RHOB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.43356448
2central nervous system myelination (GO:0022010)5.43356448
3positive regulation of chemokine secretion (GO:0090197)4.46469395
4microglial cell activation (GO:0001774)4.37886902
5ensheathment of neurons (GO:0007272)3.97751481
6axon ensheathment (GO:0008366)3.97751481
7myelination (GO:0042552)3.91629145
8peptidyl-tyrosine autophosphorylation (GO:0038083)3.47907132
9protein localization to endosome (GO:0036010)3.41881071
10regulation of chemokine secretion (GO:0090196)3.28428774
11synaptic vesicle maturation (GO:0016188)3.28305282
12myelin maintenance (GO:0043217)3.27998034
13negative regulation of fatty acid transport (GO:2000192)3.18481760
14cell-cell junction maintenance (GO:0045217)3.12033401
15endothelial cell chemotaxis (GO:0035767)3.09596194
16positive regulation of extracellular matrix organization (GO:1903055)2.99444588
17stress fiber assembly (GO:0043149)2.99110002
18L-amino acid import (GO:0043092)2.96965980
19adenosine receptor signaling pathway (GO:0001973)2.94095352
20negative regulation of fibrinolysis (GO:0051918)2.88493775
21low-density lipoprotein particle clearance (GO:0034383)2.86002274
22cortical actin cytoskeleton organization (GO:0030866)2.83478592
23chondroitin sulfate catabolic process (GO:0030207)2.83000827
24regulation of ARF GTPase activity (GO:0032312)2.82959392
25macrophage activation involved in immune response (GO:0002281)2.82025239
26sodium ion export (GO:0071436)2.79665632
27cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.75549196
28nerve growth factor signaling pathway (GO:0038180)2.75335613
29endothelium development (GO:0003158)2.73814799
30basement membrane organization (GO:0071711)2.69948981
31regulation of complement activation (GO:0030449)2.69352978
32atrioventricular valve morphogenesis (GO:0003181)2.69126965
33response to methylmercury (GO:0051597)2.68427899
34regulation of cholesterol biosynthetic process (GO:0045540)2.66819409
35positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.66624232
36regulation of p38MAPK cascade (GO:1900744)2.66444977
37regulation of protein activation cascade (GO:2000257)2.66434549
38import into cell (GO:0098657)2.66165732
39cytoskeletal anchoring at plasma membrane (GO:0007016)2.66128316
40astrocyte development (GO:0014002)2.64032950
41cortical cytoskeleton organization (GO:0030865)2.63401343
42virion attachment to host cell (GO:0019062)2.61959692
43adhesion of symbiont to host cell (GO:0044650)2.61959692
44insulin-like growth factor receptor signaling pathway (GO:0048009)2.58842032
45oligodendrocyte differentiation (GO:0048709)2.57571028
46adherens junction assembly (GO:0034333)2.57514398
47cell junction maintenance (GO:0034331)2.57101565
48myelination in peripheral nervous system (GO:0022011)2.55143302
49peripheral nervous system axon ensheathment (GO:0032292)2.55143302
50G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.55061941
51glycine transport (GO:0015816)2.55007055
52negative regulation of catenin import into nucleus (GO:0035414)2.54919549
53response to lipoprotein particle (GO:0055094)2.53453868
54complement activation, alternative pathway (GO:0006957)2.51246536
55positive regulation of osteoblast proliferation (GO:0033690)2.51235231
56creatine metabolic process (GO:0006600)2.50829650
57vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.48639725
58regulation of synapse structural plasticity (GO:0051823)2.48308802
59regulation of apoptotic cell clearance (GO:2000425)2.47723306
60membrane tubulation (GO:0097320)2.47510617
61negative regulation of inclusion body assembly (GO:0090084)2.47116688
62negative regulation of neurotransmitter secretion (GO:0046929)2.45928015
63monocyte differentiation (GO:0030224)2.45702130
64neuron remodeling (GO:0016322)2.43627962
65keratan sulfate catabolic process (GO:0042340)2.43491444
66embryonic process involved in female pregnancy (GO:0060136)2.42499018
67negative regulation of protein localization to cell surface (GO:2000009)2.42071603
68endocrine hormone secretion (GO:0060986)2.40598894
69positive regulation of p38MAPK cascade (GO:1900745)2.38855638
70modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.38621018
71positive regulation by organism of defense response of other organism involved in symbiotic interact2.38621018
72modulation by symbiont of host immune response (GO:0052553)2.38621018
73positive regulation by symbiont of host defense response (GO:0052509)2.38621018
74modulation by symbiont of host defense response (GO:0052031)2.38621018
75modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.38621018
76layer formation in cerebral cortex (GO:0021819)2.38290972
77cellular response to epinephrine stimulus (GO:0071872)2.38051715
78surfactant homeostasis (GO:0043129)2.37773213
79regulation of fibrinolysis (GO:0051917)2.36875269
80adult walking behavior (GO:0007628)2.36759289
81amino acid import (GO:0043090)2.36513462
82vascular endothelial growth factor signaling pathway (GO:0038084)2.35544495
83negative regulation of neurotransmitter transport (GO:0051589)2.34482538
84L-serine transport (GO:0015825)2.33870842
85regulation of extracellular matrix organization (GO:1903053)2.33346175
86cellular potassium ion homeostasis (GO:0030007)2.33057942
87lymphangiogenesis (GO:0001946)2.32810183
88cell volume homeostasis (GO:0006884)2.32344936
89synaptic vesicle docking involved in exocytosis (GO:0016081)2.32098314
90locomotory exploration behavior (GO:0035641)2.31355779
91negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.31184295
92positive regulation of Rap GTPase activity (GO:0032854)2.31160580
93cerebellar granule cell differentiation (GO:0021707)2.30460953
94lymph vessel development (GO:0001945)2.30043342
