RHOG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.73443984
2leukocyte aggregation (GO:0070486)4.69474692
3detection of other organism (GO:0098543)4.39928837
4detection of bacterium (GO:0016045)4.35623641
5respiratory burst (GO:0045730)4.32263688
6immunoglobulin mediated immune response (GO:0016064)4.18792986
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.17479200
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.17479200
9neutrophil activation (GO:0042119)4.08756567
10response to peptidoglycan (GO:0032494)4.02094278
11modulation by symbiont of host defense response (GO:0052031)4.01512494
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.01512494
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.01512494
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.01512494
15modulation by symbiont of host immune response (GO:0052553)4.01512494
16positive regulation by symbiont of host defense response (GO:0052509)4.01512494
17antigen processing and presentation of endogenous antigen (GO:0019883)3.99291960
18positive regulation of gamma-delta T cell activation (GO:0046645)3.97938708
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97392386
20regulation of B cell receptor signaling pathway (GO:0050855)3.93864936
21granulocyte activation (GO:0036230)3.92043299
22mast cell activation (GO:0045576)3.78437087
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.70317069
24detection of external biotic stimulus (GO:0098581)3.65707248
25negative regulation of erythrocyte differentiation (GO:0045647)3.57566052
26Arp2/3 complex-mediated actin nucleation (GO:0034314)3.43747223
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.43245817
28response to muramyl dipeptide (GO:0032495)3.40772542
29myeloid cell activation involved in immune response (GO:0002275)3.40338005
30cellular extravasation (GO:0045123)3.38842060
31T cell migration (GO:0072678)3.36410208
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.33688918
33myeloid dendritic cell activation (GO:0001773)3.32045697
34defense response to protozoan (GO:0042832)3.31888265
35axon ensheathment in central nervous system (GO:0032291)3.30567184
36central nervous system myelination (GO:0022010)3.30567184
37amyloid precursor protein catabolic process (GO:0042987)3.29294778
38myeloid dendritic cell differentiation (GO:0043011)3.29020071
39regulation of T cell tolerance induction (GO:0002664)3.28824576
40response to interleukin-15 (GO:0070672)3.28080192
41negative regulation of T cell mediated immunity (GO:0002710)3.27801261
42detection of molecule of bacterial origin (GO:0032490)3.25513866
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.25398942
44regulation of mast cell activation involved in immune response (GO:0033006)3.24339329
45negative regulation of leukocyte mediated immunity (GO:0002704)3.23313110
46germinal center formation (GO:0002467)3.23195620
47negative regulation of cytokine production involved in immune response (GO:0002719)3.23014471
48negative regulation of phagocytosis (GO:0050765)3.21558871
49leukocyte degranulation (GO:0043299)3.20852528
50detection of biotic stimulus (GO:0009595)3.20650854
51positive regulation of antigen processing and presentation (GO:0002579)3.20016474
52regulation of myeloid leukocyte mediated immunity (GO:0002886)3.19299978
53B cell mediated immunity (GO:0019724)3.17003763
54regulation of interferon-beta biosynthetic process (GO:0045357)3.16529998
55positive regulation of B cell differentiation (GO:0045579)3.15213190
56leukocyte migration involved in inflammatory response (GO:0002523)3.12067531
57response to interferon-beta (GO:0035456)3.11823653
58response to protozoan (GO:0001562)3.11008702
59regulation of leukocyte degranulation (GO:0043300)3.09919715
60positive regulation of interleukin-17 production (GO:0032740)3.09403725
61type I interferon signaling pathway (GO:0060337)3.08819196
62cellular response to type I interferon (GO:0071357)3.08819196
63negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.07402472
64NIK/NF-kappaB signaling (GO:0038061)3.07181501
65response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.06560748
66response to host (GO:0075136)3.06560748
67response to host defenses (GO:0052200)3.06560748
68regulation of tolerance induction (GO:0002643)3.06088442
69regulation of B cell differentiation (GO:0045577)3.05868134
70response to type I interferon (GO:0034340)3.04485610
71lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04349812
72cellular response to interleukin-15 (GO:0071350)3.04301595
73cellular response to interferon-beta (GO:0035458)3.03959097
