ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.72623211
2	proteasome assembly (GO:0043248)	4.03335691
3	CENP-A containing nucleosome assembly (GO:0034080)	4.02919802
4	chromatin remodeling at centromere (GO:0031055)	3.85249084
5	protein neddylation (GO:0045116)	3.84363105
6	DNA double-strand break processing (GO:0000729)	3.77764630
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.66933682
8	neural tube formation (GO:0001841)	3.61805022
9	branched-chain amino acid catabolic process (GO:0009083)	3.59837960
10	organelle disassembly (GO:1903008)	3.53872586
11	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.50321142
12	purine nucleobase biosynthetic process (GO:0009113)	3.44065395
13	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.41881210
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.41881210
15	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.41330738
16	gonadal mesoderm development (GO:0007506)	3.40320670
17	positive regulation of mitochondrial fission (GO:0090141)	3.39153812
18	cullin deneddylation (GO:0010388)	3.38795759
19	positive regulation of male gonad development (GO:2000020)	3.36984639
20	metallo-sulfur cluster assembly (GO:0031163)	3.35887199
21	iron-sulfur cluster assembly (GO:0016226)	3.35887199
22	pyrimidine nucleobase catabolic process (GO:0006208)	3.30691879
23	DNA damage response, detection of DNA damage (GO:0042769)	3.29035612
24	response to pheromone (GO:0019236)	3.28124097
25	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.26251474
26	ATP synthesis coupled proton transport (GO:0015986)	3.26251474
27	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.22618007
28	histone exchange (GO:0043486)	3.20257986
29	sequestering of actin monomers (GO:0042989)	3.17973744
30	preassembly of GPI anchor in ER membrane (GO:0016254)	3.17224128
31	histone mRNA metabolic process (GO:0008334)	3.15111249
32	protein deneddylation (GO:0000338)	3.13453299
33	regulation of cellular amino acid metabolic process (GO:0006521)	3.12635334
34	oxidative phosphorylation (GO:0006119)	3.10707034
35	glyoxylate metabolic process (GO:0046487)	3.10668437
36	mannosylation (GO:0097502)	3.10633050
37	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.09941010
38	inner mitochondrial membrane organization (GO:0007007)	3.09370300
39	spliceosomal snRNP assembly (GO:0000387)	3.09099177
40	GPI anchor biosynthetic process (GO:0006506)	3.06815634
41	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.06524571
42	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.04498612
43	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.03959501
44	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.02910341
45	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.02635671
46	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.00940919
47	negative regulation of ligase activity (GO:0051352)	2.99495487
48	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.99495487
49	cholesterol biosynthetic process (GO:0006695)	2.99321481
50	GPI anchor metabolic process (GO:0006505)	2.98716844
51	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.98683112
52	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.97678666
53	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.96749680
54	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.96749680
55	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.96749680
56	negative regulation of DNA recombination (GO:0045910)	2.92251382
57	regulation of female gonad development (GO:2000194)	2.92147696
58	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.91975805
59	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.91975805
60	ribonucleoprotein complex disassembly (GO:0032988)	2.89045560
61	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.88599013
62	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.86335203
63	serine family amino acid catabolic process (GO:0009071)	2.85048526
64	DNA replication-independent nucleosome organization (GO:0034724)	2.84176461
65	DNA replication-independent nucleosome assembly (GO:0006336)	2.84176461
66	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.84098309
67	glycerol ether metabolic process (GO:0006662)	2.83920894
68	ether lipid metabolic process (GO:0046485)	2.83585328
69	rRNA modification (GO:0000154)	2.82403068
70	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.80858338
71	branched-chain amino acid metabolic process (GO:0009081)	2.80154054
