ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of integrated proviral latency (GO:0075713)	5.26758630
2	negative regulation of fibrinolysis (GO:0051918)	5.21713516
3	ribosome assembly (GO:0042255)	4.86166190
4	regulation of fibrinolysis (GO:0051917)	4.45017016
5	DNA topological change (GO:0006265)	4.32697648
6	DNA unwinding involved in DNA replication (GO:0006268)	4.24196960
7	establishment of viral latency (GO:0019043)	4.17967783
8	blood coagulation, intrinsic pathway (GO:0007597)	4.15727843
9	DNA ligation (GO:0006266)	3.92101679
10	CENP-A containing nucleosome assembly (GO:0034080)	3.87933156
11	regulation of transcription from RNA polymerase I promoter (GO:0006356)	3.86682401
12	formation of translation preinitiation complex (GO:0001731)	3.84275724
13	very-low-density lipoprotein particle assembly (GO:0034379)	3.75070047
14	chromatin remodeling at centromere (GO:0031055)	3.72702688
15	cholesterol biosynthetic process (GO:0006695)	3.72256644
16	L-phenylalanine metabolic process (GO:0006558)	3.46870356
17	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.46870356
18	proteasome assembly (GO:0043248)	3.45464612
19	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.42190315
20	L-phenylalanine catabolic process (GO:0006559)	3.42190315
21	fibrinolysis (GO:0042730)	3.39274063
22	membrane budding (GO:0006900)	3.33097832
23	mitotic metaphase plate congression (GO:0007080)	3.31844649
24	histone exchange (GO:0043486)	3.30106927
25	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.26873599
26	polyketide metabolic process (GO:0030638)	3.25820420
27	doxorubicin metabolic process (GO:0044598)	3.25820420
28	daunorubicin metabolic process (GO:0044597)	3.25820420
29	sterol biosynthetic process (GO:0016126)	3.25657483
30	alpha-linolenic acid metabolic process (GO:0036109)	3.24549330
31	protein localization to kinetochore (GO:0034501)	3.18793688
32	DNA strand elongation involved in DNA replication (GO:0006271)	3.18788363
33	plasma lipoprotein particle assembly (GO:0034377)	3.17949368
34	DNA replication-independent nucleosome organization (GO:0034724)	3.17140985
35	DNA replication-independent nucleosome assembly (GO:0006336)	3.17140985
36	DNA replication-dependent nucleosome assembly (GO:0006335)	3.14283862
37	DNA replication-dependent nucleosome organization (GO:0034723)	3.14283862
38	regulation of protein activation cascade (GO:2000257)	3.13263268
39	NADPH regeneration (GO:0006740)	3.13137274
40	regulation of cholesterol esterification (GO:0010872)	3.10732431
41	protein carboxylation (GO:0018214)	3.10396178
42	peptidyl-glutamic acid carboxylation (GO:0017187)	3.10396178
43	purine nucleobase biosynthetic process (GO:0009113)	3.10366492
44	organelle disassembly (GO:1903008)	3.10361711
45	DNA strand elongation (GO:0022616)	3.05640097
46	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.05327544
47	glyoxylate metabolic process (GO:0046487)	3.01074348
48	regulation of plasminogen activation (GO:0010755)	3.01003045
49	DNA damage response, detection of DNA damage (GO:0042769)	2.93493759
50	regulation of DNA damage checkpoint (GO:2000001)	2.91993694
51	hyperosmotic salinity response (GO:0042538)	2.91716226
52	intestinal cholesterol absorption (GO:0030299)	2.87720037
53	regulation of complement activation (GO:0030449)	2.87680544
54	apoptotic DNA fragmentation (GO:0006309)	2.86977070
55	double-strand break repair via nonhomologous end joining (GO:0006303)	2.86006391
56	non-recombinational repair (GO:0000726)	2.86006391
57	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.81068507
58	deoxyribonucleotide biosynthetic process (GO:0009263)	2.80676307
59	aminoglycoside antibiotic metabolic process (GO:0030647)	2.80302450
60	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.79929675
61	pentose-phosphate shunt (GO:0006098)	2.79812586
62	glycine metabolic process (GO:0006544)	2.79012983
