RHOBTB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RHOBTB3 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.35640531
2negative regulation of activin receptor signaling pathway (GO:0032926)5.01425023
3regulation of cardioblast differentiation (GO:0051890)4.78106012
4cell migration involved in gastrulation (GO:0042074)4.54304270
5embryonic foregut morphogenesis (GO:0048617)4.34484797
6anterior/posterior axis specification, embryo (GO:0008595)4.30909160
7regulation of mesoderm development (GO:2000380)4.29526010
8chondrocyte proliferation (GO:0035988)4.24274603
9regulation of transforming growth factor beta2 production (GO:0032909)4.14361282
10primitive streak formation (GO:0090009)4.07400415
11prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.07319446
12anterior/posterior axis specification (GO:0009948)4.03561787
13negative regulation of hormone biosynthetic process (GO:0032353)3.92594355
14pericardium development (GO:0060039)3.88386738
15axon ensheathment in central nervous system (GO:0032291)3.85002065
16central nervous system myelination (GO:0022010)3.85002065
17signal transduction involved in regulation of gene expression (GO:0023019)3.83977737
18phospholipid scrambling (GO:0017121)3.79988083
19limb bud formation (GO:0060174)3.74805920
20endoderm formation (GO:0001706)3.74145030
21bone trabecula formation (GO:0060346)3.71091493
22paraxial mesoderm development (GO:0048339)3.70463355
23lateral sprouting from an epithelium (GO:0060601)3.68263112
24extracellular regulation of signal transduction (GO:1900115)3.68257007
25extracellular negative regulation of signal transduction (GO:1900116)3.68257007
26somite rostral/caudal axis specification (GO:0032525)3.64579511
27outflow tract septum morphogenesis (GO:0003148)3.63594685
28regulation of glucocorticoid metabolic process (GO:0031943)3.60641721
29positive regulation of cardiac muscle cell proliferation (GO:0060045)3.57941804
30mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.57601830
31response to BMP (GO:0071772)3.53984964
32cellular response to BMP stimulus (GO:0071773)3.53984964
33branching involved in prostate gland morphogenesis (GO:0060442)3.47252374
34metanephric mesenchyme development (GO:0072075)3.44773996
35negative regulation of hormone metabolic process (GO:0032351)3.40550280
36regulation of activin receptor signaling pathway (GO:0032925)3.39509210
37mesenchymal cell proliferation (GO:0010463)3.39066298
38kidney mesenchyme development (GO:0072074)3.34346033
39negative regulation of axon extension involved in axon guidance (GO:0048843)3.33610504
40positive regulation of cardiac muscle tissue development (GO:0055025)3.29974040
41cerebral cortex radially oriented cell migration (GO:0021799)3.29803152
42myelination in peripheral nervous system (GO:0022011)3.24667311
43peripheral nervous system axon ensheathment (GO:0032292)3.24667311
44outer ear morphogenesis (GO:0042473)3.23586637
45regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.22352405
46positive regulation of cardiac muscle tissue growth (GO:0055023)3.20284998
47craniofacial suture morphogenesis (GO:0097094)3.16933916
48regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.14098954
49embryonic retina morphogenesis in camera-type eye (GO:0060059)3.13909486
50L-serine transport (GO:0015825)3.13110035
51hippo signaling (GO:0035329)3.12842831
52sequestering of extracellular ligand from receptor (GO:0035581)3.12788018
53regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.12343532
54cranial suture morphogenesis (GO:0060363)3.11025025
55regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.09703333
56embryonic axis specification (GO:0000578)3.04874761
57apical protein localization (GO:0045176)3.04726754
58cell proliferation involved in metanephros development (GO:0072203)3.03173205
59positive regulation of gastrulation (GO:2000543)3.01222818
60gastrulation (GO:0007369)3.00925750
61planar cell polarity pathway involved in neural tube closure (GO:0090179)2.98994903
62uterus development (GO:0060065)2.98985196
63atrioventricular valve morphogenesis (GO:0003181)2.97683683
64collagen fibril organization (GO:0030199)2.94361422
65proximal/distal pattern formation (GO:0009954)2.93985976
66nodal signaling pathway (GO:0038092)2.92468863
67camera-type eye morphogenesis (GO:0048593)2.91255486
68endocardial cushion development (GO:0003197)2.90790469
69axon ensheathment (GO:0008366)2.90138569
70ensheathment of neurons (GO:0007272)2.90138569
71dorsal/ventral axis specification (GO:0009950)2.89475147
72negative regulation of axon guidance (GO:1902668)2.88628843
73myelination (GO:0042552)2.87191844
74notochord development (GO:0030903)2.83498648
75mesenchyme morphogenesis (GO:0072132)2.83321531
76embryonic skeletal joint morphogenesis (GO:0060272)2.83017657
77axon extension involved in axon guidance (GO:0048846)2.81425219
78neuron projection extension involved in neuron projection guidance (GO:1902284)2.81425219
79astrocyte development (GO:0014002)2.80159526
80embryonic digit morphogenesis (GO:0042733)2.80125246
81regulation of mesenchymal cell proliferation (GO:0010464)2.79221488
82positive regulation of heart growth (GO:0060421)2.78143844
83mesenchyme development (GO:0060485)2.78008207
84chondrocyte development (GO:0002063)2.78003443
85cochlea morphogenesis (GO:0090103)2.77124447
86G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.76276737
87body morphogenesis (GO:0010171)2.74800480
88asymmetric protein localization (GO:0008105)2.74144872
89regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74085120
90SMAD protein signal transduction (GO:0060395)2.72966470