95glycerophospholipid catabolic process (GO:0046475)2.29704789
96regulation of plasminogen activation (GO:0010755)2.29297427
97blood vessel endothelial cell migration (GO:0043534)2.28240040
98dendrite morphogenesis (GO:0048813)2.27574074
99macrophage activation (GO:0042116)2.27140712
100retina vasculature morphogenesis in camera-type eye (GO:0061299)2.26573904
101potassium ion import (GO:0010107)2.26346996
102axon development (GO:0061564)2.26070702
103cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.25881560
104cellular response to antibiotic (GO:0071236)2.25669666
105positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.25479071
106pathway-restricted SMAD protein phosphorylation (GO:0060389)2.25189417
107G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.25079164
108negative regulation of blood vessel endothelial cell migration (GO:0043537)2.24690099
109negative regulation of axonogenesis (GO:0050771)2.24614587
110regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.24585228
111focal adhesion assembly (GO:0048041)2.24367996
112cell-substrate adherens junction assembly (GO:0007045)2.24367996
113negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.23881382
114cardiac muscle cell proliferation (GO:0060038)2.23105786
115regulation of cholesterol homeostasis (GO:2000188)2.23085937
116regulation of Rap GTPase activity (GO:0032317)2.22419552
117glucocorticoid biosynthetic process (GO:0006704)2.21569331
118glucocorticoid metabolic process (GO:0008211)2.21252161
119endocardial cushion morphogenesis (GO:0003203)2.20885653
120positive regulation of protein tyrosine kinase activity (GO:0061098)2.20573475
121cellular response to nerve growth factor stimulus (GO:1990090)2.20396128
122response to nerve growth factor (GO:1990089)2.20396128
123neuromuscular process controlling balance (GO:0050885)2.19878601
124cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.19427093
125positive regulation of blood vessel endothelial cell migration (GO:0043536)2.19035220
126regulation of interferon-beta biosynthetic process (GO:0045357)2.18744013
127fatty acid elongation (GO:0030497)2.18434800
128dendritic spine morphogenesis (GO:0060997)2.17977009
129positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.16077838
130cellular sodium ion homeostasis (GO:0006883)2.15781603
131regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.14821925
132neuron projection regeneration (GO:0031102)2.14549112
133negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.13382145
134sodium-independent organic anion transport (GO:0043252)2.12716852
135ruffle organization (GO:0031529)2.12704198
136semaphorin-plexin signaling pathway (GO:0071526)2.12225935
137adhesion of symbiont to host (GO:0044406)2.11803667
138response to auditory stimulus (GO:0010996)2.11736599
139regulation of chemokine-mediated signaling pathway (GO:0070099)2.11616112
140synaptic vesicle exocytosis (GO:0016079)2.11079678
141regulation of collateral sprouting (GO:0048670)2.08707619
142positive regulation of receptor recycling (GO:0001921)2.08563276
143regulation of amyloid precursor protein catabolic process (GO:1902991)2.07797081
144detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.07457515
145detection of temperature stimulus involved in sensory perception (GO:0050961)2.07457515
146glomerular filtration (GO:0003094)2.07282337
147peptidyl-glutamic acid carboxylation (GO:0017187)2.07154285
148protein carboxylation (GO:0018214)2.07154285
149response to fluid shear stress (GO:0034405)2.06778459
150response to cholesterol (GO:0070723)2.06255974
151negative regulation of Rho protein signal transduction (GO:0035024)2.06029425
152serine transport (GO:0032329)2.05697122
153embryonic retina morphogenesis in camera-type eye (GO:0060059)2.05488094
154negative regulation of axon extension (GO:0030517)2.04956852
155glutamate secretion (GO:0014047)2.04918336
156platelet-derived growth factor receptor signaling pathway (GO:0048008)2.04720702
157long-chain fatty acid biosynthetic process (GO:0042759)2.04652195
158regulation of ARF protein signal transduction (GO:0032012)2.04556089
159regulation of actin cytoskeleton reorganization (GO:2000249)2.03979546
160cellular response to monoamine stimulus (GO:0071868)2.03954428
161cellular response to catecholamine stimulus (GO:0071870)2.03954428
162negative regulation of myoblast differentiation (GO:0045662)2.03952915
163response to laminar fluid shear stress (GO:0034616)2.03903052
164cell-substrate junction assembly (GO:0007044)2.03784244
165regulation of extracellular matrix disassembly (GO:0010715)2.03495683
166positive regulation of astrocyte differentiation (GO:0048711)2.03155427
167response to mineralocorticoid (GO:0051385)2.02844467
168embryonic camera-type eye morphogenesis (GO:0048596)2.02594034
169negative regulation of granulocyte differentiation (GO:0030853)2.02458209
170regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.02442864
171heart valve morphogenesis (GO:0003179)2.02323245
172regulation of beta-amyloid formation (GO:1902003)2.02150018
173regulation of blood vessel endothelial cell migration (GO:0043535)2.01536429
174regulation of glucose import in response to insulin stimulus (GO:2001273)2.01359164
175activation of protein kinase A activity (GO:0034199)2.01073596
176negative regulation of protein activation cascade (GO:2000258)2.00715268
177purinergic receptor signaling pathway (GO:0035587)2.00596105
178SMAD protein signal transduction (GO:0060395)2.00246233
179renal absorption (GO:0070293)1.99419942
180cell communication by electrical coupling (GO:0010644)1.98940616
181negative regulation of endothelial cell migration (GO:0010596)1.98853986
182negative regulation of lipid transport (GO:0032369)1.98397257
