RHEB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.46602342
2ATP synthesis coupled proton transport (GO:0015986)5.08486800
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.08486800
4proteasome assembly (GO:0043248)4.77918993
5establishment of integrated proviral latency (GO:0075713)4.74251472
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.63944957
7DNA deamination (GO:0045006)4.57688325
8negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.56055798
9protein maturation by protein folding (GO:0022417)4.50410470
10cullin deneddylation (GO:0010388)4.47282743
11protein deneddylation (GO:0000338)4.44988141
12respiratory electron transport chain (GO:0022904)4.42868188
13electron transport chain (GO:0022900)4.33060545
14deoxyribose phosphate biosynthetic process (GO:0046385)4.32969525
152-deoxyribonucleotide biosynthetic process (GO:0009265)4.32969525
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.17536294
17establishment of viral latency (GO:0019043)4.00422964
18mitotic metaphase plate congression (GO:0007080)3.87648656
19regulation of mitotic spindle organization (GO:0060236)3.87632955
20chaperone-mediated protein transport (GO:0072321)3.82053246
21nucleobase-containing small molecule interconversion (GO:0015949)3.66967658
22L-serine metabolic process (GO:0006563)3.66347028
23establishment of protein localization to mitochondrion (GO:0072655)3.56449844
24protein targeting to mitochondrion (GO:0006626)3.56014470
25regulation of mitochondrial translation (GO:0070129)3.54712928
26protein localization to mitochondrion (GO:0070585)3.52335153
27deoxyribonucleotide biosynthetic process (GO:0009263)3.51572534
28mitotic sister chromatid segregation (GO:0000070)3.50638156
29protein neddylation (GO:0045116)3.48149166
30protein complex biogenesis (GO:0070271)3.43616344
31DNA unwinding involved in DNA replication (GO:0006268)3.41768401
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.41353971
33nuclear envelope reassembly (GO:0031468)3.39422697
34mitotic nuclear envelope reassembly (GO:0007084)3.39422697
35telomere maintenance via semi-conservative replication (GO:0032201)3.36544619
36Golgi transport vesicle coating (GO:0048200)3.31091800
37COPI coating of Golgi vesicle (GO:0048205)3.31091800
38deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.30656957
39DNA strand elongation involved in DNA replication (GO:0006271)3.30319955
40oxidative phosphorylation (GO:0006119)3.29804228
41regulation of spindle organization (GO:0090224)3.27714745
42ribosomal large subunit biogenesis (GO:0042273)3.27433087
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24183431
44metaphase plate congression (GO:0051310)3.23805513
45DNA strand elongation (GO:0022616)3.22093268
46synaptic vesicle exocytosis (GO:0016079)3.20734237
47mitochondrial respiratory chain complex assembly (GO:0033108)3.19570549
48CENP-A containing nucleosome assembly (GO:0034080)3.19423618
49mitotic chromosome condensation (GO:0007076)3.19239226
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.17826362
51NADH dehydrogenase complex assembly (GO:0010257)3.17826362
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17826362
53regulation of cellular amino acid metabolic process (GO:0006521)3.11748458
54chromatin remodeling at centromere (GO:0031055)3.10030958
55protein localization to chromosome, centromeric region (GO:0071459)3.10001988
56guanosine-containing compound biosynthetic process (GO:1901070)3.09484965
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.08928768
58sister chromatid segregation (GO:0000819)3.07494076
59negative regulation of cation channel activity (GO:2001258)3.05445692
60GTP biosynthetic process (GO:0006183)3.05178812
61membrane budding (GO:0006900)3.04264026
62protein retention in ER lumen (GO:0006621)2.99880744
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99795722
64positive regulation of vesicle fusion (GO:0031340)2.98900508
65purine nucleobase biosynthetic process (GO:0009113)2.98664857
66maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.91997510
67regulation of ubiquitin-protein transferase activity (GO:0051438)2.91911245
68de novo protein folding (GO:0006458)2.89784667
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89541416
70negative regulation of ligase activity (GO:0051352)2.89541416
71ribosome assembly (GO:0042255)2.89369016
72inner mitochondrial membrane organization (GO:0007007)2.87627663
73regulation of synaptic vesicle exocytosis (GO:2000300)2.86968164
74GDP-mannose metabolic process (GO:0019673)2.86747754
75protein localization to kinetochore (GO:0034501)2.85698358
76regulation of vesicle fusion (GO:0031338)2.85234268
77negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.84819494
78negative regulation of calcium ion transmembrane transport (GO:1903170)2.84819494
79regulation of synaptic vesicle transport (GO:1902803)2.83858308
80negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.83783478
81negative regulation of microtubule polymerization (GO:0031115)2.82815083
82RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81927277
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81927277
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81802630
85ATP hydrolysis coupled proton transport (GO:0015991)2.81334120
86energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.81334120
87protein complex localization (GO:0031503)2.81279919
88formation of translation preinitiation complex (GO:0001731)2.80629204
89ribonucleoprotein complex disassembly (GO:0032988)2.80497762
90cellular protein complex localization (GO:0034629)2.79553078
91regulation of ligase activity (GO:0051340)2.78235634
92positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.77593634
