RHO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal rod cell development (GO:0046548)9.71841915
2positive regulation of guanylate cyclase activity (GO:0031284)9.61250430
3* visual perception (GO:0007601)8.75425642
4regulation of guanylate cyclase activity (GO:0031282)8.69069026
5* sensory perception of light stimulus (GO:0050953)8.65232349
6negative regulation of heart growth (GO:0061117)8.49728929
7negative regulation of cardiac muscle tissue growth (GO:0055022)8.49728929
8negative regulation of cardiac muscle hypertrophy (GO:0010614)8.25382583
9negative regulation of muscle hypertrophy (GO:0014741)7.39782081
10* cellular response to light stimulus (GO:0071482)7.27605241
11* detection of external stimulus (GO:0009581)7.07745794
12response to electrical stimulus (GO:0051602)6.96275197
13* detection of abiotic stimulus (GO:0009582)6.93480910
14eye photoreceptor cell differentiation (GO:0001754)6.91442030
15photoreceptor cell differentiation (GO:0046530)6.91442030
16* protein-chromophore linkage (GO:0018298)6.89926133
17regulation of cGMP metabolic process (GO:0030823)6.39377454
18* retina development in camera-type eye (GO:0060041)5.89851685
19fat-soluble vitamin metabolic process (GO:0006775)5.69748943
20positive regulation of cGMP biosynthetic process (GO:0030828)5.63200891
21negative regulation of cardiac muscle tissue development (GO:0055026)5.61307171
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.61257614
23retinal metabolic process (GO:0042574)5.47043088
24detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)5.40444924
25regulation of cGMP biosynthetic process (GO:0030826)5.28981674
26positive regulation of cGMP metabolic process (GO:0030825)4.96626176
27adaptation of signaling pathway (GO:0023058)4.89954911
28positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.79730643
29regulation of cardiac muscle cell differentiation (GO:2000725)4.75391832
30sensory perception of taste (GO:0050909)4.71609299
31receptor guanylyl cyclase signaling pathway (GO:0007168)4.67252809
32cell morphogenesis involved in neuron differentiation (GO:0048667)4.66549665
33* cellular response to radiation (GO:0071478)4.66177853
34nonmotile primary cilium assembly (GO:0035058)4.59692288
35regulation of clathrin-mediated endocytosis (GO:2000369)4.45868045
36keratan sulfate catabolic process (GO:0042340)4.27682560
37estrogen biosynthetic process (GO:0006703)4.22384130
38* regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.15173682
39protein prenylation (GO:0018342)4.12269627
40prenylation (GO:0097354)4.12269627
41* sensory perception (GO:0007600)4.09652075
42regulation of voltage-gated calcium channel activity (GO:1901385)4.07740217
43retina layer formation (GO:0010842)3.89300127
44* response to light stimulus (GO:0009416)3.86970028
45negative regulation of striated muscle cell differentiation (GO:0051154)3.82304542
46regulation of cardiac muscle hypertrophy (GO:0010611)3.70959093
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.65201913
48neuron development (GO:0048666)3.61869721
49regulation of short-term neuronal synaptic plasticity (GO:0048172)3.60825646
50retina homeostasis (GO:0001895)3.58497923
51regulation of muscle hypertrophy (GO:0014743)3.56085703
52CDP-diacylglycerol biosynthetic process (GO:0016024)3.54258234
53negative regulation of receptor-mediated endocytosis (GO:0048261)3.39375345
54short-term memory (GO:0007614)3.38380102
55protein localization to synapse (GO:0035418)3.34342126
56negative regulation of organ growth (GO:0046621)3.29864299
57positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.29409038
58positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.27640553
59chemosensory behavior (GO:0007635)3.25511646
60CDP-diacylglycerol metabolic process (GO:0046341)3.25448495
61positive regulation of neurotransmitter transport (GO:0051590)3.23379539
62membrane hyperpolarization (GO:0060081)3.21674348
63behavioral response to ethanol (GO:0048149)3.20773443
64regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.18020886
65regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.18020886
66cellular response to zinc ion (GO:0071294)3.13624274
67regulation of penile erection (GO:0060405)3.12945463
68synaptic vesicle maturation (GO:0016188)3.08106015
69response to histamine (GO:0034776)3.08042257
70positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.07645160
71* terpenoid metabolic process (GO:0006721)3.06377454
72detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.03900621
73positive regulation of sodium ion transmembrane transport (GO:1902307)3.03663579
74lipid translocation (GO:0034204)3.02695442
75phospholipid translocation (GO:0045332)3.02695442
76vitamin A metabolic process (GO:0006776)23.2948900
77peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.94472290
78synaptic vesicle docking involved in exocytosis (GO:0016081)2.91152124
79positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.87823556
80positive regulation of lyase activity (GO:0051349)2.86231655
81negative regulation of striated muscle tissue development (GO:0045843)2.81935725
82regulation of muscle adaptation (GO:0043502)2.81390540
83detection of chemical stimulus involved in sensory perception (GO:0050907)2.79144163
84* retinoid metabolic process (GO:0001523)2.71872363
85negative regulation of muscle tissue development (GO:1901862)2.71565998
86post-embryonic morphogenesis (GO:0009886)2.68855067
87positive regulation of ERBB signaling pathway (GO:1901186)2.68135273
88negative regulation of cation channel activity (GO:2001258)2.67413373
89lipoprotein transport (GO:0042953)2.66861547
90icosanoid secretion (GO:0032309)2.64470761
91arachidonic acid secretion (GO:0050482)2.64470761
92* response to radiation (GO:0009314)2.63710233
93negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.62970867