91ureteric bud development (GO:0001657)2.71557687
92regulation of gastrulation (GO:0010470)2.70135218
93regulation of cardiac muscle tissue development (GO:0055024)2.69934682
94insulin-like growth factor receptor signaling pathway (GO:0048009)2.69359748
95cell proliferation in forebrain (GO:0021846)2.68358950
96ventricular cardiac muscle cell development (GO:0055015)2.68290839
97positive regulation of muscle organ development (GO:0048636)2.68202557
98positive regulation of striated muscle tissue development (GO:0045844)2.68202557
99mesenchymal-epithelial cell signaling (GO:0060638)2.65962997
100cell proliferation involved in kidney development (GO:0072111)2.65874560
101dermatan sulfate biosynthetic process (GO:0030208)2.65679192
102artery development (GO:0060840)2.65492416
103positive regulation of muscle tissue development (GO:1901863)2.64392068
104Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.60840003
105positive regulation of mesenchymal cell proliferation (GO:0002053)2.60629578
106mesonephric tubule development (GO:0072164)2.60419720
107regulation of cardiac muscle cell proliferation (GO:0060043)2.60037617
108mesonephric epithelium development (GO:0072163)2.58881871
109negative regulation of DNA repair (GO:0045738)2.58561335
110embryonic cranial skeleton morphogenesis (GO:0048701)2.56927387
111embryonic forelimb morphogenesis (GO:0035115)2.55954048
112negative regulation of chondrocyte differentiation (GO:0032331)2.54867750
113positive regulation of osteoblast proliferation (GO:0033690)2.54602184
114negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.54360418
115negative chemotaxis (GO:0050919)2.54338595
116regulation of steroid hormone biosynthetic process (GO:0090030)2.53326382
117gastrulation with mouth forming second (GO:0001702)2.53011093
118regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.52791445
119midgut development (GO:0007494)2.52617610
120regulation of axon extension involved in axon guidance (GO:0048841)2.52577710
121embryonic pattern specification (GO:0009880)2.51898671
122negative regulation of smoothened signaling pathway (GO:0045879)2.51135448
123endocardial cushion morphogenesis (GO:0003203)2.50343071
124female gonad development (GO:0008585)2.49503966
125hindlimb morphogenesis (GO:0035137)2.49135116
126cardiac epithelial to mesenchymal transition (GO:0060317)2.48201529
127regulation of heart morphogenesis (GO:2000826)2.48146171
128negative regulation of embryonic development (GO:0045992)2.47468532
129branching involved in ureteric bud morphogenesis (GO:0001658)2.47416615
130regulation of establishment of planar polarity (GO:0090175)2.47336435
131COPI coating of Golgi vesicle (GO:0048205)2.46956730
132Golgi transport vesicle coating (GO:0048200)2.46956730
133regulation of non-canonical Wnt signaling pathway (GO:2000050)2.46167981
134regulation of transforming growth factor beta1 production (GO:0032908)2.45852842
135negative regulation of stem cell proliferation (GO:2000647)2.45537079
136regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.45202898
137neural crest cell development (GO:0014032)2.44746755
138retina vasculature morphogenesis in camera-type eye (GO:0061299)2.44461980
139substrate adhesion-dependent cell spreading (GO:0034446)2.44098552
140negative regulation of BMP signaling pathway (GO:0030514)2.43922691
141cranial nerve morphogenesis (GO:0021602)2.43395050
142positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.43312546
143positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.42520357
144response to follicle-stimulating hormone (GO:0032354)2.42011117
145organ formation (GO:0048645)2.41795921
146positive regulation of neuroblast proliferation (GO:0002052)2.41743491
147mesoderm formation (GO:0001707)2.40956740
148axis specification (GO:0009798)2.40339299
149DNA unwinding involved in DNA replication (GO:0006268)2.39468629
150establishment of nucleus localization (GO:0040023)2.38463154
151cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.38355915
152mitotic cytokinesis (GO:0000281)2.38022422
153somite development (GO:0061053)2.37266205
154nephron tubule formation (GO:0072079)2.35817782
155mesodermal cell differentiation (GO:0048333)2.35532425
156serine transport (GO:0032329)2.35439679
157forelimb morphogenesis (GO:0035136)2.35271130
158atrial septum morphogenesis (GO:0060413)2.34572882
159formation of primary germ layer (GO:0001704)2.33947646
160UDP-N-acetylglucosamine metabolic process (GO:0006047)2.33932019
161metanephros development (GO:0001656)2.33512575
162negative regulation of protein localization to cell surface (GO:2000009)2.33411254
163regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.33351649
164regulation of axon guidance (GO:1902667)2.33005199
165anatomical structure arrangement (GO:0048532)2.32674579
166photoreceptor cell differentiation (GO:0046530)2.30542778
167eye photoreceptor cell differentiation (GO:0001754)2.30542778
168genitalia morphogenesis (GO:0035112)2.30484883
169mesenchymal cell differentiation (GO:0048762)2.30197344
170regulation of cardiac muscle cell differentiation (GO:2000725)2.29780167
171myelin assembly (GO:0032288)2.29415375
172negative regulation of catenin import into nucleus (GO:0035414)2.29025511
173positive regulation of p38MAPK cascade (GO:1900745)2.28668646
174cardiac right ventricle morphogenesis (GO:0003215)2.28294654
175lens fiber cell development (GO:0070307)2.28159550
176dermatan sulfate metabolic process (GO:0030205)2.27981744
177axonal fasciculation (GO:0007413)2.27777519
178regulation of cellular senescence (GO:2000772)2.27345149
179regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.27060190
180cardiocyte differentiation (GO:0035051)2.25278061
181cell migration involved in heart development (GO:0060973)2.24960479
182mitotic sister chromatid cohesion (GO:0007064)2.23344356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.77231159
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.16524942
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.78177913
4* WT1_19549856_ChIP-ChIP_CCG9911_Human2.56908165
5* SMAD3_21741376_ChIP-Seq_HESCs_Human2.50116732
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43740795
7RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.35334918
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.31165054
9POU5F1_16153702_ChIP-ChIP_HESCs_Human2.24729584
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24676682
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.22267508
12EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.21799450
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.20336181
14PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.16144213
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.15990986
16FUS_26573619_Chip-Seq_HEK293_Human2.11643831
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.05909623
18* SMAD4_21741376_ChIP-Seq_HESCs_Human1.99926651
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95675218
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95675218
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95407022
22GBX2_23144817_ChIP-Seq_PC3_Human1.92722261
23* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89479339
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88176022
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86057559
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85574367
27EOMES_21245162_ChIP-Seq_HESCs_Human1.82477752
28EWS_26573619_Chip-Seq_HEK293_Human1.80915156
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77634551
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72559907
31* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70288566
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.68441579
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66730614
34SALL4_18804426_ChIP-ChIP_XEN_Mouse1.66101799
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65238391
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.63694053
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.63613353
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.63045570
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61649121
40ISL1_27105846_Chip-Seq_CPCs_Mouse1.58003655
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.55552191
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55118663
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52967862
44SOX2_16153702_ChIP-ChIP_HESCs_Human1.51353845
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50670025
46ZNF274_21170338_ChIP-Seq_K562_Hela1.50213759
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49537372
48E2F7_22180533_ChIP-Seq_HELA_Human1.49229397
49AR_21909140_ChIP-Seq_LNCAP_Human1.47874063
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.47636689
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.42179504
52* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41433681
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40959556
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38130990
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38130990
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38130990
57TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.36558123
58* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34762726
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32848982
60* SMAD3_21741376_ChIP-Seq_EPCs_Human1.32663318
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31679611
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31407057
63IGF1R_20145208_ChIP-Seq_DFB_Human1.30827790
64SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.30185611
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29436533
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28729030
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28729030
68* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28695994
69SOX9_26525672_Chip-Seq_HEART_Mouse1.28167458
70* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28012266
71* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27140318
72TP53_18474530_ChIP-ChIP_U2OS_Human1.26483162
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.26313559
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26070503
75* SMAD4_21741376_ChIP-Seq_EPCs_Human1.25234802
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25215424
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.24164951
78TBX3_20139965_ChIP-Seq_MESCs_Mouse1.24158234
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23109117
80TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23101590
81P300_19829295_ChIP-Seq_ESCs_Human1.22668211
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21836543
83FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21651389
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.20769183
85RNF2_27304074_Chip-Seq_NSC_Mouse1.19579069
86* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18574819
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18261471
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.16891240
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.16631079
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15880097
91* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14944165
92HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14028664
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12809860
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12449526
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12153439
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11330570
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11093594
98* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10765941
99* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10483701
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09521235
101* RING1B_27294783_Chip-Seq_ESCs_Mouse1.08882419
102CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08077668
103STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07800133
104BRD4_25478319_ChIP-Seq_HGPS_Human1.07553457
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07062674
106GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06862903
107TAF15_26573619_Chip-Seq_HEK293_Human1.06081795
108ER_23166858_ChIP-Seq_MCF-7_Human1.05669841
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05598560
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05576895
111CJUN_26792858_Chip-Seq_BT549_Human1.05116747
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02794821
113AR_25329375_ChIP-Seq_VCAP_Human1.02710253
114ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02529439
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02266966
116ESR1_21235772_ChIP-Seq_MCF-7_Human1.02214613
117AR_21572438_ChIP-Seq_LNCaP_Human1.01761740
118MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01585628
119FLI1_27457419_Chip-Seq_LIVER_Mouse1.00590633
120BCAT_22108803_ChIP-Seq_LS180_Human1.00162748
121TP53_16413492_ChIP-PET_HCT116_Human0.99968719
122ELK1_19687146_ChIP-ChIP_HELA_Human0.99338015
123FOXM1_23109430_ChIP-Seq_U2OS_Human0.99047907
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98921916
125YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98872022
126E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98758672
127CLOCK_20551151_ChIP-Seq_293T_Human0.97749148
128ARNT_22903824_ChIP-Seq_MCF-7_Human0.97490269
129EZH2_22144423_ChIP-Seq_EOC_Human0.97470554
130STAT3_23295773_ChIP-Seq_U87_Human0.97345321
131* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97198093
132SMAD4_21799915_ChIP-Seq_A2780_Human0.95991140
133POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93654965
134CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93455481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.47657947
2MP0010030_abnormal_orbit_morphology3.33803892
3MP0003123_paternal_imprinting3.07212784
4MP0000566_synostosis2.72827744
5MP0003385_abnormal_body_wall2.70689631
6MP0003122_maternal_imprinting2.66434070
7MP0005503_abnormal_tendon_morphology2.65427607
8MP0003121_genomic_imprinting2.49156659
9MP0000537_abnormal_urethra_morphology2.46838953
10MP0009250_abnormal_appendicular_skeleto2.46094261
11MP0009053_abnormal_anal_canal2.34440387
12MP0008004_abnormal_stomach_pH2.29873895
13MP0003937_abnormal_limbs/digits/tail_de2.29842826
14MP0003942_abnormal_urinary_system2.26534813
15MP0002938_white_spotting2.21667292
16MP0005623_abnormal_meninges_morphology2.10673237
17MP0004272_abnormal_basement_membrane2.09179009
18MP0005248_abnormal_Harderian_gland1.91659332
19MP0009384_cardiac_valve_regurgitation1.90302859
20MP0005257_abnormal_intraocular_pressure1.85730884
21MP0005171_absent_coat_pigmentation1.82770750
22MP0003755_abnormal_palate_morphology1.81386442
23MP0004134_abnormal_chest_morphology1.77049981
24MP0001299_abnormal_eye_distance/1.70949407
25MP0000428_abnormal_craniofacial_morphol1.70816364
26MP0000534_abnormal_ureter_morphology1.67392680
27MP0000049_abnormal_middle_ear1.66208055
28MP0003115_abnormal_respiratory_system1.63075047
29MP0009780_abnormal_chondrocyte_physiolo1.63058143
30MP0002249_abnormal_larynx_morphology1.60423800
31MP0003787_abnormal_imprinting1.59932783
32MP0002282_abnormal_trachea_morphology1.59053959
33MP0002932_abnormal_joint_morphology1.58699943
34MP0003941_abnormal_skin_development1.58086138
35MP0005275_abnormal_skin_tensile1.51893743
36MP0003705_abnormal_hypodermis_morpholog1.49776163
37MP0000778_abnormal_nervous_system1.43795651
38MP0003935_abnormal_craniofacial_develop1.42119919
39MP0003279_aneurysm1.40801715
40MP0002233_abnormal_nose_morphology1.39978660
41MP0000733_abnormal_muscle_development1.39861068
42MP0010368_abnormal_lymphatic_system1.38202385
43MP0002102_abnormal_ear_morphology1.37813825
44MP0005508_abnormal_skeleton_morphology1.37168114
45MP0003315_abnormal_perineum_morphology1.33597148
46MP0002127_abnormal_cardiovascular_syste1.31888637
47MP0002108_abnormal_muscle_morphology1.31593860
48MP0003938_abnormal_ear_development1.29793895
49MP0003566_abnormal_cell_adhesion1.29153329
50MP0002116_abnormal_craniofacial_bone1.28166825
51MP0003119_abnormal_digestive_system1.27341172
52MP0004215_abnormal_myocardial_fiber1.27156602
53MP0001293_anophthalmia1.25915022
54MP0001672_abnormal_embryogenesis/_devel1.25896750
55MP0005380_embryogenesis_phenotype1.25896750
56MP0004133_heterotaxia1.23845080
57MP0003950_abnormal_plasma_membrane1.22857820
58MP0003283_abnormal_digestive_organ1.22839287
59MP0002109_abnormal_limb_morphology1.22787747
60MP0001177_atelectasis1.20118594
61MP0000762_abnormal_tongue_morphology1.16697297
62MP0000432_abnormal_head_morphology1.15222699
63MP0002114_abnormal_axial_skeleton1.13632918
64MP0003984_embryonic_growth_retardation1.13561623
65MP0009697_abnormal_copulation1.13530549