93ventricular cardiac muscle cell development (GO:0055015)2.76286499
94lipopolysaccharide biosynthetic process (GO:0009103)2.75529118
95respiratory chain complex IV assembly (GO:0008535)2.73783976
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73211003
97protein peptidyl-prolyl isomerization (GO:0000413)2.72969830
98antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.71707591
99pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.70251736
100regulation of protein heterodimerization activity (GO:0043497)2.69392468
101neuronal action potential propagation (GO:0019227)2.69140274
102positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69052623
103de novo posttranslational protein folding (GO:0051084)2.67016031
104DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.66642139
105DNA replication checkpoint (GO:0000076)2.66613871
106positive regulation of ligase activity (GO:0051351)2.65362872
107ribosomal small subunit biogenesis (GO:0042274)2.63388811
108glutamate secretion (GO:0014047)2.62242431
109mitochondrial transport (GO:0006839)2.61993357
110hydrogen ion transmembrane transport (GO:1902600)2.61944319
111negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.60008494
112intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.59739584
113signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.59739584
114cytochrome complex assembly (GO:0017004)2.59736564
115positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.59566653
116establishment of chromosome localization (GO:0051303)2.58902331
117regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.58541950
118signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.57755793
119signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.57755793
120signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.57755793
121IMP biosynthetic process (GO:0006188)2.57313931
122regulation of cofactor metabolic process (GO:0051193)2.56509776
123regulation of coenzyme metabolic process (GO:0051196)2.56509776
124negative regulation of calcium ion transport into cytosol (GO:0010523)2.54148032
125ribonucleoprotein complex biogenesis (GO:0022613)2.53769655
126CTP metabolic process (GO:0046036)2.53305203
127CTP biosynthetic process (GO:0006241)2.53305203
128telomere maintenance via recombination (GO:0000722)2.52615865
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.52103041
130positive regulation of mitochondrial fission (GO:0090141)2.51856857
131antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.51524341
132maturation of SSU-rRNA (GO:0030490)2.48539330
133positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.47891533
134protein heterotetramerization (GO:0051290)2.47687760
135tRNA aminoacylation for protein translation (GO:0006418)2.47100381
136kinetochore organization (GO:0051383)2.46218124
137G1/S transition of mitotic cell cycle (GO:0000082)2.45952715
138cell cycle G1/S phase transition (GO:0044843)2.45952715
139negative regulation of dendrite morphogenesis (GO:0050774)2.45824963
140regulation of cellular amine metabolic process (GO:0033238)2.45688707
141nucleoside diphosphate phosphorylation (GO:0006165)2.44537195
142DNA replication-independent nucleosome organization (GO:0034724)2.43684638
143DNA replication-independent nucleosome assembly (GO:0006336)2.43684638
144signal transduction involved in DNA damage checkpoint (GO:0072422)2.43377261
145signal transduction involved in DNA integrity checkpoint (GO:0072401)2.43377261
146regulation of chromosome segregation (GO:0051983)2.42776276
147transferrin transport (GO:0033572)2.42769630
148regulation of neuron projection regeneration (GO:0070570)2.42646596
149regulation of axon regeneration (GO:0048679)2.42646596
150IMP metabolic process (GO:0046040)2.42465647
151peptidyl-proline modification (GO:0018208)2.42145579
152response to misfolded protein (GO:0051788)2.42042806
153pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.41992808
154mitotic recombination (GO:0006312)2.41966663
155purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.41476430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.78938525
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.29064271
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26951908
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.75939607
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.55663144
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.43712583
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.17827890
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.07583520
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90453439
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86796731
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.80202422
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.75631326
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.67395487
14DCP1A_22483619_ChIP-Seq_HELA_Human2.65464336
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64108971
16AR_21909140_ChIP-Seq_LNCAP_Human2.62897518
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56523829
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51769704
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50553435
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50549903
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49278744
22VDR_22108803_ChIP-Seq_LS180_Human2.42002966
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.40851762
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.37468493
25ELK1_19687146_ChIP-ChIP_HELA_Human2.34601241
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30400639
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21930166