72	protein K11-linked ubiquitination (GO:0070979)	2.80106810
73	ubiquinone metabolic process (GO:0006743)	2.79584524
74	aggressive behavior (GO:0002118)	2.78900315
75	indole-containing compound catabolic process (GO:0042436)	2.78778347
76	indolalkylamine catabolic process (GO:0046218)	2.78778347
77	tryptophan catabolic process (GO:0006569)	2.78778347
78	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.78616263
79	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.78236148
80	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.78236148
81	DNA ligation (GO:0006266)	2.78213858
82	regulation of male gonad development (GO:2000018)	2.78029845
83	L-serine metabolic process (GO:0006563)	2.75457244
84	sterol biosynthetic process (GO:0016126)	2.73175909
85	nucleobase biosynthetic process (GO:0046112)	2.72752110
86	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.72003706
87	platelet dense granule organization (GO:0060155)	2.71675877
88	cytidine metabolic process (GO:0046087)	2.69050033
89	cytidine catabolic process (GO:0006216)	2.69050033
90	cytidine deamination (GO:0009972)	2.69050033
91	glycine metabolic process (GO:0006544)	2.68919879
92	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.67177265
93	regulation of mitotic spindle checkpoint (GO:1903504)	2.67177265
94	GMP metabolic process (GO:0046037)	2.65282501
95	ether metabolic process (GO:0018904)	2.65137489
96	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.65123887
97	seminiferous tubule development (GO:0072520)	2.64160328
98	tryptophan metabolic process (GO:0006568)	2.63589614
99	amino acid salvage (GO:0043102)	2.61941574
100	L-methionine biosynthetic process (GO:0071265)	2.61941574

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.35382583
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.19480682
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.34847000
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.18200822
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.08739069
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.88051786
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.85804254
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.85367640
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.73167735
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.70709421
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.58125879
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.56607464
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.56072402
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.54099783
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.44644301
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.41705956
17	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.40786013
18	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.34209155
19	EWS_26573619_Chip-Seq_HEK293_Human	2.33093457
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.29396444
21	FUS_26573619_Chip-Seq_HEK293_Human	2.20952106
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.20465096
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.18096019
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.13977997
25	VDR_22108803_ChIP-Seq_LS180_Human	2.13415174
26	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.07200786
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.94019201
28	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.87607931
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81686109
30	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.81472307
31	P300_19829295_ChIP-Seq_ESCs_Human	1.77768059
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.77454672
33	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.76113764
34	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.71431904
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.64773498
36	FOXP3_21729870_ChIP-Seq_TREG_Human	1.63495866
37	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.61746861
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.61100809
39	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.57923951
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.53314535
41	GBX2_23144817_ChIP-Seq_PC3_Human	1.52455436
42	DCP1A_22483619_ChIP-Seq_HELA_Human	1.48580198
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48219177
44	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.40580504