66MP0002088_abnormal_embryonic_growth/wei1.13114933
67MP0004197_abnormal_fetal_growth/weight/1.12646981
68MP0004084_abnormal_cardiac_muscle1.12484192
69MP0002697_abnormal_eye_size1.10335956
70MP0005187_abnormal_penis_morphology1.10128288
71MP0002177_abnormal_outer_ear1.07585311
72MP0003890_abnormal_embryonic-extraembry1.07284153
73MP0006054_spinal_hemorrhage1.07103947
74MP0003861_abnormal_nervous_system1.05957732
75MP0000163_abnormal_cartilage_morphology1.04008010
76MP0002115_abnormal_skeleton_extremities1.03636491
77MP0002111_abnormal_tail_morphology1.02151390
78MP0004145_abnormal_muscle_electrophysio1.00431687
79MP0001340_abnormal_eyelid_morphology1.00276105
80MP0000516_abnormal_urinary_system1.00005803
81MP0005367_renal/urinary_system_phenotyp1.00005803
82MP0001286_abnormal_eye_development0.97154099
83MP0010352_gastrointestinal_tract_polyps0.97030813
84MP0000631_abnormal_neuroendocrine_gland0.96913990
85MP0008789_abnormal_olfactory_epithelium0.96861321
86MP0001661_extended_life_span0.96579222
87MP0004085_abnormal_heartbeat0.95505942
88MP0000920_abnormal_myelination0.95074970
89MP0005499_abnormal_olfactory_system0.94789462
90MP0005394_taste/olfaction_phenotype0.94789462
91MP0000639_abnormal_adrenal_gland0.94762575
92MP0002086_abnormal_extraembryonic_tissu0.93744194
93MP0000462_abnormal_digestive_system0.93703588
94MP0000767_abnormal_smooth_muscle0.93654865
95MP0005330_cardiomyopathy0.93422078
96MP0002085_abnormal_embryonic_tissue0.93100544
97MP0002751_abnormal_autonomic_nervous0.92915441
98MP0002084_abnormal_developmental_patter0.90863685
99MP0008775_abnormal_heart_ventricle0.90456877
100MP0001346_abnormal_lacrimal_gland0.89157597
101MP0000749_muscle_degeneration0.88440222
102MP0001958_emphysema0.87848786
103MP0002896_abnormal_bone_mineralization0.87118396
104MP0008932_abnormal_embryonic_tissue0.85982827
105MP0003936_abnormal_reproductive_system0.85960970
106MP0002081_perinatal_lethality0.83853056
107MP0002234_abnormal_pharynx_morphology0.83717352
108MP0001984_abnormal_olfaction0.83686859
109MP0001697_abnormal_embryo_size0.83634362
110MP0002877_abnormal_melanocyte_morpholog0.83092534
111MP0004233_abnormal_muscle_weight0.83088086
112MP0002092_abnormal_eye_morphology0.82386152
113MP0009703_decreased_birth_body0.82054226
114MP0002163_abnormal_gland_morphology0.81649281
115MP0005076_abnormal_cell_differentiation0.80814977
116MP0003943_abnormal_hepatobiliary_system0.80606094
117MP0006292_abnormal_olfactory_placode0.77429724
118MP0003137_abnormal_impulse_conducting0.76752359
119MP0004957_abnormal_blastocyst_morpholog0.75833022
120MP0002113_abnormal_skeleton_development0.75327504
121MP0002295_abnormal_pulmonary_circulatio0.74538383
122MP0000266_abnormal_heart_morphology0.74403879
123MP0002128_abnormal_blood_circulation0.73753707
124MP0004885_abnormal_endolymph0.73611464
125MP0001529_abnormal_vocalization0.72593468
126MP0006138_congestive_heart_failure0.72076370
127MP0001879_abnormal_lymphatic_vessel0.71420524
128MP0006072_abnormal_retinal_apoptosis0.70943167
129MP0005408_hypopigmentation0.68821084
130MP0002925_abnormal_cardiovascular_devel0.68129981
131MP0002089_abnormal_postnatal_growth/wei0.66930004
132MP0001485_abnormal_pinna_reflex0.66458540
133MP0000751_myopathy0.66454921
134MP0005197_abnormal_uvea_morphology0.66197576
135MP0009672_abnormal_birth_weight0.66185165
136MP0003634_abnormal_glial_cell0.65864802
137MP0000647_abnormal_sebaceous_gland0.65794087
138MP0002152_abnormal_brain_morphology0.65102749
139MP0003567_abnormal_fetal_cardiomyocyte0.63431159

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)4.68562830
2Abnormal pancreas size (HP:0012094)4.30390335
3Double outlet right ventricle (HP:0001719)4.13122179
4Congenital malformation of the right heart (HP:0011723)4.13122179
5Short 4th metacarpal (HP:0010044)3.77535235
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.77535235
7Abnormality of the 4th metacarpal (HP:0010012)3.27881866
8Shallow orbits (HP:0000586)3.21541538
9Abnormality of the umbilical cord (HP:0010881)3.07440934
10Premature rupture of membranes (HP:0001788)3.02739160
11Diastasis recti (HP:0001540)3.01005919
12Protrusio acetabuli (HP:0003179)2.90756567
13Coronal craniosynostosis (HP:0004440)2.77408630
14Microglossia (HP:0000171)2.62669845
15Abnormality of the distal phalanx of the thumb (HP:0009617)2.61291390
16Transposition of the great arteries (HP:0001669)2.60800506
17Abnormal connection of the cardiac segments (HP:0011545)2.60800506
18Abnormal ventriculo-arterial connection (HP:0011563)2.60800506
19Abnormality of dentin (HP:0010299)2.55728580
20Midline defect of the nose (HP:0004122)2.54930748
21Overgrowth (HP:0001548)2.54465449
22Buphthalmos (HP:0000557)2.51583850
23Abnormality of the phalanges of the hallux (HP:0010057)2.51408634
24Anal stenosis (HP:0002025)2.46609883
25Short humerus (HP:0005792)2.42644752
26Spinal cord lesions (HP:0100561)2.41482462
27Syringomyelia (HP:0003396)2.41482462
28Soft skin (HP:0000977)2.38218912
29Morphological abnormality of the middle ear (HP:0008609)2.37361401
30Renal duplication (HP:0000075)2.32696099
31Aplasia/hypoplasia of the humerus (HP:0006507)2.27122925
32Preauricular pit (HP:0004467)2.26344220
33Periauricular skin pits (HP:0100277)2.26344220
34Bell-shaped thorax (HP:0001591)2.23695392
35Cutaneous finger syndactyly (HP:0010554)2.19926665
36Intestinal atresia (HP:0011100)2.19510829
37Ankyloglossia (HP:0010296)2.18883326
38Broad thumb (HP:0011304)2.17317396
39Pulmonic stenosis (HP:0001642)2.16734463
40Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.16042308
41Mesomelia (HP:0003027)2.14805605
42Aortic dissection (HP:0002647)2.14550589