183cell proliferation involved in kidney development (GO:0072111)1.97336994
184positive regulation of fatty acid beta-oxidation (GO:0032000)1.96611973
185peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)1.96062087
186heart trabecula formation (GO:0060347)1.95483119
187epithelial cell differentiation involved in prostate gland development (GO:0060742)1.95350664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human2.52219819
2RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44295083
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32207383
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.27496229
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.21016876
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18457886
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18457886
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12142562
9* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05644558
10* PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03165062
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99528401
12JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98473711
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98305706
14DROSHA_22980978_ChIP-Seq_HELA_Human1.97766374
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96971756
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93594588
17EZH2_22144423_ChIP-Seq_EOC_Human1.88115505
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.82290843
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81746138
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77628455
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.76519665
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.76145207
23RACK7_27058665_Chip-Seq_MCF-7_Human1.70971806
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.70925661
25GBX2_23144817_ChIP-Seq_PC3_Human1.70528349
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.67716598
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.66449606
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.63303766
29* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60780421
30* ESR2_21235772_ChIP-Seq_MCF-7_Human1.59575351
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59289699
32AR_21572438_ChIP-Seq_LNCaP_Human1.55334194
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.54019757
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52237255
35* LXR_22158963_ChIP-Seq_LIVER_Mouse1.50614122
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49711309
37* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46760228
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46546420
39ZNF263_19887448_ChIP-Seq_K562_Human1.46414041
40KDM2B_26808549_Chip-Seq_K562_Human1.44209347
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43939556
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42949820
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42583601
44* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40867901
45* TCF7_22412390_ChIP-Seq_EML_Mouse1.40098348
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39705623
47* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38871249
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38644738
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.37559151
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.37007852
51* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36990147
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36903348
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36503531
54* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35709761
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34469591
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34022781
57* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32809402
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31271913
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30137610
60* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28165478
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.28158992
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.27397542
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.23709462
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23245994
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19725679
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19261500
67* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18675343
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18568335
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18389882
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14909092
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14908474
72AHR_22903824_ChIP-Seq_MCF-7_Human1.13828536
73GATA1_19941826_ChIP-Seq_K562_Human1.13226372
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.11849123
75VDR_24787735_ChIP-Seq_THP-1_Human1.08973650
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08882846
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.08157856
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.07980796
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07690411
80CREB1_26743006_Chip-Seq_LNCaP_Human1.07665790
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07567628
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.06645580
83* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06560453
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05815049
85TP53_16413492_ChIP-PET_HCT116_Human1.05472456
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05446246
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04878014
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04835943
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04800835
90KDM2B_26808549_Chip-Seq_DND41_Human1.04489697