28ELK1_22589737_ChIP-Seq_MCF10A_Human2.19668817
29VDR_23849224_ChIP-Seq_CD4+_Human2.18544467
30* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15222142
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11547192
32EZH2_22144423_ChIP-Seq_EOC_Human2.09930709
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09819675
34* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.08973402
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06039743
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04353625
37IGF1R_20145208_ChIP-Seq_DFB_Human2.03877195
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.95436283
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95294538
40TTF2_22483619_ChIP-Seq_HELA_Human1.91575880
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.86757792
42* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.84852833
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84517512
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76440733
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76254108
46GABP_19822575_ChIP-Seq_HepG2_Human1.76058717
47* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.75817626
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68879699
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67956994
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67829909
51XRN2_22483619_ChIP-Seq_HELA_Human1.64098619
52* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.60158290
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.59212044
54* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.57589939
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52744280
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51328959
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51187637
58FUS_26573619_Chip-Seq_HEK293_Human1.49566253
59ZNF263_19887448_ChIP-Seq_K562_Human1.46607946
60ZNF274_21170338_ChIP-Seq_K562_Hela1.46385514
61CLOCK_20551151_ChIP-Seq_293T_Human1.45609615
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45363867
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45194092
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44960262
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43196004
66* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39051403
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38107166
68* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36581927
69* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33516965
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.33042685
71JUN_21703547_ChIP-Seq_K562_Human1.32107437
72GBX2_23144817_ChIP-Seq_PC3_Human1.32008358
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30807033
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30339024
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29807521
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28064442
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27709263
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26722779
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25650079
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25277748
81REST_19997604_ChIP-ChIP_NEURONS_Mouse1.24998044
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24221008
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23129183
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.23109773
85* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22999369
86FOXP3_21729870_ChIP-Seq_TREG_Human1.22643427
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22494860
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.21161084
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20530810
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19796260
91JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19508423
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18594338
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18106285
94MYC_18940864_ChIP-ChIP_HL60_Human1.17913341
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17379306
96SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17027665
97SOX17_20123909_ChIP-Seq_XEN_Mouse1.16751012
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15799594
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13548362
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13093816
101SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12913337
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12054565
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.11861847
104* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11340938
105SOX2_18692474_ChIP-Seq_MEFs_Mouse1.11273247
106ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10050638
107* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10043445
108TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09653076
109EWS_26573619_Chip-Seq_HEK293_Human1.08491371
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08487611
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07452236
112ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06461884
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06437235
114KDM5A_27292631_Chip-Seq_BREAST_Human1.06000801
115RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05441514
116* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.05391605
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05390611
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05129238
119WT1_19549856_ChIP-ChIP_CCG9911_Human1.04276964
120* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03401055
121STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03228860
122OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03055429
