ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tetrapyrrole biosynthetic process (GO:0033014)	9.62208887
2	erythrocyte maturation (GO:0043249)	9.22619293
3	porphyrin-containing compound metabolic process (GO:0006778)	9.15940192
4	heme biosynthetic process (GO:0006783)	8.82844158
5	hemoglobin metabolic process (GO:0020027)	7.97027602
6	erythrocyte development (GO:0048821)	7.80115094
7	heme metabolic process (GO:0042168)	7.72365864
8	myeloid cell development (GO:0061515)	5.82262649
9	tetrapyrrole metabolic process (GO:0033013)	5.77902557
10	regulation of response to osmotic stress (GO:0047484)	5.33701959
11	response to methylmercury (GO:0051597)	4.73848209
12	granulocyte differentiation (GO:0030851)	4.54414073
13	megakaryocyte development (GO:0035855)	4.41980835
14	one-carbon compound transport (GO:0019755)	4.32156781
15	modulation by virus of host process (GO:0019054)	4.24227091
16	innate immune response in mucosa (GO:0002227)	4.16044144
17	antibacterial humoral response (GO:0019731)	4.10454248
18	protein-cofactor linkage (GO:0018065)	4.09953359
19	response to insecticide (GO:0017085)	4.06944230
20	platelet formation (GO:0030220)	4.04984068
21	glycine transport (GO:0015816)	3.98923640
22	definitive hemopoiesis (GO:0060216)	3.90175901
23	embryonic hemopoiesis (GO:0035162)	3.87570576
24	erythrocyte differentiation (GO:0030218)	3.86301231
25	pigment biosynthetic process (GO:0046148)	3.81496058
26	response to lead ion (GO:0010288)	3.77220523
27	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.71079669
28	antimicrobial humoral response (GO:0019730)	3.66762469
29	bicarbonate transport (GO:0015701)	3.66305844
30	negative regulation of erythrocyte differentiation (GO:0045647)	3.66205601
31	negative regulation of viral entry into host cell (GO:0046597)	3.64482687
32	iron ion import (GO:0097286)	3.59191962
33	disruption of cells of other organism (GO:0044364)	3.59100062
34	killing of cells of other organism (GO:0031640)	3.59100062
35	pigment metabolic process (GO:0042440)	3.47695953
36	S-adenosylmethionine metabolic process (GO:0046500)	3.39097738
37	protein neddylation (GO:0045116)	3.38886798
38	regulation of erythrocyte differentiation (GO:0045646)	3.37861133
39	positive regulation of granulocyte differentiation (GO:0030854)	3.37488332
40	mucosal immune response (GO:0002385)	3.35685133
41	positive regulation of erythrocyte differentiation (GO:0045648)	3.32738245
42	hematopoietic stem cell differentiation (GO:0060218)	3.20741540
43	hydrogen peroxide catabolic process (GO:0042744)	3.19841727
44	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.16650975
45	deoxyribose phosphate biosynthetic process (GO:0046385)	3.16650975
46	modulation by symbiont of host cellular process (GO:0044068)	3.07638923
47	homocysteine metabolic process (GO:0050667)	3.06811084
48	organ or tissue specific immune response (GO:0002251)	3.00658420
49	positive regulation of megakaryocyte differentiation (GO:0045654)	2.99402219
50	defense response to fungus (GO:0050832)	2.98477966
51	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.92432560
52	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.86036059
53	poly(A)+ mRNA export from nucleus (GO:0016973)	2.83723606
54	neutrophil activation involved in immune response (GO:0002283)	2.83104084
55	ATP synthesis coupled proton transport (GO:0015986)	2.82594805
56	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.82594805
57	response to arsenic-containing substance (GO:0046685)	2.80780101
58	preassembly of GPI anchor in ER membrane (GO:0016254)	2.78359470
59	DNA topological change (GO:0006265)	2.74756398
60	ribosomal small subunit biogenesis (GO:0042274)	2.68012938
61	regulation of viral entry into host cell (GO:0046596)	2.66112747
62	viral transcription (GO:0019083)	2.63185885
63	cofactor biosynthetic process (GO:0051188)	2.62194878
