal dysplasia (HP:0000110)	2.10277291
64	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.09809712
65	Menstrual irregularities (HP:0000858)	2.09013827
66	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.07523605
67	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.07523605
68	Purpura (HP:0000979)	2.06663889
69	Spontaneous hematomas (HP:0007420)	2.02561123
70	Gonadal dysgenesis (HP:0000133)	2.02359205
71	Nephronophthisis (HP:0000090)	2.02027838
72	Vertebral clefting (HP:0008428)	2.01049018
73	Lissencephaly (HP:0001339)	2.00646100
74	Epistaxis (HP:0000421)	2.00613730
75	Abnormality of purine metabolism (HP:0004352)	1.99556660
76	Portal hypertension (HP:0001409)	1.99012870
77	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.98879954
78	Horizontal nystagmus (HP:0000666)	1.97727926
79	Generalized aminoaciduria (HP:0002909)	1.97217232
80	Concave nail (HP:0001598)	1.93372393
81	Hypoplasia of the uterus (HP:0000013)	1.92555828
82	Febrile seizures (HP:0002373)	1.92135263
83	Difficulty walking (HP:0002355)	1.89281682
84	Short tibia (HP:0005736)	1.89189535
85	Pancreatic fibrosis (HP:0100732)	1.88686639
86	Abnormal sex determination (HP:0012244)	1.88288696
87	Sex reversal (HP:0012245)	1.88288696
88	Peripheral demyelination (HP:0011096)	1.86604986
89	Hypoplastic ischia (HP:0003175)	1.86240494
90	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.86103240
91	Infertility (HP:0000789)	1.85230036
92	Aplasia/hypoplasia of the uterus (HP:0008684)	1.84681020
93	Impaired platelet aggregation (HP:0003540)	1.83745901
94	Abnormal platelet function (HP:0011869)	1.83745901
95	Abnormal glucose tolerance (HP:0001952)	1.83380331
96	Abnormality of the renal medulla (HP:0100957)	1.81749522
97	Rhabdomyolysis (HP:0003201)	1.80309776
98	Median cleft lip (HP:0000161)	1.80249720
99	Abnormality of the hepatic vasculature (HP:0006707)	1.79946945
100	Bell-shaped thorax (HP:0001591)	1.79615636

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIM2	8.76257398
2	ARAF	4.41070471
3	DYRK1B	3.04805206
4	MAP3K10	2.92827554
5	LMTK2	2.91731068
6	DDR2	2.79016648
7	PRKD3	2.78316561
8	TESK1	2.42949353
9	TAOK3	2.09418150
10	PLK4	2.06827733
11	MAP4K2	2.06272398
12	BRAF	2.04352994
13	STK38	1.94077560
14	TEC	1.79251076
15	STK38L	1.78560144
16	PLK2	1.73355359
17	MAP2K7	1.61304741
18	MAP3K4	1.50801792
19	ADRBK2	1.30459224
20	PHKG2	1.20856037
21	PHKG1	1.20856037
22	MAPK13	1.19321605
23	TNK2	1.17338838
24	INSRR	1.16442993
25	MARK1	1.12656412
26	MKNK2	1.10848546
27	DYRK3	1.03773660
28	RPS6KA2	1.00127120
29	TAOK1	0.99799950
30	PRKCG	0.99707002
31	CDK6	0.98806744
32	CAMKK2	0.97989296
33	PTK2B	0.94981663
34	MAP3K5	0.93976952
35	ZAK	0.93070386
36	PIM1	0.91975542
37	RAF1	0.89481315
38	PRKCE	0.88391650
39	RPS6KC1	0.85884984
40	RPS6KL1	0.85884984
41	PRKG2	0.84374765
42	RPS6KA6	0.83695131
43	TRIM28	0.79890058
44	FLT3	0.79802412
45	WNK3	0.76536925
46	CSF1R	0.72320231
47	FRK	0.70938835
48	DAPK3	0.70505281
49	GRK5	0.69975132
50	NUAK1	0.67997597
51	CAMK1G	0.67178676
52	PKN2	0.65369869
53	MAPK15	0.64327174
54	EIF2AK1	0.63814268
55	ABL2	0.62048081
56	GRK7	0.61787040
57	ACVR1B	0.58959406
58	PNCK	0.58507005
59	PRKCI	0.57442257
60	ERBB3	0.54847201
61	PKN1	0.53239448
62	BMPR1B	0.52919743
63	BMX	0.49051499
64	ERBB2	0.48929187
65	DYRK2	0.47682036
66	BRSK2	0.46616881
67	CAMK2G	0.46612263
68	NTRK2	0.45300874
69	NTRK3	0.44531783
70	GRK1	0.43775125
71	CDK14	0.43388450
72	CDK9	0.43027197
73	MAP2K4	0.42968334
74	DYRK1A	0.42959988
75	CAMK2A	0.41365610
76	STK11	0.40057392
77	RPS6KA1	0.38272803
78	GRK6	0.37294346
79	MARK2	0.36722276
80	PDK1	0.36713761
81	MAPK10	0.36294818
82	PRKD1	0.35852439
83	PRKG1	0.34577370
84	LATS2	0.32470153
85	PRKACA	0.32387216
86	SRPK1	0.32007692
87	PDGFRA	0.31307080
88	MKNK1	0.30604996
89	PRKCH	0.28992134
90	FGFR2	0.28841083
91	PDPK1	0.28639431
92	CAMK4	0.28136617
93	MUSK	0.27344080
94	EGFR	0.26487901
95	WNK1	0.25654745
96	PRKCA	0.24959758
97	CHUK	0.24763493
98	PRKCB	0.24694210
99	MAPK4	0.23861423
100	AKT3	0.23460958

