RHBG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.43050033
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.43050033
3L-phenylalanine metabolic process (GO:0006558)6.31478159
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.31478159
5aromatic amino acid family catabolic process (GO:0009074)5.85532010
6sulfur amino acid catabolic process (GO:0000098)5.51439849
7tryptophan catabolic process (GO:0006569)5.42917648
8indole-containing compound catabolic process (GO:0042436)5.42917648
9indolalkylamine catabolic process (GO:0046218)5.42917648
10glyoxylate metabolic process (GO:0046487)5.35747463
11kynurenine metabolic process (GO:0070189)5.23419848
12desmosome organization (GO:0002934)5.20712808
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.14414129
14cellular modified amino acid catabolic process (GO:0042219)5.12659266
15tryptophan metabolic process (GO:0006568)5.02873798
16behavioral response to nicotine (GO:0035095)4.98474334
17cysteine metabolic process (GO:0006534)4.95533718
18serine family amino acid catabolic process (GO:0009071)4.90002911
19phospholipid efflux (GO:0033700)4.77868484
20high-density lipoprotein particle remodeling (GO:0034375)4.73335151
21coenzyme catabolic process (GO:0009109)4.72838053
22bile acid biosynthetic process (GO:0006699)4.72401169
23urea metabolic process (GO:0019627)4.68587383
24urea cycle (GO:0000050)4.68587383
25amino-acid betaine metabolic process (GO:0006577)4.67100424
26intestinal cholesterol absorption (GO:0030299)4.58697471
27drug catabolic process (GO:0042737)4.41042879
28homocysteine metabolic process (GO:0050667)4.39607273
29primary alcohol catabolic process (GO:0034310)4.30278939
30nitrogen cycle metabolic process (GO:0071941)4.28145297
31nephron epithelium morphogenesis (GO:0072088)4.27852816
32nephron tubule morphogenesis (GO:0072078)4.27852816
33aromatic amino acid family metabolic process (GO:0009072)4.27340474
34epoxygenase P450 pathway (GO:0019373)4.27329599
35establishment of skin barrier (GO:0061436)4.23983662
36negative regulation of fibrinolysis (GO:0051918)4.21101224
37lysine catabolic process (GO:0006554)4.17968466
38lysine metabolic process (GO:0006553)4.17968466
39regulation of triglyceride catabolic process (GO:0010896)4.17621779
40protein carboxylation (GO:0018214)4.15993122
41peptidyl-glutamic acid carboxylation (GO:0017187)4.15993122
42regulation of fibrinolysis (GO:0051917)4.11832425
43alpha-linolenic acid metabolic process (GO:0036109)4.10127137
44alpha-amino acid catabolic process (GO:1901606)4.09938313
45regulation of cholesterol esterification (GO:0010872)4.08387224
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.07178363
47reverse cholesterol transport (GO:0043691)4.01958024
48glycine metabolic process (GO:0006544)4.01869713
49cellular amino acid catabolic process (GO:0009063)4.01184642
50urate metabolic process (GO:0046415)4.00798635
51negative regulation of cholesterol transport (GO:0032375)3.98984982
52negative regulation of sterol transport (GO:0032372)3.98984982
53bile acid metabolic process (GO:0008206)3.98566293
54serine family amino acid metabolic process (GO:0009069)3.97419039
55exogenous drug catabolic process (GO:0042738)3.94339407
56hormone catabolic process (GO:0042447)3.91275801
57drug transmembrane transport (GO:0006855)3.88365019
58regulation of water loss via skin (GO:0033561)3.87837143
59regulation of protein activation cascade (GO:2000257)3.86567430
60plasma lipoprotein particle remodeling (GO:0034369)3.84953148
61protein-lipid complex remodeling (GO:0034368)3.84953148
62macromolecular complex remodeling (GO:0034367)3.84953148
63triglyceride homeostasis (GO:0070328)3.84261621
64acylglycerol homeostasis (GO:0055090)3.84261621
65complement activation, alternative pathway (GO:0006957)3.76834693
66water-soluble vitamin biosynthetic process (GO:0042364)3.75860223
67drug metabolic process (GO:0017144)3.75396789
68imidazole-containing compound metabolic process (GO:0052803)3.75210773
69indolalkylamine metabolic process (GO:0006586)3.70686401
70heme transport (GO:0015886)3.69157709
71tyrosine metabolic process (GO:0006570)3.68741769
72carnitine metabolic process (GO:0009437)3.67464401
73glutamate metabolic process (GO:0006536)3.66480015
74DNA deamination (GO:0045006)3.65858219
75negative regulation of lipase activity (GO:0060192)3.65243720
76L-fucose catabolic process (GO:0042355)3.64775275
77fucose catabolic process (GO:0019317)3.64775275
78L-fucose metabolic process (GO:0042354)3.64775275
79amine catabolic process (GO:0009310)3.63914306
80cellular biogenic amine catabolic process (GO:0042402)3.63914306
81benzene-containing compound metabolic process (GO:0042537)3.61608211
82fibrinolysis (GO:0042730)3.60952594
83flavonoid metabolic process (GO:0009812)3.60693965
84linoleic acid metabolic process (GO:0043651)3.59188173
85cellular ketone body metabolic process (GO:0046950)3.59132017
86regulation of complement activation (GO:0030449)3.59023178
87low-density lipoprotein particle remodeling (GO:0034374)3.57901608
88serine family amino acid biosynthetic process (GO:0009070)3.55851151
89regulation of cholesterol homeostasis (GO:2000188)3.55609631
90cellular glucuronidation (GO:0052695)3.53966402
91very-low-density lipoprotein particle assembly (GO:0034379)3.52953062
92cofactor catabolic process (GO:0051187)3.49699153
93arginine metabolic process (GO:0006525)3.49204998
94ethanol oxidation (GO:0006069)3.49002861
95bile acid and bile salt transport (GO:0015721)3.45429593
96organic acid catabolic process (GO:0016054)3.43899517
97carboxylic acid catabolic process (GO:0046395)3.43899517
98short-chain fatty acid metabolic process (GO:0046459)3.42650750
99plasma lipoprotein particle clearance (GO:0034381)3.40905298
100plasma lipoprotein particle assembly (GO:0034377)3.40267586
101very long-chain fatty acid metabolic process (GO:0000038)3.39487386
102cholesterol efflux (GO:0033344)3.36430603
103ethanol metabolic process (GO:0006067)3.35347771
104C4-dicarboxylate transport (GO:0015740)3.33235889
