RHOC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)4.88750685
2collagen fibril organization (GO:0030199)4.36253687
3endodermal cell differentiation (GO:0035987)4.35153932
4wound healing, spreading of epidermal cells (GO:0035313)4.30570065
5cell adhesion mediated by integrin (GO:0033627)4.17356445
6protein heterotrimerization (GO:0070208)4.15871529
7apoptotic cell clearance (GO:0043277)4.13942412
8regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.05594199
9barbed-end actin filament capping (GO:0051016)4.03906275
10protein maturation by protein folding (GO:0022417)4.00320819
11basement membrane organization (GO:0071711)4.00097346
12protein localization to endosome (GO:0036010)3.99795820
13regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.87126736
14skin morphogenesis (GO:0043589)3.86028210
15plasma membrane repair (GO:0001778)3.73877070
16epithelial cell-cell adhesion (GO:0090136)3.71510210
17positive regulation of endothelial cell apoptotic process (GO:2000353)3.71166140
18endothelial cell morphogenesis (GO:0001886)3.70904740
19regulation of tight junction assembly (GO:2000810)3.57883892
20negative regulation of fatty acid transport (GO:2000192)3.56516519
21wound healing, spreading of cells (GO:0044319)3.53090415
22vascular endothelial growth factor signaling pathway (GO:0038084)3.49904406
23collagen metabolic process (GO:0032963)3.43477929
24type B pancreatic cell proliferation (GO:0044342)3.39397591
25regulation of metalloenzyme activity (GO:0048552)3.33992398
26virion attachment to host cell (GO:0019062)3.32435088
27adhesion of symbiont to host cell (GO:0044650)3.32435088
28retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.31022576
29peptidyl-proline hydroxylation (GO:0019511)3.30359099
30retina vasculature morphogenesis in camera-type eye (GO:0061299)3.28733532
31collagen catabolic process (GO:0030574)3.27947950
32hemidesmosome assembly (GO:0031581)3.27441794
33multicellular organismal macromolecule metabolic process (GO:0044259)3.24760268
34low-density lipoprotein particle clearance (GO:0034383)3.23791277
35extracellular matrix disassembly (GO:0022617)3.18161402
36stress fiber assembly (GO:0043149)3.16485022
37regulation of integrin-mediated signaling pathway (GO:2001044)3.14590815
38desmosome organization (GO:0002934)3.13661553
39cellular response to vitamin (GO:0071295)3.13473900
40axon extension involved in axon guidance (GO:0048846)3.12285485
41neuron projection extension involved in neuron projection guidance (GO:1902284)3.12285485
42multicellular organismal catabolic process (GO:0044243)3.11714677
43multicellular organismal metabolic process (GO:0044236)3.09853583
44adhesion of symbiont to host (GO:0044406)3.09004435
45sequestering of extracellular ligand from receptor (GO:0035581)3.07211165
46negative regulation of smooth muscle cell migration (GO:0014912)3.04696916
47regulation of early endosome to late endosome transport (GO:2000641)3.04349473
48GDP-mannose metabolic process (GO:0019673)3.02164013
49cell-substrate junction assembly (GO:0007044)3.01609801
50positive regulation of pseudopodium assembly (GO:0031274)3.01604293
51maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98072648
52positive regulation of p38MAPK cascade (GO:1900745)2.97272405
53cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.96368330
54pinocytosis (GO:0006907)2.94605893
55endothelial cell chemotaxis (GO:0035767)2.94372005
56substrate adhesion-dependent cell spreading (GO:0034446)2.93577373
57hyaluronan catabolic process (GO:0030214)2.93182966
58renal filtration (GO:0097205)2.92683857
59actin filament depolymerization (GO:0030042)2.92215053
60protein retention in ER lumen (GO:0006621)2.92192702
61positive regulation of Cdc42 GTPase activity (GO:0043089)2.91778953
62positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.91435453
63proline biosynthetic process (GO:0006561)2.90230251
64cellular response to vitamin D (GO:0071305)2.87478335
65regulation of extracellular matrix disassembly (GO:0010715)2.87197682
66cellular response to interferon-alpha (GO:0035457)2.86979584
67endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.86594054
68protein hydroxylation (GO:0018126)2.85888017
69regulation of apoptotic process involved in morphogenesis (GO:1902337)2.85278871
70branching involved in salivary gland morphogenesis (GO:0060445)2.84392156
71sarcomere organization (GO:0045214)2.84364874
72positive regulation of epithelial to mesenchymal transition (GO:0010718)2.79878228
73positive regulation of blood vessel endothelial cell migration (GO:0043536)2.79241538
74muscle cell migration (GO:0014812)2.75658475
75endocardial cushion development (GO:0003197)2.75558572
76cell migration involved in sprouting angiogenesis (GO:0002042)2.75285219
77bone trabecula formation (GO:0060346)2.72551475
78cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.70784090
79nucleotide-sugar biosynthetic process (GO:0009226)2.68813527
80positive regulation of osteoblast proliferation (GO:0033690)2.68695214