43Bowel diverticulosis (HP:0005222)2.12556154
44Fragile skin (HP:0001030)2.12406609
45Embryonal renal neoplasm (HP:0011794)2.11978390
46Asymmetry of the thorax (HP:0001555)2.11380863
47Broad toe (HP:0001837)2.09383087
48Abnormality of the parietal bone (HP:0002696)2.09349445
49Nephroblastoma (Wilms tumor) (HP:0002667)2.08851611
50Abdominal situs inversus (HP:0003363)2.08248468
51Abnormality of abdominal situs (HP:0011620)2.08248468
52Hypoalphalipoproteinemia (HP:0003233)2.07755900
53Myelomeningocele (HP:0002475)2.07078075
54Alacrima (HP:0000522)2.07007276
55Termporal pattern (HP:0011008)2.05436266
56Insidious onset (HP:0003587)2.05436266
57Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05317936
58Broad metatarsal (HP:0001783)2.05090425
59Broad long bones (HP:0005622)2.03594500
60Adrenal hypoplasia (HP:0000835)2.02802240
61Missing ribs (HP:0000921)2.02544261
62Mitral valve prolapse (HP:0001634)2.01632568
63Neonatal short-limb short stature (HP:0008921)2.00329742
64Bladder diverticulum (HP:0000015)1.99749225
65Cutaneous syndactyly (HP:0012725)1.99529581
66Abnormal umbilical cord blood vessels (HP:0011403)1.98576069
67Single umbilical artery (HP:0001195)1.98576069
68Abnormality of the fetal cardiovascular system (HP:0010948)1.98576069
69Shawl scrotum (HP:0000049)1.98198912
70Abnormalities of placenta or umbilical cord (HP:0001194)1.97291835
71Gonadotropin excess (HP:0000837)1.97163705
72Aortic aneurysm (HP:0004942)1.96935364
73Short middle phalanx of the 5th finger (HP:0004220)1.96914485
74Neoplasm of the adrenal cortex (HP:0100641)1.96912379
75Abnormality of the 2nd finger (HP:0004100)1.96771858
76Broad phalanx (HP:0006009)1.94700555
77Broad ribs (HP:0000885)1.94024388
78Ectopic anus (HP:0004397)1.93301066
79Knee flexion contracture (HP:0006380)1.91008267
80Broad finger (HP:0001500)1.90723725
81Hypoplastic pelvis (HP:0008839)1.90527089
82Patent foramen ovale (HP:0001655)1.90257637
83Vascular tortuosity (HP:0004948)1.89216974
84Broad phalanges of the hand (HP:0009768)1.88605264
85Preaxial foot polydactyly (HP:0001841)1.88037755
86Abnormality of the nasolacrimal system (HP:0000614)1.86586166
87Abnormality of the calf musculature (HP:0001430)1.85420807
88Gonadal dysgenesis (HP:0000133)1.85080527
89Germ cell neoplasia (HP:0100728)1.84697774
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.84298581
91Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.84201108
92Volvulus (HP:0002580)1.84173161
93Aplasia involving bones of the upper limbs (HP:0009823)1.84092790
94Aplasia of the phalanges of the hand (HP:0009802)1.84092790
95Aplasia involving bones of the extremities (HP:0009825)1.84092790
96Arterial tortuosity (HP:0005116)1.83238804
97Abnormality of the parathyroid morphology (HP:0011766)1.82559923
98Omphalocele (HP:0001539)1.81294550
99Wide anterior fontanel (HP:0000260)1.80998431
100Anophthalmia (HP:0000528)1.78781235
101Short tibia (HP:0005736)1.78738942
102Atrophic scars (HP:0001075)1.77627324
103Infantile muscular hypotonia (HP:0008947)1.77299085
104Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76951183
105Bifid tongue (HP:0010297)1.75767710
106Wormian bones (HP:0002645)1.75107944
107Abnormal lung lobation (HP:0002101)1.75089216
108Aplasia/Hypoplasia of the tibia (HP:0005772)1.75018383
109Abnormality of incisor morphology (HP:0011063)1.73675355
110Abnormality of the pubic bones (HP:0003172)1.73505811
111Broad distal phalanx of finger (HP:0009836)1.73282754
112Deviation of the hallux (HP:0010051)1.72969902
113Dilatation of the ascending aorta (HP:0005111)1.71864971
114Limited hip movement (HP:0008800)1.71146255
115Spinal rigidity (HP:0003306)1.70770756
116Abnormality of the phalanges of the 5th finger (HP:0004213)1.70457084
117Absent radius (HP:0003974)1.70319962
118Short 5th finger (HP:0009237)1.69830444
119Right ventricular cardiomyopathy (HP:0011663)1.68275988
120Abnormal vertebral ossification (HP:0100569)1.68185425
121Ankle contracture (HP:0006466)1.66382847
122Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.65229181
123Abnormality of the ischium (HP:0003174)1.64021591
124Abnormality of the middle phalanges of the toes (HP:0010183)1.63799838
125Abnormality of the lacrimal duct (HP:0011481)1.63672650
126Hypoplastic left heart (HP:0004383)1.63196522
127Type 1 muscle fiber predominance (HP:0003803)1.63049306
128Scapular winging (HP:0003691)1.62842291
129Cortical dysplasia (HP:0002539)1.62574613
130Abnormality of oral frenula (HP:0000190)1.61511202
131Decreased lacrimation (HP:0000633)1.58722243
132Bilateral microphthalmos (HP:0007633)1.58364683
133Degeneration of the lateral corticospinal tracts (HP:0002314)1.58346006
134Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.58346006
135Megalencephaly (HP:0001355)1.57267514
136Short hallux (HP:0010109)1.57099842
137Trigonocephaly (HP:0000243)1.55668499
138Aplasia involving forearm bones (HP:0009822)1.55593209
139Absent forearm bone (HP:0003953)1.55593209
140Mild short stature (HP:0003502)1.55257647
141Hyperglycemia (HP:0003074)1.53844768
142Abnormality of the nasal septum (HP:0000419)1.53801063
143Hallux valgus (HP:0001822)1.53508748
144Intellectual disability, moderate (HP:0002342)1.53360813
145Abnormality of the aortic arch (HP:0012303)1.52432707
146Hypoplastic ischia (HP:0003175)1.52155338
147Colon cancer (HP:0003003)1.52039159
148Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.51505996
149Testicular neoplasm (HP:0010788)1.50867038
150Renal dysplasia (HP:0000110)1.50827064
151Natal tooth (HP:0000695)1.50450194
152Hyperextensible skin (HP:0000974)1.50245211
