RHOF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.39975941
2negative regulation of cell killing (GO:0031342)6.75224859
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.75224859
4negative thymic T cell selection (GO:0045060)5.80897441
5negative T cell selection (GO:0043383)5.79168921
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.75838584
7regulation of gamma-delta T cell differentiation (GO:0045586)5.75205007
8regulation of isotype switching to IgG isotypes (GO:0048302)5.58475973
9cellular response to interleukin-15 (GO:0071350)5.58049002
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.50764322
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.50764322
12response to interleukin-15 (GO:0070672)5.50057492
13regulation of gamma-delta T cell activation (GO:0046643)5.42478418
14antigen processing and presentation of endogenous antigen (GO:0019883)5.30259002
15positive thymic T cell selection (GO:0045059)5.21101082
16regulation of B cell receptor signaling pathway (GO:0050855)4.94538153
17regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.92643892
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.78846358
19thymic T cell selection (GO:0045061)4.71827999
20positive T cell selection (GO:0043368)4.64799084
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.56923178
22T cell selection (GO:0045058)4.41130409
23interferon-gamma production (GO:0032609)4.40878504
24regulation of regulatory T cell differentiation (GO:0045589)4.35001972
25leukocyte aggregation (GO:0070486)4.12541434
26T cell migration (GO:0072678)4.06718696
27positive regulation of isotype switching (GO:0045830)4.02135853
28regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.01372384
29regulation of alpha-beta T cell proliferation (GO:0046640)3.99305620
30positive regulation of humoral immune response (GO:0002922)3.98713899
31lymphocyte costimulation (GO:0031294)3.97505151
32T cell costimulation (GO:0031295)3.97432439
33positive regulation of alpha-beta T cell proliferation (GO:0046641)3.91234212
34regulation of interleukin-12 biosynthetic process (GO:0045075)3.89860937
35B cell receptor signaling pathway (GO:0050853)3.85871892
36neutrophil activation involved in immune response (GO:0002283)3.85822430
37mature B cell differentiation (GO:0002335)3.82356160
38T cell receptor signaling pathway (GO:0050852)3.82068183
39negative regulation of T cell mediated immunity (GO:0002710)3.79196378
40regulation of natural killer cell mediated immunity (GO:0002715)3.78206348
41regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.78206348
42positive regulation of natural killer cell mediated immunity (GO:0002717)3.73916487
43positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.73916487
44positive regulation of B cell mediated immunity (GO:0002714)3.72006314
45positive regulation of immunoglobulin mediated immune response (GO:0002891)3.72006314
46antigen receptor-mediated signaling pathway (GO:0050851)3.69729016
47regulation of T cell receptor signaling pathway (GO:0050856)3.68618998
48regulation of T cell tolerance induction (GO:0002664)3.67347124
49positive regulation of DNA recombination (GO:0045911)3.67300460
50immunoglobulin mediated immune response (GO:0016064)3.63272815
51regulation of B cell differentiation (GO:0045577)3.57735695
52regulation of isotype switching (GO:0045191)3.57267033
53mast cell activation (GO:0045576)3.54753979
54antigen processing and presentation via MHC class Ib (GO:0002475)3.52786705
55T cell homeostasis (GO:0043029)3.50821987
56positive regulation of interleukin-2 production (GO:0032743)3.49185673
57regulation of immunoglobulin mediated immune response (GO:0002889)3.46767176
58regulation of B cell mediated immunity (GO:0002712)3.45877135
59regulation of leukocyte mediated cytotoxicity (GO:0001910)3.38737578
60NIK/NF-kappaB signaling (GO:0038061)3.37705479
61negative regulation of lymphocyte mediated immunity (GO:0002707)3.35734096
62tolerance induction (GO:0002507)3.35522625
63myeloid dendritic cell activation (GO:0001773)3.35126576
64positive regulation of T cell mediated cytotoxicity (GO:0001916)3.33524193
65myeloid dendritic cell differentiation (GO:0043011)3.31004475
66positive regulation of tolerance induction (GO:0002645)3.30867319
67regulation of interleukin-2 biosynthetic process (GO:0045076)3.29983784
68cytidine deamination (GO:0009972)3.24465801
69cytidine metabolic process (GO:0046087)3.24465801
70cytidine catabolic process (GO:0006216)3.24465801
71negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.23175244
72regulation of T-helper 1 cell differentiation (GO:0045625)3.22931226
73neutrophil activation (GO:0042119)3.21441815
74defense response to protozoan (GO:0042832)3.20934929
75regulation of tolerance induction (GO:0002643)3.20515500