63	regulation of helicase activity (GO:0051095)	2.78532233
64	ATP-dependent chromatin remodeling (GO:0043044)	2.78261439
65	pyrimidine dimer repair (GO:0006290)	2.77795417
66	negative regulation of mRNA metabolic process (GO:1903312)	2.76463572
67	positive regulation of hemostasis (GO:1900048)	2.73531910
68	positive regulation of blood coagulation (GO:0030194)	2.73531910
69	galactose catabolic process (GO:0019388)	2.72448375
70	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.70729107
71	mRNA splicing, via spliceosome (GO:0000398)	2.68612582
72	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)	2.68612582
73	negative regulation of mRNA processing (GO:0050686)	2.68314784
74	IMP metabolic process (GO:0046040)	2.65840009
75	protein localization to chromosome, centromeric region (GO:0071459)	2.65693592
76	serine family amino acid catabolic process (GO:0009071)	2.64467703
77	ribonucleoprotein complex disassembly (GO:0032988)	2.63042133
78	serine family amino acid metabolic process (GO:0009069)	2.62447137
79	viral mRNA export from host cell nucleus (GO:0046784)	2.62194765
80	RNA splicing, via transesterification reactions (GO:0000375)	2.62166032
81	serine family amino acid biosynthetic process (GO:0009070)	2.62095776
82	alternative mRNA splicing, via spliceosome (GO:0000380)	2.61163229
83	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.61033646
84	metaphase plate congression (GO:0051310)	2.60536381
85	low-density lipoprotein particle remodeling (GO:0034374)	2.58511819
86	spliceosomal snRNP assembly (GO:0000387)	2.55742021
87	peptidyl-arginine N-methylation (GO:0035246)	2.55263337
88	peptidyl-arginine methylation (GO:0018216)	2.55263337
89	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.54251532
90	regulation of centriole replication (GO:0046599)	2.52657058
91	positive regulation of megakaryocyte differentiation (GO:0045654)	2.51697223
92	positive regulation of coagulation (GO:0050820)	2.51487478
93	nucleobase biosynthetic process (GO:0046112)	2.50234571
94	protein maturation by protein folding (GO:0022417)	2.49442050
95	negative regulation of sterol transport (GO:0032372)	2.48420268
96	negative regulation of cholesterol transport (GO:0032375)	2.48420268
97	regulation of cell-cell adhesion mediated by cadherin (GO:2000047)	2.47965181
98	protein-lipid complex assembly (GO:0065005)	2.47893680
99	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.47745623
100	telomere maintenance via semi-conservative replication (GO:0032201)	2.46574915

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.82281177
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.82590549
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.52214729
4	AR_21909140_ChIP-Seq_LNCAP_Human	3.43036598
5	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.36863872
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.35806098
7	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.96837900
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.90576343
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.70637346
10	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.69318471
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.61826734
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.61160110
13	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.58173428
14	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.53645085
15	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.52355099
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.38056242
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.36048623
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.33702116
19	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.31675057
20	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.30389246
21	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	2.27337709
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.19864595
