RHOA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.00058545
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.00058545
3Golgi transport vesicle coating (GO:0048200)3.77881288
4COPI coating of Golgi vesicle (GO:0048205)3.77881288
5antigen processing and presentation of endogenous antigen (GO:0019883)3.76739254
6Arp2/3 complex-mediated actin nucleation (GO:0034314)3.63657727
7protein maturation by protein folding (GO:0022417)3.30846556
8neutrophil activation involved in immune response (GO:0002283)3.25248112
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22564372
10detection of other organism (GO:0098543)2.98420580
11fibril organization (GO:0097435)2.80418272
12negative regulation of cell killing (GO:0031342)2.78020209
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.78020209
14phagocytosis, engulfment (GO:0006911)2.77991959
15extracellular fibril organization (GO:0043206)2.72941892
16detection of bacterium (GO:0016045)2.72210907
17regulation of early endosome to late endosome transport (GO:2000641)2.71614438
18response to laminar fluid shear stress (GO:0034616)2.68485482
19peptide catabolic process (GO:0043171)2.67986364
20hypotonic response (GO:0006971)2.66227763
21regulation of protein heterodimerization activity (GO:0043497)2.65649309
22positive regulation of lamellipodium assembly (GO:0010592)2.65245537
23leukocyte aggregation (GO:0070486)2.63506659
24sequestering of metal ion (GO:0051238)2.62719325
25membrane raft organization (GO:0031579)2.61528777
26regulation of superoxide anion generation (GO:0032928)2.61126119
27cell adhesion mediated by integrin (GO:0033627)2.56266741
28actin nucleation (GO:0045010)2.56111099
29morphogenesis of an endothelium (GO:0003159)2.54123619
30endothelial tube morphogenesis (GO:0061154)2.54123619
31pinocytosis (GO:0006907)2.53423777
32response to host (GO:0075136)2.53421797
33response to host defenses (GO:0052200)2.53421797
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.53421797
35negative regulation of protein localization to plasma membrane (GO:1903077)2.52455740
36regulation of mast cell degranulation (GO:0043304)2.51660847
37regulation of leukocyte degranulation (GO:0043300)2.51469917
38immunoglobulin mediated immune response (GO:0016064)2.50966434
39apoptotic cell clearance (GO:0043277)2.50725268
40positive regulation of receptor recycling (GO:0001921)2.50529981
41cellular response to thyroid hormone stimulus (GO:0097067)2.50076212
42regulation of macrophage cytokine production (GO:0010935)2.49974909
43detection of external biotic stimulus (GO:0098581)2.49949211
44response to host immune response (GO:0052572)2.49791360
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.49791360
46* stress fiber assembly (GO:0043149)2.47221479
47positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.47088731
48detection of molecule of bacterial origin (GO:0032490)2.46168060
49positive regulation of leukocyte degranulation (GO:0043302)2.45903005
50regulation of interferon-beta biosynthetic process (GO:0045357)2.42597750
51macrophage activation involved in immune response (GO:0002281)2.42545205
52lipopolysaccharide-mediated signaling pathway (GO:0031663)2.41664108
53myeloid cell homeostasis (GO:0002262)2.40502917
54hyaluronan catabolic process (GO:0030214)2.38660691
55wound healing, spreading of epidermal cells (GO:0035313)2.37521836
56positive regulation of gamma-delta T cell activation (GO:0046645)2.36157972
57establishment of endothelial barrier (GO:0061028)2.36143834
58maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.35757997
59positive regulation by symbiont of host defense response (GO:0052509)2.35039050
60modulation by symbiont of host defense response (GO:0052031)2.35039050
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.35039050
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.35039050
63positive regulation by organism of defense response of other organism involved in symbiotic interact2.35039050
64modulation by symbiont of host immune response (GO:0052553)2.35039050
65basement membrane organization (GO:0071711)2.34590294
66positive regulation of macrophage differentiation (GO:0045651)2.34468107
67detection of biotic stimulus (GO:0009595)2.34101571
68wound healing, spreading of cells (GO:0044319)2.31639861
69glycosphingolipid catabolic process (GO:0046479)2.30917442
70negative regulation of phagocytosis (GO:0050765)2.30093597
71positive regulation of interferon-alpha production (GO:0032727)2.28716029
72establishment of integrated proviral latency (GO:0075713)2.28312523
73neutrophil activation (GO:0042119)2.27852973
74membrane invagination (GO:0010324)2.27777377
75hepatocyte apoptotic process (GO:0097284)2.27647297
76low-density lipoprotein particle clearance (GO:0034383)2.27128382
77pentose-phosphate shunt (GO:0006098)2.26601319
78response to thyroid hormone (GO:0097066)2.26408543
79T cell apoptotic process (GO:0070231)2.26225788