94negative regulation of calcium ion transmembrane transport (GO:1903170)2.62970867
95dopamine receptor signaling pathway (GO:0007212)2.62377641
96negative regulation of muscle organ development (GO:0048635)2.62277096
97primary alcohol metabolic process (GO:0034308)2.61590416
98negative regulation of catenin import into nucleus (GO:0035414)2.60996468
99axoneme assembly (GO:0035082)2.57044074
100retinol metabolic process (GO:0042572)2.55890793
101regulation of cardiac muscle tissue growth (GO:0055021)2.54438163
102* diterpenoid metabolic process (GO:0016101)2.52525742
103negative regulation of transcription regulatory region DNA binding (GO:2000678)2.49150782
104behavioral response to cocaine (GO:0048148)2.48080249
105* isoprenoid metabolic process (GO:0006720)2.47450504
106barbed-end actin filament capping (GO:0051016)2.43527598
107righting reflex (GO:0060013)2.42817526
108vasculature development (GO:0001944)2.40799933
109positive regulation of cyclase activity (GO:0031281)2.40382776
110establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.40059628
111mitochondrion transport along microtubule (GO:0047497)2.40059628
112synaptic transmission, dopaminergic (GO:0001963)2.38141685
113cellular potassium ion homeostasis (GO:0030007)2.37909822
114* cellular response to abiotic stimulus (GO:0071214)2.35557973
115extracellular fibril organization (GO:0043206)2.34979855
116low-density lipoprotein particle remodeling (GO:0034374)2.34803885
117negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.34715007
118protein heterotetramerization (GO:0051290)2.33243717
119smooth muscle tissue development (GO:0048745)2.32798057
120cellular response to cadmium ion (GO:0071276)2.30769215
121regulation of lipoprotein metabolic process (GO:0050746)2.29743752
122regulation of cytokine production involved in inflammatory response (GO:1900015)2.26937239
123quaternary ammonium group transport (GO:0015697)2.19528958
124negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.18721869
125regulation of heart growth (GO:0060420)2.15156610
126regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.11739716
127muscle filament sliding (GO:0030049)2.11107804
128actin-myosin filament sliding (GO:0033275)2.11107804
129modified amino acid transport (GO:0072337)2.10781304
130sensory perception of chemical stimulus (GO:0007606)2.09907843
131lymph vessel development (GO:0001945)2.09095607
132negative regulation of muscle cell differentiation (GO:0051148)2.06772254
133cell-cell junction maintenance (GO:0045217)2.04142590
134negative regulation of developmental growth (GO:0048640)2.03860499
135gamma-aminobutyric acid transport (GO:0015812)2.00867886
136cellular response to electrical stimulus (GO:0071257)17.9923794
137* regulation of rhodopsin mediated signaling pathway (GO:0022400)17.8363495
138* rhodopsin mediated signaling pathway (GO:0016056)17.5884716
139retinal cone cell development (GO:0046549)15.4937927
140photoreceptor cell development (GO:0042461)12.3089726
141photoreceptor cell maintenance (GO:0045494)11.8224749
142eye photoreceptor cell development (GO:0042462)11.6405130
143detection of light stimulus involved in visual perception (GO:0050908)11.4263971
144detection of light stimulus involved in sensory perception (GO:0050962)11.4263971
145* phototransduction (GO:0007602)10.7375244
146* phototransduction, visible light (GO:0007603)10.6337171
147GMP metabolic process (GO:0046037)10.1358498
148* detection of light stimulus (GO:0009583)10.1330641
149* detection of visible light (GO:0009584)10.1182310
150regulation of cyclase activity (GO:0031279)1.99030251
151positive regulation of cyclic nucleotide biosynthetic process (GO:0030804)1.95053387
152fibril organization (GO:0097435)1.94722507
153keratan sulfate biosynthetic process (GO:0018146)1.94527561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_26923725_Chip-Seq_HPCs_Mouse5.85894935
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse5.07546442
3CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.28895132
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.19386772
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.16577324
6VDR_22108803_ChIP-Seq_LS180_Human2.81601966
7GBX2_23144817_ChIP-Seq_PC3_Human2.53180955
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.44744205
9DROSHA_22980978_ChIP-Seq_HELA_Human2.36162684
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.17883798
11DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.15422870
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07352726
13BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.06817251
14TRIM28_21343339_ChIP-Seq_HEK293_Human1.98366327
15AR_21572438_ChIP-Seq_LNCaP_Human1.91701102
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88794626
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84053715
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83616243
19KDM2B_26808549_Chip-Seq_K562_Human1.81901734
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80639300
21SMAD3_21741376_ChIP-Seq_HESCs_Human1.79705105
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.77547951
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.75154013
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72735522
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.72562870
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.67909710
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67751231
28REST_21632747_ChIP-Seq_MESCs_Mouse1.64720768
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64564619
30TBX20_22328084_ChIP-Seq_HEART_Mouse1.64224050
31TBX20_22080862_ChIP-Seq_HEART_Mouse1.64224050
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.63640353
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.63589017
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63201434
35TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61842512
36FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.61276248
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60605972
38AR_19668381_ChIP-Seq_PC3_Human1.59035929
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.58918051
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56473843
41TAL1_26923725_Chip-Seq_HPCs_Mouse1.48592194
42GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48511239
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46876638
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.46304891
45PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.46267607
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.44389176
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43423489
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43423489
49EZH2_22144423_ChIP-Seq_EOC_Human1.41751348
50TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.39297801
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37286574
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36784039
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35756702
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.35612086
55CTCF_27219007_Chip-Seq_Bcells_Human1.32655434
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32339108
57SMC4_20622854_ChIP-Seq_HELA_Human1.32184266
58SMAD4_21799915_ChIP-Seq_A2780_Human1.31576592
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31484828
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.30191179
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29868596
62CLOCK_20551151_ChIP-Seq_293T_Human1.28461298
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28322175
64TBL1_22424771_ChIP-Seq_293T_Human1.27270162
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26087184
66EGR1_19032775_ChIP-ChIP_M12_Human1.25648275
67CREB1_26743006_Chip-Seq_LNCaP_Human1.24527485
68POU5F1_16518401_ChIP-PET_MESCs_Mouse1.24028733
69BCAT_22108803_ChIP-Seq_LS180_Human1.22978762
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.21900573
71* CJUN_26792858_Chip-Seq_BT549_Human1.21441596
72IGF1R_20145208_ChIP-Seq_DFB_Human1.21143952
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20003859
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19836272
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.19541108
76SA1_22415368_ChIP-Seq_MEFs_Mouse1.19488966
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18457405
78STAT3_23295773_ChIP-Seq_U87_Human1.17130160
79ISL1_27105846_Chip-Seq_CPCs_Mouse1.16690734
80SMC1_22415368_ChIP-Seq_MEFs_Mouse1.16441389
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15988981
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15287351
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14250308
84WDR5_24793694_ChIP-Seq_LNCAP_Human1.12099698
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.11924657
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11793593
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11619949
88NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.11159762
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10568209
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.08695888
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08253233
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07210580
93ESR1_21235772_ChIP-Seq_MCF-7_Human1.06656033
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06601763
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05119202
96GATA2_21666600_ChIP-Seq_HMVEC_Human1.05056253
97OCT1_27270436_Chip-Seq_PROSTATE_Human1.04517753
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.03470183
99SMAD4_21741376_ChIP-Seq_HESCs_Human1.03078959
100STAT1_17558387_ChIP-Seq_HELA_Human1.02128193
101TAF2_19829295_ChIP-Seq_ESCs_Human1.02018570
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02014538
103RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01314007
104KDM2B_26808549_Chip-Seq_REH_Human1.00994290
105DPY_21335234_ChIP-Seq_ESCs_Mouse1.00899062
106KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00295344
107KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00295344
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00295344
109RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00106981
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99805929
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99778741
112MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99713425
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99575841
114ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99495595
115JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98922638
116PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96096805
117* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95896409
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95887214
119GATA1_19941827_ChIP-Seq_MEL_Mouse0.95835619
120CBP_21632823_ChIP-Seq_H3396_Human0.95450945
121CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94739309
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94237944
123RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93935608
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93907797
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93691874
126* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93687878
127RNF2_27304074_Chip-Seq_NSC_Mouse0.93373675
128SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93322490
129WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93172832
130SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93047957
131PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92965997
132ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92627825
133OCT4_19829295_ChIP-Seq_ESCs_Human0.92515288
134CSB_26484114_Chip-Seq_FIBROBLAST_Human0.92462058
135ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92209845
136EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92090226
137RING1B_27294783_Chip-Seq_ESCs_Mouse0.92050028
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.91765096
139GF1_26923725_Chip-Seq_HPCs_Mouse0.91052130
140P300_19829295_ChIP-Seq_ESCs_Human0.90595403
141CTCF_20526341_ChIP-Seq_ESCs_Human0.90479729
142SMAD4_21741376_ChIP-Seq_ESCs_Human0.89802605
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89743357
144SA1_27219007_Chip-Seq_Bcells_Human0.89399280
145GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89111277
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88860690
147FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.88191671
148ELK3_25401928_ChIP-Seq_HUVEC_Human0.86713117
149TCF4_23295773_ChIP-Seq_U87_Human0.86691455
150SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85801713
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85651366
152TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85585169
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.85531067
154GF1B_26923725_Chip-Seq_HPCs_Mouse0.85132444
155LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84805678
156* P68_20966046_ChIP-Seq_HELA_Human0.84787904
157AHR_22903824_ChIP-Seq_MCF-7_Human0.84483193
158PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84228705
159TP53_20018659_ChIP-ChIP_R1E_Mouse0.83763274
160TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83655921
161SMAD3_21741376_ChIP-Seq_ESCs_Human0.83569177
162RXR_22158963_ChIP-Seq_LIVER_Mouse0.82261569

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003011_delayed_dark_adaptation8.98230295
2* MP0005253_abnormal_eye_physiology7.36273999
3* MP0006072_abnormal_retinal_apoptosis6.04531405
4MP0003950_abnormal_plasma_membrane4.25983013
5* MP0005195_abnormal_posterior_eye4.23253729
6* MP0005391_vision/eye_phenotype3.54833241
7* MP0001324_abnormal_eye_pigmentation3.46986818
8MP0005423_abnormal_somatic_nervous3.28740297
9MP0002638_abnormal_pupillary_reflex3.04988177
10* MP0002229_neurodegeneration2.88250664
11* MP0002090_abnormal_vision2.43043870
12MP0001986_abnormal_taste_sensitivity2.42285827
13* MP0002752_abnormal_somatic_nervous2.10272185
14* MP0005551_abnormal_eye_electrophysiolog10.6793231
15MP0002653_abnormal_ependyma_morphology1.81014701
16* MP0002882_abnormal_neuron_morphology1.56009818
17* MP0001764_abnormal_homeostasis1.34285867
18MP0004233_abnormal_muscle_weight1.29675737
19MP0004270_analgesia1.23048023
20MP0005275_abnormal_skin_tensile1.20457021
21MP0004885_abnormal_endolymph1.14726337
22MP0001502_abnormal_circadian_rhythm1.14571743
23MP0005197_abnormal_uvea_morphology1.10336145
24MP0005171_absent_coat_pigmentation1.10107086
25MP0005503_abnormal_tendon_morphology1.07786399
26MP0001984_abnormal_olfaction1.07644212
27MP0001486_abnormal_startle_reflex1.02045420
28MP0002332_abnormal_exercise_endurance0.94870693
29MP0003634_abnormal_glial_cell0.91097336
30MP0008438_abnormal_cutaneous_collagen0.90391614
31MP0003880_abnormal_central_pattern0.88743474
32MP0002272_abnormal_nervous_system0.87555568
33MP0005394_taste/olfaction_phenotype0.87247076
34MP0005499_abnormal_olfactory_system0.87247076
35MP0002127_abnormal_cardiovascular_syste0.85325223
36MP0006292_abnormal_olfactory_placode0.82888585
37MP0004859_abnormal_synaptic_plasticity0.79948072
38MP0005187_abnormal_penis_morphology0.79517659
39MP0003136_yellow_coat_color0.77923672
40MP0003724_increased_susceptibility_to0.72351018
41MP0002734_abnormal_mechanical_nocicepti0.69366977
42MP0009046_muscle_twitch0.68464502
43MP0002933_joint_inflammation0.68282578
44MP0002064_seizures0.67946637
45MP0003635_abnormal_synaptic_transmissio0.67710350
46MP0000465_gastrointestinal_hemorrhage0.67226490
47MP0008789_abnormal_olfactory_epithelium0.65604605
48* MP0004019_abnormal_vitamin_homeostasis0.64747922
49MP0001963_abnormal_hearing_physiology0.52818025
50MP0002075_abnormal_coat/hair_pigmentati0.50836797
51MP0002063_abnormal_learning/memory/cond0.50393911
52MP0005167_abnormal_blood-brain_barrier0.50202803
53MP0001968_abnormal_touch/_nociception0.49406906
54MP0002877_abnormal_melanocyte_morpholog0.48322761
55MP0002067_abnormal_sensory_capabilities0.47419029
56MP0002572_abnormal_emotion/affect_behav0.45078557
57MP0005386_behavior/neurological_phenoty0.44709234
58MP0004924_abnormal_behavior0.44709234
59MP0008004_abnormal_stomach_pH0.44542325
60MP0009745_abnormal_behavioral_response0.44501995
61MP0005409_darkened_coat_color0.43718563
62MP0004215_abnormal_myocardial_fiber0.41888544
63MP0005508_abnormal_skeleton_morphology0.41588449
64MP0000372_irregular_coat_pigmentation0.41576734
65MP0002295_abnormal_pulmonary_circulatio0.40525498
66MP0003045_fibrosis0.38823258
67MP0004272_abnormal_basement_membrane0.38404372
68MP0004742_abnormal_vestibular_system0.38379468
69MP0001186_pigmentation_phenotype0.35724470
70MP0004085_abnormal_heartbeat0.35684722
71MP0002249_abnormal_larynx_morphology0.35513178
72MP0009780_abnormal_chondrocyte_physiolo0.35193341
73MP0005623_abnormal_meninges_morphology0.35024471
74MP0008569_lethality_at_weaning0.34686496
75MP0002697_abnormal_eye_size0.34403740
76MP0005620_abnormal_muscle_contractility0.34242613
77MP0003300_gastrointestinal_ulcer0.34164076
78MP0004145_abnormal_muscle_electrophysio0.33527902
79* MP0001286_abnormal_eye_development0.32998551
80MP0005257_abnormal_intraocular_pressure0.31910415
81MP0004043_abnormal_pH_regulation0.30527393
82MP0003878_abnormal_ear_physiology0.29560266
83MP0005377_hearing/vestibular/ear_phenot0.29560266
84* MP0005376_homeostasis/metabolism_phenot0.29339638
85MP0005193_abnormal_anterior_eye0.29117560
86MP0000747_muscle_weakness0.28857220
87MP0005076_abnormal_cell_differentiation0.28604701
88MP0001915_intracranial_hemorrhage0.28444224