153Limb-girdle muscle weakness (HP:0003325)1.49963551
154Renal hypoplasia (HP:0000089)1.49775275
155Aqueductal stenosis (HP:0002410)1.49750905
156Increased number of teeth (HP:0011069)1.49515196
157Abnormal auditory evoked potentials (HP:0006958)1.49063107
158Blue sclerae (HP:0000592)1.48490678
159Septo-optic dysplasia (HP:0100842)1.47854223
160Deviation of the thumb (HP:0009603)1.46363527
161Tracheal stenosis (HP:0002777)1.46131243
162Ulnar deviation of finger (HP:0009465)1.45720374
163Abnormal delivery (HP:0001787)1.45340887
164Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.43923654
165Skin pits (HP:0100276)1.43078164
166Abnormality of pain sensation (HP:0010832)1.39316277
167Impaired pain sensation (HP:0007328)1.39316277
168Increased nuchal translucency (HP:0010880)1.38791886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.52801658
2LATS13.27464165
3FGFR22.63363578
4TRIM282.63060399
5MKNK12.62887647
6ERBB32.62537396
7STK392.50237013
8TNIK2.41566886
9DDR22.40844648
10FLT32.23905789
11FRK2.23343926
12AKT32.18545738
13WEE12.15414725
14PNCK2.15284490
15LIMK12.07869622
16PDGFRA2.03183877
17PLK42.03109417
18BCR1.95292809
19MET1.75373562
20NEK11.71452944
21EPHB21.71065406
22TTN1.69590917
23CDC71.66076579
24PRKD31.63584198
25MST41.62109382
26ZAK1.61861212
27MYLK1.61433529
28MKNK21.58694575
29NUAK11.57689627
30PAK31.48148421
31KSR11.43804458
32FGFR11.39570618
33LATS21.38983671
34CSNK1A1L1.34654489
35SCYL21.33835977
36STK31.33495341
37EIF2AK31.33404192
38EIF2AK11.32640772
39PASK1.29604274
40BRSK21.28204991
41PKN11.28024756
42STK38L1.26963120
43FER1.26714332
44PLK31.26353386
45PDK21.24926321
46CSNK1G31.21803900
47TYRO31.20849800
48MAP3K121.19583768
49WNK11.19162550
50MELK1.17280529
51SRPK11.17137871
52MAPK131.15392699
53CASK1.14715531
54PLK21.11874911
55MARK11.10846380
56UHMK11.09321588
57WNK31.08240208
58PAK21.06812705
59ROCK21.05830209
60PBK1.05205056
61SIK31.04647925
62ICK1.02527500
63WNK41.01944017
64ROCK10.98862510
65CSNK1G10.98820886
66NEK90.97193531
67TGFBR10.93185983
68STK100.92016108
69NEK20.91368487
70CSNK1G20.90696707
71CHEK20.87478627
72TRPM70.83825156
73PTK60.83371485
74EPHA40.83294508
75ILK0.80709255
76PDGFRB0.79166072
77MAP2K10.77905291
78OXSR10.77440743
79SGK2230.77126828
80SGK4940.77126828
81CLK10.77022919
82PAK60.74116109
83EIF2AK20.72978878
84BRSK10.72832665
85OBSCN0.70808360
86PIK3CA0.69974753
87BMPR1B0.68227124
88TSSK60.66364883
89NTRK10.65773390
90BRD40.65199442
91CDK140.64921594
92PRPF4B0.64511915
93PTK20.63535493
94DYRK20.62443250
95MAP3K40.60867122
96CDK180.59666323
97TRIB30.58831708
98CDK150.57235268
99CDK10.56274422
100SIK10.55445833
101MAP3K90.52730914
102TTK0.51887562
103MUSK0.51875479
104NTRK30.50725266
105ACVR1B0.50084233
106NEK60.49481539
107DMPK0.49130664
108ERBB40.49068913
109PAK40.48670824
110YES10.48653429
111LRRK20.48264803
112CHEK10.48011314
113CDK80.47690840
114CAMK2D0.47594564
115CDK11A0.47104528
116EPHA20.47036123
117ERBB20.46799270
118TESK10.45380347
119CAMK2B0.44505106
120PHKG10.44058846
121PHKG20.44058846
122RAF10.43182269
123PLK10.43147512
124CAMK1G0.42938210
125MTOR0.41363270
126PRKD10.40624538
127MAP3K20.39523556
128PRKCH0.39378001
129MAP3K80.38619072
130RET0.36925221
131PRKCE0.36835420
132TAF10.36462241
133BRAF0.36420044
134STK380.36162864
135CSNK1D0.36032138
136PRKDC0.35503421
137MINK10.35481753
138ADRBK10.34796653
139MAPK100.34743107
140TGFBR20.29851488
141ATM0.28218772

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.93019820
2Hedgehog signaling pathway_Homo sapiens_hsa043402.87078688
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.63929896
4Hippo signaling pathway_Homo sapiens_hsa043902.58040899
5Axon guidance_Homo sapiens_hsa043602.32708775
6ECM-receptor interaction_Homo sapiens_hsa045122.12595639
7Cell cycle_Homo sapiens_hsa041102.12227270
8TGF-beta signaling pathway_Homo sapiens_hsa043502.03042206
9Tight junction_Homo sapiens_hsa045301.97389725
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.96526568
11Propanoate metabolism_Homo sapiens_hsa006401.91698695
12MicroRNAs in cancer_Homo sapiens_hsa052061.91599245
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90719902
14Adherens junction_Homo sapiens_hsa045201.88302584
15Focal adhesion_Homo sapiens_hsa045101.85673555
16Pyruvate metabolism_Homo sapiens_hsa006201.84104827
17Steroid biosynthesis_Homo sapiens_hsa001001.69381442
18Wnt signaling pathway_Homo sapiens_hsa043101.67926077
19Dilated cardiomyopathy_Homo sapiens_hsa054141.63360807
20Proteoglycans in cancer_Homo sapiens_hsa052051.60542629
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.58451720
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.55377974
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.54502568
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52369848
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44215420
26Prostate cancer_Homo sapiens_hsa052151.42615527
27Alcoholism_Homo sapiens_hsa050341.42314253
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40561021
29mRNA surveillance pathway_Homo sapiens_hsa030151.38651294
30Melanogenesis_Homo sapiens_hsa049161.34911130
31Oocyte meiosis_Homo sapiens_hsa041141.33821778
32Melanoma_Homo sapiens_hsa052181.33235726
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32168642
34Fatty acid metabolism_Homo sapiens_hsa012121.28121333
35Endometrial cancer_Homo sapiens_hsa052131.23895394
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23114519
37Systemic lupus erythematosus_Homo sapiens_hsa053221.22835122
38Sulfur metabolism_Homo sapiens_hsa009201.22341627
39Glioma_Homo sapiens_hsa052141.21813601
40Renal cell carcinoma_Homo sapiens_hsa052111.20604175