64	regulation of histone H3-K9 methylation (GO:0051570)	2.62076900
65	cellular protein catabolic process (GO:0044257)	2.60948846
66	ribosomal small subunit assembly (GO:0000028)	2.60801155
67	cellular response to arsenic-containing substance (GO:0071243)	2.60635165
68	translational termination (GO:0006415)	2.58929630
69	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.58780115
70	folic acid metabolic process (GO:0046655)	2.56017748
71	DNA replication checkpoint (GO:0000076)	2.54414960
72	cysteine metabolic process (GO:0006534)	2.49322732
73	autophagic vacuole fusion (GO:0000046)	2.45233500
74	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.44673431
75	purine-containing compound salvage (GO:0043101)	2.44181500
76	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	2.40309115
77	regulation of histone H3-K4 methylation (GO:0051569)	2.39716786
78	deoxyribonucleotide biosynthetic process (GO:0009263)	2.36866147
79	positive regulation of response to oxidative stress (GO:1902884)	2.36334085
80	positive regulation of cellular response to oxidative stress (GO:1900409)	2.36334085
81	organelle membrane fusion (GO:0090174)	2.33456448
82	hemopoiesis (GO:0030097)	2.33031138
83	proline biosynthetic process (GO:0006561)	2.31451452
84	iron ion homeostasis (GO:0055072)	2.28476684
85	translational elongation (GO:0006414)	2.25351190
86	kinetochore organization (GO:0051383)	2.22454396
87	hydrogen peroxide metabolic process (GO:0042743)	2.21130890
88	regulation of megakaryocyte differentiation (GO:0045652)	2.20231461
89	pyrimidine nucleotide catabolic process (GO:0006244)	2.19433965
90	viral life cycle (GO:0019058)	2.19413027
91	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	2.18753007
92	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	2.18753007
93	regulation of translational fidelity (GO:0006450)	2.18633202
94	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.18580447
95	very-low-density lipoprotein particle assembly (GO:0034379)	2.18004783
96	protoporphyrinogen IX metabolic process (GO:0046501)	15.1486688
97	oxygen transport (GO:0015671)	14.7541861
98	gas transport (GO:0015669)	13.4067883
99	protoporphyrinogen IX biosynthetic process (GO:0006782)	12.8991598
100	porphyrin-containing compound biosynthetic process (GO:0006779)	10.4830223

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	6.90705505
2	E2F7_22180533_ChIP-Seq_HELA_Human	6.00249029
3	GATA1_19941826_ChIP-Seq_K562_Human	5.98757389
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	4.55579879
5	GATA2_19941826_ChIP-Seq_K562_Human	3.67533193
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.38988055
7	SCL_19346495_ChIP-Seq_HPC-7_Human	3.06029896
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.88476720
9	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	2.73195248
10	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.67431633
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.66770504
12	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	2.51758099
13	NCOR1_26117541_ChIP-Seq_K562_Human	2.43831028
14	GATA1_19941827_ChIP-Seq_MEL_Mouse	2.35719537
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.11923650
16	GATA1_22383799_ChIP-Seq_G1ME_Mouse	2.00307005
17	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.98647243
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.92917611
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.90411617
20	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.88220163
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.86499774
22	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.83588611
23	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.82336367
24	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.78268525
25	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.75739013