23	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.15799642
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.15650711
25	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.06961526
26	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.06171840
27	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.05154465
28	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.00354564
29	ZFX_18555785_ChIP-Seq_MESCs_Mouse	2.00184002
30	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.99644933
31	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.99054290
32	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.97598253
33	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.97406503
34	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.85443773
35	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.82005067
36	TTF2_22483619_ChIP-Seq_HELA_Human	1.79701255
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.79212836
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.76519497
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.74037660
40	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.73978993
41	VDR_23849224_ChIP-Seq_CD4+_Human	1.73804291
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.73503584
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.73393622
44	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.72394113
45	CLOCK_20551151_ChIP-Seq_293T_Human	1.70609959
46	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.69960892
47	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.69418920
48	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.66602284
49	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.63704465
50	ZNF263_19887448_ChIP-Seq_K562_Human	1.62509424
51	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.55818918
52	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.51578564
53	FOXP3_21729870_ChIP-Seq_TREG_Human	1.49357346
54	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.49066772
55	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.48676860
56	XRN2_22483619_ChIP-Seq_HELA_Human	1.46570799
57	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.42299171
58	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.40795557
59	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.40255421
60	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.38852295
61	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.37469285
62	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.33437237
63	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.32517097
64	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	1.27411363
65	TAF15_26573619_Chip-Seq_HEK293_Human	1.26989655
66	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.25503002
67	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.25166827
68	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.22373961
69	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.22287090
70	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.21828187
71	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.17243166
72	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.16928294
73	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.15525867
74	EWS_26573619_Chip-Seq_HEK293_Human	1.15389350
75	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.15125547
76	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.14356730
77	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.13954271
78	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13526736
79	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.10911184
80	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.07323953
81	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.06831928
82	TFEB_21752829_ChIP-Seq_HELA_Human	1.06628498
83	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.05417890