76granulocyte activation (GO:0036230)3.20209874
77positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.19093863
78G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.18019319
79Peyers patch development (GO:0048541)3.17919012
80mucosal-associated lymphoid tissue development (GO:0048537)3.17919012
81mature B cell differentiation involved in immune response (GO:0002313)3.17474839
82negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.17212136
83natural killer cell activation (GO:0030101)3.16569408
84positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.16227813
85interferon-gamma-mediated signaling pathway (GO:0060333)3.14561208
86response to peptidoglycan (GO:0032494)3.14426181
87positive regulation of B cell differentiation (GO:0045579)3.13649970
88mast cell degranulation (GO:0043303)3.12868469
89mast cell activation involved in immune response (GO:0002279)3.12868469
90B cell mediated immunity (GO:0019724)3.10922934
91leukocyte degranulation (GO:0043299)3.10205696
92response to protozoan (GO:0001562)3.10081151
93regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.09395783
94negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.08751905
95regulation of T cell mediated cytotoxicity (GO:0001914)3.07986009
96positive regulation of immunoglobulin production (GO:0002639)3.07923365
97negative regulation of interleukin-12 production (GO:0032695)3.07569952
98negative regulation of erythrocyte differentiation (GO:0045647)3.07458750
99CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.06620480
100regulation of cell killing (GO:0031341)3.05716150
101positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.01567928
102negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.01095549
103lymph node development (GO:0048535)3.00902216
104negative regulation of T cell receptor signaling pathway (GO:0050860)3.00743751
105regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.98839741
106response to type I interferon (GO:0034340)2.96273811
107type I interferon signaling pathway (GO:0060337)2.95188372
108cellular response to type I interferon (GO:0071357)2.95188372
109positive regulation of granulocyte differentiation (GO:0030854)2.94911725
110JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.94869373
111regulation of immunoglobulin production (GO:0002637)2.93998984
112negative regulation of T-helper cell differentiation (GO:0045623)2.93679560
113negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.93679560
114dendritic cell chemotaxis (GO:0002407)2.93670572
115negative regulation of adaptive immune response (GO:0002820)2.93329854
116response to muramyl dipeptide (GO:0032495)2.91842592
117Arp2/3 complex-mediated actin nucleation (GO:0034314)2.91650930
118regulation of chronic inflammatory response (GO:0002676)2.91473509
119positive regulation of cell killing (GO:0031343)2.90303287
120myeloid cell activation involved in immune response (GO:0002275)2.88534601
121positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87382324
122pyrimidine ribonucleoside catabolic process (GO:0046133)2.87010896
123positive regulation of interleukin-17 production (GO:0032740)2.86026445
124negative regulation of innate immune response (GO:0045824)2.85090982
125negative regulation of T cell apoptotic process (GO:0070233)2.84084946
126detection of bacterium (GO:0016045)2.81519351
127regulation of interferon-beta biosynthetic process (GO:0045357)2.79102382
128positive regulation of defense response to virus by host (GO:0002230)2.78377276
129positive regulation by organism of defense response of other organism involved in symbiotic interact2.77173777
130modulation by symbiont of host immune response (GO:0052553)2.77173777
131positive regulation by symbiont of host defense response (GO:0052509)2.77173777
132modulation by symbiont of host defense response (GO:0052031)2.77173777
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.77173777
134modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.77173777
135negative regulation of leukocyte mediated immunity (GO:0002704)2.76085794
136regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73305569
137regulation of alpha-beta T cell activation (GO:0046634)2.72370883
138detection of other organism (GO:0098543)2.70296436

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.03838354
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.64594701
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.87319995
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.17559644
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.75448445
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.41399598
7STAT4_19710469_ChIP-ChIP_TH1__Mouse3.40637241
8* MYC_22102868_ChIP-Seq_BL_Human3.40032980
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.37628886