123P300_19829295_ChIP-Seq_ESCs_Human1.02884552
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02291591
125CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01988121
126TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01886171
127NOTCH1_21737748_ChIP-Seq_TLL_Human1.01814097
128REST_21632747_ChIP-Seq_MESCs_Mouse1.01123399
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99242152
130HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99233190
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98545104
132HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97136776
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96965773
134CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96593733
135HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95777644
136EED_16625203_ChIP-ChIP_MESCs_Mouse0.95704648
137SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95197249
138* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94009094
139TP53_22573176_ChIP-Seq_HFKS_Human0.92991204
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90488442
141ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90310697
142SMAD_19615063_ChIP-ChIP_OVARY_Human0.88838050
143EZH2_27304074_Chip-Seq_ESCs_Mouse0.88706062
144* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88424535
145TFEB_21752829_ChIP-Seq_HELA_Human0.86369506
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86366149
147MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81604789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.46899605
2MP0006276_abnormal_autonomic_nervous3.40183166
3MP0002735_abnormal_chemical_nociception3.05264103
4MP0003111_abnormal_nucleus_morphology2.97983023
5MP0004859_abnormal_synaptic_plasticity2.91279999
6MP0001968_abnormal_touch/_nociception2.85730215
7MP0009379_abnormal_foot_pigmentation2.83801635
8MP0001188_hyperpigmentation2.76480638
9MP0010094_abnormal_chromosome_stability2.66254480
10MP0000013_abnormal_adipose_tissue2.56534121
11MP0004270_analgesia2.53055537
12MP0002736_abnormal_nociception_after2.50787027
13MP0003077_abnormal_cell_cycle2.48272049
14MP0003806_abnormal_nucleotide_metabolis2.44708092
15MP0002734_abnormal_mechanical_nocicepti2.38334533
16MP0008007_abnormal_cellular_replicative2.37287874
17MP0010386_abnormal_urinary_bladder2.30874064
18MP0002733_abnormal_thermal_nociception2.18990519
19MP0005623_abnormal_meninges_morphology2.17154708
20MP0002638_abnormal_pupillary_reflex2.10546133
21MP0001905_abnormal_dopamine_level2.07460214
22MP0008058_abnormal_DNA_repair2.06185713
23MP0004858_abnormal_nervous_system2.05764243
24MP0003635_abnormal_synaptic_transmissio2.05216589
25MP0001970_abnormal_pain_threshold2.03762363
26MP0001986_abnormal_taste_sensitivity1.98703716
27MP0005058_abnormal_lysosome_morphology1.98628652
28MP0001501_abnormal_sleep_pattern1.96787523
29MP0001440_abnormal_grooming_behavior1.96642740
30MP0003693_abnormal_embryo_hatching1.89121921
31MP0009745_abnormal_behavioral_response1.79099721
32MP0002234_abnormal_pharynx_morphology1.78602446
33MP0003123_paternal_imprinting1.76371876
34MP0002063_abnormal_learning/memory/cond1.73698437
35MP0010030_abnormal_orbit_morphology1.68299721
36MP0001542_abnormal_bone_strength1.66907519
37MP0002909_abnormal_adrenal_gland1.66374066
38MP0005084_abnormal_gallbladder_morpholo1.65123398
39MP0000750_abnormal_muscle_regeneration1.62784557
40MP0001730_embryonic_growth_arrest1.58614093
41MP0004145_abnormal_muscle_electrophysio1.57137495
42MP0002184_abnormal_innervation1.54991615
43MP0000749_muscle_degeneration1.54156529
44MP0002837_dystrophic_cardiac_calcinosis1.52445347
45MP0003646_muscle_fatigue1.50616340
46MP0002090_abnormal_vision1.47923782
47MP0004215_abnormal_myocardial_fiber1.47859408
48MP0002067_abnormal_sensory_capabilities1.47816212
49MP0001529_abnormal_vocalization1.46605436
50MP0000350_abnormal_cell_proliferation1.46044309
51MP0006036_abnormal_mitochondrial_physio1.44320234
52MP0009046_muscle_twitch1.43849590
53MP0002572_abnormal_emotion/affect_behav1.42855929
54MP0002064_seizures1.42775429
55MP0000647_abnormal_sebaceous_gland1.42126259
56MP0003279_aneurysm1.41495109
57MP0005257_abnormal_intraocular_pressure1.41058235
58MP0004272_abnormal_basement_membrane1.36617166
59MP0003329_amyloid_beta_deposits1.35699889
60MP0006292_abnormal_olfactory_placode1.35425117
61MP0003718_maternal_effect1.34782366
62MP0002272_abnormal_nervous_system1.33430267
63MP0006035_abnormal_mitochondrial_morpho1.32021697
64MP0004233_abnormal_muscle_weight1.26384547
65MP0004142_abnormal_muscle_tone1.24989762
66MP0002751_abnormal_autonomic_nervous1.24759372
67MP0002332_abnormal_exercise_endurance1.23583626
68MP0005386_behavior/neurological_phenoty1.22852765
69MP0004924_abnormal_behavior1.22852765
70MP0004484_altered_response_of1.21710247
71MP0000681_abnormal_thyroid_gland1.17974611
72MP0001697_abnormal_embryo_size1.16256967
73MP0004957_abnormal_blastocyst_morpholog1.15897340
74MP0003566_abnormal_cell_adhesion1.12234969
75MP0001299_abnormal_eye_distance/1.10529592
76MP0002697_abnormal_eye_size1.09861669
77MP0000358_abnormal_cell_content/1.09327501
78MP0005535_abnormal_body_temperature1.09138623
79MP0005165_increased_susceptibility_to1.08836104
80MP0002080_prenatal_lethality1.08830308
81MP0005501_abnormal_skin_physiology1.07830838
82MP0001502_abnormal_circadian_rhythm1.07824627
83MP0009697_abnormal_copulation1.06886935
84MP0000747_muscle_weakness1.04958010
85MP0008789_abnormal_olfactory_epithelium1.04877408
86MP0005503_abnormal_tendon_morphology1.03626734
87MP0000537_abnormal_urethra_morphology1.03438183
88MP0000751_myopathy1.02342273
89MP0004811_abnormal_neuron_physiology1.02027629
90MP0003950_abnormal_plasma_membrane1.01807953