80positive regulation of macrophage cytokine production (GO:0060907)2.26020214
81antigen processing and presentation via MHC class Ib (GO:0002475)2.25023454
82B cell mediated immunity (GO:0019724)2.24840073
83antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.23993357
84regulation of myeloid leukocyte mediated immunity (GO:0002886)2.23664396
85signal peptide processing (GO:0006465)2.23642792
86regulation of SMAD protein import into nucleus (GO:0060390)2.23313237
87endodermal cell differentiation (GO:0035987)2.23092136
88regulation of mast cell activation involved in immune response (GO:0033006)2.22858395
89leukocyte cell-cell adhesion (GO:0007159)2.22439951
90establishment of viral latency (GO:0019043)2.22101891
91NIK/NF-kappaB signaling (GO:0038061)2.20981947
92positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.19153602
93positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.19110789
94regulation of interferon-alpha production (GO:0032647)2.19092077
95lymphocyte apoptotic process (GO:0070227)2.18945036
96myeloid cell activation involved in immune response (GO:0002275)2.18275890
97regulation of defense response to virus by virus (GO:0050690)2.18255154
98JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.18121686
99regulation of integrin-mediated signaling pathway (GO:2001044)2.17624906
100protein retention in ER lumen (GO:0006621)2.17428869
101keratan sulfate catabolic process (GO:0042340)2.17423566
102positive regulation of mast cell activation (GO:0033005)2.16487489
103regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.16146343
104negative regulation of interleukin-17 production (GO:0032700)2.15661719
105skin morphogenesis (GO:0043589)2.15022756
106positive regulation of lamellipodium organization (GO:1902745)2.14874030
107positive regulation of Cdc42 GTPase activity (GO:0043089)2.14746364
108granulocyte activation (GO:0036230)2.14331148
109protein localization to endosome (GO:0036010)2.14213762
110vascular endothelial growth factor signaling pathway (GO:0038084)2.14020153
111positive regulation of B cell differentiation (GO:0045579)2.13750048
112regulation of monocyte chemotaxis (GO:0090025)2.12749132
113regulation of dendritic cell antigen processing and presentation (GO:0002604)2.12405489
114NADPH regeneration (GO:0006740)2.11584871
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.10899772
116regulation of tolerance induction (GO:0002643)2.10899056
117negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.09589114
118respiratory burst (GO:0045730)2.09225794
119angiogenesis involved in wound healing (GO:0060055)2.07406642
120integrin-mediated signaling pathway (GO:0007229)2.07025388
121renal filtration (GO:0097205)2.06454362
122response to peptidoglycan (GO:0032494)2.05792224
123regulation of B cell receptor signaling pathway (GO:0050855)2.05403966
124platelet aggregation (GO:0070527)2.04193190
125production of molecular mediator involved in inflammatory response (GO:0002532)2.03788259
126regulation of metalloenzyme activity (GO:0048552)2.03298633
127regulation of interleukin-12 biosynthetic process (GO:0045075)2.02936053
128positive regulation of SMAD protein import into nucleus (GO:0060391)2.02470280
129cortical actin cytoskeleton organization (GO:0030866)2.02034622
130glomerular filtration (GO:0003094)1.98127313
131localization within membrane (GO:0051668)1.97452768
132positive regulation of nuclease activity (GO:0032075)1.97444339
133regulation of type I interferon-mediated signaling pathway (GO:0060338)1.96079187
134regulation of antigen processing and presentation of peptide antigen (GO:0002583)1.95872551
135response to muramyl dipeptide (GO:0032495)1.94855407
136cellular response to zinc ion (GO:0071294)1.94547881
137growth hormone receptor signaling pathway (GO:0060396)1.93698483
138apoptotic process involved in morphogenesis (GO:0060561)1.92758106
139regulation of gamma-delta T cell differentiation (GO:0045586)1.92573020
140negative regulation of interleukin-12 production (GO:0032695)1.92474406
141regulation of B cell differentiation (GO:0045577)1.92362570
142activation of signaling protein activity involved in unfolded protein response (GO:0006987)1.92269527
143leukocyte apoptotic process (GO:0071887)1.91407735
144regulation of syncytium formation by plasma membrane fusion (GO:0060142)1.91165230
145cellular response to interferon-alpha (GO:0035457)1.90325827
146cellular extravasation (GO:0045123)1.89610332
147barbed-end actin filament capping (GO:0051016)1.89411415
148mesodermal cell differentiation (GO:0048333)1.89222258
149substrate adhesion-dependent cell spreading (GO:0034446)1.89074482
150negative regulation of interleukin-8 production (GO:0032717)1.88761701
151regulation of nuclease activity (GO:0032069)1.87858737
152COPII vesicle coating (GO:0048208)1.87339430
153negative regulation of erythrocyte differentiation (GO:0045647)1.87334662
154positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)1.86817310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.05881112
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.43562261
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.07406728
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.80491604
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76511220
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.68732487
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.50462921
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.30714971
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.26977939
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21792698
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16388060
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.15375314
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14669680
14MYC_22102868_ChIP-Seq_BL_Human2.13024185
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.04320268
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02646927
17CLOCK_20551151_ChIP-Seq_293T_Human1.98754446
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97809523
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.97014301
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91924221
21VDR_21846776_ChIP-Seq_THP-1_Human1.90017336
22IRF8_27001747_Chip-Seq_BMDM_Mouse1.84337510
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83693566
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82520585
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81063979
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78991844
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.75901131
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70479044
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68387462
30MAF_26560356_Chip-Seq_TH1_Human1.67318811
31MYB_26560356_Chip-Seq_TH2_Human1.66779108
32SPI1_23547873_ChIP-Seq_NB4_Human1.66245219
33VDR_24763502_ChIP-Seq_THP-1_Human1.59588648
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55778875
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55689687
36* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51361968
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.50536835
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.47906194
39AR_21909140_ChIP-Seq_LNCAP_Human1.47757210
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46198299
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42359965
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41153956
43MYB_26560356_Chip-Seq_TH1_Human1.40773054
44TFEB_21752829_ChIP-Seq_HELA_Human1.40684569
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39927788
46* RUNX1_22412390_ChIP-Seq_EML_Mouse1.39325852
47UTX_26944678_Chip-Seq_JUKART_Human1.38248266
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37842024
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36276659
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36127523
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34906293
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.34519060
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32459512
54SCL_19346495_ChIP-Seq_HPC-7_Human1.32012519
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31598176
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30764213
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28172155
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27847440
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25220477
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24099495
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.23634591
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22345559
63* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21809950
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21071119
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20988446
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19114751
67RUNX_20019798_ChIP-Seq_JUKART_Human1.18403778
68GATA1_22025678_ChIP-Seq_K562_Human1.18355205
69ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18292203
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18091014
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16648384
72TCF7_22412390_ChIP-Seq_EML_Mouse1.16629749
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13301940
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12014383
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12014383
76FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11634754
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11374246
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11312221
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11158890
80SPI1_23127762_ChIP-Seq_K562_Human1.10391940
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10050099
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09585960
