RHBDL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein similar to Rhomboid in Drosophila which is involved in signalling in the Spitz/epidermal growth factor receptor/mitogen-activated protein kinase pathway. The Rhomboid family of proteins consists of intramembrane serine proteases containing several transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.06403515
2synaptic vesicle maturation (GO:0016188)6.05490986
3locomotory exploration behavior (GO:0035641)5.55361238
4vocalization behavior (GO:0071625)5.49762163
5synaptic vesicle exocytosis (GO:0016079)5.37049109
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.25501758
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.22144349
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.10011620
9glutamate secretion (GO:0014047)5.02301226
10regulation of glutamate receptor signaling pathway (GO:1900449)4.75802750
11regulation of synaptic vesicle exocytosis (GO:2000300)4.72421777
12neurotransmitter secretion (GO:0007269)4.49521410
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.47671474
14protein localization to synapse (GO:0035418)4.46998654
15regulation of synapse maturation (GO:0090128)4.43869178
16regulation of neuronal synaptic plasticity (GO:0048168)4.37699998
17exploration behavior (GO:0035640)4.35579964
18proline transport (GO:0015824)4.32488321
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.32333719
20neuronal action potential propagation (GO:0019227)4.25760438
21activation of protein kinase A activity (GO:0034199)4.25546403
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.25332662
23regulation of synaptic vesicle transport (GO:1902803)4.24381164
24layer formation in cerebral cortex (GO:0021819)4.20749989
25regulation of synapse structural plasticity (GO:0051823)4.15445167
26amino acid import (GO:0043090)4.10418039
27gamma-aminobutyric acid transport (GO:0015812)4.09952768
28neuron cell-cell adhesion (GO:0007158)4.02923681
29cellular potassium ion homeostasis (GO:0030007)3.99672450
30synaptic transmission, glutamatergic (GO:0035249)3.95016634
31L-amino acid import (GO:0043092)3.92902399
32long-term memory (GO:0007616)3.86511486
33neurotransmitter-gated ion channel clustering (GO:0072578)3.84383295
34dendritic spine morphogenesis (GO:0060997)3.82557490
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.77429797
36glutamate receptor signaling pathway (GO:0007215)3.71361125
37cytoskeletal anchoring at plasma membrane (GO:0007016)3.70539587
38mitochondrion transport along microtubule (GO:0047497)3.64086652
39establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.64086652
40sodium ion export (GO:0071436)3.63241014
41establishment of mitochondrion localization (GO:0051654)3.63221733
42neuron-neuron synaptic transmission (GO:0007270)3.59618240
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55320869
44synaptic vesicle endocytosis (GO:0048488)3.54841474
45neurotransmitter transport (GO:0006836)3.53256648
46positive regulation of dendritic spine morphogenesis (GO:0061003)3.52320159
47axon ensheathment in central nervous system (GO:0032291)3.50457282
48central nervous system myelination (GO:0022010)3.50457282
49positive regulation of membrane potential (GO:0045838)3.49198339
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48964150
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.46873060
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46728765
53positive regulation of synapse maturation (GO:0090129)3.46554368
54glycine transport (GO:0015816)3.45973409
55cell communication by electrical coupling (GO:0010644)3.44218929
56neuron recognition (GO:0008038)3.37565990
57regulation of neurotransmitter levels (GO:0001505)3.34700463
58regulation of synaptic plasticity (GO:0048167)3.33957906
59neuromuscular process controlling posture (GO:0050884)3.29593387
60transmission of nerve impulse (GO:0019226)3.28892107
61regulation of vesicle fusion (GO:0031338)3.28355865
62regulation of postsynaptic membrane potential (GO:0060078)3.28198952
63regulation of ARF GTPase activity (GO:0032312)3.28133928
64neuromuscular process controlling balance (GO:0050885)3.26571489
65positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.24898170
66negative regulation of dendrite morphogenesis (GO:0050774)3.20782968
67potassium ion homeostasis (GO:0055075)3.20020663
68activation of Rac GTPase activity (GO:0032863)3.18248905
69dicarboxylic acid transport (GO:0006835)3.18035447
70regulation of dendritic spine morphogenesis (GO:0061001)3.17286470
71negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.16439625
72regulation of neurotransmitter secretion (GO:0046928)3.13641230
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.11051551
74positive regulation of protein dephosphorylation (GO:0035307)3.10891162
75positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09502192
76auditory behavior (GO:0031223)3.05371506
77cerebellar Purkinje cell differentiation (GO:0021702)3.05182817
78dendritic spine organization (GO:0097061)3.04296714
79peptidyl-tyrosine autophosphorylation (GO:0038083)3.04156937