91MP0003941_abnormal_skin_development1.00871887
92MP0008932_abnormal_embryonic_tissue1.00709628
93MP0000372_irregular_coat_pigmentation1.00672851
94MP0001984_abnormal_olfaction1.00526837
95MP0003879_abnormal_hair_cell0.99704187
96MP0003786_premature_aging0.97505452
97MP0001672_abnormal_embryogenesis/_devel0.96258645
98MP0005380_embryogenesis_phenotype0.96258645
99MP0003136_yellow_coat_color0.95459905
100MP0004510_myositis0.94672543
101MP0005187_abnormal_penis_morphology0.92981417
102MP0002693_abnormal_pancreas_physiology0.92555942
103MP0003186_abnormal_redox_activity0.92552769
104MP0008260_abnormal_autophagy0.92125089
105MP0003656_abnormal_erythrocyte_physiolo0.91574978
106MP0003195_calcinosis0.91413973
107MP0000313_abnormal_cell_death0.89630420
108MP0005384_cellular_phenotype0.88988283
109MP0002085_abnormal_embryonic_tissue0.88528100
110MP0001727_abnormal_embryo_implantation0.88304727
111MP0005197_abnormal_uvea_morphology0.86829559
112MP0002269_muscular_atrophy0.86511559
113MP0003221_abnormal_cardiomyocyte_apopto0.86020057
114MP0002092_abnormal_eye_morphology0.85683607
115MP0005330_cardiomyopathy0.85174971
116MP0003122_maternal_imprinting0.84904877
117MP0006072_abnormal_retinal_apoptosis0.84869089
118MP0003937_abnormal_limbs/digits/tail_de0.84477444
119MP0002972_abnormal_cardiac_muscle0.83447602
120MP0009053_abnormal_anal_canal0.83390734
121MP0004147_increased_porphyrin_level0.82082358
122MP0003385_abnormal_body_wall0.82076370
123MP0009840_abnormal_foam_cell0.82046398
124MP0005379_endocrine/exocrine_gland_phen0.81373045
125MP0005620_abnormal_muscle_contractility0.80173401
126MP0005499_abnormal_olfactory_system0.79546250
127MP0005394_taste/olfaction_phenotype0.79546250
128MP0002084_abnormal_developmental_patter0.79264183
129MP0005171_absent_coat_pigmentation0.79171752
130MP0005275_abnormal_skin_tensile0.79070742
131MP0001853_heart_inflammation0.78958282
132MP0000343_altered_response_to0.77853218
133MP0001293_anophthalmia0.77678142
134MP0005595_abnormal_vascular_smooth0.77620357
135MP0001348_abnormal_lacrimal_gland0.77140868
136MP0005451_abnormal_body_composition0.76942215
137MP0002160_abnormal_reproductive_system0.75937126
138MP0001919_abnormal_reproductive_system0.75924239
139MP0005164_abnormal_response_to0.75319240
140MP0002557_abnormal_social/conspecific_i0.75022121
141MP0003984_embryonic_growth_retardation0.74968445
142MP0002177_abnormal_outer_ear0.74921445
143MP0003634_abnormal_glial_cell0.74110521
144MP0000759_abnormal_skeletal_muscle0.73995462
145MP0010352_gastrointestinal_tract_polyps0.73912371
146MP0002066_abnormal_motor_capabilities/c0.73839686
147MP0003137_abnormal_impulse_conducting0.73211353
148MP0008438_abnormal_cutaneous_collagen0.73067311
149MP0000955_abnormal_spinal_cord0.72943593
150MP0003705_abnormal_hypodermis_morpholog0.72900659
151MP0001881_abnormal_mammary_gland0.72743730
152MP0009672_abnormal_birth_weight0.71725056
153MP0002938_white_spotting0.71697283
154MP0002106_abnormal_muscle_physiology0.71179518
155MP0003315_abnormal_perineum_morphology0.70869524
156MP0002877_abnormal_melanocyte_morpholog0.70842047
157MP0002233_abnormal_nose_morphology0.70644235
158MP0005645_abnormal_hypothalamus_physiol0.70320261
159MP0005248_abnormal_Harderian_gland0.69818207
160MP0005621_abnormal_cell_physiology0.69731074
161MP0003453_abnormal_keratinocyte_physiol0.68904747
162MP0001486_abnormal_startle_reflex0.68887924
163MP0008775_abnormal_heart_ventricle0.68279300
164MP0000538_abnormal_urinary_bladder0.67710139
165MP0001664_abnormal_digestion0.66319842

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.98481876
2Abnormal mitochondria in muscle tissue (HP:0008316)4.65322633
3Mitochondrial inheritance (HP:0001427)4.42174175
4Progressive macrocephaly (HP:0004481)4.21931763
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.16103549
6Abnormality of alanine metabolism (HP:0010916)4.16103549
7Hyperalaninemia (HP:0003348)4.16103549
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.87593452
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.87593452
10Hepatocellular necrosis (HP:0001404)3.86419996
11Cortical dysplasia (HP:0002539)3.83446750
12Increased CSF lactate (HP:0002490)3.80093991
13Hepatic necrosis (HP:0002605)3.60572693
14Acute encephalopathy (HP:0006846)3.55558769
15Hypothermia (HP:0002045)3.41849260
16Visual hallucinations (HP:0002367)3.32377912
17Abnormality of the anterior horn cell (HP:0006802)3.22918627
18Degeneration of anterior horn cells (HP:0002398)3.22918627
19Neuroendocrine neoplasm (HP:0100634)3.21505784
20Pheochromocytoma (HP:0002666)3.08720009
21Increased hepatocellular lipid droplets (HP:0006565)3.02290247
22Upper limb muscle weakness (HP:0003484)2.98629319
23Dysautonomia (HP:0002459)2.96532044
24Retinal dysplasia (HP:0007973)2.95797856
25Lactic acidosis (HP:0003128)2.87460391
26Exercise intolerance (HP:0003546)2.86729181
27Abnormality of the musculature of the pelvis (HP:0001469)2.82310413
28Abnormality of the hip-girdle musculature (HP:0001445)2.82310413
29Focal motor seizures (HP:0011153)2.79234562
30Delusions (HP:0000746)2.77481807
31Respiratory failure (HP:0002878)2.71005011
32Increased serum lactate (HP:0002151)2.68683896
33Shoulder girdle muscle weakness (HP:0003547)2.66667685
34Myokymia (HP:0002411)2.66416813
35Increased intramyocellular lipid droplets (HP:0012240)2.58307702
36Delayed gross motor development (HP:0002194)2.56521161
37Lipid accumulation in hepatocytes (HP:0006561)2.56496683
38Abnormal autonomic nervous system physiology (HP:0012332)2.53024581
39Cholecystitis (HP:0001082)2.52831714
40Abnormal gallbladder physiology (HP:0012438)2.52831714
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52250152
42Absence seizures (HP:0002121)2.46828236