26	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.75542808
27	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.66666321
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.66191659
29	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.62372839
30	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.60162949
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.58996212
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.56966298
33	XRN2_22483619_ChIP-Seq_HELA_Human	1.56651599
34	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.54626732
35	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.48116460
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.47285420
37	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.43959901
38	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.43572671
39	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.42941884
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.39405808
41	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.36000856
42	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.31533362
43	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.29667278
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.29482965
45	DCP1A_22483619_ChIP-Seq_HELA_Human	1.29381664
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.29253380
47	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.28720766
48	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.27442730
49	ZNF263_19887448_ChIP-Seq_K562_Human	1.26134762
50	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.25435300
51	VDR_22108803_ChIP-Seq_LS180_Human	1.23849210
52	TFEB_21752829_ChIP-Seq_HELA_Human	1.21416578
53	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.20272696
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.19741618
55	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.19199572
56	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.19145275
57	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.15196193
58	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.14860455
59	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.14208916
60	VDR_21846776_ChIP-Seq_THP-1_Human	1.12452580
61	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.11079988
62	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.08958522
63	MAF_26560356_Chip-Seq_TH1_Human	1.07699978
64	UTX_26944678_Chip-Seq_JUKART_Human	1.07649331
65	MYC_22102868_ChIP-Seq_BL_Human	1.07396361
66	GABP_19822575_ChIP-Seq_HepG2_Human	1.05754559
67	CTCF_21964334_Chip-Seq_Bcells_Human	1.05675630
68	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.04905341
69	SPI1_23127762_ChIP-Seq_K562_Human	1.03162596
70	* BCL6_27268052_Chip-Seq_Bcells_Human	1.02121568
71	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.01487715
72	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.01060538
73	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.99755330
74	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.99532014
75	* BCOR_27268052_Chip-Seq_Bcells_Human	0.98620608
76	KDM5A_27292631_Chip-Seq_BREAST_Human	0.97534082
77	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.97405190
78	ETS1_22383799_ChIP-Seq_G1ME_Mouse	0.96268881
79	CIITA_25753668_ChIP-Seq_RAJI_Human	0.95811589
80	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.94361046
81	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.93951588
82	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.93422742
83	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.92646745
84	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.92224109
85	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.91981763
86	IRF1_19129219_ChIP-ChIP_H3396_Human	0.91592409
87	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.90412267
88	ELK1_19687146_ChIP-ChIP_HELA_Human	0.90379880