10RUNX_20019798_ChIP-Seq_JUKART_Human3.35769590
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.22129644
12* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.15138158
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.08941397
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.08683628
15MYB_26560356_Chip-Seq_TH2_Human2.91624576
16* MAF_26560356_Chip-Seq_TH1_Human2.87614500
17SCL_19346495_ChIP-Seq_HPC-7_Human2.68899769
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.56190281
19VDR_21846776_ChIP-Seq_THP-1_Human2.51284616
20* UTX_26944678_Chip-Seq_JUKART_Human2.45803538
21* MYB_26560356_Chip-Seq_TH1_Human2.44343021
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.26727001
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26509294
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26247398
25* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.24102984
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.20627186
27SPI1_23547873_ChIP-Seq_NB4_Human2.18176931
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17488491
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12644963
30* TCF7_22412390_ChIP-Seq_EML_Mouse2.11024127
31* RUNX1_22412390_ChIP-Seq_EML_Mouse2.08961218
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04846125
33MAF_26560356_Chip-Seq_TH2_Human1.98574997
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.96688445
35VDR_24763502_ChIP-Seq_THP-1_Human1.96387843
36* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.90316137
37GATA3_27048872_Chip-Seq_THYMUS_Human1.88844626
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.87622154
39* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87513474
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86455507
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81773268
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.80976942
43SPI1_23127762_ChIP-Seq_K562_Human1.80151221
44* KDM2B_26808549_Chip-Seq_DND41_Human1.79322045
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79004427
46* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76171018
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76129243
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74952593
49* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74568840
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67903134
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63897139
52* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58633609
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57443086
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48723452
55BCOR_27268052_Chip-Seq_Bcells_Human1.44671618
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40699171
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39636405
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37709423
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37165213
60* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36753300
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35363345
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32363640
63P68_20966046_ChIP-Seq_HELA_Human1.32259112
64* GATA1_19941827_ChIP-Seq_MEL_Mouse1.31585687
65GATA3_26560356_Chip-Seq_TH2_Human1.28284196
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25027369
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25007084
68* ELK3_25401928_ChIP-Seq_HUVEC_Human1.23941687
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22616845
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21157633
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20093066
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19847837
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19589628
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17119150
75* KDM2B_26808549_Chip-Seq_JURKAT_Human1.15777503
76PU_27001747_Chip-Seq_BMDM_Mouse1.13445812
77NCOR1_26117541_ChIP-Seq_K562_Human1.12022281
78* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09018377
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08877595
80* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08774965
81SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.08491665
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08474582
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07883191
84* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07382169
85E2F1_20622854_ChIP-Seq_HELA_Human1.05719087
86BCL6_27268052_Chip-Seq_Bcells_Human1.04727128
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03767185
88* RACK7_27058665_Chip-Seq_MCF-7_Human1.02314538
89LXR_22292898_ChIP-Seq_THP-1_Human1.01880401
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01467166
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00779652
