RHOBTB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)8.23067623
2actin-myosin filament sliding (GO:0033275)8.23067623
3actin-mediated cell contraction (GO:0070252)7.11512334
4sarcoplasmic reticulum calcium ion transport (GO:0070296)6.99367012
5regulation of skeletal muscle contraction (GO:0014819)6.75839792
6L-phenylalanine catabolic process (GO:0006559)6.12002748
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.12002748
8skeletal muscle contraction (GO:0003009)6.05774873
9L-phenylalanine metabolic process (GO:0006558)5.87800282
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.87800282
11actin filament-based movement (GO:0030048)5.42993210
12aromatic amino acid family catabolic process (GO:0009074)5.26727398
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.25970221
14myofibril assembly (GO:0030239)5.23418789
15lysine catabolic process (GO:0006554)5.05011496
16lysine metabolic process (GO:0006553)5.05011496
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.99748517
18glyoxylate metabolic process (GO:0046487)4.98827239
19response to muscle activity (GO:0014850)4.91131595
20kynurenine metabolic process (GO:0070189)4.86480162
21response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.85720180
22regulation of relaxation of muscle (GO:1901077)4.74753410
23alpha-linolenic acid metabolic process (GO:0036109)4.74598545
24sarcomere organization (GO:0045214)4.67867112
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.58742006
26cardiac myofibril assembly (GO:0055003)4.55765083
27indole-containing compound catabolic process (GO:0042436)4.54369706
28indolalkylamine catabolic process (GO:0046218)4.54369706
29tryptophan catabolic process (GO:0006569)4.54369706
30skeletal muscle fiber development (GO:0048741)4.53696406
31striated muscle contraction (GO:0006941)4.53405536
32creatine metabolic process (GO:0006600)4.44810415
33regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.44022140
34tryptophan metabolic process (GO:0006568)4.40799183
352-oxoglutarate metabolic process (GO:0006103)4.37266834
36cellular ketone body metabolic process (GO:0046950)4.36863444
37bile acid biosynthetic process (GO:0006699)4.36794655
38estrogen biosynthetic process (GO:0006703)4.35805055
39protein carboxylation (GO:0018214)4.34568503
40peptidyl-glutamic acid carboxylation (GO:0017187)4.34568503
41plasma membrane repair (GO:0001778)4.32660465
42fatty acid beta-oxidation (GO:0006635)4.20869260
43urea metabolic process (GO:0019627)4.19270081
44urea cycle (GO:0000050)4.19270081
45negative regulation of fibrinolysis (GO:0051918)4.18893818
46amino-acid betaine metabolic process (GO:0006577)4.18008205
47regulation of triglyceride catabolic process (GO:0010896)4.17619928
48sulfur amino acid catabolic process (GO:0000098)4.17479726
49response to inactivity (GO:0014854)4.15412318
50myotube cell development (GO:0014904)4.14372108
51complement activation, alternative pathway (GO:0006957)4.14202625
52high-density lipoprotein particle remodeling (GO:0034375)4.12713916
53regulation of fibrinolysis (GO:0051917)4.05503310
54cysteine metabolic process (GO:0006534)4.04943222
55aspartate family amino acid catabolic process (GO:0009068)4.01307865
56triglyceride homeostasis (GO:0070328)4.01111056
57acylglycerol homeostasis (GO:0055090)4.01111056
58muscle contraction (GO:0006936)3.98131094
59homocysteine metabolic process (GO:0050667)3.97372279
60fatty acid transmembrane transport (GO:1902001)3.96781771
61fatty acid oxidation (GO:0019395)3.94551376
62serine family amino acid catabolic process (GO:0009071)3.93717559
63regulation of protein activation cascade (GO:2000257)3.93185115
64actomyosin structure organization (GO:0031032)3.89024237
65myoblast fusion (GO:0007520)3.88573362
66alpha-amino acid catabolic process (GO:1901606)3.87876760
67bile acid metabolic process (GO:0008206)3.87417347
68fatty acid catabolic process (GO:0009062)3.86785211
69nitrogen cycle metabolic process (GO:0071941)3.86386578
70carnitine shuttle (GO:0006853)3.86084154
71lipid oxidation (GO:0034440)3.85833960
72glycogen catabolic process (GO:0005980)3.84965110
73positive regulation of fatty acid beta-oxidation (GO:0032000)3.84798273
74tyrosine metabolic process (GO:0006570)3.83146025
75aromatic amino acid family metabolic process (GO:0009072)3.82926528
76short-chain fatty acid metabolic process (GO:0046459)3.81700295
77phospholipid homeostasis (GO:0055091)3.80939604
78negative regulation of protein localization to cell surface (GO:2000009)3.80621744
79regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.78698277
80ketone body metabolic process (GO:1902224)3.74307392
81monocarboxylic acid catabolic process (GO:0072329)3.73882090
82reverse cholesterol transport (GO:0043691)3.72976395
83acetyl-CoA metabolic process (GO:0006084)3.70960427
84valine metabolic process (GO:0006573)3.70844091
85muscle cell fate commitment (GO:0042693)3.66685419
86regulation of complement activation (GO:0030449)3.66267189
87cellular amino acid catabolic process (GO:0009063)3.62253475
88coenzyme catabolic process (GO:0009109)3.59872414
89plasma lipoprotein particle clearance (GO:0034381)3.59196754
90phospholipid efflux (GO:0033700)3.57687912
91protein-lipid complex remodeling (GO:0034368)3.56951668
92macromolecular complex remodeling (GO:0034367)3.56951668
93plasma lipoprotein particle remodeling (GO:0034369)3.56951668
94carnitine metabolic process (GO:0009437)3.54794282
95glucan catabolic process (GO:0009251)3.53800574
96muscle system process (GO:0003012)3.53323578
97cellular modified amino acid catabolic process (GO:0042219)3.50759613
984-hydroxyproline metabolic process (GO:0019471)3.48518910
99organic acid catabolic process (GO:0016054)3.47105973
100carboxylic acid catabolic process (GO:0046395)3.47105973
101dicarboxylic acid biosynthetic process (GO:0043650)3.46945931
102regulation of cholesterol esterification (GO:0010872)3.45678679
103cardiac muscle contraction (GO:0060048)3.45124303
104positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.42825844
105bile acid and bile salt transport (GO:0015721)3.42120792
106positive regulation of fatty acid oxidation (GO:0046321)3.41786158
107cellular polysaccharide catabolic process (GO:0044247)3.41127288