105positive regulation of lipoprotein lipase activity (GO:0051006)3.30083474
106positive regulation of triglyceride lipase activity (GO:0061365)3.30083474
107aminoglycoside antibiotic metabolic process (GO:0030647)3.29551685
108drug transport (GO:0015893)3.28841926
109cholesterol homeostasis (GO:0042632)3.22070705
110valine metabolic process (GO:0006573)3.20177252
111regulation of glucokinase activity (GO:0033131)3.19862449
112regulation of hexokinase activity (GO:1903299)3.19862449
113glucuronate metabolic process (GO:0019585)3.18851837
114uronic acid metabolic process (GO:0006063)3.18851837
115branched-chain amino acid catabolic process (GO:0009083)3.18828889
116plasma lipoprotein particle organization (GO:0071827)3.18129955
117detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.17993309
118detection of light stimulus involved in visual perception (GO:0050908)3.11303752
119detection of light stimulus involved in sensory perception (GO:0050962)3.11303752
120renal tubule morphogenesis (GO:0061333)3.11202544
121protein localization to cilium (GO:0061512)3.05464825
122mannosylation (GO:0097502)3.05132682
123epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01945369
124peptidyl-glutamic acid modification (GO:0018200)2.98450214
125piRNA metabolic process (GO:0034587)2.93243027
126ketone body metabolic process (GO:1902224)2.91091350
127gamma-aminobutyric acid transport (GO:0015812)2.90087700
128S-adenosylmethionine metabolic process (GO:0046500)2.87541524
129intestinal absorption (GO:0050892)2.85851487
130protein polyglutamylation (GO:0018095)2.84263263
131blood coagulation, intrinsic pathway (GO:0007597)2.80087058
132negative regulation of astrocyte differentiation (GO:0048712)2.78351636
133alanine transport (GO:0032328)2.74966026
1343-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.74589368
135purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.74589368
136neurotransmitter-gated ion channel clustering (GO:0072578)2.74487060
137protein-cofactor linkage (GO:0018065)2.71907785
138peristalsis (GO:0030432)2.70487403
139platelet dense granule organization (GO:0060155)2.70260696
140protein-lipid complex subunit organization (GO:0071825)2.69405896
141basic amino acid transport (GO:0015802)2.67083841
142indole-containing compound metabolic process (GO:0042430)2.64161180
143protein complex biogenesis (GO:0070271)2.63996082
144response to pheromone (GO:0019236)2.60726944
145negative regulation of telomere maintenance (GO:0032205)2.59476263
146sulfation (GO:0051923)2.56280241
147sperm motility (GO:0030317)2.54199861
148regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.53544258
149primary amino compound metabolic process (GO:1901160)2.52033373
150regulation of non-canonical Wnt signaling pathway (GO:2000050)2.51542412
151epithelial cilium movement (GO:0003351)2.50551351
152mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.48843387
153mitochondrial respiratory chain complex I assembly (GO:0032981)2.48843387
154NADH dehydrogenase complex assembly (GO:0010257)2.48843387
155protein-lipid complex assembly (GO:0065005)2.48480407
156behavioral response to ethanol (GO:0048149)2.48171220
157mitochondrial respiratory chain complex assembly (GO:0033108)2.45982375
158NAD biosynthetic process (GO:0009435)2.44233909
159positive regulation of glycolytic process (GO:0045821)2.43753593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.46016018
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.89091115
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.11030597
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.52108834
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.75644096
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.63238121
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.28683143
8ZNF274_21170338_ChIP-Seq_K562_Hela4.20230194
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.91332970
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.79205213
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.47440021
12VDR_22108803_ChIP-Seq_LS180_Human3.33460189
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.23768530
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.96425072
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.86519322
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.86519322
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.86519322
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.64383237
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49882395
20IGF1R_20145208_ChIP-Seq_DFB_Human2.42180062
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.37214929
22GBX2_23144817_ChIP-Seq_PC3_Human2.29704660
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.24430809
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20095108
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10193680
26ESR1_21235772_ChIP-Seq_MCF-7_Human2.10133390
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98323266
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.94494200
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86341429
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84960736
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83724243
32P63_26484246_Chip-Seq_KERATINOCYTES_Human1.81916067
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77183357
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75829709
35EZH2_22144423_ChIP-Seq_EOC_Human1.74084868
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70039370
37P300_19829295_ChIP-Seq_ESCs_Human1.69570893
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.68328568
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66733902
40CDX2_20551321_ChIP-Seq_CACO-2_Human1.64084582
41ER_23166858_ChIP-Seq_MCF-7_Human1.63619033
42FUS_26573619_Chip-Seq_HEK293_Human1.61970697
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61615160
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.57958994
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.54917630