89	SPI1_20517297_ChIP-Seq_HL60_Human	0.89178603
90	SPI1_23547873_ChIP-Seq_NB4_Human	0.87707241
91	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.87673306
92	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.87184070
93	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.87057339
94	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.86393483
95	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.85760005
96	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.85525571
97	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.83552889
98	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.82311492
99	* GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.81308416
100	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.81241105

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003656_abnormal_erythrocyte_physiolo	8.72048415
2	MP0005083_abnormal_biliary_tract	4.88683908
3	MP0005397_hematopoietic_system_phenotyp	3.25492789
4	MP0001545_abnormal_hematopoietic_system	3.25492789
5	MP0005636_abnormal_mineral_homeostasis	2.17433976
6	MP0003878_abnormal_ear_physiology	2.14037535
7	MP0005377_hearing/vestibular/ear_phenot	2.14037535
8	MP0005464_abnormal_platelet_physiology	2.12583562
9	MP0003186_abnormal_redox_activity	2.11886016
10	MP0008995_early_reproductive_senescence	2.03471454
11	MP0004147_increased_porphyrin_level	11.2672211
12	MP0009278_abnormal_bone_marrow	1.91973226
13	MP0003303_peritoneal_inflammation	1.91172432
14	MP0000015_abnormal_ear_pigmentation	1.89088061
15	MP0003111_abnormal_nucleus_morphology	1.86430892
16	MP0006036_abnormal_mitochondrial_physio	1.58747601
17	MP0002095_abnormal_skin_pigmentation	1.51058023
18	MP0003879_abnormal_hair_cell	1.48952688
19	MP0008058_abnormal_DNA_repair	1.48655114
20	MP0004145_abnormal_muscle_electrophysio	1.46603030
21	MP0002132_abnormal_respiratory_system	1.42629996
22	MP0004885_abnormal_endolymph	1.32139025
23	MP0002398_abnormal_bone_marrow	1.30994939
24	MP0003786_premature_aging	1.25277120
25	MP0001529_abnormal_vocalization	1.24690730
26	MP0008775_abnormal_heart_ventricle	1.17771907
27	MP0002722_abnormal_immune_system	1.15467372
28	MP0002653_abnormal_ependyma_morphology	1.15221087
29	MP0008872_abnormal_physiological_respon	1.12579202
30	MP0000689_abnormal_spleen_morphology	1.12350614
31	MP0002138_abnormal_hepatobiliary_system	1.09318315
32	MP0010094_abnormal_chromosome_stability	1.03476019
33	MP0004808_abnormal_hematopoietic_stem	1.01245155
34	MP0005075_abnormal_melanosome_morpholog	0.99958045
35	MP0004142_abnormal_muscle_tone	0.94893866
36	MP0002429_abnormal_blood_cell	0.94705307
37	MP0004957_abnormal_blastocyst_morpholog	0.94065201
38	MP0000372_irregular_coat_pigmentation	0.90596101
39	MP0009333_abnormal_splenocyte_physiolog	0.89276356
40	MP0006035_abnormal_mitochondrial_morpho	0.86624357
41	MP0000313_abnormal_cell_death	0.84047445
42	MP0009764_decreased_sensitivity_to	0.83319168
43	MP0006054_spinal_hemorrhage	0.82658661
44	MP0003077_abnormal_cell_cycle	0.81803139
45	MP0009697_abnormal_copulation	0.81495880
46	MP0003806_abnormal_nucleotide_metabolis	0.80091329
47	MP0009931_abnormal_skin_appearance	0.78296726
48	MP0009785_altered_susceptibility_to	0.78164084
49	MP0005646_abnormal_pituitary_gland	0.77485313
50	MP0003693_abnormal_embryo_hatching	0.76901444
51	MP0000703_abnormal_thymus_morphology	0.75568414
52	MP0006276_abnormal_autonomic_nervous	0.75372515
53	MP0008004_abnormal_stomach_pH	0.75310064
54	MP0009765_abnormal_xenobiotic_induced	0.73690344
55	MP0003136_yellow_coat_color	0.70442105
56	MP0000685_abnormal_immune_system	0.69820016
57	MP0005645_abnormal_hypothalamus_physiol	0.68762913
58	MP0000343_altered_response_to	0.68695748
59	MP0005025_abnormal_response_to	0.68586586
60	MP0003718_maternal_effect	0.68497458
61	MP0005171_absent_coat_pigmentation	0.64360124