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46760473
44Type II lissencephaly (HP:0007260)2.45889839
45Unsteady gait (HP:0002317)2.42961049
46Vertebral compression fractures (HP:0002953)2.31035352
47Microretrognathia (HP:0000308)2.28031325
48Microvesicular hepatic steatosis (HP:0001414)2.27458752
49Emotional lability (HP:0000712)2.27021716
50Multiple enchondromatosis (HP:0005701)2.26410462
51Hypokinesia (HP:0002375)2.25619016
52Insomnia (HP:0100785)2.24666347
53Fasciculations (HP:0002380)2.24573730
54Atonic seizures (HP:0010819)2.23817775
55Renal Fanconi syndrome (HP:0001994)2.21041670
56Spastic diplegia (HP:0001264)2.18999810
57Myotonia (HP:0002486)2.17504055
58Exercise-induced muscle cramps (HP:0003710)2.16861976
59Abnormality of liposaccharide metabolism (HP:0010968)2.16579841
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.16579841
61Abnormality of glycolipid metabolism (HP:0010969)2.16579841
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14736462
63Optic disc pallor (HP:0000543)2.11924973
64Insidious onset (HP:0003587)2.10217585
65Termporal pattern (HP:0011008)2.10217585
66Ulnar claw (HP:0001178)2.09859154
67Increased serum pyruvate (HP:0003542)2.09507580
68Abnormality of glycolysis (HP:0004366)2.09507580
69Pelvic girdle muscle weakness (HP:0003749)2.09401426
70Nuclear cataract (HP:0100018)2.07463397
71Increased muscle lipid content (HP:0009058)2.06241181
72Overriding aorta (HP:0002623)2.05903946
73Exertional dyspnea (HP:0002875)2.05903801
74Reticulocytopenia (HP:0001896)2.05095774
75Cerebral hypomyelination (HP:0006808)2.04828281
76Hyperparathyroidism (HP:0000843)2.03486747
77Birth length less than 3rd percentile (HP:0003561)2.03180031
78Limb dystonia (HP:0002451)2.02702173
79Cerebral edema (HP:0002181)1.99397484
80Increased nuchal translucency (HP:0010880)1.99380066
81Postnatal microcephaly (HP:0005484)1.98211592
82Reduced antithrombin III activity (HP:0001976)1.97341449
83Dialeptic seizures (HP:0011146)1.96927495
84X-linked dominant inheritance (HP:0001423)1.96300132
85Distal lower limb amyotrophy (HP:0008944)1.96063677
86Ragged-red muscle fibers (HP:0003200)1.95072184
87Gait imbalance (HP:0002141)1.93204945
88Orthostatic hypotension (HP:0001278)1.92973142
89Type I transferrin isoform profile (HP:0003642)1.92797572
90Limb-girdle muscle atrophy (HP:0003797)1.92011909
91Anxiety (HP:0000739)1.91067325
92Abnormality of the tricuspid valve (HP:0001702)1.89597334
93Lower limb amyotrophy (HP:0007210)1.89576856
94Hypercortisolism (HP:0001578)1.88045122
95Medial flaring of the eyebrow (HP:0010747)1.87182596
96Macrocytic anemia (HP:0001972)1.86104842
97Lissencephaly (HP:0001339)1.85475157
98Myoglobinuria (HP:0002913)1.84748280
99Median cleft lip (HP:0000161)1.84075114
100Abnormal protein glycosylation (HP:0012346)1.83001153
101Abnormal glycosylation (HP:0012345)1.83001153
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83001153
103Abnormal protein N-linked glycosylation (HP:0012347)1.83001153
104Sensorimotor neuropathy (HP:0007141)1.82891172
105Epileptic encephalopathy (HP:0200134)1.82022381
106Congenital primary aphakia (HP:0007707)1.81342822
107Poor head control (HP:0002421)1.81170334
108Patent foramen ovale (HP:0001655)1.80918710
1093-Methylglutaconic aciduria (HP:0003535)1.80340149
110Amblyopia (HP:0000646)1.79235638
111Abnormality of the umbilical cord (HP:0010881)1.78796409
112Premature rupture of membranes (HP:0001788)1.76860484
113Atrophy/Degeneration involving motor neurons (HP:0007373)1.76738831
114Leukodystrophy (HP:0002415)1.76720542
115Gout (HP:0001997)1.75850194
116Abnormality of calcium-phosphate metabolism (HP:0100530)1.74957548
117Nausea (HP:0002018)1.74870800
118Progressive muscle weakness (HP:0003323)1.74771730
119CNS demyelination (HP:0007305)1.74190842
120Respiratory difficulties (HP:0002880)1.74168654
121Achilles tendon contracture (HP:0001771)1.74019626
122Agitation (HP:0000713)1.73907659
123Neoplasm of the peripheral nervous system (HP:0100007)1.73315414
124Abnormal number of erythroid precursors (HP:0012131)1.73216263
125Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.73010800
126Neuroblastoma (HP:0003006)1.70883445
127Primitive neuroectodermal tumor (HP:0030065)1.70883445
128Neuroblastic tumors (HP:0004376)1.70883445
129Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.70883445
130Spastic paraparesis (HP:0002313)1.70038029
131Hand muscle atrophy (HP:0009130)1.69461373
132Distal arthrogryposis (HP:0005684)1.68918306
133Abnormality of cells of the erythroid lineage (HP:0012130)1.68637342
134Esotropia (HP:0000565)1.68535940
135Hyperthyroidism (HP:0000836)1.68317441
136Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.66987155
137Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66802160
138Abnormality of renal resorption (HP:0011038)1.66691431
139Nephrogenic diabetes insipidus (HP:0009806)1.66183960
140Truncus arteriosus (HP:0001660)1.65500406
141Adrenal hypoplasia (HP:0000835)1.65497057
142Diminished motivation (HP:0000745)1.65370681
143Rimmed vacuoles (HP:0003805)1.65225851
144Focal seizures (HP:0007359)1.64534091
145Progressive cerebellar ataxia (HP:0002073)1.64232803
146Neoplasm of the adrenal gland (HP:0100631)1.63491801
147Nemaline bodies (HP:0003798)1.62577270
148Tetraparesis (HP:0002273)1.62390526
149Hypoventilation (HP:0002791)1.62204997
150Generalized tonic-clonic seizures (HP:0002069)1.61947704
151Failure to thrive in infancy (HP:0001531)1.61322185
152Axonal loss (HP:0003447)1.59863233
153Distal upper limb amyotrophy (HP:0007149)1.59063816
154Upper limb amyotrophy (HP:0009129)1.59063816
155Autoamputation (HP:0001218)1.57289125
156Apathy (HP:0000741)1.56195821