108ethanol oxidation (GO:0006069)3.40929508
109positive regulation of lipid catabolic process (GO:0050996)3.40827598
110skeletal muscle tissue regeneration (GO:0043403)3.39284355
111tricarboxylic acid metabolic process (GO:0072350)3.38534018
112regulation of sequestering of triglyceride (GO:0010889)3.37493228
113indolalkylamine metabolic process (GO:0006586)3.36005779
114glutamate metabolic process (GO:0006536)3.35912283
115benzene-containing compound metabolic process (GO:0042537)3.32643537
116syncytium formation by plasma membrane fusion (GO:0000768)3.32411031
117negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.32284496
118negative regulation of cholesterol transport (GO:0032375)3.31899858
119negative regulation of sterol transport (GO:0032372)3.31899858
120branched-chain amino acid catabolic process (GO:0009083)3.31324417
121regulation of cholesterol homeostasis (GO:2000188)3.31193899
122muscle fiber development (GO:0048747)3.30113394
123skeletal muscle tissue development (GO:0007519)3.28474032
124regulation of fatty acid beta-oxidation (GO:0031998)3.28019578
125negative regulation of lipase activity (GO:0060192)3.27349030
126regulation of fatty acid oxidation (GO:0046320)3.23335733
127branched-chain amino acid metabolic process (GO:0009081)3.21405572
128intestinal cholesterol absorption (GO:0030299)3.21390787
129regulation of cell communication by electrical coupling (GO:0010649)3.21030035
130oxaloacetate metabolic process (GO:0006107)3.17712015
131drug catabolic process (GO:0042737)3.16204770
132drug transmembrane transport (GO:0006855)3.15134246
133cellular glucuronidation (GO:0052695)3.14692741
134cholesterol homeostasis (GO:0042632)3.13340299
135skeletal muscle adaptation (GO:0043501)3.12440003
136fatty acid homeostasis (GO:0055089)3.12347678
137syncytium formation (GO:0006949)3.11549195
138cholesterol efflux (GO:0033344)3.09484359
139sterol homeostasis (GO:0055092)3.08951363
140regulation of bile acid biosynthetic process (GO:0070857)3.07554805
141tricarboxylic acid cycle (GO:0006099)3.06855473
142carnitine transmembrane transport (GO:1902603)3.06770175
143polysaccharide catabolic process (GO:0000272)3.03404710
144glucan biosynthetic process (GO:0009250)3.01399573
145glycogen biosynthetic process (GO:0005978)3.01399573
146cardiac muscle hypertrophy (GO:0003300)3.00932271
147regulation of actin filament-based movement (GO:1903115)3.00111008
148myotube differentiation (GO:0014902)2.99963401
149paraxial mesoderm development (GO:0048339)2.99667933
150muscle tissue morphogenesis (GO:0060415)2.96774217
151regulation of myoblast differentiation (GO:0045661)2.91112550
152striated muscle hypertrophy (GO:0014897)2.87179517
153response to follicle-stimulating hormone (GO:0032354)2.86954954
154muscle structure development (GO:0061061)2.85614813
155negative regulation of potassium ion transmembrane transport (GO:1901380)2.84686428
156muscle organ development (GO:0007517)2.80273152
157positive regulation of myoblast differentiation (GO:0045663)2.77763385
158muscle cell cellular homeostasis (GO:0046716)2.76612079
159regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.75739716
160cardiac muscle cell development (GO:0055013)2.73691491
161striated muscle cell development (GO:0055002)2.72214701
162lymph vessel development (GO:0001945)2.71847492
163striated muscle adaptation (GO:0014888)2.69428386
164cardiac muscle tissue morphogenesis (GO:0055008)2.67575900
165glycogen metabolic process (GO:0005977)2.67111790
166cardiac cell development (GO:0055006)2.63936565
167positive regulation of myotube differentiation (GO:0010831)2.62951632
168regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.61691487
169positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.61598731
170negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.61342422
171negative regulation of calcium ion transmembrane transport (GO:1903170)2.61342422
172regulation of striated muscle contraction (GO:0006942)2.61311673
173glucan metabolic process (GO:0044042)2.59207242
174cellular glucan metabolic process (GO:0006073)2.59207242
175glucocorticoid biosynthetic process (GO:0006704)2.59001392
176negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.58323091
177response to activity (GO:0014823)2.58025078
178relaxation of muscle (GO:0090075)2.57929877
179neuronal action potential propagation (GO:0019227)2.55674310
180adult heart development (GO:0007512)2.55658349
181regulation of lipoprotein metabolic process (GO:0050746)2.50684408
182regulation of calcium ion transmembrane transporter activity (GO:1901019)2.48430762
183regulation of calcium ion transmembrane transport (GO:1903169)2.48430762
184regulation of skeletal muscle fiber development (GO:0048742)2.46573381
185muscle organ morphogenesis (GO:0048644)2.44939661
186hippo signaling (GO:0035329)2.44363249
187regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.44262313
188muscle cell development (GO:0055001)2.41415530
189muscle hypertrophy (GO:0014896)2.38629996
190blood coagulation, intrinsic pathway (GO:0007597)2.38057633
191fructose metabolic process (GO:0006000)2.36208320
192regulation of protein localization to cell surface (GO:2000008)2.36099733
193regulation of transforming growth factor beta2 production (GO:0032909)2.34608452
194striated muscle tissue development (GO:0014706)2.33664747
195negative regulation of norepinephrine secretion (GO:0010700)2.32715422
196regulation of cAMP-dependent protein kinase activity (GO:2000479)2.31650157
197positive regulation of Rho protein signal transduction (GO:0035025)2.28440976
198regulation of muscle system process (GO:0090257)2.28050922
199muscle hypertrophy in response to stress (GO:0003299)2.27283270
200cardiac muscle adaptation (GO:0014887)2.27283270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.53135088
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.87897075
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.99163123
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.64689328
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.53526154
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.70443025
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.67968670