62	MP0001764_abnormal_homeostasis	0.63014105
63	MP0001986_abnormal_taste_sensitivity	0.62835916
64	MP0000465_gastrointestinal_hemorrhage	0.61889431
65	MP0002019_abnormal_tumor_incidence	0.59948717
66	MP0000609_abnormal_liver_physiology	0.59890674
67	MP0005000_abnormal_immune_tolerance	0.58840813
68	MP0002405_respiratory_system_inflammati	0.58465272
69	MP0003436_decreased_susceptibility_to	0.57126835
70	MP0001188_hyperpigmentation	0.55733953
71	MP0001664_abnormal_digestion	0.55351901
72	MP0000716_abnormal_immune_system	0.55340473
73	MP0001905_abnormal_dopamine_level	0.54967477
74	MP0002396_abnormal_hematopoietic_system	0.54692741
75	MP0010307_abnormal_tumor_latency	0.53945885
76	MP0009643_abnormal_urine_homeostasis	0.53665900
77	MP0005671_abnormal_response_to	0.52517826
78	MP0002420_abnormal_adaptive_immunity	0.52007200
79	MP0005410_abnormal_fertilization	0.50589290
80	MP0004130_abnormal_muscle_cell	0.50514599
81	MP0002210_abnormal_sex_determination	0.50249758
82	MP0002083_premature_death	0.50206055
83	MP0008057_abnormal_DNA_replication	0.50173249
84	MP0001819_abnormal_immune_cell	0.50100557
85	MP0005084_abnormal_gallbladder_morpholo	0.49890052
86	MP0003866_abnormal_defecation	0.49823073
87	MP0003698_abnormal_male_reproductive	0.48498083
88	MP0005220_abnormal_exocrine_pancreas	0.48350232
89	MP0001929_abnormal_gametogenesis	0.47931429
90	MP0000598_abnormal_liver_morphology	0.47705827
91	MP0009763_increased_sensitivity_to	0.46110828
92	MP0005174_abnormal_tail_pigmentation	0.45628823
93	MP0008873_increased_physiological_sensi	0.45528923
94	MP0005451_abnormal_body_composition	0.43478440
95	MP0001727_abnormal_embryo_implantation	0.43361041
96	MP0003172_abnormal_lysosome_physiology	0.43335444
97	MP0003011_delayed_dark_adaptation	0.43066674
98	MP0005501_abnormal_skin_physiology	0.42530482
99	MP0001756_abnormal_urination	0.42408392
100	MP0002723_abnormal_immune_serum	0.40953745

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Poikilocytosis (HP:0004447)	9.72528047
2	Abnormal hemoglobin (HP:0011902)	8.75965143
3	Reticulocytosis (HP:0001923)	7.57694413
4	Hypochromic microcytic anemia (HP:0004840)	7.11713374
5	Microcytic anemia (HP:0001935)	6.21904118
6	Acanthocytosis (HP:0001927)	6.03725397
7	Paralysis (HP:0003470)	5.73093939
8	Abnormality of reticulocytes (HP:0004312)	5.33303707
9	Polycythemia (HP:0001901)	5.11773381
10	Cholelithiasis (HP:0001081)	4.91824919
11	Hypochromic anemia (HP:0001931)	4.85530019
12	Abnormal gallbladder morphology (HP:0012437)	4.46020575
13	Pallor (HP:0000980)	4.41650743
14	Ileus (HP:0002595)	4.14870685
15	Abnormal number of erythroid precursors (HP:0012131)	4.08426753
16	Hyperbilirubinemia (HP:0002904)	3.99803288
17	Prolonged bleeding time (HP:0003010)	3.92750834
18	Abnormality of cells of the erythroid lineage (HP:0012130)	3.80242903
19	Diaphragmatic weakness (HP:0009113)	3.49505979
20	Hypertensive crisis (HP:0100735)	3.45618432
21	Cholecystitis (HP:0001082)	3.31122897
22	Abnormal gallbladder physiology (HP:0012438)	3.31122897
23	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	3.24621718
24	Abnormality of the gallbladder (HP:0005264)	3.24421752
25	Impaired platelet aggregation (HP:0003540)	3.13283544
26	Abnormal platelet function (HP:0011869)	3.13283544
27	Abnormality of iron homeostasis (HP:0011031)	3.08637369
28	Petechiae (HP:0000967)	3.07473067
29	Abnormality of transition element cation homeostasis (HP:0011030)	2.96116330
30	Homocystinuria (HP:0002156)	2.90242558
31	Abnormality of homocysteine metabolism (HP:0010919)	2.90242558
32	Gastrointestinal infarctions (HP:0005244)	2.86607632
33	Albinism (HP:0001022)	2.73150053
34	Hyperthyroidism (HP:0000836)	2.69230207
35	Cutaneous photosensitivity (HP:0000992)	2.68146874
36	Nausea (HP:0002018)	2.67189022
37	Epistaxis (HP:0000421)	2.59580846