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53476364
47BCAT_22108803_ChIP-Seq_LS180_Human1.52641869
48TAF15_26573619_Chip-Seq_HEK293_Human1.51740738
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.51616192
50NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.50248082
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48670795
52* SOX2_19829295_ChIP-Seq_ESCs_Human1.48007370
53* NANOG_19829295_ChIP-Seq_ESCs_Human1.48007370
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.47934921
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46281376
56BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.45209249
57TP53_22573176_ChIP-Seq_HFKS_Human1.44914318
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.44084183
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43767704
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.43294286
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43294286
62EWS_26573619_Chip-Seq_HEK293_Human1.42030709
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.39977167
64GATA4_25053715_ChIP-Seq_YYC3_Human1.38437211
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38368502
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.36068952
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35275146
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33622744
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33385772
70AR_20517297_ChIP-Seq_VCAP_Human1.32949828
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.32056678
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.30303658
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29809215
74TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29673370
75REST_21632747_ChIP-Seq_MESCs_Mouse1.29126233
76GATA1_22025678_ChIP-Seq_K562_Human1.28136729
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27651499
78STAT3_23295773_ChIP-Seq_U87_Human1.27146306
79TCF4_22108803_ChIP-Seq_LS180_Human1.27042419
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26057697
81MYC_18940864_ChIP-ChIP_HL60_Human1.25843650
82AR_25329375_ChIP-Seq_VCAP_Human1.25199118
83AR_21572438_ChIP-Seq_LNCaP_Human1.23537192
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23154126
85TRIM28_21343339_ChIP-Seq_HEK293_Human1.22052075
86SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21905538
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.21843560
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21571593
89HOXB7_26014856_ChIP-Seq_BT474_Human1.20171753
90LXR_22292898_ChIP-Seq_THP-1_Human1.19342709
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18809103
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18398043
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18398043
94MYC_19829295_ChIP-Seq_ESCs_Human1.18206728
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16782122
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16325421
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16254018
98TCF4_23295773_ChIP-Seq_U87_Human1.16208832
99RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15824345
100CBP_20019798_ChIP-Seq_JUKART_Human1.15170609
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15170609
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15051747
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14221745
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14012671
105NCOR_22424771_ChIP-Seq_293T_Human1.13687901
106RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13583407
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.13507186
108* RACK7_27058665_Chip-Seq_MCF-7_Human1.13263833
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12359932
110SMAD4_21741376_ChIP-Seq_EPCs_Human1.11679400
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11310011
112RNF2_27304074_Chip-Seq_NSC_Mouse1.10835565
113ERA_21632823_ChIP-Seq_H3396_Human1.08730628
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08449749
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.08397128
116FOXH1_21741376_ChIP-Seq_EPCs_Human1.08367623
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07736476
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.07715423
119HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07708590
120SMAD3_21741376_ChIP-Seq_EPCs_Human1.07666655
121FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07597420
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06589607
123* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06328220
124GATA6_25053715_ChIP-Seq_YYC3_Human1.06108295
125ZNF263_19887448_ChIP-Seq_K562_Human1.06063382
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05855318
127SMAD4_21799915_ChIP-Seq_A2780_Human1.05829948
128NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05006460
129RUNX2_22187159_ChIP-Seq_PCA_Human1.04334979
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.03952715
131NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03863085
132IRF1_19129219_ChIP-ChIP_H3396_Human1.02967633
133SRF_21415370_ChIP-Seq_HL-1_Mouse1.02761779
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.01857619
135* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01664152
136TAF2_19829295_ChIP-Seq_ESCs_Human1.01220648
137STAT3_18555785_Chip-Seq_ESCs_Mouse1.01181977
138* HNF4A_19822575_ChIP-Seq_HepG2_Human0.99240877
139SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98243196
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97979650
141CLOCK_20551151_ChIP-Seq_293T_Human0.96577161
142TP63_22573176_ChIP-Seq_HFKS_Human0.94545310
143SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89963119
144IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88687989
145* GATA3_24758297_ChIP-Seq_MCF-7_Human0.87821280
146FOXA2_19822575_ChIP-Seq_HepG2_Human0.86653306
147SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86410591
148SOX2_20726797_ChIP-Seq_SW620_Human0.85568367
149NANOG_18692474_ChIP-Seq_MESCs_Mouse0.85500355
150BCOR_27268052_Chip-Seq_Bcells_Human0.84823236
151OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83491275
152CSB_26484114_Chip-Seq_FIBROBLAST_Human0.83488654
153ERG_21242973_ChIP-ChIP_JURKAT_Human0.83220634
154CEBPB_22108803_ChIP-Seq_LS180_Human0.82274054
155TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81610681
156P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.81487778
157KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80557501
158* ATF3_27146783_Chip-Seq_COLON_Human0.80011394
159RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78595063
160YY1_22570637_ChIP-Seq_MALME-3M_Human0.78363881
161KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77270258
162RUNX1_27514584_Chip-Seq_MCF-7_Human0.76594940
163* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75211278
164ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74869644
165P68_20966046_ChIP-Seq_HELA_Human0.73905231
166* SA1_27219007_Chip-Seq_Bcells_Human0.73700669
167CTCF_21964334_Chip-Seq_Bcells_Human0.73056222
168CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72429588
169SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.72314377
170ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72039588
171NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.71275179
172NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.70406482
173AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70237019
174POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.69503944
175TP53_20018659_ChIP-ChIP_R1E_Mouse0.69018553
176KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.68337423
177TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.67018528
178SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66965022
179* CTCF_27219007_Chip-Seq_Bcells_Human0.66937951
180SA1_27219007_Chip-Seq_ERYTHROID_Human0.66740990
181CTCF_20526341_ChIP-Seq_ESCs_Human0.65943651
182STAT6_21828071_ChIP-Seq_BEAS2B_Human0.65094375
183TP63_23658742_ChIP-Seq_EP156T_Human0.64291235
184NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.63794763
185* NANOG_20526341_ChIP-Seq_ESCs_Human0.63408815
186PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62998136
187* ESET_19884257_ChIP-Seq_ESCs_Mouse0.62786066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.33833544
2MP0002139_abnormal_hepatobiliary_system5.99171253
3MP0005085_abnormal_gallbladder_physiolo4.53335378
4MP0002796_impaired_skin_barrier4.25986864
5MP0005365_abnormal_bile_salt4.25793131
6MP0008875_abnormal_xenobiotic_pharmacok4.09595449
7MP0002254_reproductive_system_inflammat3.87142692
8MP0010234_abnormal_vibrissa_follicle3.41965648
9MP0005451_abnormal_body_composition3.20935217
10MP0003122_maternal_imprinting3.20157607
11MP0003252_abnormal_bile_duct2.91176381
12MP0003806_abnormal_nucleotide_metabolis2.88867213
13MP0003011_delayed_dark_adaptation2.80424713
14MP0004019_abnormal_vitamin_homeostasis2.65000643
15MP0004381_abnormal_hair_follicle2.53918017
16MP0005501_abnormal_skin_physiology2.50282652
17MP0003191_abnormal_cellular_cholesterol2.46394353
18MP0008877_abnormal_DNA_methylation2.42824498
19MP0010329_abnormal_lipoprotein_level2.41341773
20MP0006292_abnormal_olfactory_placode2.39561396
21MP0003705_abnormal_hypodermis_morpholog2.37408224
22MP0005551_abnormal_eye_electrophysiolog2.36001966
23MP0005332_abnormal_amino_acid2.28033479
24MP0003195_calcinosis2.25213403
25MP0003941_abnormal_skin_development2.21032191
26MP0009840_abnormal_foam_cell2.17118466
27MP0005084_abnormal_gallbladder_morpholo2.12834755
28MP0005275_abnormal_skin_tensile2.05972341
29MP0001666_abnormal_nutrient_absorption2.04963562
30MP0002098_abnormal_vibrissa_morphology2.02764532
31MP0005646_abnormal_pituitary_gland1.96267274
32MP0004264_abnormal_extraembryonic_tissu1.86664620
33MP0001216_abnormal_epidermal_layer1.77384083
34MP0003121_genomic_imprinting1.72994961
35MP0002938_white_spotting1.66026586
36MP0004142_abnormal_muscle_tone1.62558878
37MP0008872_abnormal_physiological_respon1.62363268
38MP0002060_abnormal_skin_morphology1.61423883
39MP0010678_abnormal_skin_adnexa1.60432161
40MP0009046_muscle_twitch1.60096705
41MP0005167_abnormal_blood-brain_barrier1.57459499
42MP0002102_abnormal_ear_morphology1.55105781
43MP0000647_abnormal_sebaceous_gland1.52624402
44MP0000609_abnormal_liver_physiology1.51788811
45MP0000377_abnormal_hair_follicle1.49366842
46MP0005083_abnormal_biliary_tract1.48887836
47MP0000383_abnormal_hair_follicle1.45117236
48MP0005410_abnormal_fertilization1.44168309
49MP0001968_abnormal_touch/_nociception1.43709927
50MP0004133_heterotaxia1.42923599
51MP0004885_abnormal_endolymph1.42808742
52MP0002138_abnormal_hepatobiliary_system1.41971863
53MP0003453_abnormal_keratinocyte_physiol1.41941406
54MP0009643_abnormal_urine_homeostasis1.39505480
55MP0002118_abnormal_lipid_homeostasis1.39196361
56MP0005319_abnormal_enzyme/_coenzyme1.38749091
57MP0005645_abnormal_hypothalamus_physiol1.35944696
58MP0003787_abnormal_imprinting1.33523316
59MP0010771_integument_phenotype1.32264306
60MP0003136_yellow_coat_color1.31288209
61MP0006072_abnormal_retinal_apoptosis1.30197728
62MP0001529_abnormal_vocalization1.29799920
63MP0002909_abnormal_adrenal_gland1.26248461
64MP0003283_abnormal_digestive_organ1.25592015
65MP0002638_abnormal_pupillary_reflex1.22913602
66MP0005253_abnormal_eye_physiology1.22490702
67MP0009745_abnormal_behavioral_response1.21227753
68MP0001986_abnormal_taste_sensitivity1.21211841
69MP0002160_abnormal_reproductive_system1.19391442
70MP0003646_muscle_fatigue1.14847735
71MP0004043_abnormal_pH_regulation1.14634454
72MP0000579_abnormal_nail_morphology1.14145749
73MP0003186_abnormal_redox_activity1.13606245
74MP0005389_reproductive_system_phenotype1.13183435
75MP0002272_abnormal_nervous_system1.13168478
76MP0005379_endocrine/exocrine_gland_phen1.12746876
77MP0001501_abnormal_sleep_pattern1.11703607
78MP0002837_dystrophic_cardiac_calcinosis1.11500905
79MP0001984_abnormal_olfaction1.11015245
80MP0005075_abnormal_melanosome_morpholog1.10482100
81MP0004947_skin_inflammation1.09915239
82MP0000427_abnormal_hair_cycle1.09643431
83MP0005377_hearing/vestibular/ear_phenot1.08679049
