RHOD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.29812017
2regulation of water loss via skin (GO:0033561)6.11711266
3bundle of His cell to Purkinje myocyte communication (GO:0086069)5.84711313
4establishment of skin barrier (GO:0061436)5.66016295
5keratinization (GO:0031424)5.03544049
6cellular glucuronidation (GO:0052695)5.01853033
7L-phenylalanine metabolic process (GO:0006558)4.87150677
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.87150677
9glucuronate metabolic process (GO:0019585)4.68560984
10uronic acid metabolic process (GO:0006063)4.68560984
11negative regulation of fibrinolysis (GO:0051918)4.65834443
12L-phenylalanine catabolic process (GO:0006559)4.60171220
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.60171220
14positive regulation of epidermal cell differentiation (GO:0045606)4.50093034
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.49060077
16sulfur amino acid catabolic process (GO:0000098)4.47863375
17homocysteine metabolic process (GO:0050667)4.44973972
18regulation of fibrinolysis (GO:0051917)4.42578928
19glyoxylate metabolic process (GO:0046487)4.27743578
20Golgi transport vesicle coating (GO:0048200)4.26858948
21COPI coating of Golgi vesicle (GO:0048205)4.26858948
22protein carboxylation (GO:0018214)4.24853372
23peptidyl-glutamic acid carboxylation (GO:0017187)4.24853372
24positive regulation of keratinocyte differentiation (GO:0045618)4.20094130
25multicellular organismal water homeostasis (GO:0050891)4.19110849
26aromatic amino acid family catabolic process (GO:0009074)4.17799715
27gap junction assembly (GO:0016264)4.12795961
28positive regulation of epidermis development (GO:0045684)4.11880549
29bile acid biosynthetic process (GO:0006699)4.10655906
30cysteine metabolic process (GO:0006534)4.09339236
31negative regulation of keratinocyte proliferation (GO:0010839)4.05981569
32regulation of protein activation cascade (GO:2000257)3.97261638
33high-density lipoprotein particle remodeling (GO:0034375)3.97127499
34fibrinolysis (GO:0042730)3.96438258
35negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.93712921
36kynurenine metabolic process (GO:0070189)3.92911903
37* cell-substrate junction assembly (GO:0007044)3.92907425
38indole-containing compound catabolic process (GO:0042436)3.83811098
39indolalkylamine catabolic process (GO:0046218)3.83811098
40tryptophan catabolic process (GO:0006569)3.83811098
41regulation of triglyceride catabolic process (GO:0010896)3.81815248
42positive regulation of Cdc42 GTPase activity (GO:0043089)3.81301777
43regulation of complement activation (GO:0030449)3.76774981
44protein retention in ER lumen (GO:0006621)3.74891254
45serine family amino acid biosynthetic process (GO:0009070)3.74774671
46urea cycle (GO:0000050)3.74459967
47urea metabolic process (GO:0019627)3.74459967
48glycine metabolic process (GO:0006544)3.71350758
49keratinocyte proliferation (GO:0043616)3.70336034
50tryptophan metabolic process (GO:0006568)3.67542822
51maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.65787520
52amino-acid betaine metabolic process (GO:0006577)3.57919824
53desmosome organization (GO:0002934)3.54360985
54serine family amino acid catabolic process (GO:0009071)3.51962350
55fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.51317174
56phospholipid efflux (GO:0033700)3.50726649
57complement activation, alternative pathway (GO:0006957)3.50048843
58regulation of cholesterol esterification (GO:0010872)3.46660482
59epoxygenase P450 pathway (GO:0019373)3.46547599
60serine family amino acid metabolic process (GO:0009069)3.46439515
61nitrogen cycle metabolic process (GO:0071941)3.44220297
62reverse cholesterol transport (GO:0043691)3.42477007
63response to nitrosative stress (GO:0051409)3.42154366
64negative regulation of lipase activity (GO:0060192)3.41540218
65positive regulation of fatty acid beta-oxidation (GO:0032000)3.41218460
66plasma lipoprotein particle clearance (GO:0034381)3.40828616
67water homeostasis (GO:0030104)3.40202784
68alpha-linolenic acid metabolic process (GO:0036109)3.38069075
694-hydroxyproline metabolic process (GO:0019471)3.35421335
70GDP-mannose metabolic process (GO:0019673)3.35218805
71aldehyde catabolic process (GO:0046185)3.34803621
72epithelial cell-cell adhesion (GO:0090136)3.34335707
73acylglycerol homeostasis (GO:0055090)3.34148478
74triglyceride homeostasis (GO:0070328)3.34148478
75bile acid metabolic process (GO:0008206)3.33095784
76keratinocyte development (GO:0003334)3.31876092
77dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.31387611
78activation of Rac GTPase activity (GO:0032863)3.28754901
79regulation of cholesterol homeostasis (GO:2000188)3.27774118
80xenobiotic catabolic process (GO:0042178)3.26702603
81positive regulation of triglyceride lipase activity (GO:0061365)3.22978254
82positive regulation of lipoprotein lipase activity (GO:0051006)3.22978254
83plasma lipoprotein particle remodeling (GO:0034369)3.21041048
84protein-lipid complex remodeling (GO:0034368)3.21041048
85macromolecular complex remodeling (GO:0034367)3.21041048
86positive regulation of lipid catabolic process (GO:0050996)3.20870506
87aromatic amino acid family metabolic process (GO:0009072)3.19173816
88glucose catabolic process (GO:0006007)3.19164848
89negative regulation of cholesterol transport (GO:0032375)3.16548412
90negative regulation of sterol transport (GO:0032372)3.16548412
91proline biosynthetic process (GO:0006561)3.14117211
92keratinocyte differentiation (GO:0030216)3.13528908
93tyrosine metabolic process (GO:0006570)3.12210334
94retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.11727140
95cellular modified amino acid catabolic process (GO:0042219)3.09922522
96L-serine metabolic process (GO:0006563)3.06463658
97epidermis development (GO:0008544)3.05125400
98cell differentiation involved in embryonic placenta development (GO:0060706)3.03617112
99lipoprotein metabolic process (GO:0042157)3.03473480
100flavonoid metabolic process (GO:0009812)3.03211089
101regulation of plasminogen activation (GO:0010755)3.02226306
102benzene-containing compound metabolic process (GO:0042537)3.01278184
103imidazole-containing compound metabolic process (GO:0052803)3.01063564
104lysine catabolic process (GO:0006554)3.00057330
105lysine metabolic process (GO:0006553)3.00057330
106protein maturation by protein folding (GO:0022417)2.99390963
107folic acid metabolic process (GO:0046655)2.99360950
108mitotic nuclear envelope reassembly (GO:0007084)2.99241728
109nuclear envelope reassembly (GO:0031468)2.99241728
110intestinal epithelial cell development (GO:0060576)2.99084231
111heme transport (GO:0015886)2.98255324
112positive regulation of hair follicle development (GO:0051798)2.97939567
113positive regulation of hair cycle (GO:0042635)2.97939567
114intestinal cholesterol absorption (GO:0030299)2.96435705
115surfactant homeostasis (GO:0043129)2.95421590
116atrioventricular valve morphogenesis (GO:0003181)2.94365316
117very-low-density lipoprotein particle assembly (GO:0034379)2.93982320
118pentose-phosphate shunt (GO:0006098)2.93282185
119skin morphogenesis (GO:0043589)2.92259183
120negative regulation of chondrocyte differentiation (GO:0032331)2.91748219
121plasma lipoprotein particle assembly (GO:0034377)2.90702576
122L-ascorbic acid metabolic process (GO:0019852)2.89963252
123alpha-amino acid catabolic process (GO:1901606)2.89494319
124regulation of keratinocyte differentiation (GO:0045616)2.88402576
125hepatocyte apoptotic process (GO:0097284)2.88038379
126carnitine metabolic process (GO:0009437)2.87835372
127bile acid and bile salt transport (GO:0015721)2.87811193
128cholesterol efflux (GO:0033344)2.87634905
129branching involved in mammary gland duct morphogenesis (GO:0060444)2.84909900
130regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.84815286
131nucleobase-containing small molecule interconversion (GO:0015949)2.82632451
132regulation of hair follicle development (GO:0051797)2.81750887
133cholesterol homeostasis (GO:0042632)2.81525732
134negative regulation of fatty acid biosynthetic process (GO:0045717)2.81408691
135regulation of epidermis development (GO:0045682)2.80471808
136arginine metabolic process (GO:0006525)2.80108394
137regulation of cell proliferation involved in kidney development (GO:1901722)2.78886714
138negative regulation of protein activation cascade (GO:2000258)2.78758727
139one-carbon metabolic process (GO:0006730)2.78256583
140protein-lipid complex assembly (GO:0065005)2.77333661
141sterol homeostasis (GO:0055092)2.77282934
142planar cell polarity pathway involved in neural tube closure (GO:0090179)2.77247465
143tetrahydrofolate metabolic process (GO:0046653)2.76910537
144retinal metabolic process (GO:0042574)2.76377549
145drug transmembrane transport (GO:0006855)2.76333955
146glutamate metabolic process (GO:0006536)2.75595185
147negative regulation of cell size (GO:0045792)2.74991600
148regulation of cardioblast differentiation (GO:0051890)2.74838287
149negative regulation of hemostasis (GO:1900047)2.74616456
150negative regulation of blood coagulation (GO:0030195)2.74616456
151regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.74557664
152polarized epithelial cell differentiation (GO:0030859)2.74259566
153ectoderm development (GO:0007398)2.72607123
154negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.72018238
155molting cycle (GO:0042303)2.71942087
156hair cycle (GO:0042633)2.71942087
157negative regulation of cell fate specification (GO:0009996)2.70340975
158amyloid precursor protein metabolic process (GO:0042982)2.67280506
159type B pancreatic cell proliferation (GO:0044342)2.66708894
160prostanoid biosynthetic process (GO:0046457)2.66651720
161prostaglandin biosynthetic process (GO:0001516)2.66651720
162regulation of keratinocyte proliferation (GO:0010837)2.65197077
163regulation of apoptotic process involved in morphogenesis (GO:1902337)2.64413864
164tight junction assembly (GO:0070830)2.64185989
165regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.64099843
166regulation of translational fidelity (GO:0006450)2.62923162
167regulation of epidermal cell differentiation (GO:0045604)2.62598515
168epidermal cell differentiation (GO:0009913)2.62163220
169establishment of apical/basal cell polarity (GO:0035089)2.61727236
170negative regulation of stem cell proliferation (GO:2000647)2.59185262
171NADPH regeneration (GO:0006740)2.56465334
172epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55416626
173norepinephrine metabolic process (GO:0042415)2.54320389
174regulation of mammary gland epithelial cell proliferation (GO:0033599)2.52281522
175endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.51794018
176regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.51459224
177chemical homeostasis within a tissue (GO:0048875)2.50170688
178cytoskeletal anchoring at plasma membrane (GO:0007016)2.49263940
179peptide cross-linking (GO:0018149)2.48923770
180cell adhesion mediated by integrin (GO:0033627)2.48681237
181regulation of cholesterol biosynthetic process (GO:0045540)2.48269127
182* focal adhesion assembly (GO:0048041)2.45336496
183* cell-substrate adherens junction assembly (GO:0007045)2.45336496
184cardiac right ventricle morphogenesis (GO:0003215)2.44900108
185endothelial cell chemotaxis (GO:0035767)2.44381272
186regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.43954529
187regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.43624576
188cell-cell junction assembly (GO:0007043)2.43485135
189mammary gland epithelial cell proliferation (GO:0033598)2.43011956
190morphogenesis of embryonic epithelium (GO:0016331)2.42813726
191response to water (GO:0009415)2.41769719
192protein localization to endosome (GO:0036010)2.40471028
193* adherens junction assembly (GO:0034333)2.39492252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.31210066
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.16076901
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.10980452
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.97538470
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.58700170
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.94559103
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.79156779
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.77434635
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.68913961
10* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.21146067
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.96130121
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.56555503
13CLOCK_20551151_ChIP-Seq_293T_Human2.54657119
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43789659
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.33052422
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19556383
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.15262014
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12218920
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.01756441
20ZNF263_19887448_ChIP-Seq_K562_Human2.00940001
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.97965674
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.97768534
23* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.88681090
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85876314
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77225430
26CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.76575155
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74152380
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.69332738
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65019556
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59044402
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58435043
32* RUNX1_27514584_Chip-Seq_MCF-7_Human1.57320876
33* ATF3_27146783_Chip-Seq_COLON_Human1.53015978
34* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51652594
35* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51652594
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49233573
37KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46427809
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45256276
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43764522
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43512178
41RACK7_27058665_Chip-Seq_MCF-7_Human1.43095134
42* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41692851
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40241369
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39098968
45* TET1_21451524_ChIP-Seq_MESCs_Mouse1.38133916
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.37812118
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34253003
48P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33741767
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32070856
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31994315
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31799227
52CDX2_20551321_ChIP-Seq_CACO-2_Human1.30711942
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29482484
54MYC_18555785_ChIP-Seq_MESCs_Mouse1.28740221
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28457278
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27821370
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26456976
58SOX2_20726797_ChIP-Seq_SW620_Human1.25026400
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23581113
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.23155106
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22991212
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22596357
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20194640
64SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20091612
65* SMC4_20622854_ChIP-Seq_HELA_Human1.19693674
66* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19579369
67* GATA4_25053715_ChIP-Seq_YYC3_Human1.17216580
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.16757358
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15775325
70* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15434221
71TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15402628
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13926348
73DCP1A_22483619_ChIP-Seq_HELA_Human1.13909594
74TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13528675
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11856199
76XRN2_22483619_ChIP-Seq_HELA_Human1.11840481
77TP63_22573176_ChIP-Seq_HFKS_Human1.11350407
78* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09526818
79* P68_20966046_ChIP-Seq_HELA_Human1.09060220
80LXR_22292898_ChIP-Seq_THP-1_Human1.08944136
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07401450
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06995812
83ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05781051
84* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05267780
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.04891154
86MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04625131
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04470151
88* GATA6_25053715_ChIP-Seq_YYC3_Human1.04079274
89* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03275862
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03124402
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03057959
92* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02829866
93KLF5_25053715_ChIP-Seq_YYC3_Human1.02559219
94ELF5_23300383_ChIP-Seq_T47D_Human0.99638461
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99363314
96VDR_21846776_ChIP-Seq_THP-1_Human0.98880132
97* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97873001
98* TP53_20018659_ChIP-ChIP_R1E_Mouse0.96486620
99CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95245871
100CHD1_26751641_Chip-Seq_LNCaP_Human0.95139980
101EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94757664
102* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94404332
103* CREB1_26743006_Chip-Seq_LNCaP_Human0.93068825
104CJUN_26792858_Chip-Seq_BT549_Human0.92782187
105FOXM1_23109430_ChIP-Seq_U2OS_Human0.92640229
106MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92565083
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92431387
108ELK1_22589737_ChIP-Seq_MCF10A_Human0.92371798
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92009486
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91665908
111SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91078644
112* UBF1/2_26484160_Chip-Seq_HMECs_Human0.90986902
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86044641
114SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85740257
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85638737
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85391173
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85391173
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83316246
119* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82700107
120NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82079471
121RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81174437
122JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80882709
123AR_21909140_ChIP-Seq_LNCAP_Human0.80599407
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80529172
125BRD4_25478319_ChIP-Seq_HGPS_Human0.78822358
126TP53_22127205_ChIP-Seq_IMR90_Human0.78571244
127JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78233840
128HNF4A_19822575_ChIP-Seq_HepG2_Human0.76297077
129* SA1_27219007_Chip-Seq_ERYTHROID_Human0.74253210
130KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.74004871
131KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.74004871
132KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74004871
133E2F1_18555785_ChIP-Seq_MESCs_Mouse0.73870400
134* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.73806059
135* GATA3_24758297_ChIP-Seq_MCF-7_Human0.71463659
136SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70062737
137SMC1_22415368_ChIP-Seq_MEFs_Mouse0.69652801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.22098668
2MP0002139_abnormal_hepatobiliary_system4.82032535
3MP0003705_abnormal_hypodermis_morpholog3.91745210
4MP0005085_abnormal_gallbladder_physiolo3.86457862
5MP0008875_abnormal_xenobiotic_pharmacok3.64364496
6MP0005365_abnormal_bile_salt3.33181136
7MP0003806_abnormal_nucleotide_metabolis3.11044215
8MP0008438_abnormal_cutaneous_collagen3.02559903
9MP0003252_abnormal_bile_duct2.77267204
10MP0010678_abnormal_skin_adnexa2.71218475
11MP0005275_abnormal_skin_tensile2.65808035
12MP0010030_abnormal_orbit_morphology2.52466832
13MP0004264_abnormal_extraembryonic_tissu2.47648545
14MP0009840_abnormal_foam_cell2.29509557
15MP0002796_impaired_skin_barrier2.29165727
16MP0000383_abnormal_hair_follicle2.20589109
17MP0010329_abnormal_lipoprotein_level2.10419144
18MP0009053_abnormal_anal_canal2.07307955
19MP0004381_abnormal_hair_follicle1.94467737
20MP0000566_synostosis1.92610519
21MP0003941_abnormal_skin_development1.92164319
22MP0002060_abnormal_skin_morphology1.91466266
23MP0009780_abnormal_chondrocyte_physiolo1.83519077
24MP0000537_abnormal_urethra_morphology1.80442405
25MP0000678_abnormal_parathyroid_gland1.77244529
26MP0001849_ear_inflammation1.76681579
27MP0005332_abnormal_amino_acid1.75877988
28MP0005023_abnormal_wound_healing1.68120139
29MP0010368_abnormal_lymphatic_system1.67201318
30MP0010352_gastrointestinal_tract_polyps1.66240067
31MP0009384_cardiac_valve_regurgitation1.64459254
32MP0004019_abnormal_vitamin_homeostasis1.63658052
33MP0005501_abnormal_skin_physiology1.62775570
34MP0005451_abnormal_body_composition1.62270374
35MP0005503_abnormal_tendon_morphology1.61178899
36MP0001666_abnormal_nutrient_absorption1.59794943
37MP0010234_abnormal_vibrissa_follicle1.56932398
38MP0005409_darkened_coat_color1.53971179
39MP0005083_abnormal_biliary_tract1.53102226
40MP0003195_calcinosis1.50995433
41MP0002138_abnormal_hepatobiliary_system1.48339767
42MP0004233_abnormal_muscle_weight1.47292756
43MP0003453_abnormal_keratinocyte_physiol1.46835344
44MP0003566_abnormal_cell_adhesion1.43439657
45MP0002234_abnormal_pharynx_morphology1.41140219
46MP0003186_abnormal_redox_activity1.39629329
47MP0003279_aneurysm1.38430231
48MP0005248_abnormal_Harderian_gland1.37817403
49MP0009379_abnormal_foot_pigmentation1.33470992
50MP0000627_abnormal_mammary_gland1.33080439
51MP0003315_abnormal_perineum_morphology1.32139927
52MP0004272_abnormal_basement_membrane1.32099173
53MP0003191_abnormal_cellular_cholesterol1.27663619
54MP0001661_extended_life_span1.25969860
55MP0003011_delayed_dark_adaptation1.25799491
56MP0002877_abnormal_melanocyte_morpholog1.23686270
57MP0000462_abnormal_digestive_system1.23355367
58MP0000609_abnormal_liver_physiology1.22200614
59MP0008260_abnormal_autophagy1.21774775
60MP0001542_abnormal_bone_strength1.20214913
61MP0004782_abnormal_surfactant_physiolog1.16790775
62MP0000003_abnormal_adipose_tissue1.16330902
63MP0005319_abnormal_enzyme/_coenzyme1.15843576
64MP0000427_abnormal_hair_cycle1.12613333
65MP0001216_abnormal_epidermal_layer1.09413446
66MP0002098_abnormal_vibrissa_morphology1.08422842
67MP0001958_emphysema1.06612601
68MP0005508_abnormal_skeleton_morphology1.05957325
69MP0009250_abnormal_appendicular_skeleto1.05028357
70MP0002118_abnormal_lipid_homeostasis1.04344473
71MP0000762_abnormal_tongue_morphology1.03875270
72MP0001243_abnormal_dermal_layer1.03323436
73MP0002295_abnormal_pulmonary_circulatio1.02773686
74MP0002249_abnormal_larynx_morphology0.99128315
75MP0005257_abnormal_intraocular_pressure0.97251298
76MP0009697_abnormal_copulation0.96325773
77MP0005084_abnormal_gallbladder_morpholo0.96122596
78MP0000377_abnormal_hair_follicle0.96076148
79MP0002254_reproductive_system_inflammat0.94289102
80MP0010771_integument_phenotype0.94213084
81MP0000579_abnormal_nail_morphology0.94011121
82MP0002282_abnormal_trachea_morphology0.93832020
83MP0003942_abnormal_urinary_system0.92204919
84MP0003123_paternal_imprinting0.91948211
85MP0000367_abnormal_coat/_hair0.90994367
86MP0001881_abnormal_mammary_gland0.90832145
87MP0003385_abnormal_body_wall0.90754689
88MP0000858_altered_metastatic_potential0.89285581
89MP0001879_abnormal_lymphatic_vessel0.86149740
90MP0000163_abnormal_cartilage_morphology0.82488789
91MP0002089_abnormal_postnatal_growth/wei0.82397913
92MP0009643_abnormal_urine_homeostasis0.81249208
93MP0003693_abnormal_embryo_hatching0.81010019
94MP0004858_abnormal_nervous_system0.80883056
95MP0005375_adipose_tissue_phenotype0.80393613
96MP0000538_abnormal_urinary_bladder0.79554520
97MP0000598_abnormal_liver_morphology0.79346828
98MP0000467_abnormal_esophagus_morphology0.78945297
99MP0005623_abnormal_meninges_morphology0.76441354
100MP0000013_abnormal_adipose_tissue0.76261679
101MP0005058_abnormal_lysosome_morphology0.75722283
102MP0005330_cardiomyopathy0.75587939
103MP0006054_spinal_hemorrhage0.75466242
104MP0002896_abnormal_bone_mineralization0.74424188
105MP0002111_abnormal_tail_morphology0.71050519
106MP0004957_abnormal_blastocyst_morpholog0.70181890
107MP0005666_abnormal_adipose_tissue0.69707667
108MP0001340_abnormal_eyelid_morphology0.69210552
109MP0004185_abnormal_adipocyte_glucose0.69206590
110MP0000767_abnormal_smooth_muscle0.66716014
111MP0000647_abnormal_sebaceous_gland0.66446158
112MP0009931_abnormal_skin_appearance0.66430301
113MP0002115_abnormal_skeleton_extremities0.65018256
114MP0004947_skin_inflammation0.63992906
115MP0000750_abnormal_muscle_regeneration0.63867915
116MP0001191_abnormal_skin_condition0.62456870
117MP0005076_abnormal_cell_differentiation0.61990365
118MP0005220_abnormal_exocrine_pancreas0.61596751
119MP0005395_other_phenotype0.60664962
120MP0002932_abnormal_joint_morphology0.60554325
121MP0000733_abnormal_muscle_development0.60054730
122MP0002168_other_aberrant_phenotype0.59802126
123MP0005408_hypopigmentation0.58952832
124MP0003786_premature_aging0.57927976
125MP0001915_intracranial_hemorrhage0.57804186
126MP0002233_abnormal_nose_morphology0.57558399
127MP0003638_abnormal_response/metabolism_0.57530675
128MP0005390_skeleton_phenotype0.57055263
129MP0001348_abnormal_lacrimal_gland0.56430851
130MP0004197_abnormal_fetal_growth/weight/0.56252390
131MP0002697_abnormal_eye_size0.56062844
132MP0006138_congestive_heart_failure0.55770712
133MP0001727_abnormal_embryo_implantation0.55434661
134MP0003755_abnormal_palate_morphology0.55234720
135MP0003950_abnormal_plasma_membrane0.54669899
136MP0000751_myopathy0.54616902
137MP0001764_abnormal_homeostasis0.53960677
138MP0005197_abnormal_uvea_morphology0.53810875
139MP0000358_abnormal_cell_content/0.53674242
140MP0003115_abnormal_respiratory_system0.53209167
141MP0008932_abnormal_embryonic_tissue0.52897213
142MP0002135_abnormal_kidney_morphology0.52269969
143MP0005584_abnormal_enzyme/coenzyme_acti0.51723606
144MP0003091_abnormal_cell_migration0.51587077
145MP0005193_abnormal_anterior_eye0.50601013
146MP0000613_abnormal_salivary_gland0.49987875
147MP0009672_abnormal_birth_weight0.49366181
148MP0002086_abnormal_extraembryonic_tissu0.48617525

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)5.66909178
2Fragile nails (HP:0001808)5.23540893
3Intrahepatic cholestasis (HP:0001406)5.09889533
4Deep venous thrombosis (HP:0002625)5.01583674
5Milia (HP:0001056)4.77786240
6Plantar hyperkeratosis (HP:0007556)4.74399154
7Premature rupture of membranes (HP:0001788)4.71071111
8Xanthomatosis (HP:0000991)4.67601688
9Abnormality of monocarboxylic acid metabolism (HP:0010996)4.60290640
10Protrusio acetabuli (HP:0003179)4.57662084
11Hypobetalipoproteinemia (HP:0003563)4.47467272
12Abnormality of aromatic amino acid family metabolism (HP:0004338)4.17079614
13Pili torti (HP:0003777)4.08964075
14Nail dystrophy (HP:0008404)4.04991804
15Alopecia of scalp (HP:0002293)3.94490695
16Palmoplantar hyperkeratosis (HP:0000972)3.80405191
17Prolonged partial thromboplastin time (HP:0003645)3.70353886
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.69146105
19Hypolipoproteinemia (HP:0010981)3.67239569
20Thick nail (HP:0001805)3.66390094
21Hypotrichosis (HP:0001006)3.64432036
22Palmar hyperkeratosis (HP:0010765)3.48501486
23Abnormal hair laboratory examination (HP:0003328)3.44493764
24Ridged nail (HP:0001807)3.40248349
25Hypoalphalipoproteinemia (HP:0003233)3.37376964
26Abnormal hemoglobin (HP:0011902)3.35527539
27Right ventricular cardiomyopathy (HP:0011663)3.29752615
28Selective tooth agenesis (HP:0001592)3.15757854
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.12455248
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.09481095
31Sparse eyelashes (HP:0000653)3.06962596
32Hyperlipoproteinemia (HP:0010980)3.02047457
33Fat malabsorption (HP:0002630)3.00036211
34Complement deficiency (HP:0004431)2.98068544
35Abnormality of the common coagulation pathway (HP:0010990)2.94152925
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.85615563
37Epidermoid cyst (HP:0200040)2.83558604
38Abnormality of complement system (HP:0005339)2.76154993
39Abnormality of methionine metabolism (HP:0010901)2.76082790
40Hyperammonemia (HP:0001987)2.75669651
41Septate vagina (HP:0001153)2.75050702
42Short nail (HP:0001799)2.73603452
43Oral leukoplakia (HP:0002745)2.71962476
44Lip pit (HP:0100267)2.70990584
45Myocardial infarction (HP:0001658)2.68170922
46Abnormal blistering of the skin (HP:0008066)2.65838607
47Hyperglycinuria (HP:0003108)2.60542861
48Peritonitis (HP:0002586)2.60039798
49Hydroxyprolinuria (HP:0003080)2.58931890
50Abnormality of proline metabolism (HP:0010907)2.58931890
51Malnutrition (HP:0004395)2.57113032
52Micronodular cirrhosis (HP:0001413)2.52400403
53Cardiovascular calcification (HP:0011915)2.47530813
54Hepatocellular carcinoma (HP:0001402)2.47165570
55Abnormality of pyrimidine metabolism (HP:0004353)2.45417268
56Hyperglycinemia (HP:0002154)2.44514348
57Abnormality of serine family amino acid metabolism (HP:0010894)2.44419804
58Abnormality of glycine metabolism (HP:0010895)2.44419804
59Vascular calcification (HP:0004934)2.43498540
60Abnormality of the Achilles tendon (HP:0005109)2.41220662
61Joint hemorrhage (HP:0005261)2.40076925
62Erythema (HP:0010783)2.40003762
63Onycholysis (HP:0001806)2.39183626
64Ventricular tachycardia (HP:0004756)2.37854982
65Hypophosphatemic rickets (HP:0004912)2.37341534
66Neonatal short-limb short stature (HP:0008921)2.36803105
67Abnormality of the intrinsic pathway (HP:0010989)2.36794635
68Biconcave vertebral bodies (HP:0004586)2.36264129
69Hypercholesterolemia (HP:0003124)2.36197427
70Natal tooth (HP:0000695)2.35226891
71Vertebral compression fractures (HP:0002953)2.34992132
72Congenital ichthyosiform erythroderma (HP:0007431)2.33586688
73Abnormal cartilage morphology (HP:0002763)2.32699650
74Turricephaly (HP:0000262)2.31999203
75Abnormal delivery (HP:0001787)2.30728264
76Soft skin (HP:0000977)2.30608590
77Hypokinesia (HP:0002375)2.30117879
78Spinal cord compression (HP:0002176)2.29281780
79Concave nail (HP:0001598)2.28658273
80Hypoplasia of dental enamel (HP:0006297)2.28092572
81Flat acetabular roof (HP:0003180)2.22873530
82Sparse scalp hair (HP:0002209)2.22611050
83Distal lower limb amyotrophy (HP:0008944)2.20460444
84Blue sclerae (HP:0000592)2.18324993
85Abnormality of the umbilical cord (HP:0010881)2.17975613
86Dry hair (HP:0011359)2.17244081
87Distal lower limb muscle weakness (HP:0009053)2.15862590
88Mildly elevated creatine phosphokinase (HP:0008180)2.15833664
89Amelogenesis imperfecta (HP:0000705)2.15274648
90Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.15145453
91Reduced subcutaneous adipose tissue (HP:0003758)2.13387393
92Hypoglycemic coma (HP:0001325)2.13383068
93Testicular atrophy (HP:0000029)2.11882256
94Aplasia cutis congenita (HP:0001057)2.11855474
95Hyperacusis (HP:0010780)2.09566562
96Atrophic scars (HP:0001075)2.09161174
97Broad face (HP:0000283)2.08571330
98Steatorrhea (HP:0002570)2.06639392
99Skin nodule (HP:0200036)2.05560937
100Rickets (HP:0002748)2.05356347
101Abnormality of nucleobase metabolism (HP:0010932)2.03368735
102Achilles tendon contracture (HP:0001771)2.00210950
103Elbow flexion contracture (HP:0002987)1.99549392
104Palmoplantar keratoderma (HP:0000982)1.98437905
105Fatigable weakness (HP:0003473)1.98282193
106Abnormality of the neuromuscular junction (HP:0003398)1.98282193
107Rough bone trabeculation (HP:0100670)1.96418957
108Osteolytic defects of the phalanges of the hand (HP:0009771)1.95825152
109Osteolytic defects of the hand bones (HP:0009699)1.95825152
110Fragile skin (HP:0001030)1.95135279
111Ketosis (HP:0001946)1.94197188
112Coxa vara (HP:0002812)1.94129688
113Aortic dissection (HP:0002647)1.93739915
114Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92881228
115Dicarboxylic aciduria (HP:0003215)1.92881228
116Abnormal tarsal ossification (HP:0008369)1.92028751
117Abnormality of placental membranes (HP:0011409)1.91670433
118Amniotic constriction ring (HP:0009775)1.91670433
119Hyperparathyroidism (HP:0000843)1.90791733
120Acanthosis nigricans (HP:0000956)1.89215912
121Entropion (HP:0000621)1.88995631
122Woolly hair (HP:0002224)1.88034640
123Advanced eruption of teeth (HP:0006288)1.88014079
124Abnormality of fatty-acid metabolism (HP:0004359)1.87947689
125Absent eyelashes (HP:0000561)1.86466768
126Coronal craniosynostosis (HP:0004440)1.85812202
127Distal upper limb amyotrophy (HP:0007149)1.85615416
128Upper limb amyotrophy (HP:0009129)1.85615416
129Brittle hair (HP:0002299)1.85359629
130Cupped ribs (HP:0000887)1.84498431
131Microvesicular hepatic steatosis (HP:0001414)1.84472286
132Wormian bones (HP:0002645)1.84313628
133Ankyloglossia (HP:0010296)1.84275198
134Thin bony cortex (HP:0002753)1.83159967
135Abnormality of the distal phalanges of the toes (HP:0010182)1.83056656
136Corneal erosion (HP:0200020)1.82700918
137Abnormality of purine metabolism (HP:0004352)1.82344468
138Esophageal varix (HP:0002040)1.81520770
139Abdominal distention (HP:0003270)1.80788654
140Back pain (HP:0003418)1.78957013
141Abnormality of the gastric mucosa (HP:0004295)1.78325962
142Sparse lateral eyebrow (HP:0005338)1.77217156
143Hyporeflexia of lower limbs (HP:0002600)1.75804243
144Abnormality of the salivary glands (HP:0010286)1.75698753
145Increased connective tissue (HP:0009025)1.75603219
146Cervical subluxation (HP:0003308)1.75020461
147Ectropion (HP:0000656)1.74369001
148Ileus (HP:0002595)1.74213380
149Nonimmune hydrops fetalis (HP:0001790)1.73816050
150Microglossia (HP:0000171)1.73525091
151Popliteal pterygium (HP:0009756)1.73258592
152Neonatal death (HP:0003811)1.72965230
153Genu recurvatum (HP:0002816)1.72536296
154Pterygium (HP:0001059)1.70823508
155Anonychia (HP:0001798)1.70635185
156Spastic diplegia (HP:0001264)1.69585471
157Poikiloderma (HP:0001029)1.69183697
158Knee flexion contracture (HP:0006380)1.68075299
159Abnormalities of placenta or umbilical cord (HP:0001194)1.67784233
160Shallow orbits (HP:0000586)1.67368382
161Trismus (HP:0000211)1.67361427
162Increased mean platelet volume (HP:0011877)1.67227884
163Generalized amyotrophy (HP:0003700)1.67099243
164Delayed CNS myelination (HP:0002188)1.66537542
165Abnormality of serum amino acid levels (HP:0003112)1.66396515
166Overgrowth (HP:0001548)1.66289815
167Oligodontia (HP:0000677)1.66174029
168Stroke (HP:0001297)1.65964555
169J-shaped sella turcica (HP:0002680)1.65529993
170Axonal loss (HP:0003447)1.65307656
171Diaphragmatic weakness (HP:0009113)1.65075808
172Curly hair (HP:0002212)1.64778270
173Abnormality of carpal bone ossification (HP:0006257)1.64316561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.15992979
2EPHA23.14863361
3ERN13.06500277
4LATS22.91952325
5MUSK2.70330335
6PIM22.69763579
7STK38L2.66508344
8ARAF2.64639556
9TRIB32.61280166
10BCKDK2.51388800
11IRAK32.36660886
12EPHB22.32604929
13MAP3K32.27193120
14MST1R2.22388042
15SIK12.19414681
16RPS6KB22.18011856
17SMG12.16384903
18LATS12.16156327
19EIF2AK12.06353989
20DDR22.01640027
21MAP3K121.99580783
22TESK11.94804375
23MAPKAPK31.90247989
24TAOK21.72815785
25PTK61.68025986
26MAP3K111.65764467
27VRK21.64619099
28SCYL21.63023960
29FER1.61944298
30PKN21.53243257
31RPS6KA41.52420797
32PINK11.48390472
33FGFR41.46652406
34MOS1.45973807
35NEK91.44977962
36ERBB41.44527039
37NME11.44181936
38LRRK21.41261856
39BMX1.41151632
40TTN1.34535187
41MET1.33959971
42KDR1.33619346
43ABL21.27325291
44MAP2K31.26894574
45BUB11.24659640
46MYLK1.23857323
47PIK3CG1.22745277
48LMTK21.20561168
49PAK21.19020857
50LIMK11.17726525
51PTK21.15878766
52MAP3K91.15109479
53DYRK1B1.14875242
54CDK61.14621480
55MAP2K11.09718285
56TLK11.06662335
57STK101.05572056
58BRAF1.04559179
59PDGFRA0.95330810
60PAK40.94689482
61STK30.94159523
62TESK20.91733403
63ILK0.90426210
64MAP2K20.89803813
65NTRK10.89561933
66MAP3K20.89544740
67CAMK2G0.88996291
68MAP3K80.88520927
69DAPK30.86396960
70RIPK10.86043970
71STK240.80766267
72MAP3K100.80618184
73MAPK110.80300281
74MAPK70.80059549
75EPHB10.79564269
76ICK0.78359283
77MST40.77587462
78TGFBR20.76664452
79PRKD20.74954991
80RPS6KL10.70154684
81RPS6KC10.70154684
82PAK30.69757268
83FRK0.69467742
84FGFR10.67192904
85TGFBR10.66983157
86IRAK20.66749151
87MTOR0.65263853
88STK380.63999604
89ERBB20.62362012
90RPS6KA60.61459929
91EIF2AK30.58755590
92FLT30.57506391
93CAMK2B0.54861086
94PAK10.53438832
95PRKG20.52347223
96PIM10.52329000
97RPS6KA20.52092391
98ROCK10.50741334
99TBK10.47044691
100AURKA0.46997357
101TRPM70.46207732
102CDK120.46034667
103MAP3K50.45739385
104NEK10.45050690
105GRK60.44715702
106CAMK2D0.44442005
107NEK60.44045940
108MAP3K10.43551369
109PDPK10.43083890
110EIF2AK20.42651818
111CDK40.42344836
112PRKD10.41004478
113AKT20.39377511
114PRPF4B0.39093937
115MAP3K60.38799705
116BRSK10.38463734
117CDK70.38377306
118RAF10.37785844
119MAP3K70.37739417
120CDK80.37331190
121PRKD30.36661959
122DAPK10.36565427
123AURKB0.36191542
124SIK30.35968800
125CDK90.35125588
126STK160.33840111
127NUAK10.31893900
128ROCK20.31302972
129KSR20.31168604
130EPHA30.31092550
131PTK2B0.30469601
132PBK0.29969520
133GSK3A0.29784906
134PRKCI0.29657553
135CHUK0.27326773
136EEF2K0.27223345
137IKBKB0.25658100
138INSR0.25168918
139MAPKAPK20.24860724
140DMPK0.24847854
141TAOK10.24203933
142CASK0.23593085
143ABL10.23536778

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.16701400
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.70798509
3Pentose and glucuronate interconversions_Homo sapiens_hsa000403.12713776
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.56258527
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.54850202
6Chemical carcinogenesis_Homo sapiens_hsa052042.47879975
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43843840
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36828603
9Complement and coagulation cascades_Homo sapiens_hsa046102.33778366
10Arginine biosynthesis_Homo sapiens_hsa002202.31092926
11Nitrogen metabolism_Homo sapiens_hsa009102.28001596
12Retinol metabolism_Homo sapiens_hsa008302.18943296
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14576205
14Drug metabolism - other enzymes_Homo sapiens_hsa009832.14280300
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.11265877
16Tryptophan metabolism_Homo sapiens_hsa003802.05959508
17Fatty acid degradation_Homo sapiens_hsa000712.00328189
18Caffeine metabolism_Homo sapiens_hsa002321.86824767
19Thyroid cancer_Homo sapiens_hsa052161.78114034
20One carbon pool by folate_Homo sapiens_hsa006701.68859475
21Starch and sucrose metabolism_Homo sapiens_hsa005001.66087208
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.66018065
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64601781
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64208103
25PPAR signaling pathway_Homo sapiens_hsa033201.60225069
26Peroxisome_Homo sapiens_hsa041461.58227837
27Folate biosynthesis_Homo sapiens_hsa007901.55279981
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55207441
29Butanoate metabolism_Homo sapiens_hsa006501.54846469
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50801308
31Histidine metabolism_Homo sapiens_hsa003401.48287459
32Glutathione metabolism_Homo sapiens_hsa004801.47169869
33Vibrio cholerae infection_Homo sapiens_hsa051101.45821514
34Sulfur metabolism_Homo sapiens_hsa009201.44062945
35Fat digestion and absorption_Homo sapiens_hsa049751.44002412
36N-Glycan biosynthesis_Homo sapiens_hsa005101.39714512
37Biosynthesis of amino acids_Homo sapiens_hsa012301.37574133
38Selenocompound metabolism_Homo sapiens_hsa004501.37381614
39Sulfur relay system_Homo sapiens_hsa041221.37342878
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37294932
41Phenylalanine metabolism_Homo sapiens_hsa003601.37181509
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33547969
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31080185
44Ribosome_Homo sapiens_hsa030101.25002596
45Fatty acid metabolism_Homo sapiens_hsa012121.24449043
46Propanoate metabolism_Homo sapiens_hsa006401.20209796
47beta-Alanine metabolism_Homo sapiens_hsa004101.20179266
48Carbon metabolism_Homo sapiens_hsa012001.19025718
49Tyrosine metabolism_Homo sapiens_hsa003501.17935929
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.16432341
51Steroid biosynthesis_Homo sapiens_hsa001001.16007645
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14543761
53Vitamin digestion and absorption_Homo sapiens_hsa049771.13051630
54Other glycan degradation_Homo sapiens_hsa005111.11721877
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.09409402
56Bile secretion_Homo sapiens_hsa049761.07839544
57Pyrimidine metabolism_Homo sapiens_hsa002401.06437704
58Staphylococcus aureus infection_Homo sapiens_hsa051501.05531583
59Arginine and proline metabolism_Homo sapiens_hsa003301.04385732
60Sphingolipid metabolism_Homo sapiens_hsa006001.03678197
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00571872
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98617918
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97092747
64Bladder cancer_Homo sapiens_hsa052190.94761885
65Chronic myeloid leukemia_Homo sapiens_hsa052200.93340897
66Insulin signaling pathway_Homo sapiens_hsa049100.92944198
67Pyruvate metabolism_Homo sapiens_hsa006200.90811486
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86099496
69Endometrial cancer_Homo sapiens_hsa052130.85853825
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85315766
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83880622
72ErbB signaling pathway_Homo sapiens_hsa040120.79702307
73Base excision repair_Homo sapiens_hsa034100.76686115
74ABC transporters_Homo sapiens_hsa020100.73425941
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68485171
76Fatty acid elongation_Homo sapiens_hsa000620.68378118
77VEGF signaling pathway_Homo sapiens_hsa043700.67206372
78AMPK signaling pathway_Homo sapiens_hsa041520.67200008
79ECM-receptor interaction_Homo sapiens_hsa045120.66648241
80Nucleotide excision repair_Homo sapiens_hsa034200.66067036
81Acute myeloid leukemia_Homo sapiens_hsa052210.65775319
82Hepatitis C_Homo sapiens_hsa051600.64814645
83Galactose metabolism_Homo sapiens_hsa000520.64667082
84Notch signaling pathway_Homo sapiens_hsa043300.63179842
85Pentose phosphate pathway_Homo sapiens_hsa000300.61742907
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61181070
87DNA replication_Homo sapiens_hsa030300.61034200
88Renal cell carcinoma_Homo sapiens_hsa052110.60993554
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60336367
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58870316
91Pancreatic cancer_Homo sapiens_hsa052120.58372404
92Oxidative phosphorylation_Homo sapiens_hsa001900.57712925
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57147144
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55792115
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54911367
96Dilated cardiomyopathy_Homo sapiens_hsa054140.54387530
97Alzheimers disease_Homo sapiens_hsa050100.54099545
98Endocytosis_Homo sapiens_hsa041440.53500954
99Lysine degradation_Homo sapiens_hsa003100.52593741
100Huntingtons disease_Homo sapiens_hsa050160.52511689
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52395358
102Shigellosis_Homo sapiens_hsa051310.52010321
103Insulin resistance_Homo sapiens_hsa049310.49797956
104Basal cell carcinoma_Homo sapiens_hsa052170.48946979
105Proteoglycans in cancer_Homo sapiens_hsa052050.48370322
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47365471
107Fructose and mannose metabolism_Homo sapiens_hsa000510.47136990
108p53 signaling pathway_Homo sapiens_hsa041150.46914325
109Glioma_Homo sapiens_hsa052140.46200198
110Non-small cell lung cancer_Homo sapiens_hsa052230.46062590
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45835966
112Proteasome_Homo sapiens_hsa030500.43884498
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43762771
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43235671
115Metabolic pathways_Homo sapiens_hsa011000.39759785
116Adherens junction_Homo sapiens_hsa045200.38199042
117Arachidonic acid metabolism_Homo sapiens_hsa005900.37512120
118Focal adhesion_Homo sapiens_hsa045100.37482372
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37334037
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35624272
121Hippo signaling pathway_Homo sapiens_hsa043900.35212320
122TGF-beta signaling pathway_Homo sapiens_hsa043500.34684956
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.33510248
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.33380365
125Hedgehog signaling pathway_Homo sapiens_hsa043400.33288603
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32343885
127Glycerolipid metabolism_Homo sapiens_hsa005610.31786647
128Small cell lung cancer_Homo sapiens_hsa052220.30679323
129Amoebiasis_Homo sapiens_hsa051460.30412328
130Melanoma_Homo sapiens_hsa052180.26295855
131Protein digestion and absorption_Homo sapiens_hsa049740.24901045
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22419616
133Tight junction_Homo sapiens_hsa045300.20456772
134Linoleic acid metabolism_Homo sapiens_hsa005910.19825204
135Mineral absorption_Homo sapiens_hsa049780.19087751
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16474585
137Prion diseases_Homo sapiens_hsa050200.16442243
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15375563
139Vitamin B6 metabolism_Homo sapiens_hsa007500.15027207
140MicroRNAs in cancer_Homo sapiens_hsa052060.14787864
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13954754
142Prostate cancer_Homo sapiens_hsa052150.13578233
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.13110191

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