89MP0002152_abnormal_brain_morphology0.28405452
90MP0003252_abnormal_bile_duct0.28140224
91MP0002066_abnormal_motor_capabilities/c0.27332766
92MP0004811_abnormal_neuron_physiology0.26956537
93MP0006138_congestive_heart_failure0.26840363
94MP0004142_abnormal_muscle_tone0.26299603
95MP0005248_abnormal_Harderian_gland0.26072311
96MP0002184_abnormal_innervation0.26016632
97MP0002909_abnormal_adrenal_gland0.25928649
98MP0000631_abnormal_neuroendocrine_gland0.25615658
99MP0010386_abnormal_urinary_bladder0.25186236
100MP0001346_abnormal_lacrimal_gland0.25137222
101MP0005595_abnormal_vascular_smooth0.24932283
102MP0000462_abnormal_digestive_system0.24433576
103MP0000516_abnormal_urinary_system0.23975691
104MP0005367_renal/urinary_system_phenotyp0.23975691
105MP0002822_catalepsy0.23405653
106MP0000749_muscle_degeneration0.23172864
107MP0004036_abnormal_muscle_relaxation0.23110029
108MP0000026_abnormal_inner_ear0.23074827
109MP0002102_abnormal_ear_morphology0.22371994
110MP0001958_emphysema0.22181603
111MP0004782_abnormal_surfactant_physiolog0.22055667
112MP0009764_decreased_sensitivity_to0.21892715
113MP0008775_abnormal_heart_ventricle0.21522180
114MP0000778_abnormal_nervous_system0.21358547
115MP0004084_abnormal_cardiac_muscle0.21065854
116MP0003632_abnormal_nervous_system0.21011145
117MP0003633_abnormal_nervous_system0.20932049
118MP0003646_muscle_fatigue0.20839414
119MP0002009_preneoplasia0.20297293
120MP0003890_abnormal_embryonic-extraembry0.20188192
121MP0001905_abnormal_dopamine_level0.20028112
122MP0003943_abnormal_hepatobiliary_system0.19854320
123MP0008961_abnormal_basal_metabolism0.19462499
124MP0002928_abnormal_bile_duct0.19171237
125MP0005390_skeleton_phenotype0.19127662
126MP0003075_altered_response_to0.19118741
127MP0005165_increased_susceptibility_to0.19086100
128MP0000767_abnormal_smooth_muscle0.18677935
129MP0002092_abnormal_eye_morphology0.18573859
130MP0002108_abnormal_muscle_morphology0.18247357
131MP0006054_spinal_hemorrhage0.18187734
132MP0000343_altered_response_to0.17969779
133MP0003631_nervous_system_phenotype0.16609613
134MP0003705_abnormal_hypodermis_morpholog0.16541452
135MP0005023_abnormal_wound_healing0.16397803
136MP0000249_abnormal_blood_vessel0.16137970
137MP0005174_abnormal_tail_pigmentation0.15797300
138MP0005330_cardiomyopathy0.15716103
139MP0000751_myopathy0.15517479
140MP0003638_abnormal_response/metabolism_0.15137992
141MP0001177_atelectasis0.15119529
142MP0000163_abnormal_cartilage_morphology0.14597200
143MP0001970_abnormal_pain_threshold0.14159398
144MP0010368_abnormal_lymphatic_system0.14149732
145MP0002938_white_spotting0.13942339
146MP0003566_abnormal_cell_adhesion0.13902543
147MP0001661_extended_life_span0.13625360
148MP0002557_abnormal_social/conspecific_i0.13129331
149MP0000920_abnormal_myelination0.13036427
150MP0001879_abnormal_lymphatic_vessel0.12815486
151MP0000534_abnormal_ureter_morphology0.12356574
152MP0002128_abnormal_blood_circulation0.12031657
153MP0009250_abnormal_appendicular_skeleto0.11648447
154MP0001851_eye_inflammation0.11273606
155MP0005408_hypopigmentation0.11043720
156MP0002998_abnormal_bone_remodeling0.10697047
157MP0005369_muscle_phenotype0.10600992
158MP0003279_aneurysm0.10595165
159MP0001727_abnormal_embryo_implantation0.09662057
160MP0003828_pulmonary_edema0.09171868
161MP0001533_abnormal_skeleton_physiology0.08415619
162MP0000759_abnormal_skeletal_muscle0.08243702
163MP0002282_abnormal_trachea_morphology0.07969627
164MP0004484_altered_response_of0.07854269
165MP0004087_abnormal_muscle_fiber0.07853711
166MP0003091_abnormal_cell_migration0.07378783

Predicted human phenotypes

RankGene SetZ-score
1Pigmentary retinal degeneration (HP:0001146)9.25769546
2Dyschromatopsia (HP:0007641)9.10432057
3Central scotoma (HP:0000603)8.97581930
4Chorioretinal atrophy (HP:0000533)8.47236076
5Abnormality of macular pigmentation (HP:0008002)8.19415695
6Scotoma (HP:0000575)8.00392922
7Pendular nystagmus (HP:0012043)7.96272934
8Attenuation of retinal blood vessels (HP:0007843)7.73232446
9Abolished electroretinogram (ERG) (HP:0000550)6.87599571
10Decreased central vision (HP:0007663)6.77342480
11* Photophobia (HP:0000613)5.63928956
12* Type II diabetes mellitus (HP:0005978)5.48045918
13Macular degeneration (HP:0000608)5.45679355
14Vitreoretinal degeneration (HP:0000655)5.29243841
15Keratoconus (HP:0000563)5.00468966
16Increased corneal curvature (HP:0100692)5.00468966
17Severe visual impairment (HP:0001141)4.92863155
18Posterior subcapsular cataract (HP:0007787)4.92630190
19Cone-rod dystrophy (HP:0000548)4.78786285
20Choroideremia (HP:0001139)4.76301818
21Constricted visual fields (HP:0001133)4.57574809
22* Retinitis pigmentosa (HP:0000510)4.07532155
23Ulnar claw (HP:0001178)3.49111148
24Progressive visual loss (HP:0000529)3.34453764
25Systemic lupus erythematosus (HP:0002725)3.22061641
26Retinal atrophy (HP:0001105)3.18579977
27Subcapsular cataract (HP:0000523)2.99608181
28Complement deficiency (HP:0004431)2.84007536
29Segmental peripheral demyelination/remyelination (HP:0003481)2.78622686
30Congenital sensorineural hearing impairment (HP:0008527)2.70975280
31Action tremor (HP:0002345)2.67615424
32Termporal pattern (HP:0011008)2.62199252
33Insidious onset (HP:0003587)2.62199252
34Optic disc pallor (HP:0000543)2.61547574
35Peripheral hypomyelination (HP:0007182)2.58021569
36* Wide nasal bridge (HP:0000431)2.43628125
37Hypopigmentation of the fundus (HP:0007894)2.43605797
38Abnormality of complement system (HP:0005339)2.42762399
39Abnormal pupillary function (HP:0007686)2.34596016
40Amyloidosis (HP:0011034)2.12017266
41White forelock (HP:0002211)2.10757151
42Gait imbalance (HP:0002141)2.08106378
43* Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07687772
44Congenital primary aphakia (HP:0007707)2.05803235
45* Congenital stationary night blindness (HP:0007642)13.9401646