84MP0003878_abnormal_ear_physiology1.08679049
85MP0000372_irregular_coat_pigmentation1.08337533
86MP0002557_abnormal_social/conspecific_i1.08284886
87MP0000639_abnormal_adrenal_gland1.08042737
88MP0009780_abnormal_chondrocyte_physiolo1.06243387
89MP0000631_abnormal_neuroendocrine_gland1.05610039
90MP0002736_abnormal_nociception_after1.05453285
91MP0001486_abnormal_startle_reflex1.03308665
92MP0000467_abnormal_esophagus_morphology1.02748569
93MP0005636_abnormal_mineral_homeostasis1.01563614
94MP0004782_abnormal_surfactant_physiolog1.00274986
95MP0002234_abnormal_pharynx_morphology1.00128364
96MP0004742_abnormal_vestibular_system0.99639690
97MP0004147_increased_porphyrin_level0.98183373
98MP0005584_abnormal_enzyme/coenzyme_acti0.95430823
99MP0001324_abnormal_eye_pigmentation0.94211115
100MP0000569_abnormal_digit_pigmentation0.94022342
101MP0003698_abnormal_male_reproductive0.93361814
102MP0003880_abnormal_central_pattern0.92809663
103MP0006276_abnormal_autonomic_nervous0.92028105
104MP0005195_abnormal_posterior_eye0.91041068
105MP0001764_abnormal_homeostasis0.90637992
106MP0009931_abnormal_skin_appearance0.90370113
107MP0002572_abnormal_emotion/affect_behav0.90266279
108MP0001293_anophthalmia0.89507702
109MP0009053_abnormal_anal_canal0.89467017
110MP0001191_abnormal_skin_condition0.88810819
111MP0002064_seizures0.87832023
112MP0003567_abnormal_fetal_cardiomyocyte0.84259249
113MP0002229_neurodegeneration0.83062157
114MP0000367_abnormal_coat/_hair0.81993401
115MP0001485_abnormal_pinna_reflex0.81086167
116MP0002282_abnormal_trachea_morphology0.81072122
117MP0001756_abnormal_urination0.80386978
118MP0002249_abnormal_larynx_morphology0.79296673
119MP0002136_abnormal_kidney_physiology0.79231137
120MP0001905_abnormal_dopamine_level0.78437215
121MP0001919_abnormal_reproductive_system0.78210669
122MP0000762_abnormal_tongue_morphology0.78155775
123MP0001929_abnormal_gametogenesis0.76701627
124MP0003718_maternal_effect0.76691449
125MP0002928_abnormal_bile_duct0.75403391
126MP0005386_behavior/neurological_phenoty0.74920076
127MP0004924_abnormal_behavior0.74920076
128MP0005248_abnormal_Harderian_gland0.74752750
129MP0001346_abnormal_lacrimal_gland0.74195302
130MP0003868_abnormal_feces_composition0.73486244
131MP0001765_abnormal_ion_homeostasis0.73241290
132MP0001243_abnormal_dermal_layer0.72829121
133MP0008995_early_reproductive_senescence0.71586218
134MP0010368_abnormal_lymphatic_system0.71550878
135MP0006035_abnormal_mitochondrial_morpho0.71510910
136MP0001270_distended_abdomen0.71299305
137MP0005220_abnormal_exocrine_pancreas0.71018480
138MP0000598_abnormal_liver_morphology0.69336406
139MP0008961_abnormal_basal_metabolism0.69232552
140MP0002163_abnormal_gland_morphology0.68873848
141MP0000653_abnormal_sex_gland0.68299824
142MP0005448_abnormal_energy_balance0.67842765
143MP0003953_abnormal_hormone_level0.67245267
144MP0005647_abnormal_sex_gland0.66837457
145MP0002332_abnormal_exercise_endurance0.66358010
146MP0010352_gastrointestinal_tract_polyps0.66261311
147MP0009764_decreased_sensitivity_to0.65038459
148MP0005499_abnormal_olfactory_system0.63262301
149MP0005394_taste/olfaction_phenotype0.63262301
150MP0002132_abnormal_respiratory_system0.62240211
151MP0005266_abnormal_metabolism0.62042948
152MP0003938_abnormal_ear_development0.60898939
153MP0009765_abnormal_xenobiotic_induced0.59090285
154MP0005023_abnormal_wound_healing0.59081924
155MP0004185_abnormal_adipocyte_glucose0.57790484
156MP0009763_increased_sensitivity_to0.55785264
157MP0004858_abnormal_nervous_system0.54571830
158MP0005670_abnormal_white_adipose0.53118753
159MP0005408_hypopigmentation0.52206579
160MP0005376_homeostasis/metabolism_phenot0.52169350
161MP0003890_abnormal_embryonic-extraembry0.50928735
162MP0009379_abnormal_foot_pigmentation0.50159919
163MP0005666_abnormal_adipose_tissue0.49772785
164MP0006036_abnormal_mitochondrial_physio0.49677571
165MP0003638_abnormal_response/metabolism_0.48875771
166MP0009642_abnormal_blood_homeostasis0.48862265
167MP0002092_abnormal_eye_morphology0.48257535
168MP0002876_abnormal_thyroid_physiology0.46038189
169MP0003566_abnormal_cell_adhesion0.45792405
170MP0003656_abnormal_erythrocyte_physiolo0.44270230
171MP0000566_synostosis0.43916322
172MP0008469_abnormal_protein_level0.43213342
173MP0005395_other_phenotype0.43190904
174MP0003315_abnormal_perineum_morphology0.41486127

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.62119204
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.46219049
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.23626161
4Xanthomatosis (HP:0000991)5.17151361
5Deep venous thrombosis (HP:0002625)4.97845432
6Hyperglycinuria (HP:0003108)4.71567989
7Hypobetalipoproteinemia (HP:0003563)4.46579613
8Prolonged partial thromboplastin time (HP:0003645)4.27974119
9Hypochromic microcytic anemia (HP:0004840)4.25592814
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.23013032
11Abnormality of glycine metabolism (HP:0010895)4.12473803
12Abnormality of serine family amino acid metabolism (HP:0010894)4.12473803
13Gout (HP:0001997)3.83421771
14Hyperammonemia (HP:0001987)3.82450390
15Hyperlipoproteinemia (HP:0010980)3.71666089
16Malnutrition (HP:0004395)3.71128951
17Hyperglycinemia (HP:0002154)3.67356824
18Pancreatic cysts (HP:0001737)3.66416264
19Ketosis (HP:0001946)3.64874289
20Abnormality of aspartate family amino acid metabolism (HP:0010899)3.54741671
21Type II lissencephaly (HP:0007260)3.53705794
22Hypolipoproteinemia (HP:0010981)3.49759429
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.44834336
24Congenital stationary night blindness (HP:0007642)3.38177052
25Congenital ichthyosiform erythroderma (HP:0007431)3.33644325
26Hypotrichosis (HP:0001006)3.30652610
27Molar tooth sign on MRI (HP:0002419)3.27824455
28Abnormality of midbrain morphology (HP:0002418)3.27824455
29Hypothermia (HP:0002045)3.27114709
30True hermaphroditism (HP:0010459)3.24690120
31Complement deficiency (HP:0004431)3.21747418
32Hypoalphalipoproteinemia (HP:0003233)3.20825581