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.85445274
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.58534498
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.89392632
11EZH2_22144423_ChIP-Seq_EOC_Human2.76569319
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.72031932
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.66689615
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.54796544
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44501029
16GATA1_22025678_ChIP-Seq_K562_Human2.22608972
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.11126794
18CLOCK_20551151_ChIP-Seq_293T_Human2.07073913
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.03048465
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01665357
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84381010
22* FOXA2_19822575_ChIP-Seq_HepG2_Human1.76817015
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72604190
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67282079
25* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.64581695
26* TBX20_22080862_ChIP-Seq_HEART_Mouse1.64367508
27* TBX20_22328084_ChIP-Seq_HEART_Mouse1.64367508
28GBX2_23144817_ChIP-Seq_PC3_Human1.62817040
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60026345
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57290587
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56893655
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53034853
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52578981
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.52269490
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51927836
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50454957
37* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49757290
38* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49757290
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41769030
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39924632
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36397431
42ISL1_27105846_Chip-Seq_CPCs_Mouse1.35682845
43CJUN_26792858_Chip-Seq_BT549_Human1.35413857
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35352481
45AR_21572438_ChIP-Seq_LNCaP_Human1.33734538
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33428268
47* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31907515
48* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31144847
49* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30892414
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28948020
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28008238
52* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27950893
53SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26155550
54HNF4A_19822575_ChIP-Seq_HepG2_Human1.25752097
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25587694
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.24457660
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.23781908
58* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19837208
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.17446396
60* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16679154
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16074107
62* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15639862
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12493236
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11627823
65YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11490968
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.11045640
67ZNF263_19887448_ChIP-Seq_K562_Human1.10838749
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08361973
69HTT_18923047_ChIP-ChIP_STHdh_Human1.07087611
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.06679846
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.06009224
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05912664
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.05819371
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04689420
75SMAD4_21799915_ChIP-Seq_A2780_Human1.04384823
76TP53_18474530_ChIP-ChIP_U2OS_Human1.03915530
77* RNF2_27304074_Chip-Seq_ESCs_Mouse1.03898317
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02386982
79* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02362649
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.01915747
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01629295
82* EZH2_27294783_Chip-Seq_ESCs_Mouse0.99672597
83SMAD3_21741376_ChIP-Seq_HESCs_Human0.99426018
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99357425
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97960199
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.97857900
87SOX2_21211035_ChIP-Seq_LN229_Gbm0.96564581
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95887492
89* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95201837
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94533482
91* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94314841
92PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93396851
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93330755
94AHR_22903824_ChIP-Seq_MCF-7_Human0.93135318
95* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92857141
96GATA1_19941826_ChIP-Seq_K562_Human0.92256738
97* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92175953
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91936111
99* BRD4_25478319_ChIP-Seq_HGPS_Human0.91734712
100TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90394357
101TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90261185
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90084899
103* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89989713
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89550257
105GATA4_25053715_ChIP-Seq_YYC3_Human0.85729241
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85525194
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82352512
108FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81103296
109SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80976699
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80726451
111* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80352928
112LXR_22292898_ChIP-Seq_THP-1_Human0.79811785
113RXRA_24833708_ChIP-Seq_LIVER_Mouse0.78967475
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78605341
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75959957
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75959957
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.75896087
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74563671
119BCAT_22108803_ChIP-Seq_LS180_Human0.73834908
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.73641847
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.73603669
122AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72913266
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72553370
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.71674313
125MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.71648251
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71174994
127* GATA2_19941826_ChIP-Seq_K562_Human0.68193849
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.67642379
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64948715
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.62090728
131Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.60935123
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.60506874
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.60069026
134CTCF_27219007_Chip-Seq_Bcells_Human0.59716319
135GATA4_21415370_ChIP-Seq_HL-1_Mouse0.59540678
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.58711148
137RARA_24833708_ChIP-Seq_LIVER_Mouse0.58676605
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.57448460
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.57369553
140ERG_20517297_ChIP-Seq_VCAP_Human0.57261113
141OCT4_20526341_ChIP-Seq_ESCs_Human0.57060479
142GATA3_24758297_ChIP-Seq_MCF-7_Human0.56561753
143GATA6_25053715_ChIP-Seq_YYC3_Human0.55937541
144ESET_19884257_ChIP-Seq_ESCs_Mouse0.55551017
145* CBP_21632823_ChIP-Seq_H3396_Human0.54687720
146GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.54520448
147GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.54016281
148BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.53857902
149CEBPB_22108803_ChIP-Seq_LS180_Human0.53376519
150* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53271696
151NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.53221582
152NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.52828772
153SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52764553
154RAD21_21589869_ChIP-Seq_MESCs_Mouse0.52659672
155SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.52280899
156AR_20517297_ChIP-Seq_VCAP_Human0.52141589
157* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.51303482
158* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.51177130
159CDX2_22108803_ChIP-Seq_LS180_Human0.50625560
160PIAS1_25552417_ChIP-Seq_VCAP_Human0.50347531
161TP63_22573176_ChIP-Seq_HFKS_Human0.49864449
162CREB1_26743006_Chip-Seq_LNCaP_Human0.49404957
163IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.48643679
164SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48435400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.21227082
2MP0005360_urolithiasis5.37340581
3MP0005085_abnormal_gallbladder_physiolo5.07324938
4MP0005365_abnormal_bile_salt4.99794703
5MP0002837_dystrophic_cardiac_calcinosis4.23211910
6MP0008875_abnormal_xenobiotic_pharmacok3.69842002
7MP0003252_abnormal_bile_duct3.51322294
8MP0003195_calcinosis3.27907867
9MP0003806_abnormal_nucleotide_metabolis2.97285449
10MP0010329_abnormal_lipoprotein_level2.78511004
11MP0005083_abnormal_biliary_tract2.65106210
12MP0009840_abnormal_foam_cell2.58068474
13MP0008438_abnormal_cutaneous_collagen2.53751546
14MP0004272_abnormal_basement_membrane2.35397932
15MP0004084_abnormal_cardiac_muscle2.33293121
16MP0003646_muscle_fatigue2.30369745
17MP0004233_abnormal_muscle_weight2.28241574
18MP0005332_abnormal_amino_acid2.25881192
19MP0001666_abnormal_nutrient_absorption2.19340366
20MP0005670_abnormal_white_adipose2.15740410
21MP0002108_abnormal_muscle_morphology2.12801891
22MP0000733_abnormal_muscle_development2.02829337
23MP0004130_abnormal_muscle_cell1.96751671
24MP0002118_abnormal_lipid_homeostasis1.93115605
25MP0004036_abnormal_muscle_relaxation1.92303795
26MP0002332_abnormal_exercise_endurance1.89999465
27MP0003191_abnormal_cellular_cholesterol1.84746793
28MP0004215_abnormal_myocardial_fiber1.83816419
29MP0003941_abnormal_skin_development1.80655597
30MP0002138_abnormal_hepatobiliary_system1.80493288
31MP0000609_abnormal_liver_physiology1.79866451
32MP0005330_cardiomyopathy1.76566141
33MP0000751_myopathy1.71028895
34MP0003868_abnormal_feces_composition1.64744064
35MP0005319_abnormal_enzyme/_coenzyme1.63491353
36MP0001879_abnormal_lymphatic_vessel1.57952509
37MP0010368_abnormal_lymphatic_system1.49115053
38MP0003950_abnormal_plasma_membrane1.45203897
39MP0002078_abnormal_glucose_homeostasis1.44797137
40MP0004019_abnormal_vitamin_homeostasis1.44282537
41MP0000749_muscle_degeneration1.43492251
42MP0009643_abnormal_urine_homeostasis1.43357438
43MP0005666_abnormal_adipose_tissue1.43312690
44MP0010030_abnormal_orbit_morphology1.43278690
45MP0003122_maternal_imprinting1.39358102
46MP0004043_abnormal_pH_regulation1.39181837
47MP0006036_abnormal_mitochondrial_physio1.38769990
48MP0002972_abnormal_cardiac_muscle1.31466334
49MP0003385_abnormal_body_wall1.28727628
50MP0002269_muscular_atrophy1.27371453
51MP0008004_abnormal_stomach_pH1.27336985
52MP0003705_abnormal_hypodermis_morpholog1.27094218
53MP0004087_abnormal_muscle_fiber1.25989409
54MP0009780_abnormal_chondrocyte_physiolo1.22530605
55MP0005451_abnormal_body_composition1.22522505
56MP0005275_abnormal_skin_tensile1.21820855
57MP0008775_abnormal_heart_ventricle1.20643048
58MP0001544_abnormal_cardiovascular_syste1.17155406
59MP0005385_cardiovascular_system_phenoty1.17155406
60MP0005584_abnormal_enzyme/coenzyme_acti1.16706640
61MP0002909_abnormal_adrenal_gland1.16541620
62MP0005220_abnormal_exocrine_pancreas1.16383579
63MP0010630_abnormal_cardiac_muscle1.15413524
64MP0002693_abnormal_pancreas_physiology1.12948466
65MP0001299_abnormal_eye_distance/1.11808978