46Absent rod-and cone-mediated responses on ERG (HP:0007688)11.1677555
47* Bony spicule pigmentary retinopathy (HP:0007737)10.8407480
48Abnormal rod and cone electroretinograms (HP:0008323)10.4635377
49Hypoplasia of the iris (HP:0007676)1.97472715
50Upper limb muscle weakness (HP:0003484)1.93779200
51Nemaline bodies (HP:0003798)1.93434426
52Glomerulonephritis (HP:0000099)1.90112096
53Patchy hypopigmentation of hair (HP:0011365)1.82803364
54Muscle fiber inclusion bodies (HP:0100299)1.80627315
55Nephrogenic diabetes insipidus (HP:0009806)1.80135471
56Interstitial pulmonary disease (HP:0006530)1.74625820
57Medial flaring of the eyebrow (HP:0010747)1.71358255
58Polar cataract (HP:0010696)1.66356414
59Increased CSF protein (HP:0002922)1.64764772
60Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.64496313
61Horizontal nystagmus (HP:0000666)1.63032209
62Calf muscle hypertrophy (HP:0008981)1.61955573
63Foot dorsiflexor weakness (HP:0009027)1.61542316
64Protrusio acetabuli (HP:0003179)1.59312062
65Poor coordination (HP:0002370)1.57124963
66Aortic aneurysm (HP:0004942)1.55802352
67* Optic atrophy (HP:0000648)1.53742856
68Abnormality of the foot musculature (HP:0001436)1.53411617
69Postural tremor (HP:0002174)1.52621567
70Muscle fiber splitting (HP:0003555)1.51241912
71Progressive sensorineural hearing impairment (HP:0000408)1.50358526
72Impaired proprioception (HP:0010831)1.50207162
73Type 1 muscle fiber predominance (HP:0003803)1.47882246
74Distal arthrogryposis (HP:0005684)1.44920347
75Muscle hypertrophy of the lower extremities (HP:0008968)1.43621751
76Vaginal atresia (HP:0000148)1.41853775
77Pulmonary artery stenosis (HP:0004415)1.37043408
78Severe Myopia (HP:0011003)1.36809867
79True hermaphroditism (HP:0010459)1.36355498
80Nephritis (HP:0000123)1.35823766
81Distal lower limb muscle weakness (HP:0009053)1.35767245
82Genital tract atresia (HP:0001827)1.35703680
83Thyroiditis (HP:0100646)1.33636154
84Increased connective tissue (HP:0009025)1.30493270
85Steppage gait (HP:0003376)1.29495970
86Vertebral compression fractures (HP:0002953)1.28064098
87Dysdiadochokinesis (HP:0002075)1.27405196
88Difficulty running (HP:0009046)1.25850286
89Retinal detachment (HP:0000541)1.25319156
90Distal lower limb amyotrophy (HP:0008944)1.24982961
91Pancreatic fibrosis (HP:0100732)1.24547907
92Abnormality of the fovea (HP:0000493)1.19926794
93Epileptic encephalopathy (HP:0200134)1.19923212
94Aplasia/Hypoplasia of the lens (HP:0008063)1.19385286
95Bulbar palsy (HP:0001283)1.17986956
96Asymmetry of the thorax (HP:0001555)1.15318686
97Aplasia/Hypoplasia of the fovea (HP:0008060)1.14869071
98Hypoplasia of the fovea (HP:0007750)1.14869071
99Heterochromia iridis (HP:0001100)1.14668209
100Stereotypic behavior (HP:0000733)1.13813563
101Blue irides (HP:0000635)1.09721973
102Visual hallucinations (HP:0002367)1.09456330
103Absent phalangeal crease (HP:0006109)1.07135778
104Cystic liver disease (HP:0006706)1.05677602
105Febrile seizures (HP:0002373)1.05032587
106Recurrent sinusitis (HP:0011108)1.02267764
107Neck muscle weakness (HP:0000467)1.00452883
108Astigmatism (HP:0000483)1.00190547
109Truncal ataxia (HP:0002078)0.98990337
110Bilateral sensorineural hearing impairment (HP:0008619)0.98532966
111Pancreatic cysts (HP:0001737)0.97295215
112Peripheral demyelination (HP:0011096)0.96289118
113Round ear (HP:0100830)0.95698319
114Progressive cerebellar ataxia (HP:0002073)0.93595733
115Bicornuate uterus (HP:0000813)0.93257699
116Onion bulb formation (HP:0003383)0.93181204
117Hammertoe (HP:0001765)0.93061596
118Aplasia/Hypoplasia of the macula (HP:0008059)0.90760572
119Ulnar deviation of the wrist (HP:0003049)0.90612449
120Lower limb amyotrophy (HP:0007210)0.90561540
121Chorioretinal coloboma (HP:0000567)0.89494490
122Albinism (HP:0001022)0.89305732
123Spontaneous hematomas (HP:0007420)0.89305313
124Hemorrhage of the eye (HP:0011885)0.88712235
125Hypermetropia (HP:0000540)0.87764491
126Annular pancreas (HP:0001734)0.87730226
127Aplasia/Hypoplasia of the tongue (HP:0010295)0.86778858
128Left ventricular hypertrophy (HP:0001712)0.85637922
129Aplasia/Hypoplasia affecting the retina (HP:0008061)0.84831541
130Specific learning disability (HP:0001328)0.84575683
131Broad foot (HP:0001769)0.83546699
132Prolonged QT interval (HP:0001657)0.83246864
133Sclerocornea (HP:0000647)0.81325160
134Genetic anticipation (HP:0003743)0.79692861
135Furrowed tongue (HP:0000221)0.77987309
136Decreased testicular size (HP:0008734)0.76585218
137Asthma (HP:0002099)0.76465843
138Macroorchidism (HP:0000053)0.73301511
139Cerebellar dysplasia (HP:0007033)0.71711516
140Corneal dystrophy (HP:0001131)0.71002434
141Lymphopenia (HP:0001888)0.67869940
142Broad-based gait (HP:0002136)0.66606079
143Abnormal EKG (HP:0003115)0.65162559
144Abnormality of the fingertips (HP:0001211)0.64932213
145Aqueductal stenosis (HP:0002410)0.64897325
146Abnormality of midbrain morphology (HP:0002418)0.63802507
147Molar tooth sign on MRI (HP:0002419)0.63802507
148Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.63153341
149Anencephaly (HP:0002323)0.62877961
150Abnormality of dental color (HP:0011073)0.62689660
151Zonular cataract (HP:0010920)0.62626352
152Syncope (HP:0001279)0.61303869
153Abnormality of cells of the lymphoid lineage (HP:0012140)0.61176836
154Generalized myoclonic seizures (HP:0002123)0.59270046
155Supranuclear gaze palsy (HP:0000605)0.58948184
156Hypoventilation (HP:0002791)0.58871384
157Depression (HP:0000716)0.58089421
158Dysmetric saccades (HP:0000641)0.57455668
159Postaxial hand polydactyly (HP:0001162)0.57007484
160Partial agenesis of the corpus callosum (HP:0001338)0.56934824
161Dental crowding (HP:0000678)0.56600395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN7.80437363
2PBK6.86018776
3* GRK16.46547703
4OBSCN4.69310712
5ERN14.03882606
6TGFBR23.91413942
7EPHA33.83521807
8PINK13.75645048
9IRAK22.71357449
10TRPM72.50456954
11SIK22.44839556
12MAP3K102.40401403
13EPHB12.37490635
14CAMK1G2.25927738
15CDK122.05568408
16ADRBK11.97376252
17CSK1.87284447
18CAMK1D1.85575884
19TIE11.81030358
20HIPK21.79078074
21PAK61.77716096
22MAPK71.75205157
23STK391.74314367
24DDR21.71877401
25BRD41.69738767
26PNCK1.67612257
27TAOK31.67494109
28STK381.67269571
29MAPK121.65562811
30INSRR1.62455365
31MAP3K41.59823682
32MARK11.52537783
33PTK2B1.49397467
34ICK1.48397017
35TGFBR11.46691019
36EPHB21.46174029
37PRKD31.40835995
38PRKCH1.38567982
39ERBB21.32808583
40NEK11.32421285
41RPS6KA41.32001366
42SGK4941.31659301
43SGK2231.31659301
44MAPKAPK31.30722440
45PIK3CG1.28069869
46MARK31.25131937
47PRKCZ1.22764983
48CAMKK11.21027408
49WNK11.19253853
50GRK51.14112168
51SGK21.12170975
52STK241.10933568
53SGK31.07173266
54NLK1.06687030
55JAK11.04006498
56FER1.03839779
57BTK0.99531656
58PLK20.95074445
59LRRK20.94941461
60TTK0.92410711
61PRKAA10.91440647
62ABL20.87994515
63FES0.86662150
64SMG10.84785747
65CAMK2D0.84641193
66DYRK1A0.84330391
67MAP3K30.84206934
68GSK3A0.83715185
69NEK20.83056437
70PRKACG0.82693856
71AKT30.82613770
72MYLK0.81398880
73LATS10.80089333
74RPS6KA30.79894878
75PRKAA20.78384828
76TYK20.78139985
77CCNB10.75593513
78SCYL20.75507488
79* PRKCB0.74714741
80DYRK1B0.72392602
81PHKG20.71894105
82PHKG10.71894105
83CDK50.70799437
84PRKD20.70001674
85IRAK10.69791607
86JAK20.67515446
87CAMK10.67096275
88SGK10.66184241
89CDK30.63507325
90MINK10.61518218
91MAP3K70.61152800
92GSK3B0.60563017
93MAPK30.60257484
94MAPK40.60105468
95SIK10.60044911
96STK30.59231438
97STK110.57689050
98AKT20.57679013
99MAP2K40.57598899
100MAP2K70.57336077
101CAMK40.56624504
102CDK90.56554699
103* CSNK1D0.56319249
104MAPK100.56063810
105PAK20.55445166
106MAPK140.54791287
107PLK30.54287075
108PRKG10.53502724
109NTRK30.53357366
110MAPK90.53025830
111ALK0.52315030
112PRKCG0.47962829
113FRK0.47355664
114CAMK2A0.46622669
115PKN10.46496012
116CDK10.45872420
117FGFR40.43449658
118PDGFRA0.42734055
119PRKCD0.42013343
120PRKACA0.41987118
121PDPK10.39735832
122UHMK10.38661346
123WNK40.37677512
124CDC42BPA0.37408501
125CSNK1E0.36450469
126RPS6KB10.36052617
127PTK20.35324122
128HCK0.35196167
129NEK60.33803377
130MAPK80.33118676
131PKN20.33071775
132CHEK20.32703698
133ARAF0.32520508
134ZAP700.30647405
135MAP3K90.30372662
136* PRKDC0.30366796
137MET0.29526996
138BMX0.29047489
139RET0.28922463
140ROCK10.28741822
141KSR20.28716886
142PRKD10.28520303
143SRC0.27924585
144BRAF0.27906343
145RIPK10.27029473
146TEC0.26638457
147* PRKCA0.26514028
148FYN0.26220792
149ATM0.26177514
150MAP3K10.25649152
151NTRK20.25310339
152CDK150.24936749
153PDK10.24820232
154FGFR30.24173943
155MAPK10.23841198
156SYK0.23188285
157DMPK0.23106857
158MAPKAPK20.22018523
159PDGFRB0.21832093
160PIK3CA0.21159358
161MOS0.20341806

Predicted pathways (KEGG)

RankGene SetZ-score
1* Phototransduction_Homo sapiens_hsa0474415.8195469
2Synaptic vesicle cycle_Homo sapiens_hsa047211.64459412
3Olfactory transduction_Homo sapiens_hsa047401.47073844
4Complement and coagulation cascades_Homo sapiens_hsa046101.37164079
5Nitrogen metabolism_Homo sapiens_hsa009101.26463353
6GABAergic synapse_Homo sapiens_hsa047271.22861014
7Staphylococcus aureus infection_Homo sapiens_hsa051501.15591740
8Cholinergic synapse_Homo sapiens_hsa047250.91763376
9Retinol metabolism_Homo sapiens_hsa008300.88961427
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86124877
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84004670
12Glutamatergic synapse_Homo sapiens_hsa047240.83932462
13Circadian entrainment_Homo sapiens_hsa047130.81807065
14Morphine addiction_Homo sapiens_hsa050320.80105028
15Ether lipid metabolism_Homo sapiens_hsa005650.78972183
16Dopaminergic synapse_Homo sapiens_hsa047280.78149128
17Arachidonic acid metabolism_Homo sapiens_hsa005900.75991730
18Circadian rhythm_Homo sapiens_hsa047100.75138738
19Malaria_Homo sapiens_hsa051440.73171352
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72235456
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70833847
22ABC transporters_Homo sapiens_hsa020100.68607083
23Linoleic acid metabolism_Homo sapiens_hsa005910.65775071
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62423888
25Serotonergic synapse_Homo sapiens_hsa047260.60930360
26Insulin secretion_Homo sapiens_hsa049110.60107654
27cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56096680
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53647771
29Nicotine addiction_Homo sapiens_hsa050330.51931412
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51884126
31Caffeine metabolism_Homo sapiens_hsa002320.49219976
32Pertussis_Homo sapiens_hsa051330.48904792
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47536295
34Oxytocin signaling pathway_Homo sapiens_hsa049210.47322279
35Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43527705
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43285941
37Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41680954
38Arginine biosynthesis_Homo sapiens_hsa002200.41083037
39TGF-beta signaling pathway_Homo sapiens_hsa043500.41042506
40Purine metabolism_Homo sapiens_hsa002300.39314204
41Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39060299
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38182474
43cAMP signaling pathway_Homo sapiens_hsa040240.37850436
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37733733
45Renin secretion_Homo sapiens_hsa049240.37093951
46Dilated cardiomyopathy_Homo sapiens_hsa054140.36842350
47Prion diseases_Homo sapiens_hsa050200.36708636
48Salivary secretion_Homo sapiens_hsa049700.36692841
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35335351
50Adherens junction_Homo sapiens_hsa045200.34991669
51Gastric acid secretion_Homo sapiens_hsa049710.34881566