33Joint hemorrhage (HP:0005261)3.20801096
34Epidermoid cyst (HP:0200040)3.16337860
35Nephronophthisis (HP:0000090)3.15265178
36Abnormality of the intrinsic pathway (HP:0010989)3.12804434
37Abnormality of the renal cortex (HP:0011035)3.11722564
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.07748300
39Pancreatic fibrosis (HP:0100732)3.04964467
40Abnormality of purine metabolism (HP:0004352)3.00853654
41Fat malabsorption (HP:0002630)2.98492826
42Abnormality of nucleobase metabolism (HP:0010932)2.91618207
43Abnormality of methionine metabolism (HP:0010901)2.88763781
44Abnormal cartilage morphology (HP:0002763)2.87086523
45Delayed CNS myelination (HP:0002188)2.86796033
46Ketoacidosis (HP:0001993)2.83790039
47Abnormality of fatty-acid metabolism (HP:0004359)2.81646862
48Increased IgE level (HP:0003212)2.80845346
49Vascular calcification (HP:0004934)2.78548838
50Abnormality of complement system (HP:0005339)2.74984254
51Rickets (HP:0002748)2.73188601
52Abnormality of pyrimidine metabolism (HP:0004353)2.73147312
53Abnormality of the renal medulla (HP:0100957)2.72404672
54Lissencephaly (HP:0001339)2.68634634
55Right ventricular cardiomyopathy (HP:0011663)2.67103166
56Attenuation of retinal blood vessels (HP:0007843)2.65296467
57Abnormality of the common coagulation pathway (HP:0010990)2.63458364
58Renal cortical cysts (HP:0000803)2.63375535
59Hypercholesterolemia (HP:0003124)2.61599677
60Multiple enchondromatosis (HP:0005701)2.60354579
61Hepatoblastoma (HP:0002884)2.60101062
62Metabolic acidosis (HP:0001942)2.59543810
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.59029754
64Erythroderma (HP:0001019)2.58050988
65Hypochromic anemia (HP:0001931)2.54778447
66Abolished electroretinogram (ERG) (HP:0000550)2.53942669
67Abnormal drinking behavior (HP:0030082)2.53845711
68Polydipsia (HP:0001959)2.53845711
69Abnormality of nail color (HP:0100643)2.51794851
70Abnormality of alanine metabolism (HP:0010916)2.49894430
71Hyperalaninemia (HP:0003348)2.49894430
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49894430
73Hyperuricemia (HP:0002149)2.49239694
74Increased purine levels (HP:0004368)2.49239694
75Tubular atrophy (HP:0000092)2.42855557
76Abnormal biliary tract physiology (HP:0012439)2.42106905
77Bile duct proliferation (HP:0001408)2.42106905
78Cardiovascular calcification (HP:0011915)2.40577561
79Parakeratosis (HP:0001036)2.40445299
80Abnormality of dicarboxylic acid metabolism (HP:0010995)2.40400993
81Dicarboxylic aciduria (HP:0003215)2.40400993
82Chronic hepatic failure (HP:0100626)2.39382171
83Pendular nystagmus (HP:0012043)2.39226316
84Hyperbilirubinemia (HP:0002904)2.38605411
85Abnormal hemoglobin (HP:0011902)2.37162269
86Hypoglycemic coma (HP:0001325)2.36343860
87Cystic liver disease (HP:0006706)2.34779925
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33905375
89Decreased central vision (HP:0007663)2.33835834
90Medial flaring of the eyebrow (HP:0010747)2.33320930
91Conjugated hyperbilirubinemia (HP:0002908)2.32954631
92Proximal tubulopathy (HP:0000114)2.32729979
93Arthropathy (HP:0003040)2.32204742
94Woolly hair (HP:0002224)2.27443981
95Bilateral microphthalmos (HP:0007633)2.26936715
96Abnormal urine output (HP:0012590)2.26688454
97Irritability (HP:0000737)2.26519955
98Alkalosis (HP:0001948)2.25405685
99Spontaneous abortion (HP:0005268)2.22953597
100Broad alveolar ridges (HP:0000187)2.22470280
101Increased corneal curvature (HP:0100692)2.20888418
102Keratoconus (HP:0000563)2.20888418
103Lethargy (HP:0001254)2.20166104
104Sparse eyelashes (HP:0000653)2.19080779
105Cerebellar dysplasia (HP:0007033)2.18121897
106Abnormality of the Achilles tendon (HP:0005109)2.17981358
107Hyperinsulinemic hypoglycemia (HP:0000825)2.17829183
108Supernumerary spleens (HP:0009799)2.17415338
109Steatorrhea (HP:0002570)2.16997843
110Dehydration (HP:0001944)2.16956852
111Abnormality of serum amino acid levels (HP:0003112)2.16290645
112Onycholysis (HP:0001806)2.15486498
113Hyperactive renin-angiotensin system (HP:0000841)2.14739961
114Skin nodule (HP:0200036)2.13051613
115Abnormal enzyme/coenzyme activity (HP:0012379)2.12753985
116Polyuria (HP:0000103)2.11116994
117Abnormality of proline metabolism (HP:0010907)2.10061463
118Hydroxyprolinuria (HP:0003080)2.10061463
119Acute necrotizing encephalopathy (HP:0006965)2.09744236
120Sclerocornea (HP:0000647)2.09443915
121Erythema (HP:0010783)2.08777159
122Vomiting (HP:0002013)2.08209433
123Amyloidosis (HP:0011034)2.07913744
124Abnormal rod and cone electroretinograms (HP:0008323)2.07303606
125Aplasia/Hypoplasia of the tibia (HP:0005772)2.07091022
126Abnormality of the vitreous humor (HP:0004327)2.06566353
127Hepatocellular carcinoma (HP:0001402)2.06448297
128Potter facies (HP:0002009)2.05872774
129Facial shape deformation (HP:0011334)2.05872774
130Acute encephalopathy (HP:0006846)2.05813641
131Mitochondrial inheritance (HP:0001427)2.05736685
132Pancreatic islet-cell hyperplasia (HP:0004510)2.05167324
133Fair hair (HP:0002286)2.05068456
134Enlarged kidneys (HP:0000105)2.02611656
135Increased CSF lactate (HP:0002490)1.98630462
136Plantar hyperkeratosis (HP:0007556)1.97049513
137Abnormality of alkaline phosphatase activity (HP:0004379)1.95159336
138Neonatal onset (HP:0003623)1.94584120
139Concave nail (HP:0001598)1.93636446
140Abnormality of urine glucose concentration (HP:0011016)1.93514549
141Glycosuria (HP:0003076)1.93514549
142Abnormality of secondary sexual hair (HP:0009888)1.93408181
143Abnormality of the axillary hair (HP:0100134)1.93408181
144Hypophosphatemic rickets (HP:0004912)1.92868376
145Generalized aminoaciduria (HP:0002909)1.92863785
146Villous atrophy (HP:0011473)1.92428397
147Abnormality of small intestinal villus morphology (HP:0011472)1.92428397
148Large for gestational age (HP:0001520)1.92361397
149Severe muscular hypotonia (HP:0006829)1.91965963
150Optic disc pallor (HP:0000543)1.91819454
151Short tibia (HP:0005736)1.91198559
152Myocardial infarction (HP:0001658)1.89879555
153Palmoplantar hyperkeratosis (HP:0000972)1.89751371