157Facial cleft (HP:0002006)1.56184813
158Abnormality of the motor neurons (HP:0002450)1.56043870
159Abnormal neuron morphology (HP:0012757)1.56043870
160Abnormality of the Achilles tendon (HP:0005109)1.53151189
161Hammertoe (HP:0001765)1.52925456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF3.46691025
2MAP3K123.10849297
3STK163.00115257
4BUB12.79531872
5NME12.74929118
6LIMK12.71468410
7RIPK42.55066718
8MAP3K92.44447779
9NTRK32.21443228
10MINK12.20154162
11PIM22.17193202
12NME22.17126877
13SRPK12.13121658
14CDC72.13119618
15ACVR1B2.07474989
16CAMKK22.01580477
17TTK1.98099394
18MAP3K111.93645524
19SCYL21.86956939
20RAF11.85728589
21KSR21.84670016
22LATS21.82206245
23PLK21.80162170
24MAPKAPK31.76767140
25TESK11.64488978
26MST1R1.61447276
27BMPR21.60933220
28BRAF1.60717262
29EIF2AK31.57345275
30EIF2AK11.55787342
31TRIM281.55548813
32VRK21.54070234
33MOS1.51364560
34PAK41.49538437
35NTRK11.47259919
36WEE11.45878537
37PDK21.44824508
38TESK21.41557882
39CSNK1G31.36036828
40KSR11.35377688
41GRK51.32968006
42BRSK11.32092973
43ERBB41.30257539
44VRK11.30050898
45RPS6KA41.29992848
46PLK11.25700348
47CCNB11.25495739
48MET1.24398919
49EPHA41.19401683
50CSNK1G21.18020032
51MAP2K71.16695177
52TSSK61.15425074
53BCKDK1.12028311
54DYRK21.10370054
55PNCK1.09111638
56CSNK1A1L1.08522885
57PTK21.01861708
58DAPK11.01167002
59CASK0.98383021
60MAP2K10.96612266
61CDK11A0.96367730
62ERBB30.94976690
63CSNK1G10.94230146
64MARK10.93970993
65PINK10.93137125
66MAP3K130.89483035
67ABL20.89452599
68AURKA0.88721097
69MAP3K50.88171539
70DYRK30.88054889
71MAP3K20.88017166
72AURKB0.85575882
73EPHB20.85302459
74CDK190.84850320
75BCR0.84838259
76PBK0.83469846
77MAPK150.83069215
78CHEK20.80978787
79MAP3K30.79666434
80CDK140.79336238
81PIK3CG0.79021335
82PAK10.76401138
83GRK70.75831809
84IRAK30.75461471
85PRKCG0.73444860
86PLK40.71757292
87IRAK10.71654031
88ADRBK10.67894829
89BMX0.65485475
90NEK10.65203401
91BMPR1B0.65095661
92MUSK0.64480050
93PAK60.62972743
94BRSK20.62457089
95MAPKAPK50.62002782
96CAMK2A0.60210358
97DMPK0.59996195
98EPHA20.59788169
99FER0.59006353
100DAPK30.57500094
101MAP3K80.57337674
102TNIK0.57137030
103LMTK20.55808456
104UHMK10.54701593
105MAP3K10.54695088
106PLK30.54269992
107PRKCE0.53061387
108CDK50.52582576
109MYLK0.52528569
110NEK20.51645041
111MAP2K40.50577203
112TLK10.50194313
113SIK30.50050923
114DYRK1A0.49155126
115FRK0.48963697
116PAK30.48349320
117CAMK2B0.48211121
118MAP3K60.48197055
119KDR0.47817905
120YES10.47729463
121STK38L0.46815915
122PTK2B0.46257639
123CDK70.45819481
124AKT20.44940300
125MAP3K40.44853667
126CAMK2D0.44507761
127ADRBK20.44309636
128MKNK10.44179195
129CDK180.43455305
130PRKD30.42941932
131CSNK2A10.42489572
132CAMK2G0.42152835
133PHKG20.41405254
134PHKG10.41405254
135CDK80.41363807
136MST40.41344974
137MAPK130.40896646
138CHEK10.38604595
139ATR0.38524759
140TAOK20.36500415
141CSNK2A20.35849384
142CDK150.35565826
143ILK0.35507516
144DDR20.35495263

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.18397984
2Parkinsons disease_Homo sapiens_hsa050123.61955798
3Proteasome_Homo sapiens_hsa030503.60901469
4Protein export_Homo sapiens_hsa030602.92400400
5Alzheimers disease_Homo sapiens_hsa050102.84988089
6Huntingtons disease_Homo sapiens_hsa050162.77137438
7Ribosome_Homo sapiens_hsa030102.52565414
8Fatty acid elongation_Homo sapiens_hsa000622.15975802
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13612710
10Synaptic vesicle cycle_Homo sapiens_hsa047212.09588598
11Cardiac muscle contraction_Homo sapiens_hsa042601.96141092
12Biosynthesis of amino acids_Homo sapiens_hsa012301.95753875
13Vitamin B6 metabolism_Homo sapiens_hsa007501.95221524
14Collecting duct acid secretion_Homo sapiens_hsa049661.90477953
15Vibrio cholerae infection_Homo sapiens_hsa051101.89759319
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88766716
17RNA polymerase_Homo sapiens_hsa030201.78009117
18Carbon metabolism_Homo sapiens_hsa012001.70553974
19Nicotine addiction_Homo sapiens_hsa050331.62704037
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62570881
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59308604
22Long-term potentiation_Homo sapiens_hsa047201.59186666
23Pyruvate metabolism_Homo sapiens_hsa006201.57659400
24Pentose phosphate pathway_Homo sapiens_hsa000301.52345715
25Steroid biosynthesis_Homo sapiens_hsa001001.50289950
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48754518
27Sulfur relay system_Homo sapiens_hsa041221.45092647
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.44364349
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44302808
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41438661
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39737084
32Dopaminergic synapse_Homo sapiens_hsa047281.37736292
33Serotonergic synapse_Homo sapiens_hsa047261.28950020
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28622364
35Taste transduction_Homo sapiens_hsa047421.28303363
36Amphetamine addiction_Homo sapiens_hsa050311.27698225
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25754403
38Oocyte meiosis_Homo sapiens_hsa041141.22518751
39Circadian entrainment_Homo sapiens_hsa047131.19547076
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.18520362
41Glutathione metabolism_Homo sapiens_hsa004801.17567637
42Regulation of autophagy_Homo sapiens_hsa041401.16745741
43Pyrimidine metabolism_Homo sapiens_hsa002401.14743683
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14702466
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12188559
46One carbon pool by folate_Homo sapiens_hsa006701.12134581
47Insulin secretion_Homo sapiens_hsa049111.10074219
48Long-term depression_Homo sapiens_hsa047301.08328568
49Galactose metabolism_Homo sapiens_hsa000521.07080601