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09017687
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08989303
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07933112
86ELK1_19687146_ChIP-ChIP_HELA_Human1.07577716
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07416961
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05572626
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05158166
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03764128
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03662015
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.03426393
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03210689
94* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02373265
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01580946
96ATF3_27146783_Chip-Seq_COLON_Human1.01495745
97PU_27001747_Chip-Seq_BMDM_Mouse1.01202423
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00613467
99KDM2B_26808549_Chip-Seq_DND41_Human1.00273811
100* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99984803
101E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99983921
102NCOR1_26117541_ChIP-Seq_K562_Human0.99758775
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99287135
104* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99102497
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99077175
106RACK7_27058665_Chip-Seq_MCF-7_Human0.98777677
107XRN2_22483619_ChIP-Seq_HELA_Human0.98472762
108MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98410959
109CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98379476
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97528582
111MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97507611
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.97207241
113CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97125372
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97015248
115* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96987899
116FOXO3_23340844_ChIP-Seq_DLD1_Human0.96967845
117* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96249474
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95339460
119* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94976972
120* GATA3_27048872_Chip-Seq_THYMUS_Human0.94636245
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94600277
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93700916

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.20703490
2MP0006054_spinal_hemorrhage2.49620141
3MP0003705_abnormal_hypodermis_morpholog2.23402314
4MP0003566_abnormal_cell_adhesion2.13279152
5MP0001835_abnormal_antigen_presentation2.12320094
6MP0010352_gastrointestinal_tract_polyps2.07018912
7MP0003300_gastrointestinal_ulcer2.03494738
8MP0008260_abnormal_autophagy2.03071813
9MP0003436_decreased_susceptibility_to1.97222762
10MP0003303_peritoneal_inflammation1.85698391
11MP0005058_abnormal_lysosome_morphology1.84880436
12MP0005275_abnormal_skin_tensile1.84586630
13MP0003279_aneurysm1.82675629
14MP0000685_abnormal_immune_system1.79428548
15MP0001958_emphysema1.67847688
16MP0005023_abnormal_wound_healing1.61188524
17MP0003724_increased_susceptibility_to1.57468849
18MP0005000_abnormal_immune_tolerance1.56769742
19MP0002877_abnormal_melanocyte_morpholog1.53586328
20MP0004272_abnormal_basement_membrane1.52134396
21MP0002419_abnormal_innate_immunity1.52047805
22MP0005387_immune_system_phenotype1.51737354
23MP0001790_abnormal_immune_system1.51737354
24MP0002166_altered_tumor_susceptibility1.49520480
25MP0001533_abnormal_skeleton_physiology1.49447769
26MP0002933_joint_inflammation1.47041985
27MP0009333_abnormal_splenocyte_physiolog1.46783503
28MP0009278_abnormal_bone_marrow1.46772708
29MP0002452_abnormal_antigen_presenting1.46709915
30MP0009785_altered_susceptibility_to1.46337932
31MP0002396_abnormal_hematopoietic_system1.43736850
32MP0003075_altered_response_to1.43144763
33MP0003448_altered_tumor_morphology1.40811903
34MP0005025_abnormal_response_to1.38754863
35MP0004947_skin_inflammation1.37805569
36MP0002148_abnormal_hypersensitivity_rea1.36804890
37MP0000858_altered_metastatic_potential1.35814346
38MP0002405_respiratory_system_inflammati1.35640350
39MP0005076_abnormal_cell_differentiation1.34665358
40MP0001800_abnormal_humoral_immune1.34258339
41MP0005671_abnormal_response_to1.32407681
42MP0002420_abnormal_adaptive_immunity1.31965705
43MP0001819_abnormal_immune_cell1.30919736
44MP0000465_gastrointestinal_hemorrhage1.30692139
45MP0003806_abnormal_nucleotide_metabolis1.30554513
46MP0003172_abnormal_lysosome_physiology1.28874345
47MP0000343_altered_response_to1.27538142
48MP0002723_abnormal_immune_serum1.26571363
49MP0001879_abnormal_lymphatic_vessel1.25790617
50MP0010234_abnormal_vibrissa_follicle1.22602275
51MP0005397_hematopoietic_system_phenotyp1.22132048
52MP0001545_abnormal_hematopoietic_system1.22132048
53MP0006082_CNS_inflammation1.21501665