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.04391092
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03550901
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03405890
94* RING1B_27294783_Chip-Seq_NPCs_Mouse1.01862126
95* RING1B_27294783_Chip-Seq_ESCs_Mouse1.01721258
96FOXO3_23340844_ChIP-Seq_DLD1_Human1.01713734
97SPI1_23127762_ChIP-Seq_K562_Human1.01264891
98* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98826001
99RUNX_20019798_ChIP-Seq_JUKART_Human0.98498634
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98414496
101NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98414496
102* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98267038
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98265742
104* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97828224
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97555767
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95379987
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95049167
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.94996456
109BP1_19119308_ChIP-ChIP_Hs578T_Human0.94788111
110EGR1_19374776_ChIP-ChIP_THP-1_Human0.94753931
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94369223
112SMC4_20622854_ChIP-Seq_HELA_Human0.93972952
113* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92781506
114* LXR_22292898_ChIP-Seq_THP-1_Human0.92543548
115CJUN_26792858_Chip-Seq_BT549_Human0.92257258
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91773048
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.91557201
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91425212
119REST_21632747_ChIP-Seq_MESCs_Mouse0.91366956
120ELK3_25401928_ChIP-Seq_HUVEC_Human0.90753092
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90202760
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90131429
123KDM2B_26808549_Chip-Seq_JURKAT_Human0.89622337
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89534094
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.89256863
126* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88671832
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87896680
128SMAD3_21741376_ChIP-Seq_EPCs_Human0.87591525
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.86893951
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.86830955
131SCL_19346495_ChIP-Seq_HPC-7_Human0.85504241
132ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85405074
133CLOCK_20551151_ChIP-Seq_293T_Human0.84858647
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84496826
135SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83656295
136TBX20_22080862_ChIP-Seq_HEART_Mouse0.82923386
137TBX20_22328084_ChIP-Seq_HEART_Mouse0.82923386
138KLF5_25053715_ChIP-Seq_YYC3_Human0.82401679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.76193733
2MP0000920_abnormal_myelination3.64236414
3MP0004859_abnormal_synaptic_plasticity3.48652333
4MP0003690_abnormal_glial_cell3.39299497
5MP0005058_abnormal_lysosome_morphology2.76234600
6MP0003880_abnormal_central_pattern2.58466733
7MP0003191_abnormal_cellular_cholesterol2.58125244
8MP0004270_analgesia2.53209298
9MP0006082_CNS_inflammation2.50016847
10MP0005167_abnormal_blood-brain_barrier2.45942593
11MP0003075_altered_response_to2.26216700
12MP0003172_abnormal_lysosome_physiology2.23466754
13MP0002064_seizures2.20046079
14MP0001879_abnormal_lymphatic_vessel2.14404283
15MP0003634_abnormal_glial_cell2.13339576
16MP0004885_abnormal_endolymph2.10931282
17MP0008438_abnormal_cutaneous_collagen2.04113018
18MP0003329_amyloid_beta_deposits1.97074687
19MP0003303_peritoneal_inflammation1.96805010
20MP0003635_abnormal_synaptic_transmissio1.94796086
21MP0005076_abnormal_cell_differentiation1.92461397
22MP0005670_abnormal_white_adipose1.85527548
23MP0003633_abnormal_nervous_system1.76111625
24MP0004185_abnormal_adipocyte_glucose1.75447685
25MP0005623_abnormal_meninges_morphology1.74595778
26MP0003828_pulmonary_edema1.67302360
27MP0001851_eye_inflammation1.66522025
28* MP0003566_abnormal_cell_adhesion1.65548457
29MP0001486_abnormal_startle_reflex1.64483575
30MP0009745_abnormal_behavioral_response1.60130105
31MP0000747_muscle_weakness1.57203879
32MP0009840_abnormal_foam_cell1.56091652
33MP0004272_abnormal_basement_membrane1.55871922
34* MP0003091_abnormal_cell_migration1.50198254
35MP0002272_abnormal_nervous_system1.47401531
36MP0002249_abnormal_larynx_morphology1.46763505
37MP0003950_abnormal_plasma_membrane1.44107134
38MP0002090_abnormal_vision1.39244395
39MP0002063_abnormal_learning/memory/cond1.37546988
40MP0003279_aneurysm1.36224930
41MP0010329_abnormal_lipoprotein_level1.36202383
42MP0003879_abnormal_hair_cell1.35224961
43MP0000604_amyloidosis1.33481645
44MP0003631_nervous_system_phenotype1.33408328
45MP0004858_abnormal_nervous_system1.32591240
46MP0001502_abnormal_circadian_rhythm1.31091026
47MP0005023_abnormal_wound_healing1.29936372
48MP0003045_fibrosis1.29771626
49MP0004782_abnormal_surfactant_physiolog1.29036725
50MP0002896_abnormal_bone_mineralization1.28308158
51MP0002909_abnormal_adrenal_gland1.28306205
52MP0005171_absent_coat_pigmentation1.27387289
53MP0000751_myopathy1.27105879
54MP0001958_emphysema1.26342069
55MP0005423_abnormal_somatic_nervous1.26076989
56MP0003300_gastrointestinal_ulcer1.24432150
57MP0005275_abnormal_skin_tensile1.22201119
58MP0000566_synostosis1.19499900
59MP0002572_abnormal_emotion/affect_behav1.18690372
60MP0000778_abnormal_nervous_system1.18566293
61MP0001501_abnormal_sleep_pattern1.18150801
62MP0000249_abnormal_blood_vessel1.17852372
63MP0004510_myositis1.17595454
64MP0001970_abnormal_pain_threshold1.17337078
65MP0002971_abnormal_brown_adipose1.16729235
66MP0008004_abnormal_stomach_pH1.14624319
67MP0004130_abnormal_muscle_cell1.13264814