80postsynaptic membrane organization (GO:0001941)3.03577928
81response to auditory stimulus (GO:0010996)3.02314889
82dendrite morphogenesis (GO:0048813)3.02037657
83long-term synaptic potentiation (GO:0060291)3.01055285
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00426840
85axonal fasciculation (GO:0007413)2.99383180
86behavioral fear response (GO:0001662)2.99069970
87behavioral defense response (GO:0002209)2.99069970
88chemosensory behavior (GO:0007635)2.97505435
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.97334339
90regulation of synaptic transmission, glutamatergic (GO:0051966)2.96279331
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94369218
92alanine transport (GO:0032328)2.93526437
93positive regulation of dendritic spine development (GO:0060999)2.92989434
94negative regulation of synaptic transmission, GABAergic (GO:0032229)2.92225248
95gamma-aminobutyric acid signaling pathway (GO:0007214)2.91774032
96membrane hyperpolarization (GO:0060081)2.91590137
97membrane depolarization (GO:0051899)2.88930140
98clathrin coat assembly (GO:0048268)2.86946506
99regulation of neurotransmitter transport (GO:0051588)2.86045603
100regulation of voltage-gated calcium channel activity (GO:1901385)2.84940931
101regulation of synaptic transmission (GO:0050804)2.84635990
102potassium ion import (GO:0010107)2.84260911
103cell-cell junction maintenance (GO:0045217)2.84241676
104membrane depolarization during action potential (GO:0086010)2.83748803
105regulation of dendritic spine development (GO:0060998)2.83068554
106fear response (GO:0042596)2.82771128
107cellular sodium ion homeostasis (GO:0006883)2.82384907
108positive regulation of synaptic transmission (GO:0050806)2.82230652
109neuronal ion channel clustering (GO:0045161)2.82150363
110learning (GO:0007612)2.82094218
111prepulse inhibition (GO:0060134)2.81931747
112social behavior (GO:0035176)2.81930894
113intraspecies interaction between organisms (GO:0051703)2.81930894
114cell migration in hindbrain (GO:0021535)2.81660854
115G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.81520584
116synaptic transmission (GO:0007268)2.80941974
117regulation of ARF protein signal transduction (GO:0032012)2.80104392
118positive regulation of fibroblast migration (GO:0010763)2.78124380
119positive regulation of dendrite development (GO:1900006)2.77860611
120positive regulation of neurotransmitter transport (GO:0051590)2.77703227
121semaphorin-plexin signaling pathway (GO:0071526)2.77361462
122cerebellar granule cell differentiation (GO:0021707)2.77334551
123mating behavior (GO:0007617)2.76994656
124positive regulation of neurotransmitter secretion (GO:0001956)2.76556584
125dopamine receptor signaling pathway (GO:0007212)2.76319380
126cerebellar Purkinje cell layer development (GO:0021680)2.76004325
127positive regulation of protein sumoylation (GO:0033235)2.75983728
128innervation (GO:0060384)2.75907487
129acid secretion (GO:0046717)2.70553394
130myelin maintenance (GO:0043217)2.69897615
131entrainment of circadian clock by photoperiod (GO:0043153)2.66571891
132vesicle docking involved in exocytosis (GO:0006904)2.66422465
133acidic amino acid transport (GO:0015800)2.65590231
134establishment of synaptic vesicle localization (GO:0097480)2.63346284
135synaptic vesicle transport (GO:0048489)2.63346284
136detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.63016095
137detection of temperature stimulus involved in sensory perception (GO:0050961)2.63016095
138regulation of dendrite morphogenesis (GO:0048814)2.59855905

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.75800162
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15936657
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13018453
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01468073
5GBX2_23144817_ChIP-Seq_PC3_Human2.90509173
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.87665331
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76884826
8REST_21632747_ChIP-Seq_MESCs_Mouse2.76099723
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76056316
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76056316
11DROSHA_22980978_ChIP-Seq_HELA_Human2.72161897
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.70608848
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.67659957
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.66597887
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59644651
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57341721
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52464003
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.50016547
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.44470185
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.39226003
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37627426
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.36647250
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.33997321
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22927780
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20383604