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99860040
93* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99706348
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98658347
95CIITA_25753668_ChIP-Seq_RAJI_Human0.98578880
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98031891
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.97969238
98SPI1_20517297_ChIP-Seq_HL60_Human0.97804966
99* CTCF_21964334_Chip-Seq_Bcells_Human0.96938878
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95984919
101DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95625672
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.95036147
103GATA1_22025678_ChIP-Seq_K562_Human0.94669444
104PHF8_20622854_ChIP-Seq_HELA_Human0.94493761
105FOXP3_21729870_ChIP-Seq_TREG_Human0.93708352
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93529513
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92435254
108VDR_23849224_ChIP-Seq_CD4+_Human0.89202610
109* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85487089
110ELF1_20517297_ChIP-Seq_JURKAT_Human0.82156385
111GATA2_19941826_ChIP-Seq_K562_Human0.81294152
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81202370
113CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81023717
114HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80295939
115NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.79662678
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78464871
117P300_27268052_Chip-Seq_Bcells_Human0.77935866
118CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77705426
119* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77058222
120RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74870486
121GATA1_19941826_ChIP-Seq_K562_Human0.73436038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.38294800
2MP0001835_abnormal_antigen_presentation3.91057796
3MP0003763_abnormal_thymus_physiology3.89766088
4MP0000685_abnormal_immune_system3.79353256
5MP0001800_abnormal_humoral_immune3.30732493
6MP0001790_abnormal_immune_system3.29220796
7MP0005387_immune_system_phenotype3.29220796
8MP0009785_altered_susceptibility_to3.21988391
9MP0005000_abnormal_immune_tolerance2.97306373
10MP0002723_abnormal_immune_serum2.82944201
11MP0002420_abnormal_adaptive_immunity2.80746196
12MP0001819_abnormal_immune_cell2.78752877
13MP0002452_abnormal_antigen_presenting2.75499140
14MP0002398_abnormal_bone_marrow2.68590378
15MP0004510_myositis2.64399785
16MP0005025_abnormal_response_to2.57190156
17MP0003866_abnormal_defecation2.55102963
18MP0003436_decreased_susceptibility_to2.50436361
19MP0002148_abnormal_hypersensitivity_rea2.40407064
20MP0001873_stomach_inflammation2.37850980
21MP0003303_peritoneal_inflammation2.35086064
22MP0000716_abnormal_immune_system2.35039664
23MP0002166_altered_tumor_susceptibility2.24516252
24MP0006082_CNS_inflammation2.21730698
25MP0002405_respiratory_system_inflammati2.16684043
26MP0004859_abnormal_synaptic_plasticity2.09013899
27MP0002722_abnormal_immune_system2.08526573
28MP0000689_abnormal_spleen_morphology2.08326982
29MP0010155_abnormal_intestine_physiology2.05839568
30MP0009333_abnormal_splenocyte_physiolog2.05457015
31MP0002419_abnormal_innate_immunity1.96539156
32MP0000703_abnormal_thymus_morphology1.93940772
33MP0003806_abnormal_nucleotide_metabolis1.91843225
34MP0005464_abnormal_platelet_physiology1.91585700
35MP0002429_abnormal_blood_cell1.90677085
36MP0002006_tumorigenesis1.90414391
37MP0002396_abnormal_hematopoietic_system1.82527968
38MP0005310_abnormal_salivary_gland1.77201414
39MP0004947_skin_inflammation1.76033463
40MP0004808_abnormal_hematopoietic_stem1.63558212
41MP0001845_abnormal_inflammatory_respons1.62588485
42MP0001853_heart_inflammation1.56252155
43MP0003300_gastrointestinal_ulcer1.54740086
44MP0003880_abnormal_central_pattern1.53082057
45MP0005451_abnormal_body_composition1.47390056
46MP0009840_abnormal_foam_cell1.44424068
47MP0003724_increased_susceptibility_to1.43621633
48MP0002138_abnormal_hepatobiliary_system1.35694789
49MP0005058_abnormal_lysosome_morphology1.35693666
50MP0002933_joint_inflammation1.32400828
51MP0000465_gastrointestinal_hemorrhage1.25524578
52MP0003191_abnormal_cellular_cholesterol1.21298648
53MP0000490_abnormal_crypts_of1.18831128
54MP0001545_abnormal_hematopoietic_system1.18022764
55MP0005397_hematopoietic_system_phenotyp1.18022764
56MP0005174_abnormal_tail_pigmentation1.14983709
57MP0008569_lethality_at_weaning1.12085977
58MP0003635_abnormal_synaptic_transmissio1.11417726
59MP0001348_abnormal_lacrimal_gland1.11060618
60MP0005083_abnormal_biliary_tract1.09279230
61MP0004381_abnormal_hair_follicle1.05896837
62MP0001501_abnormal_sleep_pattern1.05793054
63MP0008469_abnormal_protein_level1.03651801
64MP0000858_altered_metastatic_potential0.98841518
65MP0003453_abnormal_keratinocyte_physiol0.98399484
66MP0001663_abnormal_digestive_system0.96071021
67MP0002139_abnormal_hepatobiliary_system0.94708704
68MP0001533_abnormal_skeleton_physiology0.94680059
69MP0008004_abnormal_stomach_pH0.94644139
70MP0009745_abnormal_behavioral_response0.93626571
71MP0003172_abnormal_lysosome_physiology0.93141204
72MP0003448_altered_tumor_morphology0.91763837
73MP0009763_increased_sensitivity_to0.89772210
74MP0000343_altered_response_to0.89193499
75MP0001851_eye_inflammation0.87357788
76MP0002009_preneoplasia0.87171035
77MP0005075_abnormal_melanosome_morpholog0.85567170
78MP0005166_decreased_susceptibility_to0.83793886
79MP0002064_seizures0.81754639
80MP0001986_abnormal_taste_sensitivity0.81403192
81MP0000604_amyloidosis0.80561545
82MP0005423_abnormal_somatic_nervous0.78954116
83MP0001968_abnormal_touch/_nociception0.78056845
84MP0002019_abnormal_tumor_incidence0.78027402
85MP0000015_abnormal_ear_pigmentation0.76964142
86MP0010234_abnormal_vibrissa_follicle0.73600222
87MP0003656_abnormal_erythrocyte_physiolo0.73565210
88MP0008260_abnormal_autophagy0.72695222
89MP0002063_abnormal_learning/memory/cond0.71560164
90MP0008961_abnormal_basal_metabolism0.71557201
91MP0008874_decreased_physiological_sensi0.69775915
92MP0002998_abnormal_bone_remodeling0.67723397
93MP0002822_catalepsy0.67718179
94MP0009764_decreased_sensitivity_to0.67510590
95MP0000249_abnormal_blood_vessel0.66480163
96MP0003828_pulmonary_edema0.66404956
97MP0003329_amyloid_beta_deposits0.64844604
98MP0002095_abnormal_skin_pigmentation0.64839568
99MP0005584_abnormal_enzyme/coenzyme_acti0.64082582
100MP0003045_fibrosis0.63833472
101MP0000609_abnormal_liver_physiology0.63368964
102MP0002132_abnormal_respiratory_system0.62458348
103MP0008872_abnormal_physiological_respon0.61101009
104MP0001765_abnormal_ion_homeostasis0.60953955
105MP0002735_abnormal_chemical_nociception0.60643733
106MP0002277_abnormal_respiratory_mucosa0.60428516
107MP0002136_abnormal_kidney_physiology0.59034399
108MP0004185_abnormal_adipocyte_glucose0.58463145
109MP0009643_abnormal_urine_homeostasis0.58341354
110MP0002572_abnormal_emotion/affect_behav0.57704772
111MP0009765_abnormal_xenobiotic_induced0.57011024
112MP0002736_abnormal_nociception_after0.56917152
113MP0005410_abnormal_fertilization0.55721129
114MP0008873_increased_physiological_sensi0.55600100
115MP0005390_skeleton_phenotype0.55541622
116MP0003075_altered_response_to0.55493276
117MP0003795_abnormal_bone_structure0.53269543
118MP0008875_abnormal_xenobiotic_pharmacok0.53162968
119MP0005167_abnormal_blood-brain_barrier0.52827186
120MP0001919_abnormal_reproductive_system0.52599434
121MP0003879_abnormal_hair_cell0.52166883
122MP0003183_abnormal_peptide_metabolism0.51430401
123MP0002909_abnormal_adrenal_gland0.51307622
124MP0002733_abnormal_thermal_nociception0.49322888
125MP0001970_abnormal_pain_threshold0.47800548
126MP0002083_premature_death0.46541445
127MP0002272_abnormal_nervous_system0.45755941
128MP0004270_analgesia0.45482690
129MP0009278_abnormal_bone_marrow0.44866938
130MP0000477_abnormal_intestine_morphology0.44638370
131MP0003943_abnormal_hepatobiliary_system0.44452246
132MP0002693_abnormal_pancreas_physiology0.44348167

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bronchitis (HP:0002837)5.01128845
2T lymphocytopenia (HP:0005403)4.99158945
3Abnormality of T cell number (HP:0011839)4.86970752
4IgM deficiency (HP:0002850)4.72643883
5Chronic otitis media (HP:0000389)4.66073206
6Elevated erythrocyte sedimentation rate (HP:0003565)4.65475769
7Stomatitis (HP:0010280)4.56162251
8Myositis (HP:0100614)4.54332076
9Nasal polyposis (HP:0100582)4.28186279
10Recurrent fungal infections (HP:0002841)4.19173064
11Abnormality of T cells (HP:0002843)4.16314707
12Agammaglobulinemia (HP:0004432)4.09635799
13Panhypogammaglobulinemia (HP:0003139)3.94474153
14Eczematoid dermatitis (HP:0000976)3.93179091
15Recurrent viral infections (HP:0004429)3.85203660
16Retrobulbar optic neuritis (HP:0100654)3.76688367
17Optic neuritis (HP:0100653)3.76688367
18IgG deficiency (HP:0004315)3.76607372
19Abnormality of the nasal mucosa (HP:0000433)3.75569828
20Recurrent cutaneous fungal infections (HP:0011370)3.75257848
21Chronic mucocutaneous candidiasis (HP:0002728)3.75257848
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.72483542
23Severe combined immunodeficiency (HP:0004430)3.69656576
24Recurrent abscess formation (HP:0002722)3.62230887
25Thrombocytosis (HP:0001894)3.51694271
26Lymphopenia (HP:0001888)3.48779894
27Meningitis (HP:0001287)3.43723116
28Vasculitis (HP:0002633)3.39268172
29Combined immunodeficiency (HP:0005387)3.36790599
30Orchitis (HP:0100796)3.35945191
31Thyroiditis (HP:0100646)3.34963720
32Abnormality of cells of the lymphoid lineage (HP:0012140)3.34336234
33Autoimmune hemolytic anemia (HP:0001890)3.34199450
34Gastrointestinal stroma tumor (HP:0100723)3.24523512
35Abnormality of T cell physiology (HP:0011840)3.13445444
36Recurrent sinusitis (HP:0011108)3.08837172
37Chronic sinusitis (HP:0011109)3.05473017
38Fatigue (HP:0012378)3.01453301
39Mediastinal lymphadenopathy (HP:0100721)3.01096052
40Recurrent bacterial skin infections (HP:0005406)3.00701145
41B lymphocytopenia (HP:0010976)2.96744083
42Abnormality of B cell number (HP:0010975)2.96744083
43Increased IgM level (HP:0003496)2.95443696
44Recurrent skin infections (HP:0001581)2.89421079
45Chronic diarrhea (HP:0002028)2.89023194
46Bronchitis (HP:0012387)2.87300320
47Gastrointestinal inflammation (HP:0004386)2.87237931
48Cellulitis (HP:0100658)2.86092122
49Inflammation of the large intestine (HP:0002037)2.83609627
50Autoimmune thrombocytopenia (HP:0001973)2.83321213
51Encephalitis (HP:0002383)2.76292879
52Abnormality of eosinophils (HP:0001879)2.76275098
53Prolonged bleeding time (HP:0003010)2.70607297
54Arterial thrombosis (HP:0004420)2.69534505
55Abnormality of macrophages (HP:0004311)2.66634838
56Pulmonary infiltrates (HP:0002113)2.66589852
57Increased serum ferritin (HP:0003281)2.66297994
58Increased IgE level (HP:0003212)2.65310919
59Obstructive lung disease (HP:0006536)2.63827690
60Chronic obstructive pulmonary disease (HP:0006510)2.63827690
61IgA deficiency (HP:0002720)2.63334297
62Progressive inability to walk (HP:0002505)2.61908055
63Leukocytosis (HP:0001974)2.59413948
64Hemoptysis (HP:0002105)2.57622026
65Joint swelling (HP:0001386)2.51809198
66Pustule (HP:0200039)2.51508684
67Papilloma (HP:0012740)2.50693444
68Verrucae (HP:0200043)2.50693444
69Colitis (HP:0002583)2.48853601
70Chest pain (HP:0100749)2.47043636
71Gastrointestinal infarctions (HP:0005244)2.41783024
72Epistaxis (HP:0000421)2.41775648
73Abnormality of glycolipid metabolism (HP:0010969)2.41655886
74Abnormality of liposaccharide metabolism (HP:0010968)2.41655886
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.41655886
76Keratoconjunctivitis sicca (HP:0001097)2.38903052
77Abnormality of binocular vision (HP:0011514)2.37288982
78Diplopia (HP:0000651)2.37288982
79Petechiae (HP:0000967)2.37129381
80Hypergammaglobulinemia (HP:0010702)2.35412922
81Lymphoma (HP:0002665)2.34224420
82Acute hepatic failure (HP:0006554)2.29042711
83Anorexia (HP:0002039)2.28766302
84Abnormality of iron homeostasis (HP:0011031)2.28257764
85Dyschromatopsia (HP:0007641)2.27084990
86Urticaria (HP:0001025)2.26522270
87Abnormal platelet volume (HP:0011876)2.24640051
88Hypertensive crisis (HP:0100735)2.23918906
89Hemorrhage of the eye (HP:0011885)2.22843309
90Interstitial pulmonary disease (HP:0006530)2.22114157
91Hepatosplenomegaly (HP:0001433)2.22071660
92Emphysema (HP:0002097)2.19905705
93Abnormality of the prostate (HP:0008775)2.19182535
94Recurrent gram-negative bacterial infections (HP:0005420)2.19087156
95Amaurosis fugax (HP:0100576)2.18499574
96Menorrhagia (HP:0000132)2.17546355
97Keratoconjunctivitis (HP:0001096)2.14038859
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12910420
99Eosinophilia (HP:0001880)2.03633456
100Dysostosis multiplex (HP:0000943)2.01433408
101Visual hallucinations (HP:0002367)2.00238433
102Abnormality of the fingertips (HP:0001211)1.97884911
103Increased cerebral lipofuscin (HP:0011813)1.96400008
104Gangrene (HP:0100758)1.96077898
105Vacuolated lymphocytes (HP:0001922)1.95477960
106Papilledema (HP:0001085)1.93676426
107Aplastic anemia (HP:0001915)1.93044820
108Increased muscle lipid content (HP:0009058)1.92568485
109Spontaneous hematomas (HP:0007420)1.91965219
110Impaired platelet aggregation (HP:0003540)1.90858963
111Abnormal platelet function (HP:0011869)1.90858963
112Joint hemorrhage (HP:0005261)1.90429885
113Focal motor seizures (HP:0011153)1.89572516
114Poikiloderma (HP:0001029)1.89470073
115Purpura (HP:0000979)1.88423762
116Hypochromic anemia (HP:0001931)1.87471617
117Abnormality of transition element cation homeostasis (HP:0011030)1.86852570
118Granulocytopenia (HP:0001913)1.86446485
119Restrictive lung disease (HP:0002091)1.85708672
120Basal cell carcinoma (HP:0002671)1.85321194
121Hypoplasia of the thymus (HP:0000778)1.84332711
122Gingival bleeding (HP:0000225)1.83983481
123Arthralgia (HP:0002829)1.83206215
124Amyotrophic lateral sclerosis (HP:0007354)1.83194787
125Recurrent otitis media (HP:0000403)1.82845025
126Sepsis (HP:0100806)1.79070867
127Bronchiectasis (HP:0002110)1.74550157

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.66177956
2TXK4.06093840
3JAK33.13476944
4ZAP702.66414570
5TAOK32.65098822
6MAP3K122.59841003
7MAP3K132.56109361
8IKBKE2.30112219
9GRK62.29128763
10RIPK42.25352324
11SYK2.19307485
12TBK12.13386792
13ITK2.05679643
14PRPF4B1.97348336
15MAP3K141.96103172
16TYK21.91013711
17FES1.88195140
18TAOK11.83652375
19ERN11.81168870
20BTK1.77858484
21BLK1.77681217
22MAP3K91.77521624
23JAK11.76583537
24EEF2K1.66650139
25KIT1.64788262
26TEC1.60409196
27LCK1.56096048
28IKBKB1.48489019
29SIK21.47561062
30STK101.44510170
31CDK191.42426515
32MST1R1.38236896
33RAF11.37530304
34HCK1.36779838
35MST41.36381374
36NLK1.31457613
37MAP3K31.29991758
38CSK1.26965146
39TNK21.23900899
40TLK11.22506150
41KSR21.20412567
42IRAK41.17918851
43NME21.14950018
44FGFR41.13929194
45ARAF1.11287811
46SMG11.09153242
47MAP2K31.06844629
48VRK21.06802671
49SIK31.04277909
50LRRK21.01112182
51MAP3K110.99470793
52EPHA20.97900788
53LYN0.96948598
54PRKCQ0.93679217
55PRKCH0.92163418
56PIM20.84478063
57KDR0.82501120
58GRK70.81482148
59NTRK30.80806832
60FGFR30.80005511
61SIK10.79650767
62MAP2K60.79381921
63DAPK10.79198301
64CHUK0.78096743
65CSF1R0.77086200
66MAPK110.76429351
67MAP2K70.76361058
68JAK20.75452726
69TESK20.74457254
70PIM10.74087288
71MAP3K100.74076548
72ALK0.73584979
73MAP3K70.73280171
74BMX0.72367889
75MAP3K10.69452157
76IRAK20.69135456
77TGFBR20.68831662
78CAMKK20.67962745
79PRKD20.67109590
80PDK10.65844845
81TNIK0.64098509
82CDK40.59786465
83CLK10.59042129
84MARK20.58927909
85PDPK10.56457548
86TGFBR10.56211848
87PKN20.54399886
88CAMKK10.52408589
89EPHB10.51137113
90MAP2K20.51133773
91BMPR20.50288367
92BCKDK0.49792111
93MUSK0.49473905
94MAPKAPK20.48841780
95MAPK150.48460480
96RET0.47571971
97MAP3K50.46909680
98FYN0.44066249
99MARK30.43763243
100MELK0.43418318
101MAPK120.43331768
102FGR0.40462997
103HIPK20.40112561
104TESK10.39369108
105STK240.38805759
106ADRBK20.38481738
107NTRK20.38318655
108PAK10.37535432
109CAMK10.37247913
110PAK40.36946625
111MAP3K40.36819184
112PRKG20.36502089
113MATK0.36314059
114SCYL20.36313164
115CDK50.33022427
116STK110.32886713
117MINK10.32662118
118MAPKAPK30.30895242
119GRK50.29250267
120PASK0.28784920
121ZAK0.27930138
122IRAK30.27647021
123CDK60.25850318
124PTK2B0.25403217
125KSR10.24977124
126PRKCD0.24218459
127MAPK40.21938841
128IRAK10.21937358
129TAOK20.21519162
130TRIB30.20931710
131DAPK30.20430005

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.15169032
2T cell receptor signaling pathway_Homo sapiens_hsa046602.77107179
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.73795145
4Graft-versus-host disease_Homo sapiens_hsa053322.64373445
5Allograft rejection_Homo sapiens_hsa053302.61027570
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.54657506
7B cell receptor signaling pathway_Homo sapiens_hsa046622.39370612
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.34963778
9Measles_Homo sapiens_hsa051622.09805964
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.00286414
11Leishmaniasis_Homo sapiens_hsa051401.97427161
12Antigen processing and presentation_Homo sapiens_hsa046121.83700411
13Hematopoietic cell lineage_Homo sapiens_hsa046401.82380600
14Osteoclast differentiation_Homo sapiens_hsa043801.81146764
15Staphylococcus aureus infection_Homo sapiens_hsa051501.76357476
16Autoimmune thyroid disease_Homo sapiens_hsa053201.69654840
17Type I diabetes mellitus_Homo sapiens_hsa049401.66383833
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62660594
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59344314
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.57279877
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50192965
22Chemokine signaling pathway_Homo sapiens_hsa040621.49172506
23Other glycan degradation_Homo sapiens_hsa005111.42824538
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39996133
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39605319
26Shigellosis_Homo sapiens_hsa051311.39225116
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33290083
28Asthma_Homo sapiens_hsa053101.30601105
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29993178
30Acute myeloid leukemia_Homo sapiens_hsa052211.29085951
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24995706
32TNF signaling pathway_Homo sapiens_hsa046681.15760784
33Toxoplasmosis_Homo sapiens_hsa051451.14113556
34Herpes simplex infection_Homo sapiens_hsa051681.13057925
35VEGF signaling pathway_Homo sapiens_hsa043701.12039269
36Ribosome_Homo sapiens_hsa030101.11851416
37Viral myocarditis_Homo sapiens_hsa054161.11800403
38Platelet activation_Homo sapiens_hsa046111.10454104
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.10361213
40Hepatitis B_Homo sapiens_hsa051611.07222328
41Tuberculosis_Homo sapiens_hsa051521.05228789
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.02415675
43Influenza A_Homo sapiens_hsa051641.02354204
44Long-term potentiation_Homo sapiens_hsa047201.00098925
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97068048
46Prolactin signaling pathway_Homo sapiens_hsa049170.95324331
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.95161210