68MP0009780_abnormal_chondrocyte_physiolo1.12700087
69MP0003868_abnormal_feces_composition1.12689127
70MP0000343_altered_response_to1.12109278
71MP0008569_lethality_at_weaning1.12043252
72MP0005375_adipose_tissue_phenotype1.12038148
73MP0000013_abnormal_adipose_tissue1.11743052
74MP0005166_decreased_susceptibility_to1.11011100
75MP0002229_neurodegeneration1.10913134
76MP0002009_preneoplasia1.10673922
77MP0001440_abnormal_grooming_behavior1.10535339
78MP0004484_altered_response_of1.10367911
79MP0000749_muscle_degeneration1.09937316
80MP0005503_abnormal_tendon_morphology1.09216752
81MP0004142_abnormal_muscle_tone1.08008357
82MP0000955_abnormal_spinal_cord1.07751840
83MP0002734_abnormal_mechanical_nocicepti1.06077480
84MP0009046_muscle_twitch1.03846584
85MP0002108_abnormal_muscle_morphology1.03670920
86MP0004145_abnormal_muscle_electrophysio1.03158999
87MP0010368_abnormal_lymphatic_system1.03116920
88MP0005666_abnormal_adipose_tissue1.01941722
89MP0002089_abnormal_postnatal_growth/wei1.01286322
90MP0004883_abnormal_blood_vessel1.01266862
91MP0010630_abnormal_cardiac_muscle1.00686556
92MP0004742_abnormal_vestibular_system1.00308749
93MP0008874_decreased_physiological_sensi0.99435554
94MP0005409_darkened_coat_color0.99315557
95MP0000003_abnormal_adipose_tissue0.98521291
96MP0005365_abnormal_bile_salt0.98071198
97MP0003453_abnormal_keratinocyte_physiol0.97945436
98MP0002998_abnormal_bone_remodeling0.97317555
99MP0002933_joint_inflammation0.96768559
100MP0005165_increased_susceptibility_to0.96448387
101MP0005508_abnormal_skeleton_morphology0.96332593
102MP0001905_abnormal_dopamine_level0.94981338
103MP0000534_abnormal_ureter_morphology0.94072095
104MP0002733_abnormal_thermal_nociception0.93397792
105MP0003632_abnormal_nervous_system0.92811259
106MP0010678_abnormal_skin_adnexa0.92600656
107MP0001915_intracranial_hemorrhage0.90396348
108MP0010030_abnormal_orbit_morphology0.90395376
109MP0009384_cardiac_valve_regurgitation0.90243737
110MP0002736_abnormal_nociception_after0.90079877
111MP0001968_abnormal_touch/_nociception0.89831275
112MP0002877_abnormal_melanocyte_morpholog0.89435221
113MP0002066_abnormal_motor_capabilities/c0.89266906
114MP0002882_abnormal_neuron_morphology0.88980117
115MP0004085_abnormal_heartbeat0.88769267
116MP0002295_abnormal_pulmonary_circulatio0.88687468
117MP0001299_abnormal_eye_distance/0.88120747
118MP0000767_abnormal_smooth_muscle0.87607704
119MP0009278_abnormal_bone_marrow0.85828784
120MP0001849_ear_inflammation0.85284009
121MP0000733_abnormal_muscle_development0.84850671
122MP0001533_abnormal_skeleton_physiology0.83941885
123MP0002133_abnormal_respiratory_system0.83815324
124MP0005388_respiratory_system_phenotype0.83815324
125MP0000639_abnormal_adrenal_gland0.83487387
126MP0005595_abnormal_vascular_smooth0.83196145
127MP0004233_abnormal_muscle_weight0.82961960
128MP0008961_abnormal_basal_metabolism0.81521849
129MP0005164_abnormal_response_to0.81382056
130MP0003183_abnormal_peptide_metabolism0.81316288
131MP0004036_abnormal_muscle_relaxation0.80694162
132MP0006138_congestive_heart_failure0.80636520
133MP0004087_abnormal_muscle_fiber0.80472589
134MP0003724_increased_susceptibility_to0.80433069
135MP0004811_abnormal_neuron_physiology0.80117561
136* MP0001614_abnormal_blood_vessel0.79922069
137MP0000462_abnormal_digestive_system0.79080117
138MP0002796_impaired_skin_barrier0.78986133
139MP0002128_abnormal_blood_circulation0.78758212
140MP0002139_abnormal_hepatobiliary_system0.78615969
141MP0002067_abnormal_sensory_capabilities0.78495285
142MP0005646_abnormal_pituitary_gland0.78403857
143MP0002557_abnormal_social/conspecific_i0.77953068
144MP0004084_abnormal_cardiac_muscle0.77743773
145MP0002060_abnormal_skin_morphology0.77327209
146MP0002118_abnormal_lipid_homeostasis0.77206513
147MP0000762_abnormal_tongue_morphology0.76566808
148MP0009115_abnormal_fat_cell0.75286855
149MP0008875_abnormal_xenobiotic_pharmacok0.74837321
150MP0003283_abnormal_digestive_organ0.72931077
151MP0001348_abnormal_lacrimal_gland0.71219099
152MP0000467_abnormal_esophagus_morphology0.66854253
153MP0003942_abnormal_urinary_system0.66294669

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.14661533
2Neurofibrillary tangles (HP:0002185)4.59684396
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.42208477
4Abnormality of glycolipid metabolism (HP:0010969)4.42208477
5Abnormality of liposaccharide metabolism (HP:0010968)4.42208477
6Glomerulonephritis (HP:0000099)4.41945391
7Mutism (HP:0002300)4.36237778
8Arterial tortuosity (HP:0005116)4.25563019
9Cerebral aneurysm (HP:0004944)3.89084687
10Vascular tortuosity (HP:0004948)3.88092581
11Deep venous thrombosis (HP:0002625)3.82517538
12Axonal loss (HP:0003447)3.80907167
13Cerebral inclusion bodies (HP:0100314)3.69378706
14Protrusio acetabuli (HP:0003179)3.67230252
15Supranuclear gaze palsy (HP:0000605)3.55803493
16Increased cerebral lipofuscin (HP:0011813)3.54922434
17Complement deficiency (HP:0004431)3.31973091
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.23400982
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.23400982
20Neuronal loss in central nervous system (HP:0002529)3.22242791
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.17318166
22Myokymia (HP:0002411)3.16128016
23Retinal atrophy (HP:0001105)3.09440602
24Dysostosis multiplex (HP:0000943)3.02718002
25Onion bulb formation (HP:0003383)3.01802096
26Peripheral hypomyelination (HP:0007182)2.89787527
27Disproportionate tall stature (HP:0001519)2.79564535
28Broad face (HP:0000283)2.76930371
29Mitral stenosis (HP:0001718)2.74089222
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.68782721
31Ankle clonus (HP:0011448)2.67327302
32Intention tremor (HP:0002080)2.65705917
33Rapidly progressive (HP:0003678)2.62746309