26* P68_20966046_ChIP-Seq_HELA_Human2.15447559
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.15078802
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.14551264
29TP63_17297297_ChIP-ChIP_HaCaT_Human2.10352466
30RACK7_27058665_Chip-Seq_MCF-7_Human2.07428353
31RARG_19884340_ChIP-ChIP_MEFs_Mouse2.07380235
32KDM2B_26808549_Chip-Seq_DND41_Human2.05542337
33ESR2_21235772_ChIP-Seq_MCF-7_Human2.03198132
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.98360691
35* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93073400
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92819679
37* TET1_21451524_ChIP-Seq_MESCs_Mouse1.92643347
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.87160902
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81590593
40VDR_21846776_ChIP-Seq_THP-1_Human1.79099772
41CREB1_26743006_Chip-Seq_LNCaP_Human1.77243986
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.75655226
43AR_21572438_ChIP-Seq_LNCaP_Human1.71309270
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.69856325
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.67251959
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.65208724
47TCF7_22412390_ChIP-Seq_EML_Mouse1.64367656
48* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.64122888
49* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.63536158
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58331845
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.58090386
52CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.50609051
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48750359
54* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.48424260
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47009272
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46662698
57ZNF263_19887448_ChIP-Seq_K562_Human1.43942352
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.42536238
59MYC_22102868_ChIP-Seq_BL_Human1.41324120
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40001489
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.39271818
62KDM2B_26808549_Chip-Seq_K562_Human1.39068448
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37998490
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37659902
65* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37544352
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.37536314
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.34522756
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33739294
69BCOR_27268052_Chip-Seq_Bcells_Human1.32959516
70ZNF274_21170338_ChIP-Seq_K562_Hela1.31527091
71SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.31021293
72OCT4_19829295_ChIP-Seq_ESCs_Human1.30746859
73SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.30007884
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27785979
75SMAD4_21799915_ChIP-Seq_A2780_Human1.25220987
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24318442
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23065341
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22950929
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20233533
80* SA1_27219007_Chip-Seq_Bcells_Human1.19329024
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18960554
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18453036
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18034332
84BCL6_27268052_Chip-Seq_Bcells_Human1.17870852
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17637226
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17466428
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17217740
88RARA_24833708_ChIP-Seq_LIVER_Mouse1.17167800
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17112681
90* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15632377
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.15322799
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14389173
93TAF15_26573619_Chip-Seq_HEK293_Human1.13465848
94PHF8_20622854_ChIP-Seq_HELA_Human1.13302103
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13271418
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13150892
97AR_19668381_ChIP-Seq_PC3_Human1.12751969
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11106144
99AR_25329375_ChIP-Seq_VCAP_Human1.10485503
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10013241
101RUNX1_27514584_Chip-Seq_MCF-7_Human1.09903428
102RARB_24833708_ChIP-Seq_LIVER_Mouse1.09584787
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09324339
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08926813
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08429980
106* TP63_22573176_ChIP-Seq_HFKS_Human1.08322352
107E2F1_20622854_ChIP-Seq_HELA_Human1.08288531
108ESR1_21235772_ChIP-Seq_MCF-7_Human1.08193938
109TP53_22127205_ChIP-Seq_IMR90_Human1.06333340
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06143767
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.05424194
112* CTCF_27219007_Chip-Seq_Bcells_Human1.02741711
113ETS1_21867929_ChIP-Seq_TH2_Mouse1.02628774