84	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.04053551
85	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.03311809
86	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.02619415
87	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.01638192
88	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.00445423
89	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.00035184
90	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.99947952
91	IRF1_19129219_ChIP-ChIP_H3396_Human	0.99747024
92	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.99465579
93	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.98172196
94	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.95482247
95	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.92742121
96	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.89065174
97	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.86903943
98	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.85657040
99	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.84945254
100	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.84675576

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	3.77664958
2	MP0009697_abnormal_copulation	3.69436354
3	MP0003122_maternal_imprinting	2.95270214
4	MP0010368_abnormal_lymphatic_system	2.92459236
5	MP0003111_abnormal_nucleus_morphology	2.90809275
6	MP0002877_abnormal_melanocyte_morpholog	2.73269979
7	MP0004272_abnormal_basement_membrane	2.66454230
8	MP0005360_urolithiasis	2.61250192
9	MP0003567_abnormal_fetal_cardiomyocyte	2.56602026
10	MP0003693_abnormal_embryo_hatching	2.54122082
11	MP0000537_abnormal_urethra_morphology	2.51735583
12	MP0001666_abnormal_nutrient_absorption	2.45280614
13	MP0004957_abnormal_blastocyst_morpholog	2.41993188
14	MP0010094_abnormal_chromosome_stability	2.30909098
15	MP0006054_spinal_hemorrhage	2.30662998
16	MP0005085_abnormal_gallbladder_physiolo	2.30230174
17	MP0005365_abnormal_bile_salt	2.27327768
18	MP0008932_abnormal_embryonic_tissue	2.15592205
19	MP0001915_intracranial_hemorrhage	2.15015456
20	MP0003077_abnormal_cell_cycle	2.12788020
21	MP0003806_abnormal_nucleotide_metabolis	2.07364704
22	MP0008058_abnormal_DNA_repair	2.03462523
23	MP0005623_abnormal_meninges_morphology	2.02585876
24	MP0001293_anophthalmia	2.01103318
25	MP0008875_abnormal_xenobiotic_pharmacok	1.91858049
26	MP0006292_abnormal_olfactory_placode	1.85424952
27	MP0009278_abnormal_bone_marrow	1.84567288
28	MP0001730_embryonic_growth_arrest	1.80247766
29	MP0003186_abnormal_redox_activity	1.66963179
30	MP0003221_abnormal_cardiomyocyte_apopto	1.61092279
31	MP0002233_abnormal_nose_morphology	1.56565911
32	MP0005084_abnormal_gallbladder_morpholo	1.55754473
33	MP0003315_abnormal_perineum_morphology	1.50986031
34	MP0002697_abnormal_eye_size	1.48153215
35	MP0003868_abnormal_feces_composition	1.47600898
36	MP0003121_genomic_imprinting	1.45616326
37	MP0006072_abnormal_retinal_apoptosis	1.45343674
38	MP0008007_abnormal_cellular_replicative	1.44274064
39	MP0000465_gastrointestinal_hemorrhage	1.44048260
40	MP0002234_abnormal_pharynx_morphology	1.35358576
41	MP0005380_embryogenesis_phenotype	1.29533613
42	MP0001672_abnormal_embryogenesis/_devel	1.29533613
43	MP0002092_abnormal_eye_morphology	1.28473651
44	MP0001697_abnormal_embryo_size	1.25061988
45	MP0009053_abnormal_anal_canal	1.24486151
46	MP0003984_embryonic_growth_retardation	1.22161143
47	MP0000350_abnormal_cell_proliferation	1.20719323
48	MP0002080_prenatal_lethality	1.18191852
49	MP0003252_abnormal_bile_duct	1.17854318
50	MP0002088_abnormal_embryonic_growth/wei	1.17311232
51	MP0003656_abnormal_erythrocyte_physiolo	1.12307596
52	MP0003195_calcinosis	1.12195482
53	MP0005451_abnormal_body_composition	1.09990902
54	MP0005391_vision/eye_phenotype	1.05536743
55	MP0008260_abnormal_autophagy	1.04095202
56	MP0000358_abnormal_cell_content/	1.04028057
57	MP0003718_maternal_effect	1.03373625
