RHNO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.40563298
2kinetochore organization (GO:0051383)4.39757340
3telomere maintenance via semi-conservative replication (GO:0032201)4.37464323
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.34901596
5DNA strand elongation involved in DNA replication (GO:0006271)4.26926142
6mitotic metaphase plate congression (GO:0007080)4.24775246
7CENP-A containing nucleosome assembly (GO:0034080)4.13118046
8DNA strand elongation (GO:0022616)4.11742856
9kinetochore assembly (GO:0051382)4.07089519
10chromatin remodeling at centromere (GO:0031055)4.02698564
11telomere maintenance via recombination (GO:0000722)4.02233288
12metaphase plate congression (GO:0051310)3.91724057
13mitotic recombination (GO:0006312)3.90040598
14DNA replication initiation (GO:0006270)3.88925105
15DNA double-strand break processing (GO:0000729)3.87737782
16protein localization to kinetochore (GO:0034501)3.75260689
17telomere maintenance via telomere lengthening (GO:0010833)3.71004739
18establishment of chromosome localization (GO:0051303)3.70480238
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.67406105
20DNA replication checkpoint (GO:0000076)3.67112748
21DNA deamination (GO:0045006)3.63256932
22DNA replication-independent nucleosome organization (GO:0034724)3.61954329
23DNA replication-independent nucleosome assembly (GO:0006336)3.61954329
24meiotic chromosome segregation (GO:0045132)3.61886937
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.61837725
26attachment of spindle microtubules to kinetochore (GO:0008608)3.61694932
27protein localization to chromosome, centromeric region (GO:0071459)3.55458714
28maturation of SSU-rRNA (GO:0030490)3.53433114
29mitotic sister chromatid segregation (GO:0000070)3.49469269
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.45964211
31nucleotide-excision repair, DNA gap filling (GO:0006297)3.45349961
32DNA unwinding involved in DNA replication (GO:0006268)3.43019012
33DNA ligation (GO:0006266)3.40409294
34chaperone-mediated protein transport (GO:0072321)3.29091231
35regulation of mitotic spindle organization (GO:0060236)3.28308066
36histone exchange (GO:0043486)3.28237065
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.24539729
38ATP synthesis coupled proton transport (GO:0015986)3.24539729
39replication fork processing (GO:0031297)3.22281539
40DNA strand renaturation (GO:0000733)3.22178295
41regulation of double-strand break repair via homologous recombination (GO:0010569)3.22079674
42regulation of mitochondrial translation (GO:0070129)3.21984483
43microtubule depolymerization (GO:0007019)3.21134075
44spindle checkpoint (GO:0031577)3.21060824
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20009455
46sister chromatid segregation (GO:0000819)3.18852314
47resolution of meiotic recombination intermediates (GO:0000712)3.18829098
48mitotic chromosome condensation (GO:0007076)3.17595166
49negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16363510
50negative regulation of sister chromatid segregation (GO:0033046)3.16363510
51negative regulation of mitotic sister chromatid separation (GO:2000816)3.16363510
52negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16363510
53ribosomal large subunit biogenesis (GO:0042273)3.14988815
54negative regulation of chromosome segregation (GO:0051985)3.12226928
55spindle assembly checkpoint (GO:0071173)3.11006896
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.07742806
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07680110
58telomere maintenance (GO:0000723)3.07112725
59regulation of nuclear cell cycle DNA replication (GO:0033262)3.06947218
60viral transcription (GO:0019083)3.06556004
61telomere organization (GO:0032200)3.05289263
62establishment of viral latency (GO:0019043)3.04558119
63mitotic spindle assembly checkpoint (GO:0007094)3.04484461
64viral mRNA export from host cell nucleus (GO:0046784)3.04277070
65DNA topological change (GO:0006265)3.03058747
66mitochondrial respiratory chain complex assembly (GO:0033108)3.02865047
67protein complex biogenesis (GO:0070271)3.02727501
68spliceosomal snRNP assembly (GO:0000387)3.00976330
69positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00231810
70regulation of spindle organization (GO:0090224)3.00198655
71mitochondrial respiratory chain complex I assembly (GO:0032981)2.99910107
72NADH dehydrogenase complex assembly (GO:0010257)2.99910107
73mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99910107
74transcription-coupled nucleotide-excision repair (GO:0006283)2.99561665
75mitotic spindle checkpoint (GO:0071174)2.99503160
76DNA damage response, detection of DNA damage (GO:0042769)2.98290705
77translational termination (GO:0006415)2.97524225
78nucleobase biosynthetic process (GO:0046112)2.97060572
79protein K6-linked ubiquitination (GO:0085020)2.96754184
80spliceosomal complex assembly (GO:0000245)2.96705790
81regulation of mitotic metaphase/anaphase transition (GO:0030071)2.95697338
82DNA catabolic process, exonucleolytic (GO:0000738)2.91986658
83regulation of sister chromatid cohesion (GO:0007063)2.91743163
84ribosomal small subunit biogenesis (GO:0042274)2.91654371
85positive regulation of chromosome segregation (GO:0051984)2.90940019