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02583969
115P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02277486
116* FOXP1_21924763_ChIP-Seq_HESCs_Human1.01125666
117KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00603740
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99637898
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.98177188
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96928563
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.96430893
122CBX2_27304074_Chip-Seq_ESCs_Mouse0.94218305
123AHR_22903824_ChIP-Seq_MCF-7_Human0.94164577
124STAT3_23295773_ChIP-Seq_U87_Human0.92779403
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92689450
126SMAD3_21741376_ChIP-Seq_EPCs_Human0.92510163
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91830853
128* LXR_22292898_ChIP-Seq_THP-1_Human0.90892410
129ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90759940
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90126776
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.89501350
132RXR_22108803_ChIP-Seq_LS180_Human0.89348039
133P300_19829295_ChIP-Seq_ESCs_Human0.89256918
134TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88906262
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.88604046
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.87893330
137KLF4_19829295_ChIP-Seq_ESCs_Human0.86822747
138YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86342548
139P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85762738
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85410270
141SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84003562
142BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83574245
143SMC4_20622854_ChIP-Seq_HELA_Human0.82869040
144* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82051212
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.81500979
146OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79017556
147TCF4_23295773_ChIP-Seq_U87_Human0.78777421
148ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78619926
149PRDM14_20953172_ChIP-Seq_ESCs_Human0.78235576
150DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77704838
151* TP53_20018659_ChIP-ChIP_R1E_Mouse0.77538115
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77367844
153BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76933590
154GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76884484
155TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.76747997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.63030828
2MP0003880_abnormal_central_pattern4.23929275
3MP0003635_abnormal_synaptic_transmissio4.21628645
4MP0009745_abnormal_behavioral_response3.45991344
5MP0004270_analgesia3.40594381
6MP0002063_abnormal_learning/memory/cond3.33017980
7MP0002064_seizures3.16654225
8MP0009046_muscle_twitch3.08973539
9MP0001968_abnormal_touch/_nociception2.83393523
10MP0002572_abnormal_emotion/affect_behav2.72249472
11MP0002822_catalepsy2.67199025
12MP0005423_abnormal_somatic_nervous2.60232826
13MP0002272_abnormal_nervous_system2.59995418
14MP0001501_abnormal_sleep_pattern2.54714788
15MP0002734_abnormal_mechanical_nocicepti2.48165611
16MP0001486_abnormal_startle_reflex2.43573891
17MP0002735_abnormal_chemical_nociception2.32292358
18MP0001348_abnormal_lacrimal_gland2.24032420
19MP0002736_abnormal_nociception_after2.18016924
20MP0009780_abnormal_chondrocyte_physiolo2.16629130
21MP0003329_amyloid_beta_deposits2.14335280
22MP0001440_abnormal_grooming_behavior2.10864936
23MP0002733_abnormal_thermal_nociception2.01144770
24MP0001970_abnormal_pain_threshold1.96732140
25MP0004858_abnormal_nervous_system1.93840643
26MP0005409_darkened_coat_color1.91982833
27MP0002909_abnormal_adrenal_gland1.88320949
28MP0000566_synostosis1.88156497
29MP0008569_lethality_at_weaning1.87044026
30MP0003705_abnormal_hypodermis_morpholog1.85190987
31MP0002067_abnormal_sensory_capabilities1.80616973
32MP0003879_abnormal_hair_cell1.80288494
33MP0001188_hyperpigmentation1.79042538
34MP0002557_abnormal_social/conspecific_i1.71392242
35MP0004811_abnormal_neuron_physiology1.71362356
36MP0006276_abnormal_autonomic_nervous1.71169512
37MP0003123_paternal_imprinting1.70828198
38MP0004924_abnormal_behavior1.70107090
39MP0005386_behavior/neurological_phenoty1.70107090
40MP0002184_abnormal_innervation1.62215746
41MP0005646_abnormal_pituitary_gland1.58692809
42MP0000955_abnormal_spinal_cord1.55371698
43MP0000778_abnormal_nervous_system1.53990077
44MP0003122_maternal_imprinting1.53611336
45MP0002249_abnormal_larynx_morphology1.51321139
46MP0001346_abnormal_lacrimal_gland1.50152268
47MP0000751_myopathy1.48187739
48MP0001984_abnormal_olfaction1.45274176
49MP0004885_abnormal_endolymph1.45052582
50MP0002066_abnormal_motor_capabilities/c1.42664887
51MP0003787_abnormal_imprinting1.41920427
52MP0000013_abnormal_adipose_tissue1.40528202
53MP0004130_abnormal_muscle_cell1.39927815
54MP0005645_abnormal_hypothalamus_physiol1.37075514
55MP0002882_abnormal_neuron_morphology1.34414509
56MP0003633_abnormal_nervous_system1.32886623
57MP0004142_abnormal_muscle_tone1.29059390