34Action tremor (HP:0002345)2.61157182
35Arnold-Chiari malformation (HP:0002308)2.61019033
36Aortic dissection (HP:0002647)2.59324492
37Distal lower limb muscle weakness (HP:0009053)2.57623756
38Muscle fiber splitting (HP:0003555)2.56992564
39Bronchomalacia (HP:0002780)2.56154268
40Abnormality of the corticospinal tract (HP:0002492)2.53588406
41Lymphangioma (HP:0100764)2.53463892
42Postural instability (HP:0002172)2.51807752
43Aortic aneurysm (HP:0004942)2.51234776
44Segmental peripheral demyelination/remyelination (HP:0003481)2.43887532
45Hematochezia (HP:0002573)2.42395786
46Hemorrhage of the eye (HP:0011885)2.42107695
47Dysmetria (HP:0001310)2.40647169
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.40410851
49Ulnar bowing (HP:0003031)2.39792087
50Amyloidosis (HP:0011034)2.34636959
51Esophageal varix (HP:0002040)2.33695412
52Hyporeflexia of lower limbs (HP:0002600)2.33547538
53Termporal pattern (HP:0011008)2.32662665
54Insidious onset (HP:0003587)2.32662665
55Joint hemorrhage (HP:0005261)2.32114290
56Shallow orbits (HP:0000586)2.29412417
57Striae distensae (HP:0001065)2.28680314
58Mitral regurgitation (HP:0001653)2.24384325
59Abnormality of complement system (HP:0005339)2.23915382
60Nephritis (HP:0000123)2.22610777
61Urinary incontinence (HP:0000020)2.21376138
62Clumsiness (HP:0002312)2.21184326
63Growth hormone excess (HP:0000845)2.20113427
64Progressive neurologic deterioration (HP:0002344)2.20028909
65Scapular winging (HP:0003691)2.20008902
66Difficulty running (HP:0009046)2.17732462
67Asymmetry of the thorax (HP:0001555)2.16539851
68Premature rupture of membranes (HP:0001788)2.11515118
69Peripheral demyelination (HP:0011096)2.10203199
70Aneurysm (HP:0002617)2.08466771
71Wormian bones (HP:0002645)2.07961947
72Broad metatarsal (HP:0001783)2.06745005
73Loss of speech (HP:0002371)2.06542353
74Centrally nucleated skeletal muscle fibers (HP:0003687)2.06206537
75Achilles tendon contracture (HP:0001771)2.04558774
76Gowers sign (HP:0003391)2.04394115
77Visceral angiomatosis (HP:0100761)2.04005842
78Hypoplasia of the iris (HP:0007676)2.02592197
79Increased connective tissue (HP:0009025)2.02132103
80Cerebral hemorrhage (HP:0001342)2.00961121
81Acanthosis nigricans (HP:0000956)2.00806764
82Hypercortisolism (HP:0001578)1.99958444
83Spinal rigidity (HP:0003306)1.99702329
84Mitral valve prolapse (HP:0001634)1.99600843
85Hyperacusis (HP:0010780)1.98454824
86Aplasia involving bones of the upper limbs (HP:0009823)1.96045375
87Aplasia of the phalanges of the hand (HP:0009802)1.96045375
88Aplasia involving bones of the extremities (HP:0009825)1.96045375
89Split foot (HP:0001839)1.95698759
90Polycythemia (HP:0001901)1.95007016
91Disinhibition (HP:0000734)1.94345648
92Mucopolysacchariduria (HP:0008155)1.93943565
93Urinary glycosaminoglycan excretion (HP:0003541)1.93943565
94Xanthomatosis (HP:0000991)1.93034893
95Spastic gait (HP:0002064)1.91923457
96Overgrowth (HP:0001548)1.91415585
97Sensory axonal neuropathy (HP:0003390)1.90989705
98Depression (HP:0000716)1.90928403
99Choroideremia (HP:0001139)1.89702757
100Obstructive sleep apnea (HP:0002870)1.89168800
101Akinesia (HP:0002304)1.88363088
102Abnormality of the periventricular white matter (HP:0002518)1.88280594
103Abnormal ossification of hand bones (HP:0005921)1.87691871
104Wrist flexion contracture (HP:0001239)1.87643024
105Hepatosplenomegaly (HP:0001433)1.86082090
106Hemangiomatosis (HP:0007461)1.84712329
107Abnormality of the distal phalanx of the thumb (HP:0009617)1.84284512
108Neonatal short-limb short stature (HP:0008921)1.83740605
109Foot dorsiflexor weakness (HP:0009027)1.83599523
110Cervical subluxation (HP:0003308)1.82994097
111Round ear (HP:0100830)1.82903342
112Increased variability in muscle fiber diameter (HP:0003557)1.82280582
113Abnormality of carpal bone ossification (HP:0006257)1.81821527
114EMG: myopathic abnormalities (HP:0003458)1.80752449
115Apathy (HP:0000741)1.79756976
116Neonatal death (HP:0003811)1.79660985
117Flat acetabular roof (HP:0003180)1.78399111
118Venous abnormality (HP:0002624)1.78177718
119Germ cell neoplasia (HP:0100728)1.78121237
120Exotropia (HP:0000577)1.78088565
121Dementia (HP:0000726)1.78051834
122Abnormality of polysaccharide metabolism (HP:0011012)1.77685084
123Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77685084
124Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77685084
125Buphthalmos (HP:0000557)1.77446466
126Premature skin wrinkling (HP:0100678)1.77273304
127Megalencephaly (HP:0001355)1.75480394
128Rigidity (HP:0002063)1.75280909
129Orthostatic hypotension (HP:0001278)1.74767004
130Distal upper limb amyotrophy (HP:0007149)1.74505407
131Upper limb amyotrophy (HP:0009129)1.74505407
132Abnormality of the Achilles tendon (HP:0005109)1.73768982
133Stroke (HP:0001297)1.72083676
134Back pain (HP:0003418)1.72068111
135Hammertoe (HP:0001765)1.71746335
136Distal lower limb amyotrophy (HP:0008944)1.71655726
137Partial duplication of thumb phalanx (HP:0009944)1.71370307
138Dilatation of the ascending aorta (HP:0005111)1.70834452
139Blue sclerae (HP:0000592)1.70800774
140Bowel incontinence (HP:0002607)1.70687078
141Urethral obstruction (HP:0000796)1.70081131
142Alacrima (HP:0000522)1.69987327
143Neoplasm of the heart (HP:0100544)1.69215722
144Hypercholesterolemia (HP:0003124)1.66757906
145Turricephaly (HP:0000262)1.65096176
146Interstitial pulmonary disease (HP:0006530)1.64830410
147Venous insufficiency (HP:0005293)1.64303412
148Menorrhagia (HP:0000132)1.63989823
149Hyperparathyroidism (HP:0000843)1.63380581
150Skin nodule (HP:0200036)1.61764059
151Vertebral compression fractures (HP:0002953)1.61639199
152Spinal cord compression (HP:0002176)1.57554520
153Coxa vara (HP:0002812)1.56655925
154Abnormality of aromatic amino acid family metabolism (HP:0004338)1.55099568