74positive regulation of interferon-alpha production (GO:0032727)3.01320459
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00979495
76neutrophil mediated immunity (GO:0002446)3.00356353
77B cell receptor signaling pathway (GO:0050853)3.00062814
78regulation of alpha-beta T cell proliferation (GO:0046640)2.98382763
79positive regulation of mast cell activation (GO:0033005)2.96035386
80cellular response to zinc ion (GO:0071294)2.95795759
81macrophage activation involved in immune response (GO:0002281)2.95508019
82tolerance induction (GO:0002507)2.94522138
83regulation of interferon-alpha production (GO:0032647)2.93871171
84macrophage activation (GO:0042116)2.93797394
85positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.92781740
86regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.91257207
87regulation of natural killer cell mediated immunity (GO:0002715)2.91257207
88microglial cell activation (GO:0001774)2.90719997
89regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.89513643
90positive thymic T cell selection (GO:0045059)2.87233303
91negative regulation of innate immune response (GO:0045824)2.85795042
92myeloid leukocyte activation (GO:0002274)2.85730690
93regulation of antigen processing and presentation (GO:0002577)2.84567979
94regulation of T cell mediated cytotoxicity (GO:0001914)2.83748928
95regulation of T-helper 2 cell differentiation (GO:0045628)2.83658478
96regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.83128941
97leukocyte cell-cell adhesion (GO:0007159)2.82400104
98response to fungus (GO:0009620)2.81669792
99negative regulation of interleukin-6 production (GO:0032715)2.78956143
100interferon-gamma-mediated signaling pathway (GO:0060333)2.78956134
101dendritic cell differentiation (GO:0097028)2.76573842
102regulation of gamma-delta T cell differentiation (GO:0045586)2.76341800
103positive regulation of T cell mediated cytotoxicity (GO:0001916)2.75462924
104antigen processing and presentation via MHC class Ib (GO:0002475)2.75454287
105negative regulation of alpha-beta T cell activation (GO:0046636)2.75233984
106regulation of mast cell degranulation (GO:0043304)2.75230190
107positive regulation of interleukin-10 production (GO:0032733)2.75028994
108modulation of growth of symbiont involved in interaction with host (GO:0044144)2.73902807
109regulation of growth of symbiont in host (GO:0044126)2.73902807
110negative regulation of growth of symbiont in host (GO:0044130)2.73902807
111negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.73902807
112regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.71490062
113positive regulation of mast cell activation involved in immune response (GO:0033008)2.70927016
114positive regulation of mast cell degranulation (GO:0043306)2.70927016
115leukocyte mediated cytotoxicity (GO:0001909)2.70785899
116pinocytosis (GO:0006907)2.70502447
117regulation of mast cell activation (GO:0033003)2.70454684
118T-helper 1 type immune response (GO:0042088)2.70237765
119amyloid precursor protein metabolic process (GO:0042982)2.70156021
120negative regulation of myeloid cell apoptotic process (GO:0033033)2.69677645
121regulation of interleukin-17 production (GO:0032660)2.66702278
122positive regulation of chemokine biosynthetic process (GO:0045080)2.64802771
123regulation of hypersensitivity (GO:0002883)2.64642851
124response to host immune response (GO:0052572)2.64216717
125response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.64216717
126negative regulation of interleukin-12 production (GO:0032695)2.63356933
127regulation of gamma-delta T cell activation (GO:0046643)2.63206352
128positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.63132540
129negative thymic T cell selection (GO:0045060)2.60356975
130regulation of lymphocyte migration (GO:2000401)2.60211043
131regulation of interleukin-12 biosynthetic process (GO:0045075)2.58050275
132regulation of chemokine biosynthetic process (GO:0045073)2.56352218
133regulation of dendritic cell antigen processing and presentation (GO:0002604)2.55403005
134negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.54913678
135negative regulation of cell killing (GO:0031342)2.54913678
136negative T cell selection (GO:0043383)2.53374591
137positive regulation of toll-like receptor signaling pathway (GO:0034123)2.51981726
138positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.51901355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.14927476
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.89560398
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.28638523
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.86384614