58MP0008872_abnormal_physiological_respon1.28917829
59MP0001502_abnormal_circadian_rhythm1.27673789
60MP0005058_abnormal_lysosome_morphology1.24280114
61MP0008961_abnormal_basal_metabolism1.22397348
62MP0005535_abnormal_body_temperature1.20613219
63MP0002837_dystrophic_cardiac_calcinosis1.19720819
64MP0001529_abnormal_vocalization1.18516720
65MP0005360_urolithiasis1.13364580
66MP0004145_abnormal_muscle_electrophysio1.12687770
67MP0001905_abnormal_dopamine_level1.11048867
68MP0000678_abnormal_parathyroid_gland1.10373001
69MP0002876_abnormal_thyroid_physiology1.09253091
70MP0005076_abnormal_cell_differentiation1.09244858
71MP0003690_abnormal_glial_cell1.08975984
72MP0003631_nervous_system_phenotype1.07363205
73MP0003075_altered_response_to1.06640117
74MP0002069_abnormal_eating/drinking_beha1.06585464
75MP0000604_amyloidosis1.04049027
76MP0001986_abnormal_taste_sensitivity1.03497457
77MP0008874_decreased_physiological_sensi1.01402216
78MP0001849_ear_inflammation0.99514760
79MP0005499_abnormal_olfactory_system0.97836151
80MP0005394_taste/olfaction_phenotype0.97836151
81MP0000579_abnormal_nail_morphology0.97454578
82MP0002152_abnormal_brain_morphology0.94908710
83MP0008260_abnormal_autophagy0.94277188
84MP0002229_neurodegeneration0.93967883
85MP0000537_abnormal_urethra_morphology0.87455074
86MP0002638_abnormal_pupillary_reflex0.85527233
87MP0003283_abnormal_digestive_organ0.85016313
88MP0004742_abnormal_vestibular_system0.81144388
89MP0003634_abnormal_glial_cell0.79411667
90MP0004185_abnormal_adipocyte_glucose0.77363058
91MP0010386_abnormal_urinary_bladder0.76543295
92MP0004085_abnormal_heartbeat0.74450958
93MP0001177_atelectasis0.74040753
94MP0009384_cardiac_valve_regurgitation0.72754637
95MP0003632_abnormal_nervous_system0.72054053
96MP0001963_abnormal_hearing_physiology0.69982435
97MP0005375_adipose_tissue_phenotype0.69600370
98MP0005448_abnormal_energy_balance0.68901688
99MP0000747_muscle_weakness0.68012512
100MP0003115_abnormal_respiratory_system0.67234298
101MP0000920_abnormal_myelination0.67134100
102MP0004215_abnormal_myocardial_fiber0.65608132
103MP0004233_abnormal_muscle_weight0.64635138
104MP0004381_abnormal_hair_follicle0.63839737
105MP0010234_abnormal_vibrissa_follicle0.63515001
106MP0002090_abnormal_vision0.63089923
107MP0005167_abnormal_blood-brain_barrier0.62895058
108MP0001664_abnormal_digestion0.62825205
109MP0003861_abnormal_nervous_system0.62600031
110MP0003137_abnormal_impulse_conducting0.61629461
111MP0001765_abnormal_ion_homeostasis0.61551247
112MP0002752_abnormal_somatic_nervous0.60216388
113MP0002873_normal_phenotype0.59924183
114MP0005666_abnormal_adipose_tissue0.59585614
115MP0002169_no_abnormal_phenotype0.59218795
116MP0004484_altered_response_of0.58890881
117MP0010769_abnormal_survival0.58133778
118MP0010768_mortality/aging0.56145512
119MP0003953_abnormal_hormone_level0.55119071
120MP0005623_abnormal_meninges_morphology0.55071178
121MP0003942_abnormal_urinary_system0.54041898
122MP0005551_abnormal_eye_electrophysiolog0.53520903
123MP0000003_abnormal_adipose_tissue0.53413588
124MP0005670_abnormal_white_adipose0.52694635
125MP0003956_abnormal_body_size0.52506918
126MP0000639_abnormal_adrenal_gland0.52396165
127MP0000026_abnormal_inner_ear0.51982488
128MP0002078_abnormal_glucose_homeostasis0.51971984
129MP0003172_abnormal_lysosome_physiology0.51911468
130MP0005620_abnormal_muscle_contractility0.51892363
131MP0003646_muscle_fatigue0.51371542
132MP0010329_abnormal_lipoprotein_level0.49732522
133MP0002089_abnormal_postnatal_growth/wei0.49265582

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.82628909
2Focal motor seizures (HP:0011153)6.79650703
3Visual hallucinations (HP:0002367)5.96683767
4Focal seizures (HP:0007359)5.33969202
5Epileptic encephalopathy (HP:0200134)4.26408673
6Progressive cerebellar ataxia (HP:0002073)4.19403454
7Atonic seizures (HP:0010819)4.07627017
8Action tremor (HP:0002345)3.98263489
9Febrile seizures (HP:0002373)3.92299905
10Absence seizures (HP:0002121)3.86817562
11Supranuclear gaze palsy (HP:0000605)3.85658706
12Generalized tonic-clonic seizures (HP:0002069)3.71781176
13Ankle clonus (HP:0011448)3.63252012
14Dialeptic seizures (HP:0011146)3.49453915
15Depression (HP:0000716)3.46429417
16Impaired vibration sensation in the lower limbs (HP:0002166)3.44231685
17Abnormal eating behavior (HP:0100738)3.34402800
18Anxiety (HP:0000739)3.32362504
19Poor eye contact (HP:0000817)3.23431636
20Upper limb amyotrophy (HP:0009129)3.20580862
21Distal upper limb amyotrophy (HP:0007149)3.20580862
22Impaired social interactions (HP:0000735)3.14450257
23Abnormal social behavior (HP:0012433)3.14450257
24Abnormality of the lower motor neuron (HP:0002366)3.13766561
25Stridor (HP:0010307)3.06927210
26Mutism (HP:0002300)3.06398600
27Focal dystonia (HP:0004373)3.06353390
28Dysdiadochokinesis (HP:0002075)3.04785531
29Dysmetria (HP:0001310)3.01780780
30Broad-based gait (HP:0002136)3.01045017
31Torticollis (HP:0000473)2.99488048
32Postural instability (HP:0002172)2.98709131
33Urinary bladder sphincter dysfunction (HP:0002839)2.94885407