52Fructose and mannose metabolism_Homo sapiens_hsa000510.34115865
53Inositol phosphate metabolism_Homo sapiens_hsa005620.34110566
54Cardiac muscle contraction_Homo sapiens_hsa042600.33701795
55ECM-receptor interaction_Homo sapiens_hsa045120.33307285
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32604644
57Glycerolipid metabolism_Homo sapiens_hsa005610.32281777
58Phenylalanine metabolism_Homo sapiens_hsa003600.31781322
59mTOR signaling pathway_Homo sapiens_hsa041500.31530993
60Cocaine addiction_Homo sapiens_hsa050300.31104818
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30893198
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.30172311
63Long-term potentiation_Homo sapiens_hsa047200.30105434
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29956821
65Melanoma_Homo sapiens_hsa052180.28099469
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27999359
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27822358
68Tyrosine metabolism_Homo sapiens_hsa003500.27161106
69Glutathione metabolism_Homo sapiens_hsa004800.27047135
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.26818661
71Lysine degradation_Homo sapiens_hsa003100.26301474
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25654873
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25052712
74Type II diabetes mellitus_Homo sapiens_hsa049300.24493883
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.24297750
76FoxO signaling pathway_Homo sapiens_hsa040680.23905635
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.23412964
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22900869
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22702207
80Bile secretion_Homo sapiens_hsa049760.21902159
81Glucagon signaling pathway_Homo sapiens_hsa049220.21686201
82PPAR signaling pathway_Homo sapiens_hsa033200.21460263
83Amphetamine addiction_Homo sapiens_hsa050310.21319758
84Focal adhesion_Homo sapiens_hsa045100.21149780
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20826618
86Fatty acid elongation_Homo sapiens_hsa000620.19867657
87Vibrio cholerae infection_Homo sapiens_hsa051100.19432044
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18606959
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18438119
90Chemokine signaling pathway_Homo sapiens_hsa040620.18272960
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.17734682
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17193992
93GnRH signaling pathway_Homo sapiens_hsa049120.16816169
94Calcium signaling pathway_Homo sapiens_hsa040200.16596350
95HIF-1 signaling pathway_Homo sapiens_hsa040660.16171688
96AMPK signaling pathway_Homo sapiens_hsa041520.16168894
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16110852
98Phagosome_Homo sapiens_hsa041450.16085596
99Proteoglycans in cancer_Homo sapiens_hsa052050.15754382
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15585945
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15334679
102Alcoholism_Homo sapiens_hsa050340.15281648
103Biosynthesis of amino acids_Homo sapiens_hsa012300.15214910
104Pancreatic secretion_Homo sapiens_hsa049720.14826348
105Non-small cell lung cancer_Homo sapiens_hsa052230.14370892
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14145751
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.14098351
108Tryptophan metabolism_Homo sapiens_hsa003800.13749105
109Amoebiasis_Homo sapiens_hsa051460.13638993
110Thyroid hormone synthesis_Homo sapiens_hsa049180.12993402
111Rheumatoid arthritis_Homo sapiens_hsa053230.11963410
112Ras signaling pathway_Homo sapiens_hsa040140.11619531
113Tight junction_Homo sapiens_hsa045300.11437617
114Galactose metabolism_Homo sapiens_hsa000520.10990894
115MAPK signaling pathway_Homo sapiens_hsa040100.10755611
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.10563926
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.10382587
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.10375308
119Osteoclast differentiation_Homo sapiens_hsa043800.09649948
120African trypanosomiasis_Homo sapiens_hsa051430.09600632
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.09263257
122Insulin resistance_Homo sapiens_hsa049310.09238448
123Glioma_Homo sapiens_hsa052140.09178264
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08869471
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.08747650
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.08733492
127Tuberculosis_Homo sapiens_hsa051520.08435908
128Renal cell carcinoma_Homo sapiens_hsa052110.08046964
129Lysosome_Homo sapiens_hsa041420.07041656
130Mineral absorption_Homo sapiens_hsa049780.06980080
131Dorso-ventral axis formation_Homo sapiens_hsa043200.06917380
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06884485
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.06585798
134Maturity onset diabetes of the young_Homo sapiens_hsa049500.06514055
135Prostate cancer_Homo sapiens_hsa052150.06308160
136Choline metabolism in cancer_Homo sapiens_hsa052310.06098082
137mRNA surveillance pathway_Homo sapiens_hsa030150.05957602
138Pathways in cancer_Homo sapiens_hsa052000.05539495
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05375586
140Collecting duct acid secretion_Homo sapiens_hsa049660.04997673
141Fatty acid biosynthesis_Homo sapiens_hsa000610.04304464
142Melanogenesis_Homo sapiens_hsa049160.03824268
143Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03609728
144Hippo signaling pathway_Homo sapiens_hsa043900.03510315
145Endocytosis_Homo sapiens_hsa041440.03426001
146Wnt signaling pathway_Homo sapiens_hsa043100.03065863
147Fat digestion and absorption_Homo sapiens_hsa049750.02871380
148Taste transduction_Homo sapiens_hsa047420.02759652
149ErbB signaling pathway_Homo sapiens_hsa040120.02437754
150Gap junction_Homo sapiens_hsa045400.02250931

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