86negative regulation of ligase activity (GO:0051352)2.90526718
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90526718
88regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.89457123
89regulation of centriole replication (GO:0046599)2.88553007
90mismatch repair (GO:0006298)2.87630650
91cullin deneddylation (GO:0010388)2.87529786
92IMP biosynthetic process (GO:0006188)2.87464582
93ribonucleoprotein complex biogenesis (GO:0022613)2.86483838
94L-serine metabolic process (GO:0006563)2.85377593
95regulation of sister chromatid segregation (GO:0033045)2.84981992
96regulation of mitotic sister chromatid separation (GO:0010965)2.84981992
97regulation of mitotic sister chromatid segregation (GO:0033047)2.84981992
98somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84946047
99somatic hypermutation of immunoglobulin genes (GO:0016446)2.84946047
100proteasome assembly (GO:0043248)2.84600432
101regulation of chromosome segregation (GO:0051983)2.84345031
102transcription elongation from RNA polymerase III promoter (GO:0006385)2.84215188
103termination of RNA polymerase III transcription (GO:0006386)2.84215188
104mitotic nuclear envelope disassembly (GO:0007077)2.83933101
105protein K11-linked ubiquitination (GO:0070979)2.82959483
106negative regulation of mitosis (GO:0045839)2.82796108
107centriole replication (GO:0007099)2.82434134
108nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81978257
109intra-S DNA damage checkpoint (GO:0031573)2.81847606
110purine nucleobase biosynthetic process (GO:0009113)2.79629257
111pseudouridine synthesis (GO:0001522)2.79433787
112DNA replication-dependent nucleosome organization (GO:0034723)2.78713971
113DNA replication-dependent nucleosome assembly (GO:0006335)2.78713971
114RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78702510
115tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78702510
116chromosome segregation (GO:0007059)2.77824301
117protein localization to chromosome (GO:0034502)2.77301771
118ATP-dependent chromatin remodeling (GO:0043044)2.76866039
119DNA synthesis involved in DNA repair (GO:0000731)2.75201168
120ribosome biogenesis (GO:0042254)2.74555976
121anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73728184
122rRNA processing (GO:0006364)2.72195942
123maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.70585995
124DNA-dependent DNA replication (GO:0006261)2.69350951
125exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.69033939
126translational elongation (GO:0006414)2.68871027
127regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.68399705
128histone H2A acetylation (GO:0043968)2.68312246
129base-excision repair (GO:0006284)2.66572345
130negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.65660981
131SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64973743
132rRNA metabolic process (GO:0016072)2.64973725
133RNA splicing, via transesterification reactions (GO:0000375)2.63306816
134DNA replication (GO:0006260)2.62856679
135establishment of integrated proviral latency (GO:0075713)2.62642914
136regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.62239772
137regulation of mitotic spindle checkpoint (GO:1903504)2.62239772
138maturation of 5.8S rRNA (GO:0000460)2.62063806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.46299564
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.78619751
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.27461720
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.92269616
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.88580601
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59370287
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.11608215
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90454985
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.80297061
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78768818
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71093083
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69150754
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68802290
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62369156
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58924748
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.58646840
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45471146
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.31434404
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26309096
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25900381
21VDR_23849224_ChIP-Seq_CD4+_Human2.24906869
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23736480
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23550641
24XRN2_22483619_ChIP-Seq_HELA_Human2.17103587
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16466127
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13759241
27TP63_19390658_ChIP-ChIP_HaCaT_Human2.10867733
28FOXP3_21729870_ChIP-Seq_TREG_Human2.10007410
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07507489
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06192751
31E2F1_21310950_ChIP-Seq_MCF-7_Human2.05941202
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05861599
33DCP1A_22483619_ChIP-Seq_HELA_Human1.99831787
34ZNF274_21170338_ChIP-Seq_K562_Hela1.96654448