66MP0006138_congestive_heart_failure1.10718827
67MP0005620_abnormal_muscle_contractility1.08993317
68MP0001764_abnormal_homeostasis1.08896849
69MP0000534_abnormal_ureter_morphology1.08035961
70MP0006276_abnormal_autonomic_nervous1.08022896
71MP0002877_abnormal_melanocyte_morpholog1.07050344
72MP0001944_abnormal_pancreas_morphology1.06730950
73MP0009250_abnormal_appendicular_skeleto1.06167134
74MP0003566_abnormal_cell_adhesion1.05184177
75MP0002128_abnormal_blood_circulation1.02369186
76MP0005503_abnormal_tendon_morphology1.00189693
77MP0005464_abnormal_platelet_physiology1.00016474
78MP0003137_abnormal_impulse_conducting0.99857029
79MP0004270_analgesia0.98117106
80MP0003942_abnormal_urinary_system0.96894645
81MP0005375_adipose_tissue_phenotype0.96825154
82MP0005535_abnormal_body_temperature0.96273780
83MP0002971_abnormal_brown_adipose0.94139290
84MP0009697_abnormal_copulation0.94108427
85MP0005334_abnormal_fat_pad0.94071729
86MP0000598_abnormal_liver_morphology0.93505649
87MP0004185_abnormal_adipocyte_glucose0.93449721
88MP0002896_abnormal_bone_mineralization0.91720485
89MP0004085_abnormal_heartbeat0.90501173
90MP0001958_emphysema0.88317681
91MP0000230_abnormal_systemic_arterial0.88038114
92MP0000750_abnormal_muscle_regeneration0.87486162
93MP0005623_abnormal_meninges_morphology0.86138860
94MP0009642_abnormal_blood_homeostasis0.85103620
95MP0000266_abnormal_heart_morphology0.84857264
96MP0004134_abnormal_chest_morphology0.84632424
97MP0003279_aneurysm0.84443782
98MP0005636_abnormal_mineral_homeostasis0.83577910
99MP0000013_abnormal_adipose_tissue0.83459038
100MP0004510_myositis0.81804765
101MP0002106_abnormal_muscle_physiology0.81506922
102MP0002928_abnormal_bile_duct0.79466273
103MP0003221_abnormal_cardiomyocyte_apopto0.78538289
104MP0005171_absent_coat_pigmentation0.78132120
105MP0001756_abnormal_urination0.77534586
106MP0000747_muscle_weakness0.76773166
107MP0005266_abnormal_metabolism0.75395890
108MP0005647_abnormal_sex_gland0.74025705
109MP0003186_abnormal_redox_activity0.73709735
110MP0003953_abnormal_hormone_level0.73249565
111MP0009763_increased_sensitivity_to0.72561491
112MP0005448_abnormal_energy_balance0.71304371
113MP0000767_abnormal_smooth_muscle0.70144614
114MP0008961_abnormal_basal_metabolism0.69423656
115MP0003283_abnormal_digestive_organ0.67673810
116MP0006054_spinal_hemorrhage0.67474486
117MP0005409_darkened_coat_color0.67181871
118MP0003879_abnormal_hair_cell0.66861111
119MP0002697_abnormal_eye_size0.66846841
120MP0002127_abnormal_cardiovascular_syste0.66772098
121MP0003656_abnormal_erythrocyte_physiolo0.66510904
122MP0005369_muscle_phenotype0.66399262
123MP0001661_extended_life_span0.66300771
124MP0005084_abnormal_gallbladder_morpholo0.66290826
125MP0003828_pulmonary_edema0.64400395
126MP0000762_abnormal_tongue_morphology0.63388492
127MP0001765_abnormal_ion_homeostasis0.63155781
128MP0005167_abnormal_blood-brain_barrier0.63134498
129MP0000003_abnormal_adipose_tissue0.62352957
130MP0000759_abnormal_skeletal_muscle0.61925052
131MP0001915_intracranial_hemorrhage0.60657392
132MP0002114_abnormal_axial_skeleton0.60427448
133MP0004484_altered_response_of0.60284069
134MP0006035_abnormal_mitochondrial_morpho0.60122517
135MP0002233_abnormal_nose_morphology0.60001674
136MP0003935_abnormal_craniofacial_develop0.59257344
137MP0004145_abnormal_muscle_electrophysio0.58560239
138MP0002234_abnormal_pharynx_morphology0.57891300
139MP0001614_abnormal_blood_vessel0.57769915
140MP0008469_abnormal_protein_level0.56860053
141MP0005376_homeostasis/metabolism_phenot0.56051125
142MP0000428_abnormal_craniofacial_morphol0.55204567
143MP0000049_abnormal_middle_ear0.54902887
144MP0005187_abnormal_penis_morphology0.54888808
145MP0005165_increased_susceptibility_to0.54349644
146MP0009703_decreased_birth_body0.52301656
147MP0003300_gastrointestinal_ulcer0.52137674
148MP0005595_abnormal_vascular_smooth0.51777255
149MP0008789_abnormal_olfactory_epithelium0.50956240
150MP0001293_anophthalmia0.50837528
151MP0003091_abnormal_cell_migration0.50762985
152MP0003959_abnormal_lean_body0.49987797

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.17465078
2Nemaline bodies (HP:0003798)9.08853016
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.76949799
4Type 1 muscle fiber predominance (HP:0003803)7.27331399
5Hypoglycemic coma (HP:0001325)5.77249834
6Distal arthrogryposis (HP:0005684)5.53099838
7Abnormality of aromatic amino acid family metabolism (HP:0004338)5.47919861
8Intrahepatic cholestasis (HP:0001406)5.17480140
9Deep venous thrombosis (HP:0002625)5.16794897
10Ketosis (HP:0001946)4.88146199
11Ketoacidosis (HP:0001993)4.84904795
12Xanthomatosis (HP:0000991)4.81556409
13Round ear (HP:0100830)4.64281065
14Abnormality of monocarboxylic acid metabolism (HP:0010996)4.56145039
15Hyperinsulinemic hypoglycemia (HP:0000825)4.52569296
16Myopathic facies (HP:0002058)4.32492507
17Prolonged partial thromboplastin time (HP:0003645)4.30361012
18Ulnar deviation of the wrist (HP:0003049)4.26324951
19Hyperlipoproteinemia (HP:0010980)4.07093068
20Hypoglycemic seizures (HP:0002173)4.06306817
21EMG: myopathic abnormalities (HP:0003458)4.04775948
22Calcaneovalgus deformity (HP:0001848)3.98541166
23Hypobetalipoproteinemia (HP:0003563)3.97441035
24Hyperammonemia (HP:0001987)3.94986156
25Abnormality of the calf musculature (HP:0001430)3.92272875
26Abnormality of skeletal muscle fiber size (HP:0012084)3.85781997
27Rimmed vacuoles (HP:0003805)3.79167506
28Complement deficiency (HP:0004431)3.78540619
29Abnormality of fatty-acid metabolism (HP:0004359)3.72238261
30Hyperglycinuria (HP:0003108)3.66615516
31Hypoalphalipoproteinemia (HP:0003233)3.63554178
32Centrally nucleated skeletal muscle fibers (HP:0003687)3.62151345
33Neck muscle weakness (HP:0000467)3.57321315
34Hypolipoproteinemia (HP:0010981)3.54627478
35Abnormality of the common coagulation pathway (HP:0010990)3.53241626
36Sudden death (HP:0001699)3.52247364
37Deformed tarsal bones (HP:0008119)3.50195710
38Myoglobinuria (HP:0002913)3.49289736
39Abnormality of the intrinsic pathway (HP:0010989)3.47233145
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.44536402
41Epidermoid cyst (HP:0200040)3.43890556
42Hyperglycinemia (HP:0002154)3.43062487