155Stridor (HP:0010307)1.54686907
156Cardiovascular calcification (HP:0011915)1.53841301
157Myocardial infarction (HP:0001658)1.53747427
158Camptodactyly of toe (HP:0001836)1.52389303
159Atrioventricular block (HP:0001678)1.51621234
160J-shaped sella turcica (HP:0002680)1.51598602
161Wide anterior fontanel (HP:0000260)1.50716371
162Difficulty climbing stairs (HP:0003551)1.50068792
163Thin ribs (HP:0000883)1.49735533
164Laryngomalacia (HP:0001601)1.48784802
165Aortic regurgitation (HP:0001659)1.48639387
166Short nail (HP:0001799)1.48398407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.00602128
2TGFBR24.68837445
3STK392.92638891
4SIK12.61345858
5EPHB12.60830110
6GRK72.10289014
7EPHA22.09681480
8OXSR12.06115378
9ERN11.97699010
10FGFR41.96551753
11EEF2K1.93738201
12LATS21.91755174
13MAPKAPK51.84270103
14CAMK1G1.82605610
15CSF1R1.79839207
16PKN11.73040043
17MAP3K91.68653713
18CAMK1D1.65724167
19PKN21.62802138
20NTRK11.59162732
21FGFR21.49576879
22PAK61.45729047
23EPHA41.43857984
24ICK1.42131776
25LIMK11.39301828
26KSR21.36743491
27DMPK1.26703547
28PTK21.26422866
29TIE11.25616953
30CDK121.24950703
31AKT31.24057085
32MOS1.23818610
33MAPKAPK31.23445454
34TYRO31.22347001
35RPS6KA21.21299125
36PAK21.19439595
37CLK11.18563116
38MAP3K31.16481811
39PAK41.15724610
40TSSK61.14884104
41WNK41.13503645
42PRKD11.10507453
43MTOR1.09957598
44WNK11.09283783
45FGFR31.06162194
46PTK2B1.05903647
47FGR1.05577736
48CAMKK11.03908670
49MET1.03842572
50SMG11.03714302
51PRKD31.03427374
52UHMK11.01639665
53MYLK0.98089038
54PDPK10.97451071
55RIPK40.96215583
56EPHB20.96171648
57MARK10.95827241
58SGK30.95306025
59GRK50.95124642
60NEK60.93123625
61CDK50.92670095
62CSNK1A1L0.92414843
63MAPK120.91923461
64MAP3K20.90719948
65PHKG20.90629844
66PHKG10.90629844
67ROCK20.90395931
68CAMK2B0.88941245
69CAMKK20.88602462
70FES0.88096810
71CDK190.86786571
72STK110.84648946
73FER0.83690662
74MAP3K10.83253666
75SGK4940.82465501
76SGK2230.82465501
77TRIB30.82413737
78STK380.82311886
79SGK20.81436802
80MARK20.81036276
81PDK10.80513814
82PDK20.79550574
83MAP2K20.78364451
84DDR20.77963091
85EPHA30.77650913
86CSNK1G30.77577108
87RPS6KC10.77398148
88RPS6KL10.77398148
89RET0.77320174
90PIK3CA0.76719941
91TESK10.76003663
92HIPK20.75580972
93PRKCH0.74683471
94CSNK1G20.73658561
95MAP3K60.73405389
96GSK3A0.72794394
97MAP2K10.71695605
98MAP3K70.70500458
99RIPK10.70223333
100MAPK40.69682147
101DAPK20.69297749
102PRKD20.68367692
103NTRK30.68207280
104TRPM70.68152486
105CAMK2D0.66492143
106TAOK20.64575503
107ROCK10.64399653
108LMTK20.63117245
109BCR0.61762791
110CDC42BPA0.61746405
111MAP2K30.61589950
112CDK140.60665949
113PAK30.60091403
114RPS6KA60.59239173
115CDK150.58665892
116MAPK70.58456072
117NTRK20.58424412
118PDGFRB0.57168193
119TBK10.56928282
120CSNK1G10.56481297
121DYRK1B0.56161336
122PRKAA20.55369321
123MAP3K130.54675103
124PRPF4B0.54467440
125PTK60.54116342
126FYN0.53114572
127CDK180.52800727
128JAK10.52436792
129CAMK40.52166550
130MAPK100.51724473
131MINK10.50830436
132CAMK10.50550466
133TTN0.50548521
134CAMK2A0.49838339
135CAMK2G0.48878994
136CDK11A0.47918573
137TESK20.47574914
138BMX0.47376402
139PRKCE0.47203887
140PRKAA10.46614249
141PDGFRA0.46449430
142TNK20.46188544
143HCK0.46042498
144ERBB20.45906482
145MATK0.45330587
146CDK30.44605047
147PRKG20.39627773
148RPS6KA10.39504199
149LRRK20.38050342

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.41803541
2Complement and coagulation cascades_Homo sapiens_hsa046102.15329261
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04660093
4Glycosaminoglycan degradation_Homo sapiens_hsa005311.96316279
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.96026954
6Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.75863697
7Prion diseases_Homo sapiens_hsa050201.75717415
8Lysosome_Homo sapiens_hsa041421.70508928
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70319855
10Bile secretion_Homo sapiens_hsa049761.65913202
11Other glycan degradation_Homo sapiens_hsa005111.63583760
12Staphylococcus aureus infection_Homo sapiens_hsa051501.54019562
13Phenylalanine metabolism_Homo sapiens_hsa003601.43108530
14Renal cell carcinoma_Homo sapiens_hsa052111.43097996
15Axon guidance_Homo sapiens_hsa043601.42650876
16Salivary secretion_Homo sapiens_hsa049701.40889678
17Cocaine addiction_Homo sapiens_hsa050301.34479186
18Histidine metabolism_Homo sapiens_hsa003401.33368470
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30215408
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29963756
21Arginine biosynthesis_Homo sapiens_hsa002201.27346161
22Circadian entrainment_Homo sapiens_hsa047131.25885796
23Glutamatergic synapse_Homo sapiens_hsa047241.25728098
24Gastric acid secretion_Homo sapiens_hsa049711.25704597
25GABAergic synapse_Homo sapiens_hsa047271.25069913
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24939366
27Renin secretion_Homo sapiens_hsa049241.24861043
28Osteoclast differentiation_Homo sapiens_hsa043801.23414792
29Ether lipid metabolism_Homo sapiens_hsa005651.22262219
30PPAR signaling pathway_Homo sapiens_hsa033201.20758254
31Endocytosis_Homo sapiens_hsa041441.20659032
32Ovarian steroidogenesis_Homo sapiens_hsa049131.20572219
33Morphine addiction_Homo sapiens_hsa050321.19581444
34Estrogen signaling pathway_Homo sapiens_hsa049151.16720731
35Pertussis_Homo sapiens_hsa051331.15935579
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14948292
37Notch signaling pathway_Homo sapiens_hsa043301.14083862
38Synaptic vesicle cycle_Homo sapiens_hsa047211.12045011
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10916975
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09837215
41Dilated cardiomyopathy_Homo sapiens_hsa054141.09680487
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09426017