34Cerebral inclusion bodies (HP:0100314)2.91193940
35Hyperacusis (HP:0010780)2.82856272
36Papilledema (HP:0001085)2.82341233
37Turricephaly (HP:0000262)2.80836372
38Polyphagia (HP:0002591)2.80034905
39Hemiplegia (HP:0002301)2.73037923
40Spinal canal stenosis (HP:0003416)2.72296527
41Hand muscle atrophy (HP:0009130)2.70938655
42Craniofacial dystonia (HP:0012179)2.70834121
43Oligomenorrhea (HP:0000876)2.70574972
44Bradykinesia (HP:0002067)2.69258377
45Truncal ataxia (HP:0002078)2.68476279
46Abnormality of the corticospinal tract (HP:0002492)2.66135223
47Neurofibrillary tangles (HP:0002185)2.64799373
48Megalencephaly (HP:0001355)2.62371857
49Gaze-evoked nystagmus (HP:0000640)2.61162417
50Amblyopia (HP:0000646)2.60937174
51Urinary urgency (HP:0000012)2.59193303
52Spastic gait (HP:0002064)2.56075365
53Intention tremor (HP:0002080)2.53499545
54Progressive inability to walk (HP:0002505)2.52115003
55Ulnar bowing (HP:0003031)2.51274312
56Genetic anticipation (HP:0003743)2.50731658
57Impaired smooth pursuit (HP:0007772)2.50000140
58Status epilepticus (HP:0002133)2.48274909
59Diplopia (HP:0000651)2.41501517
60Abnormality of binocular vision (HP:0011514)2.41501517
61Biconcave vertebral bodies (HP:0004586)2.41306521
62J-shaped sella turcica (HP:0002680)2.41168613
63Hyperventilation (HP:0002883)2.39696198
64Hemiparesis (HP:0001269)2.38704120
65Sleep apnea (HP:0010535)2.36931406
66Ventricular fibrillation (HP:0001663)2.36862417
67Broad face (HP:0000283)2.31708414
68Cerebral hypomyelination (HP:0006808)2.31427946
69Aplasia involving bones of the extremities (HP:0009825)2.31244529
70Aplasia involving bones of the upper limbs (HP:0009823)2.31244529
71Aplasia of the phalanges of the hand (HP:0009802)2.31244529
72Failure to thrive in infancy (HP:0001531)2.29490200
73Limb dystonia (HP:0002451)2.28471227
74Germ cell neoplasia (HP:0100728)2.28277231
75Thin bony cortex (HP:0002753)2.28199116
76Scanning speech (HP:0002168)2.25870972
77Epileptiform EEG discharges (HP:0011182)2.25539489
78Testicular atrophy (HP:0000029)2.25386436
79Cerebral aneurysm (HP:0004944)2.23265426
80EEG with generalized epileptiform discharges (HP:0011198)2.23074866
81Lower limb amyotrophy (HP:0007210)2.21416190
82Obstructive sleep apnea (HP:0002870)2.21268969
83Tetraplegia (HP:0002445)2.20072914
84Apathy (HP:0000741)2.19623357
85Drooling (HP:0002307)2.19362681
86Excessive salivation (HP:0003781)2.19362681
87Bundle branch block (HP:0011710)2.18779864
88Abnormality of ocular smooth pursuit (HP:0000617)2.18603046
89Insomnia (HP:0100785)2.18512239
90Slow saccadic eye movements (HP:0000514)2.18048252
91Bronchomalacia (HP:0002780)2.17655914
92Impaired vibratory sensation (HP:0002495)2.17041516
93Myotonia (HP:0002486)2.15751990
94Anomalous pulmonary venous return (HP:0010772)2.14188315
95Cholecystitis (HP:0001082)2.12248016
96Abnormal gallbladder physiology (HP:0012438)2.12248016
97Atelectasis (HP:0100750)2.12215981
98Lower limb muscle weakness (HP:0007340)2.11712838
99Pheochromocytoma (HP:0002666)2.11186778
100Agitation (HP:0000713)2.10951607
101Hypsarrhythmia (HP:0002521)2.10378214
102Dysmetric saccades (HP:0000641)2.09706572
103Hypoventilation (HP:0002791)2.07650443
104Delusions (HP:0000746)2.07578139
105Exercise-induced myalgia (HP:0003738)2.07362262
106Rigidity (HP:0002063)2.06642956
107Rapidly progressive (HP:0003678)2.05787392
108Annular pancreas (HP:0001734)2.05687677
109Psychosis (HP:0000709)2.03823901
110Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.01699863
111Stereotypic behavior (HP:0000733)2.01608621
112Amyotrophic lateral sclerosis (HP:0007354)2.00379483
113Nuclear cataract (HP:0100018)2.00281580
114Vertebral compression fractures (HP:0002953)1.99455560
115Achilles tendon contracture (HP:0001771)1.98788162
116Truncus arteriosus (HP:0001660)1.98448796
117Abnormal EKG (HP:0003115)1.97465959
118Pointed chin (HP:0000307)1.96509414
119Fetal akinesia sequence (HP:0001989)1.94497099
120Generalized myoclonic seizures (HP:0002123)1.93627632
121Diminished motivation (HP:0000745)1.92583394
122Neuronal loss in central nervous system (HP:0002529)1.92069796
123Clonus (HP:0002169)1.90543082
124Poor suck (HP:0002033)1.89425792
125Axonal loss (HP:0003447)1.87874777
126Incomplete penetrance (HP:0003829)1.87811713
127Abnormal atrioventricular conduction (HP:0005150)1.87387292
128Termporal pattern (HP:0011008)1.86842986
129Insidious onset (HP:0003587)1.86842986
130Distal sensory impairment (HP:0002936)1.86821529
131Shallow orbits (HP:0000586)1.86393166
132Testicular neoplasm (HP:0010788)1.85827078
133Gait ataxia (HP:0002066)1.85049314
134Hypercortisolism (HP:0001578)1.84432891
135Cervical subluxation (HP:0003308)1.82985430
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.82832630
137Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82832630
138Difficulty climbing stairs (HP:0003551)1.82767768
139Akinesia (HP:0002304)1.82413957
140Abnormality of the Achilles tendon (HP:0005109)1.81900812
141Hyperthyroidism (HP:0000836)1.81519683
142Abnormality of the pulmonary veins (HP:0011718)1.80699650