43Hyperglycemia (HP:0003074)3.42718023
44Increased variability in muscle fiber diameter (HP:0003557)3.41685727
45Absent phalangeal crease (HP:0006109)3.41281412
46Abnormality of glycine metabolism (HP:0010895)3.38093799
47Abnormality of serine family amino acid metabolism (HP:0010894)3.38093799
48Difficulty running (HP:0009046)3.36764479
49Generalized aminoaciduria (HP:0002909)3.33953073
50Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.25966560
51Late onset (HP:0003584)3.23541048
52Ventricular tachycardia (HP:0004756)3.19547693
53Skin nodule (HP:0200036)3.14979008
54Myotonia (HP:0002486)3.12534715
55Increased connective tissue (HP:0009025)3.12170640
56Conjugated hyperbilirubinemia (HP:0002908)3.11948608
57Dicarboxylic aciduria (HP:0003215)3.11893194
58Abnormality of dicarboxylic acid metabolism (HP:0010995)3.11893194
59Joint hemorrhage (HP:0005261)3.10369165
60Symptomatic seizures (HP:0011145)3.02945475
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.99553238
62Distal lower limb muscle weakness (HP:0009053)2.99533316
63Right ventricular cardiomyopathy (HP:0011663)2.97124556
64Abnormality of sulfur amino acid metabolism (HP:0004339)2.90403873
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.89281138
66Pancreatic islet-cell hyperplasia (HP:0004510)2.88472220
67Gout (HP:0001997)2.83921434
68Fat malabsorption (HP:0002630)2.82098182
69Muscle stiffness (HP:0003552)2.82064182
70Abnormal finger flexion creases (HP:0006143)2.81370826
71Abnormality of endocrine pancreas physiology (HP:0012093)2.77415716
72Abnormality of the pancreatic islet cells (HP:0006476)2.77415716
73Malignant hyperthermia (HP:0002047)2.77306413
74Abnormality of methionine metabolism (HP:0010901)2.77200252
75Areflexia of lower limbs (HP:0002522)2.75007419
76Metabolic acidosis (HP:0001942)2.73324594
77Abnormality of purine metabolism (HP:0004352)2.73123589
78Asymmetric septal hypertrophy (HP:0001670)2.72998119
79Exercise-induced myalgia (HP:0003738)2.71003951
80Palpitations (HP:0001962)2.70600693
81Hyperbilirubinemia (HP:0002904)2.69991304
82Frequent falls (HP:0002359)2.69910881
83Abnormality of complement system (HP:0005339)2.69098486
84Spinal rigidity (HP:0003306)2.68754446
85Hypercholesterolemia (HP:0003124)2.67072270
86Abnormality of the calcaneus (HP:0008364)2.65302620
87Mildly elevated creatine phosphokinase (HP:0008180)2.64022686
88Calf muscle hypertrophy (HP:0008981)2.62474977
89Cerebral edema (HP:0002181)2.56814277
90Abnormality of nucleobase metabolism (HP:0010932)2.48409034
91Protrusio acetabuli (HP:0003179)2.47657855
92Exercise-induced muscle cramps (HP:0003710)2.45997802
93Lipoatrophy (HP:0100578)2.42089322
94Hip contracture (HP:0003273)2.41944020
95Scapular winging (HP:0003691)2.41410829
96EMG: neuropathic changes (HP:0003445)2.41334076
97Generalized muscle weakness (HP:0003324)2.40868079
98Hyporeflexia of lower limbs (HP:0002600)2.40794714
99Atrial fibrillation (HP:0005110)2.38702565
100Distal lower limb amyotrophy (HP:0008944)2.38195178
101Atrioventricular block (HP:0001678)2.38191668
102Insulin-resistant diabetes mellitus (HP:0000831)2.36885766
103Abnormality of serum amino acid levels (HP:0003112)2.35538986
104Abnormal gallbladder morphology (HP:0012437)2.34662440
105Rhabdomyolysis (HP:0003201)2.33239858
106Bundle branch block (HP:0011710)2.33021769
107Lethargy (HP:0001254)2.31013605
108Syncope (HP:0001279)2.29434694
109Slender build (HP:0001533)2.27397204
110Dilated cardiomyopathy (HP:0001644)2.26850174
111Delayed CNS myelination (HP:0002188)2.25484958
112Muscle hypertrophy of the lower extremities (HP:0008968)2.25219947
113Cholelithiasis (HP:0001081)2.24501527
114Menorrhagia (HP:0000132)2.23790347
115Gowers sign (HP:0003391)2.21901686
116Proximal tubulopathy (HP:0000114)2.20698866
117Hepatocellular carcinoma (HP:0001402)2.20502440
118Limited hip movement (HP:0008800)2.20339588
119Muscle fiber splitting (HP:0003555)2.19823729
120Myocardial infarction (HP:0001658)2.17744884
121Heart block (HP:0012722)2.16736457
122Aortic aneurysm (HP:0004942)2.16373978
123Primary atrial arrhythmia (HP:0001692)2.13969941
124Limb-girdle muscle atrophy (HP:0003797)2.12230989
125Fetal akinesia sequence (HP:0001989)2.09769693
126Hepatic necrosis (HP:0002605)2.06958948
127Renal cortical cysts (HP:0000803)2.06020900
128Vomiting (HP:0002013)2.04535135
129Glycosuria (HP:0003076)2.03435783
130Abnormality of urine glucose concentration (HP:0011016)2.03435783
131Subaortic stenosis (HP:0001682)2.03029533
132Abnormality of the left ventricular outflow tract (HP:0011103)2.03029533
133Weak cry (HP:0001612)2.02583775
134Abnormal atrioventricular conduction (HP:0005150)2.00848933
135Insulin resistance (HP:0000855)2.00730528
136Supraventricular tachycardia (HP:0004755)2.00494941
137Systemic lupus erythematosus (HP:0002725)2.00455677
138Abnormality of the ischium (HP:0003174)2.00020395
139Increased mean platelet volume (HP:0011877)1.99619790
140Abnormality of pyrimidine metabolism (HP:0004353)1.98979926
141Mitral stenosis (HP:0001718)1.97070769
142Supraventricular arrhythmia (HP:0005115)1.97048640
143Hyperuricemia (HP:0002149)1.96483686
144Increased purine levels (HP:0004368)1.96483686
145Large for gestational age (HP:0001520)1.96389572
146Pancreatitis (HP:0001733)1.93905684
147Back pain (HP:0003418)1.93693944
148Lower limb amyotrophy (HP:0007210)1.88675009
149Abnormality of the shoulder girdle musculature (HP:0001435)1.87907081
150Waddling gait (HP:0002515)1.86037491
151Bulbar palsy (HP:0001283)1.85881831
152Fatigable weakness (HP:0003473)1.85551168
153Abnormality of the neuromuscular junction (HP:0003398)1.85551168
154Difficulty climbing stairs (HP:0003551)1.85422618
155Aortic dissection (HP:0002647)1.84160023
156Popliteal pterygium (HP:0009756)1.81768292
157Premature rupture of membranes (HP:0001788)1.80007499
158Long clavicles (HP:0000890)1.79016926
159Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.78922830
160Muscular dystrophy (HP:0003560)1.78204840
161Hyperkalemia (HP:0002153)1.78067773
162Vascular tortuosity (HP:0004948)1.77536681
163Limb-girdle muscle weakness (HP:0003325)1.77107457
164Arterial tortuosity (HP:0005116)1.75850509
165Ulnar deviation of finger (HP:0009465)1.75178386
166Metatarsus adductus (HP:0001840)1.68880493
167Abnormality of the musculature of the pelvis (HP:0001469)1.68843707
168Abnormality of the hip-girdle musculature (HP:0001445)1.68843707
169Hypoplastic ischia (HP:0003175)1.66507418
170Proximal amyotrophy (HP:0007126)1.66400799
171Abnormality of the foot musculature (HP:0001436)1.65591652
172Hypoplasia of the iris (HP:0007676)1.63921699
173Abnormal platelet volume (HP:0011876)1.63305515
174Shoulder girdle muscle weakness (HP:0003547)1.63210752
175Foot dorsiflexor weakness (HP:0009027)1.55902718
176Pelvic girdle muscle weakness (HP:0003749)1.55159710
177Thin ribs (HP:0000883)1.48799369
178Adducted thumb (HP:0001181)1.47391684
179Breech presentation (HP:0001623)1.47040504
180Cerebral aneurysm (HP:0004944)1.46278233
181Prolonged bleeding time (HP:0003010)1.46190804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.95180833
2INSRR4.79726210
3ERN13.24476857
4TRIB33.15695854
5PKN22.97825682
6TTN2.97727419
7SIK12.87997468
8TAOK32.63931320
9FGFR42.31904225
10PDK42.17731391
11PDK32.17731391
12LATS22.15902604
13FLT32.11208053
14OBSCN1.91091430
15MYLK1.73273116
16TIE11.72571827
17PINK11.70657595
18PHKG21.68993339
19PHKG11.68993339
20MAPK151.62002125
21LATS11.59168966
22PTK61.54043238
23FRK1.49766000
24LMTK21.46185490
25WNK41.44038897
26AKT31.40428604
27NME11.40014755
28EPHB21.39835008
29PRKD31.29058575
30TGFBR21.28330158
31DDR21.26861514
32MARK11.25244229
33PIK3CA1.24588061
34PIK3CG1.23678535
35PRKAA21.20825556
36PDGFRA1.18073374
37NEK91.16687894
38PDK21.16363801
39PRKAA11.10266613
40STK38L1.08917909
41PAK31.07916394
42IRAK31.05112823
43MAP2K31.04789880
44EEF2K1.04355901
45TRPM71.03509427
46RIPK11.01743007
47EPHA30.96626424
48MAP3K30.95104219
49MAP3K70.94060492
50PRKD10.92278355
51MAPK110.91149162
52JAK10.90933316
53PASK0.90099664
54CAMK1D0.89431710
55MAP3K10.88279035
56JAK20.86195081
57DMPK0.86178961
58KDR0.85332037
59MAP2K40.83282661
60STK30.82560443
61NTRK10.80807737
62EPHB10.79925863
63MAP3K100.79855585
64ERBB40.79811537
65ERBB30.76594886
66TNIK0.76284524
67BMX0.75986177
68MST1R0.75286011
69MUSK0.73310399
70TYK20.73138543
71HIPK20.72858276
72CAMK2G0.71381730
73PTK2B0.69987330
74DYRK1B0.69686727
75AKT20.67190079
76CDC42BPA0.66033082
77CAMK1G0.65919210
78SGK30.65410157
79MAP3K50.64652367
80PRKACG0.64041524
81FGFR30.63011257
82GRK70.62730004
83MET0.61650240
84IRAK10.61025435
85PRKCH0.60363247
86MOS0.60103617
87ICK0.59279482
88PAK20.58550849
89CAMK40.58193606
90RET0.58130860
91MTOR0.56980243
92CAMK2D0.56877837
93PRKG10.56832278
94MAPK120.56068334
95STK390.55803183
96PDGFRB0.55409601
97PNCK0.53796159
98PTK20.53772909
99PLK20.53520218
100TBK10.53252753
101SGK20.50343583
102DAPK20.50316931
103STK240.47809155
104LIMK10.46058459
105PDPK10.45490268
106MAP3K20.45418159
107NEK10.43647159
108PKN10.43622000
109GSK3A0.43096649
110BRD40.43069681
111DAPK30.42949263
112KSR20.40754540
113TYRO30.40664841
114SGK2230.37523367
115SGK4940.37523367
116ILK0.37483498
117FER0.36296461
118ABL20.35520706
119WNK30.35029697
120EIF2AK10.34805306
121MAPKAPK30.34177780
122IGF1R0.33823774
123CAMK10.33354851
124CAMK2A0.33354005
125IRAK20.32625615
126RPS6KA20.32479388
127PDK10.31985466
128ROCK20.31378427
129PRKACB0.31365809
130PRKD20.31295339
131ERBB20.31020446
132FGFR20.30542857
133PRKACA0.30236723
134STK380.29726482
135ROCK10.29097838
136CAMK2B0.27824404
137SGK10.27515898
138FGFR10.26684780
139PRKCE0.26502117
140MARK20.26477005
141PRKCZ0.26415146
142RPS6KA30.25918234
143MAP2K10.25865333
144MAPK70.24792589
145RPS6KC10.24672041
146RPS6KL10.24672041
147MAPK100.22867746

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.60582054
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.43994965
3Fatty acid degradation_Homo sapiens_hsa000713.04424265
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.86874869
5Nitrogen metabolism_Homo sapiens_hsa009102.74325801
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73745000
7Tryptophan metabolism_Homo sapiens_hsa003802.73663779
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.66233456
9Propanoate metabolism_Homo sapiens_hsa006402.65472689
10Arginine biosynthesis_Homo sapiens_hsa002202.60729630
11ECM-receptor interaction_Homo sapiens_hsa045122.49907769
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49163817
13Butanoate metabolism_Homo sapiens_hsa006502.35954478
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.29844778
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.26485635
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23508850
17Fatty acid metabolism_Homo sapiens_hsa012122.22312487
18Complement and coagulation cascades_Homo sapiens_hsa046102.10632404
19PPAR signaling pathway_Homo sapiens_hsa033201.95025988
20Peroxisome_Homo sapiens_hsa041461.93246424
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89142600
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84344226
23Focal adhesion_Homo sapiens_hsa045101.78207083
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67899409
25Selenocompound metabolism_Homo sapiens_hsa004501.66711608
26beta-Alanine metabolism_Homo sapiens_hsa004101.64912048
27Sulfur metabolism_Homo sapiens_hsa009201.64245121
28Pyruvate metabolism_Homo sapiens_hsa006201.64208391
29Starch and sucrose metabolism_Homo sapiens_hsa005001.59238476
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55963765
31Phenylalanine metabolism_Homo sapiens_hsa003601.53515162
32Carbon metabolism_Homo sapiens_hsa012001.51392860
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49975233
34Histidine metabolism_Homo sapiens_hsa003401.47015784
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44449831
36Platelet activation_Homo sapiens_hsa046111.43567873
37Fatty acid elongation_Homo sapiens_hsa000621.40139322
38Chemical carcinogenesis_Homo sapiens_hsa052041.39286066
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36779926
40Adherens junction_Homo sapiens_hsa045201.36166007
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33724163
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.31663064
43Fat digestion and absorption_Homo sapiens_hsa049751.31370903
44Caffeine metabolism_Homo sapiens_hsa002321.31298282