154Male pseudohermaphroditism (HP:0000037)1.86729550
155Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86503649
156Inability to walk (HP:0002540)1.85565435
157Hypomagnesemia (HP:0002917)1.85319725
158Abnormality of renal excretion (HP:0011036)1.84864956
159Hepatic necrosis (HP:0002605)1.83086690
160Congenital, generalized hypertrichosis (HP:0004540)1.82710475
161Progressive macrocephaly (HP:0004481)1.82605609
162Abnormality of the pons (HP:0007361)1.81937290
163Retinal dysplasia (HP:0007973)1.80206836
164Abnormal mitochondria in muscle tissue (HP:0008316)1.79650274
165Anophthalmia (HP:0000528)1.79495237
166Lipid accumulation in hepatocytes (HP:0006561)1.79200817
167Methylmalonic acidemia (HP:0002912)1.77682447
168Abnormality of the nasal septum (HP:0000419)1.75293885
169Hyperventilation (HP:0002883)1.74919201
170Hypoplasia of the pons (HP:0012110)1.74590862
171Methylmalonic aciduria (HP:0012120)1.67258628
172Mesangial abnormality (HP:0001966)1.66241866
173Postaxial foot polydactyly (HP:0001830)1.65649912
174Hepatocellular necrosis (HP:0001404)1.65145691
175Prominent supraorbital ridges (HP:0000336)1.64722549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.76401499
2CDK124.20831775
3BCKDK3.73575973
4BMPR1B3.47917088
5MST1R3.26433236
6GRK53.16864741
7GRK62.89592404
8GRK12.79672390
9MAP3K32.72758041
10MAP4K22.69110354
11NUAK12.52609189
12ZAK2.48433176
13TLK12.47340402
14TGFBR22.39946965
15MAPKAPK32.32805759
16ACVR1B2.30491615
17FGFR42.25839466
18TXK2.22124937
19STK102.07648447
20WNK41.98159621
21MAP3K21.93257232
22TTK1.85026155
23FGFR21.83904055
24SIK11.83036823
25GRK71.77726310
26CASK1.67664067
27DAPK21.66237466
28MAP2K41.63569135
29ADRBK21.58133863
30LATS11.57942305
31MATK1.57350326
32EPHA21.55871801
33NME11.49383602
34MAPK131.45028619
35MAPK71.40981056
36CSF1R1.40089343
37OXSR11.33475124
38MOS1.32648376
39ERBB41.30808597
40MAP3K41.28190028
41STK38L1.27384548
42EPHB21.27333295
43PIK3CA1.27273334
44WNK31.26859666
45PIK3CG1.23870249
46MST41.23042140
47MAP3K71.18994714
48MAP2K61.18405864
49DYRK21.16997828
50WNK11.16045926
51NTRK31.14364778
52DYRK1B1.08737548
53TYRO31.07412995
54TYK21.03751804
55SIK21.03213191
56PRKCG1.03194177
57AKT31.03144035
58TRIM281.02897745
59LATS21.02346941
60CAMKK21.01747916
61RPS6KB21.01226783
62NTRK21.00884029
63MAPK110.99854738
64MET0.96402896
65PAK30.90455910
66PIM20.89603841
67PLK20.85160504
68MAPK120.85146302
69MAP3K110.83278359
70VRK10.82905489
71ERBB20.82719464
72EPHA40.80583260
73FER0.80267927
74PTK60.79816936
75CSNK1G10.79716385
76PHKG10.79665276
77PHKG20.79665276
78FGFR30.79601154
79LRRK20.79370524
80TIE10.78831550
81PRKCE0.78557876
82MAPKAPK50.77722367
83ABL20.77630525
84NEK20.77062116
85PLK40.76593711
86BRSK20.75919763
87STK160.75502536
88PRKAA20.74641664
89INSRR0.73709573
90TGFBR10.72969648
91CSK0.72104783
92BCR0.71845235
93CSNK1G20.71715586
94MUSK0.71538055
95CAMK40.71536852
96MKNK20.71301098
97MAP2K70.70994429
98MAP3K100.70198278
99PINK10.70190964
100MAPK40.69916359
101MAP2K20.69720244
102ADRBK10.68919340
103CSNK1G30.67741370
104MARK20.66892641
105EIF2AK30.66822992
106PLK30.65210308
107CSNK1A1L0.64799022
108EIF2AK20.63462490
109FLT30.61792701
110MARK10.61366463
111NTRK10.60747262
112JAK20.60351068
113GSK3A0.59680478
114MAPK150.59479496
115TNIK0.59215529
116PRKCQ0.58207970
117BLK0.57963778
118PRKCI0.57601881
119PRKG20.56363880
120FGFR10.56310583
121NME20.55617832
122ERBB30.55214036
123RPS6KA50.53307046
124VRK20.53299283
125RIPK10.52399260
126PRKACA0.51759621
127TAOK10.51668814
128PTK2B0.49209835
129PTK20.49017860
130ITK0.46952994
131CSNK1A10.45540860
132CHUK0.45149567
133CSNK1D0.44836656
134PRKACG0.44136508
135STK380.43257437
136PRKCZ0.43100634
137CAMK2A0.42805908
138BRAF0.42503849
139EIF2AK10.42275866
140CDK70.41973499
141STK30.41236984
142IGF1R0.40594401
143IKBKB0.40452539
144CDK60.38756958
145FRK0.38466672
146PRKG10.37485515
147SGK4940.36400416
148SGK2230.36400416
149MAP2K30.35681464
150TAOK30.35448969
151KIT0.33832480
152PRKCA0.32475757
153AKT20.32398377
154PNCK0.32307135
155TEC0.32178307
156MKNK10.31786583
157CSNK2A10.30763972
158PRKAA10.30623985
159HIPK20.30090370
160PDK40.27951606
161PDK30.27951606
162CSNK1E0.27749264
163MAP3K10.27118949
164AURKA0.25406808
165STK390.25243604
166MAP3K50.24584850
167TAOK20.24084954
168ABL10.23777171
169PRKCD0.23505207
170IRAK30.23186425

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.72959968
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18253486
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81231055
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.74623890
5Tryptophan metabolism_Homo sapiens_hsa003802.67597242
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.64297089
7Arginine biosynthesis_Homo sapiens_hsa002202.59346132
8Nitrogen metabolism_Homo sapiens_hsa009102.57372126
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51547945
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.45156896
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.42250277
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38924825
13Fatty acid degradation_Homo sapiens_hsa000712.28596534
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.24818215
15Chemical carcinogenesis_Homo sapiens_hsa052042.22201592
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.21232836
17Complement and coagulation cascades_Homo sapiens_hsa046102.17864725
18Histidine metabolism_Homo sapiens_hsa003402.15748178
19Butanoate metabolism_Homo sapiens_hsa006502.08273081
20Phototransduction_Homo sapiens_hsa047442.06763053
21Peroxisome_Homo sapiens_hsa041462.02637446
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02007234
23Retinol metabolism_Homo sapiens_hsa008301.84767749
24Caffeine metabolism_Homo sapiens_hsa002321.75933459
25PPAR signaling pathway_Homo sapiens_hsa033201.75066656
26Phenylalanine metabolism_Homo sapiens_hsa003601.72878341
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.71658521
28beta-Alanine metabolism_Homo sapiens_hsa004101.70157027