143Alacrima (HP:0000522)1.80218992
144Lymphangioma (HP:0100764)1.77762473
145Heart block (HP:0012722)1.75587927
146Broad distal phalanx of finger (HP:0009836)1.74940872
147Peripheral hypomyelination (HP:0007182)1.74591102
148Choreoathetosis (HP:0001266)1.73267395
149Mucopolysacchariduria (HP:0008155)1.72272102
150Urinary glycosaminoglycan excretion (HP:0003541)1.72272102
151Abnormality of saccadic eye movements (HP:0000570)1.70582232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.06543777
2MAP4K23.99038925
3EPHA43.86255504
4MAP3K93.80703135
5MARK13.01934970
6MAP3K43.00334397
7MAP2K72.81075294
8MINK12.79977488
9SIK12.74072075
10DAPK22.40592603
11PAK62.28557293
12NTRK22.25419656
13KSR22.04739541
14CAMKK12.04488569
15MAP2K42.01691841
16PRKD32.01132413
17MAP3K121.82937459
18NTRK11.69430031
19CDK51.62493816
20GRK51.57082836
21PHKG21.54967269
22PHKG11.54967269
23TYRO31.54382565
24SIK21.49770447
25DAPK11.39952200
26TRIB31.38074737
27RIPK41.35583016
28PLK21.32286836
29EEF2K1.30920379
30FES1.28741558
31MAP2K61.26559966
32KSR11.26031919
33TAOK11.25680505
34PRKCG1.23047234
35EPHA21.21636788
36STK381.18880327
37MAP3K111.18741685
38CAMK1G1.17748511
39ARAF1.17099126
40MAPK131.16642630
41MAP3K131.16072473
42PRPF4B1.15876306
43LMTK21.13098700
44UHMK11.12094904
45TNIK1.08674722
46PRKCH1.08368264
47CAMKK21.07944801
48CDK121.06690581
49SMG11.03565333
50CAMK11.01254550
51MAP3K21.00135729
52MST1R1.00090947
53CASK0.99843470
54RET0.97944008
55FGFR40.94172887
56GRK60.93226074
57CDK180.92032328
58MAP2K30.91277718
59CDK150.90978474
60LATS20.89023174
61BRAF0.88888573
62SGK2230.88740020
63SGK4940.88740020
64ALK0.88257879
65IRAK20.87750091
66CDK140.87216092
67CAMK1D0.86467542
68CDK190.85669122
69CAMK2A0.82824317
70NEK60.82111175
71TESK10.82008134
72ERN10.81599453
73PDK10.81372657
74PTK2B0.81120163
75TAOK20.80488793
76PAK30.79906682
77TNK20.79075189
78CDK11A0.78703699
79PDPK10.78337466
80MARK20.77719251
81DDR20.76938105
82WNK40.75480631
83PINK10.75313848
84BRSK10.74995090
85STK110.73173615
86PDGFRA0.71412642
87DYRK1A0.70534265
88PTK20.69285243
89SCYL20.69050785
90MAPK150.68545090
91CAMK2B0.67393873
92MAP3K10.64392552
93BMX0.62036734
94IRAK30.61906826
95PRKCI0.61556197
96FGR0.60886944
97PRKCZ0.60550326
98MET0.60444445
99RIPK10.60086979
100CDC42BPA0.60003661
101SGK10.59401621
102NME10.58223096
103CSNK1G20.58192934
104ICK0.56583285
105SGK30.56500658
106MAP3K70.54371954
107CAMK2G0.54365223
108MTOR0.54198639
109PNCK0.53352484
110PRKD20.52302626
111RAF10.49843677
112MAP2K10.49399833
113FER0.48985104
114SGK20.48919713
115MAPK120.48812397
116MAPKAPK50.48484550
117RPS6KA30.48299448
118PKN20.47138653
119MAPK80.46937981
120FYN0.46236880
121WNK10.45761212
122LIMK10.44596182
123RPS6KA20.44185983
124PRKCE0.43642797
125NEK10.41142851
126CAMK2D0.39899480
127MAPK100.39776419
128CAMK40.39701838
129MAP2K20.38973890
130DAPK30.38256000
131RPS6KL10.36626347
132RPS6KC10.36626347
133PRKG20.34904805
134ERBB20.34646523
135PTK60.34239861
136MAP3K60.32408661
137OXSR10.32256012
138PRKACG0.31170711

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.27147525
2Nicotine addiction_Homo sapiens_hsa050333.02731378
3GABAergic synapse_Homo sapiens_hsa047272.62345816
4Circadian entrainment_Homo sapiens_hsa047132.56774841
5Long-term potentiation_Homo sapiens_hsa047202.49769576
6Olfactory transduction_Homo sapiens_hsa047402.44604511
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38929069
8Glutamatergic synapse_Homo sapiens_hsa047242.38176312
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36045909
10Morphine addiction_Homo sapiens_hsa050322.28846963
11Amphetamine addiction_Homo sapiens_hsa050312.16547682
12Salivary secretion_Homo sapiens_hsa049702.15791381
13Dopaminergic synapse_Homo sapiens_hsa047281.98625736
14Gastric acid secretion_Homo sapiens_hsa049711.97278694
15Vitamin B6 metabolism_Homo sapiens_hsa007501.96318357
16Insulin secretion_Homo sapiens_hsa049111.94406230
17Cholinergic synapse_Homo sapiens_hsa047251.88526751
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82011189
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74584675
20Sulfur relay system_Homo sapiens_hsa041221.62751740
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57666699
22Oxytocin signaling pathway_Homo sapiens_hsa049211.56013176
23Renin secretion_Homo sapiens_hsa049241.55145622
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52611746
25Cocaine addiction_Homo sapiens_hsa050301.50768162
26Nitrogen metabolism_Homo sapiens_hsa009101.48669832
27Long-term depression_Homo sapiens_hsa047301.48024527
28Other glycan degradation_Homo sapiens_hsa005111.47918336
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45268019
30Collecting duct acid secretion_Homo sapiens_hsa049661.44834308
31Calcium signaling pathway_Homo sapiens_hsa040201.43927184
32Taste transduction_Homo sapiens_hsa047421.43096692
33GnRH signaling pathway_Homo sapiens_hsa049121.39469070
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.39120552
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36029263
36Serotonergic synapse_Homo sapiens_hsa047261.34741133