54MP0005165_increased_susceptibility_to1.21178201
55MP0005257_abnormal_intraocular_pressure1.20555742
56MP0008004_abnormal_stomach_pH1.20346023
57MP0005451_abnormal_body_composition1.20335523
58MP0005464_abnormal_platelet_physiology1.19270150
59MP0004808_abnormal_hematopoietic_stem1.19142620
60MP0005503_abnormal_tendon_morphology1.18317121
61MP0002006_tumorigenesis1.16198217
62MP0010155_abnormal_intestine_physiology1.14730312
63MP0002398_abnormal_bone_marrow1.13062462
64MP0001853_heart_inflammation1.12452176
65MP0003091_abnormal_cell_migration1.12402069
66MP0010368_abnormal_lymphatic_system1.11887834
67MP0010307_abnormal_tumor_latency1.10364325
68MP0000490_abnormal_crypts_of1.08829813
69MP0008007_abnormal_cellular_replicative1.08613645
70MP0005164_abnormal_response_to1.08424253
71MP0000716_abnormal_immune_system1.07754276
72MP0003763_abnormal_thymus_physiology1.07079852
73MP0001845_abnormal_inflammatory_respons1.06591464
74MP0003828_pulmonary_edema1.06103075
75MP0003191_abnormal_cellular_cholesterol1.04429845
76MP0000689_abnormal_spleen_morphology1.01567946
77MP0002722_abnormal_immune_system1.01167862
78MP0009384_cardiac_valve_regurgitation1.00674332
79MP0005390_skeleton_phenotype1.00169713
80MP0002060_abnormal_skin_morphology0.99796450
81MP0000733_abnormal_muscle_development0.99173470
82MP0002429_abnormal_blood_cell0.98999930
83MP0004883_abnormal_blood_vessel0.98790508
84MP0003453_abnormal_keratinocyte_physiol0.98746100
85MP0009840_abnormal_foam_cell0.98538867
86MP0001243_abnormal_dermal_layer0.97982430
87MP0000767_abnormal_smooth_muscle0.97480668
88MP0004957_abnormal_blastocyst_morpholog0.95244556
89MP0002998_abnormal_bone_remodeling0.94453531
90MP0003186_abnormal_redox_activity0.92570218
91MP0005621_abnormal_cell_physiology0.92111325
92MP0005166_decreased_susceptibility_to0.91956273
93MP0003183_abnormal_peptide_metabolism0.88541649
94MP0003693_abnormal_embryo_hatching0.88191261
95MP0000015_abnormal_ear_pigmentation0.87924677
96MP0003795_abnormal_bone_structure0.86812470
97MP0002132_abnormal_respiratory_system0.83754404
98MP0009763_increased_sensitivity_to0.83658850
99MP0001851_eye_inflammation0.83237753
100MP0001915_intracranial_hemorrhage0.83063718
101MP0003077_abnormal_cell_cycle0.81978717
102MP0001873_stomach_inflammation0.81906498
103MP0004185_abnormal_adipocyte_glucose0.81718822
104MP0002138_abnormal_hepatobiliary_system0.80185662
105MP0004510_myositis0.79050687
106MP0005623_abnormal_meninges_morphology0.78735903
107MP0009053_abnormal_anal_canal0.78341199
108MP0000249_abnormal_blood_vessel0.75322553
109MP0008469_abnormal_protein_level0.75281709
110MP0002019_abnormal_tumor_incidence0.74593948
111MP0001730_embryonic_growth_arrest0.74258635
112MP0001542_abnormal_bone_strength0.74251393
113MP0000383_abnormal_hair_follicle0.73947122
114MP0003950_abnormal_plasma_membrane0.73761486
115MP0000703_abnormal_thymus_morphology0.72695305
116MP0000350_abnormal_cell_proliferation0.71261666
117MP0003567_abnormal_fetal_cardiomyocyte0.70844048
118MP0001849_ear_inflammation0.70664246
119MP0005508_abnormal_skeleton_morphology0.70218924

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.57408862
2Eczematoid dermatitis (HP:0000976)3.53259354
3Premature rupture of membranes (HP:0001788)3.50535458
4Recurrent abscess formation (HP:0002722)3.37132961
5Osteolytic defects of the phalanges of the hand (HP:0009771)3.15645926
6Osteolytic defects of the hand bones (HP:0009699)3.15645926
7Cervical subluxation (HP:0003308)2.93540194
8Ankle contracture (HP:0006466)2.85486163
9Loss of speech (HP:0002371)2.83176944
10Cerebral aneurysm (HP:0004944)2.81033909
11Aortic dissection (HP:0002647)2.80028632
12Interstitial pulmonary disease (HP:0006530)2.80005214
13Vacuolated lymphocytes (HP:0001922)2.76551547
14Recurrent bacterial skin infections (HP:0005406)2.76220301
15Aortic aneurysm (HP:0004942)2.69075660
16Hepatosplenomegaly (HP:0001433)2.69050018
17Hematochezia (HP:0002573)2.68810793
18Prolonged bleeding time (HP:0003010)2.65318741
19Abnormality of macrophages (HP:0004311)2.62391449
20Myocardial infarction (HP:0001658)2.61896527
21Purpura (HP:0000979)2.60615032
22Elevated erythrocyte sedimentation rate (HP:0003565)2.52412455
23Chronic otitis media (HP:0000389)2.50051802
24Spontaneous hematomas (HP:0007420)2.49269336
25Cellulitis (HP:0100658)2.47955225
26Vertebral compression fractures (HP:0002953)2.47482257
27Increased cerebral lipofuscin (HP:0011813)2.46915195
28Peritonitis (HP:0002586)2.37342049
29Dysostosis multiplex (HP:0000943)2.37258988
30Autoimmune thrombocytopenia (HP:0001973)2.36256438
31Increased mean platelet volume (HP:0011877)2.35963951
32Amyloidosis (HP:0011034)2.35336161
33Epistaxis (HP:0000421)2.29727598
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.27171027
35Fatigue (HP:0012378)2.23690408
36Myositis (HP:0100614)2.21212973
37Gingival bleeding (HP:0000225)2.17353342
38Recurrent viral infections (HP:0004429)2.16446405