81membrane raft organization (GO:0031579)2.68228033
82Golgi transport vesicle coating (GO:0048200)2.67822690
83COPI coating of Golgi vesicle (GO:0048205)2.67822690
84regulation of SMAD protein import into nucleus (GO:0060390)2.66620492
85dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.65381955
86mesodermal cell differentiation (GO:0048333)2.65267580
87glomerular basement membrane development (GO:0032836)2.65247451
88regulation of pseudopodium assembly (GO:0031272)2.63285648
89hippo signaling (GO:0035329)2.62221903
90blood vessel endothelial cell migration (GO:0043534)2.58913137
91endocytic recycling (GO:0032456)2.58568494
92positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.57755035
93positive regulation of receptor recycling (GO:0001921)2.57614617
94membrane protein ectodomain proteolysis (GO:0006509)2.56056127
95lymphangiogenesis (GO:0001946)2.54313239
96mesenchymal-epithelial cell signaling (GO:0060638)2.53235698
97cellular response to nutrient (GO:0031670)2.53024173
98regulation of integrin activation (GO:0033623)2.52903302
99adherens junction assembly (GO:0034333)2.52879863
100fibril organization (GO:0097435)2.52527099
101endothelium development (GO:0003158)2.52455356
102regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.52343934
103actin-myosin filament sliding (GO:0033275)2.51376433
104muscle filament sliding (GO:0030049)2.51376433
105atrioventricular valve morphogenesis (GO:0003181)2.50140283
106extracellular matrix organization (GO:0030198)2.49982629
107negative regulation of chondrocyte differentiation (GO:0032331)2.49591457
108positive regulation of extracellular matrix organization (GO:1903055)2.49536233
109cellular copper ion homeostasis (GO:0006878)2.49344558
110extracellular structure organization (GO:0043062)2.48836703
111fibroblast migration (GO:0010761)2.48736961
112substrate-dependent cell migration (GO:0006929)2.48356084
113nuclear envelope reassembly (GO:0031468)2.47407493
114mitotic nuclear envelope reassembly (GO:0007084)2.47407493
115vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.47327904
116positive regulation of actin filament depolymerization (GO:0030836)2.47077003
117glomerular filtration (GO:0003094)2.47016623
118vesicle coating (GO:0006901)2.46727028
119positive regulation of endothelial cell migration (GO:0010595)2.46117192
120polarized epithelial cell differentiation (GO:0030859)2.45906083
121focal adhesion assembly (GO:0048041)2.45277555
122cell-substrate adherens junction assembly (GO:0007045)2.45277555
123bundle of His cell to Purkinje myocyte communication (GO:0086069)2.45215563
124UV protection (GO:0009650)2.45213146
125positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.45141748
126response to fluid shear stress (GO:0034405)2.43608685
127regulation of p38MAPK cascade (GO:1900744)2.41328390
128NADH metabolic process (GO:0006734)2.41148819
129extracellular fibril organization (GO:0043206)2.41103242
130fibrinolysis (GO:0042730)2.40710863
131regulation of membrane protein ectodomain proteolysis (GO:0051043)2.39945827
132platelet degranulation (GO:0002576)2.39825294
133activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.39323820
134response to laminar fluid shear stress (GO:0034616)2.38517762
135negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.38179045
136endothelial tube morphogenesis (GO:0061154)2.38087643
137morphogenesis of an endothelium (GO:0003159)2.38087643
138actin-mediated cell contraction (GO:0070252)2.38017801
139dermatan sulfate biosynthetic process (GO:0030208)2.37963326
140embryo implantation (GO:0007566)2.37510787
141positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.35913893
1424-hydroxyproline metabolic process (GO:0019471)2.35653618
143COPII vesicle coating (GO:0048208)2.32365919
144semaphorin-plexin signaling pathway (GO:0071526)2.31545010
145positive regulation of epithelial cell migration (GO:0010634)2.31401876
146glycosphingolipid catabolic process (GO:0046479)2.31222425
147regulation of plasminogen activation (GO:0010755)2.30554895
148angiogenesis involved in wound healing (GO:0060055)2.29792775
149amyloid precursor protein catabolic process (GO:0042987)2.28516184

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.74280555
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.56901435
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse4.96730329
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.34993127
5CLOCK_20551151_ChIP-Seq_293T_Human3.31028237
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.04608636
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.95753665
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.93609204
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.70766677
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.70355048
11* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.60379402
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.43328249
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.38538828
14* ELK3_25401928_ChIP-Seq_HUVEC_Human2.35019495