37Gap junction_Homo sapiens_hsa045401.34282316
38Type II diabetes mellitus_Homo sapiens_hsa049301.27324103
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.26796102
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23765109
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.20637213
42Estrogen signaling pathway_Homo sapiens_hsa049151.18840281
43cAMP signaling pathway_Homo sapiens_hsa040241.17700583
44Notch signaling pathway_Homo sapiens_hsa043301.16393511
45Glioma_Homo sapiens_hsa052141.08481806
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05105142
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99006197
48ErbB signaling pathway_Homo sapiens_hsa040120.97231499
49Melanogenesis_Homo sapiens_hsa049160.96870514
50Inositol phosphate metabolism_Homo sapiens_hsa005620.95054653
51Cardiac muscle contraction_Homo sapiens_hsa042600.94447299
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92355951
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92016920
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90780576
55Axon guidance_Homo sapiens_hsa043600.90356637
56Vibrio cholerae infection_Homo sapiens_hsa051100.90246232
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.83996815
58Thyroid hormone synthesis_Homo sapiens_hsa049180.83481302
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.81959945
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80824235
61Pancreatic secretion_Homo sapiens_hsa049720.80502399
62Bile secretion_Homo sapiens_hsa049760.79266687
63Fructose and mannose metabolism_Homo sapiens_hsa000510.77331190
64Butanoate metabolism_Homo sapiens_hsa006500.74543752
65ABC transporters_Homo sapiens_hsa020100.72974786
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72493512
67Glucagon signaling pathway_Homo sapiens_hsa049220.72278044
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71100221
69Choline metabolism in cancer_Homo sapiens_hsa052310.69658204
70Biosynthesis of amino acids_Homo sapiens_hsa012300.69386745
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68742680
72Fatty acid biosynthesis_Homo sapiens_hsa000610.68418486
73VEGF signaling pathway_Homo sapiens_hsa043700.67552652
74Dilated cardiomyopathy_Homo sapiens_hsa054140.67445838
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67232090
76Dorso-ventral axis formation_Homo sapiens_hsa043200.66395103
77Oocyte meiosis_Homo sapiens_hsa041140.65389904
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65208300
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.64542879
80Insulin signaling pathway_Homo sapiens_hsa049100.63731267
81Prion diseases_Homo sapiens_hsa050200.62891622
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61075681
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59225327
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58079017
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57273834
86MAPK signaling pathway_Homo sapiens_hsa040100.55663352
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55207223
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54409643
89Chronic myeloid leukemia_Homo sapiens_hsa052200.53267078
90Arginine and proline metabolism_Homo sapiens_hsa003300.53251003
91Glycerolipid metabolism_Homo sapiens_hsa005610.50725216
92Hippo signaling pathway_Homo sapiens_hsa043900.49573769
93Ras signaling pathway_Homo sapiens_hsa040140.47487897
94Non-small cell lung cancer_Homo sapiens_hsa052230.46506605
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46410039
96Alzheimers disease_Homo sapiens_hsa050100.46354380
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46256818
98mTOR signaling pathway_Homo sapiens_hsa041500.44139052
99Endometrial cancer_Homo sapiens_hsa052130.44138657
100Rap1 signaling pathway_Homo sapiens_hsa040150.43306077
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.43048633
102Endocytosis_Homo sapiens_hsa041440.42832609
103Prolactin signaling pathway_Homo sapiens_hsa049170.42146819
104Ovarian steroidogenesis_Homo sapiens_hsa049130.41344882
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38016653
106Wnt signaling pathway_Homo sapiens_hsa043100.36835979
107Phenylalanine metabolism_Homo sapiens_hsa003600.36812968
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36064778
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35847507
110Alcoholism_Homo sapiens_hsa050340.35808092
111Arginine biosynthesis_Homo sapiens_hsa002200.35480796
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.32867493
113Renal cell carcinoma_Homo sapiens_hsa052110.31605041
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30756603
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30389140
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30321266
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.29232365
118Type I diabetes mellitus_Homo sapiens_hsa049400.29134287
119Circadian rhythm_Homo sapiens_hsa047100.28597265
120AMPK signaling pathway_Homo sapiens_hsa041520.28187782
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.27627232

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »