RHCG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)9.96630011
2polyketide metabolic process (GO:0030638)9.96630011
3doxorubicin metabolic process (GO:0044598)9.96630011
4establishment of skin barrier (GO:0061436)9.78894140
5regulation of water loss via skin (GO:0033561)8.61832170
6epidermis development (GO:0008544)7.33467691
7regulation of response to osmotic stress (GO:0047484)6.79373353
8keratinocyte proliferation (GO:0043616)6.30844926
9organic cation transport (GO:0015695)6.29349330
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.16542846
11multicellular organismal water homeostasis (GO:0050891)6.14458299
12maintenance of protein location in nucleus (GO:0051457)6.01863474
13establishment of planar polarity (GO:0001736)5.90317007
14establishment of tissue polarity (GO:0007164)5.90317007
15somite rostral/caudal axis specification (GO:0032525)5.79897657
16regulation of cilium movement (GO:0003352)5.79149142
17negative regulation of epidermis development (GO:0045683)5.74240524
18detection of bacterium (GO:0016045)5.67495704
19regulation of mammary gland epithelial cell proliferation (GO:0033599)5.57295093
20ectoderm development (GO:0007398)5.50383289
21negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.49441510
22cellular modified amino acid catabolic process (GO:0042219)5.45846236
23cytidine metabolic process (GO:0046087)5.45319202
24cytidine catabolic process (GO:0006216)5.45319202
25cytidine deamination (GO:0009972)5.45319202
26eyelid development in camera-type eye (GO:0061029)5.29975721
27detection of other organism (GO:0098543)5.23549275
28hair cycle (GO:0042633)5.22381959
29molting cycle (GO:0042303)5.22381959
30hormone catabolic process (GO:0042447)5.20350041
31planar cell polarity pathway involved in neural tube closure (GO:0090179)5.19432232
32regulation of apoptotic process involved in morphogenesis (GO:1902337)5.16762862
33water homeostasis (GO:0030104)5.14322881
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.90397985
35muscle organ morphogenesis (GO:0048644)4.88706612
36negative regulation of cell cycle G2/M phase transition (GO:1902750)4.87944105
37lipoxygenase pathway (GO:0019372)4.85861320
38negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.85618955
39pyrimidine ribonucleoside catabolic process (GO:0046133)4.80401688
40gap junction assembly (GO:0016264)4.79452494
41protein localization to kinetochore (GO:0034501)4.72167400
42histone H4-K8 acetylation (GO:0043982)4.65968879
43histone H4-K5 acetylation (GO:0043981)4.65968879
44coenzyme catabolic process (GO:0009109)4.58292571
45regulation of natural killer cell differentiation (GO:0032823)4.54220863
46hair follicle morphogenesis (GO:0031069)4.50730584
47regulation of MHC class I biosynthetic process (GO:0045343)4.48906987
48negative regulation of telomerase activity (GO:0051974)4.47542147
49negative regulation of interferon-gamma production (GO:0032689)4.47391824
50rRNA transcription (GO:0009303)4.46871617
51regulation of nuclear cell cycle DNA replication (GO:0033262)4.46817860
52regulation of telomere maintenance via telomerase (GO:0032210)4.43686850
53positive regulation of monocyte chemotaxis (GO:0090026)4.41696753
54negative regulation of epidermal cell differentiation (GO:0045605)4.39469323
55apical protein localization (GO:0045176)4.36851779
56notochord development (GO:0030903)4.30042364
57long-chain fatty acid biosynthetic process (GO:0042759)4.29373809
58regulation of ruffle assembly (GO:1900027)4.26215764
59urate metabolic process (GO:0046415)4.22400365
60cardiovascular system development (GO:0072358)4.21848629
61histone H4-K12 acetylation (GO:0043983)4.21441898
62response to phenylpropanoid (GO:0080184)4.20745661
63hemidesmosome assembly (GO:0031581)4.19289167
64heterochromatin organization (GO:0070828)4.15716503
65response to dietary excess (GO:0002021)4.09835907
66positive regulation of epidermis development (GO:0045684)4.08138949
67positive regulation of chemokine biosynthetic process (GO:0045080)4.04068267
68biotin metabolic process (GO:0006768)3.99291265
69phenol-containing compound catabolic process (GO:0019336)3.96478481
70rRNA methylation (GO:0031167)3.94415127
71nucleoside transmembrane transport (GO:1901642)3.94280140
72interferon-gamma production (GO:0032609)3.93695621
73modified amino acid transport (GO:0072337)3.92547631
74quaternary ammonium group transport (GO:0015697)3.91529147
75drug transmembrane transport (GO:0006855)3.90657391
76sulfur amino acid catabolic process (GO:0000098)3.90600511
77sequestering of metal ion (GO:0051238)3.89447972
78mitotic sister chromatid segregation (GO:0000070)3.88749411
79positive regulation of digestive system process (GO:0060456)3.87091396
80seminiferous tubule development (GO:0072520)3.84311627
81regulation of microtubule-based movement (GO:0060632)3.80772139
82excretion (GO:0007588)3.80594791
83keratinocyte development (GO:0003334)3.80240131
84quinone metabolic process (GO:1901661)3.77875589
85epoxygenase P450 pathway (GO:0019373)3.77392567
86protein localization to chromosome, centromeric region (GO:0071459)3.73204939
87linoleic acid metabolic process (GO:0043651)3.70953917
88microtubule severing (GO:0051013)3.67349897
89positive regulation of epidermal cell differentiation (GO:0045606)3.65800286
90branching involved in mammary gland duct morphogenesis (GO:0060444)3.65429740
91L-ascorbic acid metabolic process (GO:0019852)3.58147913
92hypotonic response (GO:0006971)3.57040768
93primitive streak formation (GO:0090009)3.54466958
94positive regulation of DNA-dependent DNA replication (GO:2000105)3.54184683
95cofactor transport (GO:0051181)3.53585804
96rRNA modification (GO:0000154)3.52681431
97negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.51883094
98ventricular system development (GO:0021591)3.47222421
99DNA replication-dependent nucleosome organization (GO:0034723)3.46585096
100DNA replication-dependent nucleosome assembly (GO:0006335)3.46585096
101maintenance of protein localization in organelle (GO:0072595)3.46096607
102negative regulation of keratinocyte proliferation (GO:0010839)3.46093855
103phosphate ion transport (GO:0006817)3.46008933
104chromatin assembly (GO:0031497)3.43218334
105hair cell differentiation (GO:0035315)3.41545408
106histone H4-K16 acetylation (GO:0043984)3.41287810
107regulation of monocyte chemotaxis (GO:0090025)3.40557235
108membrane raft organization (GO:0031579)3.39753542
109icosanoid secretion (GO:0032309)3.39544937
110arachidonic acid secretion (GO:0050482)3.39544937
111leukocyte aggregation (GO:0070486)3.38024013
112valine metabolic process (GO:0006573)3.37219662
113glycoside metabolic process (GO:0016137)3.37101340
114asymmetric protein localization (GO:0008105)3.36646293
115drug transport (GO:0015893)3.35757849
116regulation of chemokine biosynthetic process (GO:0045073)3.35533613
117* epithelial cell differentiation (GO:0030855)3.35432440
118positive regulation of p38MAPK cascade (GO:1900745)3.35068034
119chronic inflammatory response (GO:0002544)3.34532343
120intermediate filament organization (GO:0045109)3.33777381
121negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.33381977
122epithelium development (GO:0060429)3.33351821
123mitochondrion distribution (GO:0048311)3.32611494
124nuclear pore complex assembly (GO:0051292)3.30732138
125fat-soluble vitamin metabolic process (GO:0006775)3.26161767
126regulation of hippo signaling (GO:0035330)3.22493551
127protein polyglutamylation (GO:0018095)3.22359337
128vitamin A metabolic process (GO:0006776)3.22348363
129vitamin D metabolic process (GO:0042359)3.22045345
130lysine metabolic process (GO:0006553)3.21252172
131lysine catabolic process (GO:0006554)3.21252172
132negative regulation of interleukin-17 production (GO:0032700)3.20879391
133tachykinin receptor signaling pathway (GO:0007217)3.20581421
134fusion of sperm to egg plasma membrane (GO:0007342)3.19586640
135regulation of translation in response to stress (GO:0043555)3.19299789
136negative regulation of telomere maintenance (GO:0032205)3.18833666
137localization within membrane (GO:0051668)3.18669503
138positive regulation of protein deacetylation (GO:0090312)3.15736384
139negative regulation of bone mineralization (GO:0030502)3.13360793
140citrulline biosynthetic process (GO:0019240)3.11166158
141sulfur compound transport (GO:0072348)3.10812836
142sister chromatid segregation (GO:0000819)3.09097267
143detection of external biotic stimulus (GO:0098581)3.08021253
144drug metabolic process (GO:0017144)3.07486484
145regulation of T cell migration (GO:2000404)3.06881025
146proline transport (GO:0015824)3.04402438
147regulation of membrane protein ectodomain proteolysis (GO:0051043)3.03988351
148response to mercury ion (GO:0046689)3.03200523
149cell fate commitment involved in formation of primary germ layer (GO:0060795)3.01760293
150regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.01555297
151keratinization (GO:0031424)21.8909283
152positive regulation of T cell chemotaxis (GO:0010820)2.99579199
153regulation of T cell chemotaxis (GO:0010819)2.99579199
154intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.97514239
155branched-chain amino acid metabolic process (GO:0009081)2.95983633
156regulation of natural killer cell activation (GO:0032814)2.95781355
157Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.93671816
158intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.93549739
159intermediate filament cytoskeleton organization (GO:0045104)2.93254877
160lateral sprouting from an epithelium (GO:0060601)2.90518735
161primary alcohol catabolic process (GO:0034310)2.87696884
162regulation of establishment of planar polarity (GO:0090175)2.85814466
163wound healing (GO:0042060)2.84558499
164positive regulation of Cdc42 GTPase activity (GO:0043089)2.84031173
165regulation of epidermis development (GO:0045682)2.83849290
166intermediate filament-based process (GO:0045103)2.82099949
167positive regulation of keratinocyte differentiation (GO:0045618)2.81485406
168negative regulation of biomineral tissue development (GO:0070168)2.81008920
169regulation of neuron projection regeneration (GO:0070570)2.77959008
170regulation of axon regeneration (GO:0048679)2.77959008
171cochlea morphogenesis (GO:0090103)2.77821566
172regulation of vitamin D biosynthetic process (GO:0060556)2.74676183
173negative regulation of cell-cell adhesion (GO:0022408)2.68845739
174protein localization to endosome (GO:0036010)2.68198112
175skin morphogenesis (GO:0043589)2.66280765
176epithelial cell-cell adhesion (GO:0090136)2.66000383
177detection of biotic stimulus (GO:0009595)2.63873954
178regulation of keratinocyte differentiation (GO:0045616)2.61182232
179regulation of p38MAPK cascade (GO:1900744)2.58710368
180regulation of type 2 immune response (GO:0002828)2.57498934
181positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.46722510
182negative regulation of cell-substrate adhesion (GO:0010812)2.45737559
183negative regulation of response to cytokine stimulus (GO:0060761)2.45260070
184branching involved in labyrinthine layer morphogenesis (GO:0060670)2.45120170
185positive regulation of vesicle fusion (GO:0031340)2.44255060
186atrioventricular valve morphogenesis (GO:0003181)2.43008271
187negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.42628027
188hair cycle process (GO:0022405)2.38768054
189molting cycle process (GO:0022404)2.38768054
190regulation of keratinocyte proliferation (GO:0010837)2.38572363
191ventricular cardiac muscle cell action potential (GO:0086005)2.38259668
192epithelial cell differentiation involved in prostate gland development (GO:0060742)2.37766014
193negative regulation of cytokine-mediated signaling pathway (GO:0001960)2.36697741
194regulation of lymphocyte migration (GO:2000401)2.35487721
195peptide cross-linking (GO:0018149)17.0810173
196keratinocyte differentiation (GO:0030216)14.8996632
197epidermal cell differentiation (GO:0009913)11.6800712
198aminoglycoside antibiotic metabolic process (GO:0030647)11.5232775
199desmosome organization (GO:0002934)11.3457187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.55135512
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.55135512
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.55135512
4BP1_19119308_ChIP-ChIP_Hs578T_Human6.51520362
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.60608132
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.20110984
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.00122020
8P63_26484246_Chip-Seq_KERATINOCYTES_Human3.62364977
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.59214109
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.49961491
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.16762567
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.87981288
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.86379047
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.67658895
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.66989367
16* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.59028690
17* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.59028690
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.57436309
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.57406704
20TCF3_18692474_ChIP-Seq_MESCs_Mouse2.47003620
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.42761694
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.38696462
23NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.25673880
24* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.23518129
25NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.16772046
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.12399466
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.08324641
28NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.07129607
29STAT3_1855785_ChIP-Seq_MESCs_Mouse2.03371815
30TP63_17297297_ChIP-ChIP_HaCaT_Human11.5387166
31* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92842725
32SOX2_20726797_ChIP-Seq_SW620_Human1.88107851
33SOX9_24532713_ChIP-Seq_HFSC_Mouse1.86072560
34KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.85871498
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82984445
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.82257633
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80532046
38IRF1_19129219_ChIP-ChIP_H3396_Human1.77865106
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.77819294
40NANOG_18692474_ChIP-Seq_MEFs_Mouse1.73274550
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73054076
42POU5F1_16518401_ChIP-PET_MESCs_Mouse1.70402204
43E2F7_22180533_ChIP-Seq_HELA_Human1.69367367
44TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.67272812
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65839645
46NANOG_18692474_ChIP-Seq_MESCs_Mouse1.65539731
47CDX2_20551321_ChIP-Seq_CACO-2_Human1.65060373
48* ATF3_27146783_Chip-Seq_COLON_Human1.64232722
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.62937135
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57277567
51E2F1_17053090_ChIP-ChIP_MCF-7_Human1.56038611
52POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.55274293
53* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.54364567
54PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.52932096
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.50381264
56GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.49611370
57KLF5_25053715_ChIP-Seq_YYC3_Human1.49453720
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48900247
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44503341
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.40591648
61* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40302748
62* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.37624378
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37053714
64SOX2_18692474_ChIP-Seq_MESCs_Mouse1.35482083
65TP63_23658742_ChIP-Seq_EP156T_Human1.34749745
66E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30690214
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28766100
68GATA3_24758297_ChIP-Seq_MCF-7_Human1.28243898
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27730218
70* NANOG_16518401_ChIP-PET_MESCs_Mouse1.27556308
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26698774
72OCT4_18692474_ChIP-Seq_MEFs_Mouse1.26026255
73SOX2_18692474_ChIP-Seq_MEFs_Mouse1.24258510
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22810048
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22704920
76SMC4_20622854_ChIP-Seq_HELA_Human1.21807254
77* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19283403
78GATA6_21074721_ChIP-Seq_CACO-2_Human1.19023191
79RXR_22108803_ChIP-Seq_LS180_Human1.17764184
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17092109
81TP53_22127205_ChIP-Seq_IMR90_Human1.16729595
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13833162
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10838787
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09574700
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.09499679
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09362217
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.08273850
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08081314
89* CTCF_27219007_Chip-Seq_Bcells_Human1.07262028
90PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06497824
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05310997
92CJUN_26792858_Chip-Seq_BT549_Human1.05295101
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03622834
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.01828160
95* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00797212
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.00277649
97CLOCK_20551151_ChIP-Seq_293T_Human0.99857001
98CTCF_20526341_ChIP-Seq_ESCs_Human0.98551783
99SA1_27219007_Chip-Seq_Bcells_Human0.98442591
100SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98397875
101NANOG_21062744_ChIP-ChIP_HESCs_Human0.98308789
102FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97961026
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97536352
104P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.97438822
105TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96803529
106UBF1/2_26484160_Chip-Seq_HMECs_Human0.96646286
107AR_21909140_ChIP-Seq_LNCAP_Human0.96348121
108* ERG_20517297_ChIP-Seq_VCAP_Human0.95685895
109CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95576833
110* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95363174
111FOXM1_23109430_ChIP-Seq_U2OS_Human0.94786232
112NANOG_16153702_ChIP-ChIP_HESCs_Human0.94719643
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93926160
114P68_20966046_ChIP-Seq_HELA_Human0.93685398
115LXR_22292898_ChIP-Seq_THP-1_Human0.93602456
116ESET_19884257_ChIP-Seq_ESCs_Mouse0.93590874
117NCOR1_26117541_ChIP-Seq_K562_Human0.93364247
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92943196
119E2F1_20622854_ChIP-Seq_HELA_Human0.92891540
120YY1_22570637_ChIP-Seq_MALME-3M_Human0.92622662
121* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91960873
122TCF4_18268006_ChIP-ChIP_LS174T_Human0.91841837
123PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91673427
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91340504
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90420589
126FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90106566
127SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.90016556
128RACK7_27058665_Chip-Seq_MCF-7_Human0.89430098
129ELF1_20517297_ChIP-Seq_JURKAT_Human0.89147656
130POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88992347
131EGR1_19032775_ChIP-ChIP_M12_Human0.88442637
132GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87938863
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.87678245
134GATA6_25053715_ChIP-Seq_YYC3_Human0.86959577
135NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85843735
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85669791
137MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84961927
138CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.84884307
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84824147
140STAT3_18555785_ChIP-Seq_MESCs_Mouse0.84630784
141TET1_21451524_ChIP-Seq_MESCs_Mouse0.84600256
142BCOR_27268052_Chip-Seq_Bcells_Human0.84381552
143SMAD_19615063_ChIP-ChIP_OVARY_Human0.84334519
144ESR1_21235772_ChIP-Seq_MCF-7_Human0.83992165
145RXR_22158963_ChIP-Seq_LIVER_Mouse0.83444088
146KAP1_27257070_Chip-Seq_ESCs_Mouse0.82942960
147MYC_19079543_ChIP-ChIP_MESCs_Mouse0.82712058
148GATA1_19941826_ChIP-Seq_K562_Human0.82632153
149SPI1_26923725_Chip-Seq_HPCs_Mouse0.82584880
150RNF2_27304074_Chip-Seq_NSC_Mouse0.82548083
151* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.81472295
152CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81428380
153KDM2B_26808549_Chip-Seq_DND41_Human0.80696830
154* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80695273
155* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.80209236
156CTCF_21964334_Chip-Seq_Bcells_Human0.79844361
157* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.79696697
158* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.79619526
159POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.79335614
160RBPJ_21746931_ChIP-Seq_IB4_Human0.78480399
161VDR_22108803_ChIP-Seq_LS180_Human0.77916571
162* TCF7_22412390_ChIP-Seq_EML_Mouse0.77684392
163GATA4_25053715_ChIP-Seq_YYC3_Human0.77498498
164HTT_18923047_ChIP-ChIP_STHdh_Human0.77437141
165KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77423323
166SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76695937
167SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76036923
168Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75792142
169RXRA_24833708_ChIP-Seq_LIVER_Mouse0.75172487
170SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.74841437
171IKZF1_21737484_ChIP-ChIP_HCT116_Human0.73947697
172* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.73875955
173TRIM28_21343339_ChIP-Seq_HEK293_Human0.73816459
174ELK4_26923725_Chip-Seq_MESODERM_Mouse0.72529669
175GATA2_21666600_ChIP-Seq_HMVEC_Human0.71514760
176BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70333812
177SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69967251
178FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69526540
179TP63_22573176_ChIP-Seq_HFKS_Human0.69514358
180* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.69251448
181TBX20_22328084_ChIP-Seq_HEART_Mouse0.68184146
182TBX20_22080862_ChIP-Seq_HEART_Mouse0.68184146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.64635517
2MP0004264_abnormal_extraembryonic_tissu4.53245034
3MP0005501_abnormal_skin_physiology4.51825206
4MP0002254_reproductive_system_inflammat4.43229381
5MP0000579_abnormal_nail_morphology4.42166135
6MP0005275_abnormal_skin_tensile4.35643368
7MP0000467_abnormal_esophagus_morphology4.00602114
8MP0003453_abnormal_keratinocyte_physiol3.62719373
9MP0004858_abnormal_nervous_system3.49258236
10MP0006292_abnormal_olfactory_placode3.37736002
11MP0010678_abnormal_skin_adnexa3.29965958
12MP0003890_abnormal_embryonic-extraembry2.97353023
13MP0005499_abnormal_olfactory_system2.96843242
14MP0005394_taste/olfaction_phenotype2.96843242
15MP0001216_abnormal_epidermal_layer2.92974134
16MP0008961_abnormal_basal_metabolism2.77729898
17MP0002653_abnormal_ependyma_morphology2.64077997
18MP0002332_abnormal_exercise_endurance2.58699237
19MP0005360_urolithiasis2.55245833
20MP0005075_abnormal_melanosome_morpholog2.54022115
21MP0003122_maternal_imprinting2.51183774
22MP0005410_abnormal_fertilization2.50350617
23* MP0004043_abnormal_pH_regulation2.46032011
24MP0006035_abnormal_mitochondrial_morpho2.42353526
25MP0010771_integument_phenotype2.32971210
26MP0004019_abnormal_vitamin_homeostasis2.29157005
27MP0005257_abnormal_intraocular_pressure2.19336808
28MP0000678_abnormal_parathyroid_gland2.14104153
29MP0009053_abnormal_anal_canal2.13179851
30MP0003705_abnormal_hypodermis_morpholog2.09422492
31MP0005332_abnormal_amino_acid2.08858017
32MP0000383_abnormal_hair_follicle2.08356450
33MP0002095_abnormal_skin_pigmentation2.01310736
34MP0004957_abnormal_blastocyst_morpholog2.00117000
35MP0010234_abnormal_vibrissa_follicle10.0988908
36MP0008057_abnormal_DNA_replication1.98733761
37MP0000465_gastrointestinal_hemorrhage1.97982698
38MP0002060_abnormal_skin_morphology1.89557128
39MP0003183_abnormal_peptide_metabolism1.87651543
40MP0003938_abnormal_ear_development1.80196151
41MP0004947_skin_inflammation1.73848282
42MP0003121_genomic_imprinting1.73586574
43MP0000377_abnormal_hair_follicle1.69539317
44MP0003941_abnormal_skin_development1.67078002
45MP0001293_anophthalmia1.65242950
46MP0001756_abnormal_urination1.64877153
47* MP0009643_abnormal_urine_homeostasis1.63828022
48MP0003566_abnormal_cell_adhesion1.57916174
49* MP0001765_abnormal_ion_homeostasis1.54284097
50MP0001851_eye_inflammation1.51121372
51MP0003195_calcinosis1.50731538
52MP0001849_ear_inflammation1.49702540
53MP0005380_embryogenesis_phenotype1.49379836
54MP0001672_abnormal_embryogenesis/_devel1.49379836
55MP0001243_abnormal_dermal_layer1.46956189
56MP0000566_synostosis1.44907951
57MP0002088_abnormal_embryonic_growth/wei1.42675395
58MP0002932_abnormal_joint_morphology1.42342169
59MP0006082_CNS_inflammation1.41280697
60MP0000371_diluted_coat_color1.40880573
61MP0003984_embryonic_growth_retardation1.40691686
62MP0002092_abnormal_eye_morphology1.37258160
63MP0010352_gastrointestinal_tract_polyps1.34387947
64MP0004185_abnormal_adipocyte_glucose1.33392894
65MP0003283_abnormal_digestive_organ1.32666933
66MP0002127_abnormal_cardiovascular_syste1.31991098
67MP0010030_abnormal_orbit_morphology1.31952947
68MP0000762_abnormal_tongue_morphology1.31211991
69MP0009931_abnormal_skin_appearance1.31047514
70MP0005377_hearing/vestibular/ear_phenot1.30692975
71MP0003878_abnormal_ear_physiology1.30692975
72* MP0002136_abnormal_kidney_physiology1.25515918
73MP0003315_abnormal_perineum_morphology1.21441993
74MP0000427_abnormal_hair_cycle1.20189890
75MP0005266_abnormal_metabolism1.16658418
76MP0006036_abnormal_mitochondrial_physio1.16180691
77MP0005023_abnormal_wound_healing1.14823306
78MP0002277_abnormal_respiratory_mucosa1.14470425
79MP0005319_abnormal_enzyme/_coenzyme1.14363449
80MP0003123_paternal_imprinting1.13881557
81MP0000367_abnormal_coat/_hair1.12243663
82MP0003186_abnormal_redox_activity1.10281323
83MP0005409_darkened_coat_color1.09076169
84MP0003303_peritoneal_inflammation1.07464251
85MP0002114_abnormal_axial_skeleton1.05807678
86MP0000470_abnormal_stomach_morphology1.04328508
87* MP0005636_abnormal_mineral_homeostasis1.04315755
88MP0008875_abnormal_xenobiotic_pharmacok1.03884350
89MP0000049_abnormal_middle_ear1.03746467
90MP0004381_abnormal_hair_follicle1.02365537
91MP0002233_abnormal_nose_morphology1.00454866
92MP0002139_abnormal_hepatobiliary_system0.98469308
93MP0002085_abnormal_embryonic_tissue0.97945115
94MP0002086_abnormal_extraembryonic_tissu0.97692376
95MP0000432_abnormal_head_morphology0.97254473
96MP0003191_abnormal_cellular_cholesterol0.96834546
97MP0002970_abnormal_white_adipose0.96765118
98MP0008789_abnormal_olfactory_epithelium0.92550019
99MP0005666_abnormal_adipose_tissue0.91866960
100MP0002084_abnormal_developmental_patter0.87655747
101MP0002234_abnormal_pharynx_morphology0.86240450
102MP0004885_abnormal_endolymph0.83822779
103MP0001348_abnormal_lacrimal_gland0.81508508
104MP0003724_increased_susceptibility_to0.79758123
105MP0000428_abnormal_craniofacial_morphol0.77986496
106MP0000350_abnormal_cell_proliferation0.76999328
107MP0001191_abnormal_skin_condition0.76778339
108MP0004133_heterotaxia0.76386748
109MP0002098_abnormal_vibrissa_morphology0.76194716
110MP0008004_abnormal_stomach_pH0.75271636
111MP0003137_abnormal_impulse_conducting0.75264749
112MP0005670_abnormal_white_adipose0.74913173
113* MP0003698_abnormal_male_reproductive0.73723144
114MP0003935_abnormal_craniofacial_develop0.72889262
115MP0005391_vision/eye_phenotype0.72755356
116MP0003252_abnormal_bile_duct0.72235678
117MP0001270_distended_abdomen0.71659902
118MP0001929_abnormal_gametogenesis0.70939675
119MP0000358_abnormal_cell_content/0.70758915
120MP0002396_abnormal_hematopoietic_system0.70433341
121MP0003436_decreased_susceptibility_to0.69928240
122MP0002269_muscular_atrophy0.68692685
123MP0008770_decreased_survivor_rate0.68206386
124MP0009785_altered_susceptibility_to0.68206137
125MP0002796_impaired_skin_barrier0.67539169
126MP0003755_abnormal_palate_morphology0.67258648
127MP0009703_decreased_birth_body0.66863224
128MP0002116_abnormal_craniofacial_bone0.66756046
129MP0002148_abnormal_hypersensitivity_rea0.64920522
130MP0000750_abnormal_muscle_regeneration0.63401566
131MP0002138_abnormal_hepatobiliary_system0.63086169
132MP0003950_abnormal_plasma_membrane0.62110438
133* MP0001145_abnormal_male_reproductive0.62080462
134MP0001697_abnormal_embryo_size0.61592391
135MP0000313_abnormal_cell_death0.61022340
136MP0004782_abnormal_surfactant_physiolog0.60834853
137MP0005375_adipose_tissue_phenotype0.60539457
138MP0003119_abnormal_digestive_system0.59814742
139MP0001784_abnormal_fluid_regulation0.59798757
140MP0008872_abnormal_physiological_respon0.59252467
141MP0000534_abnormal_ureter_morphology0.59237495
142MP0000163_abnormal_cartilage_morphology0.59030347
143MP0004272_abnormal_basement_membrane0.58873585
144MP0003806_abnormal_nucleotide_metabolis0.58366439
145MP0005623_abnormal_meninges_morphology0.58135725
146MP0002075_abnormal_coat/hair_pigmentati0.57996020
147MP0005451_abnormal_body_composition0.55435221
148MP0000647_abnormal_sebaceous_gland0.55325623
149MP0001533_abnormal_skeleton_physiology0.50275619
150MP0005025_abnormal_response_to0.47791741
151MP0003075_altered_response_to0.47636029
152MP0005193_abnormal_anterior_eye0.47247523
153MP0002111_abnormal_tail_morphology0.44450359
154MP0001186_pigmentation_phenotype0.44277835
155MP0001790_abnormal_immune_system0.43454432
156MP0005387_immune_system_phenotype0.43454432
157MP0004510_myositis0.43224215
158MP0003300_gastrointestinal_ulcer0.42077654
159MP0005503_abnormal_tendon_morphology0.41837399
160MP0000858_altered_metastatic_potential0.41591042
161MP0009333_abnormal_splenocyte_physiolog0.40646488
162MP0009840_abnormal_foam_cell0.40106340
163MP0001340_abnormal_eyelid_morphology0.40040210
164MP0000685_abnormal_immune_system0.37962528
165MP0009780_abnormal_chondrocyte_physiolo0.37658835
166MP0003638_abnormal_response/metabolism_0.37471335
167MP0003448_altered_tumor_morphology0.35594600
168MP0010155_abnormal_intestine_physiology0.34672101
169MP0005166_decreased_susceptibility_to0.34249124
170MP0002282_abnormal_trachea_morphology0.33555459
171MP0000613_abnormal_salivary_gland0.32692606
172MP0002249_abnormal_larynx_morphology0.32593304
173MP0005164_abnormal_response_to0.30497178
174MP0005000_abnormal_immune_tolerance0.29121275
175MP0001853_heart_inflammation0.29100401
176MP0008260_abnormal_autophagy0.27770845
177MP0002877_abnormal_melanocyte_morpholog0.25569082
178MP0000343_altered_response_to0.25221081
179MP0001485_abnormal_pinna_reflex0.23168544
180MP0001958_emphysema0.22698198
181MP0005390_skeleton_phenotype0.22616012

Predicted human phenotypes

RankGene SetZ-score
1Erythroderma (HP:0001019)8.11966807
2Palmoplantar hyperkeratosis (HP:0000972)7.75464946
3Congenital ichthyosiform erythroderma (HP:0007431)7.58829055
4Palmar hyperkeratosis (HP:0010765)7.35712614
5Increased IgE level (HP:0003212)6.58607970
6Plantar hyperkeratosis (HP:0007556)6.51010739
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.38222097
8Bilateral microphthalmos (HP:0007633)6.24445954
9Alopecia of scalp (HP:0002293)5.68151885
10Lip pit (HP:0100267)5.43953278
11Corneal erosion (HP:0200020)5.33163957
12Hepatoblastoma (HP:0002884)5.29378410
13Gout (HP:0001997)5.20782048
14Increased circulating renin level (HP:0000848)5.13803577
15Hyperactive renin-angiotensin system (HP:0000841)5.02259350
16Onycholysis (HP:0001806)4.98949996
17Hypotrichosis (HP:0001006)4.84280318
18Multiple enchondromatosis (HP:0005701)4.80398689
19Hypokalemic alkalosis (HP:0001949)4.79207720
20Thick nail (HP:0001805)4.78953905
21Hypochromic microcytic anemia (HP:0004840)4.75256001
22Fragile nails (HP:0001808)4.72930370
23Erythema (HP:0010783)4.62995977
24Parakeratosis (HP:0001036)4.59137116
25Ectropion (HP:0000656)4.49259955
26Nail dystrophy (HP:0008404)4.49165399
27Abnormality of secondary sexual hair (HP:0009888)4.42755500
28Abnormality of the axillary hair (HP:0100134)4.42755500
29Abnormality of the lower motor neuron (HP:0002366)4.42590826
30Metabolic alkalosis (HP:0200114)4.39637343
31Right ventricular cardiomyopathy (HP:0011663)4.36191828
32Abnormality of chloride homeostasis (HP:0011422)4.32105511
33Pustule (HP:0200039)4.31134383
34Polyuria (HP:0000103)4.25058199
35Hypomagnesemia (HP:0002917)4.24976990
36Renal salt wasting (HP:0000127)4.13567966
37Abnormal urine output (HP:0012590)3.98131206
38Gangrene (HP:0100758)3.90538241
39Hyperaldosteronism (HP:0000859)3.89333527
40Hypohidrosis (HP:0000966)3.87641909
41Absent eyelashes (HP:0000561)3.73290936
42Abnormality of renal excretion (HP:0011036)3.70113843
43Rib fusion (HP:0000902)3.68550990
44Hyperglycinuria (HP:0003108)3.57829682
45Abnormality of magnesium homeostasis (HP:0004921)3.42878451
46Palmoplantar keratoderma (HP:0000982)3.39481149
47Polydipsia (HP:0001959)3.37195646
48Abnormal drinking behavior (HP:0030082)3.37195646
49Absent hair (HP:0002298)3.32347814
50Hyperuricemia (HP:0002149)3.29841175
51Increased purine levels (HP:0004368)3.29841175
52Neoplasm of striated muscle (HP:0009728)3.28642393
53Sparse scalp hair (HP:0002209)3.20350597
54Abnormality of placental membranes (HP:0011409)3.18850182
55Amniotic constriction ring (HP:0009775)3.18850182
56Ependymoma (HP:0002888)3.18581343
57Abnormality of renin-angiotensin system (HP:0000847)3.15979621
58Sparse eyelashes (HP:0000653)3.08759361
59Rhabdomyosarcoma (HP:0002859)3.03625795
60Woolly hair (HP:0002224)2.98269297
61Malnutrition (HP:0004395)2.96390197
62Tetany (HP:0001281)2.91674251
63Abnormal cartilage morphology (HP:0002763)2.87044557
64Brittle hair (HP:0002299)2.85929736
65Nephroblastoma (Wilms tumor) (HP:0002667)2.85435175
66Dehydration (HP:0001944)2.83803744
67Testicular atrophy (HP:0000029)2.83098371
68Proximal tubulopathy (HP:0000114)2.82023766
69Ragged-red muscle fibers (HP:0003200)2.79747121
70Hyperventilation (HP:0002883)2.77577165
71Partial duplication of thumb phalanx (HP:0009944)2.77517451
72Abnormal blistering of the skin (HP:0008066)2.73806792
73Hyperinsulinemic hypoglycemia (HP:0000825)2.71453462
74Hypoplastic labia majora (HP:0000059)2.70953334
75Urticaria (HP:0001025)2.70910208
76Alkalosis (HP:0001948)2.67444650
77Embryonal renal neoplasm (HP:0011794)2.64367647
78Rectal fistula (HP:0100590)2.64297366
79Rectovaginal fistula (HP:0000143)2.64297366
80Bifid tongue (HP:0010297)2.63677998
81Furrowed tongue (HP:0000221)2.59944348
82Amyotrophic lateral sclerosis (HP:0007354)2.58295139
83Abnormality of glycine metabolism (HP:0010895)2.56599594
84Abnormality of serine family amino acid metabolism (HP:0010894)2.56599594
85Autoamputation (HP:0001218)2.56522324
86Short humerus (HP:0005792)2.52334744
87Popliteal pterygium (HP:0009756)2.52092765
88Hypercalciuria (HP:0002150)2.52018593
89Nasal polyposis (HP:0100582)2.49263409
90Shawl scrotum (HP:0000049)2.49255070
91Aplasia/hypoplasia of the humerus (HP:0006507)2.48252904
92Abnormality of the labia majora (HP:0012881)2.46038103
93Hyponatremia (HP:0002902)2.43655190
94Anomalous pulmonary venous return (HP:0010772)2.43035833
95Blepharitis (HP:0000498)2.42873935
96Multifactorial inheritance (HP:0001426)2.42626521
97Vaginal fistula (HP:0004320)2.39844573
98Acanthosis nigricans (HP:0000956)2.38070970
99Partial duplication of the phalanx of hand (HP:0009999)2.37726332
100Aplasia/Hypoplasia of the fovea (HP:0008060)2.36427819
101Hypoplasia of the fovea (HP:0007750)2.36427819
102Abnormality of purine metabolism (HP:0004352)2.36054761
103Pruritus (HP:0000989)2.35307635
104Hypokalemia (HP:0002900)2.33986372
105Lack of skin elasticity (HP:0100679)2.33109972
106Keratoconjunctivitis sicca (HP:0001097)2.31203498
107Milia (HP:0001056)2.31137910
108Abnormality of sodium homeostasis (HP:0010931)2.30713028
109Abnormality of the salivary glands (HP:0010286)2.30152329
110Impulsivity (HP:0100710)2.29408468
111Fused cervical vertebrae (HP:0002949)2.27961048
112Intestinal fistula (HP:0100819)2.27882714
113Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25558423
114Hand muscle atrophy (HP:0009130)2.22559647
115Horizontal nystagmus (HP:0000666)2.21876794
116Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.17665994
117Abnormality of the astrocytes (HP:0100707)2.15302507
118Astrocytoma (HP:0009592)2.15302507
119Ridged nail (HP:0001807)2.15044593
120Abnormality of the nasal mucosa (HP:0000433)2.13492412
121Recurrent corneal erosions (HP:0000495)2.10853794
122Keratoconjunctivitis (HP:0001096)2.07399103
123Abnormality of the phalanges of the hallux (HP:0010057)2.05707230
124Trismus (HP:0000211)2.05571920
125Neoplasm of the heart (HP:0100544)2.05295071
126Pili torti (HP:0003777)2.04324421
127Abnormality of potassium homeostasis (HP:0011042)2.03420906
128Spastic tetraparesis (HP:0001285)2.01984126
129Abnormal lung lobation (HP:0002101)2.01338160
130Abnormality of the pulmonary veins (HP:0011718)2.00597589
131Tetraplegia (HP:0002445)2.00261813
132Oral leukoplakia (HP:0002745)14.7855039
133Abnormality of nail color (HP:0100643)10.2986713
134Hypergammaglobulinemia (HP:0010702)1.97467608
135Delayed epiphyseal ossification (HP:0002663)1.96966750
136Ketoacidosis (HP:0001993)1.96517707
137Sensory axonal neuropathy (HP:0003390)1.95739767
138Lymphangioma (HP:0100764)1.95005587
139Facial cleft (HP:0002006)1.92644392
140Generalized hypotonia (HP:0001290)1.90825880
141Metaphyseal cupping (HP:0003021)1.90587904
142Periauricular skin pits (HP:0100277)1.90227582
143Preauricular pit (HP:0004467)1.90227582
144Abnormality of the fovea (HP:0000493)1.89653708
145Progressive muscle weakness (HP:0003323)1.89341093
146Difficulty running (HP:0009046)1.88650002
147Oligodontia (HP:0000677)1.88159057
148Abnormal hair laboratory examination (HP:0003328)1.87665819
149Recurrent bacterial skin infections (HP:0005406)1.87471062
150Abnormality of glycolysis (HP:0004366)1.87001965
151Increased serum pyruvate (HP:0003542)1.87001965
152Preauricular skin tag (HP:0000384)1.86754742
153Follicular hyperkeratosis (HP:0007502)1.86120677
154Tongue fasciculations (HP:0001308)1.84889853
155Abnormality of small intestinal villus morphology (HP:0011472)1.84638265
156Villous atrophy (HP:0011473)1.84638265
157Pendular nystagmus (HP:0012043)1.84068480
158Abnormality of the musculature of the hand (HP:0001421)1.83433124
159Distal lower limb muscle weakness (HP:0009053)1.83410841
160Hypopigmentation of the fundus (HP:0007894)1.83376077
161Hyperhidrosis (HP:0000975)1.80164453
162Sepsis (HP:0100806)1.80161066
163Dry skin (HP:0000958)1.76983121
164Labial hypoplasia (HP:0000066)1.74803742
165Fine hair (HP:0002213)1.71177483
166Hypoplastic toenails (HP:0001800)1.69174640
167Anonychia (HP:0001798)1.68571385
168Hyperkalemia (HP:0002153)1.68473813
169Axonal loss (HP:0003447)1.67915763
170Natal tooth (HP:0000695)1.66708476
171Advanced eruption of teeth (HP:0006288)1.63777194
172Skin ulcer (HP:0200042)1.63269464
173Hypoplastic female external genitalia (HP:0012815)1.59629377
174Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.55344780
175Seborrheic dermatitis (HP:0001051)1.54009825
176Laryngomalacia (HP:0001601)1.52856730
177Corneal dystrophy (HP:0001131)1.51497756
178Skin pits (HP:0100276)1.48753572
179Melanocytic nevus (HP:0000995)1.48394986
180Verrucae (HP:0200043)1.48207517
181Papilloma (HP:0012740)1.48207517
182Elbow flexion contracture (HP:0002987)1.47257244
183Abnormality of the distal phalanges of the toes (HP:0010182)1.46128275
184Slow-growing hair (HP:0002217)1.45442915
185Abnormality of hair growth rate (HP:0011363)1.45442915
186Xerostomia (HP:0000217)1.43731729
187Abnormality of the fingernails (HP:0001231)1.39658886
188Carious teeth (HP:0000670)1.39569423
189Squamous cell carcinoma (HP:0002860)1.39089350
190Curly hair (HP:0002212)1.37929478
191Coarse hair (HP:0002208)1.37012498
192Cystic hygroma (HP:0000476)1.33520616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.97572489
2GRK54.88419645
3MAP3K34.80977496
4ERN14.16445555
5GRK64.15595496
6WNK44.08683990
7MAP3K23.99241612
8MAPKAPK33.72717669
9WNK33.53395444
10MAP3K63.25970380
11OXSR13.14354061
12GRK12.98529611
13ADRBK22.86354815
14WNK12.70309420
15IRAK32.63503354
16TGFBR22.52235843
17STK242.51844695
18TYRO32.45958318
19CSF1R2.40413590
20BLK2.31088894
21FER2.26180323
22TTK2.22036541
23STK392.08733419
24ERBB32.03245753
25TRPM72.02011506
26MATK2.00587537
27PDK41.99475043
28PDK31.99475043
29STK101.97641226
30GRK71.97319082
31MAPK71.94930545
32TAOK11.82197763
33TGFBR11.80943820
34MST1R1.74339107
35MOS1.58064893
36PIM21.47738836
37NTRK11.45962117
38NME21.45667267
39FGR1.37942063
40PDK21.37778579
41PAK41.28372908
42TBK11.25268118
43RPS6KB21.25259352
44PRKG21.23716674
45IKBKB1.22580506
46NME11.22556035
47CAMK41.22058926
48EPHA31.14655677
49EPHB21.14303169
50MARK21.11484216
51CDK71.05592509
52IRAK11.04527363
53PBK1.02003474
54STK381.01016293
55TRIB30.99189809
56JAK30.98775986
57IKBKE0.94634210
58ADRBK10.94305283
59AKT30.91820790
60TAOK20.91726110
61MAP3K10.90694747
62EPHA20.90231652
63STK38L0.90108437
64MAP2K40.89848012
65IRAK40.89488121
66CHEK20.89337051
67DMPK0.86981680
68MAP3K140.84685115
69CDC42BPA0.84297045
70BMPR20.78944637
71FGFR30.78703691
72MET0.78187706
73PRKD30.72370899
74BCKDK0.72212784
75MAP3K70.71648545
76IRAK20.71297240
77PLK10.70829756
78ICK0.70597422
79MAP2K60.69409319
80MAP3K100.69305312
81HIPK20.69244062
82ABL20.67803210
83NEK10.67163462
84AKT20.64102812
85MAP3K120.63432196
86PRPF4B0.62901218
87CSK0.60452122
88MAP3K110.59757195
89ARAF0.59586193
90EPHB10.59167841
91NEK20.58671433
92LRRK20.56926512
93PTK60.55450586
94MAPKAPK20.55276294
95MAPK120.55155475
96LATS20.55042863
97MYLK0.55024566
98MAP3K130.54625842
99PRKCI0.50537303
100CHEK10.50022004
101ZAP700.49972289
102PTK20.49016097
103KSR20.47487189
104MTOR0.47147076
105DYRK1B0.46855091
106PRKAA20.45983708
107MST40.42975881
108GSK3A0.42353243
109CHUK0.41281129
110ALK0.39991124
111LATS10.39784625
112SGK30.39763272
113FGFR10.38704152
114PRKAA10.38430046
115PRKD20.38407274
116IGF1R0.35085554
117MAP3K90.33135390
118PRKCD0.32350676
119CAMK1D0.30348549
120PDGFRB0.30246468
121MAP3K50.27587269
122ERBB20.27046825
123HCK0.26805284
124EIF2AK20.26402914
125PDGFRA0.26042552
126STK30.25640517
127AURKA0.24653567
128TESK10.23740669
129ITK0.23039508
130PRKACG0.22642526
131RIPK10.22212884
132CDK20.22055926
133PAK10.21700244
134INSR0.21229488
135PDK10.20624083
136EGFR0.20436196
137DYRK30.20429073
138CSNK1E0.20096868
139BMX0.18707876
140PRKCG0.18669436
141PIM10.18606920
142DAPK30.18565145
143PAK30.18397815
144PKN10.18142720
145PIK3CG0.17542967
146PINK10.17424700
147SGK4940.16920719
148SGK2230.16920719
149TYK20.16514435
150MAPK100.13499610
151PRKACA0.13012145
152PRKACB0.11526991
153MAPK40.10333551
154CDK40.10112224
155DDR20.07931165
156ATM0.07116691
157GSK3B0.06661050
158CDK10.06628033
159RPS6KA30.06221657
160AURKB0.06219023
161DYRK1A0.05715330
162LMTK20.05569721
163MAPK10.05411210
164SIK10.05107228
165CDK150.05032330

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.74875558
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.82792473
3Fructose and mannose metabolism_Homo sapiens_hsa000513.62969341
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.33657022
5Pentose and glucuronate interconversions_Homo sapiens_hsa000403.20594946
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63371802
7Arachidonic acid metabolism_Homo sapiens_hsa005902.62638681
8Amoebiasis_Homo sapiens_hsa051462.43555028
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.26224382
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.17206547
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.14503952
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.08303829
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.04515259
14Tryptophan metabolism_Homo sapiens_hsa003802.04444973
15Pertussis_Homo sapiens_hsa051332.04182690
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.01749683
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00496000
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.98633927
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.96059742
20Galactose metabolism_Homo sapiens_hsa000521.95608313
21Sphingolipid metabolism_Homo sapiens_hsa006001.90616113
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.87187862
23Butanoate metabolism_Homo sapiens_hsa006501.85650984
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84236479
25Propanoate metabolism_Homo sapiens_hsa006401.82913036
26VEGF signaling pathway_Homo sapiens_hsa043701.81620410
27GnRH signaling pathway_Homo sapiens_hsa049121.67178776
28Malaria_Homo sapiens_hsa051441.66275589
29Linoleic acid metabolism_Homo sapiens_hsa005911.64184714
30Carbon metabolism_Homo sapiens_hsa012001.62482296
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62038014
32TNF signaling pathway_Homo sapiens_hsa046681.61098539
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60541307
34Other glycan degradation_Homo sapiens_hsa005111.60037006
35Phenylalanine metabolism_Homo sapiens_hsa003601.59932994
36Pyruvate metabolism_Homo sapiens_hsa006201.59875936
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54214334
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49783693
39Histidine metabolism_Homo sapiens_hsa003401.47604365
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.45642789
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44320696
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44299433
43Glutathione metabolism_Homo sapiens_hsa004801.43662083
44Salmonella infection_Homo sapiens_hsa051321.42442484
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40347358
46Acute myeloid leukemia_Homo sapiens_hsa052211.36296532
47Influenza A_Homo sapiens_hsa051641.33934809
48Tuberculosis_Homo sapiens_hsa051521.28397244
49Fatty acid degradation_Homo sapiens_hsa000711.25752674
50Hepatitis C_Homo sapiens_hsa051601.22866533
51Collecting duct acid secretion_Homo sapiens_hsa049661.22507980
52Circadian rhythm_Homo sapiens_hsa047101.21684621
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19595814
54Bile secretion_Homo sapiens_hsa049761.19020456
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.18760169
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17909112
57Chemical carcinogenesis_Homo sapiens_hsa052041.14075492
58Pentose phosphate pathway_Homo sapiens_hsa000301.13938827
59Peroxisome_Homo sapiens_hsa041461.12136025
60Protein digestion and absorption_Homo sapiens_hsa049741.11204328
61Rheumatoid arthritis_Homo sapiens_hsa053231.11174218
62Vitamin digestion and absorption_Homo sapiens_hsa049771.10950824
63PPAR signaling pathway_Homo sapiens_hsa033201.07936288
64Shigellosis_Homo sapiens_hsa051311.07895959
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05936991
66Osteoclast differentiation_Homo sapiens_hsa043801.04150006
67Sphingolipid signaling pathway_Homo sapiens_hsa040711.03662861
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03260753
69Staphylococcus aureus infection_Homo sapiens_hsa051501.03004967
70Glycerolipid metabolism_Homo sapiens_hsa005611.02903632
71Biosynthesis of amino acids_Homo sapiens_hsa012301.01855994
72Notch signaling pathway_Homo sapiens_hsa043301.01140974
73Tyrosine metabolism_Homo sapiens_hsa003500.99501481
74Leishmaniasis_Homo sapiens_hsa051400.99399592
75Folate biosynthesis_Homo sapiens_hsa007900.98930135
76Selenocompound metabolism_Homo sapiens_hsa004500.98394367
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97113483
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95778240
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94729131
80Toxoplasmosis_Homo sapiens_hsa051450.93124245
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91476990
82Fatty acid metabolism_Homo sapiens_hsa012120.85745387
83Renin secretion_Homo sapiens_hsa049240.84351530
84Inositol phosphate metabolism_Homo sapiens_hsa005620.84098136
85mTOR signaling pathway_Homo sapiens_hsa041500.83841851
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.83258612
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83025212
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82185853
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82129981
90Endocytosis_Homo sapiens_hsa041440.82119185
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.81384021
92Legionellosis_Homo sapiens_hsa051340.80857880
93Lysine degradation_Homo sapiens_hsa003100.80103764
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78348997
95Mineral absorption_Homo sapiens_hsa049780.77501246
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77034917
97Prion diseases_Homo sapiens_hsa050200.76968043
98Renin-angiotensin system_Homo sapiens_hsa046140.76681349
99HIF-1 signaling pathway_Homo sapiens_hsa040660.73736117
100beta-Alanine metabolism_Homo sapiens_hsa004100.73491664
101Insulin signaling pathway_Homo sapiens_hsa049100.71504498
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70294050
103p53 signaling pathway_Homo sapiens_hsa041150.70216628
104Adherens junction_Homo sapiens_hsa045200.69526846
105Thyroid cancer_Homo sapiens_hsa052160.67440503
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.66999682
107Ras signaling pathway_Homo sapiens_hsa040140.64533926
108Salivary secretion_Homo sapiens_hsa049700.63692916
109Hedgehog signaling pathway_Homo sapiens_hsa043400.63591288
110Dorso-ventral axis formation_Homo sapiens_hsa043200.61359227
111Sulfur relay system_Homo sapiens_hsa041220.60735813
112Tight junction_Homo sapiens_hsa045300.59738912
113Choline metabolism in cancer_Homo sapiens_hsa052310.59451705
114Starch and sucrose metabolism_Homo sapiens_hsa005000.59450164
115Ovarian steroidogenesis_Homo sapiens_hsa049130.58376561
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.56940226
117Ether lipid metabolism_Homo sapiens_hsa005650.56926850
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.56563048
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.55369181
120Arginine and proline metabolism_Homo sapiens_hsa003300.55028223
121Asthma_Homo sapiens_hsa053100.53419260
122Metabolic pathways_Homo sapiens_hsa011000.53183854
123RNA transport_Homo sapiens_hsa030130.51545445
124ErbB signaling pathway_Homo sapiens_hsa040120.50163212
125MicroRNAs in cancer_Homo sapiens_hsa052060.49562525
126Nitrogen metabolism_Homo sapiens_hsa009100.49457509
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49337960
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49119763
129Pancreatic cancer_Homo sapiens_hsa052120.48366521
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48030809
131Proteoglycans in cancer_Homo sapiens_hsa052050.47715580
132Renal cell carcinoma_Homo sapiens_hsa052110.46810424
133Allograft rejection_Homo sapiens_hsa053300.46066165
134Chronic myeloid leukemia_Homo sapiens_hsa052200.45562887
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45490246
136Herpes simplex infection_Homo sapiens_hsa051680.42684874
137Sulfur metabolism_Homo sapiens_hsa009200.42377299
138mRNA surveillance pathway_Homo sapiens_hsa030150.41917314
139Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41518925
140Prolactin signaling pathway_Homo sapiens_hsa049170.40790291
141Glioma_Homo sapiens_hsa052140.40574098
142MAPK signaling pathway_Homo sapiens_hsa040100.40553266
143Long-term depression_Homo sapiens_hsa047300.40535426
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39383973
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.39257937
146Basal cell carcinoma_Homo sapiens_hsa052170.39098647
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37185899
148Apoptosis_Homo sapiens_hsa042100.36107323
149Hematopoietic cell lineage_Homo sapiens_hsa046400.35746097
150Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35712341
151AMPK signaling pathway_Homo sapiens_hsa041520.35648107
152Regulation of autophagy_Homo sapiens_hsa041400.34053409
153Fanconi anemia pathway_Homo sapiens_hsa034600.34032952
154Arginine biosynthesis_Homo sapiens_hsa002200.33819983
155One carbon pool by folate_Homo sapiens_hsa006700.29390511
156Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29135007
157Bladder cancer_Homo sapiens_hsa052190.28510255
158Retinol metabolism_Homo sapiens_hsa008300.28286716
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27622875
160Rap1 signaling pathway_Homo sapiens_hsa040150.23873932
161Thyroid hormone synthesis_Homo sapiens_hsa049180.22405562
162Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22280318
163Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20502447
164Adipocytokine signaling pathway_Homo sapiens_hsa049200.18696087
165Pathways in cancer_Homo sapiens_hsa052000.18417665
166Steroid hormone biosynthesis_Homo sapiens_hsa001400.17771442
167Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16110537
168Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15810391
169African trypanosomiasis_Homo sapiens_hsa051430.15474140
170Lysosome_Homo sapiens_hsa041420.15447692
171Cardiac muscle contraction_Homo sapiens_hsa042600.14362060
172Taste transduction_Homo sapiens_hsa047420.14265605

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