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.22455365
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.12622629
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.11001533
18CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.04006305
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01981401
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.97065826
21* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.94726907
22SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.92399098
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.90961852
24ATF3_27146783_Chip-Seq_COLON_Human1.86757643
25* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.82113442
26* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.82113442
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.79043993
28* CJUN_26792858_Chip-Seq_BT549_Human1.78854137
29* RACK7_27058665_Chip-Seq_MCF-7_Human1.78236847
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.74232014
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.71059239
32SOX2_20726797_ChIP-Seq_SW620_Human1.69817875
33JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62685114
34* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54585088
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.53967440
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51769959
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50406247
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49454215
39* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47237646
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.46709972
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44207208
42* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43944891
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.42855198
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.42112910
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.41679330
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.40900456
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38833222
48* BRD4_25478319_ChIP-Seq_HGPS_Human1.38709462
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38636929
50* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.38403496
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37391500
52JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36876715
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.36833148
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36807327
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35675287
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34151033
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33953528
58UBF1/2_26484160_Chip-Seq_HMECs_Human1.33820092
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.32126647
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31170212
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31077363
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.30906787
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.30906787
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28670369
65* LXR_22292898_ChIP-Seq_THP-1_Human1.28260148
66TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26557239
67TP53_22127205_ChIP-Seq_IMR90_Human1.25014676
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24587178
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24295500
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23620495
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23620495
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22560379
73ZNF263_19887448_ChIP-Seq_K562_Human1.22551317
74ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21727593
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20664707
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20161856
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19951287
78CDX2_20551321_ChIP-Seq_CACO-2_Human1.19740834
79* VDR_21846776_ChIP-Seq_THP-1_Human1.18050805
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17998472
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17546777
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17049162
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16073592
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14834591
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11409251
86* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11327615
87* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10508225
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08117475
89SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06814518
90* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05997737
91NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04942385
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04687941
93SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03312787
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02696410
95MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02084867
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.00948670
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99284562
98KLF5_25053715_ChIP-Seq_YYC3_Human0.98981644
99TP53_20018659_ChIP-ChIP_R1E_Mouse0.97680995
100ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97012045
101TP53_23651856_ChIP-Seq_MEFs_Mouse0.95180882
102ELK1_22589737_ChIP-Seq_MCF10A_Human0.95055985
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95037919
104GATA4_25053715_ChIP-Seq_YYC3_Human0.94208981
105* GATA6_25053715_ChIP-Seq_YYC3_Human0.91165317
106P68_20966046_ChIP-Seq_HELA_Human0.90899347
107* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90855684
108FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90584720
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89858789
110ESR1_20079471_ChIP-ChIP_T-47D_Human0.89570315
111KDM2B_26808549_Chip-Seq_DND41_Human0.89521567
112* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89474901
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89116385
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88023419
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86693790
116SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86548184
117AR_21909140_ChIP-Seq_LNCAP_Human0.86461576
118KDM2B_26808549_Chip-Seq_K562_Human0.86439257
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86259714
120* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86195455
121* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85866838
122* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85716022
123* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85303104
124* RUNX1_27514584_Chip-Seq_MCF-7_Human0.85231475
125* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85170843
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84916948
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.84745696
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84701899
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83661744
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.83367086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.97257697
2MP0003705_abnormal_hypodermis_morpholog4.30687232
3MP0005275_abnormal_skin_tensile3.56770970
4MP0003279_aneurysm3.46160456
5MP0004272_abnormal_basement_membrane3.15427251
6MP0005503_abnormal_tendon_morphology3.12409408
7MP0003566_abnormal_cell_adhesion2.85308042
8MP0005623_abnormal_meninges_morphology2.67999338
9MP0001958_emphysema2.63561215
10MP0006054_spinal_hemorrhage2.33214344
11MP0003191_abnormal_cellular_cholesterol2.20906457
12MP0005023_abnormal_wound_healing2.20312356
13MP0010030_abnormal_orbit_morphology2.13626477
14MP0005360_urolithiasis1.99699976
15MP0010368_abnormal_lymphatic_system1.97745347
16MP0010352_gastrointestinal_tract_polyps1.96236911
17MP0003091_abnormal_cell_migration1.94582511
18MP0005257_abnormal_intraocular_pressure1.93456565
19MP0009384_cardiac_valve_regurgitation1.83633102
20MP0005451_abnormal_body_composition1.76763638
21MP0000750_abnormal_muscle_regeneration1.76027788
22MP0000733_abnormal_muscle_development1.74317455
23MP0004084_abnormal_cardiac_muscle1.71355362
24MP0005508_abnormal_skeleton_morphology1.69204141
25MP0002877_abnormal_melanocyte_morpholog1.58808040
26MP0002295_abnormal_pulmonary_circulatio1.52769825
27MP0010234_abnormal_vibrissa_follicle1.52599438
28MP0002060_abnormal_skin_morphology1.49467617
29MP0001542_abnormal_bone_strength1.47054963
30MP0000767_abnormal_smooth_muscle1.45771614
31MP0008260_abnormal_autophagy1.42383892
32MP0003385_abnormal_body_wall1.39636714
33MP0001879_abnormal_lymphatic_vessel1.39591750
34MP0009053_abnormal_anal_canal1.38753580
35MP0005501_abnormal_skin_physiology1.36134979
36MP0002796_impaired_skin_barrier1.35956204
37MP0002896_abnormal_bone_mineralization1.32200473
38MP0000343_altered_response_to1.30135373
39MP0004510_myositis1.28148089
40MP0000749_muscle_degeneration1.24042852
41MP0005409_darkened_coat_color1.21861791
42MP0009250_abnormal_appendicular_skeleto1.20286268
43MP0003045_fibrosis1.18827094
44MP0003950_abnormal_plasma_membrane1.18149284
45MP0000013_abnormal_adipose_tissue1.17120545
46MP0003941_abnormal_skin_development1.16647788
47MP0005390_skeleton_phenotype1.14446068
48MP0009780_abnormal_chondrocyte_physiolo1.14037038
49MP0001849_ear_inflammation1.13224204
50MP0005595_abnormal_vascular_smooth1.12599517
51MP0005058_abnormal_lysosome_morphology1.12314393
52MP0004087_abnormal_muscle_fiber1.12146621
53MP0002282_abnormal_trachea_morphology1.11608744
54MP0000751_myopathy1.10882382
55MP0005164_abnormal_response_to1.08391895
56MP0001533_abnormal_skeleton_physiology1.04416896
57MP0001243_abnormal_dermal_layer1.03437992
58MP0000163_abnormal_cartilage_morphology1.02364132
59MP0003300_gastrointestinal_ulcer1.02319110
60MP0003806_abnormal_nucleotide_metabolis1.02305259
61MP0003448_altered_tumor_morphology1.01654411
62MP0008775_abnormal_heart_ventricle1.00636278
63MP0000534_abnormal_ureter_morphology1.00541943
64MP0003453_abnormal_keratinocyte_physiol0.99426091
65MP0005330_cardiomyopathy0.98544422
66MP0002998_abnormal_bone_remodeling0.98156576
67MP0003828_pulmonary_edema0.98130247
68MP0002168_other_aberrant_phenotype0.97184395
69MP0002972_abnormal_cardiac_muscle0.96411481
70MP0000537_abnormal_urethra_morphology0.95941215
71MP0006138_congestive_heart_failure0.95201368
72MP0001614_abnormal_blood_vessel0.94670142
73MP0002128_abnormal_blood_circulation0.93950618
74MP0001216_abnormal_epidermal_layer0.93053231
75MP0003942_abnormal_urinary_system0.92512591
76MP0002933_joint_inflammation0.92101712
77MP0002139_abnormal_hepatobiliary_system0.92094384
78MP0010630_abnormal_cardiac_muscle0.91585160
79MP0005076_abnormal_cell_differentiation0.91518659
80* MP0000858_altered_metastatic_potential0.91263405
81MP0004233_abnormal_muscle_weight0.90084261
82MP0000467_abnormal_esophagus_morphology0.89880253
83MP0002115_abnormal_skeleton_extremities0.89184022
84MP0004858_abnormal_nervous_system0.89004219
85MP0003075_altered_response_to0.88898342
86MP0003186_abnormal_redox_activity0.87667561
87MP0009840_abnormal_foam_cell0.87646898
88MP0005385_cardiovascular_system_phenoty0.87219543
89MP0001544_abnormal_cardiovascular_syste0.87219543
90MP0001299_abnormal_eye_distance/0.86457483
91MP0002113_abnormal_skeleton_development0.85176576
92MP0005197_abnormal_uvea_morphology0.84482133
93MP0000759_abnormal_skeletal_muscle0.83871812
94MP0000678_abnormal_parathyroid_gland0.83100331
95MP0002108_abnormal_muscle_morphology0.82854094
96MP0001915_intracranial_hemorrhage0.82691389
97MP0004947_skin_inflammation0.82281240
98MP0000762_abnormal_tongue_morphology0.80114012
99MP0005367_renal/urinary_system_phenotyp0.79881652
100MP0000516_abnormal_urinary_system0.79881652
101MP0005165_increased_susceptibility_to0.79847955
102MP0000249_abnormal_blood_vessel0.77889283
103MP0003115_abnormal_respiratory_system0.77874775
104MP0002925_abnormal_cardiovascular_devel0.77456472
105MP0004883_abnormal_blood_vessel0.76562936
106MP0002837_dystrophic_cardiac_calcinosis0.76071429
107MP0003795_abnormal_bone_structure0.75753383
108MP0005166_decreased_susceptibility_to0.75339986
109MP0003329_amyloid_beta_deposits0.74941482
110MP0000003_abnormal_adipose_tissue0.73313973
111MP0009278_abnormal_bone_marrow0.72885085
112MP0010771_integument_phenotype0.72587882
113MP0005167_abnormal_blood-brain_barrier0.72583751
114MP0004264_abnormal_extraembryonic_tissu0.71577847
115MP0004036_abnormal_muscle_relaxation0.70911119
116MP0005248_abnormal_Harderian_gland0.70876006
117MP0004134_abnormal_chest_morphology0.70757810
118MP0004185_abnormal_adipocyte_glucose0.69908732
119MP0000428_abnormal_craniofacial_morphol0.69798819
120MP0003283_abnormal_digestive_organ0.69196746
121MP0005620_abnormal_muscle_contractility0.68659927
122MP0001666_abnormal_nutrient_absorption0.68558319
123MP0003303_peritoneal_inflammation0.68132814
124MP0001881_abnormal_mammary_gland0.67848005
125MP0002932_abnormal_joint_morphology0.67816426
126MP0005375_adipose_tissue_phenotype0.67322724
127MP0002089_abnormal_postnatal_growth/wei0.67257841
128MP0005464_abnormal_platelet_physiology0.66271176
129MP0006082_CNS_inflammation0.65900191
130MP0009379_abnormal_foot_pigmentation0.65042802
131MP0000747_muscle_weakness0.64571830
132MP0000462_abnormal_digestive_system0.63191445
133MP0005365_abnormal_bile_salt0.63079999
134MP0005193_abnormal_anterior_eye0.62614409
135MP0009643_abnormal_urine_homeostasis0.60465197
136MP0005083_abnormal_biliary_tract0.59810041

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.82654124
2Premature rupture of membranes (HP:0001788)6.82517466
3Atrophic scars (HP:0001075)4.08274781
4Aortic dissection (HP:0002647)4.01470340
5Shallow orbits (HP:0000586)4.00735200
6Peritonitis (HP:0002586)3.80193623
7Cerebral aneurysm (HP:0004944)3.76675968
8Cervical subluxation (HP:0003308)3.69558034
9Increased connective tissue (HP:0009025)3.65057948
10Ankle contracture (HP:0006466)3.64895640
11Vertebral compression fractures (HP:0002953)3.64021520
12Aortic aneurysm (HP:0004942)3.59758965
13Soft skin (HP:0000977)3.38388967
14Fragile skin (HP:0001030)3.36884395
15Right ventricular cardiomyopathy (HP:0011663)3.32471336
16Broad metatarsal (HP:0001783)3.32181553
17Abnormality of dentin (HP:0010299)3.28873357
18Spinal rigidity (HP:0003306)3.27016089
19Dilatation of the ascending aorta (HP:0005111)3.12454897
20Wormian bones (HP:0002645)3.08672925
21Type 1 muscle fiber predominance (HP:0003803)3.04508186
22Blue sclerae (HP:0000592)3.04353359
23Neonatal short-limb short stature (HP:0008921)2.97026349
24Bladder diverticulum (HP:0000015)2.96339303
25Muscle fiber splitting (HP:0003555)2.70835960
26Vascular tortuosity (HP:0004948)2.60090550
27Biconcave vertebral bodies (HP:0004586)2.59852024
28Osteolytic defects of the hand bones (HP:0009699)2.58708280
29Osteolytic defects of the phalanges of the hand (HP:0009771)2.58708280
30Abnormality of the acetabulum (HP:0003170)2.56919147
31Achilles tendon contracture (HP:0001771)2.54339738
32Mildly elevated creatine phosphokinase (HP:0008180)2.51263262
33Genu recurvatum (HP:0002816)2.49479519
34Mitral valve prolapse (HP:0001634)2.49123710
35Wrist flexion contracture (HP:0001239)2.48369090
36Scapular winging (HP:0003691)2.47040183
37Difficulty climbing stairs (HP:0003551)2.46121348
38Flat acetabular roof (HP:0003180)2.43072563
39Short nail (HP:0001799)2.41363828
40Aneurysm (HP:0002617)2.40759658
41Abnormality of the Achilles tendon (HP:0005109)2.39898151
42Abnormality of glycolipid metabolism (HP:0010969)2.39322251
43Abnormality of liposaccharide metabolism (HP:0010968)2.39322251
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.39322251
45Cardiovascular calcification (HP:0011915)2.39030074
46Cupped ribs (HP:0000887)2.38787801
47Thin bony cortex (HP:0002753)2.34805722
48Reduced subcutaneous adipose tissue (HP:0003758)2.32532305
49Coxa vara (HP:0002812)2.30878204
50Axonal loss (HP:0003447)2.28795241
51Arterial tortuosity (HP:0005116)2.28197704
52Follicular hyperkeratosis (HP:0007502)2.27881179
53Distal upper limb amyotrophy (HP:0007149)2.25406123
54Upper limb amyotrophy (HP:0009129)2.25406123
55Elbow flexion contracture (HP:0002987)2.24820080
56Ulnar bowing (HP:0003031)2.24765263
57Distal lower limb muscle weakness (HP:0009053)2.22856055
58Abnormal delivery (HP:0001787)2.21053283
59Hyperextensible skin (HP:0000974)2.20985898
60Mitral stenosis (HP:0001718)2.20362988
61Dysostosis multiplex (HP:0000943)2.14823415
62Abnormality of carpal bone ossification (HP:0006257)2.14225370
63Abnormality of the umbilical cord (HP:0010881)2.13519770
64Nuclear cataract (HP:0100018)2.13386168
65Myocardial infarction (HP:0001658)2.12975731
66Platyspondyly (HP:0000926)2.11553964
67Hyporeflexia of lower limbs (HP:0002600)2.10899730
68Ventricular tachycardia (HP:0004756)2.10593781
69Vascular calcification (HP:0004934)2.07830296
70Entropion (HP:0000621)2.05044976
71Radial bowing (HP:0002986)2.02755894
72Increased variability in muscle fiber diameter (HP:0003557)2.02102654
73Hyperacusis (HP:0010780)2.00475517
74Natal tooth (HP:0000695)1.99604773
75Abnormality of glutamine family amino acid metabolism (HP:0010902)1.98362118
76Abnormal ossification of hand bones (HP:0005921)1.97675472
77Nonimmune hydrops fetalis (HP:0001790)1.97610798
78Mucopolysacchariduria (HP:0008155)1.96842558
79Urinary glycosaminoglycan excretion (HP:0003541)1.96842558
80Hemorrhage of the eye (HP:0011885)1.96555837
81Camptodactyly of toe (HP:0001836)1.95144825
82Trismus (HP:0000211)1.94825540
83Distal lower limb amyotrophy (HP:0008944)1.94447728
84Congenital glaucoma (HP:0001087)1.92218860
85Abnormality of polysaccharide metabolism (HP:0011012)1.91842317
86Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91842317
87Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91842317
88Overgrowth (HP:0001548)1.91539748
89Beaking of vertebral bodies (HP:0004568)1.91044578
90Broad face (HP:0000283)1.91014595
91Abnormality of the distal phalanges of the toes (HP:0010182)1.90679473
92Mesangial abnormality (HP:0001966)1.90045839
93J-shaped sella turcica (HP:0002680)1.89654247
94Wide anterior fontanel (HP:0000260)1.88178745
95Short hallux (HP:0010109)1.87740001
96Joint laxity (HP:0001388)1.87220574
97Hand muscle atrophy (HP:0009130)1.87161950
98Abnormality of skeletal muscle fiber size (HP:0012084)1.87087988
99Hyperparathyroidism (HP:0000843)1.85481038
100Abnormality of the calcaneus (HP:0008364)1.84829804
101Knee flexion contracture (HP:0006380)1.84470941
102Tarsal synostosis (HP:0008368)1.84080269
103Deviation of the hallux (HP:0010051)1.84078277
104Bowing of the arm (HP:0006488)1.82972178
105Bowed forearm bones (HP:0003956)1.82972178
106Hydroxyprolinuria (HP:0003080)1.82882439
107Abnormality of proline metabolism (HP:0010907)1.82882439
108Round ear (HP:0100830)1.82529590
109Increased density of long bones (HP:0006392)1.82390032
110Lipoatrophy (HP:0100578)1.82188339
111Osteopenia (HP:0000938)1.79853542
112Generalized amyotrophy (HP:0003700)1.79630718
113Joint stiffness (HP:0001387)1.78826413
114Ileus (HP:0002595)1.78395122
115Spinal cord compression (HP:0002176)1.77310766
116Asymmetric septal hypertrophy (HP:0001670)1.76951940
117Abnormal gallbladder physiology (HP:0012438)1.76398788
118Cholecystitis (HP:0001082)1.76398788
119Tibial bowing (HP:0002982)1.75224053
120Glucose intolerance (HP:0000833)1.75050602
121Aplasia/Hypoplasia of the hallux (HP:0008362)1.73445982
122Ectopia lentis (HP:0001083)1.73173774
123Ovoid vertebral bodies (HP:0003300)1.73088398
124Spondylolisthesis (HP:0003302)1.72673527
125Persistence of primary teeth (HP:0006335)1.72429573
126Femoral bowing (HP:0002980)1.71497047
127Hip contracture (HP:0003273)1.71348142
128Pterygium (HP:0001059)1.71077725
129Malnutrition (HP:0004395)1.70954427
130EMG: myopathic abnormalities (HP:0003458)1.70877666
131Mitral regurgitation (HP:0001653)1.70790233
132Osteoarthritis (HP:0002758)1.70658589
133Systemic lupus erythematosus (HP:0002725)1.70314019
134Long toe (HP:0010511)1.70282561
135Aortic regurgitation (HP:0001659)1.70237219
136Disproportionate tall stature (HP:0001519)1.70134479
137Back pain (HP:0003418)1.69860226
138Limb-girdle muscle atrophy (HP:0003797)1.69835426
139Bowel diverticulosis (HP:0005222)1.68580417
140Abnormality of the peritoneum (HP:0002585)1.68569003
141Abnormal vertebral ossification (HP:0100569)1.68010103
142Hallux valgus (HP:0001822)1.66381199
143Coronal craniosynostosis (HP:0004440)1.66149353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.15299925
2TTN3.43258002
3DDR23.10109254
4IRAK32.97472194
5TESK12.90090818
6ERN12.84606854
7PKN22.83213993
8EPHB22.48310048
9EPHA22.44330777
10LIMK12.29472874
11LATS22.23958542
12PDGFRA2.23340699
13PIM22.22705997
14MYLK2.09268867
15RIPK12.06518700
16MET1.82314722
17MAP3K121.79186329
18BMX1.79126556
19PAK41.75561986
20LRRK21.72119120
21PTK61.69772076
22PTK21.67682913
23TESK21.67207188
24MST1R1.66943074
25PIK3CA1.65391475
26KDR1.60327613
27PAK21.56125045
28FER1.53035525
29EPHB11.52686060
30TRPM71.48788434
31MAP3K31.47965973
32SMG11.45800912
33LATS11.41516105
34NME21.40625147
35RPS6KA41.39305794
36ILK1.39179926
37PTK2B1.25809545
38TGFBR21.23468759
39DAPK31.15021343
40STK38L1.14191374
41PRKG21.13175559
42EPHA31.12313141
43DMPK1.10974193
44ICK1.09608997
45MAP2K31.08273964
46TIE11.08262847
47PRPF4B1.05647602
48TBK11.05591642
49ERBB41.04544662
50SIK11.03994269
51PAK31.03282065
52MAP2K21.02270784
53MAP2K11.01599662
54MOS1.00294286
55LMTK21.00044783
56MAPKAPK30.97159194
57NEK90.94348577
58VRK20.92666567
59STK100.92444818
60ROCK10.92003012
61PAK10.81854059
62ABL20.81815141
63MAP3K80.78031252
64PIK3CG0.76600267
65MAP3K110.76483740
66PDGFRB0.74576272
67PRKD20.74125151
68TGFBR10.73739785
69MAP3K100.71184327
70NEK10.70478128
71PBK0.70343569
72FGFR10.69543899
73STK30.67658798
74ZAP700.66856319
75PDK20.66413737
76TAOK10.66091337
77BRAF0.65574328
78PRKD10.64419402
79SIK30.64267218
80FRK0.64035863
81ARAF0.63124290
82MTOR0.60358906
83EEF2K0.58632277
84EIF2AK10.57900440
85ROCK20.57661305
86CDK80.55657408
87MUSK0.55637678
88DYRK1B0.51646861
89CAMK2G0.50423165
90CDC42BPA0.50083491
91SCYL20.49312403
92PDPK10.48614738
93FGFR40.47375906
94RPS6KA20.46915371
95CAMK1D0.46303885
96MAPKAPK20.46116991
97CDK60.45811674
98RET0.45410593
99NTRK10.44967641
100RPS6KB20.44682447
101ERBB30.44569492
102STK380.44505363
103FLT30.41954709
104TAOK20.41448194
105PRKCI0.41158995
106WNK40.40668442
107INSR0.39375475
108MAP3K10.39368620
109KSR20.38993770
110SRC0.38163199
111PRKD30.38059567
112DAPK10.37565780
113MAP3K60.35358790
114BUB10.31406382
115MST40.31279430
116CHUK0.31144687
117TYK20.30848565
118AKT20.30748536
119MAP3K20.29995038
120CSK0.29787818
121PAK60.27482606
122CAMK2D0.27372527
123MATK0.27242460
124MARK30.26607107
125GSK3A0.26050396
126JAK30.25951908
127EGFR0.25658990
128AURKA0.23562802
129MELK0.23510029

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.46354434
2Focal adhesion_Homo sapiens_hsa045102.72393636
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.50110971
4Fructose and mannose metabolism_Homo sapiens_hsa000512.36511213
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.33798936
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.31655384
7Bladder cancer_Homo sapiens_hsa052192.17323960
8Sulfur relay system_Homo sapiens_hsa041222.13177070
9Proteoglycans in cancer_Homo sapiens_hsa052052.11827429
10Adherens junction_Homo sapiens_hsa045202.09195749
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.07546197
12Amoebiasis_Homo sapiens_hsa051462.04231065
13Malaria_Homo sapiens_hsa051442.03928967
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.03487623
15Dilated cardiomyopathy_Homo sapiens_hsa054142.02815153
16Pentose phosphate pathway_Homo sapiens_hsa000301.92278470
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.88481780
18Small cell lung cancer_Homo sapiens_hsa052221.80033085
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.75856989
20Protein digestion and absorption_Homo sapiens_hsa049741.74597889
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.71984034
22Shigellosis_Homo sapiens_hsa051311.59554346
23Tight junction_Homo sapiens_hsa045301.50657699
24Biosynthesis of amino acids_Homo sapiens_hsa012301.44907717
25Chronic myeloid leukemia_Homo sapiens_hsa052201.41358380
26TGF-beta signaling pathway_Homo sapiens_hsa043501.41078515
27Viral myocarditis_Homo sapiens_hsa054161.40099573
28Hippo signaling pathway_Homo sapiens_hsa043901.40046476
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.34272946
30Salmonella infection_Homo sapiens_hsa051321.34145632
31Lysosome_Homo sapiens_hsa041421.32020836
32N-Glycan biosynthesis_Homo sapiens_hsa005101.29853206
33Phagosome_Homo sapiens_hsa041451.29415747
34TNF signaling pathway_Homo sapiens_hsa046681.25813043
35Regulation of actin cytoskeleton_Homo sapiens_hsa048101.25520840
36Toxoplasmosis_Homo sapiens_hsa051451.24023980
37HIF-1 signaling pathway_Homo sapiens_hsa040661.22857079
38Leishmaniasis_Homo sapiens_hsa051401.19610269
39MicroRNAs in cancer_Homo sapiens_hsa052061.19453972
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.19196903
41Pertussis_Homo sapiens_hsa051331.18545711
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17423291
43Apoptosis_Homo sapiens_hsa042101.15726826
44Legionellosis_Homo sapiens_hsa051341.11781818
45Mineral absorption_Homo sapiens_hsa049781.10973889
46Galactose metabolism_Homo sapiens_hsa000521.08940837
47Fatty acid elongation_Homo sapiens_hsa000621.07249784
48Sphingolipid metabolism_Homo sapiens_hsa006001.07183903
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05375996
50Proteasome_Homo sapiens_hsa030501.04663410
51Melanoma_Homo sapiens_hsa052181.03974249
52Glutathione metabolism_Homo sapiens_hsa004801.03926090
53p53 signaling pathway_Homo sapiens_hsa041151.03315823
54Arginine biosynthesis_Homo sapiens_hsa002201.01297155
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94329501
56Phenylalanine metabolism_Homo sapiens_hsa003600.92362909
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92321435
58Pancreatic cancer_Homo sapiens_hsa052120.87221783
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.86627963
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.84912384
61Other glycan degradation_Homo sapiens_hsa005110.84420167
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84133252
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81135473
64Renin-angiotensin system_Homo sapiens_hsa046140.77820672
65Rheumatoid arthritis_Homo sapiens_hsa053230.77364523
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76405602
67Tuberculosis_Homo sapiens_hsa051520.75640914
68Pathways in cancer_Homo sapiens_hsa052000.75038067
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74977057
70Sulfur metabolism_Homo sapiens_hsa009200.74945698
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74804858
72Starch and sucrose metabolism_Homo sapiens_hsa005000.71811675
73Rap1 signaling pathway_Homo sapiens_hsa040150.71391500
74Folate biosynthesis_Homo sapiens_hsa007900.71252293
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71115644
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.71090856
77Prion diseases_Homo sapiens_hsa050200.70583146
78Basal cell carcinoma_Homo sapiens_hsa052170.70425018
79Fat digestion and absorption_Homo sapiens_hsa049750.69479172
80Thyroid cancer_Homo sapiens_hsa052160.69059113
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68708875
82Prostate cancer_Homo sapiens_hsa052150.67944669
83Osteoclast differentiation_Homo sapiens_hsa043800.67833787
84PPAR signaling pathway_Homo sapiens_hsa033200.67346941
85Renal cell carcinoma_Homo sapiens_hsa052110.66390296
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66269958
87Platelet activation_Homo sapiens_hsa046110.66149422
88Viral carcinogenesis_Homo sapiens_hsa052030.63044278
89HTLV-I infection_Homo sapiens_hsa051660.62832411
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62490576
91VEGF signaling pathway_Homo sapiens_hsa043700.60688967
92Vibrio cholerae infection_Homo sapiens_hsa051100.60363214
93Vitamin digestion and absorption_Homo sapiens_hsa049770.59691465
94Tyrosine metabolism_Homo sapiens_hsa003500.58958071
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58824638
96Carbon metabolism_Homo sapiens_hsa012000.58454863
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57992421
98Endocytosis_Homo sapiens_hsa041440.56725651
99Caffeine metabolism_Homo sapiens_hsa002320.56064097
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55200033
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54483664
102Insulin resistance_Homo sapiens_hsa049310.52783078
103Hepatitis B_Homo sapiens_hsa051610.52493303
104Arginine and proline metabolism_Homo sapiens_hsa003300.51847438
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51473961
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48452187
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47752706
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45253257
109Acute myeloid leukemia_Homo sapiens_hsa052210.43949062
110Glioma_Homo sapiens_hsa052140.43758458
111Bile secretion_Homo sapiens_hsa049760.43655506
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43362031
113Chemical carcinogenesis_Homo sapiens_hsa052040.43176161
114Hedgehog signaling pathway_Homo sapiens_hsa043400.43140071
115Fatty acid degradation_Homo sapiens_hsa000710.42333303
116Hepatitis C_Homo sapiens_hsa051600.42027369
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41987434
118Endometrial cancer_Homo sapiens_hsa052130.41280987
119Pyruvate metabolism_Homo sapiens_hsa006200.40451405
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40445275
121Notch signaling pathway_Homo sapiens_hsa043300.39043434
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37178195
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36043230
124Cardiac muscle contraction_Homo sapiens_hsa042600.35708304
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35528486
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.35214196
127Complement and coagulation cascades_Homo sapiens_hsa046100.34969696
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.32893698

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