45	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.39561304
46	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.39343729
47	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.37418192
48	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.36885177
49	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.36548806
50	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.31003365
51	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.29409103
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.28831641
53	TTF2_22483619_ChIP-Seq_HELA_Human	1.28385926
54	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.27220722
55	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.27001370
56	GABP_19822575_ChIP-Seq_HepG2_Human	1.22275032
57	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.21754712
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21631521
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20629300
60	HTT_18923047_ChIP-ChIP_STHdh_Human	1.19592460
61	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.19295909
62	ER_23166858_ChIP-Seq_MCF-7_Human	1.15906637
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.15410152
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14895640
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13897456
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.13393081
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.13393081
68	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.11428953
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10253529
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10253529
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.08227298
72	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04848991
73	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04191356
74	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.03774714
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02577615
76	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01743387
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01435028
78	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99883131
79	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.99835308
80	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.98975213
81	IRF1_19129219_ChIP-ChIP_H3396_Human	0.95781881
82	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.95381710
83	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.95110946
84	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.94357282
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.93675057
86	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.92987485
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.92658629
88	AR_25329375_ChIP-Seq_VCAP_Human	0.91709173
89	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.90947108
90	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.90471375
91	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.89958459
92	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.89150954
93	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.87823014
94	E2F7_22180533_ChIP-Seq_HELA_Human	0.87362149
95	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.86474632
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.86417586
97	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.85732563
98	AR_20517297_ChIP-Seq_VCAP_Human	0.84984132
99	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.84319208
100	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.83302537

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006072_abnormal_retinal_apoptosis	4.09696043
2	MP0003806_abnormal_nucleotide_metabolis	3.18713464
3	MP0002736_abnormal_nociception_after	2.98396328
4	MP0009697_abnormal_copulation	2.93936748
5	MP0008875_abnormal_xenobiotic_pharmacok	2.75383355
6	MP0006292_abnormal_olfactory_placode	2.69143398
7	MP0000372_irregular_coat_pigmentation	2.54347529
8	MP0005253_abnormal_eye_physiology	2.46327617
9	MP0004147_increased_porphyrin_level	2.45216447
10	MP0001188_hyperpigmentation	2.28580344
11	MP0005084_abnormal_gallbladder_morpholo	2.05401207
12	MP0005085_abnormal_gallbladder_physiolo	2.01185393
13	MP0008058_abnormal_DNA_repair	1.98580087
14	MP0001968_abnormal_touch/_nociception	1.95659557
15	MP0001529_abnormal_vocalization	1.93378973
16	MP0003122_maternal_imprinting	1.87438815
17	MP0004142_abnormal_muscle_tone	1.84895885