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Renin-angiotensin system_Homo sapiens_hsa04614	4.42124531
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.79075015
3	beta-Alanine metabolism_Homo sapiens_hsa00410	3.06876038
4	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.64265136
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.62944258
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.55917126
7	Nicotine addiction_Homo sapiens_hsa05033	2.50563836
8	Morphine addiction_Homo sapiens_hsa05032	2.20610656
9	Butanoate metabolism_Homo sapiens_hsa00650	2.19804685
10	Olfactory transduction_Homo sapiens_hsa04740	2.14799615
11	Long-term depression_Homo sapiens_hsa04730	2.03644563
12	Taste transduction_Homo sapiens_hsa04742	1.86681495
13	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.77420778
14	Arginine and proline metabolism_Homo sapiens_hsa00330	1.71494225
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.59766244
16	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.53224012
17	GABAergic synapse_Homo sapiens_hsa04727	1.52371666
18	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.49164105
19	Circadian entrainment_Homo sapiens_hsa04713	1.48830830
20	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.47559616
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.45266201
22	Serotonergic synapse_Homo sapiens_hsa04726	1.41348105
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.41264763
24	Fatty acid degradation_Homo sapiens_hsa00071	1.40983973
25	Caffeine metabolism_Homo sapiens_hsa00232	1.40590187
26	ABC transporters_Homo sapiens_hsa02010	1.35080797
27	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.31694659
28	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.29556676
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.25281279
30	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.19093261
31	Phototransduction_Homo sapiens_hsa04744	1.17414380
32	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.13034877
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.08427231
34	Salivary secretion_Homo sapiens_hsa04970	1.07036946
35	Renin secretion_Homo sapiens_hsa04924	1.01913369
36	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.01470847
37	Glutamatergic synapse_Homo sapiens_hsa04724	0.97483234
38	Lysosome_Homo sapiens_hsa04142	0.95598571
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.89070891
40	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.83452758
41	Platelet activation_Homo sapiens_hsa04611	0.81403445
42	Fatty acid metabolism_Homo sapiens_hsa01212	0.80113813
43	PPAR signaling pathway_Homo sapiens_hsa03320	0.79583455
44	Melanoma_Homo sapiens_hsa05218	0.79513328
45	Glycerolipid metabolism_Homo sapiens_hsa00561	0.77052192
46	Endocytosis_Homo sapiens_hsa04144	0.76585256
47	Arginine biosynthesis_Homo sapiens_hsa00220	0.72531336
48	Type I diabetes mellitus_Homo sapiens_hsa04940	0.71792224
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.68334575
50	Sulfur relay system_Homo sapiens_hsa04122	0.68010940
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.66742475
52	Phagosome_Homo sapiens_hsa04145	0.66024397
53	Type II diabetes mellitus_Homo sapiens_hsa04930	0.65875956
54	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.65032169
55	ErbB signaling pathway_Homo sapiens_hsa04012	0.64451253
56	Glioma_Homo sapiens_hsa05214	0.63703927
57	Other glycan degradation_Homo sapiens_hsa00511	0.63394144
58	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62030979
59	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.54792179
60	cAMP signaling pathway_Homo sapiens_hsa04024	0.54267100
61	Choline metabolism in cancer_Homo sapiens_hsa05231	0.54136489
62	Antigen processing and presentation_Homo sapiens_hsa04612	0.53562506
63	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.51748760
64	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.51240254
65	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.51028580
66	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.50698873
67	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50082387
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.48786032
69	Bladder cancer_Homo sapiens_hsa05219	0.48178098
70	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.48060942
71	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.47365858
72	Allograft rejection_Homo sapiens_hsa05330	0.47207835
73	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.47206398
74	Alcoholism_Homo sapiens_hsa05034	0.45617211
75	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.45607884
76	Sphingolipid metabolism_Homo sapiens_hsa00600	0.44049430
77	Gap junction_Homo sapiens_hsa04540	0.42551987
78	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.42082777
79	Graft-versus-host disease_Homo sapiens_hsa05332	0.41795832
80	Cholinergic synapse_Homo sapiens_hsa04725	0.40480208
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40025641
82	Histidine metabolism_Homo sapiens_hsa00340	0.39747919
83	Retinol metabolism_Homo sapiens_hsa00830	0.39334109
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.38107993
85	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.37544346
86	Chemokine signaling pathway_Homo sapiens_hsa04062	0.36873418
87	Bile secretion_Homo sapiens_hsa04976	0.35641753
88	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.34224656
89	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.33204401
90	Gastric acid secretion_Homo sapiens_hsa04971	0.32321913
91	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.30233029
92	VEGF signaling pathway_Homo sapiens_hsa04370	0.29983369
93	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.26258923
94	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.24687304
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.24463076
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.23578853
97	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.23471813
98	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.23205292
99	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.23185859
100	Pancreatic secretion_Homo sapiens_hsa04972	0.21673173

RHBDF1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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