38	Insomnia (HP:0100785)	2.59245771
39	Increased serum ferritin (HP:0003281)	2.56117167
40	Acute necrotizing encephalopathy (HP:0006965)	2.51015877
41	Toxemia of pregnancy (HP:0100603)	2.47530838
42	Osteomalacia (HP:0002749)	2.44634907
43	Truncus arteriosus (HP:0001660)	2.41425563
44	Acute encephalopathy (HP:0006846)	2.41126049
45	Cerebral palsy (HP:0100021)	2.30371450
46	Abnormal mitochondria in muscle tissue (HP:0008316)	2.25800803
47	Increased mean platelet volume (HP:0011877)	2.22577585
48	Hypoparathyroidism (HP:0000829)	2.10945118
49	Abnormal platelet volume (HP:0011876)	2.09658962
50	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.08885834
51	Progressive macrocephaly (HP:0004481)	2.01633494
52	Abnormality of the fingertips (HP:0001211)	2.00570878
53	Esophageal neoplasm (HP:0100751)	2.00560167
54	Neoplasm of head and neck (HP:0012288)	2.00560167
55	Abnormality of the heme biosynthetic pathway (HP:0010472)	15.3869393
56	Hyponatremia (HP:0002902)	1.93149225
57	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.89705983
58	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.89705983
59	Increased IgM level (HP:0003496)	1.86392548
60	Nonimmune hydrops fetalis (HP:0001790)	1.86003499
61	Rectal prolapse (HP:0002035)	1.85646463
62	Abnormality of sodium homeostasis (HP:0010931)	1.83756990
63	Menorrhagia (HP:0000132)	1.83186002
64	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.82443661
65	Hepatocellular carcinoma (HP:0001402)	1.76298842
66	3-Methylglutaconic aciduria (HP:0003535)	1.76218349
67	Abnormality of renal resorption (HP:0011038)	1.67622212
68	Seborrheic dermatitis (HP:0001051)	1.65563802
69	Macrocytic anemia (HP:0001972)	1.63060783
70	Exertional dyspnea (HP:0002875)	1.60639806
71	Abnormality of dental color (HP:0011073)	1.59909499
72	Short middle phalanx of the 5th finger (HP:0004220)	1.57496408
73	Chronic obstructive pulmonary disease (HP:0006510)	1.57365120
74	Obstructive lung disease (HP:0006536)	1.57365120
75	Purpura (HP:0000979)	1.55016966
76	Mitochondrial inheritance (HP:0001427)	1.54365514
77	Abnormality of nail color (HP:0100643)	1.50646973
78	Onycholysis (HP:0001806)	1.50526037
79	Anhidrosis (HP:0000970)	1.50026004
80	Ventricular fibrillation (HP:0001663)	1.46859645
81	Birth length less than 3rd percentile (HP:0003561)	1.45442070
82	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.43642041
83	Abnormality of alanine metabolism (HP:0010916)	1.43642041
84	Hyperalaninemia (HP:0003348)	1.43642041
85	Generalized aminoaciduria (HP:0002909)	1.42750534
86	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.41791511
87	Abnormality of the anterior horn cell (HP:0006802)	1.41279106
88	Degeneration of anterior horn cells (HP:0002398)	1.41279106
89	Severe visual impairment (HP:0001141)	1.40625101
90	Renal tubular acidosis (HP:0001947)	1.38659763
91	Increased CSF lactate (HP:0002490)	1.38431230
92	Renal Fanconi syndrome (HP:0001994)	1.37340468
93	Increased intramyocellular lipid droplets (HP:0012240)	1.37244424
94	Cerebral edema (HP:0002181)	1.37038008
95	Increased muscle lipid content (HP:0009058)	1.34927323
96	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.34331092
97	Gingival bleeding (HP:0000225)	1.34005066
98	Confusion (HP:0001289)	1.32132828
99	Gastrointestinal dysmotility (HP:0002579)	1.32100528
100	Anorexia (HP:0002039)	1.32059241

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	9.71259400
2	RIPK4	2.50493134
3	BMX	2.44212842
4	TRPM7	2.39994928
5	CLK1	2.36032664
6	SCYL2	2.30309423
7	TLK1	2.24330263
8	GRK6	2.11028082
9	PIM1	2.01583381
10	TAOK2	1.90349928
11	MAP2K3	1.80179940
12	RPS6KA5	1.75148500
13	DYRK3	1.74904294
14	PRPF4B	1.74502296
15	ZAK	1.71011584
16	MAP3K11	1.70451739
17	TAOK3	1.62453720
18	SYK	1.61690704
19	CDC7	1.50818385
20	STK4	1.48648933
21	MST4	1.44574534
22	TAOK1	1.26661167
23	IKBKB	1.13644725