58	MP0005058_abnormal_lysosome_morphology	1.02388443
59	MP0002085_abnormal_embryonic_tissue	1.01921834
60	MP0008789_abnormal_olfactory_epithelium	1.01742775
61	MP0005187_abnormal_penis_morphology	1.00431438
62	MP0002084_abnormal_developmental_patter	0.99848827
63	MP0001286_abnormal_eye_development	0.98577818
64	MP0002090_abnormal_vision	0.96574118
65	MP0002132_abnormal_respiratory_system	0.96262678
66	MP0000313_abnormal_cell_death	0.94923645
67	MP0004133_heterotaxia	0.94793176
68	MP0002086_abnormal_extraembryonic_tissu	0.94171220
69	MP0002909_abnormal_adrenal_gland	0.94056110
70	MP0005167_abnormal_blood-brain_barrier	0.93853025
71	MP0002282_abnormal_trachea_morphology	0.92636452
72	MP0003566_abnormal_cell_adhesion	0.91548033
73	MP0010329_abnormal_lipoprotein_level	0.90904804
74	MP0003941_abnormal_skin_development	0.89494274
75	MP0002138_abnormal_hepatobiliary_system	0.89422874
76	MP0005408_hypopigmentation	0.88870684
77	MP0000598_abnormal_liver_morphology	0.88857392
78	MP0000858_altered_metastatic_potential	0.88489088
79	MP0005397_hematopoietic_system_phenotyp	0.88073132
80	MP0001545_abnormal_hematopoietic_system	0.88073132
81	MP0003119_abnormal_digestive_system	0.88068704
82	MP0009840_abnormal_foam_cell	0.86389153
83	MP0009763_increased_sensitivity_to	0.86079169
84	MP0003937_abnormal_limbs/digits/tail_de	0.84996248
85	MP0005394_taste/olfaction_phenotype	0.81343574
86	MP0005499_abnormal_olfactory_system	0.81343574
87	MP0005253_abnormal_eye_physiology	0.78117907
88	MP0006035_abnormal_mitochondrial_morpho	0.78106182
89	MP0005384_cellular_phenotype	0.77682238
90	MP0000647_abnormal_sebaceous_gland	0.77356149
91	MP0005319_abnormal_enzyme/_coenzyme	0.75050165
92	MP0003136_yellow_coat_color	0.74680012
93	MP0001299_abnormal_eye_distance/	0.73325106
94	MP0002736_abnormal_nociception_after	0.72311575
95	MP0009672_abnormal_birth_weight	0.72283872
96	MP0004197_abnormal_fetal_growth/weight/	0.71814805
97	MP0001188_hyperpigmentation	0.71233317
98	MP0005464_abnormal_platelet_physiology	0.70840883
99	MP0003191_abnormal_cellular_cholesterol	0.70574760
100	MP0000609_abnormal_liver_physiology	0.68920164

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	6.08419991
2	Prolonged partial thromboplastin time (HP:0003645)	4.43998222
3	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.63344656
4	Hypobetalipoproteinemia (HP:0003563)	3.56633665
5	Multiple enchondromatosis (HP:0005701)	3.44425005
6	Intrahepatic cholestasis (HP:0001406)	3.20681214
7	Short tibia (HP:0005736)	3.06611988
8	Abnormality of the common coagulation pathway (HP:0010990)	3.01319745
9	Spastic diplegia (HP:0001264)	2.94991763
10	Joint hemorrhage (HP:0005261)	2.93971202
11	Abnormality of complement system (HP:0005339)	2.90635812
12	Sensorimotor neuropathy (HP:0007141)	2.90096866
13	Neonatal short-limb short stature (HP:0008921)	2.88022735
14	Dysautonomia (HP:0002459)	2.80380849
15	Orthostatic hypotension (HP:0001278)	2.78379170
16	Reduced antithrombin III activity (HP:0001976)	2.73917003
17	Hyperglycinemia (HP:0002154)	2.69224947
18	Abnormality of methionine metabolism (HP:0010901)	2.63101406
19	Bifid uvula (HP:0000193)	2.62408491
20	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.59871150
21	Menorrhagia (HP:0000132)	2.59340948
22	Cortical dysplasia (HP:0002539)	2.52483123
23	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.51876048
24	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.51876048
25	Increased serum pyruvate (HP:0003542)	2.49387484
26	Hyperglycinuria (HP:0003108)	2.49021197
27	Hypolipoproteinemia (HP:0010981)	2.43396815
28	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.39734024
29	Thrombophlebitis (HP:0004418)	2.39253229
30	Spontaneous abortion (HP:0005268)	2.38987140
31	Poor head control (HP:0002421)	2.29868355
32	Complement deficiency (HP:0004431)	2.29170722
33	Deviation of the thumb (HP:0009603)	2.27311574
34	Generalized aminoaciduria (HP:0002909)	2.26596374