39Impaired platelet aggregation (HP:0003540)2.14270934
40Abnormal platelet function (HP:0011869)2.14270934
41Spondylolisthesis (HP:0003302)2.13963512
42Soft skin (HP:0000977)2.12512043
43Metaphyseal cupping (HP:0003021)2.12234591
44Stomatitis (HP:0010280)2.12150927
45Dilatation of the ascending aorta (HP:0005111)2.11378948
46Atrophic scars (HP:0001075)2.11104581
47Urinary glycosaminoglycan excretion (HP:0003541)2.06393745
48Mucopolysacchariduria (HP:0008155)2.06393745
49Distal lower limb muscle weakness (HP:0009053)2.05606309
50Urticaria (HP:0001025)2.02751196
51Upper motor neuron abnormality (HP:0002127)2.01362945
52Pustule (HP:0200039)2.01323443
53Abnormality of skeletal muscle fiber size (HP:0012084)2.00994848
54Shallow orbits (HP:0000586)2.00806678
55Nonimmune hydrops fetalis (HP:0001790)2.00353353
56Ulnar bowing (HP:0003031)1.95890543
57Recurrent fungal infections (HP:0002841)1.95830869
58Blue sclerae (HP:0000592)1.93676133
59Wormian bones (HP:0002645)1.91916287
60Progressive neurologic deterioration (HP:0002344)1.91715301
61Recurrent cutaneous fungal infections (HP:0011370)1.88371890
62Chronic mucocutaneous candidiasis (HP:0002728)1.88371890
63IgM deficiency (HP:0002850)1.87986553
64Menorrhagia (HP:0000132)1.87387540
65Nuclear cataract (HP:0100018)1.86061739
66Recurrent gram-negative bacterial infections (HP:0005420)1.85685085
67Thoracolumbar scoliosis (HP:0002944)1.84240783
68Joint stiffness (HP:0001387)1.84151855
69Abnormality of skull ossification (HP:0002703)1.83948680
70Amaurosis fugax (HP:0100576)1.83532867
71Osteomyelitis (HP:0002754)1.82788469
72Increased IgM level (HP:0003496)1.82372897
73Vascular tortuosity (HP:0004948)1.81989875
74Meningitis (HP:0001287)1.80597930
75Abnormality of the distal phalanges of the toes (HP:0010182)1.80307172
76Recurrent skin infections (HP:0001581)1.80136726
77Mucosal telangiectasiae (HP:0100579)1.79469108
78Platyspondyly (HP:0000926)1.78802798
79Abnormality of the nasal mucosa (HP:0000433)1.77990599
80Hypergammaglobulinemia (HP:0010702)1.77891697
81Orthostatic hypotension (HP:0001278)1.77082282
82Chest pain (HP:0100749)1.76775381
83Pulmonary infiltrates (HP:0002113)1.76522309
84Genu recurvatum (HP:0002816)1.76113532
85Emphysema (HP:0002097)1.75589418
86Increased density of long bones (HP:0006392)1.75402892
87Disinhibition (HP:0000734)1.75386110
88Abnormality of the calcaneus (HP:0008364)1.75026890
89Abnormality of T cell physiology (HP:0011840)1.74982723
90Thrombocytosis (HP:0001894)1.73811406
91Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73767041
92Abnormality of polysaccharide metabolism (HP:0011012)1.73767041
93Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73767041
94Broad face (HP:0000283)1.73764434
95Vertebral hypoplasia (HP:0008417)1.73517134
96Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.73517134
97Persistence of primary teeth (HP:0006335)1.72353850
98Arterial tortuosity (HP:0005116)1.71998719
99Skin ulcer (HP:0200042)1.71533586
100Abnormality of the peritoneum (HP:0002585)1.71501640
101Increased variability in muscle fiber diameter (HP:0003557)1.71336531
102Systemic lupus erythematosus (HP:0002725)1.71108524
103Increased IgE level (HP:0003212)1.70961868
104Abnormal delayed hypersensitivity skin test (HP:0002963)1.70947372
105Recurrent bronchitis (HP:0002837)1.70944801
106Abnormal foot bone ossification (HP:0010675)1.70625216
107Abnormality of the acetabulum (HP:0003170)1.70606430
108Obstructive lung disease (HP:0006536)1.70579794
109Chronic obstructive pulmonary disease (HP:0006510)1.70579794
110Abnormality of the vasculature of the conjunctiva (HP:0008054)1.70228449
111Thin bony cortex (HP:0002753)1.69999773
112Beaking of vertebral bodies (HP:0004568)1.69514964
113Tetraparesis (HP:0002273)1.68722145
114Reduced subcutaneous adipose tissue (HP:0003758)1.68608873
115Mediastinal lymphadenopathy (HP:0100721)1.67163427
116Bicuspid aortic valve (HP:0001647)1.65515978
117Decreased skull ossification (HP:0004331)1.65498635
118Vasculitis (HP:0002633)1.64993335
119Increased CSF protein (HP:0002922)1.64672915
120Short nail (HP:0001799)1.63362153
121Hypertensive crisis (HP:0100735)1.62776143
122Abnormal vertebral ossification (HP:0100569)1.62255206
123Abnormality of T cell number (HP:0011839)1.62170349
124Petechiae (HP:0000967)1.60136552
125Abnormality of T cells (HP:0002843)1.59976752
126Flat acetabular roof (HP:0003180)1.58352105
127Poor head control (HP:0002421)1.58276159
128Axonal loss (HP:0003447)1.58244838
129T lymphocytopenia (HP:0005403)1.58179914
130Abnormality of glycolipid metabolism (HP:0010969)1.56899530
131Abnormality of liposaccharide metabolism (HP:0010968)1.56899530
132Abnormality of glycosphingolipid metabolism (HP:0004343)1.56899530
133Abnormal platelet volume (HP:0011876)1.56389995
134Abnormality of the lumbar spine (HP:0100712)1.56242488
135Leukocytosis (HP:0001974)1.55643273