35TTF2_22483619_ChIP-Seq_HELA_Human1.94142514
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89055973
37ELK1_19687146_ChIP-ChIP_HELA_Human1.88714671
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82671924
39CIITA_25753668_ChIP-Seq_RAJI_Human1.82547777
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82186240
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76224845
42AR_21909140_ChIP-Seq_LNCAP_Human1.75794347
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75726763
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74785494
45GABP_19822575_ChIP-Seq_HepG2_Human1.72964995
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70660190
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68700275
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63528339
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.62825038
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60899907
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.57145530
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.55385158
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55194987
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54119316
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53199758
56IGF1R_20145208_ChIP-Seq_DFB_Human1.52688338
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48505329
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46977931
59EWS_26573619_Chip-Seq_HEK293_Human1.46456684
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42622541
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40802824
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40255777
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38258485
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36750397
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.34798482
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.34003529
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31174733
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30125169
69VDR_22108803_ChIP-Seq_LS180_Human1.29834165
70MYC_18940864_ChIP-ChIP_HL60_Human1.26128851
71MYC_22102868_ChIP-Seq_BL_Human1.20316408
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19920354
73KDM5A_27292631_Chip-Seq_BREAST_Human1.19699098
74FUS_26573619_Chip-Seq_HEK293_Human1.19023795
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18003500
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14733256
77SPI1_23547873_ChIP-Seq_NB4_Human1.14008997
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13643882
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10893386
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09993621
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08728054
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06834885
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05167566
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02431161
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98486824
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92587237
87TAF15_26573619_Chip-Seq_HEK293_Human0.86566126
88TFEB_21752829_ChIP-Seq_HELA_Human0.86071156
89VDR_21846776_ChIP-Seq_THP-1_Human0.82783100
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81926409
91STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81107368
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80948413
93IRF1_19129219_ChIP-ChIP_H3396_Human0.79489435
94TP53_22573176_ChIP-Seq_HFKS_Human0.79099709
95POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76965640
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75973379
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.75616879
98SCL_19346495_ChIP-Seq_HPC-7_Human0.75468197
99MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.75064032
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.74870222
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74808282
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.73147293
103KLF4_18555785_ChIP-Seq_MESCs_Mouse0.72611810
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.72343975
105SOX17_20123909_ChIP-Seq_XEN_Mouse0.71937951
106CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.71652559
107POU5F1_16153702_ChIP-ChIP_HESCs_Human0.70865957
108ZFP57_27257070_Chip-Seq_ESCs_Mouse0.70399929
109FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69659977
110CTBP1_25329375_ChIP-Seq_LNCAP_Human0.69170069
111CTBP2_25329375_ChIP-Seq_LNCAP_Human0.69100912
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.68919562
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.68752392
114CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.68102929
115MYB_26560356_Chip-Seq_TH2_Human0.66087904
116PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.66055509
117MYB_26560356_Chip-Seq_TH1_Human0.66035090
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.65739060
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.65575588
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65101188
121SALL1_21062744_ChIP-ChIP_HESCs_Human0.64905595
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.63618228
123NANOG_16153702_ChIP-ChIP_HESCs_Human0.62493688
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.62046539