35	Hepatocellular carcinoma (HP:0001402)	2.23968041
36	Abnormal autonomic nervous system physiology (HP:0012332)	2.21989419
37	Back pain (HP:0003418)	2.21489278
38	Vacuolated lymphocytes (HP:0001922)	2.20493565
39	Vertebral compression fractures (HP:0002953)	2.20116926
40	Proximal placement of thumb (HP:0009623)	2.19090438
41	Increased intramyocellular lipid droplets (HP:0012240)	2.15359662
42	Abnormality of serum amino acid levels (HP:0003112)	2.13481257
43	Pancreatic islet-cell hyperplasia (HP:0004510)	2.12692761
44	Fibular aplasia (HP:0002990)	2.09649195
45	Limb-girdle muscle atrophy (HP:0003797)	2.07507219
46	Papillary thyroid carcinoma (HP:0002895)	2.06910463
47	Abnormality of glycine metabolism (HP:0010895)	2.06349947
48	Abnormality of serine family amino acid metabolism (HP:0010894)	2.06349947
49	Abnormality of glycolysis (HP:0004366)	2.03104833
50	Deformed tarsal bones (HP:0008119)	2.02279167
51	Abnormality of the intrinsic pathway (HP:0010989)	2.01929117
52	Abolished electroretinogram (ERG) (HP:0000550)	2.01515351
53	Hypercholesterolemia (HP:0003124)	2.01415714
54	Bifid tongue (HP:0010297)	1.97910878
55	Tetraparesis (HP:0002273)	1.97634477
56	Spastic paraparesis (HP:0002313)	1.96033045
57	Morphological abnormality of the middle ear (HP:0008609)	1.95437629
58	Overlapping toe (HP:0001845)	1.94954416
59	Shoulder girdle muscle weakness (HP:0003547)	1.93566651
60	Humeroradial synostosis (HP:0003041)	1.92984501
61	Synostosis involving the elbow (HP:0003938)	1.92984501
62	Abnormal gallbladder physiology (HP:0012438)	1.91421107
63	Cholecystitis (HP:0001082)	1.91421107
64	Abnormal delivery (HP:0001787)	1.90857938
65	Breech presentation (HP:0001623)	1.90820434
66	Unilateral renal agenesis (HP:0000122)	1.90401831
67	Calcaneovalgus deformity (HP:0001848)	1.90199612
68	Hypoplastic pelvis (HP:0008839)	1.88270129
69	Increased muscle lipid content (HP:0009058)	1.87236645
70	Acanthocytosis (HP:0001927)	1.85791137
71	Abnormality of pain sensation (HP:0010832)	1.85482516
72	Impaired pain sensation (HP:0007328)	1.85482516
73	Myelomeningocele (HP:0002475)	1.84473942
74	Gonadotropin excess (HP:0000837)	1.83427274
75	Disinhibition (HP:0000734)	1.82169048
76	Nonimmune hydrops fetalis (HP:0001790)	1.82085086
77	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.81157591
78	Neoplasm of the colon (HP:0100273)	1.81148309
79	Increased mean platelet volume (HP:0011877)	1.80757940
80	Conjugated hyperbilirubinemia (HP:0002908)	1.77685144
81	Beaking of vertebral bodies (HP:0004568)	1.77676095
82	Purpura (HP:0000979)	1.77255323
83	Hypoalphalipoproteinemia (HP:0003233)	1.76418080
84	Capillary hemangiomas (HP:0005306)	1.74237200
85	Broad alveolar ridges (HP:0000187)	1.73534361
86	Aplasia/hypoplasia of the humerus (HP:0006507)	1.71869412
87	Volvulus (HP:0002580)	1.71112589
88	Hyperbilirubinemia (HP:0002904)	1.70115634
89	Cone-rod dystrophy (HP:0000548)	1.69448407
90	Chronic obstructive pulmonary disease (HP:0006510)	1.69045509
91	Obstructive lung disease (HP:0006536)	1.69045509
92	Exercise-induced muscle cramps (HP:0003710)	1.68244943
93	Abnormality of the lower motor neuron (HP:0002366)	1.68118660
94	Cerebral hemorrhage (HP:0001342)	1.67932746
95	Cerebral palsy (HP:0100021)	1.67511486
96	Amyloidosis (HP:0011034)	1.63292715
97	Fasciculations (HP:0002380)	1.62430905
98	Arthropathy (HP:0003040)	1.60919641
99	Postnatal microcephaly (HP:0005484)	1.59915524
100	Lipid accumulation in hepatocytes (HP:0006561)	1.59600981

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	3.90519590
2	TIE1	3.60947922
3	SRPK1	3.48968199
4	RPS6KA4	3.27473989
5	CDK12	2.90139220
6	PBK	2.85019304
7	SCYL2	2.75849177
8	BCKDK	2.66944702
9	BCR	2.53430974
10	NEK1	2.51785083
11	KDR	2.43613151
12	TNIK	2.37959537
13	MKNK1	2.11540625
14	PLK3	2.08005622
15	STK16	1.95758554
16	NEK2	1.90637228
17	NTRK1	1.88182472
18	PLK4	1.74268489