136Mitral valve prolapse (HP:0001634)1.55438021
137Eosinophilia (HP:0001880)1.54948744
138Gingivitis (HP:0000230)1.54751265
139Camptodactyly of toe (HP:0001836)1.54546068
140Syringomyelia (HP:0003396)1.54187536
141Spinal cord lesions (HP:0100561)1.54187536
142Epiphyseal dysplasia (HP:0002656)1.53603863
143Orchitis (HP:0100796)1.53272158
144Polycythemia (HP:0001901)1.53027903

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB32.62040890
2ERN12.54068537
3PRPF4B2.46900268
4STK102.46243825
5NME22.36238266
6MAP4K12.31314711
7LRRK22.28607222
8RIPK42.24962723
9EPHB12.24039101
10TESK22.17090899
11TGFBR21.98700013
12SIK31.89741624
13MOS1.85308228
14BMPR21.84527561
15SMG11.78626274
16KDR1.78178197
17MST41.74763801
18PKN21.71260533
19BLK1.68280190
20RPS6KA41.65730048
21TESK11.59911133
22PAK41.59285415
23MAP3K121.59278693
24JAK31.56006241
25TBK11.53473156
26TTN1.51304806
27MAP3K101.48254494
28ZAP701.47169900
29FLT31.46501404
30TYK21.44053100
31MYLK1.42038547
32SCYL21.40056580
33MAP3K131.38625424
34PIM21.34439586
35MAP3K31.32915611
36NEK91.31131576
37KIT1.27253885
38CSK1.25889634
39IRAK41.23558605
40FES1.23366226
41MAP2K31.17242963
42PTK61.16896907
43EPHA21.15880060
44CSF1R1.15639654
45LIMK11.15054744
46BRSK21.13621355
47VRK21.12795853
48ARAF1.10501881
49MAP3K81.09881026
50MAP3K141.09017227
51EEF2K1.05872023
52BTK1.05720171
53TGFBR11.04513377
54WEE11.04037192
55TRPM71.03547912
56FGR1.03077546
57YES11.02531662
58EPHA31.02354374
59ITK1.01284185
60CLK10.97121892
61PIM10.96491162
62IKBKB0.93499253
63TEC0.91425407
64PASK0.91086970
65CDK60.91001802
66PIK3CG0.90266652
67FGFR40.90083022
68ILK0.89730310
69KSR20.89302089
70BUB10.88727370
71JAK10.87829336
72IRAK30.87598035
73SIK10.87506127
74STK40.87493156
75STK30.86963584
76PAK20.86528855
77EIF2AK10.86409053
78MET0.84453625
79RPS6KB20.81794198
80MAP3K10.81686313
81PDGFRA0.78618806
82NLK0.78592270
83PBK0.75303159
84TIE10.74542792
85NEK20.73394830
86PDK20.72092622
87CHUK0.71591543
88NEK10.70796672
89PRKG20.70303555
90DDR20.69741824
91MAPKAPK20.69299236
92MARK30.69033193
93MAP2K20.68439120
94PTK20.68295521
95BMX0.67941612
96EIF2AK30.67350879
97MAP3K110.65654121
98IKBKE0.64266720
99LCK0.64076073
100TXK0.64055835
101MAPKAPK30.63441178
102CDK120.63170524
103ERBB40.61799152
104LATS10.61796470
105HCK0.60888956
106SYK0.59831171
107DYRK1B0.58063971
108ROCK20.56928135
109DMPK0.56411589
110GRK60.56114470
111ABL20.56027671
112RIPK10.55918233
113FGFR30.55135400
114CDK40.55062718
115PDGFRB0.53783226
116STK240.53733192
117TAOK30.53063042
118CAMK1D0.52887734
119RAF10.52471331
120MAP3K50.52441123
121TAOK10.50252011
122ALK0.48337168
123LYN0.48176525
124JAK20.48140337
125ACVR1B0.47273657
126CDK70.45735756
127CDK90.43138191
128GSK3A0.42862506
129TAOK20.42096497
130PAK10.42018474
131TRIM280.41462782
132MELK0.38706705
133FER0.38137968
134CDC42BPA0.37663642

Predicted pathways (KEGG)

RankGene SetZ-score
1Antigen processing and presentation_Homo sapiens_hsa046122.16861270
2Leishmaniasis_Homo sapiens_hsa051402.14253530
3* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.85799186
4Lysosome_Homo sapiens_hsa041421.79727859
5Shigellosis_Homo sapiens_hsa051311.78837174
6* Leukocyte transendothelial migration_Homo sapiens_hsa046701.78182698
7* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.68042648
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67254509
9Legionellosis_Homo sapiens_hsa051341.65331828
10DNA replication_Homo sapiens_hsa030301.64822878
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.64142245
12Malaria_Homo sapiens_hsa051441.62995806
13Small cell lung cancer_Homo sapiens_hsa052221.53712199
14Osteoclast differentiation_Homo sapiens_hsa043801.50471532
15ECM-receptor interaction_Homo sapiens_hsa045121.50130824
16Toxoplasmosis_Homo sapiens_hsa051451.49865113
17Viral myocarditis_Homo sapiens_hsa054161.46819583
18Autoimmune thyroid disease_Homo sapiens_hsa053201.45177692
19Primary immunodeficiency_Homo sapiens_hsa053401.44196994
20Other glycan degradation_Homo sapiens_hsa005111.42219557
21Measles_Homo sapiens_hsa051621.40177413
22B cell receptor signaling pathway_Homo sapiens_hsa046621.39065421
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.37691712
24Apoptosis_Homo sapiens_hsa042101.37684887
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36502654
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35767439
27Chronic myeloid leukemia_Homo sapiens_hsa052201.30732819
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30210049
29Hematopoietic cell lineage_Homo sapiens_hsa046401.29025089
30Protein export_Homo sapiens_hsa030601.28884350
31p53 signaling pathway_Homo sapiens_hsa041151.28218406
32* Focal adhesion_Homo sapiens_hsa045101.28031545
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24869871
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23905134
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20359414
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19760929