43Cholinergic synapse_Homo sapiens_hsa047251.05858989
44Gap junction_Homo sapiens_hsa045401.05701540
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05126248
46Olfactory transduction_Homo sapiens_hsa047401.04932647
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.04173002
48Dorso-ventral axis formation_Homo sapiens_hsa043201.03468251
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03422168
50GnRH signaling pathway_Homo sapiens_hsa049121.02511846
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01456548
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01329867
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99799223
54Oxytocin signaling pathway_Homo sapiens_hsa049210.98481388
55Amphetamine addiction_Homo sapiens_hsa050310.97834327
56Long-term potentiation_Homo sapiens_hsa047200.97667230
57Vitamin B6 metabolism_Homo sapiens_hsa007500.97589936
58Long-term depression_Homo sapiens_hsa047300.97282313
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.96817919
60cAMP signaling pathway_Homo sapiens_hsa040240.92634407
61B cell receptor signaling pathway_Homo sapiens_hsa046620.92464291
62AMPK signaling pathway_Homo sapiens_hsa041520.91138916
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90568611
64ECM-receptor interaction_Homo sapiens_hsa045120.90245084
65Endometrial cancer_Homo sapiens_hsa052130.89959585
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89570863
67ErbB signaling pathway_Homo sapiens_hsa040120.89387715
68Rap1 signaling pathway_Homo sapiens_hsa040150.89345092
69Focal adhesion_Homo sapiens_hsa045100.89113049
70Serotonergic synapse_Homo sapiens_hsa047260.88712310
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.86542894
72Dopaminergic synapse_Homo sapiens_hsa047280.86290497
73Insulin signaling pathway_Homo sapiens_hsa049100.86224668
74Amoebiasis_Homo sapiens_hsa051460.82672995
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.82293948
76Platelet activation_Homo sapiens_hsa046110.81616936
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81184850
78Insulin resistance_Homo sapiens_hsa049310.80987860
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.80844117
80MAPK signaling pathway_Homo sapiens_hsa040100.80245542
81Ras signaling pathway_Homo sapiens_hsa040140.79882107
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79351149
83Thyroid hormone synthesis_Homo sapiens_hsa049180.79284596
84Salmonella infection_Homo sapiens_hsa051320.79232239
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78984862
86Chemokine signaling pathway_Homo sapiens_hsa040620.78259707
87Tyrosine metabolism_Homo sapiens_hsa003500.78139944
88Fatty acid elongation_Homo sapiens_hsa000620.77006446
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76987187
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76616816
91Glioma_Homo sapiens_hsa052140.76161752
92Rheumatoid arthritis_Homo sapiens_hsa053230.75199826
93VEGF signaling pathway_Homo sapiens_hsa043700.75042706
94Insulin secretion_Homo sapiens_hsa049110.73947765
95mTOR signaling pathway_Homo sapiens_hsa041500.73503829
96Adherens junction_Homo sapiens_hsa045200.72631156
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72002013
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71775330
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71559115
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.70787355
101Choline metabolism in cancer_Homo sapiens_hsa052310.70530983
102Vibrio cholerae infection_Homo sapiens_hsa051100.69592330
103Phagosome_Homo sapiens_hsa041450.69214947
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68980813
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68759163
106Fatty acid biosynthesis_Homo sapiens_hsa000610.68292420
107Tight junction_Homo sapiens_hsa045300.68087909
108Prolactin signaling pathway_Homo sapiens_hsa049170.67807637
109Type II diabetes mellitus_Homo sapiens_hsa049300.67389191
110Calcium signaling pathway_Homo sapiens_hsa040200.66915885
111Non-small cell lung cancer_Homo sapiens_hsa052230.66753426
112Glucagon signaling pathway_Homo sapiens_hsa049220.65170193
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64847960
114Pancreatic secretion_Homo sapiens_hsa049720.64669816
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.63564487
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62325501
117ABC transporters_Homo sapiens_hsa020100.61977536
118Acute myeloid leukemia_Homo sapiens_hsa052210.61874236
119Bladder cancer_Homo sapiens_hsa052190.61560368
120Inositol phosphate metabolism_Homo sapiens_hsa005620.60875086
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60513940
122Melanogenesis_Homo sapiens_hsa049160.59897829
123Leishmaniasis_Homo sapiens_hsa051400.59117546
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58781392
125HIF-1 signaling pathway_Homo sapiens_hsa040660.58152241
126FoxO signaling pathway_Homo sapiens_hsa040680.57430444
127Circadian rhythm_Homo sapiens_hsa047100.57285551
128TGF-beta signaling pathway_Homo sapiens_hsa043500.55840258
129Pancreatic cancer_Homo sapiens_hsa052120.55352289
130Malaria_Homo sapiens_hsa051440.54727023
131Proteoglycans in cancer_Homo sapiens_hsa052050.54696357
132Tuberculosis_Homo sapiens_hsa051520.54561186
133Toxoplasmosis_Homo sapiens_hsa051450.54019852
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53933553
135Sphingolipid metabolism_Homo sapiens_hsa006000.53678222
136Collecting duct acid secretion_Homo sapiens_hsa049660.53622753
137Hippo signaling pathway_Homo sapiens_hsa043900.53143396
138African trypanosomiasis_Homo sapiens_hsa051430.52621783
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50487441
140Chronic myeloid leukemia_Homo sapiens_hsa052200.50439578

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