19	ALK	1.71698196
20	MKNK2	1.64210170
21	BMPR1B	1.50579501
22	TRIM28	1.48801473
23	TSSK6	1.45267316
24	TTK	1.44859658
25	NEK9	1.41548387
26	BUB1	1.41511737
27	BRD4	1.36345408
28	LATS1	1.36105375
29	CSNK1G2	1.31546821
30	VRK2	1.24939475
31	CSNK1G3	1.24552490
32	MATK	1.22658006
33	PLK1	1.21843211
34	CDK19	1.19593864
35	CDK7	1.19223607
36	WEE1	1.14647329
37	CSNK1G1	1.13516391
38	CDK6	1.11223441
39	MOS	1.07018716
40	ERBB3	1.06033816
41	FLT3	1.04299398
42	LATS2	1.01818839
43	CSNK1A1L	0.97449684
44	NUAK1	0.96937858
45	CDK8	0.96733627
46	MAP3K12	0.95349882
47	ERBB4	0.94216039
48	VRK1	0.92866879
49	EIF2AK3	0.89078005
50	DYRK3	0.86307775
51	DAPK1	0.84159113
52	ZAK	0.83850399
53	ATR	0.82743194
54	PLK2	0.82635740
55	PAK4	0.80007088
56	CDK4	0.78234538
57	SIK3	0.78150850
58	AURKB	0.74481517
59	STK3	0.72680807
60	STK24	0.72468043
61	CDK18	0.70387531
62	BRSK2	0.70028301
63	MAP3K11	0.69900898
64	CDK11A	0.69281446
65	AURKA	0.67816712
66	PDGFRA	0.67808342
67	PNCK	0.67564936
68	FGR	0.66800977
69	CDK14	0.64433857
70	CDK15	0.63244001
71	GRK7	0.60448416
72	ABL2	0.59495098
73	CSNK2A2	0.58046818
74	CHEK2	0.57569476
75	CSNK1D	0.57391477
76	CHEK1	0.57164507
77	EIF2AK1	0.57071509
78	DYRK1B	0.56240183
79	CSNK2A1	0.56171644
80	MAP2K7	0.54541649
81	ATM	0.54272137
82	CSNK1E	0.53759269
83	MAP4K2	0.53399479
84	CDK9	0.53377168
85	TGFBR2	0.50456078
86	YES1	0.48982471
87	BMPR2	0.48722485
88	CSF1R	0.45732868
89	STK38L	0.42875439
90	CDK2	0.40818997
91	CDK1	0.40700883
92	EIF2AK2	0.39343425
93	RIPK1	0.38404437
94	PIK3CG	0.37987139
95	FGFR1	0.36815313
96	EGFR	0.34517746
97	RPS6KA5	0.32828938
98	PDK2	0.29021475
99	IGF1R	0.27506518
100	PRKACB	0.27362266

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	2.73976924
2	Proteasome_Homo sapiens_hsa03050	2.63647136
3	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.53936951
4	Spliceosome_Homo sapiens_hsa03040	2.50893695
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.44492305
6	Mismatch repair_Homo sapiens_hsa03430	2.39454911
7	Steroid biosynthesis_Homo sapiens_hsa00100	2.39085314
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.38499586
9	Complement and coagulation cascades_Homo sapiens_hsa04610	2.24306850
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.13539678
11	Base excision repair_Homo sapiens_hsa03410	2.09684409
12	Protein export_Homo sapiens_hsa03060	2.08877303
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.97004808
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.92786099
15	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.91964199
16	Propanoate metabolism_Homo sapiens_hsa00640	1.86097072
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.85150170
18	Fatty acid elongation_Homo sapiens_hsa00062	1.83654388
19	One carbon pool by folate_Homo sapiens_hsa00670	1.78415370
20	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.75213867
21	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.72714284
22	Carbon metabolism_Homo sapiens_hsa01200	1.72166892
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.71042593
24	RNA transport_Homo sapiens_hsa03013	1.69277541
25	Pyruvate metabolism_Homo sapiens_hsa00620	1.67670621
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.62156181
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.60286013
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.59876012
29	Peroxisome_Homo sapiens_hsa04146	1.59329370
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.53235733
31	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.51127018
32	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.41626882
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.41255117
34	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.31224230
35	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.29329958
36	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.25915683
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24102950