41Gap junction_Homo sapiens_hsa045401.19170387
42Protein export_Homo sapiens_hsa030601.17622573
43Colorectal cancer_Homo sapiens_hsa052101.16609196
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.14524439
45Long-term depression_Homo sapiens_hsa047301.12499509
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11724520
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11312741
48Spliceosome_Homo sapiens_hsa030401.11228226
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09208403
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08722501
51Small cell lung cancer_Homo sapiens_hsa052221.07863149
52Pathways in cancer_Homo sapiens_hsa052001.06433624
53Protein digestion and absorption_Homo sapiens_hsa049741.02450082
54RNA degradation_Homo sapiens_hsa030181.02433099
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01583741
56Vitamin B6 metabolism_Homo sapiens_hsa007500.97884642
57RNA transport_Homo sapiens_hsa030130.97014927
58Butanoate metabolism_Homo sapiens_hsa006500.92822334
59Rap1 signaling pathway_Homo sapiens_hsa040150.90533705
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89386092
61Bladder cancer_Homo sapiens_hsa052190.88818164
62ErbB signaling pathway_Homo sapiens_hsa040120.86759436
63Chronic myeloid leukemia_Homo sapiens_hsa052200.86078519
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85333174
65Ether lipid metabolism_Homo sapiens_hsa005650.83130735
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80472396
67Fatty acid elongation_Homo sapiens_hsa000620.79038756
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78731161
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78229035
70Notch signaling pathway_Homo sapiens_hsa043300.78161126
71Viral myocarditis_Homo sapiens_hsa054160.75975982
72Fanconi anemia pathway_Homo sapiens_hsa034600.75507028
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71838735
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71035001
75Ovarian steroidogenesis_Homo sapiens_hsa049130.69660190
76Lysine degradation_Homo sapiens_hsa003100.69224747
77Cocaine addiction_Homo sapiens_hsa050300.68614324
78Ras signaling pathway_Homo sapiens_hsa040140.68482308
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.67199344
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66643945
81Non-small cell lung cancer_Homo sapiens_hsa052230.66460124
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66267568
83One carbon pool by folate_Homo sapiens_hsa006700.66172182
84Dopaminergic synapse_Homo sapiens_hsa047280.65926889
85Viral carcinogenesis_Homo sapiens_hsa052030.64755655
86Fatty acid degradation_Homo sapiens_hsa000710.64676834
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64423457
88Mismatch repair_Homo sapiens_hsa034300.64107084
89Pancreatic cancer_Homo sapiens_hsa052120.63862255
90Carbon metabolism_Homo sapiens_hsa012000.63456958
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62559994
92Circadian entrainment_Homo sapiens_hsa047130.62205418
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.61604569
94Circadian rhythm_Homo sapiens_hsa047100.61505542
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60608866
96Amoebiasis_Homo sapiens_hsa051460.60329838
97Estrogen signaling pathway_Homo sapiens_hsa049150.59921553
98Insulin secretion_Homo sapiens_hsa049110.59021860
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58332455
100Non-homologous end-joining_Homo sapiens_hsa034500.58268339
101Thyroid cancer_Homo sapiens_hsa052160.57846702
102DNA replication_Homo sapiens_hsa030300.57595062
103Selenocompound metabolism_Homo sapiens_hsa004500.57384919
104HTLV-I infection_Homo sapiens_hsa051660.57216112
105Dorso-ventral axis formation_Homo sapiens_hsa043200.56891789
106Nucleotide excision repair_Homo sapiens_hsa034200.56854234
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56299624
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55931453
109PPAR signaling pathway_Homo sapiens_hsa033200.55635843
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55200726
111p53 signaling pathway_Homo sapiens_hsa041150.54954065
112Olfactory transduction_Homo sapiens_hsa047400.53804427
113Calcium signaling pathway_Homo sapiens_hsa040200.52628815
114Renin secretion_Homo sapiens_hsa049240.52095795
115AMPK signaling pathway_Homo sapiens_hsa041520.51617443
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51493237
117Basal transcription factors_Homo sapiens_hsa030220.51206303
118Thyroid hormone synthesis_Homo sapiens_hsa049180.51048478
119Fatty acid biosynthesis_Homo sapiens_hsa000610.50903467
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.50571502
121Folate biosynthesis_Homo sapiens_hsa007900.49958796
122Gastric acid secretion_Homo sapiens_hsa049710.49570753
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.49545713
124Cholinergic synapse_Homo sapiens_hsa047250.49244522
125N-Glycan biosynthesis_Homo sapiens_hsa005100.48617408
126Glutamatergic synapse_Homo sapiens_hsa047240.47266049
127Inositol phosphate metabolism_Homo sapiens_hsa005620.46897767
128Serotonergic synapse_Homo sapiens_hsa047260.46079260
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45597567
130beta-Alanine metabolism_Homo sapiens_hsa004100.45161284
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.44471436
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43899089
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43798764
134cAMP signaling pathway_Homo sapiens_hsa040240.43643343
135Glutathione metabolism_Homo sapiens_hsa004800.43089705

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