45Staphylococcus aureus infection_Homo sapiens_hsa051501.28038176
46Tight junction_Homo sapiens_hsa045301.26622945
47Bile secretion_Homo sapiens_hsa049761.25499264
48ABC transporters_Homo sapiens_hsa020101.25438364
49Tyrosine metabolism_Homo sapiens_hsa003501.23541815
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.21544374
51Retinol metabolism_Homo sapiens_hsa008301.17907586
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.17649915
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16681975
54Lysine degradation_Homo sapiens_hsa003101.16545410
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15314202
56Oxytocin signaling pathway_Homo sapiens_hsa049211.14648466
57Biosynthesis of amino acids_Homo sapiens_hsa012301.10696821
58Calcium signaling pathway_Homo sapiens_hsa040201.05659927
59Hedgehog signaling pathway_Homo sapiens_hsa043401.03609880
60Arginine and proline metabolism_Homo sapiens_hsa003300.97670279
61Folate biosynthesis_Homo sapiens_hsa007900.95265987
62Amoebiasis_Homo sapiens_hsa051460.95209849
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.94780496
64Gap junction_Homo sapiens_hsa045400.92045984
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91778484
66Basal cell carcinoma_Homo sapiens_hsa052170.90697616
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86111894
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84377217
69Hippo signaling pathway_Homo sapiens_hsa043900.84312032
70Insulin resistance_Homo sapiens_hsa049310.83867334
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83294312
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81276917
73Renin secretion_Homo sapiens_hsa049240.80457015
74Proteoglycans in cancer_Homo sapiens_hsa052050.77704350
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75963981
76Axon guidance_Homo sapiens_hsa043600.75498128
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73528695
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73303973
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72394448
80Glycerolipid metabolism_Homo sapiens_hsa005610.70877875
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70061851
82Glucagon signaling pathway_Homo sapiens_hsa049220.67123587
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66845342
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65846932
85Vitamin digestion and absorption_Homo sapiens_hsa049770.65821904
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64953254
87Gastric acid secretion_Homo sapiens_hsa049710.64570245
88Melanogenesis_Homo sapiens_hsa049160.61443796
89Small cell lung cancer_Homo sapiens_hsa052220.61011633
90Endometrial cancer_Homo sapiens_hsa052130.60356329
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60316791
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.59393116
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59118562
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59004122
95Long-term depression_Homo sapiens_hsa047300.57771034
96Renal cell carcinoma_Homo sapiens_hsa052110.57625326
97TGF-beta signaling pathway_Homo sapiens_hsa043500.57077169
98Sulfur relay system_Homo sapiens_hsa041220.55665054
99FoxO signaling pathway_Homo sapiens_hsa040680.55357917
100Glioma_Homo sapiens_hsa052140.52961966
101Type II diabetes mellitus_Homo sapiens_hsa049300.52950130
102HIF-1 signaling pathway_Homo sapiens_hsa040660.52202137
103Dilated cardiomyopathy_Homo sapiens_hsa054140.51940553
104Galactose metabolism_Homo sapiens_hsa000520.51851554
105GnRH signaling pathway_Homo sapiens_hsa049120.50653010
106Wnt signaling pathway_Homo sapiens_hsa043100.50143497
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49252496
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49046710
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47954783
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.47623184
111mTOR signaling pathway_Homo sapiens_hsa041500.47564593
112Circadian entrainment_Homo sapiens_hsa047130.47142953
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45825171
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44461008
115Fatty acid biosynthesis_Homo sapiens_hsa000610.44449036
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44106901
117Thyroid cancer_Homo sapiens_hsa052160.43215180
118Long-term potentiation_Homo sapiens_hsa047200.43069299
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.42488113
120Metabolic pathways_Homo sapiens_hsa011000.41615981
121Cardiac muscle contraction_Homo sapiens_hsa042600.41289501
122Pathways in cancer_Homo sapiens_hsa052000.38843078
123Steroid biosynthesis_Homo sapiens_hsa001000.38224371
124Linoleic acid metabolism_Homo sapiens_hsa005910.37854757
125AMPK signaling pathway_Homo sapiens_hsa041520.37716389
126Choline metabolism in cancer_Homo sapiens_hsa052310.37442275
127Prion diseases_Homo sapiens_hsa050200.33941273
128Insulin signaling pathway_Homo sapiens_hsa049100.32977093
129Glutathione metabolism_Homo sapiens_hsa004800.32816873
130Fructose and mannose metabolism_Homo sapiens_hsa000510.31757711
131Pentose phosphate pathway_Homo sapiens_hsa000300.29214523
132Insulin secretion_Homo sapiens_hsa049110.27559378
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26974046
134Vitamin B6 metabolism_Homo sapiens_hsa007500.26328117
135Protein export_Homo sapiens_hsa030600.25838889
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21207219
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.20069114
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19011456
139One carbon pool by folate_Homo sapiens_hsa006700.15748479
140Ovarian steroidogenesis_Homo sapiens_hsa049130.14801365
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11446201
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.10448965
143Circadian rhythm_Homo sapiens_hsa047100.09401108
144Parkinsons disease_Homo sapiens_hsa050120.08860251
145Oxidative phosphorylation_Homo sapiens_hsa001900.08349523
146Alzheimers disease_Homo sapiens_hsa050100.08013888
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.02634129
148Protein digestion and absorption_Homo sapiens_hsa049740.01297966
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0127967

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