18	MP0006035_abnormal_mitochondrial_morpho	1.74997436
19	MP0002090_abnormal_vision	1.73543514
20	MP0003890_abnormal_embryonic-extraembry	1.72879962
21	MP0002735_abnormal_chemical_nociception	1.67459724
22	MP0003693_abnormal_embryo_hatching	1.66370082
23	MP0000569_abnormal_digit_pigmentation	1.63676297
24	MP0001984_abnormal_olfaction	1.63234644
25	MP0003195_calcinosis	1.62667268
26	MP0005551_abnormal_eye_electrophysiolog	1.61861692
27	MP0005187_abnormal_penis_morphology	1.60015368
28	MP0003252_abnormal_bile_duct	1.58819646
29	MP0010094_abnormal_chromosome_stability	1.56947894
30	MP0001293_anophthalmia	1.53965054
31	MP0004133_heterotaxia	1.50681309
32	MP0005646_abnormal_pituitary_gland	1.48663809
33	MP0005645_abnormal_hypothalamus_physiol	1.48104366
34	MP0005499_abnormal_olfactory_system	1.47631390
35	MP0005394_taste/olfaction_phenotype	1.47631390
36	MP0003718_maternal_effect	1.44958060
37	MP0002138_abnormal_hepatobiliary_system	1.41878291
38	MP0002653_abnormal_ependyma_morphology	1.41590900
39	MP0006276_abnormal_autonomic_nervous	1.37495969
40	MP0008873_increased_physiological_sensi	1.34620389
41	MP0003880_abnormal_central_pattern	1.34304759
42	MP0003567_abnormal_fetal_cardiomyocyte	1.34248583
43	MP0003011_delayed_dark_adaptation	1.32975710
44	MP0005391_vision/eye_phenotype	1.32152798
45	MP0005367_renal/urinary_system_phenotyp	1.31206600
46	MP0000516_abnormal_urinary_system	1.31206600
47	MP0003283_abnormal_digestive_organ	1.26388215
48	MP0003221_abnormal_cardiomyocyte_apopto	1.25751743
49	MP0008872_abnormal_physiological_respon	1.22867027
50	MP0009046_muscle_twitch	1.22615337
51	MP0003315_abnormal_perineum_morphology	1.22460368
52	MP0008932_abnormal_embryonic_tissue	1.22314088
53	MP0008789_abnormal_olfactory_epithelium	1.22168344
54	MP0004957_abnormal_blastocyst_morpholog	1.20623765
55	MP0000631_abnormal_neuroendocrine_gland	1.18788750
56	MP0003186_abnormal_redox_activity	1.15771786
57	MP0006036_abnormal_mitochondrial_physio	1.14539979
58	MP0000778_abnormal_nervous_system	1.14473770
59	MP0002102_abnormal_ear_morphology	1.08614744
60	MP0002557_abnormal_social/conspecific_i	1.07424870
61	MP0000358_abnormal_cell_content/	1.05589596
62	MP0002067_abnormal_sensory_capabilities	1.05381048
63	MP0002282_abnormal_trachea_morphology	1.03344153
64	MP0001764_abnormal_homeostasis	1.03011390
65	MP0002938_white_spotting	1.02641404
66	MP0002139_abnormal_hepatobiliary_system	1.01648350
67	MP0003121_genomic_imprinting	1.01434493
68	MP0003136_yellow_coat_color	1.01305039
69	MP0005423_abnormal_somatic_nervous	0.99607677
70	MP0002751_abnormal_autonomic_nervous	0.94390307
71	MP0002272_abnormal_nervous_system	0.94006889
72	MP0001485_abnormal_pinna_reflex	0.93350881
73	MP0006054_spinal_hemorrhage	0.90429552
74	MP0002572_abnormal_emotion/affect_behav	0.90337234
75	MP0002928_abnormal_bile_duct	0.89633208
76	MP0005195_abnormal_posterior_eye	0.88883475
77	MP0004215_abnormal_myocardial_fiber	0.86476401
78	MP0005377_hearing/vestibular/ear_phenot	0.86474647
79	MP0003878_abnormal_ear_physiology	0.86474647
80	MP0003937_abnormal_limbs/digits/tail_de	0.86196219
81	MP0001727_abnormal_embryo_implantation	0.84661008
82	MP0002233_abnormal_nose_morphology	0.84243525
83	MP0005360_urolithiasis	0.82898610
84	MP0001929_abnormal_gametogenesis	0.82220920
85	MP0001286_abnormal_eye_development	0.81917844
86	MP0003119_abnormal_digestive_system	0.79917562
87	MP0003638_abnormal_response/metabolism_	0.79745452
88	MP0002638_abnormal_pupillary_reflex	0.78395940
89	MP0005636_abnormal_mineral_homeostasis	0.77815114
90	MP0005410_abnormal_fertilization	0.77510814
91	MP0004782_abnormal_surfactant_physiolog	0.76662207
92	MP0008007_abnormal_cellular_replicative	0.75586949
93	MP0003786_premature_aging	0.75482948
94	MP0002095_abnormal_skin_pigmentation	0.73752014
95	MP0000647_abnormal_sebaceous_gland	0.73368059
96	MP0009745_abnormal_behavioral_response	0.73312252
97	MP0005365_abnormal_bile_salt	0.72962226
98	MP0003077_abnormal_cell_cycle	0.72531626
99	MP0009785_altered_susceptibility_to	0.72115995
100	MP0008995_early_reproductive_senescence	0.69615275

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.01270144
2	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.87949449
3	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.87949449
4	Acute necrotizing encephalopathy (HP:0006965)	3.54006346
5	Mitochondrial inheritance (HP:0001427)	3.33250478
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.30573823