50GABAergic synapse_Homo sapiens_hsa047271.02556326
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02260466
52DNA replication_Homo sapiens_hsa030301.01811222
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01160337
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00524901
55Shigellosis_Homo sapiens_hsa051310.94550133
56Circadian rhythm_Homo sapiens_hsa047100.91818193
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91619126
58Fanconi anemia pathway_Homo sapiens_hsa034600.86776365
59Gap junction_Homo sapiens_hsa045400.86744243
60Rheumatoid arthritis_Homo sapiens_hsa053230.85884532
61Non-homologous end-joining_Homo sapiens_hsa034500.85700997
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85298996
63GnRH signaling pathway_Homo sapiens_hsa049120.83687858
64Nucleotide excision repair_Homo sapiens_hsa034200.83364319
65Morphine addiction_Homo sapiens_hsa050320.81890435
66Phagosome_Homo sapiens_hsa041450.80968731
67Glutamatergic synapse_Homo sapiens_hsa047240.80658807
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80379671
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79560342
70Arginine and proline metabolism_Homo sapiens_hsa003300.79449612
71Cholinergic synapse_Homo sapiens_hsa047250.79262837
72Pancreatic secretion_Homo sapiens_hsa049720.78945822
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74697578
74Oxytocin signaling pathway_Homo sapiens_hsa049210.74681338
75RNA transport_Homo sapiens_hsa030130.72914785
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72505734
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72360830
78Thyroid cancer_Homo sapiens_hsa052160.72024576
79Sulfur metabolism_Homo sapiens_hsa009200.71817622
80Olfactory transduction_Homo sapiens_hsa047400.71729542
81Spliceosome_Homo sapiens_hsa030400.70711450
82Melanogenesis_Homo sapiens_hsa049160.69534346
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68745399
84Cocaine addiction_Homo sapiens_hsa050300.67592054
85mRNA surveillance pathway_Homo sapiens_hsa030150.67523264
86Fructose and mannose metabolism_Homo sapiens_hsa000510.66667570
87Renin secretion_Homo sapiens_hsa049240.66020113
88Purine metabolism_Homo sapiens_hsa002300.65862847
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65038358
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64960674
91p53 signaling pathway_Homo sapiens_hsa041150.64789288
92Gastric acid secretion_Homo sapiens_hsa049710.64591054
93Type I diabetes mellitus_Homo sapiens_hsa049400.64193324
94Lysosome_Homo sapiens_hsa041420.63034643
95Metabolic pathways_Homo sapiens_hsa011000.60889982
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60152171
97Mismatch repair_Homo sapiens_hsa034300.59732646
98Salivary secretion_Homo sapiens_hsa049700.59224245
99Calcium signaling pathway_Homo sapiens_hsa040200.55416117
100RNA degradation_Homo sapiens_hsa030180.54974134
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53995164
102Epstein-Barr virus infection_Homo sapiens_hsa051690.53732191
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.51718547
104Propanoate metabolism_Homo sapiens_hsa006400.51035342
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51004006
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.50966635
107Cell cycle_Homo sapiens_hsa041100.50881693
108Legionellosis_Homo sapiens_hsa051340.50182498
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50051729
110Fatty acid metabolism_Homo sapiens_hsa012120.49547530
111Hippo signaling pathway_Homo sapiens_hsa043900.49165625
112VEGF signaling pathway_Homo sapiens_hsa043700.48243682
113Alcoholism_Homo sapiens_hsa050340.47936878
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.46766683
115Estrogen signaling pathway_Homo sapiens_hsa049150.45845142
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44820212
117Folate biosynthesis_Homo sapiens_hsa007900.43292864
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.42183369
119Salmonella infection_Homo sapiens_hsa051320.42006178
120N-Glycan biosynthesis_Homo sapiens_hsa005100.41881612
121Other glycan degradation_Homo sapiens_hsa005110.41687530
122Basal transcription factors_Homo sapiens_hsa030220.40819307
123Bladder cancer_Homo sapiens_hsa052190.40761510
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.40620543
125Phenylalanine metabolism_Homo sapiens_hsa003600.40091995
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38993903
127Melanoma_Homo sapiens_hsa052180.38073510
128Selenocompound metabolism_Homo sapiens_hsa004500.37724567
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37257320
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36558738
131Glioma_Homo sapiens_hsa052140.36442525
132Prion diseases_Homo sapiens_hsa050200.36225970
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35423448
134Pertussis_Homo sapiens_hsa051330.32935053
135cAMP signaling pathway_Homo sapiens_hsa040240.28941996
136Tuberculosis_Homo sapiens_hsa051520.28702342
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28249159
138Base excision repair_Homo sapiens_hsa034100.28190415
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27439535
140Homologous recombination_Homo sapiens_hsa034400.26805149
141Colorectal cancer_Homo sapiens_hsa052100.26706972
142Sphingolipid metabolism_Homo sapiens_hsa006000.26595486
143Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23145181
144Adherens junction_Homo sapiens_hsa045200.20107747
145Tyrosine metabolism_Homo sapiens_hsa003500.19249689
146Arginine biosynthesis_Homo sapiens_hsa002200.17688792
147Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.15894567
148Peroxisome_Homo sapiens_hsa041460.14365204

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