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.61807636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.58485688
2MP0010094_abnormal_chromosome_stability4.20907336
3MP0003111_abnormal_nucleus_morphology4.03070427
4MP0003077_abnormal_cell_cycle3.49358897
5MP0004957_abnormal_blastocyst_morpholog3.31833853
6MP0008058_abnormal_DNA_repair3.24788770
7MP0008057_abnormal_DNA_replication3.12105045
8MP0008007_abnormal_cellular_replicative3.00797221
9MP0001529_abnormal_vocalization2.60943237
10MP0003136_yellow_coat_color2.53167241
11MP0002396_abnormal_hematopoietic_system2.49455714
12MP0006292_abnormal_olfactory_placode2.27880056
13MP0008932_abnormal_embryonic_tissue2.21303189
14MP0008877_abnormal_DNA_methylation2.19192327
15MP0008789_abnormal_olfactory_epithelium1.95808921
16MP0000490_abnormal_crypts_of1.94456084
17MP0003786_premature_aging1.91425274
18MP0003123_paternal_imprinting1.85691216
19MP0003763_abnormal_thymus_physiology1.79435620
20MP0000372_irregular_coat_pigmentation1.74448263
21MP0003121_genomic_imprinting1.72426245
22MP0004808_abnormal_hematopoietic_stem1.68765724
23MP0006054_spinal_hemorrhage1.65594342
24MP0000015_abnormal_ear_pigmentation1.60422515
25MP0009379_abnormal_foot_pigmentation1.56177192
26MP0006072_abnormal_retinal_apoptosis1.54187957
27MP0000566_synostosis1.51259322
28MP0000350_abnormal_cell_proliferation1.51155473
29MP0004147_increased_porphyrin_level1.51151586
30MP0005394_taste/olfaction_phenotype1.49576845
31MP0005499_abnormal_olfactory_system1.49576845
32MP0010030_abnormal_orbit_morphology1.48025811
33MP0005174_abnormal_tail_pigmentation1.44590878
34MP0009333_abnormal_splenocyte_physiolog1.36658218
35MP0002095_abnormal_skin_pigmentation1.35889379
36MP0003941_abnormal_skin_development1.34243467
37MP0002102_abnormal_ear_morphology1.31144217
38MP0002132_abnormal_respiratory_system1.30463775
39MP0005075_abnormal_melanosome_morpholog1.29612109
40MP0003787_abnormal_imprinting1.29443361
41MP0000313_abnormal_cell_death1.28031875
42MP0006035_abnormal_mitochondrial_morpho1.27621899
43MP0001730_embryonic_growth_arrest1.26577659
44MP0002398_abnormal_bone_marrow1.26318087
45MP0003315_abnormal_perineum_morphology1.25991637
46MP0002234_abnormal_pharynx_morphology1.24689837
47MP0002210_abnormal_sex_determination1.23454022
48MP0002822_catalepsy1.23433366
49MP0000703_abnormal_thymus_morphology1.22931944
50MP0002019_abnormal_tumor_incidence1.22805434
51MP0002653_abnormal_ependyma_morphology1.22273760
52MP0005187_abnormal_penis_morphology1.22171539
53MP0002938_white_spotting1.19274938
54MP0002736_abnormal_nociception_after1.19243450
55MP0000778_abnormal_nervous_system1.18641076
56MP0001672_abnormal_embryogenesis/_devel1.18392469
57MP0005380_embryogenesis_phenotype1.18392469
58MP0001697_abnormal_embryo_size1.14626113
59MP0003718_maternal_effect1.14392830
60MP0001188_hyperpigmentation1.13408643
61MP0001984_abnormal_olfaction1.12872168
62MP0004133_heterotaxia1.12714572
63MP0002233_abnormal_nose_morphology1.12665033
64MP0000647_abnormal_sebaceous_gland1.12445408
65MP0000631_abnormal_neuroendocrine_gland1.12319767
66MP0002722_abnormal_immune_system1.10745576
67MP0003567_abnormal_fetal_cardiomyocyte1.09344395
68MP0001119_abnormal_female_reproductive1.08933342
69MP0002638_abnormal_pupillary_reflex1.07682759
70MP0000689_abnormal_spleen_morphology1.07405049
71MP0002085_abnormal_embryonic_tissue1.05984507
72MP0005397_hematopoietic_system_phenotyp1.05785369
73MP0001545_abnormal_hematopoietic_system1.05785369
74MP0005171_absent_coat_pigmentation1.05764067
75MP0003186_abnormal_redox_activity1.05742049
76MP0001293_anophthalmia1.05497301
77MP0000049_abnormal_middle_ear1.04928396
78MP0005253_abnormal_eye_physiology1.04373431
79MP0002697_abnormal_eye_size1.00876624
80MP0001986_abnormal_taste_sensitivity1.00178814
81MP0002080_prenatal_lethality1.00173528
82MP0005671_abnormal_response_to0.98441573
83MP0001145_abnormal_male_reproductive0.98226613
84MP0001346_abnormal_lacrimal_gland0.97779088
85MP0001835_abnormal_antigen_presentation0.97765196
86MP0003984_embryonic_growth_retardation0.97707576
87MP0010307_abnormal_tumor_latency0.97404086
88MP0000858_altered_metastatic_potential0.97382949
89MP0005084_abnormal_gallbladder_morpholo0.96621241
90MP0005391_vision/eye_phenotype0.96014160
91MP0002160_abnormal_reproductive_system0.95671969
92MP0002429_abnormal_blood_cell0.95355443
93MP0002088_abnormal_embryonic_growth/wei0.95321095
94MP0000358_abnormal_cell_content/0.95033987
95MP0003861_abnormal_nervous_system0.94712866
96MP0006036_abnormal_mitochondrial_physio0.94231575
97MP0004142_abnormal_muscle_tone0.93230268
98MP0001929_abnormal_gametogenesis0.92823609
99MP0000716_abnormal_immune_system0.91526538
100MP0003755_abnormal_palate_morphology0.91060668
101MP0001727_abnormal_embryo_implantation0.89916381
102MP0005551_abnormal_eye_electrophysiolog0.89795645
103MP0003937_abnormal_limbs/digits/tail_de0.89389395
104MP0002420_abnormal_adaptive_immunity0.89248658
105MP0003938_abnormal_ear_development0.89020047
106MP0001819_abnormal_immune_cell0.87940203
107MP0001800_abnormal_humoral_immune0.87704618
108MP0000653_abnormal_sex_gland0.87273478
109MP0003943_abnormal_hepatobiliary_system0.86053797
110MP0001324_abnormal_eye_pigmentation0.84435398