7	Increased hepatocellular lipid droplets (HP:0006565)	3.25501262
8	Acute encephalopathy (HP:0006846)	3.24613188
9	Lipid accumulation in hepatocytes (HP:0006561)	3.19353016
10	Hyperglycinemia (HP:0002154)	3.19152771
11	Abdominal situs inversus (HP:0003363)	3.16773265
12	Abnormality of abdominal situs (HP:0011620)	3.16773265
13	Increased CSF lactate (HP:0002490)	3.03668341
14	Renal Fanconi syndrome (HP:0001994)	2.98442647
15	Hyperglycinuria (HP:0003108)	2.90137096
16	Progressive macrocephaly (HP:0004481)	2.87086741
17	Hepatocellular necrosis (HP:0001404)	2.86395615
18	Abnormality of serine family amino acid metabolism (HP:0010894)	2.80836315
19	Abnormality of glycine metabolism (HP:0010895)	2.80836315
20	Cerebral edema (HP:0002181)	2.79882848
21	Increased serum pyruvate (HP:0003542)	2.79382002
22	Pancreatic cysts (HP:0001737)	2.75050061
23	Abnormality of serum amino acid levels (HP:0003112)	2.68958647
24	Medial flaring of the eyebrow (HP:0010747)	2.67163516
25	Methylmalonic acidemia (HP:0002912)	2.65908683
26	Gait imbalance (HP:0002141)	2.62262189
27	Pancreatic fibrosis (HP:0100732)	2.58901356
28	Increased intramyocellular lipid droplets (HP:0012240)	2.56342468
29	Generalized aminoaciduria (HP:0002909)	2.55944111
30	Hypothermia (HP:0002045)	2.54433142
31	Hepatic necrosis (HP:0002605)	2.53795815
32	Type I transferrin isoform profile (HP:0003642)	2.53255917
33	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.51703242
34	Abnormality of alanine metabolism (HP:0010916)	2.51703242
35	Hyperalaninemia (HP:0003348)	2.51703242
36	Exertional dyspnea (HP:0002875)	2.50215157
37	Congenital primary aphakia (HP:0007707)	2.48624961
38	Abolished electroretinogram (ERG) (HP:0000550)	2.47819920
39	Sclerocornea (HP:0000647)	2.44387038
40	3-Methylglutaconic aciduria (HP:0003535)	2.44097363
41	Lactic acidosis (HP:0003128)	2.42204525
42	Median cleft lip (HP:0000161)	2.38238093
43	Nephronophthisis (HP:0000090)	2.37387980
44	High anterior hairline (HP:0009890)	2.36741828
45	Abnormality of glycolysis (HP:0004366)	2.36606281
46	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.36446892
47	Nephrogenic diabetes insipidus (HP:0009806)	2.35757864
48	Aplastic anemia (HP:0001915)	2.35442315
49	Lethargy (HP:0001254)	2.30071026
50	Increased serum lactate (HP:0002151)	2.28230109
51	Abnormality of midbrain morphology (HP:0002418)	2.19647074
52	Molar tooth sign on MRI (HP:0002419)	2.19647074
53	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.19550308
54	True hermaphroditism (HP:0010459)	2.19147975
55	Postaxial foot polydactyly (HP:0001830)	2.18636622
56	Reduced antithrombin III activity (HP:0001976)	2.18536914
57	Neuroendocrine neoplasm (HP:0100634)	2.17129394
58	Septo-optic dysplasia (HP:0100842)	2.16188609
59	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.14556080
60	Abnormality of the anterior horn cell (HP:0006802)	2.12128425
61	Degeneration of anterior horn cells (HP:0002398)	2.12128425
62	Increased muscle lipid content (HP:0009058)	2.11768220
63	Abnormality of methionine metabolism (HP:0010901)	2.05649093
64	Genital tract atresia (HP:0001827)	2.03944223
65	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.01908854
66	Abnormal protein N-linked glycosylation (HP:0012347)	2.01908854
67	Abnormal protein glycosylation (HP:0012346)	2.01908854
68	Abnormal glycosylation (HP:0012345)	2.01908854
69	Abnormality of the renal medulla (HP:0100957)	2.00925628
70	Lissencephaly (HP:0001339)	2.00408653
71	Pheochromocytoma (HP:0002666)	1.99140294
72	Congenital, generalized hypertrichosis (HP:0004540)	1.97431713
73	Vaginal atresia (HP:0000148)	1.96285484
74	Delayed CNS myelination (HP:0002188)	1.95771530
75	Colon cancer (HP:0003003)	1.93854469
76	Volvulus (HP:0002580)	1.93364297
77	Preaxial hand polydactyly (HP:0001177)	1.92331862
78	Methylmalonic aciduria (HP:0012120)	1.90143962
79	Short tibia (HP:0005736)	1.89880286
80	Amyotrophic lateral sclerosis (HP:0007354)	1.87971954
81	Hypoplastic pelvis (HP:0008839)	1.87553482
82	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.87333324
83	Leukodystrophy (HP:0002415)	1.86282247
84	Shoulder girdle muscle weakness (HP:0003547)	1.85677123
85	Abnormal gallbladder physiology (HP:0012438)	1.82117731
86	Cholecystitis (HP:0001082)	1.82117731
87	CNS demyelination (HP:0007305)	1.81706494
88	Abnormality of the hip-girdle musculature (HP:0001445)	1.81374351