24	PLK4	1.12931046
25	BMPR2	1.12882221
26	NEK2	1.12651970
27	TEC	1.09056723
28	MAP2K1	1.04159222
29	PTK2B	1.03595361
30	WNK1	1.03100070
31	INSRR	1.00128297
32	CHEK2	0.98841649
33	BTK	0.98782781
34	RAF1	0.96368403
35	NUAK1	0.94133493
36	CCNB1	0.92373103
37	BUB1	0.90752642
38	TTK	0.89703581
39	RPS6KC1	0.87450625
40	RPS6KL1	0.87450625
41	MARK3	0.87261745
42	JAK3	0.86441080
43	MAPK12	0.85524363
44	STK3	0.84738437
45	RPS6KA6	0.81795894
46	MAP3K3	0.81654572
47	PRKCQ	0.81634345
48	DYRK2	0.81382633
49	ABL2	0.79142267
50	PDK2	0.78785110
51	MAP3K8	0.76516294
52	MATK	0.75724313
53	NME2	0.75701061
54	MAP3K5	0.73625155
55	PLK1	0.72335502
56	PLK3	0.71887043
57	TESK2	0.68820169
58	GRK5	0.67529574
59	MAP2K2	0.66789616
60	PIM2	0.65273923
61	MAPK11	0.63868429
62	LYN	0.62907681
63	BCKDK	0.61738019
64	RPS6KA2	0.59845666
65	SGK1	0.58326397
66	HIPK2	0.58106420
67	STK16	0.58091855
68	ILK	0.57466791
69	JAK2	0.55530499
70	KSR2	0.55093831
71	PRKACG	0.50457666
72	MAP3K1	0.50288224
73	ATM	0.50120543
74	IKBKE	0.48978015
75	CSNK2A1	0.47811764
76	MAPKAPK3	0.45849134
77	PINK1	0.45835707
78	TXK	0.45394374
79	DMPK	0.45063938
80	WEE1	0.44835139
81	CDK4	0.43453987
82	CSNK2A2	0.43235100
83	MAPK13	0.41849702
84	AURKA	0.37283188
85	VRK1	0.34766938
86	DYRK1A	0.34546746
87	CHEK1	0.34357445
88	BRSK2	0.34294947
89	KDR	0.33989681
90	MAP4K2	0.33633167
91	MAP3K2	0.33394799
92	MAPKAPK5	0.33359269
93	RPS6KB2	0.32096088
94	ZAP70	0.31580248
95	TNK2	0.31173968
96	RPS6KB1	0.31121142
97	ATR	0.30885600
98	MAP4K1	0.30764739
99	MAP2K6	0.29398944
100	SGK3	0.29022178

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	6.23729880
2	Malaria_Homo sapiens_hsa05144	3.56535246
3	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.27230601
4	Ribosome_Homo sapiens_hsa03010	3.13824776
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.95292117
6	DNA replication_Homo sapiens_hsa03030	2.63295093
7	One carbon pool by folate_Homo sapiens_hsa00670	2.42464700
8	Sulfur relay system_Homo sapiens_hsa04122	2.36366123
9	Mismatch repair_Homo sapiens_hsa03430	2.30582185
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.24632828
11	Parkinsons disease_Homo sapiens_hsa05012	2.12028314
12	Collecting duct acid secretion_Homo sapiens_hsa04966	2.11281459
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.11168354
14	Nucleotide excision repair_Homo sapiens_hsa03420	2.10292470
15	Homologous recombination_Homo sapiens_hsa03440	1.95100936
16	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.76573086
17	Sulfur metabolism_Homo sapiens_hsa00920	1.68403920
18	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.63808905
19	Base excision repair_Homo sapiens_hsa03410	1.63595083
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.62004964
21	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.60408505
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.56357805
23	Huntingtons disease_Homo sapiens_hsa05016	1.47892269
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.47187682
25	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.46992044
26	Cell cycle_Homo sapiens_hsa04110	1.46760028
27	Proteasome_Homo sapiens_hsa03050	1.42784018
28	African trypanosomiasis_Homo sapiens_hsa05143	1.41658310
29	Asthma_Homo sapiens_hsa05310	1.35466755
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.32807455
31	RNA polymerase_Homo sapiens_hsa03020	1.31577605
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.25189144
33	Regulation of autophagy_Homo sapiens_hsa04140	1.22845556
34	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.18910202
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.18631675
36	Basal transcription factors_Homo sapiens_hsa03022	1.08666157
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05581515
38	Alzheimers disease_Homo sapiens_hsa05010	1.00591044