29Oxidative phosphorylation_Homo sapiens_hsa001901.68929595
30Vitamin B6 metabolism_Homo sapiens_hsa007501.67107605
31Propanoate metabolism_Homo sapiens_hsa006401.65181205
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64236107
33Folate biosynthesis_Homo sapiens_hsa007901.63254327
34Protein export_Homo sapiens_hsa030601.60546345
35Fatty acid elongation_Homo sapiens_hsa000621.60381193
36Fatty acid metabolism_Homo sapiens_hsa012121.56269835
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53986765
38Selenocompound metabolism_Homo sapiens_hsa004501.53198702
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48165189
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.45314159
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43993353
42Bile secretion_Homo sapiens_hsa049761.43356593
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40992416
44Tyrosine metabolism_Homo sapiens_hsa003501.39969979
45RNA polymerase_Homo sapiens_hsa030201.33513500
46Sulfur metabolism_Homo sapiens_hsa009201.33058115
47Vitamin digestion and absorption_Homo sapiens_hsa049771.32923677
48Fat digestion and absorption_Homo sapiens_hsa049751.32600798
49ABC transporters_Homo sapiens_hsa020101.32367789
50Staphylococcus aureus infection_Homo sapiens_hsa051501.31466022
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26123030
52Linoleic acid metabolism_Homo sapiens_hsa005911.22142189
53Sulfur relay system_Homo sapiens_hsa041221.15458054
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14871756
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14441044
56Pyruvate metabolism_Homo sapiens_hsa006201.13345911
57Nicotine addiction_Homo sapiens_hsa050331.13188860
58Parkinsons disease_Homo sapiens_hsa050121.11964297
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10833610
60Starch and sucrose metabolism_Homo sapiens_hsa005001.10657277
61Glutathione metabolism_Homo sapiens_hsa004801.09071911
62Arachidonic acid metabolism_Homo sapiens_hsa005901.08598351
63Biosynthesis of amino acids_Homo sapiens_hsa012301.04487714
64Carbon metabolism_Homo sapiens_hsa012001.03670504
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01247777
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.98579152
67RNA degradation_Homo sapiens_hsa030180.92938540
68Steroid biosynthesis_Homo sapiens_hsa001000.92287123
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89025568
70Arginine and proline metabolism_Homo sapiens_hsa003300.88650417
71Basal transcription factors_Homo sapiens_hsa030220.88468444
72Fanconi anemia pathway_Homo sapiens_hsa034600.84477169
73Glycerolipid metabolism_Homo sapiens_hsa005610.84465780
74Fructose and mannose metabolism_Homo sapiens_hsa000510.84294604
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82470921
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.78067624
77Proteasome_Homo sapiens_hsa030500.77734909
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73609592
79Lysine degradation_Homo sapiens_hsa003100.70629751
80Huntingtons disease_Homo sapiens_hsa050160.70041311
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67934766
82Homologous recombination_Homo sapiens_hsa034400.67489812
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65050376
84Taste transduction_Homo sapiens_hsa047420.64713746
85Pentose phosphate pathway_Homo sapiens_hsa000300.62812877
86Olfactory transduction_Homo sapiens_hsa047400.62426299
87Alzheimers disease_Homo sapiens_hsa050100.61668417
88Galactose metabolism_Homo sapiens_hsa000520.58911348
89One carbon pool by folate_Homo sapiens_hsa006700.57471343
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.57391073
91Metabolic pathways_Homo sapiens_hsa011000.54958729
92Cardiac muscle contraction_Homo sapiens_hsa042600.51584758
93GABAergic synapse_Homo sapiens_hsa047270.46160149
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46135667
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.45805300
96Glutamatergic synapse_Homo sapiens_hsa047240.40605658
97Purine metabolism_Homo sapiens_hsa002300.40343678
98Serotonergic synapse_Homo sapiens_hsa047260.40336611
99Asthma_Homo sapiens_hsa053100.38859156
100Type I diabetes mellitus_Homo sapiens_hsa049400.38815545
101Collecting duct acid secretion_Homo sapiens_hsa049660.37084416
102Insulin secretion_Homo sapiens_hsa049110.37001796
103Sphingolipid metabolism_Homo sapiens_hsa006000.35799661
104Morphine addiction_Homo sapiens_hsa050320.35590948
105Ribosome_Homo sapiens_hsa030100.33880038
106Ether lipid metabolism_Homo sapiens_hsa005650.32499179
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32322868
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29772082
109Fatty acid biosynthesis_Homo sapiens_hsa000610.29500495
110Mineral absorption_Homo sapiens_hsa049780.22397641
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19389544
112Renin-angiotensin system_Homo sapiens_hsa046140.17849397
113Ovarian steroidogenesis_Homo sapiens_hsa049130.17583710
114Other glycan degradation_Homo sapiens_hsa005110.17307919
115Bladder cancer_Homo sapiens_hsa052190.15623829
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.14647713
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13659707
118Protein digestion and absorption_Homo sapiens_hsa049740.13485204
119Insulin resistance_Homo sapiens_hsa049310.12962448
120Basal cell carcinoma_Homo sapiens_hsa052170.04184945
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.02127910
122Thyroid cancer_Homo sapiens_hsa05216-3.6465377
123Inositol phosphate metabolism_Homo sapiens_hsa00562-0.1750650
124Hedgehog signaling pathway_Homo sapiens_hsa04340-0.1720413
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1563730
126Tight junction_Homo sapiens_hsa04530-0.1452553
127Prion diseases_Homo sapiens_hsa05020-0.1262629
128Regulation of autophagy_Homo sapiens_hsa04140-0.0900842
129AMPK signaling pathway_Homo sapiens_hsa04152-0.0278754
130Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0214479
131Hepatitis C_Homo sapiens_hsa05160-0.0093183

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