48Systemic lupus erythematosus_Homo sapiens_hsa053220.92644828
49Salmonella infection_Homo sapiens_hsa051320.91462681
50Lysosome_Homo sapiens_hsa041420.89645738
51Olfactory transduction_Homo sapiens_hsa047400.88370733
52Apoptosis_Homo sapiens_hsa042100.87950810
53Rheumatoid arthritis_Homo sapiens_hsa053230.87902042
54Pancreatic cancer_Homo sapiens_hsa052120.86717780
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83939335
56Proteasome_Homo sapiens_hsa030500.83221124
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82122683
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81843409
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81470089
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79449393
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78177425
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77370379
63Epstein-Barr virus infection_Homo sapiens_hsa051690.76424276
64Pertussis_Homo sapiens_hsa051330.74799013
65Colorectal cancer_Homo sapiens_hsa052100.73583896
66Chronic myeloid leukemia_Homo sapiens_hsa052200.72532269
67Nicotine addiction_Homo sapiens_hsa050330.71328638
68Morphine addiction_Homo sapiens_hsa050320.70343515
69Malaria_Homo sapiens_hsa051440.68317575
70Fructose and mannose metabolism_Homo sapiens_hsa000510.68182125
71Legionellosis_Homo sapiens_hsa051340.67878774
72Hepatitis C_Homo sapiens_hsa051600.67089855
73Synaptic vesicle cycle_Homo sapiens_hsa047210.66913539
74African trypanosomiasis_Homo sapiens_hsa051430.65891526
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.65322625
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64715705
77HTLV-I infection_Homo sapiens_hsa051660.64612024
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64266867
79Salivary secretion_Homo sapiens_hsa049700.63351139
80Circadian entrainment_Homo sapiens_hsa047130.62866131
81MAPK signaling pathway_Homo sapiens_hsa040100.62352930
82Non-small cell lung cancer_Homo sapiens_hsa052230.61812028
83Phagosome_Homo sapiens_hsa041450.61474689
84Gastric acid secretion_Homo sapiens_hsa049710.60075432
85Cholinergic synapse_Homo sapiens_hsa047250.59692111
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58781897
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58530967
88Oxytocin signaling pathway_Homo sapiens_hsa049210.58330760
89Sulfur relay system_Homo sapiens_hsa041220.56259568
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56135806
91Endocytosis_Homo sapiens_hsa041440.55704119
92Glutamatergic synapse_Homo sapiens_hsa047240.55132297
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55013196
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54941174
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53374127
96Dopaminergic synapse_Homo sapiens_hsa047280.52075335
97Renin secretion_Homo sapiens_hsa049240.51905596
98GnRH signaling pathway_Homo sapiens_hsa049120.51425404
99Amphetamine addiction_Homo sapiens_hsa050310.48665711
100ErbB signaling pathway_Homo sapiens_hsa040120.48144745
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47025693
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.46376437
103Inositol phosphate metabolism_Homo sapiens_hsa005620.45161898
104GABAergic synapse_Homo sapiens_hsa047270.44902783
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43737709
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43279688
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42902084
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42804697
109Viral carcinogenesis_Homo sapiens_hsa052030.42802304
110Long-term depression_Homo sapiens_hsa047300.42216044
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.40131089
112Choline metabolism in cancer_Homo sapiens_hsa052310.40041415
113Calcium signaling pathway_Homo sapiens_hsa040200.39794260
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39338119
115Pentose phosphate pathway_Homo sapiens_hsa000300.35974131
116Pyrimidine metabolism_Homo sapiens_hsa002400.32022081
117Galactose metabolism_Homo sapiens_hsa000520.30648604
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.26965667
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26461512
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24630278
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24610844
122Insulin resistance_Homo sapiens_hsa049310.23975677
123Sphingolipid metabolism_Homo sapiens_hsa006000.21763993
124Arachidonic acid metabolism_Homo sapiens_hsa005900.16203934
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13127069
126Sulfur metabolism_Homo sapiens_hsa009200.12481292
127Bladder cancer_Homo sapiens_hsa052190.12204802
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.10272054
129FoxO signaling pathway_Homo sapiens_hsa040680.09631197

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