39	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.99975437
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.99808032
41	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.88228750
42	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.87297131
43	Spliceosome_Homo sapiens_hsa03040	0.85490883
44	Pyruvate metabolism_Homo sapiens_hsa00620	0.84988976
45	ABC transporters_Homo sapiens_hsa02010	0.82159252
46	Purine metabolism_Homo sapiens_hsa00230	0.77278042
47	RNA transport_Homo sapiens_hsa03013	0.77229236
48	mRNA surveillance pathway_Homo sapiens_hsa03015	0.76597313
49	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.74035139
50	Non-small cell lung cancer_Homo sapiens_hsa05223	0.72492831
51	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.71180135
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.70630415
53	Alcoholism_Homo sapiens_hsa05034	0.70628996
54	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.66736787
55	RNA degradation_Homo sapiens_hsa03018	0.65082566
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.62388656
57	Herpes simplex infection_Homo sapiens_hsa05168	0.62343057
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61708489
59	Folate biosynthesis_Homo sapiens_hsa00790	0.56678435
60	Metabolic pathways_Homo sapiens_hsa01100	0.55022109
61	Apoptosis_Homo sapiens_hsa04210	0.53317070
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52558216
63	Cardiac muscle contraction_Homo sapiens_hsa04260	0.52151074
64	Viral carcinogenesis_Homo sapiens_hsa05203	0.51525436
65	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.49451167
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.48809304
67	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.48763230
68	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.47267798
69	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.46961628
70	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.42870181
71	p53 signaling pathway_Homo sapiens_hsa04115	0.40681343
72	Platelet activation_Homo sapiens_hsa04611	0.40637684
73	Acute myeloid leukemia_Homo sapiens_hsa05221	0.39128504
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.38806313
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.37441996
76	Oocyte meiosis_Homo sapiens_hsa04114	0.36937897
77	Graft-versus-host disease_Homo sapiens_hsa05332	0.35602177
78	Bladder cancer_Homo sapiens_hsa05219	0.32908291
79	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.32645559
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.32598307
81	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.32169324
82	Thyroid cancer_Homo sapiens_hsa05216	0.31426578
83	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.30684049
84	Measles_Homo sapiens_hsa05162	0.30211444
85	Olfactory transduction_Homo sapiens_hsa04740	0.29832376
86	Nicotine addiction_Homo sapiens_hsa05033	0.29096886
87	Allograft rejection_Homo sapiens_hsa05330	0.27895152
88	mTOR signaling pathway_Homo sapiens_hsa04150	0.27322612
89	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.27120946
90	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.26716808
91	Pancreatic cancer_Homo sapiens_hsa05212	0.25236787
92	Glutathione metabolism_Homo sapiens_hsa00480	0.25013801
93	Type II diabetes mellitus_Homo sapiens_hsa04930	0.24389170
94	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.23835309
95	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.23752452
96	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.23602446
97	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.23221019
98	Primary immunodeficiency_Homo sapiens_hsa05340	0.22111418
99	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.21256660
100	Protein export_Homo sapiens_hsa03060	0.21104135

RHCE

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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