38	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.22804761
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.22109089
40	Cell cycle_Homo sapiens_hsa04110	1.21857875
41	Fatty acid degradation_Homo sapiens_hsa00071	1.21331231
42	Fatty acid metabolism_Homo sapiens_hsa01212	1.20584556
43	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.20048884
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.17605586
45	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.16367529
46	Pyrimidine metabolism_Homo sapiens_hsa00240	1.15234893
47	RNA polymerase_Homo sapiens_hsa03020	1.08737027
48	Retinol metabolism_Homo sapiens_hsa00830	1.07387589
49	Glutathione metabolism_Homo sapiens_hsa00480	1.06769095
50	Pentose phosphate pathway_Homo sapiens_hsa00030	1.05711166
51	Sulfur relay system_Homo sapiens_hsa04122	1.04085080
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.03782712
53	Folate biosynthesis_Homo sapiens_hsa00790	1.02638908
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01576125
55	Butanoate metabolism_Homo sapiens_hsa00650	1.00261528
56	Arginine and proline metabolism_Homo sapiens_hsa00330	0.99106180
57	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.98678127
58	mRNA surveillance pathway_Homo sapiens_hsa03015	0.95424780
59	Asthma_Homo sapiens_hsa05310	0.93105880
60	Sulfur metabolism_Homo sapiens_hsa00920	0.88559305
61	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.87543663
62	Homologous recombination_Homo sapiens_hsa03440	0.86283661
63	Galactose metabolism_Homo sapiens_hsa00052	0.85661996
64	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.84984834
65	Other glycan degradation_Homo sapiens_hsa00511	0.84489579
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84269371
67	RNA degradation_Homo sapiens_hsa03018	0.81734079
68	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.74994312
69	Legionellosis_Homo sapiens_hsa05134	0.72609426
70	Tryptophan metabolism_Homo sapiens_hsa00380	0.72061878
71	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.69930740
72	Antigen processing and presentation_Homo sapiens_hsa04612	0.67096921
73	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.62872773
74	Metabolic pathways_Homo sapiens_hsa01100	0.59830967
75	PPAR signaling pathway_Homo sapiens_hsa03320	0.58732883
76	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.57416047
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51786497
78	Purine metabolism_Homo sapiens_hsa00230	0.50217490
79	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.49660959
80	Fanconi anemia pathway_Homo sapiens_hsa03460	0.48811251
81	Renin-angiotensin system_Homo sapiens_hsa04614	0.47136964
82	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.46473684
83	p53 signaling pathway_Homo sapiens_hsa04115	0.46135916
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.43997757
85	Allograft rejection_Homo sapiens_hsa05330	0.42306887
86	Caffeine metabolism_Homo sapiens_hsa00232	0.42299945
87	Graft-versus-host disease_Homo sapiens_hsa05332	0.42274609
88	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.40715060
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.39827674
90	Salmonella infection_Homo sapiens_hsa05132	0.38692042
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37775111
92	Tyrosine metabolism_Homo sapiens_hsa00350	0.36814019
93	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.36470438
94	Oocyte meiosis_Homo sapiens_hsa04114	0.36401318
95	Phenylalanine metabolism_Homo sapiens_hsa00360	0.35851369
96	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.33326669
97	Lysosome_Homo sapiens_hsa04142	0.31682910
98	Lysine degradation_Homo sapiens_hsa00310	0.30368449
99	Viral myocarditis_Homo sapiens_hsa05416	0.30195981
100	Shigellosis_Homo sapiens_hsa05131	0.27055219

RHEBP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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