111MP0002452_abnormal_antigen_presenting0.83740252
112MP0003698_abnormal_male_reproductive0.83367070
113MP0004742_abnormal_vestibular_system0.82219985
114MP0006276_abnormal_autonomic_nervous0.81938714
115MP0005389_reproductive_system_phenotype0.81663464
116MP0003119_abnormal_digestive_system0.81282330
117MP0001764_abnormal_homeostasis0.79787750
118MP0009697_abnormal_copulation0.79540619
119MP0002086_abnormal_extraembryonic_tissu0.79332473
120MP0002277_abnormal_respiratory_mucosa0.78790382
121MP0002148_abnormal_hypersensitivity_rea0.78193504
122MP0002092_abnormal_eye_morphology0.78177541
123MP0002084_abnormal_developmental_patter0.77618124
124MP0005646_abnormal_pituitary_gland0.77341778
125MP0009785_altered_susceptibility_to0.77324024
126MP0001286_abnormal_eye_development0.77232441
127MP0004197_abnormal_fetal_growth/weight/0.76761819
128MP0000537_abnormal_urethra_morphology0.75477636
129MP0002075_abnormal_coat/hair_pigmentati0.74474601
130MP0005195_abnormal_posterior_eye0.74356785
131MP0009046_muscle_twitch0.73724485
132MP0003890_abnormal_embryonic-extraembry0.73487289
133MP0001919_abnormal_reproductive_system0.73256478
134MP0001186_pigmentation_phenotype0.73016737
135MP0002405_respiratory_system_inflammati0.71765242
136MP0008995_early_reproductive_senescence0.70483050
137MP0002249_abnormal_larynx_morphology0.70100241
138MP0005409_darkened_coat_color0.69549987
139MP0009053_abnormal_anal_canal0.69388013
140MP0002723_abnormal_immune_serum0.69114678
141MP0002163_abnormal_gland_morphology0.68890231
142MP0003942_abnormal_urinary_system0.68499354
143MP0010155_abnormal_intestine_physiology0.68344099
144MP0003122_maternal_imprinting0.67579345
145MP0002111_abnormal_tail_morphology0.66142092
146MP0002751_abnormal_autonomic_nervous0.65384447

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.37059258
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.32803878
3Reticulocytopenia (HP:0001896)4.48808083
4Meckel diverticulum (HP:0002245)3.60521546
5Birth length less than 3rd percentile (HP:0003561)3.49424555
6Abnormality of the ileum (HP:0001549)3.46570906
7Abnormality of the preputium (HP:0100587)3.44966356
8Abnormality of chromosome stability (HP:0003220)3.40845024
9Abnormality of the labia minora (HP:0012880)3.37485151
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.28089740
11Aplastic anemia (HP:0001915)3.27375607
12Duplicated collecting system (HP:0000081)3.26024395
13Abnormal number of erythroid precursors (HP:0012131)3.23079117
14Acute necrotizing encephalopathy (HP:0006965)3.20033975
15Abnormality of cells of the erythroid lineage (HP:0012130)3.14584953
1611 pairs of ribs (HP:0000878)3.06883649
17Duodenal stenosis (HP:0100867)3.01470917
18Small intestinal stenosis (HP:0012848)3.01470917
19Ectopic kidney (HP:0000086)3.01009587
20Abnormal lung lobation (HP:0002101)3.00568282
21Abnormality of the renal collecting system (HP:0004742)2.97775665
22Nephroblastoma (Wilms tumor) (HP:0002667)2.91674100
23Abnormal mitochondria in muscle tissue (HP:0008316)2.89257196
24Patellar aplasia (HP:0006443)2.88349806
25Acute encephalopathy (HP:0006846)2.86485998
26Abnormality of DNA repair (HP:0003254)2.83264112
27Mitochondrial inheritance (HP:0001427)2.82852106
28Myelodysplasia (HP:0002863)2.79124977
29Embryonal renal neoplasm (HP:0011794)2.76052858
30Absent thumb (HP:0009777)2.72431040
31Aplasia/Hypoplasia of the patella (HP:0006498)2.71172950
32Increased CSF lactate (HP:0002490)2.68546159
33Cortical dysplasia (HP:0002539)2.68129486
34True hermaphroditism (HP:0010459)2.65504788
35Clubbing of toes (HP:0100760)2.60801406
36Volvulus (HP:0002580)2.60645282
37Pancreatic fibrosis (HP:0100732)2.57151196
38Progressive macrocephaly (HP:0004481)2.55008370
39Bone marrow hypocellularity (HP:0005528)2.53845262
40Increased hepatocellular lipid droplets (HP:0006565)2.52728168
41Oral leukoplakia (HP:0002745)2.52566320
42Pancreatic cysts (HP:0001737)2.48460900
43Abnormality of midbrain morphology (HP:0002418)2.48360968
44Molar tooth sign on MRI (HP:0002419)2.48360968
45Abnormality of the duodenum (HP:0002246)2.44245850
46Triphalangeal thumb (HP:0001199)2.43096698
47Breast hypoplasia (HP:0003187)2.42992748
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37506575
49Abnormal number of incisors (HP:0011064)2.36665174
50Pendular nystagmus (HP:0012043)2.35225304
51Hepatocellular necrosis (HP:0001404)2.35002301
52Premature graying of hair (HP:0002216)2.29582139
53Sloping forehead (HP:0000340)2.29228754
54Lipid accumulation in hepatocytes (HP:0006561)2.28979835
55Hypoplastic pelvis (HP:0008839)2.27678168
56Pallor (HP:0000980)2.25953411
57Spinal cord lesions (HP:0100561)2.25038237
58Syringomyelia (HP:0003396)2.25038237
59Septo-optic dysplasia (HP:0100842)2.25011188
60Abnormality of the anterior horn cell (HP:0006802)2.21843895
61Degeneration of anterior horn cells (HP:0002398)2.21843895
62Colon cancer (HP:0003003)2.18727760
63Abnormality of the carotid arteries (HP:0005344)2.17092270
64Medial flaring of the eyebrow (HP:0010747)2.16696321
65Cerebral edema (HP:0002181)2.13876498
66Hyperglycinemia (HP:0002154)2.13776422
67Type I transferrin isoform profile (HP:0003642)2.11918984
68Rough bone trabeculation (HP:0100670)2.11885816
69Impulsivity (HP:0100710)2.11788490
70Selective tooth agenesis (HP:0001592)2.11518098
71Macrocytic anemia (HP:0001972)2.09802291
72Absent radius (HP:0003974)2.08259859
73Sclerocornea (HP:0000647)2.07144616
74Hepatic necrosis (HP:0002605)2.06903973
75Increased serum lactate (HP:0002151)2.06280746
76Supernumerary spleens (HP:0009799)2.06058285
77Short thumb (HP:0009778)2.05093050
78Tracheoesophageal fistula (HP:0002575)2.03624844
79Optic nerve coloboma (HP:0000588)2.02110371
80Medulloblastoma (HP:0002885)1.97139906
81Congenital primary aphakia (HP:0007707)1.96993896
82Broad distal phalanx of finger (HP:0009836)1.95048979
83Duplication of thumb phalanx (HP:0009942)1.93214387
84Gait imbalance (HP:0002141)1.92875994
85Pancytopenia (HP:0001876)1.91010706
86Methylmalonic acidemia (HP:0002912)1.90306715
87Retinal dysplasia (HP:0007973)1.89540999
88Short middle phalanx of the 5th finger (HP:0004220)1.89442682
89Horseshoe kidney (HP:0000085)1.89299082
90Aplasia involving forearm bones (HP:0009822)1.88908260
91Absent forearm bone (HP:0003953)1.88908260
92B lymphocytopenia (HP:0010976)1.88681482
93Abnormality of B cell number (HP:0010975)1.88681482
94Anophthalmia (HP:0000528)1.88456623
95Anencephaly (HP:0002323)1.88450250
96Abnormality of glycolysis (HP:0004366)1.87839842
97Lymphoma (HP:0002665)1.87839300
98IgM deficiency (HP:0002850)1.87818588
99Aplasia/Hypoplasia of the sternum (HP:0006714)1.86313711
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.86297700
101Increased serum pyruvate (HP:0003542)1.86067209
102Absent septum pellucidum (HP:0001331)1.84609346
103Thrombocytosis (HP:0001894)1.84306351
104Lactic acidosis (HP:0003128)1.83360386
105Astigmatism (HP:0000483)1.83319435
106Type 2 muscle fiber atrophy (HP:0003554)1.82887996
107Oligodactyly (hands) (HP:0001180)1.82498894
108Holoprosencephaly (HP:0001360)1.81933349
109Nephrogenic diabetes insipidus (HP:0009806)1.81557232
110Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.80061112
111Panhypogammaglobulinemia (HP:0003139)1.80054830
112Bilateral microphthalmos (HP:0007633)1.79793783
113Dandy-Walker malformation (HP:0001305)1.79213422
114Nephronophthisis (HP:0000090)1.77688843
115Optic disc pallor (HP:0000543)1.77457681
116Postaxial foot polydactyly (HP:0001830)1.75997003
117Cleft eyelid (HP:0000625)1.75800716
118Cellular immunodeficiency (HP:0005374)1.74768462
119Lissencephaly (HP:0001339)1.73738791
120Poikiloderma (HP:0001029)1.73254676
121Aganglionic megacolon (HP:0002251)1.73004413
122Optic nerve hypoplasia (HP:0000609)1.72766362
123Oligodactyly (HP:0012165)1.72079568
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71833244
125Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71064237
126Renal Fanconi syndrome (HP:0001994)1.69904318
127Muscle fiber atrophy (HP:0100295)1.68578907
128Increased nuchal translucency (HP:0010880)1.68328169
129Neoplasm of the pancreas (HP:0002894)1.67966851
130Severe combined immunodeficiency (HP:0004430)1.63865211
131Asplenia (HP:0001746)1.62796194
132Preaxial hand polydactyly (HP:0001177)1.61835586
133IgG deficiency (HP:0004315)1.61349320
134Microvesicular hepatic steatosis (HP:0001414)1.61347953
135Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.61180791
136Short 4th metacarpal (HP:0010044)1.61180791
137Abnormality of the heme biosynthetic pathway (HP:0010472)1.61094493
138Abnormal trabecular bone morphology (HP:0100671)1.59467071
139Microretrognathia (HP:0000308)1.59384519
140Pulmonary fibrosis (HP:0002206)1.58636264
141Facial cleft (HP:0002006)1.58586640
142Intestinal atresia (HP:0011100)1.58274398
143Deep philtrum (HP:0002002)1.57300956
144Abnormality of the incisor (HP:0000676)1.56566883
145Abnormal protein glycosylation (HP:0012346)1.56247670
146Abnormal glycosylation (HP:0012345)1.56247670
147Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.56247670
148Abnormal protein N-linked glycosylation (HP:0012347)1.56247670
149Abnormal spermatogenesis (HP:0008669)1.56078676
150Carpal bone hypoplasia (HP:0001498)1.55983099
151Missing ribs (HP:0000921)1.55195295
1523-Methylglutaconic aciduria (HP:0003535)1.54953461
153Acute lymphatic leukemia (HP:0006721)1.52301309
154Squamous cell carcinoma (HP:0002860)1.50835749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.55374732
2CDC73.41260806
3WEE13.32502469
4VRK23.30940997
5SRPK12.99750198
6STK162.77909696
7MKNK12.45376221
8NEK22.39999709
9BRSK22.27472393
10PLK42.27171118
11VRK12.24434411
12EIF2AK12.16247675
13TTK1.96272840
14MKNK21.95995656
15CCNB11.90577943
16TRIM281.82468433
17PLK11.82364625
18TLK11.82226983
19WNK31.81073976
20ZAK1.79069535
21CLK11.72838176
22NME21.70964304
23ATR1.70500314
24MAP4K21.67480794
25AURKB1.62848298
26TAF11.62365553
27ACVR1B1.58876250
28CDK71.57518121
29PASK1.54233176
30BRSK11.53103456
31BCKDK1.46962812
32BCR1.45021954
33PLK31.44433109
34RPS6KA41.43275092
35EIF2AK21.42822616
36DYRK31.42069364
37IRAK41.40789664
38TXK1.31764474
39CDK81.30008488
40STK41.25327086
41EIF2AK31.25063951
42MAP2K71.21181526
43CSNK1G31.21035342
44CHEK21.20109582
45MAP4K11.19816025
46TEC1.18610089
47YES11.17055395
48CDK191.16411398
49TGFBR11.12633177
50TSSK61.09882249
51AURKA1.07627545
52TESK21.07184373
53CSNK1G11.06879396
54IRAK31.05550597
55CSNK1A1L1.04983231
56CASK1.04646244
57PIM21.04232654
58CDK41.02082794
59CSNK1G21.01269376
60ERBB31.00471245
61PIM10.98954921
62CHEK10.96434233
63BRD40.95568189
64BRAF0.90137626
65STK100.88482876
66NME10.88383896
67MAP3K140.86409760
68RPS6KB20.86320593
69MAP3K80.85387927
70MST40.84718443
71ATM0.84669538
72BTK0.84175637
73MAP3K40.81856752
74STK38L0.80975666
75TNIK0.80682726
76UHMK10.78022784
77NEK90.77173757
78MINK10.75574379
79BLK0.75120922
80MAPK130.74391274
81SIK30.73377026
82BMPR1B0.71683479
83PLK20.71330609
84NEK10.70445846
85CSNK2A10.68504343
86ADRBK20.67009706
87NLK0.66464223
88CDK30.65664048
89MARK30.64551013
90PAK40.64500265
91CDK120.62790377
92TESK10.61742742
93CDK20.61139507
94CHUK0.60906566
95MELK0.60224631
96LIMK10.60217133
97PBK0.58294477
98STK240.58253658
99RPS6KA50.57699782
100GRK10.55164542
101CDK10.55058616
102PNCK0.53965738
103IKBKB0.52769344
104JAK30.52594750
105TAOK20.52343024
106CDK140.51782305
107RPS6KA60.51762819
108NUAK10.51698090
109DYRK20.51475878
110CDK180.51085380
111RPS6KL10.51028215
112RPS6KC10.51028215
113PIK3CG0.50978598
114FRK0.50907388
115KIT0.49000611
116PRKCG0.48722814
117CDK11A0.47969351
118CDK150.47574530
119FLT30.47304596
120CSNK2A20.47162984
121MAP3K100.47152003
122ZAP700.45695433
123LYN0.42654624
124IKBKE0.41891882
125PRKCI0.41828836
126MAP2K30.41432749
127WNK40.40701333
128STK30.37010373
129PINK10.36723516
130EPHA20.33445997
131CSNK1E0.33401551
132PAK10.33179452
133EPHB20.33064119
134RPS6KB10.33007428
135KDR0.32617935
136MARK10.31874499
137EEF2K0.31799876
138PDK20.29132539
139CSNK1A10.29041722
140PRKDC0.28939041
141PRKCE0.22484202
142CSNK1D0.20959882

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.53674787
2Mismatch repair_Homo sapiens_hsa034303.83263153
3Base excision repair_Homo sapiens_hsa034103.37522377
4Homologous recombination_Homo sapiens_hsa034403.35542120
5Ribosome_Homo sapiens_hsa030103.19110493
6Spliceosome_Homo sapiens_hsa030403.06119908
7RNA polymerase_Homo sapiens_hsa030203.03853975
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.91279834
9Fanconi anemia pathway_Homo sapiens_hsa034602.81578115
10Nucleotide excision repair_Homo sapiens_hsa034202.80021338
11Cell cycle_Homo sapiens_hsa041102.67850951
12Oxidative phosphorylation_Homo sapiens_hsa001902.58673323
13Proteasome_Homo sapiens_hsa030502.50476271
14Non-homologous end-joining_Homo sapiens_hsa034502.44186423
15Pyrimidine metabolism_Homo sapiens_hsa002402.38096783
16RNA transport_Homo sapiens_hsa030132.36986523
17Basal transcription factors_Homo sapiens_hsa030222.07537027
18One carbon pool by folate_Homo sapiens_hsa006702.01602008
19RNA degradation_Homo sapiens_hsa030181.91733859
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88092880
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79677286
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74728895
23mRNA surveillance pathway_Homo sapiens_hsa030151.71816685
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71078250
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61898756
26Steroid biosynthesis_Homo sapiens_hsa001001.61554528
27p53 signaling pathway_Homo sapiens_hsa041151.58135520
28Fatty acid elongation_Homo sapiens_hsa000621.43912520
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41177719
30Primary immunodeficiency_Homo sapiens_hsa053401.40649687
31Alzheimers disease_Homo sapiens_hsa050101.39652757
32Purine metabolism_Homo sapiens_hsa002301.36260315
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.31321463
34Propanoate metabolism_Homo sapiens_hsa006401.26954883
35Herpes simplex infection_Homo sapiens_hsa051681.25161567
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19976693
37Folate biosynthesis_Homo sapiens_hsa007901.17868929
38Epstein-Barr virus infection_Homo sapiens_hsa051691.15517255
39Protein export_Homo sapiens_hsa030601.12160973
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10370207
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07810431
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07761437
43Pyruvate metabolism_Homo sapiens_hsa006201.05170809
44Biosynthesis of amino acids_Homo sapiens_hsa012301.04672481
45HTLV-I infection_Homo sapiens_hsa051660.90213836
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.89629312
47Phototransduction_Homo sapiens_hsa047440.89033780
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87316972
49Systemic lupus erythematosus_Homo sapiens_hsa053220.87223402
50Measles_Homo sapiens_hsa051620.85955171
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85758400
52Butanoate metabolism_Homo sapiens_hsa006500.83911730
53Cardiac muscle contraction_Homo sapiens_hsa042600.81869461
54Antigen processing and presentation_Homo sapiens_hsa046120.81299587
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.78872037
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77396159
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77068780
58Carbon metabolism_Homo sapiens_hsa012000.76488535
59Peroxisome_Homo sapiens_hsa041460.76065885
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74641623
61Viral carcinogenesis_Homo sapiens_hsa052030.74431639
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73961660
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73830951
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73220734
65Oocyte meiosis_Homo sapiens_hsa041140.73187279
66Basal cell carcinoma_Homo sapiens_hsa052170.72975339
67Hematopoietic cell lineage_Homo sapiens_hsa046400.71486616
68Metabolic pathways_Homo sapiens_hsa011000.70364089
69Sulfur relay system_Homo sapiens_hsa041220.70113409
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64559351
71Huntingtons disease_Homo sapiens_hsa050160.63734028
72Legionellosis_Homo sapiens_hsa051340.62935415
73Small cell lung cancer_Homo sapiens_hsa052220.60660450
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59210885
75Apoptosis_Homo sapiens_hsa042100.58314249
76MicroRNAs in cancer_Homo sapiens_hsa052060.56532596
77Hepatitis B_Homo sapiens_hsa051610.55903149
78Allograft rejection_Homo sapiens_hsa053300.55558052
79Thyroid cancer_Homo sapiens_hsa052160.54538717
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54027228
81Arachidonic acid metabolism_Homo sapiens_hsa005900.53563752
82Influenza A_Homo sapiens_hsa051640.53420830
83Fatty acid metabolism_Homo sapiens_hsa012120.52322588
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52311623
85Notch signaling pathway_Homo sapiens_hsa043300.52225765
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52074658
87Nicotine addiction_Homo sapiens_hsa050330.51887358
88N-Glycan biosynthesis_Homo sapiens_hsa005100.50575905
89Shigellosis_Homo sapiens_hsa051310.49358294
90Asthma_Homo sapiens_hsa053100.49155785
91Graft-versus-host disease_Homo sapiens_hsa053320.48864373
92Leishmaniasis_Homo sapiens_hsa051400.48156357
93Colorectal cancer_Homo sapiens_hsa052100.46421571
94Autoimmune thyroid disease_Homo sapiens_hsa053200.46139756
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45956054
96TGF-beta signaling pathway_Homo sapiens_hsa043500.43023628
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42446033
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42060020
99Regulation of autophagy_Homo sapiens_hsa041400.42036576
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40610288
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40539345
102Parkinsons disease_Homo sapiens_hsa050120.40362819
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39688729
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39541506
105beta-Alanine metabolism_Homo sapiens_hsa004100.39197248
106Tryptophan metabolism_Homo sapiens_hsa003800.39040253
107Hippo signaling pathway_Homo sapiens_hsa043900.38832094
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38664542
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.38351232
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37505862
111Pathways in cancer_Homo sapiens_hsa052000.36751096
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36728425
113Other glycan degradation_Homo sapiens_hsa005110.35512328
114Wnt signaling pathway_Homo sapiens_hsa043100.34467867
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34247099
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33824987
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33746150
118Viral myocarditis_Homo sapiens_hsa054160.33376064
119Lysine degradation_Homo sapiens_hsa003100.30635120
120Acute myeloid leukemia_Homo sapiens_hsa052210.30503533
121Nitrogen metabolism_Homo sapiens_hsa009100.30379287
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30032432
123Hedgehog signaling pathway_Homo sapiens_hsa043400.29655283
124T cell receptor signaling pathway_Homo sapiens_hsa046600.29554705
125Chronic myeloid leukemia_Homo sapiens_hsa052200.27891376
126Caffeine metabolism_Homo sapiens_hsa002320.27815835
127Prostate cancer_Homo sapiens_hsa052150.27367140
128B cell receptor signaling pathway_Homo sapiens_hsa046620.27296899
129Vitamin B6 metabolism_Homo sapiens_hsa007500.26235475
130Arginine and proline metabolism_Homo sapiens_hsa003300.26141670
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26019910
132Selenocompound metabolism_Homo sapiens_hsa004500.25845449
133Pentose phosphate pathway_Homo sapiens_hsa000300.24994308
134Alcoholism_Homo sapiens_hsa050340.24872297
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.24072019
136Melanoma_Homo sapiens_hsa052180.23165188
137Pancreatic cancer_Homo sapiens_hsa052120.23131535
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21477792
139Glutathione metabolism_Homo sapiens_hsa004800.21224538
140Toxoplasmosis_Homo sapiens_hsa051450.19548744
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.18861298
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.18839305
143TNF signaling pathway_Homo sapiens_hsa046680.18413365
144Fatty acid degradation_Homo sapiens_hsa000710.18298021
145Malaria_Homo sapiens_hsa051440.18247782
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16404356
147Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16150754
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14553892
149Olfactory transduction_Homo sapiens_hsa047400.13373924
150Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13096244
151Taste transduction_Homo sapiens_hsa047420.10561623
152Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10544495
153Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09524204
154Primary bile acid biosynthesis_Homo sapiens_hsa001200.09320789

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