89	Abnormality of the musculature of the pelvis (HP:0001469)	1.81374351
90	Broad foot (HP:0001769)	1.79611399
91	Split foot (HP:0001839)	1.76480694
92	Medulloblastoma (HP:0002885)	1.75002332
93	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.74954943
94	Postaxial hand polydactyly (HP:0001162)	1.74865316
95	Disproportionate short-trunk short stature (HP:0003521)	1.74509430
96	Glycosuria (HP:0003076)	1.74280710
97	Abnormality of urine glucose concentration (HP:0011016)	1.74280710
98	Abnormality of macular pigmentation (HP:0008002)	1.71805277
99	Limb-girdle muscle atrophy (HP:0003797)	1.71715564
100	Meckel diverticulum (HP:0002245)	1.71428770

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.87872088
2	BCKDK	3.20332411
3	SRPK1	2.60157144
4	ZAK	2.53011079
5	BUB1	2.43841103
6	GRK1	2.41781985
7	BCR	2.40808362
8	TRIM28	2.38014964
9	TNIK	2.19979055
10	VRK1	2.15992580
11	EIF2AK3	2.08863075
12	NEK1	2.07232530
13	NUAK1	2.02430998
14	WNK3	2.00310460
15	MKNK1	1.97501320
16	BMPR1B	1.94102159
17	VRK2	1.93576308
18	MKNK2	1.83133502
19	ERBB3	1.76654944
20	BRSK2	1.72470588
21	MAP2K7	1.68578643
22	TAOK3	1.67399760
23	PBK	1.66302356
24	PLK3	1.59327377
25	ACVR1B	1.57052326
26	MAPK13	1.54048451
27	PLK4	1.46780147
28	PINK1	1.42179446
29	MAP3K4	1.37986949
30	CDC7	1.32658973
31	TGFBR1	1.26306904
32	CSNK1G2	1.22931075
33	FLT3	1.22046175
34	TTK	1.19189703
35	CASK	1.12429477
36	CSNK1G1	1.11430537
37	TSSK6	1.10480078
38	MAP3K12	1.08352599
39	TLK1	1.07661114
40	CSNK1G3	1.07402901
41	MARK1	1.05142001
42	DYRK2	1.00344857
43	RPS6KA4	1.00147424
44	CSNK1A1L	0.93770911
45	KDR	0.93057766
46	CHEK2	0.89598898
47	EIF2AK1	0.86939008
48	LIMK1	0.84757662
49	PLK1	0.84473097
50	ADRBK2	0.84360858
51	TESK1	0.84250202
52	MATK	0.83897879
53	WNK4	0.81231393
54	MINK1	0.81051165
55	TXK	0.79531576
56	WEE1	0.78816674
57	TESK2	0.75984272
58	NEK2	0.74212344
59	PNCK	0.72117302
60	CDK3	0.71945594
61	TEC	0.70741337
62	ERBB4	0.69663151
63	BRSK1	0.68813695
64	ATR	0.68687711
65	PLK2	0.68612142
66	DYRK3	0.68186666
67	EIF2AK2	0.65912388
68	AURKA	0.63859313
69	TAF1	0.61160493
70	NME1	0.60504184
71	SIK2	0.56052143
72	AURKB	0.54710878
73	MUSK	0.53243919
74	CAMK2A	0.52753378
75	PKN1	0.52476307
76	PRKCG	0.50277311
77	CDK18	0.49472054
78	RPS6KA5	0.49118318
79	ATM	0.48893712
80	PIK3CG	0.48882756
81	CDK14	0.48292329
82	PIM2	0.47802417
83	DYRK1B	0.47308201
84	INSRR	0.46126944
85	MST4	0.45402079
86	PRKCE	0.42394885
87	CDK15	0.42341029
88	KIT	0.41846633
89	MAP3K11	0.41229811
90	MAPKAPK5	0.38224818
91	CDK11A	0.37890773
92	MAP3K5	0.36980239
93	CSNK2A1	0.36622580
94	STK38L	0.36500377
95	DAPK1	0.35925845
96	IGF1R	0.35819386
97	CSNK1A1	0.34843031
98	OXSR1	0.33955023
99	SIK3	0.33903922
100	MAP2K4	0.33870388

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.62428006
2	Protein export_Homo sapiens_hsa03060	3.14229226
3	Caffeine metabolism_Homo sapiens_hsa00232	3.01933763
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.62225893
5	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.28918754
6	Parkinsons disease_Homo sapiens_hsa05012	2.27261600
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18363775
8	Propanoate metabolism_Homo sapiens_hsa00640	2.17678607
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.09985689
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.09092046
11	Steroid biosynthesis_Homo sapiens_hsa00100	2.05497071
12	Mismatch repair_Homo sapiens_hsa03430	1.98741377
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.86124748
14	Butanoate metabolism_Homo sapiens_hsa00650	1.82398403
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.80601275
16	Homologous recombination_Homo sapiens_hsa03440	1.78448436
17	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.71355937
18	Phototransduction_Homo sapiens_hsa04744	1.71157475
19	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.70169193
20	DNA replication_Homo sapiens_hsa03030	1.69432547
21	RNA polymerase_Homo sapiens_hsa03020	1.66953276
22	Peroxisome_Homo sapiens_hsa04146	1.66563966
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.66559760
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.62097277
25	Huntingtons disease_Homo sapiens_hsa05016	1.37137743
26	Base excision repair_Homo sapiens_hsa03410	1.36650890
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.34602885
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.33006134
29	Alzheimers disease_Homo sapiens_hsa05010	1.32125152
30	RNA degradation_Homo sapiens_hsa03018	1.30899676