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.72260680
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.70918949
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.35199867
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.28273926
9* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.19317346
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.11218203
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06116370
12* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.05998880
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.96080022
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.80588311
15SCL_19346495_ChIP-Seq_HPC-7_Human2.68824100
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61185774
17* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.56811943
18* SPI1_23547873_ChIP-Seq_NB4_Human2.56216369
19VDR_21846776_ChIP-Seq_THP-1_Human2.54153826
20* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.52471520
21* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35762963
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.35274639
23VDR_24763502_ChIP-Seq_THP-1_Human2.30788436
24* MYB_26560356_Chip-Seq_TH2_Human2.19963976
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.18102615
26* MAF_26560356_Chip-Seq_TH1_Human2.08244484
27* RUNX1_22412390_ChIP-Seq_EML_Mouse2.07662154
28* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06644348
29RUNX_20019798_ChIP-Seq_JUKART_Human2.03829367
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.02510712
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.00804959
32E2F7_22180533_ChIP-Seq_HELA_Human1.99153376
33* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91602764
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91426661
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89709655
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87796736
37* MYB_26560356_Chip-Seq_TH1_Human1.76763562
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76318958
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73392510
40MYC_22102868_ChIP-Seq_BL_Human1.72736095
41* UTX_26944678_Chip-Seq_JUKART_Human1.68077832
42* SPI1_23127762_ChIP-Seq_K562_Human1.66340105
43LXR_22292898_ChIP-Seq_THP-1_Human1.64780202
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64093917
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58298030
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57128358
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55367199
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54100053
49GATA1_22383799_ChIP-Seq_G1ME_Mouse1.52212557
50* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51624328
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51404791
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49353093
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47914530
54PU_27001747_Chip-Seq_BMDM_Mouse1.46480457
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45340703
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45321955
57MAF_26560356_Chip-Seq_TH2_Human1.44007879
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39032467
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36469153
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35906448
61CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35111906
62* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33658880
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31133084
64* GATA3_27048872_Chip-Seq_THYMUS_Human1.28818819
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25362680
66* ELK3_25401928_ChIP-Seq_HUVEC_Human1.22470765
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20556743
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18774012
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18677150
70TCF7_22412390_ChIP-Seq_EML_Mouse1.18222270
71GATA1_22025678_ChIP-Seq_K562_Human1.16993591
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16928044
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14812070
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14568700
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.13824196
76NCOR1_26117541_ChIP-Seq_K562_Human1.12828630
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12524971
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.11964836
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11520084
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10269044
81VDR_24787735_ChIP-Seq_THP-1_Human1.08769132
82* GATA3_26560356_Chip-Seq_TH2_Human1.06919833
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.05520569
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05501458
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03173751
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02499100
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02364392
88* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99066867
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97479824
90EGR1_19032775_ChIP-ChIP_M12_Human0.97365502
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97320978
92KDM2B_26808549_Chip-Seq_JURKAT_Human0.96277229
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94324443
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93737627
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93056527
96* SA1_27219007_Chip-Seq_ERYTHROID_Human0.92777738
97STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92673182
98RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91679275
99RACK7_27058665_Chip-Seq_MCF-7_Human0.91307611
100TFEB_21752829_ChIP-Seq_HELA_Human0.90918083
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90840655
102SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89991881
103P68_20966046_ChIP-Seq_HELA_Human0.89970688
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.89901918
105* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88964203
106GABP_17652178_ChIP-ChIP_JURKAT_Human0.88746303
107STAT1_20625510_ChIP-Seq_HELA_Human0.88241261
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87390891
109VDR_23849224_ChIP-Seq_CD4+_Human0.86471041
110* SPI1_20517297_ChIP-Seq_HL60_Human0.84996843
111* GATA1_19941826_ChIP-Seq_K562_Human0.83996240
112* KDM2B_26808549_Chip-Seq_DND41_Human0.83872908
113KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82929217
114* BCL6_27268052_Chip-Seq_Bcells_Human0.79950021
115EST1_17652178_ChIP-ChIP_JURKAT_Human0.79285739
116CTCF_26484167_Chip-Seq_Bcells_Mouse0.78563772
117* BCOR_27268052_Chip-Seq_Bcells_Human0.78370005

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.05486786
2MP0009785_altered_susceptibility_to3.48737723
3MP0003436_decreased_susceptibility_to3.38099309
4MP0000685_abnormal_immune_system3.18751290
5MP0005671_abnormal_response_to3.16721562
6MP0002148_abnormal_hypersensitivity_rea3.15415443
7MP0005000_abnormal_immune_tolerance3.08147040
8MP0002419_abnormal_innate_immunity3.02847691
9MP0006082_CNS_inflammation2.98774152
10MP0005025_abnormal_response_to2.92653783
11MP0003303_peritoneal_inflammation2.88632433
12MP0001790_abnormal_immune_system2.87959750
13MP0005387_immune_system_phenotype2.87959750
14MP0005058_abnormal_lysosome_morphology2.78618069
15* MP0001800_abnormal_humoral_immune2.68515271
16* MP0002452_abnormal_antigen_presenting2.64104071
17MP0003724_increased_susceptibility_to2.63748627
18* MP0002723_abnormal_immune_serum2.61098495
19* MP0002420_abnormal_adaptive_immunity2.49235472
20* MP0001819_abnormal_immune_cell2.47857358
21MP0002405_respiratory_system_inflammati2.23084010
22MP0009333_abnormal_splenocyte_physiolog2.21548889
23MP0005464_abnormal_platelet_physiology2.20408917
24MP0000920_abnormal_myelination2.15209625
25MP0003763_abnormal_thymus_physiology2.13433692
26MP0009840_abnormal_foam_cell2.01290964
27* MP0002398_abnormal_bone_marrow1.98637113
28* MP0000716_abnormal_immune_system1.98328724
29MP0001533_abnormal_skeleton_physiology1.94275408
30MP0004510_myositis1.87610131
31MP0003172_abnormal_lysosome_physiology1.83086954
32MP0010155_abnormal_intestine_physiology1.82379013
33MP0002396_abnormal_hematopoietic_system1.79543068
34MP0001853_heart_inflammation1.78326992
35MP0001845_abnormal_inflammatory_respons1.78068263
36MP0002166_altered_tumor_susceptibility1.73038621
37MP0000689_abnormal_spleen_morphology1.72149250
38MP0004947_skin_inflammation1.68291793
39MP0000465_gastrointestinal_hemorrhage1.65978688
40* MP0002429_abnormal_blood_cell1.65313666
41MP0002722_abnormal_immune_system1.63775069
42MP0003191_abnormal_cellular_cholesterol1.61392870
43MP0000343_altered_response_to1.58877282
44MP0003806_abnormal_nucleotide_metabolis1.57555849
45MP0002933_joint_inflammation1.55829927
46MP0005310_abnormal_salivary_gland1.54014904
47MP0003300_gastrointestinal_ulcer1.53932953
48MP0002006_tumorigenesis1.49398712
49MP0008469_abnormal_protein_level1.48839574
50MP0001873_stomach_inflammation1.45101347
51MP0001851_eye_inflammation1.43332688
52MP0005397_hematopoietic_system_phenotyp1.39776013
53MP0001545_abnormal_hematopoietic_system1.39776013
54MP0003075_altered_response_to1.34035690
55MP0009278_abnormal_bone_marrow1.32701209
56MP0003690_abnormal_glial_cell1.27473855
57MP0003448_altered_tumor_morphology1.26995695
58MP0009764_decreased_sensitivity_to1.26572739
59MP0000858_altered_metastatic_potential1.24516875
60MP0003656_abnormal_erythrocyte_physiolo1.22830463
61MP0003866_abnormal_defecation1.16220512
62MP0000490_abnormal_crypts_of1.14701092
63MP0000703_abnormal_thymus_morphology1.13334489
64MP0003186_abnormal_redox_activity1.11437738
65MP0002998_abnormal_bone_remodeling1.10845380
66MP0005174_abnormal_tail_pigmentation1.07197976
67MP0000604_amyloidosis1.06438109
68MP0003183_abnormal_peptide_metabolism1.04979524
69MP0005075_abnormal_melanosome_morpholog1.03630523
70MP0002138_abnormal_hepatobiliary_system1.01756060
71MP0002277_abnormal_respiratory_mucosa1.01399049
72MP0008004_abnormal_stomach_pH1.01358426
73MP0004381_abnormal_hair_follicle0.98584952
74MP0004808_abnormal_hematopoietic_stem0.94945613
75MP0005451_abnormal_body_composition0.93340857
76MP0006054_spinal_hemorrhage0.88948404
77MP0004883_abnormal_blood_vessel0.88688668
78MP0005166_decreased_susceptibility_to0.86426958
79MP0000015_abnormal_ear_pigmentation0.86258672
80MP0008260_abnormal_autophagy0.85590104
81MP0009763_increased_sensitivity_to0.84168801
82MP0005390_skeleton_phenotype0.83249499
83MP0002132_abnormal_respiratory_system0.79467290
84MP0001663_abnormal_digestive_system0.78339051
85MP0005164_abnormal_response_to0.78016170
86MP0000249_abnormal_blood_vessel0.77646324
87MP0003950_abnormal_plasma_membrane0.76468199
88MP0003453_abnormal_keratinocyte_physiol0.74289606
89MP0002019_abnormal_tumor_incidence0.71653457
90MP0009765_abnormal_xenobiotic_induced0.71556286
91MP0002254_reproductive_system_inflammat0.68454500
92MP0005023_abnormal_wound_healing0.68350931
93MP0008874_decreased_physiological_sensi0.66712884
94MP0005409_darkened_coat_color0.66058256
95MP0003828_pulmonary_edema0.64190473
96MP0001348_abnormal_lacrimal_gland0.64076505
97MP0008873_increased_physiological_sensi0.63705936
98MP0003795_abnormal_bone_structure0.63346509
99MP0005319_abnormal_enzyme/_coenzyme0.60328216
100MP0002095_abnormal_skin_pigmentation0.58448274
101MP0002332_abnormal_exercise_endurance0.57082843
102MP0001542_abnormal_bone_strength0.56658060
103MP0008438_abnormal_cutaneous_collagen0.56632213
104MP0000609_abnormal_liver_physiology0.56329311
105MP0003045_fibrosis0.55923360
106MP0004782_abnormal_surfactant_physiolog0.55740277
107MP0005167_abnormal_blood-brain_barrier0.55012784
108MP0008057_abnormal_DNA_replication0.54881967
109MP0001958_emphysema0.53737241
110MP0005165_increased_susceptibility_to0.53295167
111MP0001243_abnormal_dermal_layer0.52949374
112MP0005584_abnormal_enzyme/coenzyme_acti0.52825530
113MP0005381_digestive/alimentary_phenotyp0.52682637
114MP0003091_abnormal_cell_migration0.51260865
115MP0003634_abnormal_glial_cell0.49863703

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.42329913
2Recurrent bacterial skin infections (HP:0005406)5.70142017
3Eczematoid dermatitis (HP:0000976)5.66771245
4Elevated erythrocyte sedimentation rate (HP:0003565)5.44394940
5Abnormality of macrophages (HP:0004311)4.53218410
6Stomatitis (HP:0010280)4.36681575
7Chronic otitis media (HP:0000389)4.36526916
8Myositis (HP:0100614)4.25105680
9Recurrent skin infections (HP:0001581)4.10940533
10Chronic obstructive pulmonary disease (HP:0006510)4.06651225
11Obstructive lung disease (HP:0006536)4.06651225
12Recurrent gram-negative bacterial infections (HP:0005420)3.79987197
13Vacuolated lymphocytes (HP:0001922)3.72377727
14Recurrent fungal infections (HP:0002841)3.72212209
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.68674281
16Mediastinal lymphadenopathy (HP:0100721)3.67906624
17Petechiae (HP:0000967)3.64774137
18Increased cerebral lipofuscin (HP:0011813)3.55189316
19Recurrent viral infections (HP:0004429)3.40706699
20Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.40496349
21Systemic lupus erythematosus (HP:0002725)3.35514549
22Cellulitis (HP:0100658)3.33757552
23Gastrointestinal infarctions (HP:0005244)3.28695791
24Encephalitis (HP:0002383)3.26194022
25Hepatosplenomegaly (HP:0001433)3.23767470
26Vasculitis (HP:0002633)3.18943735
27Axonal loss (HP:0003447)3.18586949
28Orchitis (HP:0100796)3.18170831
29Meningitis (HP:0001287)3.13195508
30Keratoconjunctivitis sicca (HP:0001097)3.09580276
31IgM deficiency (HP:0002850)3.09043218
32Autoimmune thrombocytopenia (HP:0001973)3.08174126
33Dysostosis multiplex (HP:0000943)3.07898929
34Spontaneous hematomas (HP:0007420)2.90591617
35Optic neuritis (HP:0100653)2.88589601
36Retrobulbar optic neuritis (HP:0100654)2.88589601
37Chronic mucocutaneous candidiasis (HP:0002728)2.86594672
38Recurrent cutaneous fungal infections (HP:0011370)2.86594672
39Abnormality of T cell number (HP:0011839)2.86587771
40Gingivitis (HP:0000230)2.86508625
41Keratoconjunctivitis (HP:0001096)2.82229645
42Pustule (HP:0200039)2.81806324
43Leukocytosis (HP:0001974)2.81146357
44Urticaria (HP:0001025)2.75670837
45Chest pain (HP:0100749)2.74790094
46Thrombocytosis (HP:0001894)2.74212393
47T lymphocytopenia (HP:0005403)2.71951423
48Interstitial pulmonary disease (HP:0006530)2.69798573
49Episodic fever (HP:0001954)2.60919751
50Recurrent bronchitis (HP:0002837)2.60732867
51Abnormality of T cells (HP:0002843)2.59672508
52Hypergammaglobulinemia (HP:0010702)2.58782519
53Panhypogammaglobulinemia (HP:0003139)2.58663270
54Amyloidosis (HP:0011034)2.58027284
55Eosinophilia (HP:0001880)2.57464851
56Abnormality of T cell physiology (HP:0011840)2.51776219
57Purpura (HP:0000979)2.48653613
58Hypochromic microcytic anemia (HP:0004840)2.47940258
59Parakeratosis (HP:0001036)2.46243110
60Abnormality of liposaccharide metabolism (HP:0010968)2.46215619
61Abnormality of glycosphingolipid metabolism (HP:0004343)2.46215619
62Abnormality of glycolipid metabolism (HP:0010969)2.46215619
63Hypochromic anemia (HP:0001931)2.46211493
64Anorexia (HP:0002039)2.44811174
65Inflammation of the large intestine (HP:0002037)2.43996022
66Severe combined immunodeficiency (HP:0004430)2.43875357
67Recurrent pneumonia (HP:0006532)2.42545780
68Abnormal delayed hypersensitivity skin test (HP:0002963)2.41556595
69Thyroiditis (HP:0100646)2.40113311
70Lymphopenia (HP:0001888)2.39540427
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.38901716
72Abnormality of iron homeostasis (HP:0011031)2.38140503
73Loss of speech (HP:0002371)2.37791840
74Nasal polyposis (HP:0100582)2.37512756
75Abnormality of eosinophils (HP:0001879)2.37434163
76Pulmonary infiltrates (HP:0002113)2.37329388
77Arterial thrombosis (HP:0004420)2.34495295
78Abnormality of the nasal mucosa (HP:0000433)2.34415063
79Gastrointestinal stroma tumor (HP:0100723)2.34321715
80Gastrointestinal inflammation (HP:0004386)2.32544166
81Neurofibrillary tangles (HP:0002185)2.31799024
82Pulmonary embolism (HP:0002204)2.31065756
83Gingival bleeding (HP:0000225)2.31019618
84Epistaxis (HP:0000421)2.28342857
85Granulocytopenia (HP:0001913)2.27631237
86Combined immunodeficiency (HP:0005387)2.26514011
87Basal ganglia calcification (HP:0002135)2.25048474
88Disinhibition (HP:0000734)2.24484323
89Agammaglobulinemia (HP:0004432)2.24195909
90Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.22543425
91Gangrene (HP:0100758)2.20940884
92Hemoptysis (HP:0002105)2.20592809
93Colitis (HP:0002583)2.20060396
94Abnormality of the pleura (HP:0002103)2.19779500
95Autoimmune hemolytic anemia (HP:0001890)2.18777023
96Urinary glycosaminoglycan excretion (HP:0003541)2.18362471
97Mucopolysacchariduria (HP:0008155)2.18362471
98Increased IgM level (HP:0003496)2.18234381
99Increased serum ferritin (HP:0003281)2.18189327
100Osteomyelitis (HP:0002754)2.18043102
101Recurrent lower respiratory tract infections (HP:0002783)2.17579514
102Progressive neurologic deterioration (HP:0002344)2.16319806
103Hypertensive crisis (HP:0100735)2.12916053
104Sepsis (HP:0100806)2.11789048
105Microcytic anemia (HP:0001935)2.11518816
106Poor head control (HP:0002421)2.11310186
107Increased IgE level (HP:0003212)2.10321160
108Abnormality of the prostate (HP:0008775)2.10241542
109B lymphocytopenia (HP:0010976)2.10128892
110Abnormality of B cell number (HP:0010975)2.10128892
111Premature loss of primary teeth (HP:0006323)2.05495551
112Skin ulcer (HP:0200042)2.05187263
113Glomerulonephritis (HP:0000099)2.05082441
114IgG deficiency (HP:0004315)2.04358614
115Periodontitis (HP:0000704)2.03443998
116Glomerulopathy (HP:0100820)2.02095073
117Polycythemia (HP:0001901)2.00236342
118Prolonged bleeding time (HP:0003010)1.99829051
119Polyneuropathy (HP:0001271)1.98428324
120Abnormality of polysaccharide metabolism (HP:0011012)1.98117975
121Restrictive lung disease (HP:0002091)1.97729434
122Chronic diarrhea (HP:0002028)1.96802866
123Arthralgia (HP:0002829)1.96508207
124Abnormality of the pericardium (HP:0001697)1.95727478
125Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94090362
126Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94090362
127Skin rash (HP:0000988)1.92641787

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.16820093
2BLK3.30053196
3IRAK42.98853677
4EPHB12.98638448
5TBK12.80924399
6MAP3K142.61863987
7TXK2.55930476
8TYK22.42528755
9KIT2.24331764
10IKBKE2.22712131
11CLK12.20404639
12TESK22.16860261
13BTK2.09200715
14PIM22.01597933
15ZAP701.99548443
16MAP3K31.98172936
17TAOK11.93269691
18TAOK21.92045779
19TEC1.91781051
20STK101.89893580
21IKBKB1.85369170
22CSF1R1.82773324
23ERN11.82700558
24TGFBR21.73752279
25JAK31.72865497
26KDR1.69326288
27ITK1.67977302
28CSK1.67258048
29RIPK41.60861864
30SIK31.60159747
31NME21.58738133
32SYK1.53037712
33IRAK31.48163514
34LCK1.36765181
35HCK1.34278762
36MST41.32040284
37FES1.26223956
38MAPKAPK51.25304408
39LYN1.23119604
40JAK11.20959414
41PBK1.20296999
42LRRK21.17345704
43BMPR21.15869016
44MAP2K31.14893809
45STK391.10260436
46TRPM71.09261214
47FGR1.04177691
48CDK190.99669216
49LIMK10.98804630
50PIM10.93675532
51SMG10.93440126
52GRK60.92405889
53MAP3K130.88510750
54PKN10.87670344
55TRIB30.85519911
56RPS6KA40.84243878
57MAP3K110.84121089
58SIK20.80946082
59TESK10.80198674
60CDC42BPA0.77135012
61KSR20.74493206
62TAOK30.73193277
63PRKD20.72921121
64NLK0.71839001
65PRKCQ0.70966635
66JAK20.70076796
67SIK10.69892921
68EIF2AK30.69289900
69MAP3K100.68518765
70STK40.66831586
71FGFR40.66640872
72IRAK10.65882142
73CHUK0.64950424
74MAPKAPK20.64890360
75OXSR10.63906840
76GRK70.63374635
77PDPK10.62521559
78MATK0.60945144
79MARK20.60073221
80PTK60.59159630
81MAP3K50.58192424
82MAPK120.55867090
83ARAF0.55764544
84BMX0.55732516
85PRKCD0.55642856
86IRAK20.55432323
87RPS6KA50.55118707
88ABL10.49625837
89MOS0.48470475
90ABL20.47350042
91MAPK40.46784253
92EIF2AK20.46242432
93MAP2K60.45791558
94MAP3K80.45524019
95MAP3K60.44265972
96PAK40.44250651
97RPS6KC10.43942828
98RPS6KL10.43942828
99PRKG20.43008652
100FYN0.41262945
101YES10.40919186
102MARK30.40299237
103MAPK70.39346601
104CDK40.39033423
105RPS6KA60.37628226
106MET0.37586461
107ILK0.36239532
108FLT30.35973505
109EGFR0.35442663
110SCYL20.35412133
111PRPF4B0.34589147
112PIK3CG0.34529312
113ROCK20.34208280
114BUB10.34144584
115MAPK110.33898081
116PAK10.33772294
117NEK90.33167712
118ALK0.32435768
119CSNK1G30.32250666
120TNK20.31805183
121RAF10.29194634
122CSNK1A1L0.29027517
123STK160.28618718
124HIPK20.28499936
125DAPK20.28386014
126MAP3K10.27961042
127PTK2B0.27712670
128ADRBK20.27502742
129MAP2K20.27334231
130DAPK30.25145690
131PDK10.24250028
132TNIK0.23400259

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.05772178
2Primary immunodeficiency_Homo sapiens_hsa053402.65096510
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.40796778
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.40545957
5Graft-versus-host disease_Homo sapiens_hsa053322.31279616
6Allograft rejection_Homo sapiens_hsa053302.30616631
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24855843
8Staphylococcus aureus infection_Homo sapiens_hsa051502.21651543
9Osteoclast differentiation_Homo sapiens_hsa043802.19741989
10Asthma_Homo sapiens_hsa053102.14992360
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.07276821
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.03732441
13Malaria_Homo sapiens_hsa051442.03369345
14Measles_Homo sapiens_hsa051621.98369883
15Pertussis_Homo sapiens_hsa051331.95769153
16B cell receptor signaling pathway_Homo sapiens_hsa046621.94348034
17Lysosome_Homo sapiens_hsa041421.91747545
18Other glycan degradation_Homo sapiens_hsa005111.86774602
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84854770
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.82153236
21Hematopoietic cell lineage_Homo sapiens_hsa046401.81317696
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74805934
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.74411972
24Antigen processing and presentation_Homo sapiens_hsa046121.72744218
25Legionellosis_Homo sapiens_hsa051341.69231052
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65450761
27Tuberculosis_Homo sapiens_hsa051521.58648782
28Rheumatoid arthritis_Homo sapiens_hsa053231.43390805
29* Shigellosis_Homo sapiens_hsa051311.42225424
30DNA replication_Homo sapiens_hsa030301.40247242
31Herpes simplex infection_Homo sapiens_hsa051681.39978301
32Autoimmune thyroid disease_Homo sapiens_hsa053201.38742025
33Toxoplasmosis_Homo sapiens_hsa051451.37604475
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.36262275
35Chemokine signaling pathway_Homo sapiens_hsa040621.36248519
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35174752
37T cell receptor signaling pathway_Homo sapiens_hsa046601.35057077
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33898614
39* Salmonella infection_Homo sapiens_hsa051321.31254543
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.30611368
41Ribosome_Homo sapiens_hsa030101.29930973
42TNF signaling pathway_Homo sapiens_hsa046681.29192949
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.28911419
44Apoptosis_Homo sapiens_hsa042101.25121158
45Phagosome_Homo sapiens_hsa041451.22904076
46Influenza A_Homo sapiens_hsa051641.20111957
47Protein export_Homo sapiens_hsa030601.09609264
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09265512