37* Pertussis_Homo sapiens_hsa051331.17902380
38* Adherens junction_Homo sapiens_hsa045201.17606070
39Staphylococcus aureus infection_Homo sapiens_hsa051501.16623593
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15963976
41Herpes simplex infection_Homo sapiens_hsa051681.14464486
42Salmonella infection_Homo sapiens_hsa051321.10364085
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10179682
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.09032340
45Pancreatic cancer_Homo sapiens_hsa052121.08980289
46Cell cycle_Homo sapiens_hsa041101.05715057
47* Proteoglycans in cancer_Homo sapiens_hsa052051.05104843
48* Viral carcinogenesis_Homo sapiens_hsa052031.04853616
49Vibrio cholerae infection_Homo sapiens_hsa051101.04519946
50Hepatitis B_Homo sapiens_hsa051611.03991795
51Galactose metabolism_Homo sapiens_hsa000521.01468609
52* Tuberculosis_Homo sapiens_hsa051521.00949347
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.00340676
54TNF signaling pathway_Homo sapiens_hsa046681.00030634
55Type I diabetes mellitus_Homo sapiens_hsa049400.99277631
56Proteasome_Homo sapiens_hsa030500.99091181
57Amoebiasis_Homo sapiens_hsa051460.97944136
58Ribosome_Homo sapiens_hsa030100.96784189
59Phagosome_Homo sapiens_hsa041450.96213262
60Graft-versus-host disease_Homo sapiens_hsa053320.95852476
61Acute myeloid leukemia_Homo sapiens_hsa052210.94207686
62Epstein-Barr virus infection_Homo sapiens_hsa051690.94135643
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93936322
64HTLV-I infection_Homo sapiens_hsa051660.92961498
65Base excision repair_Homo sapiens_hsa034100.92423429
66Influenza A_Homo sapiens_hsa051640.92300554
67Non-small cell lung cancer_Homo sapiens_hsa052230.90065152
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88946072
69Mismatch repair_Homo sapiens_hsa034300.88164362
70* MicroRNAs in cancer_Homo sapiens_hsa052060.87872882
71Fatty acid elongation_Homo sapiens_hsa000620.87732735
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87584745
73* Platelet activation_Homo sapiens_hsa046110.85773000
74Sulfur metabolism_Homo sapiens_hsa009200.85631532
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85348179
76Caffeine metabolism_Homo sapiens_hsa002320.82668005
77Spliceosome_Homo sapiens_hsa030400.81022839
78* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80991305
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80861942
80Notch signaling pathway_Homo sapiens_hsa043300.80208841
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79768203
82Thyroid cancer_Homo sapiens_hsa052160.78534045
83Allograft rejection_Homo sapiens_hsa053300.77161544
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.77030463
85N-Glycan biosynthesis_Homo sapiens_hsa005100.76598325
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74842078
87Renin-angiotensin system_Homo sapiens_hsa046140.73159213
88Bladder cancer_Homo sapiens_hsa052190.72459004
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71230666
90* Endocytosis_Homo sapiens_hsa041440.69869562
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68916909
92Prostate cancer_Homo sapiens_hsa052150.68784014
93Renal cell carcinoma_Homo sapiens_hsa052110.68108453
94Protein digestion and absorption_Homo sapiens_hsa049740.67722566
95* Chemokine signaling pathway_Homo sapiens_hsa040620.67440861
96* T cell receptor signaling pathway_Homo sapiens_hsa046600.64993200
97Hepatitis C_Homo sapiens_hsa051600.64964592
98Carbon metabolism_Homo sapiens_hsa012000.63799417
99* Pathways in cancer_Homo sapiens_hsa052000.62576621
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62494443
101RNA transport_Homo sapiens_hsa030130.61937742
102Pentose phosphate pathway_Homo sapiens_hsa000300.58425888
103Non-homologous end-joining_Homo sapiens_hsa034500.57923444
104Nucleotide excision repair_Homo sapiens_hsa034200.57636558
105Endometrial cancer_Homo sapiens_hsa052130.56492384
106* Sphingolipid signaling pathway_Homo sapiens_hsa040710.56258989
107One carbon pool by folate_Homo sapiens_hsa006700.56060071
108* TGF-beta signaling pathway_Homo sapiens_hsa043500.55652494
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55505371
110Folate biosynthesis_Homo sapiens_hsa007900.54762467
111Asthma_Homo sapiens_hsa053100.53078018
112Sphingolipid metabolism_Homo sapiens_hsa006000.52564049
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52415994
114Selenocompound metabolism_Homo sapiens_hsa004500.51086917
115Biosynthesis of amino acids_Homo sapiens_hsa012300.49491056
116Hippo signaling pathway_Homo sapiens_hsa043900.49300791
117Glutathione metabolism_Homo sapiens_hsa004800.48419889
118African trypanosomiasis_Homo sapiens_hsa051430.48019233
119HIF-1 signaling pathway_Homo sapiens_hsa040660.47964253
120Rheumatoid arthritis_Homo sapiens_hsa053230.46269415
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46159827

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