31	Asthma_Homo sapiens_hsa05310	1.30883318
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.30758957
33	Spliceosome_Homo sapiens_hsa03040	1.30155611
34	RNA transport_Homo sapiens_hsa03013	1.28413958
35	Ribosome_Homo sapiens_hsa03010	1.27426972
36	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.27092060
37	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.27090461
38	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.26301766
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.22156702
40	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.21507714
41	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.21247347
42	Pyruvate metabolism_Homo sapiens_hsa00620	1.16432020
43	Pyrimidine metabolism_Homo sapiens_hsa00240	1.15480181
44	Carbon metabolism_Homo sapiens_hsa01200	1.14692814
45	One carbon pool by folate_Homo sapiens_hsa00670	1.13769071
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.12652490
47	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.12527832
48	Fatty acid elongation_Homo sapiens_hsa00062	1.10312922
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.06220929
50	Nucleotide excision repair_Homo sapiens_hsa03420	1.05691027
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.02349400
52	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01635815
53	Graft-versus-host disease_Homo sapiens_hsa05332	0.98426138
54	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.97399784
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.96064260
56	Purine metabolism_Homo sapiens_hsa00230	0.95816797
57	Basal transcription factors_Homo sapiens_hsa03022	0.94796613
58	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.93204742
59	Retinol metabolism_Homo sapiens_hsa00830	0.92434967
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.89800256
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88791714
62	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.87900464
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.85586774
64	Fatty acid degradation_Homo sapiens_hsa00071	0.85277770
65	Metabolic pathways_Homo sapiens_hsa01100	0.82043455
66	Nitrogen metabolism_Homo sapiens_hsa00910	0.76971778
67	Antigen processing and presentation_Homo sapiens_hsa04612	0.76367295
68	Nicotine addiction_Homo sapiens_hsa05033	0.75885758
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75338172
70	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.74708369
71	Allograft rejection_Homo sapiens_hsa05330	0.74585191
72	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.71988904
73	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.71505051
74	Glutathione metabolism_Homo sapiens_hsa00480	0.69303638
75	Olfactory transduction_Homo sapiens_hsa04740	0.68258538
76	Type I diabetes mellitus_Homo sapiens_hsa04940	0.67510529
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.63522460
78	Folate biosynthesis_Homo sapiens_hsa00790	0.61632960
79	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.58319553
80	Rheumatoid arthritis_Homo sapiens_hsa05323	0.57792536
81	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.48857683
82	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.47972019
83	Cell cycle_Homo sapiens_hsa04110	0.47669894
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47139334
85	Primary immunodeficiency_Homo sapiens_hsa05340	0.45785743
86	Alcoholism_Homo sapiens_hsa05034	0.45284126
87	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.44745537
88	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.42997103
89	Cardiac muscle contraction_Homo sapiens_hsa04260	0.42530493
90	mRNA surveillance pathway_Homo sapiens_hsa03015	0.42313751
91	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.35380693
92	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.35033282
93	Selenocompound metabolism_Homo sapiens_hsa00450	0.34229050
94	Complement and coagulation cascades_Homo sapiens_hsa04610	0.32231798
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.32081674
96	Linoleic acid metabolism_Homo sapiens_hsa00591	0.30955730
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30741855
98	Oocyte meiosis_Homo sapiens_hsa04114	0.30160227
99	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.29723525
100	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.28118931

RHEBP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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