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07138621
50Steroid biosynthesis_Homo sapiens_hsa001001.02755064
51Hepatitis B_Homo sapiens_hsa051610.99857590
52Viral myocarditis_Homo sapiens_hsa054160.96146833
53Proteasome_Homo sapiens_hsa030500.95968648
54Ether lipid metabolism_Homo sapiens_hsa005650.95394706
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94772700
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94100690
57African trypanosomiasis_Homo sapiens_hsa051430.89984716
58Acute myeloid leukemia_Homo sapiens_hsa052210.85699989
59Base excision repair_Homo sapiens_hsa034100.82740034
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82031919
61Platelet activation_Homo sapiens_hsa046110.80234525
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79853781
63Sphingolipid metabolism_Homo sapiens_hsa006000.79549825
64Fatty acid elongation_Homo sapiens_hsa000620.79169199
65* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77385089
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76643478
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76457365
68Hepatitis C_Homo sapiens_hsa051600.74579034
69Type I diabetes mellitus_Homo sapiens_hsa049400.74203610
70Mismatch repair_Homo sapiens_hsa034300.72506353
71Non-small cell lung cancer_Homo sapiens_hsa052230.70626816
72Epstein-Barr virus infection_Homo sapiens_hsa051690.69131749
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.68126585
74Non-homologous end-joining_Homo sapiens_hsa034500.65629778
75Pancreatic cancer_Homo sapiens_hsa052120.63917020
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60494731
77Endocytosis_Homo sapiens_hsa041440.59524525
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59519227
79Prolactin signaling pathway_Homo sapiens_hsa049170.56665485
80Chronic myeloid leukemia_Homo sapiens_hsa052200.54469779
81Pentose phosphate pathway_Homo sapiens_hsa000300.54139288
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.53756644
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53096921
84Viral carcinogenesis_Homo sapiens_hsa052030.52564598
85Homologous recombination_Homo sapiens_hsa034400.51591994
86Bladder cancer_Homo sapiens_hsa052190.49310576
87Arachidonic acid metabolism_Homo sapiens_hsa005900.48271037
88Amoebiasis_Homo sapiens_hsa051460.45338196
89Collecting duct acid secretion_Homo sapiens_hsa049660.42930274
90VEGF signaling pathway_Homo sapiens_hsa043700.42747110
91Prion diseases_Homo sapiens_hsa050200.41438582
92Renal cell carcinoma_Homo sapiens_hsa052110.40328753
93Systemic lupus erythematosus_Homo sapiens_hsa053220.39505893
94Folate biosynthesis_Homo sapiens_hsa007900.38815069
95Histidine metabolism_Homo sapiens_hsa003400.38733200
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37987035
97HIF-1 signaling pathway_Homo sapiens_hsa040660.37811051
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35208513
99HTLV-I infection_Homo sapiens_hsa051660.35132830
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34707223
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.34587444
102Small cell lung cancer_Homo sapiens_hsa052220.34576045
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33343189
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.33211149
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30057425
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29145649
107Notch signaling pathway_Homo sapiens_hsa043300.29134134
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28432480
109Renin-angiotensin system_Homo sapiens_hsa046140.27571308
110Sulfur relay system_Homo sapiens_hsa041220.26987204
111p53 signaling pathway_Homo sapiens_hsa041150.26916386
112FoxO signaling pathway_Homo sapiens_hsa040680.25831869
113MAPK signaling pathway_Homo sapiens_hsa040100.25485827
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25022659
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24507737
116Galactose metabolism_Homo sapiens_hsa000520.24081303
117Insulin resistance_Homo sapiens_hsa049310.22523764
118GnRH signaling pathway_Homo sapiens_hsa049120.21968192
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.21147683
120Complement and coagulation cascades_Homo sapiens_hsa046100.17968217
121Colorectal cancer_Homo sapiens_hsa052100.17584982
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16293416
123Fructose and mannose metabolism_Homo sapiens_hsa000510.15912959
124Endometrial cancer_Homo sapiens_hsa052130.15443055
125Regulation of autophagy_Homo sapiens_hsa041400.15133361
126mTOR signaling pathway_Homo sapiens_hsa041500.14995941

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